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282 results on '"Rankin, Erinn B."'

1. Dosimetric calibration of an anatomically specific ultra-high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments

Author

Wang, Jinghui, Melemenidis, Stavros, Manjappa, Rakesh, Viswanathan, Vignesh, Ashraf, Ramish M., Levy, Karen, Skinner, Lawrie, Soto, Luis A., Chow, Stephanie, Lau, Brianna, Ko, Ryan B., Graves, Edward E., Yu, Amy S., Bush, Karl K., Surucu, Murat, Rankin, Erinn B., Loo Jr, Billy W., Schüler, Emil, and Maxim, Peter G.

Subjects
Physics - Medical Physics
Abstract

We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiology experiments. UHDR electron beams were controlled by a microcontroller and relay interfaced with the respiratory gating system. We produced beam collimators with indexed stereotactic mouse positioning devices to provide anatomically specific preclinical treatments. Treatment delivery was monitored directly with an ionization chamber, and charge measurements were correlated with radiochromic film at the entry surface of the mice. The setup for conventional (CONV) dose rate irradiation was similar but the source-to-surface distance was longer. Monte Carlo simulations and film dosimetry were used to characterize beam properties and dose distributions. The mean electron beam energies before the flattening filter were 18.8 MeV (UHDR) and 17.7 MeV (CONV), with corresponding values at the mouse surface of 17.2 MeV and 16.2 MeV. The charges measured with an external ion chamber were linearly correlated with the mouse entrance dose. Use of relay gating for pulse control initially led to a delivery failure rate of 20% ($+/-$ 1 pulse); adjustments to account for the linac latency improved this rate to <1/20. Beam field sizes for two anatomically specific mouse collimators (4x4 $cm^2$ for whole-abdomen and 1.5x1.5 $cm^2$ for unilateral lung irradiation) were accurate within <5% and had low radiation leakage (<4%). Normalizing the dose at the center of the mouse (~0.75 cm depth) produced UHDR and CONV doses to the irradiated volumes with >95% agreement. We successfully configured a clinical linear accelerator for increased output and developed a robust preclinical platform for anatomically specific irradiation, with highly accurate and precise temporal and spatial dose delivery, for both CONV and UHDR applications., Comment: Jinghui Wang and Stavros Melemenidis are co-first authors, and Emil Sch\"uler and Peter G. Maxim are co-senior/co-corresponding authors

Published
2023

3. The controversial role and therapeutic development of the m6A demethylase FTO in renal cell carcinoma

Author

Zhang, Dalin, Wornow, Sarah, Peehl, Donna M, Rankin, Erinn B, and Brooks, James D

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Kidney Disease, Cancer, 2.1 Biological and endogenous factors, Aetiology, m(6)A RNA demethylase, FTO, Renal cell carcinoma, Cancer progression, Prognosis, Inhibitors, Biochemistry and Cell Biology, Clinical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Fat mass and obesity-associated (FTO) protein, the first m6A demethylase identified in 2011, regulates multiple aspects of RNA biology including splicing, localization, stability, and translation. Accumulating data show that FTO is involved in numerous physiological processes and is implicated in multiple cancers including renal cell carcinoma (RCC). However, the exact role of FTO in RCC remains controversial. Some studies demonstrated that decreased FTO expression was associated with aggressive clinical features and shorter overall survival in clear cell RCC (ccRCC) patients, while others found that FTO inhibition selectively reduced the growth and survival of VHL-deficient ccRCC cells in vitro and in vivo. Here, we review the evidence supporting either a promoting or suppressive role of FTO in kidney cancers, the mechanisms of action of FTO, and recent progress in developing FTO inhibitors.

Published
2022

5. Evaluating the Reproducibility of Mouse Anatomy under Rotation in a Custom Immobilization Device for Conformal FLASH Radiotherapy

Author

Ko, Ryan B, Soto, Luis A, von Eyben, Rie, Melemenidis, Stavros, Rankin, Erinn B, Maxim, Peter G, Graves, Edward E, and Loo, Billy W

Subjects
Cancer, Bioengineering, Animals, Mice, Mice, Inbred C57BL, Mice, Nude, Phantoms, Imaging, Radiotherapy, Conformal, Reproducibility of Results, Rotation, X-Ray Microtomography, Physical Sciences, Biological Sciences, Medical and Health Sciences, Oncology & Carcinogenesis
Abstract

The observation of an enhanced therapeutic index for FLASH radiotherapy in mice has created interest in practical laboratory-based FLASH irradiators. To date, systems capable of 3D conformal FLASH irradiation in mice have been lacking. We are developing such a system, incorporating a high-current linear accelerator to produce a collimated X-ray beam in a stationary beamline design, rotating the mouse about a longitudinal axis to achieve conformal irradiation from multiple beam directions. The purpose of this work was to evaluate the reproducibility of mouse anatomy under rotation at speeds compatible with conformal FLASH delivery. Three short-hair mice and two hairless mice were immobilized under anesthesia in body weight-specific contoured plastic molds, and subjected to three rotational (up to 3 revolutions/s) and two non-rotational movement interventions. MicroCT images were acquired before and after each intervention. The displacements of 11 anatomic landmarks were measured on the image pairs. The displacement of the anatomical landmarks with any of the interventions was 0.5 mm or less for 92.4% of measurements, with a single measurement out of 275 (11 landmarks × 5 interventions × 5 mice) reaching 1 mm. There was no significant difference in the displacements associated with rotation compared to those associated with moving the immobilized mouse in and out of a scanner or with leaving the mouse in place for 5 min with no motion. There were no significant differences in displacements between mice with or without hair, although the analysis is limited by small numbers, or between different anatomic landmarks. These results show that anatomic reproducibility under rotation speed corresponding to FLASH irradiation times appears to be compatible with conformal/stereotactic irradiation in mice.

Published
2020

6. Navigating the Critical Translational Questions for Implementing FLASH in the Clinic.

Author

Loo, Billy W., Verginadis, Ioannis I., Sørensen, Brita Singers, Mascia, Anthony E., Perentesis, John P., Koong, Albert C., Schüler, Emil, Rankin, Erinn B., Maxim, Peter G., Limoli, Charles L., and Vozenin, Marie-Catherine

Abstract

The "FLASH effect" is an increased therapeutic index, that is, reduced normal tissue toxicity for a given degree of anti-cancer efficacy, produced by ultra-rapid irradiation delivered on time scales orders of magnitude shorter than currently conventional in the clinic for the same doses. This phenomenon has been observed in numerous preclinical in vivo tumor and normal tissue models. While the underlying biological mechanism(s) remain to be elucidated, a path to clinical implementation of FLASH can be paved by addressing several critical translational questions. Technological questions pertinent to each beam type (eg , electron, proton, photon) also dictate the logical progression of experimentation required to move forward in safe and decisive clinical trials. Here we review the available preclinical data pertaining to these questions and how they may inform strategies for FLASH cancer therapy clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Supplementary Data from Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer

Author

Miao, Yu Rebecca, primary, Thakkar, Kaushik N., primary, Qian, Jin, primary, Kariolis, Mihalis S., primary, Huang, Wei, primary, Nandagopal, Saravanan, primary, Yang, Teddy Tat Chi, primary, Diep, Anh N., primary, Cherf, Gerald Maxwell, primary, Xu, Yu, primary, Moon, Eui Jung, primary, Xiao, Yiren, primary, Alemany, Haizea, primary, Li, Tiane, primary, Yu, Wenhua, primary, Wei, Bo, primary, Rankin, Erinn B., primary, and Giaccia, Amato J., primary

Published
2024
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8. Data from Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer

Author

Miao, Yu Rebecca, primary, Thakkar, Kaushik N., primary, Qian, Jin, primary, Kariolis, Mihalis S., primary, Huang, Wei, primary, Nandagopal, Saravanan, primary, Yang, Teddy Tat Chi, primary, Diep, Anh N., primary, Cherf, Gerald Maxwell, primary, Xu, Yu, primary, Moon, Eui Jung, primary, Xiao, Yiren, primary, Alemany, Haizea, primary, Li, Tiane, primary, Yu, Wenhua, primary, Wei, Bo, primary, Rankin, Erinn B., primary, and Giaccia, Amato J., primary

Published
2024
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10. Reprogramming the immunological microenvironment through radiation and targeting Axl.

Author

Aguilera, Todd A, Rafat, Marjan, Castellini, Laura, Shehade, Hussein, Kariolis, Mihalis S, Hui, Angela Bik-Yu, Stehr, Henning, von Eyben, Rie, Jiang, Dadi, Ellies, Lesley G, Koong, Albert C, Diehn, Maximilian, Rankin, Erinn B, Graves, Edward E, and Giaccia, Amato J

Subjects
Cell Line, Tumor, Animals, Mice, Inbred C57BL, Mice, Transgenic, Neoplasms, Receptor Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Histocompatibility Antigens Class I, Cytokines, Immunotherapy, Immunosuppression, Combined Modality Therapy, Cell Proliferation, Immunity, Radiation Tolerance, Models, Biological, Molecular Targeted Therapy, Tumor Microenvironment, Cell Line, Tumor, Mice, Inbred C57BL, Transgenic, Models, Biological, Immunization, Vaccine Related, Cancer, Breast Cancer
Abstract

Increasing evidence suggests that ionizing radiation therapy (RT) in combination with checkpoint immunotherapy is highly effective in treating a subset of cancers. To better understand the limited responses to this combination we analysed the genetic, microenvironmental, and immune factors in tumours derived from a transgenic breast cancer model. We identified two tumours with similar growth characteristics but different RT responses primarily due to an antitumour immune response. The combination of RT and checkpoint immunotherapy resulted in cures in the responsive but not the unresponsive tumours. Profiling the tumours revealed that the Axl receptor tyrosine kinase is overexpressed in the unresponsive tumours, and Axl knockout resulted in slower growth and increased radiosensitivity. These changes were associated with a CD8+ T-cell response, which was improved in combination with checkpoint immunotherapy. These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.

Published
2016

15. Contributors

Author

Abbruzzese, James L., primary, Abdel-Wahab, Omar, additional, Abou-Alfa, Ghassan K., additional, Abrahm, Janet L., additional, Abrams, Jeffrey S., additional, Abramson, Jeremy S., additional, Aisner, Dara L., additional, Alonso-Basanta, Michelle, additional, Anampa, Jesus, additional, Anderson, Megan E., additional, Antonarakis, Emmanuel S., additional, Aplenc, Richard, additional, Appelbaum, Frederick R., additional, Araujo, Luiz H., additional, Asban, Ammar, additional, Ashwood, Edward, additional, Awan, Farrukh T., additional, Aylward, Juliet L., additional, Balar, Arjun V., additional, Balentine, Courtney J., additional, Barta, Stefan K., additional, Bartlett, Nancy, additional, Basen-Engquist, Karen, additional, Beaupin, Lynda Kwon, additional, Berkowitz, Ross S., additional, Berry, Donald A., additional, Bevers, Therese, additional, Boggess, John F., additional, Brahmer, Julie R., additional, Brown, Janet, additional, Brown, Karen, additional, Brown, Powel, additional, Browner, Ilene, additional, Bunn, Paul A., additional, Burns, William R., additional, Byrd, John C., additional, Cadoo, Karen, additional, Carbone, David P., additional, Carter, H. Ballentine, additional, Castillo, Jorge J., additional, Chang, Alfred E., additional, Chang, Eric, additional, Chanock, Stephen J., additional, Chapuy, Claudia I., additional, Chauhan, Vikash P., additional, Chen, Herbert, additional, Chen, Ronald C., additional, Cheung, Nai-Kong V., additional, Choe, Jennifer H., additional, Christian, Michaele C., additional, Cinciripini, Paul M., additional, Clarke, Michael F., additional, Coleman, Robert E., additional, Coleman, Robert L., additional, Coletta, Adriana M., additional, Collins, Jerry M., additional, Connors, Jean M., additional, Cools, Michael, additional, Coombes, Kevin R., additional, Cortes, Jorge, additional, Costa, Mauro W., additional, Covey, Anne, additional, Cowan, Kenneth H., additional, Crane, Christopher H., additional, Crawford, Jeffrey, additional, Crooks, Kristy, additional, Culkin, Daniel J., additional, Czito, Brian G., additional, Dalerba, Piero, additional, Dalmau, Josep, additional, Dang, Mai, additional, D'Angelica, Michael, additional, Davies, Kurtis D., additional, Davis, Myrtle, additional, Dea, Nicolas, additional, De Jesus-Acosta, Ana, additional, DeMarzo, Angelo M., additional, DeWeese, Theodore L., additional, Diehn, Maximilian, additional, Digumarthy, Subba R., additional, Dispenzieri, Angela, additional, Do, Khanh T., additional, Dobrenkov, Konstantin, additional, Dome, Jeffrey S., additional, Doroshow, James H., additional, Dorsey, Jay F., additional, Dubard-Gault, Marianne, additional, DuBois, Steven G., additional, Duda, Dan G., additional, Dunlop, Malcolm, additional, Duska, Linda R., additional, Duvic, Madeleine, additional, El Dika, Imane, additional, El-Serag, Hashem, additional, Engelmann, Jeffrey M., additional, Ettinger, David S., additional, Fashoyin-Aje, Lola A., additional, Fearon, Eric R., additional, Ford, James M., additional, Franklin, Wilbur A., additional, Freer, Phoebe E., additional, Freidlin, Boris, additional, Freifeld, Alison G., additional, Friedlander, Terence W., additional, Friedman, Debra L., additional, Fuller, Arian F., additional, Galluzzi, Lorenzo, additional, Gebhardt, Mark C., additional, George, Daniel J., additional, Geyer, Mark B., additional, Giaccia, Amato J., additional, Gilbert, Mark R., additional, Goldner, Whitney, additional, Goldstein, Donald P., additional, Goodman, Annekathryn, additional, Goodman, Karyn A., additional, Gordon, Kathleen, additional, Graeff-Armas, Laura, additional, Greenstein, Alexander J., additional, Grossman, Stuart A., additional, Grupp, Stephan, additional, Gupta, Arjun, additional, Haider, Irfanullah, additional, Haigentz, Missak, additional, Hainsworth, John D., additional, Haithcock, Benjamin E., additional, Hallemeier, Christopher L., additional, Hanash, Samir, additional, Hanrahan, Aphrothiti J., additional, Harding, James, additional, Harrison, Michael R., additional, Hasham, Muneer G., additional, Hawk, Ernest, additional, Hayman, Jonathan, additional, Heinlen, Jonathan E., additional, Henry, N. Lynn, additional, Herman, Joseph, additional, Hobbs, Brian P., additional, Holen, Ingunn, additional, Horn, Leora, additional, Horowitz, Neil S., additional, Horwitz, Steven M., additional, Houghton, Odette, additional, Howard, Scott C., additional, Hudis, Clifford A., additional, Hunger, Stephen P., additional, Hurria, Arti, additional, Ilson, David H., additional, Im, Annie, additional, Iyer, Gopa, additional, Jaffee, Elizabeth M., additional, Jagsi, Reshma, additional, Jain, Rakesh K., additional, Jarnagin, William, additional, Jatoi, Aminah, additional, Jhingran, Anuja, additional, Johnson, David H., additional, Johnston, Brian, additional, Johnston, Patrick G., additional, Judy, Kevin D., additional, Kachnic, Lisa A., additional, Kaidar-Person, Orit, additional, Kalva, Sanjeeva, additional, Kamin, Deborah Y., additional, Kantarjian, Hagop, additional, Karakousis, Giorgos, additional, Karam-Hage, Maher, additional, Kaskas, Nadine M., additional, Kastan, Michael B., additional, Katabi, Nora, additional, Kaul, Daniel R., additional, Kelley, Scott R., additional, Kemeny, Nancy, additional, Kent, Erin E., additional, Kepp, Oliver, additional, Khagi, Simon, additional, Kilgore, Joshua E., additional, Kim, D. Nathan, additional, Kleinschmidt-DeMasters, Bette K., additional, Korn, Edward L., additional, Kroemer, Guido, additional, Ku, Geoffrey Y., additional, Kummar, Shivaani, additional, Ky, Bonnie, additional, Laheru, Daniel A., additional, Lambert, Paul F., additional, Lawler, Mark, additional, Le-Rademacher, Jennifer G., additional, Lee, John Y.K., additional, Lee, Nancy Y., additional, Lee, Susanna L., additional, Leeman, Jonathan E., additional, Linkermann, Andreas, additional, Liu, Jinsong, additional, Lo, Simon, additional, Locasale, Jason W., additional, Loprinzi, Charles L., additional, Lowery, Maeve, additional, Ludwig, Emmy, additional, Lunning, Matthew A., additional, Lustig, Robert A., additional, Machtay, Mitchell, additional, Mackall, Crystal, additional, Mahvi, David A., additional, Mahvi, David M., additional, Maity, Amit, additional, Majithia, Neil, additional, Malumbres, Marcos, additional, Maresso, Karen Colbert, additional, Martin, John D., additional, Matsuo, Koji, additional, Matthews, Natalie H., additional, Mauro, Lauren, additional, Mayer, R. Samuel, additional, McCaskill-Stevens, Worta, additional, McNamara, Megan A., additional, Mehta-Shah, Neha, additional, Merritt, Robert E., additional, Milowsky, Matthew I., additional, Minasian, Lori M., additional, Mitchell, Tara C., additional, Mitsis, Demytra, additional, Mollica, Michelle, additional, Mooney, Margaret, additional, Moustafa, Farah, additional, Nabati, Lida, additional, Naidoo, Jarushka, additional, Narang, Amol, additional, Nelson, Heidi, additional, Nelson, William G., additional, Nesbit, Suzanne, additional, Niglas, Mark, additional, O'Connor, Tracey, additional, Offit, Kenneth, additional, Onciu, Mihaela, additional, O’Reilly, Eileen M., additional, Ostrander, Elaine A., additional, Pappas-Taffer, Lisa, additional, Pardoll, Drew, additional, Park, Jae H., additional, Patel, Anery, additional, Patel, Anish J., additional, Patierno, Steven R., additional, Pavletic, Steven Z., additional, Phillips, Peter C., additional, Post, Miriam D., additional, Pruitt, Amy A., additional, Querfeld, Christiane, additional, Rabius, Vance A., additional, Rajkumar, S. Vincent, additional, Ramadan, Mohammad O., additional, Rankin, Erinn B., additional, Reddy, Sushanth, additional, Reid, Michael A., additional, Reznik, Scott, additional, Rizack, Tina, additional, Robinson, Jason D., additional, Robinson-Bostom, Leslie, additional, Rodriguez-Galindo, Carlos, additional, Romesser, Paul B., additional, Rosen, Steven T., additional, Rosenfeld, Myrna R., additional, Rosenthal, Nadia, additional, Ross, Meredith, additional, Rowland, Julia H., additional, Russell, Anthony H., additional, Sabel, Michael S., additional, Sahgal, Arjun, additional, Salinas, Ryan D., additional, Salo-Mullen, Erin E., additional, Salto-Tellez, Manuel, additional, Sanderson, Sydney M., additional, Sandlund, John T., additional, Santana, Victor M., additional, Savage, Michelle, additional, Schreiber, Eric C., additional, Schuchter, Lynn, additional, Schultz, Liora, additional, Seiden, Michael V., additional, Sellers, Morgan M., additional, Shah, Payal D., additional, Shia, Jinru, additional, Shilo, Konstantin, additional, Small, Eric, additional, Smith, Angela B., additional, Snow, Stephen N., additional, Solit, David B., additional, Sood, Anil K., additional, Soto-Perez-de-Celis, Enrique, additional, Sparano, Joseph A., additional, Spiegelman, Vladimir S., additional, Spunt, Sheri L., additional, Stadler, Zsofia K., additional, Steensma, David P., additional, Stone, Richard M., additional, Stranne, Steven Kent, additional, Stratton, Kelly, additional, Sugden, Bill, additional, Swanson, Andrew M., additional, Tallman, Martin S., additional, Talmadge, James E., additional, Teachey, David T., additional, Teba, Catalina V., additional, Tefferi, Ayalew, additional, Teh, Bin Tean, additional, Teng, Joyce M.C., additional, Tepper, Joel E., additional, Thaker, Premal H., additional, Thrift, Aaron P., additional, Tran, Arthur-Quan, additional, Triska, Grace, additional, Trump, Donald, additional, Tsai, Kenneth, additional, Tseng, Chia-Lin, additional, Tseng, Diane, additional, Van Schaeybroeck, Sandra, additional, Van Tine, Brian A., additional, Vanness, Erin R., additional, Varadhachary, Gauri, additional, Varella-Garcia, Marileila, additional, Wahl, Richard L., additional, Walsh, Michael F., additional, Wang, Thomas, additional, Weiss, Jared, additional, Weissman, Irving L., additional, Westin, Shannon N., additional, White, Jeffrey D., additional, Wilson, Richard, additional, Wong, Richard J., additional, Wood, Gary S., additional, Xu, Yaohui G., additional, Xu-Welliver, Meng, additional, Yust-Katz, Shlomit, additional, Zagar, Timothy, additional, Zeman, Elaine M., additional, Zhang, Tian, additional, and Zwiebel, James A., additional

Published
2020
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17. Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice

Author

Levy, Karen, Natarajan, Suchitra, Wang, Jinghui, Chow, Stephanie, Eggold, Joshua T, Loo, Phoebe E, Manjappa, Rakesh, Melemenidis, Stavros, Lartey, Frederick M, Schüler, Emil, Skinner, Lawrie, Rafat, Marjan, Ko, Ryan, Kim, Anna, H. Al-Rawi, Duaa, von Eyben, Rie, Dorigo, Oliver, Casey, Kerriann M, Graves, Edward E, Bush, Karl, Yu, Amy S, Koong, Albert C, Maxim, Peter G, Loo, Billy W, and Rankin, Erinn B

Subjects
Digestive Diseases, Vaccine Related, Prevention, Rare Diseases, Biodefense, Ovarian Cancer, Orphan Drug, Cancer, Animals, Female, Gastrointestinal Tract, Mice, Mice, Inbred C57BL, Ovarian Neoplasms, Radiation Injuries, Experimental, Radiotherapy, Regenerative Medicine, Stem Cell Research, Genetics, Stem Cell Research - Nonembryonic - Non-Human, Adult Stem Cells, Apoptosis, Bone Marrow, Cell Cycle Checkpoints, DNA Breaks, Double-Stranded, DNA Repair, Jejunum, Mice, Transgenic, Radiation Tolerance
Abstract

Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes. In particular, the highly radiosensitive intestine limits the use of radiation for patients with intra-abdominal tumors. In metastatic ovarian cancer, total abdominal irradiation (TAI) was used as an effective postsurgical adjuvant therapy in the management of abdominal metastases. However, TAI fell out of favor due to high toxicity of the intestine. Here we utilized an innovative preclinical irradiation platform to compare the safety and efficacy of TAI ultra-high dose rate FLASH irradiation to conventional dose rate (CONV) irradiation in mice. We demonstrate that single high dose TAI-FLASH produced less mortality from gastrointestinal syndrome, spared gut function and epithelial integrity, and spared cell death in crypt base columnar cells compared to TAI-CONV irradiation. Importantly, TAI-FLASH and TAI-CONV irradiation had similar efficacy in reducing tumor burden while improving intestinal function in a preclinical model of ovarian cancer metastasis. These findings suggest that FLASH irradiation may be an effective strategy to enhance the therapeutic index of abdominal radiotherapy, with potential application to metastatic ovarian cancer.

Published
2012

19. Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice

Author

Levy, Karen, Natarajan, Suchitra, Wang, Jinghui, Chow, Stephanie, Eggold, Joshua T., Loo, Phoebe E., Manjappa, Rakesh, Melemenidis, Stavros, Lartey, Frederick M., Schüler, Emil, Skinner, Lawrie, Rafat, Marjan, Ko, Ryan, Kim, Anna, H. Al-Rawi, Duaa, von Eyben, Rie, Dorigo, Oliver, Casey, Kerriann M., Graves, Edward E., Bush, Karl, Yu, Amy S., Koong, Albert C., Maxim, Peter G., Loo, Jr., Billy W., and Rankin, Erinn B.

Published
2020
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20. Data from Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

Author

Li, Albert M., primary, Ducker, Gregory S., primary, Li, Yang, primary, Seoane, Jose A., primary, Xiao, Yiren, primary, Melemenidis, Stavros, primary, Zhou, Yiren, primary, Liu, Ling, primary, Vanharanta, Sakari, primary, Graves, Edward E., primary, Rankin, Erinn B., primary, Curtis, Christina, primary, Massagué, Joan, primary, Rabinowitz, Joshua D., primary, Thompson, Craig B., primary, and Ye, Jiangbin, primary

Published
2023
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21. Supplementary Data from GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress

Author

Mullen, Mary M., primary, Lomonosova, Elena, primary, Toboni, Michael D., primary, Oplt, Alyssa, primary, Cybulla, Emily, primary, Blachut, Barbara, primary, Zhao, Peinan, primary, Noia, Hollie, primary, Wilke, Daniel, primary, Rankin, Erinn B., primary, Kuroki, Lindsay M., primary, Hagemann, Andrea R., primary, Hagemann, Ian S., primary, McCourt, Carolyn K., primary, Thaker, Premal H., primary, Mutch, David G., primary, Powell, Matthew A., primary, Mosammaparast, Nima, primary, Vindigni, Alessandro, primary, and Fuh, Katherine C., primary

Published
2023
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22. Data from GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress

Author

Mullen, Mary M., primary, Lomonosova, Elena, primary, Toboni, Michael D., primary, Oplt, Alyssa, primary, Cybulla, Emily, primary, Blachut, Barbara, primary, Zhao, Peinan, primary, Noia, Hollie, primary, Wilke, Daniel, primary, Rankin, Erinn B., primary, Kuroki, Lindsay M., primary, Hagemann, Andrea R., primary, Hagemann, Ian S., primary, McCourt, Carolyn K., primary, Thaker, Premal H., primary, Mutch, David G., primary, Powell, Matthew A., primary, Mosammaparast, Nima, primary, Vindigni, Alessandro, primary, and Fuh, Katherine C., primary

Published
2023
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23. Supplementary Data from Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

Author

Li, Albert M., primary, Ducker, Gregory S., primary, Li, Yang, primary, Seoane, Jose A., primary, Xiao, Yiren, primary, Melemenidis, Stavros, primary, Zhou, Yiren, primary, Liu, Ling, primary, Vanharanta, Sakari, primary, Graves, Edward E., primary, Rankin, Erinn B., primary, Curtis, Christina, primary, Massagué, Joan, primary, Rabinowitz, Joshua D., primary, Thompson, Craig B., primary, and Ye, Jiangbin, primary

Published
2023
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24. Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling

Author

Qian, Jin, LeSavage, Bauer L., Hubka, Kelsea M., Ma, Chenkai, Natarajan, Suchitra, Eggold, Joshua T., Xiao, Yiren, Fuh, Katherine C., Krishnan, Venkatesh, Enejder, Annika, Heilshorn, Sarah C., Dorigo, Oliver, and Rankin, Erinn B.

Subjects
Oncology, Experimental, Glycoproteins -- Health aspects -- Genetic aspects, Drug resistance -- Research, Mesothelium -- Health aspects -- Genetic aspects, Cellular signal transduction -- Research, Epithelial cells -- Health aspects -- Genetic aspects, Cancer -- Research, Ovarian cancer -- Genetic aspects -- Development and progression -- Drug therapy, Health care industry
Abstract

Ovarian cancer is the leading cause of gynecological malignancy-related deaths, due to its widespread intraperitoneal metastases and acquired chemoresistance. Mesothelial cells are an important cellular component of the ovarian cancer microenvironment that promote metastasis. However, their role in chemoresistance is unclear. Here, we investigated whether cancer-associated mesothelial cells promote ovarian cancer chemoresistance and stemness in vitro and in vivo. We found that osteopontin is a key secreted factor that drives mesothelial-mediated ovarian cancer chemoresistance and stemness. Osteopontin is a secreted glycoprotein that is clinically associated with poor prognosis and chemoresistance in ovarian cancer. Mechanistically, ovarian cancer cells induced osteopontin expression and secretion by mesothelial cells through TGF-[beta] signaling. Osteopontin facilitated ovarian cancer cell chemoresistance via the activation of the CD44 receptor, PI3K/AKT signaling, and ABC drug efflux transporter activity. Importantly, therapeutic inhibition of osteopontin markedly improved the efficacy of cisplatin in both human and mouse ovarian tumor xenografts. Collectively, our results highlight mesothelial cells as a key driver of ovarian cancer chemoresistance and suggest that therapeutic targeting of osteopontin may be an effective strategy for enhancing platinum sensitivity in ovarian cancer., Introduction Epithelial ovarian cancer is the leading cause of gynecological malignancy-related deaths (1). High-grade serous ovarian cancer (HGSOC) is the most prevalent form, which accounts for 70% to 80% of [...]

Published
2021
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25. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models

Author

Mehibel, Manal, Xu, Yu, Li, Caiyun G., Moon, Eui Jung, Thakkar, Kaushik N., Diep, Anh N., Kim, Ryan K., Bloomstein, Joshua D., Xiao, Yiren, Bacal, Julien, Saldivar, Joshua C., Le, Quynh-Thu, Cimprich, Karlene A., Rankin, Erinn B., and Giaccia, Amato J.

Subjects
Drug resistance -- Physiological aspects, Cancer -- Care and treatment, Hypoxia -- Physiological aspects, Cancer cells -- Physiological aspects, Breast cancer -- Physiological aspects -- Models -- Drug therapy, Health care industry
Abstract

Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through suppression of HR. While this synergistic killing occurs under severe hypoxia (, Introduction Cytotoxic therapies have long been the backbone of cancer therapy, as they represent an effective means of killing large numbers of tumor cells. A common problem with cytotoxic therapies [...]

Published
2021
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26. Supplementary Methods from Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis

Author

Natarajan, Suchitra, primary, Foreman, Kaitlyn M., primary, Soriano, Michaela I., primary, Rossen, Ninna S., primary, Shehade, Hussein, primary, Fregoso, Daniel R., primary, Eggold, Joshua T., primary, Krishnan, Venkatesh, primary, Dorigo, Oliver, primary, Krieg, Adam J., primary, Heilshorn, Sarah C., primary, Sinha, Subarna, primary, Fuh, Katherine C., primary, and Rankin, Erinn B., primary

Published
2023
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27. Supplementary Figures and Legends from Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis

Author

Natarajan, Suchitra, primary, Foreman, Kaitlyn M., primary, Soriano, Michaela I., primary, Rossen, Ninna S., primary, Shehade, Hussein, primary, Fregoso, Daniel R., primary, Eggold, Joshua T., primary, Krishnan, Venkatesh, primary, Dorigo, Oliver, primary, Krieg, Adam J., primary, Heilshorn, Sarah C., primary, Sinha, Subarna, primary, Fuh, Katherine C., primary, and Rankin, Erinn B., primary

Published
2023
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28. Supplemental Table 2 from Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Author

Jiang, Haowen, primary, Greathouse, Rachel L., primary, Tiche, Sarah Jane, primary, Zhao, Man, primary, He, Bo, primary, Li, Yang, primary, Li, Albert M., primary, Forgo, Balint, primary, Yip, Michaela, primary, Li, Allison, primary, Shih, Moriah, primary, Banuelos, Selene, primary, Zhou, Meng-Ning, primary, Gruber, Joshua J., primary, Rankin, Erinn B., primary, Hu, Zhen, primary, Shimada, Hiroyuki, primary, Chiu, Bill, primary, and Ye, Jiangbin, primary

Published
2023
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29. Supplementary Table S1 from Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis

Author

Natarajan, Suchitra, primary, Foreman, Kaitlyn M., primary, Soriano, Michaela I., primary, Rossen, Ninna S., primary, Shehade, Hussein, primary, Fregoso, Daniel R., primary, Eggold, Joshua T., primary, Krishnan, Venkatesh, primary, Dorigo, Oliver, primary, Krieg, Adam J., primary, Heilshorn, Sarah C., primary, Sinha, Subarna, primary, Fuh, Katherine C., primary, and Rankin, Erinn B., primary

Published
2023
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30. Supplementary Data from Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Author

Jiang, Haowen, primary, Greathouse, Rachel L., primary, Tiche, Sarah Jane, primary, Zhao, Man, primary, He, Bo, primary, Li, Yang, primary, Li, Albert M., primary, Forgo, Balint, primary, Yip, Michaela, primary, Li, Allison, primary, Shih, Moriah, primary, Banuelos, Selene, primary, Zhou, Meng-Ning, primary, Gruber, Joshua J., primary, Rankin, Erinn B., primary, Hu, Zhen, primary, Shimada, Hiroyuki, primary, Chiu, Bill, primary, and Ye, Jiangbin, primary

Published
2023
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31. Data from Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis

Author

Natarajan, Suchitra, primary, Foreman, Kaitlyn M., primary, Soriano, Michaela I., primary, Rossen, Ninna S., primary, Shehade, Hussein, primary, Fregoso, Daniel R., primary, Eggold, Joshua T., primary, Krishnan, Venkatesh, primary, Dorigo, Oliver, primary, Krieg, Adam J., primary, Heilshorn, Sarah C., primary, Sinha, Subarna, primary, Fuh, Katherine C., primary, and Rankin, Erinn B., primary

Published
2023
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32. Supplemental Table 4 from Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Author

Jiang, Haowen, primary, Greathouse, Rachel L., primary, Tiche, Sarah Jane, primary, Zhao, Man, primary, He, Bo, primary, Li, Yang, primary, Li, Albert M., primary, Forgo, Balint, primary, Yip, Michaela, primary, Li, Allison, primary, Shih, Moriah, primary, Banuelos, Selene, primary, Zhou, Meng-Ning, primary, Gruber, Joshua J., primary, Rankin, Erinn B., primary, Hu, Zhen, primary, Shimada, Hiroyuki, primary, Chiu, Bill, primary, and Ye, Jiangbin, primary

Published
2023
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33. Data from S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma

Author

Xiao, Yiren, primary, Zhao, Hongjuan, primary, Tian, Lei, primary, Nolley, Rosalie, primary, Diep, Anh N., primary, Ernst, Anne, primary, Fuh, Katherine C., primary, Miao, Yu Rebecca, primary, von Eyben, Rie, primary, Leppert, John T., primary, Brooks, James D., primary, Peehl, Donna M., primary, Giaccia, Amato J., primary, and Rankin, Erinn B., primary

Published
2023
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34. Supplemental Table 3 from Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Author

Jiang, Haowen, primary, Greathouse, Rachel L., primary, Tiche, Sarah Jane, primary, Zhao, Man, primary, He, Bo, primary, Li, Yang, primary, Li, Albert M., primary, Forgo, Balint, primary, Yip, Michaela, primary, Li, Allison, primary, Shih, Moriah, primary, Banuelos, Selene, primary, Zhou, Meng-Ning, primary, Gruber, Joshua J., primary, Rankin, Erinn B., primary, Hu, Zhen, primary, Shimada, Hiroyuki, primary, Chiu, Bill, primary, and Ye, Jiangbin, primary

Published
2023
Full Text
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35. Supplemental Table 1 from Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Author

Jiang, Haowen, primary, Greathouse, Rachel L., primary, Tiche, Sarah Jane, primary, Zhao, Man, primary, He, Bo, primary, Li, Yang, primary, Li, Albert M., primary, Forgo, Balint, primary, Yip, Michaela, primary, Li, Allison, primary, Shih, Moriah, primary, Banuelos, Selene, primary, Zhou, Meng-Ning, primary, Gruber, Joshua J., primary, Rankin, Erinn B., primary, Hu, Zhen, primary, Shimada, Hiroyuki, primary, Chiu, Bill, primary, and Ye, Jiangbin, primary

Published
2023
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36. Figure S5 from S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma

Author

Xiao, Yiren, primary, Zhao, Hongjuan, primary, Tian, Lei, primary, Nolley, Rosalie, primary, Diep, Anh N., primary, Ernst, Anne, primary, Fuh, Katherine C., primary, Miao, Yu Rebecca, primary, von Eyben, Rie, primary, Leppert, John T., primary, Brooks, James D., primary, Peehl, Donna M., primary, Giaccia, Amato J., primary, and Rankin, Erinn B., primary

Published
2023
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37. Supplementary Data from Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations

Author

Aguilera, Todd A., primary, Elghonaimy, Eslam A., primary, Shehade, Hussein, primary, Rafat, Marjan, primary, Castellini, Laura, primary, Jiang, Dadi, primary, Kariolis, Mihalis, primary, Koong, Albert C., primary, Le, Quynh-Thu, primary, Ellies, Lesley G., primary, Rankin, Erinn B., primary, Graves, Edward E., primary, and Giaccia, Amato J., primary

Published
2023
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38. Table from Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations

Author

Aguilera, Todd A., primary, Elghonaimy, Eslam A., primary, Shehade, Hussein, primary, Rafat, Marjan, primary, Castellini, Laura, primary, Jiang, Dadi, primary, Kariolis, Mihalis, primary, Koong, Albert C., primary, Le, Quynh-Thu, primary, Ellies, Lesley G., primary, Rankin, Erinn B., primary, Graves, Edward E., primary, and Giaccia, Amato J., primary

Published
2023
Full Text
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39. Supplementary Tables from S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma

Author

Xiao, Yiren, primary, Zhao, Hongjuan, primary, Tian, Lei, primary, Nolley, Rosalie, primary, Diep, Anh N., primary, Ernst, Anne, primary, Fuh, Katherine C., primary, Miao, Yu Rebecca, primary, von Eyben, Rie, primary, Leppert, John T., primary, Brooks, James D., primary, Peehl, Donna M., primary, Giaccia, Amato J., primary, and Rankin, Erinn B., primary

Published
2023
Full Text
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