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190 results on '"Rao, Geeta"'

5. Abstract C083: SMNDC1 alters the splicing of ERK to potentiate its activity in pancreatic cancer

Author

Siraj, Md Afjalus, primary, Zhang, Yushan, additional, Chakraborty, Prabir, additional, Tseng, Robert, additional, Ku, Li-Ting, additional, Goda, Grant, additional, Giri, Gilbert, additional, Yugawa, Deanne, additional, Wang, Mathew, additional, Das, Shamik, additional, Dey, Anindya, additional, Dwivedi, Shailendra Dhar, additional, Rao, Geeta, additional, Zhang, Min, additional, Yang, Da, additional, Hossen, Md Nazir, additional, Ding, Wei-Qun, additional, Fung, Kar-Ming, additional, Dominguez, Daniel, additional, Bhattacharya, Resham, additional, Escobar-Hoyos, Luisa, additional, and Mukherjee, Priyabrata, additional

Published
2024
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8. Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation

Author

Elechalawar, Chandra Kumar, primary, Rao, Geeta, additional, Gulla, Suresh Kumar, additional, Patel, Maulin Mukeshchandra, additional, Frickenstein, Alex, additional, Means, Nicolas, additional, Roy, Ram Vinod, additional, Tsiokas, Leonidas, additional, Asfa, Sima, additional, Panja, Prasanta, additional, Rao, Chinthalapally, additional, Wilhelm, Stefan, additional, Bhattacharya, Resham, additional, and Mukherjee, Priyabrata, additional

Published
2023
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12. Gold Nanoparticles Disrupt the IGFBP2/mTOR/PTEN Axis to Inhibit Ovarian Cancer Growth

Author

Hossen, Md. Nazir, primary, Wang, Lin, additional, Dwivedi, Shailendra Kumar Dhar, additional, Zhang, Yushan, additional, Rao, Geeta, additional, Elechalwar, Chandra Kumar, additional, Sheth, Vinit, additional, Dey, Anindya, additional, Asfa, Sima, additional, Gulla, Suresh Kumar, additional, Xu, Chao, additional, Fung, Kar‐Ming, additional, Robertson, J. David, additional, Bieniasz, Magdalena, additional, Wilhelm, Stefan, additional, Bhattacharya, Resham, additional, and Mukherjee, Priyabrata, additional

Published
2022
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13. Database and Comparative Identification of Prophages

Author

Srividhya, K. V., Rao, Geeta V, Raghavenderan, L, Mehta, Preeti, Prilusky, Jaime, Manicka, Sankarnarayanan, Sussman, Joel L., Krishnaswamy, S, Thoma, M., editor, Morari, M., editor, Huang, De-Shuang, editor, Li, Kang, editor, and Irwin, George William, editor

Published
2006
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14. Maternal Footprints of Southeast Asians in North India

Author

Thangaraj, Kumarasamy, Chaubey, Gyaneshwer, Kivisild, Toomas, Rani, Deepa Selvi, Singh, Vijay Kumar, Ismail, Thanseem, Carvalho-Silva, Denise, Metspalu, Mait, Bhaskar, L.V.K.S., Reddy, Alla G., Chandra, Sarat, Pande, Veena, Naidu, B. Prathap, Adarsh, Niharika, Verma, Abhilasha, Jyothi, Inaganti Amara, Mallick, Chandana Basu, Shrivastava, Nidhi, Devasena, Ragala, Kumari, Babita, Singh, Amit Kumar, Dwivedi, Shailendra Kumar Dhar, Singh, Shefali, Rao, Geeta, Gupta, Pranav, Sonvane, Vartika, Kumari, Kavita, Basha, Afsar, Bhargavi, K.R., Lalremruata, Albert, Gupta, Arvind Kumar, Kaur, Gurukamal, Reddy, K.K., Rao, A. Papa, Villems, Richard, Tyler-Smith, Chris, and Singh, Lalji

Published
2008

19. Targeting the TGFβ pathway in uterine carcinosarcoma

Author

Dwivedi, Shailendra Kumar Dhar, primary, Rao, Geeta, additional, Dey, Anindya, additional, Buechel, Megan, additional, Zhang, Yushan, additional, Zhang, Min, additional, Yang, Da, additional, Mukherjee, Priyabrata, additional, and Bhattacharya, Resham, additional

Published
2020
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20. Micro RNA ‐195 controls MICU 1 expression and tumor growth in ovarian cancer

Author

Rao, Geeta, primary, Dwivedi, Shailendra Kumar Dhar, additional, Zhang, Yushan, additional, Dey, Anindya, additional, Shameer, Khader, additional, Karthik, Ramachandran, additional, Srikantan, Subramanya, additional, Hossen, Md Nazir, additional, Wren, Jonathan D, additional, Madesh, Muniswamy, additional, Dudley, Joel T, additional, Bhattacharya, Resham, additional, and Mukherjee, Priyabrata, additional

Published
2020
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21. Ubiquitin‐binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer

Author

Xiong, Xunhao, primary, Rao, Geeta, additional, Roy, Ram Vinod, additional, Zhang, Yushan, additional, Means, Nicolas, additional, Dey, Anindya, additional, Tsaliki, Martha, additional, Saha, Sounik, additional, Bhattacharyya, Sanjib, additional, Dhar Dwivedi, Shailendra Kumar, additional, Rao, Chinthalapally V., additional, McCormick, Daniel J., additional, Dhanasekaran, Danny, additional, Ding, Kai, additional, Gillies, Elizabeth, additional, Zhang, Min, additional, Yang, Da, additional, Bhattacharya, Resham, additional, and Mukherjee, Priyabrata, additional

Published
2020
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25. KRCC1: A potential therapeutic target in ovarian cancer

Author

Dwivedi, Shailendra Kumar Dhar, primary, Shameer, Khader, additional, Dey, Anindya, additional, Mustafi, Soumyajit Banerjee, additional, Xiong, Xunhao, additional, Bhattacharya, Udayan, additional, Neizer‐Ashun, Fiifi, additional, Rao, Geeta, additional, Wang, Yue, additional, Ivan, Cristina, additional, Yang, Da, additional, Dudley, Joel T., additional, Xu, Chao, additional, Wren, Jonathan D., additional, Mukherjee, Priyabrata, additional, and Bhattacharya, Resham, additional

Published
2019
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30. MicroRNA‐195 controls MICU1 expression and tumor growth in ovarian cancer.

Author

Rao, Geeta, Dwivedi, Shailendra Kumar Dhar, Zhang, Yushan, Dey, Anindya, Shameer, Khader, Karthik, Ramachandran, Srikantan, Subramanya, Hossen, Md Nazir, Wren, Jonathan D, Madesh, Muniswamy, Dudley, Joel T, Bhattacharya, Resham, and Mukherjee, Priyabrata

Abstract

MICU1 is a mitochondrial inner membrane protein that inhibits mitochondrial calcium entry; elevated MICU1 expression is characteristic of many cancers, including ovarian cancer. MICU1 induces both glycolysis and chemoresistance and is associated with poor clinical outcomes. However, there are currently no available interventions to normalize aberrant MICU1 expression. Here, we demonstrate that microRNA‐195‐5p (miR‐195) directly targets the 3′ UTR of the MICU1 mRNA and represses MICU1 expression. Additionally, miR‐195 is under‐expressed in ovarian cancer cell lines, and restoring miR‐195 expression reestablishes native MICU1 levels and the associated phenotypes. Stable expression of miR‐195 in a human xenograft model of ovarian cancer significantly reduces tumor growth, increases tumor doubling times, and enhances overall survival. In conclusion, miR‐195 controls MICU1 levels in ovarian cancer and could be exploited to normalize aberrant MICU1 expression, thus reversing both glycolysis and chemoresistance and consequently improving patient outcomes. Synopsis: miR‐195 represses MICU1 expression in ovarian cancer, thus reversing both glycolysis and chemoresistance and consequently improving patient survival. miR‐195 might thus be a potential tool for ovarian cancer therapy. MICU1 expression is characteristic of many cancers and is associated with poor clinical outcomes.miR‐195 inhibits MICU1 expression.Restoring miR‐195 expression in ovarian cancer cell lines reestablishes native MICU1 expression levels and the associated phenotypes.miR‐195 could be a potential therapeutic tool that could help translating MICU1‐targeted therapy into clinical care. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer.

Author

Xunhao Xiong, Rao, Geeta, Roy, Ram Vinod, Zhang, Yushan, Means, Nicolas, Dey, Anindya, Tsaliki, Martha, Saha, Sounik, Bhattacharyya, Sanjib, Dwivedi, Shailendra Kumar Dhar, Rao, Chinthalapally V., McCormick, Daniel J., Dhanasekaran, Danny, Kai Ding, Gillies, Elizabeth, Min Zhang, Da Yang, Bhattacharya, Resham, and Mukherjee, Priyabrata

Abstract

Macropinocytosis supports the metabolic requirement of RAS-transformed pancreatic ductal adenocarcinoma cells (PDACs). However, regulators of RAS-transformation (activation) that lead to macropinocytosis have not been identified. Herein, we report that UBAP2 (ubiquitin-binding associated protein 2), regulates the activation of KRAS and macropinocytosis in pancreatic cancer. We demonstrate that UBAP2 is highly expressed in both pancreatic cancer cell lines and tumor tissues of PDAC patients. The expression of UBAP2 is associated with poor overall survival in several cancers, including PDAC. Silencing UBAP2 decreases the levels of activated KRAS, and inhibits macropinocytosis, and tumor growth in vivo. Using a UBAP2-deletion construct, we demonstrate that the UBA-domain of UBAP2 is critical for the regulation of macropinocytosis and maintaining the levels of activated KRAS. In addition, UBAP2 regulates RAS downstream signaling and helps maintain RAS in the GTP-bound form. However, the exact mechanism by which UBAP2 regulates KRAS activation is unknown and needs further investigation. Thus, UBAP2 may be exploited as a potential therapeutic target to inhibit macropinocytosis and tumor growth in activated KRAS-driven cancers. [ABSTRACT FROM AUTHOR]

Published
2020
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32. KRCC1: A potential therapeutic target in ovarian cancer.

Author

Dwivedi, Shailendra Kumar Dhar, Shameer, Khader, Dey, Anindya, Mustafi, Soumyajit Banerjee, Xiong, Xunhao, Bhattacharya, Udayan, Neizer‐Ashun, Fiifi, Rao, Geeta, Wang, Yue, Ivan, Cristina, Yang, Da, Dudley, Joel T., Xu, Chao, Wren, Jonathan D., Mukherjee, Priyabrata, and Bhattacharya, Resham

Published
2020
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35. Cystathionine β‐synthase regulates mitochondrial morphogenesis in ovarian cancer

Author

Kumar Chakraborty, Prabir, primary, Murphy, Brennah, additional, Banerjee Mustafi, Soumyajit, additional, Dey, Anindya, additional, Xiong, Xunhao, additional, Rao, Geeta, additional, Naz, Sarwat, additional, Zhang, Min, additional, Yang, Da, additional, Dhanasekaran, Danny N., additional, Bhattacharya, Resham, additional, and Mukherjee, Priyabrata, additional

Published
2018
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36. Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors

Author

Yadav, Manisha, primary, Singh, Abhishek Kumar, additional, Kumar, Harish, additional, Rao, Geeta, additional, Chakravarti, Bandana, additional, Gurjar, Anagha, additional, Dogra, Shalini, additional, Kushwaha, Sapana, additional, Vishwakarma, Achchhe Lal, additional, Yadav, Prem Narayan, additional, Datta, Dipak, additional, Tripathi, Anil Kumar, additional, Chattopadhyay, Naibedya, additional, Trivedi, Arun Kumar, additional, and Sanyal, Sabyasachi, additional

Published
2016
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37. Scanning behavior in novel environments promotes de novo formation of hippocampal place fields in rats

Author

Monaco, Joseph, Rao, Geeta, Roth, Eric D., and Knierim, James J.

Abstract

This is a poster that was presented on November 12, 2013, at the Society for Neuroscience meeting in San Diego, CA: J. Monaco, G. Rao, E. D. Roth, J. J. Knierim. "Scanning behavior in novel environments promotes de novo formation of hippocampal place fields in rats". Soc Neurosci Abstr 2013, 670.07. The hippocampus is thought to play a critical role in episodic memory by incorporating the sensory input of an experience onto a spatial framework embodied by place cells. While the development of a new place field map has been shown to occur rapidly with experience [1], the interaction between discrete exploratory behaviors and the specific, immediate, and persistent modifications of neural representations required by episodic memory has not been established. We previously examined the relationship between place-field potentiation, a form of rate remapping, and head scanning behavior [2]. Here we investigate whether there is a similar interaction between head scanning and the formation of de novo place fields when the animals are first introduced to a completely novel environment. Place fields recorded in novel rooms [3] demonstrate both onset and, in some recordings, additional post-onset potentiation related to colocalized scanning activity on the prior lap. These results strongly suggest that, during the attentive behaviors that animals use to investigate their environments during exploration, place-cell activity mediates the one-trial encoding of ongoing experiences necessary for episodic memory. The phenomenon of head scan–activation of place fields occurs during an animal’s first exploratory session in a novel environment, extending our previous results from familiar and altered environments [2]. Our results demonstrate that place-cell activity during scanning behavior is involved in more than just the recall of place fields previously formed during forward locomotion, because higher-than-expected scan firing often precedes and predicts the development of new place fields in the novel environment. We suggest that pauses to execute head scans are a functionally significant component of navigation by intermittent locomotion [4], a widely observed exploratory strategy thought to balance internally-generated movement with the acquisition of external sensory information [5]. Place field modulation by head scans is consistent with the idea that a critical function of the hippocampal cognitive map is to encode a dynamic record of ongoing experience tied to attentive exploration of the external world. [1] Frank LM, Stanley GB, Brown EN. J Neurosci 24(35), 7681–9 (2004)[2] Monaco JD, Rao G, Knierim JJ. Soc Neurosci Abstr 97.13 (2011)[3] Roth ED, Yu X, Rao G, Knierim JJ. PLoS One 7(4), e36035 (2012)[4] Kramer DL, McLaughlin RL. Am Zool 41(2), 137–53 (2001)[5] Golani I, Benjamini Y, Eilam D. Behav Brain Res 53(1–2), 21–33 (1993); Tchernichovski O, Benjamini Y, Golani I. Biol Cybern, 78(6),423–32 (1998)

Published
2014
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