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This article discusses a case of a 2.5-year-old child with undiagnosed long QT syndrome (LQTS) who experienced cardiac arrest during a cochlear implant surgery. The child had a history of breath-holding spells and global developmental delay, but no active treatment was advised. The surgery was uneventful, but the child suddenly became unresponsive in the post-anesthesia care unit and developed torsade de pointes (TdP), a life-threatening arrhythmia. Despite resuscitation efforts, the child ultimately succumbed to refractory cardiogenic shock. The article emphasizes the importance of considering LQTS in pediatric patients with syncope history and avoiding drugs that can prolong the QT interval during the perioperative period. [Extracted from the article]

Simple hydroxide precursors were used for the first time for the synthesis of a typical Aurivillius compound (SrBi2Nb2O9 (SBN)) at a low temperature. This method is very advantageous because it circumvents the use of SrCO3 in the case of conventional ceramics as well in the coprecipitation methods, thereby lowering the formation of the product phase. Commercially purchased strontium hydroxide is mixed thoroughly with freshly precipitated bismuth and niobium hydroxides in a stoichiometric ratio and heated at different temperatures ranging from 100°C to 750°C for 12 h. The sequence of the reaction and evolution of the product phase was monitored by X-ray diffraction (XRD) studies by recording the XRD for samples calcined at different temperatures. The incipient SBN phase begins to form at temperatures as low as 400°C, and phase formation was complete only at 650°C as revealed by the XRD observations. The differential thermal/thermogravimetric analyses) also corroborate this result. The morphology and average particle size of these powders were investigated by transmission electron microscopy studies. [ABSTRACT FROM AUTHOR]

Low peak-to-average-power ratio (PAPR) transmissions significantly improve the cell coverage as they enable high power transmissions without saturating the power amplifier. To support the low PAPR transmissions, π/2-BPSK-based data and DMRS are introduced in the latest version of 5G NR specifications. In addition to that, the spatial multiplexing support is also extended to π/2-BPSK data transmissions. The DMRS sequences corresponding to these spatial streams (users) are frequency division multiplexed (FDM). However, the spectrum shaping process employed in the generation of π/2-BPSK waveforms is frequency selective and hence results in asymmetric spectrum shaping effect on DMRS sequences, when they are frequency multiplexed. This subsequently results in a non-uniform block error (BLER) and PAPR performances across the spatial users, which in turn may result in inter user interference across the spatial users. In this paper, we propose two transmitter architectures, namely method 1 and method 2, to generate low PAPR π/2-BPSK-based DMRS waveforms. The proposed architectures ensure that the spectrum shaping effect is uniform across all the spatial streams. We corroborate through simulations that the proposed architectures will result in identical block error and PAPR performances across all the spatial streams. [ABSTRACT FROM AUTHOR]

The outer atmosphere of the sun - called the corona - has been observed during total solar eclipse for short periods (typically < 6 min), from as early as the eighteenth century. In the recent past, space-based instruments have permitted us to study the corona uninterruptedly. In spite of these developments, the dynamic corona and its high temperature (1-2 million K) are yet to be fully understood. It is conjectured that their dynamic nature and associated energetic events are possible reasons behind the high temperature. In order to study these in detail, a visible emission line space solar coronagraph is being proposed as a payload under the small-satellite programme of the Indian Space Research Organisation. The satellite is named as Aditya-1 and the scientific objectives of this payload are to study: (i) the existence of intensity oscillations for the study of wavedriven coronal heating; (ii) the dynamics and formation of coronal loops and temperature structure of the coronal features; (iii) the origin, cause and acceleration of coronal mass ejections (CMEs) and other solar active features, and (iv) coronal magnetic field topology and three-dimensional structures of CMEs using polarization information. The uniqueness of this payload compared to previously flown space instruments is as follows: (a) observations in the visible wavelength closer to the disk (down to 1.05 solar radii); (b) high time cadence capability (better than two-images per second), and (c) simultaneous observations of at least two spectral windows all the time and three spectral windows for short durations. [ABSTRACT FROM AUTHOR]

Background:Multi drug resistant and rifampicin resistant TB patients in India are treated with the World Health Organization (WHO) recommended standardized treatment regimens but no guidelines are available for the management of isoniazid (INH) resistant TB patients. There have been concerns that the standard eight-month retreatment regimen being used in India (2H3R3Z3E3S3/1H3R3Z3E3/5H3R3E3; H-Isoniazid; R-Rifampicin; Z-Pyrazinamide; E-Ethambutol; S-Streptomycin) may be inadequate to treat INH resistant TB cases and leads to poor treatment outcomes. We aimed to assess if INH resistance is associated with unfavorable treatment outcomes (death, default, failure and transferred out) among a cohort of smear positive retreatment TB patients registered in three districts of Andhra Pradesh, India. Methods:We conducted a retrospective record review of all smear positive retreatment TB patients without rifampicin resistance registered during April–December 2011. Results:Of 1,947 TB patients, 1,127 (58%) were tested with LPA—50 (4%) were rifampicin resistant, 933 (84%) were sensitive to INH and rifampicin and 144 (12%) were INH resistant. Of 144 INH resistant cases, 64 (44%) had poor treatment outcomes (25 (17%) default, 22 (15%) death, 12 (8%) failure and 5 (3%) transfer out) as compared to 287 (31%) among INH sensitive cases [aRR 1.46; 95%CI (1.19–1.78)]. Conclusion:Our study confirms that INH resistance is independently associated with unfavorable treatment outcomes among smear positive retreatment TB patients, indicating that the current treatment regimen may be inadequate. These findings call for an urgent need for randomized controlled trials to discover the most effective treatment regimen for managing INH resistant TB. [ABSTRACT FROM AUTHOR]