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This paper presents thorough computational and theoretical analyses of steady forced convective flow over a rotating disc submerged in a water-based nanofluid containing microorganisms. It delves into the examination of boundary layer flow characteristics of a viscous nanofluid, considering Stefan blowing effects and multiple slip conditions influenced by a magnetic field. Notably, the study accounts for novel aspects such as thermal radiation and both constructive and destructive chemical reactions. The movement of nanoparticles is elucidated based on thermophoresis and microscopic behaviors, while changes in volume fraction do not affect the thermo-physical properties of the nanofluid. To address the altered nonlinear set of differential equations, an effective numerical approach, the Keller-Box method, is implemented for critical and efficient solutions. These appropriate transformations are defined and applied. When compared to blowing suction, it shows a better enhancement in the rate of heat transfer, mass, and microorganisms. Some of the main observations are there is a decrease in wall skin friction in the directions of radial and tangential as magnetic field strength is increased. The evaluation of thermal boundary layer thickness and temperature is noted for the radiation parameter (Rd) improvement. The present analysis has applications in electromagnetic micro-pumps and nanomechanics. As to the applications in the science and engineering fields, technologies such as micro-electromechanical systems-based microfluidic devices and microfluidic-related technologies will be accepted. [ABSTRACT FROM AUTHOR]