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This study examines how a chemical reaction and a nonuniform heat source effect the flow of an MHD Casson nanofluid over a nonlinear stretching sheet. By incorporating viscous dissipation, the energy equation is strengthened. Brownian diffusion, thermophoresis diffusion effects are taken place. By using the necessary similarity transformations, the governing equations for the current flow are converted into a nonlinear system. The RKF technique yields a numerical solution along with a shooting technique for the condensed system. Thereafter, to better understand the physical interpretation of flow and heat transfer, the flow-controlling parameters are shown graphically and in tabular form in the current work. Based on the present study's numerical results, a fair connection is found between this analysis and previous studies. Some of the observations are velocity profile is decreased for the effects of magnetics and stretching parameter variations and Eckert number plays a great role in the increase of temperature profile. [ABSTRACT FROM AUTHOR]