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9. The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy: a randomized controlled trial

Author

Gurunathan, Usha, Rapchuk, Ivan L., King, Gillian, Barnett, Adrian G., and Fraser, John F.

Subjects
Nonsteroidal anti-inflammatory agents -- Analysis -- Research, Pregabalin -- Analysis -- Research, Cholecystectomy -- Research -- Health aspects, Health
Abstract

Purpose Early postoperative pain is a common complaint after elective laparoscopic cholecystectomy. The use of non-opioid medications as a part of multimodal analgesia has been increasingly advocated in the management of acute post-surgical pain. This randomized, double-blinded, placebo-controlled study evaluated the efficacy of pregabalin, celecoxib, and their combination in the management of acute postoperative pain in patients undergoing elective laparoscopic cholecystectomy. Methods One hundred ASA I/II patients scheduled to undergo elective laparoscopic cholecystectomy were assigned to receive two perioperative doses, 12 h apart, of either pregabalin alone, celecoxib alone, their combination, or a placebo. Standard anesthetic protocol was followed. The primary outcomes were postoperative pain at rest and with movement. Secondary outcomes were fentanyl requirements and side effects, which were assessed at 1, 2, 4, 8, 12, and 24 h following surgery. Patient satisfaction with pain relief was recorded at discharge. Differences in main outcomes were analyzed using an intention-to-treat approach. Results There was no statistically significant difference (p > 0.05) between the four groups in terms of outcomes such as rest pain, movement pain, postoperative fentanyl requirements, or changes in anxiety scores. Patients who had only celecoxib had significantly higher satisfaction with pain management (p = 0.013). Patients who had only pregabalin were at three-times-higher odds of having drowsiness (p = 0.040) and four-times-higher odds of having lightheadedness (p = 0.019) when compared with the placebo group. Conclusions Pregabalin, celecoxib alone, or in combination offers no analgesic superiority over standard opioid care in the treatment of postoperative pain following laparoscopic cholecystectomy., Author(s): Usha Gurunathan[sup.1] , Ivan L. Rapchuk[sup.1] , Gillian King[sup.2] , Adrian G. Barnett[sup.3] , John F. Fraser[sup.4] Author Affiliations: (1) Department of Anesthesia and Perfusion Services, The Prince Charles [...]

Published
2016
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14. Prophylactic post-operative high flow nasal oxygen versus conventional oxygen therapy in obese patients undergoing bariatric surgery (OXYBAR study): a pilot randomised controlled trial

Author

Fulton, Rachel, primary, Millar, Jonathan E, additional, Merza, Megan, additional, Johnston, Helen, additional, Corley, Amanda, additional, Faulke, Daniel, additional, Rapchuk, Ivan L, additional, Tarpey, Joe, additional, Fanning, Jonathon P, additional, Lockie, Philip, additional, Lockie, Shirley, additional, and Fraser, John F, additional

Published
2021
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16. Abstract

Author

Chhina, Tejinder S., Lapierre, Harry, Jackson, Zane S., Leong-Poi, Howard M., Teitel, Jerome M., Latter, David A., Strauss, Bradley H., Gross, Peter L., Mazer, C. David, Brull, Richard, McCartney, Colin J. L., Abbas, Sherif, Nova, Hugo, Rawson, Regan, Chan, Vincent W. S., Katz, Joel, Graham, Brent, Anastakis, Dimitri, von Schroeder, Herbert, Lallo, Alexandre, Drolet, Pierre, Lacroix, Mélanie, You-Ten, Kong E., Caraiscos, Valerie B., Elliot, Erin M., Cheng, Victor Y., MacDonald, John F., Orser, Beverley A., Lau, Bertrand, Tsui, Ban C. H., Mollison, Heather L., McKay, William P. S., Patel, Rajesh, Chow, Vance, Negraeff, October, Karam, Rana, Yang, H., Raymer, K., Butler, R., Parlow, J., Roberts, R., Campbell, David C., Breen, Terrance W., Halpern, Stephen, Muir, Holly, Nunn, Robert, Katznelson, Rita, Karkouti, Keyvan, Ghannam, Mohammed, Abdelnaem, Esam, Carroll, Jo, McCluskey, Stuart, Yau, Terrence M., Karski, Jacek, Hare, Gregory M. T., Li, Xiamao, Qu, Rong, Cheung, May S. M., Coackley, Carla, Baker, Andrew J., Ronayne, Michael, Song, Dajun, Chung, Frances, Ward, Barnaby, Yogendran, Suntheralingam, Sibbick, Carolyn, Silcox, Lisa C., Ashbury, Ted L., Milne, Brian, VanDen Kerkhof, Elizabeth G., Morgan, Pamela J., Cleave-Hogg, Doreen, DeSousa, Susan, Wang, Louie, Lujic, Jelka, Donnelly, Niamh I., Torok-Both, Clint J., Finegan, Barry, Jacka, Michael J., Finegan, Barry A., Chawla, Rajiv, Agrawal, Ravi K., Kumar, Mahendra, Goldstein, David H., Paul, James E., Sawhney, Monakshi, Beattie, W. Scott, McLean, Richard F., Parlow, Joel L., Tod, Deborah A., Souzdalnitski, Dmitri, Sourovtseva, Elena, Livingstone, Donald, Faclier, Gil, Sawyer, Jason, Kay, Joseph, Avila, Arsenio, Balki, Mrinalini, Manninen, Pirjo H., Lukitto, Karolinah, Lukins, Michael B., Quader, Keya, Agarwal, Munisha, Kawatra, Rakhi, Dali, J. S., Mak, Peter H., Jose, Geraldine, Hall, Sean R., Wang, Louie, Hong, Murray, Rapchuk, Ivan L., Loo, Karen, Deschamps, Alain, Suzuki, Asaha, Kanai, Akifumi, Hoka, Sumio, Ho, Anthony M. -H., Karmakar, Manoj K., Lee, Anna, Samy, Winnie, Yi, Jie, Lai, Paul B. S., Cho, Amy, Stockton, E., Gowrie-Mohan, S., Ramanayake, P. U., Jothilingam, S., Mirmansouri, Ali, Wagner, Alese M., Cunningham, Kirsten, Perry, Shirley, Desai, Sunil, Torok-Both, Clint, DeKoven, Kathryn, Deschamps, Alain, Brousseau, Paul, Hung, Orlando, Law, Adam, Levangie, Derek, Cheverie, Ronald, Caputo, Karen M., Byrick, Robert, Chapman, Martin, Vicente, Kim, Atlas, Glen, Léveillé, Josiane, Côté, Dany, Soucy, Julie, Bussières, Jean S., Wijeysundera, Duminda N., Djaiani, George, Rao, Vivek, Borger, Michael A., Cusimano, Robert J., Moghadam, Anoush D., Heydarzadeh, Abtin, Fayad, Ashraf A., Yang, Homer, Ling, Elizabeth, Tenenbein, Paul K., Maguire, Doug, Debrouwere, Roland, Duke, Peter C., Kowalski, Stephen E., Chakravarty, Devashish, Dupuis, Jean-Yves, Nathan, Howard, Rubens, Fraser, Masters, Roy, Hendry, Paul, Mesana, Thierry, Jung, Hyun Ju, Chamchad, Dmitri, Arkoosh, Valerie, Wijeysundera, Duminda, Chan, Chris, Datillo, Kathleen, Ivano, Joan, Clark, Cantwell, Quinn, Reed D., Braxton, John H., Taenzer, Andreas H., Sullivan, Kristen M., Al-Abdulhadi, Osama A., Biehl, Diane R., Ong, Bill Y., Boker, Abdulaziz, Stewart, Kristine I., Shaw, Susan A., Hong, Jeong-Yeon, Morgan, Pamela J., Palmer, Susan K., Kung, Rose, Halpern, Stephen H., Yee, Jennifer A., Goldszmidt, Eric, Chettle, Crystal, Kern, Ralph, Downey, Kristi, Devito, Isabella, Macarthur, Alison, Purdie, Niall L., Angle, Pamela J., Kurtz-Landy, Christine, Streiner, David, Charles, Cathy, Kung, Rose, MacDonnell, Jo Watson, Lam, Desmond, Lie, Lie Ming, Kronberg, Jean E., Thompson, Dorothy E., Dong, Haiheng, Hyder, Ayman, Wang, Qinghua, Lu, Wei-Yang, Imasogie, Ngozi N., Chung, Frances, Prahbu, Atul, Curti, Bruna, Potyomkina, Zoya, Belmont, Matthew R., Tjan, Joseph, Lien, Cynthia A., Patel, Sanjay, Imarengiaye, Charles, Peirovy, Javad, Edward, Reginald, Chung, Frances F., Kayumov, Leonid, Sinclair, David R., Moller, Henry J., Shapiro, Colin M., Michaud, Guillaume, Trager, Guillaume, Deschamps, Stephane, Hemmerling, Thomas M., Hsu, Janet, Cheng, Patrick, Granton, John T., Baxter, Alan D., Kanji, Salmaan, Oxner, Adam D., Buth, Karen J., Hirsch, Gregory M., DiQuinzio, Claudio, Hirsch, Kristine A., Denault, A., Couture, P., Carrier, M., Fortier, A., Babin, D., Tardif, J. C., Olivier, Jean-François, Basile, Fadi, Prieto, Ignatio, Lê, Nhiên, Hirasaki, Yuji, Murphy, Patricia, McRae, Karen, Waddell, Thomas, Keshavjee, Shaf, Slinger, Peter, Van Rensburg, Adriaan, Yau, Terry M., Yeo, Eric, Sutton, David, Borger, Michael, Blaise, Gilbert, Gangal, Marius D., Gao, Lan, McCluskey, Stuart A., Cheung, Wing, Metha, Bobby, Poonwala, Humara, Fedorko, Ludwik, Symon, Johnson R., Peterson, Mark D., Leipoldt, Carl C. P., Clunie, Michelle, Mckay, William P. S., Miller, Grant, Guay, Joanne, Lortie, Louise, Son, Soochang, Kim, Yunhee, Arai, Toshimi, Yamashita, Masao, Rohan, Denise, Barlow, Ross, Barbour, Sean J., Ansermino, J. Mark, Vandebeek, Christine A., Raman, Rangamani K., Nakatsuka, Nao, Montgomery, Carolyne J., Skarsgard, Erik D., Court, Colleen A., Galton, James S., Crawford, Mark W., Naser, Basem, Carter, Clifford, Liu, Richard, Usher, Andrew G., Cave, Dominic A., Tang, Cathy, Hayes, Jason A., and Tan, Juliana M.

Published
2004
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19. Fluid resuscitation after cardiac surgery in the intensive care unit: A bi-national survey of clinician practice. (The FRACS-ICU clinician survey).

Author

Ramanan, Mahesh, Roberts, Shaun, Adrian McCullough, James, Naidoo, Rishendran, Rapchuk, Ivan, Matebele, Mbakise, Tabah, Alexis, Kruger, Peter, Smith, Julian, Shekar, Kiran, and Adrian McCullough, James Patrick

Subjects
INTENSIVE care units, MEDICAL personnel, CARDIAC intensive care, CARDIAC resuscitation, CARDIAC surgery, VASOCONSTRICTORS, FLUID therapy
Abstract

Context and Aims: To describe current fluid and vasopressor practices after cardiac surgery in Australia and New Zealand cardiothoracic intensive care units (ICU).Design and Setting: This web-based survey was conducted in cardiothoracic ICUs in Australia and New Zealand.Methods: Intensivists, cardiac surgeons, and anesthetists were contacted to complete the online survey that asked questions regarding first and second choice fluids and vasopressors and the tools and factors that influenced these choices.Results: There were 96 respondents including 51 intensivists, 27 anesthetists, and 18 cardiac surgeons. Balanced crystalloids were the most preferred fluids (70%) followed by 4% albumin (18%) overall and among intensivists and anesthetists; however, cardiac surgeons (41%) preferred 4% albumin as their first choice. The most preferred second choice was 4% albumin (74%). Among vasopressors, noradrenaline was the preferred first choice (93%) and vasopressin the preferred second choice (80%). 53% initiated blood transfusion at a hemoglobin threshold of 70 g/L. Clinical acumen and mean arterial pressure were the most commonly used modalities in determining the need for fluids.Conclusions: There is practice variation in preference for fluids used in cardiac surgical patients in Australia and New Zealand; however, balanced crystalloids and 4% albumin were the most popular choices. In contrast, there is broad agreement with the use of noradrenaline and vasopressin as first and second-line vasopressors. These data will inform the design of future studies that aim to investigate hemodynamic management post cardiac surgery. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Additional file 1: of High flow nasal oxygen after bariatric surgery (OXYBAR), prophylactic post-operative high flow nasal oxygen versus conventional oxygen therapy in obese patients undergoing bariatric surgery: study protocol for a randomised controlled pilot trial

Author

Fulton, Rachel, Millar, Jonathan, Merza, Megan, Johnston, Helen, Corley, Amanda, Faulke, Daniel, Rapchuk, Ivan, Tarpey, Joe, Lockie, Philip, Lockie, Shirley, and Fraser, John

Abstract

SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOCX 41 kb)

Published
2018
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22. Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy

Author

Adiraju, Santosh Kumar Sreevatsav, primary, Shekar, Kiran, additional, Tesar, Peter, additional, Naidoo, Rishendran, additional, Rapchuk, Ivan, additional, Belz, Stephen, additional, Fraser, John F, additional, Smith, Maree T, additional, and Ghassabian, Sussan, additional

Published
2019
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37. Complementary Practitioners’ View of Treatment for Inflammatory Bowel Disease

Author

J Verhoef, Marja, Rapchuk, Ivan, Liew, Trina, Weir, Vanessa, and J Hilsden, Robert

Abstract

A substantial number of patients with inflammatory bowel disease use complementary therapies to manage their disease, including chiropractic and herbal therapies. The objective of this study was to explore whether providers of these therapies see patients with inflammatory bowel disease and recommend therapies, and to determine their opinions about the treatments that they recommend. The study sample comprised 66 chiropractors, 19 pharmacists, 16 herbalists and 15 health food store employees in Calgary, Alberta. A structured questionnaire containing two patient scenarios (a patient with active ulcerative colitis and a patient with inactive Crohn’s disease) was completed either by an in-person interview or by a mailed questionnaire. Most respondents had seen patients with ulcerative colitis, and at least 80% of each group except pharmacists (only 10%) would treat these patients or recommend treatment. Almost all chiropractors used spinal manipulation, whereas herbalists and health food store employees suggested a wide range of different treatments. Chiropractors rated their treatment as moderately effective; herbalists and health food store employees viewed their recommendations as very effective. The results with respect to the second scenario were very similar. The wide range of treatment recommendations by practitioners, who differ greatly in terms of skills, knowledge and experience, has important implications for physician-patient communication, information provision and education regarding complementary and alternative therapies.

Published
2002
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