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2. Supplementary Table from A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma

Author

Rappold, Phillip M., primary, Vuong, Lynda, primary, Leibold, Josef, primary, Chakiryan, Nicholas H., primary, Curry, Michael, primary, Kuo, Fengshen, primary, Sabio, Erich, primary, Jiang, Hui, primary, Nixon, Briana G., primary, Liu, Ming, primary, Berglund, Anders E., primary, Silagy, Andrew W., primary, Mascareno, Eduardo A., primary, Golkaram, Mahdi, primary, Marker, Mahtab, primary, Reising, Albert, primary, Savchenko, Alexander, primary, Millholland, John, primary, Chen, Ying-Bei, primary, Russo, Paul, primary, Coleman, Jonathan, primary, Reznik, Ed, primary, Manley, Brandon J., primary, Ostrovnaya, Irina, primary, Makarov, Vladimir, primary, DiNatale, Renzo G., primary, Blum, Kyle A., primary, Ma, Xiaoxiao, primary, Chowell, Diego, primary, Li, Ming O., primary, Solit, David B., primary, Lowe, Scott W., primary, Chan, Timothy A., primary, Motzer, Robert J., primary, Voss, Martin H., primary, and Hakimi, A. Ari, primary

Published
2023
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3. Supplementary Figure from A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma

Author

Rappold, Phillip M., primary, Vuong, Lynda, primary, Leibold, Josef, primary, Chakiryan, Nicholas H., primary, Curry, Michael, primary, Kuo, Fengshen, primary, Sabio, Erich, primary, Jiang, Hui, primary, Nixon, Briana G., primary, Liu, Ming, primary, Berglund, Anders E., primary, Silagy, Andrew W., primary, Mascareno, Eduardo A., primary, Golkaram, Mahdi, primary, Marker, Mahtab, primary, Reising, Albert, primary, Savchenko, Alexander, primary, Millholland, John, primary, Chen, Ying-Bei, primary, Russo, Paul, primary, Coleman, Jonathan, primary, Reznik, Ed, primary, Manley, Brandon J., primary, Ostrovnaya, Irina, primary, Makarov, Vladimir, primary, DiNatale, Renzo G., primary, Blum, Kyle A., primary, Ma, Xiaoxiao, primary, Chowell, Diego, primary, Li, Ming O., primary, Solit, David B., primary, Lowe, Scott W., primary, Chan, Timothy A., primary, Motzer, Robert J., primary, Voss, Martin H., primary, and Hakimi, A. Ari, primary

Published
2023
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4. Data from A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma

Author

Rappold, Phillip M., primary, Vuong, Lynda, primary, Leibold, Josef, primary, Chakiryan, Nicholas H., primary, Curry, Michael, primary, Kuo, Fengshen, primary, Sabio, Erich, primary, Jiang, Hui, primary, Nixon, Briana G., primary, Liu, Ming, primary, Berglund, Anders E., primary, Silagy, Andrew W., primary, Mascareno, Eduardo A., primary, Golkaram, Mahdi, primary, Marker, Mahtab, primary, Reising, Albert, primary, Savchenko, Alexander, primary, Millholland, John, primary, Chen, Ying-Bei, primary, Russo, Paul, primary, Coleman, Jonathan, primary, Reznik, Ed, primary, Manley, Brandon J., primary, Ostrovnaya, Irina, primary, Makarov, Vladimir, primary, DiNatale, Renzo G., primary, Blum, Kyle A., primary, Ma, Xiaoxiao, primary, Chowell, Diego, primary, Li, Ming O., primary, Solit, David B., primary, Lowe, Scott W., primary, Chan, Timothy A., primary, Motzer, Robert J., primary, Voss, Martin H., primary, and Hakimi, A. Ari, primary

Published
2023
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6. A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma

Author

Rappold, Phillip M., primary, Vuong, Lynda, additional, Leibold, Josef, additional, Chakiryan, Nicholas H., additional, Curry, Michael, additional, Kuo, Fengshen, additional, Sabio, Erich, additional, Jiang, Hui, additional, Nixon, Briana G., additional, Liu, Ming, additional, Berglund, Anders E., additional, Silagy, Andrew W., additional, Mascareno, Eduardo A., additional, Golkaram, Mahdi, additional, Marker, Mahtab, additional, Reising, Albert, additional, Savchenko, Alexander, additional, Millholland, John, additional, Chen, Ying-Bei, additional, Russo, Paul, additional, Coleman, Jonathan, additional, Reznik, Ed, additional, Manley, Brandon J., additional, Ostrovnaya, Irina, additional, Makarov, Vladimir, additional, DiNatale, Renzo G., additional, Blum, Kyle A., additional, Ma, Xiaoxiao, additional, Chowell, Diego, additional, Li, Ming O., additional, Solit, David B., additional, Lowe, Scott W., additional, Chan, Timothy A., additional, Motzer, Robert J., additional, Voss, Martin H., additional, and Hakimi, A. Ari, additional

Published
2022
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12. MP39-09 GENOMIC CHARACTERIZATION OF AGGRESSIVE SPORADIC EPITHELIOID ANGIOMYOLIPOMA

Author

Rappold, Phillip M, primary, Zucker, Mark, additional, Yoo, Angela, additional, Davelman, Benjamin, additional, Weiss, Kate, additional, Russo, Paul, additional, Coleman, Jonathan, additional, Voss, Martin H, additional, Chan, Timothy A, additional, Motzer, Robert J, additional, Chen, Yingbei, additional, Reznik, Ed, additional, Tickoo, Satish K, additional, and Hakimi, A Ari, additional

Published
2021
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13. Prevalence and Landscape of Actionable Genomic Alterations in Renal Cell Carcinoma

Author

Attalla, Kyrollis, primary, DiNatale, Renzo G., additional, Rappold, Phillip M., additional, Fong, Christopher J., additional, Sanchez-Vega, Francisco, additional, Silagy, Andrew W., additional, Weng, Stanley, additional, Coleman, Jonathan, additional, Lee, Chung-Han, additional, Carlo, Maria I., additional, Durack, Jeremy C., additional, Solomon, Stephen B., additional, Reuter, Victor E., additional, Russo, Paul, additional, Chan, Timothy A., additional, Motzer, Robert J., additional, Schultz, Nikolaus D., additional, Reznik, Ed, additional, Voss, Martin H., additional, and Hakimi, A. Ari, additional

Published
2021
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14. Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

Author

Yoo, Angela, primary, Tang, Cerise, additional, Zucker, Mark, additional, Fitzgerald, Kelly, additional, Rappold, Phillip M, additional, Weiss, Kate, additional, Freeman, Benjamin, additional, Lee, Chung-Han, additional, Schultz, Nikolaus, additional, Motzer, Robert, additional, Russo, Paul, additional, Coleman, Jonathan, additional, Reuter, Victor E, additional, Chen, Ying-Bei, additional, Carlo, Maria I, additional, Gill, Anthony J, additional, Kotecha, Ritesh R, additional, Hakimi, A. Ari, additional, and Reznik, Ed, additional

Published
2021
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15. Therapy-relevant gene signatures in the high risk localized renal cell carcinoma setting: Transcriptomic data from patients receiving placebo on a randomized phase III trial (PROTECT).

Author

Rappold, Phillip M., primary, Silagy, Andrew W., additional, Kuo, Fengshen, additional, Marker, Mahtab, additional, Reising, Albert, additional, Millholland, John, additional, Russo, Paul, additional, Coleman, Jonathan, additional, Voss, Martin H., additional, Chan, Timothy A., additional, Motzer, Robert J., additional, and Hakimi, A. Ari, additional

Published
2021
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19. Critical role of aquaporin-4 (AQP4) in astrocytic Ca 2+ signaling events elicited by cerebral edema

Author

Thrane, Alexander S., primary, Rappold, Phillip M., additional, Fujita, Takumi, additional, Torres, Arnulfo, additional, Bekar, Lane K., additional, Takano, Takahiro, additional, Peng, Weiguo, additional, Wang, Fushun, additional, Rangroo Thrane, Vinita, additional, Enger, Rune, additional, Haj-Yasein, Nadia N., additional, Skare, Øivind, additional, Holen, Torgeir, additional, Klungland, Arne, additional, Ottersen, Ole P., additional, Nedergaard, Maiken, additional, and Nagelhus, Erlend A., additional

Published
2010
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20. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Author

Thrane, Alexander S., Rappold, Phillip M., Fujita, Takumi, Torres, Arnulfo, Bekar, Lane K., Takano, Takahiro, Weiguo Peng, Fushun Wang, Thrane, Vinita Rangroo, Enger, Rune, Haj-Yasein, Nadia N., Skare, Oivind, Holen, Torgeir, Klungland, Arne, Ottersen, Ole P., Nedergaard, Maiken, and Nagelhus, Erlend A.

Subjects
*AQUAPORINS, *GLYCOPROTEINS, *MEMBRANE proteins, *ASTROCYTES, *CELLS
Abstract

Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation. Here, we provide evidence that brain swelling triggers Ca2+ signaling in astrocytes and that deletion of the Aqp4 gene markedly interferes with these events. Using in vivo twophoton imaging, we show that hypoosmotic stress (20% reduction in osmolarity) initiates astrocytic Ca2+ spikes and that deletion of Aqp4 reduces these signals. The Ca2+ signals are partly dependent on activation of P2 purinergic receptors, which was judged from the effects of appropriate antagonists applied to cortical slices. Supporting the involvement of purinergic signaling, osmotic stress was found to induce ATP release from cultured astrocytes in an AQP4-dependent manner. Our results suggest that AQP4 not only serves as an influx route for water but also is critical for initiating downstream signaling events that may affect and potentially exacerbate the pathological outcome in clinical conditions associated with brain edema. [ABSTRACT FROM AUTHOR]

Published
2011
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