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3. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Author

van Grinsven, Janneke, van Brunschot, Sandra, Bakker, Olaf J., Bollen, Thomas L., Boermeester, Marja A., Bruno, Marco J., Dejong, Cornelis H., Dijkgraaf, Marcel G., van Eijck, Casper H., Fockens, Paul, van Goor, Harry, Gooszen, Hein G., Horvath, Karen D., van Lienden, Krijn P., van Santvoort, Hjalmar C., Besselink, Marc G., Abdelhafez, M, Andersson, R, Andren-Sandberg, A, Ashley, S, van Baal, M, Baron, T, Bassi, C, Bradley, E, Buchler, M, Cappendijk, V, Carter, R, Charnley, R, Coelho, D, Connor, S, Dellinger, P, Dervenis, C, Deviere, J, Doctor, N, Dudeja, V, En-qiang, M, Escourrou, J, Fagenholz, P, Farkas, G, Forsmark, C, Freeman, M, Freeny, P, French, J, Friess, H, Gardner, T, Goetzinger, P, Haveman, J, Hofker, S, Imrie, C, Isaji, S, Isenmann, R, Klar, E, Laméris, J, Lerch, M, Lévy, P, Lillemoe, K, Löhr, M, Mayerle, J, Mayumi, T, Mittal, A, Moessner, J, Morgan, D, Mortele, K, Nealon, W, Neoptolemos, J, Nieuwenhuijs, V, Nordback, I, Olah, A, Oppong, K, Padbury, R, Papachristou, G, Parks, R, Poley, J, Radenkovic, D, Raraty, M, Rau, B, Rebours, V, Rische, S, Runzi, M, Sainani, N, Sarr, M, Schaapherder, S, Seewald, S, Seifert, H, Shimosegawa, T, Silverman, S, Singh, V, Siriwardena, A, Steinberg, W, Sutton, R, Takeda, K, Timmer, R, Vege, S, Voermans, R, de Waele, J, Wang, Ch, Warshaw, A, Werner, J, Weusten, B, Whitcomb, D, Wig, J, Windsor, J, and Zyromski, N

Published
2015
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28. Abstracts from the twenty-third meeting of the pancreatic society of Great Britain and Ireland at the Village Hotel, Leeds, UK

Author

Johnson, C. D., Ammori, B J, Davides, D, Vezakis, A, Larvin, M, McMahon, K J, Powell, J J, Hill, G, Storey, S, Murchison, J, Fearon, K, Ross, J, Siriwardena, A K, Pearce, N W, Smithies, A. M., Sargen, K., Demaine, A. G., Kingsnorth, A. N., Becker, K L, Kite, P, Barclay, G R, Snider, R H, Nylen, E S, White, J C, Martin, I G, McMahon, M J, Raraty, M GT, Ward, J B, Vaillant, C, Neoptolemos, J P, Sutton, R, Petersen, O H, Creighton, J. E., Lyall, R., Wilson, D. I., Curtis, A., Charnley, R. M., Howes, N, Rutherford, S, McRonald, F, Ellis, I., Whitcomb, D, Mountford, R, Larvin, M., Manu, M, Bramhall, S R, Gur, U, Gunson, B K, Le Cornu, K J, Mayer, A D, Mirza, D F, McMaster, P, Buckets, J A C, King, L J, Bell, J R G, Healy, J. C., Amin, Z, Predolac, D, Wotherspoon, A, Thompson, J, Norton, S A, Alderson, D, Kawesha, A, Ghaneh, P, Evans, J D, Campbell, Dawiskiba, S, Lemoine, N R, Andrén-Sandberg, A, Humphreys, M, Greenhalf, W., Stoner, E A, Piotrowicz, A J K, Evans, D F, Ainley, C C, White, S A, Pollard, C, Burden, A C, Clayton, H A, Davies, J E, Swift, S M, Hales, C N, Dennison, A R, London, N J M, Sutton, C D, White, S, Berry, D P, Chillistone, D, Rees, Y, Ammann, R. W., Heitz, Ph. U., Klöppel, G., Bimmler, Daniel, Graf, Rolf, and Frick, Thomas W.

Published
1999
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29. Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer

Author

Sheel, A. R. G., primary, Harrison, S., additional, Sarantitis, I., additional, Nicholson, J. A., additional, Hanna, T., additional, Grocock, C., additional, Raraty, M., additional, Ramesh, J., additional, Farooq, A., additional, Costello, E., additional, Jackson, R., additional, Chapman, M., additional, Smith, A., additional, Carter, R., additional, Mckay, C., additional, Hamady, Z., additional, Aithal, G. P., additional, Mountford, R., additional, Ghaneh, P., additional, Hammel, P., additional, Lerch, M. M., additional, Halloran, C., additional, Pereira, S. P., additional, and Greenhalf, W., additional

Published
2019
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31. Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: a pooled analysis of individual data for 1980 patients

Author

Brunschot, S. van, Hollemans, R.A., Bakker, O.J., Besselink, M.G.H., Baron, T.H., Beger, H.G., Boermeester, M.A., Bollen, T.L., Bruno, M.J., Carter, R., French, J.J., Coelho, D., Dahl, B., Dijkgraaf, M.G., Doctor, N., Fagenholz, P.J., Farkas, G., Castillo, C.F.D., Fockens, P., Freeman, M.L., Gardner, T.B., Goor, H. van, Gooszen, H.G., Hannink, G.J., Lochan, R., McKay, C.J., Neoptolemos, J.P., Olah, A., Parks, R.W., Peev, M.P., Raraty, M., Rau, B., Rosch, T., Rovers, M.M., Seifert, H., Siriwardena, A.K., Horvath, K.D., Santvoort, H.C. van, Brunschot, S. van, Hollemans, R.A., Bakker, O.J., Besselink, M.G.H., Baron, T.H., Beger, H.G., Boermeester, M.A., Bollen, T.L., Bruno, M.J., Carter, R., French, J.J., Coelho, D., Dahl, B., Dijkgraaf, M.G., Doctor, N., Fagenholz, P.J., Farkas, G., Castillo, C.F.D., Fockens, P., Freeman, M.L., Gardner, T.B., Goor, H. van, Gooszen, H.G., Hannink, G.J., Lochan, R., McKay, C.J., Neoptolemos, J.P., Olah, A., Parks, R.W., Peev, M.P., Raraty, M., Rau, B., Rosch, T., Rovers, M.M., Seifert, H., Siriwardena, A.K., Horvath, K.D., and Santvoort, H.C. van

Abstract

Item does not contain fulltext, OBJECTIVE: Minimally invasive surgical necrosectomy and endoscopic necrosectomy, compared with open necrosectomy, might improve outcomes in necrotising pancreatitis, especially in critically ill patients. Evidence from large comparative studies is lacking. DESIGN: We combined original and newly collected data from 15 published and unpublished patient cohorts (51 hospitals; 8 countries) on pancreatic necrosectomy for necrotising pancreatitis. Death rates were compared in patients undergoing open necrosectomy versus minimally invasive surgical or endoscopic necrosectomy. To adjust for confounding and to study effect modification by clinical severity, we performed two types of analyses: logistic multivariable regression and propensity score matching with stratification according to predicted risk of death at baseline (low: <5%; intermediate: >/=5% to <15%; high: >/=15% to <35%; and very high: >/=35%). RESULTS: Among 1980 patients with necrotising pancreatitis, 1167 underwent open necrosectomy and 813 underwent minimally invasive surgical (n=467) or endoscopic (n=346) necrosectomy. There was a lower risk of death for minimally invasive surgical necrosectomy (OR, 0.53; 95% CI 0.34 to 0.84; p=0.006) and endoscopic necrosectomy (OR, 0.20; 95% CI 0.06 to 0.63; p=0.006). After propensity score matching with risk stratification, minimally invasive surgical necrosectomy remained associated with a lower risk of death than open necrosectomy in the very high-risk group (42/111 vs 59/111; risk ratio, 0.70; 95% CI 0.52 to 0.95; p=0.02). Endoscopic necrosectomy was associated with a lower risk of death than open necrosectomy in the high-risk group (3/40 vs 12/40; risk ratio, 0.27; 95% CI 0.08 to 0.88; p=0.03) and in the very high-risk group (12/57 vs 28/57; risk ratio, 0.43; 95% CI 0.24 to 0.77; p=0.005). CONCLUSION: In high-risk patients with necrotising pancreatitis, minimally invasive surgical and endoscopic necrosectomy are associated with reduced death rates compared with open

Published
2018

32. Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: A pooled analysis of individual data for 1980 patients

Author

Brunschot, S. (Sandra) van, Hollemans, R.A. (Robbert A), Bakker, O.J. (Olaf ), Besselink, M.G. (Marc), Baron, T.H. (Todd H), Berger, M.Y. (Marjolein), Boermeester, M.A. (Marja), Bollen, T.L. (Thomas), Bruno, M.J. (Marco), Carter, R. (Ross), French, J.J. (Jeremy J), Coelho, D. (Djalma), Dahl, B. (Björn), Dijkgraaf, M.G.W. (Marcel), Doctor, N. (Nilesh), Fagenholz, P.J. (Peter J), Farkas, G. (Gyula), Castillo, C.F.D. (Carlos Fernandez Del), Fockens, P. (Paul), Freeman, M.L. (Martin L), Gardner, T.B. (Timothy B), Goor, H. (Harry) van, Gooszen, H.G. (Hein), Hannink, G. (Gerjon), Lochan, R. (Rajiv), McKay, C. (Colin), Neoptolemos, J.P. (John), Oláh, A. (Atilla), Parks, R.W. (Rowan W), Peev, M.P. (Miroslav P), Raraty, M. (Michael), Rau, B. (Bettina), Rösch, T. (Thomas), Rovers, M.M. (Maroeska), Seifert, H. (Hans), Siriwardena, A.K. (Ajith K), Horvath, K.D. (Karen), Santvoort, H.C. (Hjalmar) van, Brunschot, S. (Sandra) van, Hollemans, R.A. (Robbert A), Bakker, O.J. (Olaf ), Besselink, M.G. (Marc), Baron, T.H. (Todd H), Berger, M.Y. (Marjolein), Boermeester, M.A. (Marja), Bollen, T.L. (Thomas), Bruno, M.J. (Marco), Carter, R. (Ross), French, J.J. (Jeremy J), Coelho, D. (Djalma), Dahl, B. (Björn), Dijkgraaf, M.G.W. (Marcel), Doctor, N. (Nilesh), Fagenholz, P.J. (Peter J), Farkas, G. (Gyula), Castillo, C.F.D. (Carlos Fernandez Del), Fockens, P. (Paul), Freeman, M.L. (Martin L), Gardner, T.B. (Timothy B), Goor, H. (Harry) van, Gooszen, H.G. (Hein), Hannink, G. (Gerjon), Lochan, R. (Rajiv), McKay, C. (Colin), Neoptolemos, J.P. (John), Oláh, A. (Atilla), Parks, R.W. (Rowan W), Peev, M.P. (Miroslav P), Raraty, M. (Michael), Rau, B. (Bettina), Rösch, T. (Thomas), Rovers, M.M. (Maroeska), Seifert, H. (Hans), Siriwardena, A.K. (Ajith K), Horvath, K.D. (Karen), and Santvoort, H.C. (Hjalmar) van

Abstract

Objective Minimally invasive surgical necrosectomy and endoscopic necrosectomy, compared with open necrosectomy, might improve outcomes in necrotising pancreatitis, especially in critically ill patients. Evidence from large comparative studies is lacking. Design We combined original and newly collected data from 15 published and unpublished patient cohorts (51 hospitals; 8 countries) on pancreatic necrosectomy for necrotising pancreatitis. Death rates were compared in patients undergoing open necrosectomy versus minimally invasive surgical or endoscopic necrosectomy. To adjust for confounding and to study effect modification by clinical severity, we performed two types of analyses: logistic multivariable regression and propensity score matching with stratification according to predicted risk of death at baseline (low: <5%; intermediate: ≥5% to <15%; high: ≥15% to <35%; and very high: ≥35%). Results Among 1980 patients with necrotising pancreatitis, 1167 underwent open necrosectomy and 813 underwent minimally invasive surgical (n=467) or endoscopic (n=346) necrosectomy. There was a lower risk of death for minimally invasive surgical necrosectomy (OR, 0.53; 95% CI 0.34 to 0.84; p=0.006) and endoscopic necrosectomy (OR, 0.20; 95% CI 0.06 to 0.63; p=0.006). After propensity score matching with risk stratification, minimally invasive surgical necrosectomy remained associated with a lower risk of death than open necrosectomy in the very high-risk group (42/111 vs 59/111; risk ratio, 0.70; 95% CI 0.52 to 0.95; p=0.02). Endoscopic necrosectomy was associated with a lower risk of death than open necrosectomy in the high-risk group (3/40 vs 12/40; risk ratio, 0.27; 95% CI 0.08 to 0.88; p=0.03) and in the very high-risk group (12/57 vs 28/57; risk ratio, 0.43; 95% CI 0.24 to 0.77; p=0.005). Conclusion In high-risk patients with necrotising pancreatitis, minimally invasive surgical and endoscopic necrosectomy are associated with reduced death rates compared with open necrosecto

Published
2018
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33. Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: a pooled analysis of individual data for 1980 patients

Author

van Brunschot, S, Hollemans, RA, Bakker, OJ, Besselink, MG, Baron, TH, Beger, HG, Boermeester, MA, Bollen, TL, Bruno, Marco, Carter, R, French, JJ, Coelho, D, Dahl, B, Dijkgraaf, MG, Doctor, N, Fagenholz, PJ, Farkas, G, del Castillo, CF, Fockens, P, Freeman, ML, Gardner, TB, van Goor, H, Gooszen, HG, Hannink, G, Lochan, R, McKay, CJ, Neoptolemos, JP, Olah, A, Parks, RW, Peev, MP, Raraty, M, Rau, B, Rosch, T, Rovers, M, Seifert, H, Siriwardena, AK, Horvath, KD, van Santvoort, HC, van Brunschot, S, Hollemans, RA, Bakker, OJ, Besselink, MG, Baron, TH, Beger, HG, Boermeester, MA, Bollen, TL, Bruno, Marco, Carter, R, French, JJ, Coelho, D, Dahl, B, Dijkgraaf, MG, Doctor, N, Fagenholz, PJ, Farkas, G, del Castillo, CF, Fockens, P, Freeman, ML, Gardner, TB, van Goor, H, Gooszen, HG, Hannink, G, Lochan, R, McKay, CJ, Neoptolemos, JP, Olah, A, Parks, RW, Peev, MP, Raraty, M, Rau, B, Rosch, T, Rovers, M, Seifert, H, Siriwardena, AK, Horvath, KD, and van Santvoort, HC

Published
2018

34. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

Author

Mukherjee, R., Mareninova, O. A., Odinokova, I. V., Huang, W., Murphy, J., Chvanov, M., Javed, M. A., Wen, L., Booth, D. M., Cane, M. C., Awais, M., Gavillet, B., Pruss, R. M., Schaller, S., Molkentin, J. D., Tepikin, A. V., Petersen, Ole Holger, Pandol, S. J., Gukovsky, I., Criddle, D. N., Gukovskaya, A. S., Sutton, R., Latawiec, D., Rajamanoharan, D., Mclaughlin, E., Ghaneh, P., Halloran, C., Neoptolemos, J. P., Raraty, M. G., French, S. W., and NIHR Pancreas Biomedical Research Unit

Subjects
QR
Abstract

Objective Acute pancreatitis is caused by toxins that induce acinar cell calcium overload, zymogen activation, cytokine release and cell death, yet is without specific drug therapy. Mitochondrial dysfunction has been implicated but the mechanism not established.\ud \ud Design We investigated the mechanism of induction and consequences of the mitochondrial permeability transition pore (MPTP) in the pancreas using cell biological methods including confocal microscopy, patch clamp technology and multiple clinically representative disease models. Effects of genetic and pharmacological inhibition of the MPTP were examined in isolated murine and human pancreatic acinar cells, and in hyperstimulation, bile acid, alcoholic and choline-deficient, ethionine-supplemented acute pancreatitis.\ud \ud Results MPTP opening was mediated by toxin-induced inositol trisphosphate and ryanodine receptor calcium channel release, and resulted in diminished ATP production, leading to impaired calcium clearance, defective autophagy, zymogen activation, cytokine production, phosphoglycerate mutase 5 activation and necrosis, which was prevented by intracellular ATP supplementation. When MPTP opening was inhibited genetically or pharmacologically, all biochemical, immunological and histopathological responses of acute pancreatitis in all four models were reduced or abolished.\ud \ud Conclusions This work demonstrates the mechanism and consequences of MPTP opening to be fundamental to multiple forms of acute pancreatitis and validates the MPTP as a drug target for this disease.

Published
2016

37. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Author

van Grinsven, J. (Janneke), Brunschot, S. (Sandra) van, Fockens, P. (Paul), Grinsven, J. (Janneke) van, Bakker, O.J. (Olaf ), van Santvoort, H.C. (Hjalmar C.), Bollen, T.L. (Thomas), Boermeester, M.A. (Marja), Eijck, C.H.J. (Casper) van, Besselink, M.G. (Marc), Bruno, M.J. (Marco), Dejong, C.H. (Cees), Horvath, K.D. (Karen), van Eijck, C.H. (Casper H.), Goor, H. (Harry) van, Gooszen, H.G. (Hein), Horvath, K.D. (Karen D.), Lienden, K.P. (Krijn) van, Abdelhafez, M., Andersson, R., Andren-Sandberg, A., Ashley, S., Baal, M.C. (Mark) van, Baron, T., Bassi, C. (Claudio), Bradley, E., Buchler, M.W. (M.), Cappendijk, V.C., Carter, R., Charnley, R., Coelho, D., Connor, S., Dellinger, P., Dervenis, C. (Christos), Devière, J. (J.), Doctor, N., Dudeja, V., En-qiang, M., Escourrou, J., Fagenholz, P., Farkas, G., Forsmark, C., Freeman, M., Freeny, P.C. (Patrick), French, J., Friess, H., Gardner, T., Goetzinger, P., Haveman, J.W., Hofker, S. (Sijbrand), Imrie, C., Isaji, S., Isenmann, R., Klar, E. (Ernst), Laméris, J.S. (Johan ), Lerch, M. (M.), Lévy, P. (Philippe), Lillemoe, K., Löhr, M., Mayerle, J. (Julia), Mayumi, T., Mittal, A., Moessner, J., Morgan, D., Mortele, K.J. (Koenraad), Nealon, W., Neoptolemos, J.P. (John), Nieuwenhuijs, V.B. (Vincent), Nordback, I., Olah, A., Oppong, K. (K.), Padbury, R., Papachristou, G., Parks, R., Poley, J.-W. (Jan-Werner), Radenkovic, D., Raraty, M., Rau, B., Rebours, V. (Vinciane), Rische, S., Runzi, M., Sainani, N., Sarr, M., Schaapherder, S., Seewald, S. (Stefan), Seifert, H., Shimosegawa, T., Silverman, S., Singh, V., Siriwardena, A., Steinberg, W., Sutton, R., Takeda, K., Timmer, R. (Robin), Vege, S., Voermans, R.P. (Rogier), De Waele, J.J. (Jan J.), Wang, C. (Ch.), Warshaw, A., Werner, J. (Jens Martin), Weusten, B.L. (Bas), Whitcomb, D., Wig, J., Windsor, J., Zyromski, N., van Grinsven, J. (Janneke), Brunschot, S. (Sandra) van, Fockens, P. (Paul), Grinsven, J. (Janneke) van, Bakker, O.J. (Olaf ), van Santvoort, H.C. (Hjalmar C.), Bollen, T.L. (Thomas), Boermeester, M.A. (Marja), Eijck, C.H.J. (Casper) van, Besselink, M.G. (Marc), Bruno, M.J. (Marco), Dejong, C.H. (Cees), Horvath, K.D. (Karen), van Eijck, C.H. (Casper H.), Goor, H. (Harry) van, Gooszen, H.G. (Hein), Horvath, K.D. (Karen D.), Lienden, K.P. (Krijn) van, Abdelhafez, M., Andersson, R., Andren-Sandberg, A., Ashley, S., Baal, M.C. (Mark) van, Baron, T., Bassi, C. (Claudio), Bradley, E., Buchler, M.W. (M.), Cappendijk, V.C., Carter, R., Charnley, R., Coelho, D., Connor, S., Dellinger, P., Dervenis, C. (Christos), Devière, J. (J.), Doctor, N., Dudeja, V., En-qiang, M., Escourrou, J., Fagenholz, P., Farkas, G., Forsmark, C., Freeman, M., Freeny, P.C. (Patrick), French, J., Friess, H., Gardner, T., Goetzinger, P., Haveman, J.W., Hofker, S. (Sijbrand), Imrie, C., Isaji, S., Isenmann, R., Klar, E. (Ernst), Laméris, J.S. (Johan ), Lerch, M. (M.), Lévy, P. (Philippe), Lillemoe, K., Löhr, M., Mayerle, J. (Julia), Mayumi, T., Mittal, A., Moessner, J., Morgan, D., Mortele, K.J. (Koenraad), Nealon, W., Neoptolemos, J.P. (John), Nieuwenhuijs, V.B. (Vincent), Nordback, I., Olah, A., Oppong, K. (K.), Padbury, R., Papachristou, G., Parks, R., Poley, J.-W. (Jan-Werner), Radenkovic, D., Raraty, M., Rau, B., Rebours, V. (Vinciane), Rische, S., Runzi, M., Sainani, N., Sarr, M., Schaapherder, S., Seewald, S. (Stefan), Seifert, H., Shimosegawa, T., Silverman, S., Singh, V., Siriwardena, A., Steinberg, W., Sutton, R., Takeda, K., Timmer, R. (Robin), Vege, S., Voermans, R.P. (Rogier), De Waele, J.J. (Jan J.), Wang, C. (Ch.), Warshaw, A., Werner, J. (Jens Martin), Weusten, B.L. (Bas), Whitcomb, D., Wig, J., Windsor, J., and Zyromski, N.

Abstract

Background The optimal diagnostic strategy and timing of intervention in infected necrotizing pancreatitis is subject to debate. We performed a survey on these topics amongst a group of international expert pancreatologists. Methods An online survey including case vignettes was sent to 118 international pancreatologists. We evaluated the use and timing of fine needle aspiration (FNA), antibiotics, catheter drainage and (minimally invasive) necrosectomy. Results The response rate was 74% (N = 87). None of the respondents use FNA routinely, 85% selectively and 15% never. Most respondents (87%) use a step-up approach in patients with infected necrosis. Walled-off necrosis (WON) is considered a prerequisite for endoscopic drainage and percutaneous drainage by 66% and 12%, respectively. After diagnosing infected necrosis, 55% routinely postpone invasive interventions, whereas 45% proceed immediately to intervention. Lack of consensus about timing of intervention was apparent on day 14 with proven infected necrosis (58% intervention vs. 42% non-invasive) as well as on day 20 with only clinically suspected infected necrosis (59% intervention vs. 41% non-invasive). Discussion The step-up approach is the preferred treatment strategy in infected necrotizing pancreatitis amongst expert pancreatologists. There is no uniformity regarding the use of FNA and timing of intervention in the first 2–3 weeks of infected necrotizing pancreatitis.

Published
2016
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40. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Author

van Grinsven, Janneke, primary, van Brunschot, Sandra, additional, Bakker, Olaf J., additional, Bollen, Thomas L., additional, Boermeester, Marja A., additional, Bruno, Marco J., additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel G., additional, van Eijck, Casper H., additional, Fockens, Paul, additional, van Goor, Harry, additional, Gooszen, Hein G., additional, Horvath, Karen D., additional, van Lienden, Krijn P., additional, van Santvoort, Hjalmar C., additional, Besselink, Marc G., additional, Abdelhafez, M., additional, Andersson, R., additional, Andren-Sandberg, A., additional, Ashley, S., additional, van Baal, M., additional, Baron, T., additional, Bassi, C., additional, Bradley, E., additional, Buchler, M., additional, Cappendijk, V., additional, Carter, R., additional, Charnley, R., additional, Coelho, D., additional, Connor, S., additional, Dellinger, P., additional, Dervenis, C., additional, Deviere, J., additional, Doctor, N., additional, Dudeja, V., additional, En-qiang, M., additional, Escourrou, J., additional, Fagenholz, P., additional, Farkas, G., additional, Forsmark, C., additional, Freeman, M., additional, Freeny, P., additional, French, J., additional, Friess, H., additional, Gardner, T., additional, Goetzinger, P., additional, Haveman, J., additional, Hofker, S., additional, Imrie, C., additional, Isaji, S., additional, Isenmann, R., additional, Klar, E., additional, Laméris, J., additional, Lerch, M., additional, Lévy, P., additional, Lillemoe, K., additional, Löhr, M., additional, Mayerle, J., additional, Mayumi, T., additional, Mittal, A., additional, Moessner, J., additional, Morgan, D., additional, Mortele, K., additional, Nealon, W., additional, Neoptolemos, J., additional, Nieuwenhuijs, V., additional, Nordback, I., additional, Olah, A., additional, Oppong, K., additional, Padbury, R., additional, Papachristou, G., additional, Parks, R., additional, Poley, J., additional, Radenkovic, D., additional, Raraty, M., additional, Rau, B., additional, Rebours, V., additional, Rische, S., additional, Runzi, M., additional, Sainani, N., additional, Sarr, M., additional, Schaapherder, S., additional, Seewald, S., additional, Seifert, H., additional, Shimosegawa, T., additional, Silverman, S., additional, Singh, V., additional, Siriwardena, A., additional, Steinberg, W., additional, Sutton, R., additional, Takeda, K., additional, Timmer, R., additional, Vege, S., additional, Voermans, R., additional, de Waele, J., additional, Wang, Ch., additional, Warshaw, A., additional, Werner, J., additional, Weusten, B., additional, Whitcomb, D., additional, Wig, J., additional, Windsor, J., additional, and Zyromski, N., additional

Published
2016
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42. Abstracts from the twenty-third meeting of the pancreatic society of Great Britain and Ireland at the Village Hotel, Leeds, UK

Author

Johnson, C D, Ammori, B J, Davides, D, Vezakis, A, Larvin, M, McMahon, K J, Powell, J J, Hill, G, Storey, S, Murchison, J, Fearon, K, Ross, J, Siriwardena, A K, Pearce, N W, Smithies, A M, Sargen, K, Demaine, A G, Kingsnorth, A N, Becker, K L, Kite, P, Barclay, G R, Snider, R H, Nylen, E S, White, J C, Martin, I G, McMahon, M J, Raraty, M G T, et al, and University of Zurich

Subjects
142-005 142-005
Published
1999

43. Variation in the staging of colorectal carcinomas: a survey of current practice

Author

Raraty, M. G. and Winstanley, J. H.

Subjects
Observer Variation, Consultants, England, Pathology, Surgical, Lymphatic Metastasis, Humans, Clinical Competence, Colorectal Neoplasms, Research Article, Neoplasm Staging
Abstract

Dukes' staging is the most common means of staging and grouping colorectal carcinomas and is also used to determine which patients will be offered adjuvant therapies or entered into clinical trials. This study was performed to assess the degree of variation in the staging of colorectal carcinomas in normal clinical practice. Seven consultant surgeons and two consultant pathologists returned questionnaires asking them to stage 14 carcinomas on the basis of their pathology reports alone. The results show agreement among all nine in only six out of the 14 cases. In two cases there was a close to 50:50 split in perceived stage. Between them, the nine consultants produced eight different sets of staging results. These results indicate difficulties in the application of Dukes' staging system for several possible reasons. There may be misinterpretation of the written report, misapplication of the staging system because of unfamiliarity or confusion between the various modifications of Dukes' system which have been published. A more precisely defined staging system based on a standard proforma may be more appropriate in modern clinical practice.

Published
1998

44. Pancreatic stents with diclofenac reduce the incidence of post ERCP pancreatitis in patients undergoing molecular screening of pancreatic juice for pancreatic cancer

Author

Nicholson, J.A., primary, Butler, J., additional, Harrison, S., additional, Greenhalf, W., additional, Sutton, R., additional, Halloran, C., additional, Raraty, M., additional, Ghaneh, P., additional, Sarkar, S., additional, Smart, H.L., additional, Evans, J.C., additional, Neoptolemos, J.P., additional, and Lombard, M., additional

Published
2013
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45. Detection of mutations in pancreatic juice collected from the duodenum by post secretin-aspiration is not reliable

Author

Nicholson, J.A., primary, Butler, J., additional, Johnstone, M., additional, Yan, L., additional, Evans, J.C., additional, Sarkar, S., additional, Smart, H.L., additional, Lombard, M., additional, Halloran, C., additional, Ghaneh, P., additional, Raraty, M., additional, Sutton, R., additional, Neoptolemos, J.P., additional, and Greenhalf, W., additional

Published
2013
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49. ZYMOGEN GRANULE EXOCYTOSIS IN RESPONSE TO DIRECT ACTIVATION OF CHOLECYSTOKININ RECEPTORS ON ISOLATED HUMAN PANCREATIC ACINAR CELLS

Author

Murphy, J. A., primary, Criddle, D. N., additional, Sherwood, M., additional, Chvanov, M., additional, Mclaughlin, E., additional, Gerasimenko, J. V., additional, Raraty, M. G. T., additional, Ghaneh, P., additional, Neoptolemos, J. P., additional, Gerasmenko, O. V., additional, Tepikin, A. V., additional, Green, G. M., additional, Reeve, J. R., additional, Petersen, O. H., additional, and Sutton, R., additional

Published
2007
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