205 results on '"Rash, Lachlan D."'
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2. Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
3. Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
4. The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation
5. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
6. Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis : Implications as an analgesic lead
7. Hi1a Improves Sensorimotor Deficit following Endothelin-1-Induced Stroke in Rats but Does Not Improve Functional Outcomes following Filament-Induced Stroke in Mice
8. Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction.
9. Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction
10. Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans
11. Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
12. Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1
13. Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future …
14. Preface
15. Modulation of Ion Channels by Cysteine-Rich Peptides
16. Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1
17. Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms
18. Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a.
19. Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider
20. Total Synthesis of the Spider-Venom Peptide Hi1a
21. Chapter 8. Therapeutic Applications of Spider-Venom Peptides
22. Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a
23. Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System
24. Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3
25. Sex differences in the pharmacological activity of venom from several Australian spiders
26. Venomics: a new paradigm for natural products-based drug discovery
27. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels
28. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
29. Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: The N-terminal region is more important than enzymatic activity
30. Acid-sensing (proton-gated) ion channels (ASICs) (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
31. ASIC3: First the Heartache, Now a Migraine!
32. Inhibition of voltage-gated Na+ currents in sensory neurones by the sea anemone toxin APETx2
33. De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina)
34. Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3
35. The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a
36. Inhibition of acid‐sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain
37. Acid-sensing (proton-gated) ion channels (ASICs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
38. Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels
39. The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues
40. Acid-sensing ion channel modulator, APETx2, has a more complex phamacological and therapeutic profile than previously reported
41. Pharmacology and biochemistry of spider venoms
42. Sex differences in the pharmacological activity of venom from the white-tailed spider ( Lampona cylindrata)
43. Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain
44. The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
45. NaV1.7 as a pain target – From gene to pharmacology
46. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant
47. Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury
48. PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a
49. Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels
50. The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.
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