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Your search keyword '"Raskova Kafkova, Leona"' showing total 12 results
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12 results on '"Raskova Kafkova, Leona"'

2. Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets

Author

Raskova Kafkova, Leona, Brokesova, Diana, Krupka, Michal, Stehlikova, Zuzana, Dvorak, Jiri, Coufal, Stepan, Fajstova, Alena, Srutkova, Dagmar, Stepanova, Katerina, Hermanova, Petra, Stepankova, Renata, Uberall, Ivo, Skarda, Jozef, Novak, Zdenek, Vannucci, Luca, Tlaskalova-Hogenova, Helena, Jiraskova Zakostelska, Zuzana, Sinkora, Marek, Mestecky, Jiri, and Raska, Milan

Published
2021
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5. The IgA1 immune complex–mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy

Author

Tamouza, Houda, Chemouny, Jonathan M., Raskova Kafkova, Leona, Berthelot, Laureline, Flamant, Martin, Demion, Marie, Mesnard, Laurent, Paubelle, Etienne, Walker, Francine, Julian, Bruce A., Tissandié, Emilie, Tiwari, Meetu K., Camara, Niels O.S., Vrtovsnik, François, Benhamou, Marc, Novak, Jan, Monteiro, Renato C., and Moura, Ivan C.

Published
2012
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9. Secretory IgA N-glycans contribute to the protection against E. coliO55 infection of germ-free piglets

Author

Raskova Kafkova, Leona, Brokesova, Diana, Krupka, Michal, Stehlikova, Zuzana, Dvorak, Jiri, Coufal, Stepan, Fajstova, Alena, Srutkova, Dagmar, Stepanova, Katerina, Hermanova, Petra, Stepankova, Renata, Uberall, Ivo, Skarda, Jozef, Novak, Zdenek, Vannucci, Luca, Tlaskalova-Hogenova, Helena, Jiraskova Zakostelska, Zuzana, Sinkora, Marek, Mestecky, Jiri, and Raska, Milan

Abstract

Mucosal surfaces are colonized by highly diverse commensal microbiota. Coating with secretory IgA (SIgA) promotes the survival of commensal bacteria while it inhibits the invasion by pathogens. Bacterial coating could be mediated by antigen-specific SIgA recognition, polyreactivity, and/or by the SIgA-associated glycans. In contrast to many in vitro studies, only a few reported the effect of SIgA glycans in vivo. Here, we used a germ-free antibody-free newborn piglets model to compare the protective effect of SIgA, SIgA with enzymatically removed N-glycans, Fab, and Fc containing the secretory component (Fc-SC) during oral necrotoxigenic E. coliO55 challenge. SIgA, Fab, and Fc-SC were protective, whereas removal of N-glycans from SIgA reduced SIgA-mediated protection as demonstrated by piglets' intestinal histology, clinical status, and survival. In vitro analyses indicated that deglycosylation of SIgA did not reduce agglutination of E. coliO55. These findings highlight the role of SIgA-associated N-glycans in protection. Further structural studies of SIgA-associated glycans would lead to the identification of those involved in the species-specific inhibition of attachment to corresponding epithelial cells.

Published
2021
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10. Ability to downregulate the level of cyclin-dependent kinase inhibitor p27Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway

Author

Raskova Kafkova, Leona, primary, Navrkalova, Veronika, additional, Jarosova, Marie, additional, Loja, Tomas, additional, Chovancova, Jana, additional, Kucerova, Jana, additional, Kriegova, Eva, additional, Prochazka, Vit, additional, Novak, Zdenek, additional, Simkova, Dana, additional, Pospisilova, Sarka, additional, and Divoky, Vladimir, additional

Published
2016
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12. Ability to downregulate the level of cyclin-dependent kinase inhibitor p27 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway.

Author

Raskova Kafkova, Leona, Navrkalova, Veronika, Jarosova, Marie, Loja, Tomas, Chovancova, Jana, Kucerova, Jana, Kriegova, Eva, Prochazka, Vit, Novak, Zdenek, Simkova, Dana, Pospisilova, Sarka, and Divoky, Vladimir

Subjects
*CHRONIC lymphocytic leukemia, *CYCLIN-dependent kinase inhibitors, *DOWNREGULATION, *DNA damage, *NUCLEOTIDE sequencing, *GENETIC mutation, *ALLELES, *B cells
Abstract

The article discusses a study on the ability to downregulate the level of cyclin-dependent kinase inhibitor p27Kip1 in patients with chronic lymphocytic leukemia (CLL) after they experienced DNA damage. The study used next-generation deep sequencing to investigate 18 patients with CLL for the presence of mutations on the residual ATM allele. It also examined a pool of mononuclear cells (MNC) or purified B lymphocytes in the patients.

Published
2017
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