1. Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour.
- Author
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Malaeb SN, Rassi AI, Haddad MC, Seoud MA, and Yunis KA
- Subjects
- Abnormalities, Drug-Induced diagnostic imaging, Adult, Bone and Bones diagnostic imaging, Female, Humans, Infant, Newborn, Magnesium Sulfate therapeutic use, Pregnancy, Radiography, Twins, Abnormalities, Drug-Induced etiology, Bone Density drug effects, Bone and Bones abnormalities, Magnesium Sulfate adverse effects, Tocolysis adverse effects
- Abstract
Prolonged maternal magnesium sulphate infusion therapy for tocolysis of premature labour may result in secondary fetal hypermagnesaemia, which has been associated with bony abnormalities in the newborn. We report on four infants, members of two twin pregnancies, who were exposed to prolonged fetal hypermagnesaemia. Three of the infants, all appropriate for gestational age, showed abnormal radiological findings consisting of abnormal mineralisation of long-bone metaphyses owing to fetal hypermagnesaemia. The fourth infant, who was growth retarded, had normal bones. Intrauterine growth restriction appears to be protective against magnesium sulphate-induced abnormal bone mineralisation in the newborn.
- Published
- 2004
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