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3. Outcomes of Cytoreductive Radical Prostatectomy for Oligometastatic Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography: Results of a Multicenter European Study

Author

Rajwa, Pawel, Robesti, Daniele, Chaloupka, Michael, Zattoni, Fabio, Giesen, Alexander, Huebner, Nicolai A., Krzywon, Aleksandra, Miszczyk, Marcin, Moll, Matthias, Stando, Rafał, Cisero, Edoardo, Semko, Sofiya, Checcucci, Enrico, Devos, Gaëtan, Apfelbeck, Maria, Gatti, Cecilia, Marra, Giancarlo, van den Bergh, Roderick C.N., Goldner, Gregor, Rasul, Sazan, Ceci, Francesco, Dal Moro, Fabrizio, Porpiglia, Francesco, Gontero, Paolo, Bjartell, Anders, Stief, Christian, Heidenreich, Axel, Joniau, Steven, Briganti, Alberto, Shariat, Shahrokh F., and Gandaglia, Giorgio

Published
2024
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4. Real-world Outcomes and Predictive Biomarkers for 177Lutetium Prostate-specific Membrane Antigen Ligand Treatment in Metastatic Castration-resistant Prostate Cancer: A European Association of Urology Young Academic Urologists Prostate Cancer Working Group Multi-institutional Observational Study

Author

Kafka, Mona, Horninger, Andreas, di Santo, Gianpaolo, Virgolini, Irene, Neuwirt, Hannes, Unterrainer, Lena M., Kunte, Sophie C., Deiss, Emil, Paffenholz, Pia, Heidenreich, Axel, Rasul, Sazan, Einspieler, Holger, Shariat, Shahrokh F., Rajwa, Pawel, Dozauer, Robert, Tsaur, Igor, Medlock, Ellen, Rölz, Niklas, Rausch, Steffen, la Fougère, Christian, Trautwein, Nils, Roesch, Marie C., Merseburger, Axel S., Zattoni, Fabio, Sepulcri, Matteo, Ladurner, Michael, Bektic, Jasmin, Gandaglia, Giorgio, Horninger, Wolfgang, and Heidegger, Isabel

Published
2024
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14. Diagnostic Performance of Prostate-specific Membrane Antigen Positron Emission Tomography–targeted biopsy for Detection of Clinically Significant Prostate Cancer: A Systematic Review and Meta-analysis

Author

Kawada, Tatsushi, Yanagisawa, Takafumi, Rajwa, Pawel, Sari Motlagh, Reza, Mostafaei, Hadi, Quhal, Fahad, Laukhtina, Ekaterina, Aydh, Abdulmajeed, König, Frederik, Pallauf, Maximilian, Pradere, Benjamin, Ceci, Francesco, Baltzer, Pascal A.T., Hacker, Marcus, Rasul, Sazan, Karakiewicz, Pierre I., Araki, Motoo, Nasu, Yasutomo, and Shariat, Shahrokh F.

Published
2022
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15. Feasibility and Optimal Time Point of [68Ga]Gallium-labeled Prostate-specific Membrane Antigen Ligand Positron Emission Tomography Imaging in Patients Undergoing Cytoreductive Surgery After Systemic Therapy for Primary Oligometastatic Prostate Cancer: Implications for Patient Selection and Extent of Surgery

Author

Huebner, Nicolai, Rasul, Sazan, Baltzer, Pascal, Clauser, Paola, Hermann Grubmüller, Karl, Mitterhauser, Markus, Hacker, Marcus, Heidenreich, Axel, Rajwa, Pawel, Fajkovic, Harun, Shariat, Shahrokh F., and Grubmüller, Bernhard

Published
2022
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17. Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1

Author

Rischka, Lucas, Murgaš, Matej, Pichler, Verena, Vraka, Chrysoula, Rausch, Ivo, Winkler, Dietmar, Nics, Lukas, Rasul, Sazan, Silberbauer, Leo Robert, Reed, Murray Bruce, Godbersen, Godber Mathis, Unterholzner, Jakob, Handschuh, Patricia, Gryglewski, Gregor, Mindt, Thomas, Mitterhauser, Markus, Hahn, Andreas, Ametamey, Simon Mensah, Wadsak, Wolfgang, Lanzenberger, Rupert, and Hacker, Marcus

Published
2022
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19. Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations

Author

Einspieler, Holger, primary, Kluge, Kilian, additional, Haberl, David, additional, Schatz, Katrin, additional, Nics, Lukas, additional, Schmitl, Stefan, additional, Geist, Barbara Katharina, additional, Spielvogel, Clemens P., additional, Grubmüller, Bernhard, additional, Baltzer, Pascal A. T., additional, Kramer, Gero, additional, Shariat, Shahrokh F., additional, Hacker, Marcus, additional, and Rasul, Sazan, additional

Published
2024
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24. A novel assessment of whole-mount Gleason grading in prostate cancer to identify candidates for radical prostatectomy: a machine learning-based multiomics study.

Author

Ning, Jing, Spielvogel, Clemens P., Haberl, David, Trachtova, Karolina, Stoiber, Stefan, Rasul, Sazan, Bystry, Vojtech, Wasinger, Gabriel, Baltzer, Pascal, Gurnhofer, Elisabeth, Timelthaler, Gerald, Schlederer, Michaela, Papp, Laszlo, Schachner, Helga, Helbich, Thomas, Hartenbach, Markus, Grubmüller, Bernhard, Shariat, Shahrokh F, Hacker, Marcus, and Haug, Alexander

Published
2024
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27. In vivo assessment of safety, biodistribution, and radiation dosimetry of the [18F]Me4FDG PET-radiotracer in adults.

Author

Geist, Barbara Katharina, Ramirez, Juan Carlos, Binder, Patrick, Einspieler, Holger, Ibeschitz, Harald, Langsteger, Werner, Nics, Lukas, Rausch, Ivo, Diemling, Markus, Sohlberg, Antti, Hacker, Marcus, and Rasul, Sazan

Subjects
RADIATION dosimetry, RADIOACTIVE tracers, POSITRON emission tomography, COMPUTED tomography, GLUCOSE transporters, ADULTS
Abstract

Background: Approaches targeting the sodium-glucose cotransporter (SGLT) could represent a promising future therapeutic strategy for numerous oncological and metabolic diseases. In this study, we evaluated the safety, biodistribution and radiation dosimetry of the glucose analogue positron emission tomography (PET) agent [18F] labeled alpha-methyl-4-deoxy-4-[18F]fluoro-D-glucopyranoside ([18F]Me4FDG) with high sodium-glucose cotransporter and low glucose transporter (GLUT) affinity. For this purpose, five healthy volunteers (1 man, 4 women) underwent multiple whole-body PET/computed tomography (CT) examinations starting with injection and up to 4 h after injection of averaged (2.4 ± 0.1) MBq/kg (range: 2.3–2.5 MBq/kg) administered activity. The PET/CT scans were conducted in 5 separate sessions, blood pressure and temperature were measured, and blood and urine samples were collected before the scans and one hour after injection to assess toxicity. Measurements of [18F]Me4FDG radioactivity in organs of interest were determined from the PET/CT scans at 5 time points. Internal dosimetry was performed on voxel level using a fast Monte Carlo approach. Results: All studied volunteers could well tolerate the [18F]Me4FDG and no adverse event was reported. The calculated effective dose was (0.013 ± 0.003) mSv/MBq. The organs with the highest absorbed dose were the kidneys with 0.05 mSv/MBq per kidney. The brain showed almost no uptake. After 60 min, (12 ± 15) % of the administered dose was excreted into the bladder. Conclusion: Featuring an effective dose of only 0.013 ± 0.003 mSv/MBq and no occurrence of side effects, the glucose analogue [18F]Me4FDG seems to be a safe radio-tracer with a favorable biodistribution for PET imaging and also within several consecutive scans. Trial registration number: NCT03557138, Registered 22 February 2017, https://ichgcp.net/clinical-trials-registry/NCT03557138. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [ 68 Ga]Ga-PSMA-11-PET Examinations.

Author

Einspieler, Holger, Kluge, Kilian, Haberl, David, Schatz, Katrin, Nics, Lukas, Schmitl, Stefan, Geist, Barbara Katharina, Spielvogel, Clemens P., Grubmüller, Bernhard, Baltzer, Pascal A. T., Kramer, Gero, Shariat, Shahrokh F., Hacker, Marcus, and Rasul, Sazan

Subjects
RADIOISOTOPE therapy, CASTRATION-resistant prostate cancer, PROSTATE-specific antigen, CANCER relapse, T-test (Statistics), PROSTATE tumors, POSITRON emission tomography, MANN Whitney U Test, DESCRIPTIVE statistics, GENE expression, METASTASIS
Abstract

Simple Summary: Radioligand therapies targeting prostate-specific membrane antigen (PSMA) receptors are currently being investigated in several ongoing trials for their application in early stages of prostate cancer (PCa). The aim of this study is to identify the PSMA-ligand binding in patients with early and advanced stages of PCa by measuring changes in the PSMA uptake in various organs, including non-physiologically PSMA-expressing organs, as differences in PSMA expression could lead to unpredictable radiotoxicity in early-stage PCa patients. In addition, total tumor volume (TTV) was determined to evaluate differences in PSMA-ligand uptake related to TTV in the investigated cohorts. The efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is currently being investigated for its application in patients with early-stage prostate cancer (PCa). However, little is known about PSMA expression in healthy organs in this cohort. Collectively, 202 [68Ga]Ga-PSMA-11 positron emission tomography (PET) scans from 152 patients were studied. Of these, 102 PET scans were from patients with primary PCa and hormone-sensitive biochemically recurrent PCa and 50 PET scans were from patients with metastatic castration-resistant PCa (mCRPC) before and after three cycles of [177Lu]Lu-PSMA-RLT. PSMA-standardized uptake values (SUV) were measured in multiple organs and PSMA-total tumor volume (PSMA-TTV) was determined in all cohorts. The measured PET parameters of the different cohorts were normalized to the bloodpool and compared using t- or Mann–Whitney U tests. Patients with early-stage PCa had lower PSMA-TTVs (10.39 mL vs. 462.42 mL, p < 0.001) and showed different SUVs in the thyroid, submandibular glands, heart, liver, kidneys, intestine, testes and bone marrow compared to patients with advanced CRPC, with all tests showing p < 0.05. Despite the differences in the PSMA-TTV of patients with mCRPC before and after [177Lu]Lu-PSMA-RLT (462.42 mL vs. 276.29 mL, p = 0.023), no significant organ differences in PET parameters were detected. These suggest different degrees of PSMA-ligand binding among patients with different stages of PCa that could influence radiotoxicity during earlier stages of disease in different organs when PSMA-RLT is administered. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Outcomes of Cytoreductive Radical Prostatectomy for Oligometastatic Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography: Results of a Multicenter European Study

Author

Rajwa, Pawel, primary, Robesti, Daniele, additional, Chaloupka, Michael, additional, Zattoni, Fabio, additional, Giesen, Alexander, additional, Huebner, Nicolai A., additional, Krzywon, Aleksandra, additional, Miszczyk, Marcin, additional, Moll, Matthias, additional, Stando, Rafał, additional, Cisero, Edoardo, additional, Semko, Sofiya, additional, Checcucci, Enrico, additional, Devos, Gaëtan, additional, Apfelbeck, Maria, additional, Gatti, Cecilia, additional, Marra, Giancarlo, additional, van den Bergh, Roderick C.N., additional, Goldner, Gregor, additional, Rasul, Sazan, additional, Ceci, Francesco, additional, Dal Moro, Fabrizio, additional, Porpiglia, Francesco, additional, Gontero, Paolo, additional, Bjartell, Anders, additional, Stief, Christian, additional, Heidenreich, Axel, additional, Joniau, Steven, additional, Briganti, Alberto, additional, Shariat, Shahrokh F., additional, and Gandaglia, Giorgio, additional

Published
2023
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32. Direct Patlak Reconstruction of [68Ga]Ga-PSMA PET for the Evaluation of Primary Prostate Cancer Prior Total Prostatectomy: Results of a Pilot Study

Author

Rasul, Sazan, primary, Geist, Barbara Katharina, additional, Einspieler, Holger, additional, Fajkovic, Harun, additional, Shariat, Shahrokh F., additional, Schmitl, Stefan, additional, Mitterhauser, Markus, additional, Bartosch, Rainer, additional, Langsteger, Werner, additional, Baltzer, Pascal Andreas Thomas, additional, Beyer, Thomas, additional, Ferrara, Daria, additional, Haug, Alexander R., additional, Hacker, Marcus, additional, and Rausch, Ivo, additional

Published
2023
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33. Real-world Outcomes and Predictive Biomarkers for 177Lutetium Prostate-specific Membrane Antigen Ligand Treatment in Metastatic Castration-resistant Prostate Cancer: A European Association of Urology Young Academic Urologists Prostate Cancer Working Group Multi-institutional Observational Study

Author

Kafka, Mona, primary, Horninger, Andreas, additional, di Santo, Gianpaolo, additional, Virgolini, Irene, additional, Neuwirt, Hannes, additional, Unterrainer, Lena M., additional, Kunte, Sophie C., additional, Deiss, Emil, additional, Paffenholz, Pia, additional, Heidenreich, Axel, additional, Rasul, Sazan, additional, Einspieler, Holger, additional, Shariat, Shahrokh F., additional, Rajwa, Pawel, additional, Dozauer, Robert, additional, Tsaur, Igor, additional, Medlock, Ellen, additional, Rölz, Niklas, additional, Rausch, Steffen, additional, la Fougère, Christian, additional, Trautwein, Nils, additional, Roesch, Marie C., additional, Merseburger, Axel S., additional, Zattoni, Fabio, additional, Sepulcri, Matteo, additional, Ladurner, Michael, additional, Bektic, Jasmin, additional, Gandaglia, Giorgio, additional, Horninger, Wolfgang, additional, and Heidegger, Isabel, additional

Published
2023
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37. Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM)

Author

Nensa, Felix, Bamberg, Fabian, Rischpler, Christoph, Menezes, Leon, Poeppel, Thorsten D., la Fougère, Christian, Beitzke, Dietrich, Rasul, Sazan, Loewe, Christian, Nikolaou, Konstantin, Bucerius, Jan, Kjaer, Andreas, Gutberlet, Matthias, Prakken, Niek H., Vliegenthart, Rozemarijn, Slart, Riemer H. J. A., Nekolla, Stephan G., Lassen, Martin L., Pichler, Bernd J., Schlosser, Thomas, Jacquier, Alexis, Quick, Harald H., Schäfers, Michael, Hacker, Marcus, on behalf of the European Society of Cardiovascular Radiology (ESCR), and the European Association of Nuclear Medicine (EANM) Cardiovascular Committee

Published
2018
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39. A Prognostic Risk Score for Prostate Cancer Based on PSMA PET–derived Organ-specific Tumor Volumes

Author

Seifert, Robert, primary, Rasul, Sazan, additional, Seitzer, Konstantin, additional, Eveslage, Maria, additional, Rahbar Nikoukar, Laya, additional, Kessel, Katharina, additional, Schäfers, Michael, additional, Yu, Josef, additional, Haug, Alexander R., additional, Hacker, Marcus, additional, Bögemann, Martin, additional, Bodei, Lisa, additional, Morris, Michael J., additional, Hofman, Michael S., additional, and Rahbar, Kambiz, additional

Published
2023
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43. Direct Patlak Reconstruction of [ 68 Ga]Ga-PSMA PET for the Evaluation of Primary Prostate Cancer Prior Total Prostatectomy: Results of a Pilot Study.

Author

Rasul, Sazan, Geist, Barbara Katharina, Einspieler, Holger, Fajkovic, Harun, Shariat, Shahrokh F., Schmitl, Stefan, Mitterhauser, Markus, Bartosch, Rainer, Langsteger, Werner, Baltzer, Pascal Andreas Thomas, Beyer, Thomas, Ferrara, Daria, Haug, Alexander R., Hacker, Marcus, and Rausch, Ivo

Subjects
*ENDORECTAL ultrasonography, *POSITRON emission tomography, *PROSTATE, *PROSTATE cancer, *PROSTATECTOMY, *PROSTATE cancer patients, *RADICAL prostatectomy
Abstract

To investigate the use of kinetic parameters derived from direct Patlak reconstructions of [68Ga]Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) to predict the histological grade of malignancy of the primary tumor of patients with prostate cancer (PCa). Thirteen patients (mean age 66 ± 10 years) with a primary, therapy-naïve PCa (median PSA 9.3 [range: 6.3–130 µg/L]) prior radical prostatectomy, were recruited in this exploratory prospective study. A dynamic whole-body [68Ga]Ga-PSMA-11 PET/CT scan was performed for all patients. Measured quantification parameters included Patlak slope (Ki: absolute rate of tracer consumption) and Patlak intercept (Vb: degree of tracer perfusion in the tumor). Additionally, the mean and maximum standardized uptake values (SUVmean and SUVmax) of the tumor were determined from a static PET 60 min post tracer injection. In every patient, initial PSA (iPSA) values that were also the PSA level at the time of the examination and final histology results with Gleason score (GS) grading were correlated with the quantitative readouts. Collectively, 20 individual malignant prostate lesions were ascertained and histologically graded for GS with ISUP classification. Six lesions were classified as ISUP 5, two as ISUP 4, eight as ISUP 3, and four as ISUP 2. In both static and dynamic PET/CT imaging, the prostate lesions could be visually distinguished from the background. The average values of the SUVmean, slope, and intercept of the background were 2.4 (±0.4), 0.015 1/min (±0.006), and 52% (±12), respectively. These were significantly lower than the corresponding parameters extracted from the prostate lesions (all p < 0.01). No significant differences were found between these values and the various GS and ISUP (all p > 0.05). Spearman correlation coefficient analysis demonstrated a strong correlation between static and dynamic PET/CT parameters (all r ≥ 0.70, p < 0.01). Both GS and ISUP grading revealed only weak correlations with the mean and maximum SUV and tumor-to-background ratio derived from static images and dynamic Patlak slope. The iPSA demonstrated no significant correlation with GS and ISUP grading or with dynamic and static PET parameter values. In this cohort of mainly high-risk PCa, no significant correlation between [68Ga]Ga-PSMA-11 perfusion and consumption and the aggressiveness of the primary tumor was observed. This suggests that the association between SUV values and GS may be more distinctive when distinguishing clinically relevant from clinically non-relevant PCa. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Sex-specific radiomic features of L-[S-methyl-11C] methionine PET in patients with newly-diagnosed gliomas in relation to IDH1 predictability

Author

Papp, Laszlo, primary, Rasul, Sazan, additional, Spielvogel, Clemens P., additional, Krajnc, Denis, additional, Poetsch, Nina, additional, Woehrer, Adelheid, additional, Patronas, Eva-Maria, additional, Ecsedi, Boglarka, additional, Furtner, Julia, additional, Mitterhauser, Markus, additional, Rausch, Ivo, additional, Widhalm, Georg, additional, Beyer, Thomas, additional, Hacker, Marcus, additional, and Traub-Weidinger, Tatjana, additional

Published
2023
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45. Dual-Tracer PET-MRI-Derived Imaging Biomarkers for Prediction of Clinically Significant Prostate Cancer

Author

Grubmüller, Bernhard, primary, Huebner, Nicolai A., additional, Rasul, Sazan, additional, Clauser, Paola, additional, Pötsch, Nina, additional, Grubmüller, Karl Hermann, additional, Hacker, Marcus, additional, Hartenbach, Sabrina, additional, Shariat, Shahrokh F., additional, Hartenbach, Markus, additional, and Baltzer, Pascal, additional

Published
2023
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46. Consecutive Prostate-Specific Membrane Antigen (PSMA) and Antigen Receptor (AR) PET Imaging Shows Positive Correlation with AR and PSMA Protein Expression in Primary Hormone-Naïve Prostate Cancer

Author

al Jalali, Valentin, primary, Wasinger, Gabriel, additional, Rasul, Sazan, additional, Grubmüller, Bernhard, additional, Wulkersdorfer, Beatrix, additional, Balber, Theresa, additional, Mitterhauser, Markus, additional, Simon, Judit, additional, Hacker, Marcus, additional, Shariat, Shahrokh, additional, Egger, Gerda, additional, and Zeitlinger, Markus, additional

Published
2023
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49. Machine Learning Predictive Performance Evaluation of Conventional and Fuzzy Radiomics in Clinical Cancer Imaging Cohorts

Author

Grahovac, Marko, primary, Spielvogel, Clemens, additional, Krajnc, Denis, additional, Ecsedi, Boglarka, additional, Traub-Weidinger, Tatjana, additional, Rasul, Sazan, additional, Kluge, Kilian, additional, Zhao, Meixin, additional, Li, Xiang, additional, Hacker, Marcus, additional, Haug, Alexander, additional, and Papp, Laszlo, additional

Published
2022
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50. Automated data preparation for in vivo tumor characterization with machine learning

Author

Krajnc, Denis, primary, Spielvogel, Clemens P., additional, Grahovac, Marko, additional, Ecsedi, Boglarka, additional, Rasul, Sazan, additional, Poetsch, Nina, additional, Traub-Weidinger, Tatjana, additional, Haug, Alexander R., additional, Ritter, Zsombor, additional, Alizadeh, Hussain, additional, Hacker, Marcus, additional, Beyer, Thomas, additional, and Papp, Laszlo, additional

Published
2022
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