1,301 results on '"Ratnayaka A"'
Search Results
2. Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism
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Sanchez-Bretano, Aida, Keeling, Eloise, Scott, Jennifer A., Lynn, Savannah A., Soundara-Pandi, Sudha Priya, Macdonald, Sarah L., Newall, Tutte, Griffiths, Helen, Lotery, Andrew J., Ratnayaka, J. Arjuna, Self, Jay E., and Lee, Helena
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- 2023
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3. Interventional cardiovascular magnetic resonance: state-of-the-art
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Rogers, Toby, Campbell-Washburn, Adrienne E., Ramasawmy, Rajiv, Yildirim, D. Korel, Bruce, Christopher G., Grant, Laurie P., Stine, Annette M., Kolandaivelu, Aravindan, Herzka, Daniel A., Ratnayaka, Kanishka, and Lederman, Robert J.
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- 2023
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4. A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy
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Khan, Adnan H., Soundara Pandi, Sudha Priya, Scott, Jennifer A., Sánchez-Bretaño, Aida, Lynn, Savannah A., Ratnayaka, J. Arjuna, Teeling, Jessica L., and Lotery, Andrew J.
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- 2023
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5. MRI-Guided Cardiac Catheterization in Congenital Heart Disease: How to Get Started
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Amin, Elena K, Campbell-Washburn, Adrienne, and Ratnayaka, Kanishka
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease ,Biomedical Imaging ,Cardiovascular ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Cardiac Catheterization ,Heart ,Heart Defects ,Congenital ,Humans ,Magnetic Resonance Imaging ,Magnetic Resonance Imaging ,Interventional ,Interventional cardiac magnetic resonance ,Magnetic resonance imaging ,Cardiac catheterization ,Congenital heart disease ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Purpose of reviewCardiac magnetic resonance imaging provides radiation-free, 3-dimensional soft tissue visualization with adjunct hemodynamic data, making it a promising candidate for image-guided transcatheter interventions. This review focuses on the benefits and background of real-time magnetic resonance imaging (MRI)-guided cardiac catheterization, guidance on starting a clinical program, and recent research developments.Recent findingsInterventional cardiac magnetic resonance (iCMR) has an established track record with the first entirely MRI-guided cardiac catheterization for congenital heart disease reported nearly 20 years ago. Since then, many centers have embarked upon clinical iCMR programs primarily performing diagnostic MRI-guided cardiac catheterization. There have also been limited reports of successful real-time MRI-guided transcatheter interventions. Growing experience in performing cardiac catheterization in the magnetic resonance environment has facilitated practical workflows appropriate for efficiency-focused cardiac catheterization laboratories. Most exciting developments in imaging technology, MRI-compatible equipment and MRI-guided novel transcatheter interventions have been limited to preclinical research. Many of these research developments are ready for clinical translation. With increasing iCMR clinical experience and translation of preclinical research innovations, the time to make the leap to radiation-free procedures is now.
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- 2022
6. Selective Valve Removal for Melody Valve Endocarditis: Practice Variations in a Multicenter Experience
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Davtyan, Arpine, Guyon, Peter W, El-Sabrout, Hannah R, Ponder, Reid, Ramchandar, Nanda, Weber, Rachel, Zayed, Wagih, Ratnayaka, Kanishka, Nigro, John J, Moore, John W, Bauser-Heaton, Holly, Alshawabkeh, Laith, Reeves, Ryan R, Levi, Daniel, Aboulhosn, Jamil, Justino, Henri, Bradley, John, and El-Said, Howaida G
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Heart Disease ,Cardiovascular ,Clinical Research ,Infectious Diseases ,Cardiac Catheterization ,Endocarditis ,Endocarditis ,Bacterial ,Heart Valve Prosthesis ,Heart Valve Prosthesis Implantation ,Humans ,Prosthesis Design ,Pulmonary Valve ,Pulmonary Valve Insufficiency ,Retrospective Studies ,Treatment Outcome ,Congenital heart disease ,Transcatheter pulmonary valve ,Melody valve ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
Guidelines for management of Melody transcatheter pulmonary valve (TPV) infective endocarditis (IE) are lacking. We aimed to identify factors associated with surgical valve removal versus antimicrobial therapy in Melody TPV IE. Multicenter retrospective analysis of all patients receiving Melody TPV from 10/2010 to 3/2019 was performed to identify cases of IE. Surgical explants versus non-surgical cases were compared. Of the 663 Melody TPV implants, there were 66 cases of IE in 59 patients (59/663, 8.8%). 39/66 (59%) were treated with IV antimicrobials and 27/66(41%) underwent valve explantation. 26/59 patients (44%) were treated medically without explantation or recurrence with average follow-up time of 3.5 years (range:1-9). 32% of Streptococcus cases, 53% of MSSA, and all MRSA cases were explanted. 2 of the 4 deaths had MSSA. CART analysis demonstrated two important parameters associated with explantation: a peak echo gradient ≥ 47 mmHg at IE diagnosis(OR 10.6, p 24 mmHg compared to baseline (OR 6.7, p = 0.01). Rates of explantation varied by institution (27 to 64%). In our multicenter experience, 44% of patients with Melody IE were successfully medically treated without valve explantation or recurrence. The degree of valve stenosis at time of IE diagnosis was strongly associated with explantation. Rates of explantation varied significantly among the institutions.
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- 2022
7. Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism
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Aida Sanchez-Bretano, Eloise Keeling, Jennifer A. Scott, Savannah A. Lynn, Sudha Priya Soundara-Pandi, Sarah L. Macdonald, Tutte Newall, Helen Griffiths, Andrew J. Lotery, J. Arjuna Ratnayaka, Jay E. Self, and Helena Lee
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Medicine ,Science - Abstract
Abstract l-DOPA is deficient in the developing albino eye, resulting in abnormalities of retinal development and visual impairment. Ongoing retinal development after birth has also been demonstrated in the developing albino eye offering a potential therapeutic window in humans. To study whether human equivalent doses of l-DOPA/Carbidopa administered during the crucial postnatal period of neuroplasticity can rescue visual function, OCA C57BL/6 J-c2J OCA1 mice were treated with a 28-day course of oral l-DOPA/Carbidopa at 3 different doses from 15 to 43 days postnatal age (PNA) and for 3 different lengths of treatment, to identify optimum dosage and treatment length. Visual electrophysiology, acuity, and retinal morphology were measured at 4, 5, 6, 12 and 16 weeks PNA and compared to untreated C57BL/6 J (WT) and OCA1 mice. Quantification of PEDF, βIII-tubulin and syntaxin-3 expression was also performed. Our data showed impaired retinal morphology, decreased retinal function and lower visual acuity in untreated OCA1 mice compared to WT mice. These changes were diminished or eliminated when treated with higher doses of l-DOPA/Carbidopa. Our results demonstrate that oral l-DOPA/Carbidopa supplementation at human equivalent doses during the postnatal critical period of retinal neuroplasticity can rescue visual retinal morphology and retinal function, via PEDF upregulation and modulation of retinal synaptogenesis, providing a further step towards developing an effective treatment for albinism patients.
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- 2023
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8. Interventional cardiovascular magnetic resonance: state-of-the-art
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Toby Rogers, Adrienne E. Campbell-Washburn, Rajiv Ramasawmy, D. Korel Yildirim, Christopher G. Bruce, Laurie P. Grant, Annette M. Stine, Aravindan Kolandaivelu, Daniel A. Herzka, Kanishka Ratnayaka, and Robert J. Lederman
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Interventional cardiovascular magnetic resonance ,iCMR ,Magnetic resonance imaging ,Invasive cardiovascular magnetic resonance ,Cardiac catheterization ,Electrophysiology ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Transcatheter cardiovascular interventions increasingly rely on advanced imaging. X-ray fluoroscopy provides excellent visualization of catheters and devices, but poor visualization of anatomy. In contrast, magnetic resonance imaging (MRI) provides excellent visualization of anatomy and can generate real-time imaging with frame rates similar to X-ray fluoroscopy. Realization of MRI as a primary imaging modality for cardiovascular interventions has been slow, largely because existing guidewires, catheters and other devices create imaging artifacts and can heat dangerously. Nonetheless, numerous clinical centers have started interventional cardiovascular magnetic resonance (iCMR) programs for invasive hemodynamic studies or electrophysiology procedures to leverage the clear advantages of MRI tissue characterization, to quantify cardiac chamber function and flow, and to avoid ionizing radiation exposure. Clinical implementation of more complex cardiovascular interventions has been challenging because catheters and other tools require re-engineering for safety and conspicuity in the iCMR environment. However, recent innovations in scanner and interventional device technology, in particular availability of high performance low-field MRI scanners could be the inflection point, enabling a new generation of iCMR procedures. In this review we review these technical considerations, summarize contemporary clinical iCMR experience, and consider potential future applications.
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- 2023
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9. SigmaLaw-ABSA: Dataset for Aspect-Based Sentiment Analysis in Legal Opinion Texts
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Mudalige, Chanika Ruchini, Karunarathna, Dilini, Rajapaksha, Isanka, de Silva, Nisansa, Ratnayaka, Gathika, Perera, Amal Shehan, and Pathirana, Ramesh
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Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
Aspect-Based Sentiment Analysis (ABSA) has been prominent and ongoing research over many different domains, but it is not widely discussed in the legal domain. A number of publicly available datasets for a wide range of domains usually fulfill the needs of researchers to perform their studies in the field of ABSA. To the best of our knowledge, there is no publicly available dataset for the Aspect (Party) Based Sentiment Analysis for legal opinion texts. Therefore, creating a publicly available dataset for the research of ABSA for the legal domain can be considered as a task with significant importance. In this study, we introduce a manually annotated legal opinion text dataset (SigmaLaw-ABSA) intended towards facilitating researchers for ABSA tasks in the legal domain. SigmaLaw-ABSA consists of legal opinion texts in the English language which have been annotated by human judges. This study discusses the sub-tasks of ABSA relevant to the legal domain and how to use the dataset to perform them. This paper also describes the statistics of the dataset and as a baseline, we present some results on the performance of some existing deep learning based systems on the SigmaLaw-ABSA dataset., Comment: 6 pages, 2 figures, IEEE International Conference on Industrial and Information Systems(ICIIS) 2020
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- 2020
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10. Rule-Based Approach for Party-Based Sentiment Analysis in Legal Opinion Texts
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Rajapaksha, Isanka, Mudalige, Chanika Ruchini, Karunarathna, Dilini, de Silva, Nisansa, Ratnayaka, Gathika, and Perera, Amal Shehan
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Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
A document which elaborates opinions and arguments related to the previous court cases is known as a legal opinion text. Lawyers and legal officials have to spend considerable effort and time to obtain the required information manually from those documents when dealing with new legal cases. Hence, it provides much convenience to those individuals if there is a way to automate the process of extracting information from legal opinion texts. Party-based sentiment analysis will play a key role in the automation system by identifying opinion values with respect to each legal parties in legal texts., Comment: 2 pages, 1 figure, The 20th International Conference on Advances in ICT for Emerging Regions (ICTer2020)
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- 2020
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11. Contrastive learning for supervised graph matching.
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Gathika Ratnayaka, Qing Wang 0002, and Yang Li
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- 2023
12. Effective Approach to Develop a Sentiment Annotator For Legal Domain in a Low Resource Setting
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Ratnayaka, Gathika, de Silva, Nisansa, Perera, Amal Shehan, and Pathirana, Ramesh
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Computer Science - Computation and Language - Abstract
Analyzing the sentiments of legal opinions available in Legal Opinion Texts can facilitate several use cases such as legal judgement prediction, contradictory statements identification and party-based sentiment analysis. However, the task of developing a legal domain specific sentiment annotator is challenging due to resource constraints such as lack of domain specific labelled data and domain expertise. In this study, we propose novel techniques that can be used to develop a sentiment annotator for the legal domain while minimizing the need for manual annotations of data.
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- 2020
13. Enhancing the Identification of Cyberbullying through Participant Roles
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Ratnayaka, Gathika, Atapattu, Thushari, Herath, Mahen, Zhang, Georgia, and Falkner, Katrina
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Computer Science - Computation and Language - Abstract
Cyberbullying is a prevalent social problem that inflicts detrimental consequences to the health and safety of victims such as psychological distress, anti-social behaviour, and suicide. The automation of cyberbullying detection is a recent but widely researched problem, with current research having a strong focus on a binary classification of bullying versus non-bullying. This paper proposes a novel approach to enhancing cyberbullying detection through role modeling. We utilise a dataset from ASKfm to perform multi-class classification to detect participant roles (e.g. victim, harasser). Our preliminary results demonstrate promising performance including 0.83 and 0.76 of F1-score for cyberbullying and role classification respectively, outperforming baselines.
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- 2020
14. A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications [version 2; peer review: 3 approved, 1 approved with reservations]
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Philip J. Basford, Orestis L. Katsamenis, Richard P. Boardman, Stephanie K. Robinson, Peter M. Lackie, Elena Konstantinopoulou, J. Arjuna Ratnayaka, Anton Page, Gareth J. Thomas, Patricia M. Goggin, Ian Sinclair, Simon J. Cox, and Philipp Schneider
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3D X-ray Histology ,XRH ,Histology ,microCT ,μCT ,μ-CT ,eng ,Medicine ,Science - Abstract
Background The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray microfocus computed tomography (μCT) -based technology. This article presents the outcomes of these endeavours and highlights the distinctive characteristics of a μCT facility tailored explicitly for 3D X-ray Histology, with a primary focus on applications in biomedical research and preclinical and clinical studies. Methods The UHS houses a unique 3D X-ray Histology (XRH) facility, offering a range of services to national and international clients. The facility employs specialised μCT equipment explicitly designed for histology applications, allowing whole-block XRH imaging of formalin-fixed and paraffin-embedded tissue specimens. It also enables correlative imaging by combining μCT imaging with other microscopy techniques, such as immunohistochemistry (IHC) and serial block-face scanning electron microscopy, as well as data visualisation, image quantification, and bespoke analysis. Results Over the past seven years, the XRH facility has successfully completed over 120 projects in collaboration with researchers from 60 affiliations, resulting in numerous published manuscripts and conference proceedings. The facility has streamlined the μCT imaging process, improving productivity and enabling efficient acquisition of 3D datasets. Discussion & Conclusions The 3D X-ray Histology (XRH) facility at UHS is a pioneering platform in the field of histology and biomedical imaging. To the best of our knowledge, it stands out as the world's first dedicated XRH facility, encompassing every aspect of the imaging process, from user support to data generation, analysis, training, archiving, and metadata generation. This article serves as a comprehensive guide for establishing similar XRH facilities, covering key aspects of facility setup and operation. Researchers and institutions interested in developing state-of-the-art histology and imaging facilities can utilise this resource to explore new frontiers in their research and discoveries.
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- 2023
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15. Activated carbon nanospheres as high-power and -energy supercapacitor electrodes
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Ratnayaka, Akash
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supercapacitor ,energy storage ,Electrochemical Impedance ,EIS ,Activated Carbon ,Nanospheres - Abstract
Supercapacitors have seen significant study as an additional electrochemical energy storage technology. Due in large part to their high specific power, they have seen growing application for rapid energy storage, or for the delivery of large bursts of power in a short amount of time. However, there is still a desire to enhance their specific energy without sacrificing that specific power. In this work, the synthesis and novel use of activated carbon spheres between 300 and 400 nm with an exceptionally high specific surface area of 2972 m2/g were used as electrode materials for supercapacitors. When this material was used in an aqueous symmetric device, specific energies of up to 10.59 Wh/kg were obtained at a high specific power of 5.15 kW/kg. This performance was achieved with less than 1% capacitance loss over 10,000 galvanostatic charge-discharge cycles. Finally, a novel and facile electrodeposition of manganese oxide using potassium permanganate solution was described. The technique was found to have a high degree of uniformity in deposition, and the ability to tune the thickness of the deposition layer. The manganese oxide deposited was characterised using a range of techniques and found to behave closely to that of birnessite-type manganese oxide. When deposited onto electrodes with activated carbon spheres, the manganese oxide layer conformed to the spherical surface well. These activated carbon sphere-manganese oxide core-shell electrodes were used in asymmetric two-electrode pseudocapacitors where a specific energy of 5.24 Wh/kg at a specific power of 819 W/kg was achieved.
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- 2021
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16. A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy
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Adnan H. Khan, Sudha Priya Soundara Pandi, Jennifer A. Scott, Aida Sánchez-Bretaño, Savannah A. Lynn, J. Arjuna Ratnayaka, Jessica L. Teeling, and Andrew J. Lotery
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Medicine ,Science - Abstract
Abstract There are no disease-modifying treatments available for geographic atrophy (GA), the advanced form of dry age-related macular degeneration. Current murine models fail to fully recapitulate the features of GA and thus hinder drug discovery. Here we describe a novel mouse model of retinal degeneration with hallmark features of GA. We used an 810 nm laser to create a retinal lesion with central sparing (RLCS), simulating parafoveal atrophy observed in patients with progressive GA. Laser-induced RLCS resulted in progressive GA-like pathology with the development of a confluent atrophic lesion. We demonstrate significant changes to the retinal structure and thickness in the central unaffected retina over a 24-week post-laser period, confirmed by longitudinal optical coherence tomography scans. We further show characteristic features of progressive GA, including a gradual reduction in the thickness of the central, unaffected retina and of total retinal thickness. Histological changes observed in the RLCS correspond to GA pathology, which includes the collapse of the outer nuclear layer, increased numbers of GFAP + , CD11b + and FcγRI + cells, and damage to cone and rod photoreceptors. We demonstrate a laser-induced mouse model of parafoveal GA progression, starting at 2 weeks post-laser and reaching confluence at 24 weeks post-laser. This 24-week time-frame in which GA pathology develops, provides an extended window of opportunity for proof-of-concept evaluation of drugs targeting GA. This time period is an added advantage compared to several existing models of geographic atrophy.
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- 2023
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17. Institutional Trend in Device Selection for Transcatheter PDA Closure in Premature Infants
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Guyon, Peter, Duster, Nicole, Katheria, Anup, Heyden, Caitlyn, Griffin, Danica, Steinbergs, Ronald, Moreno Rojas, Andres, Ratnayaka, Kanishka, and El-Said, Howaida G.
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- 2022
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18. The disparity between funding for eye research vs. the high cost of sight-loss in the UK
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Dewing, Jennifer M., Lotery, Andrew J., and Ratnayaka, J. Arjuna
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- 2023
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19. Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles
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Natasha D. Ratnayaka-Gamage, Lauren R. Alesi, Nadeen Zerafa, Jessica M. Stringer, and Karla J. Hutt
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DNA repair ,DNA damage ,oocytes ,non-homologous end joining ,fertility ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionThe non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosis, which can lead to accelerated depletion of the ovarian reserve, early loss of fertility and menopause. Therefore, repair of DNA damage is important for preserving the quality of oocytes to sustain fertility across the reproductive lifespan. This study aimed to evaluate the role of KU80 (encoded by the XRCC5 gene) – an essential component of the non-homologous end joining (NHEJ) pathway – in the repair of oocyte DNA DSBs during reproductive ageing, and following insult caused by the DNA-damaging chemotherapies cyclophosphamide and cisplatin.MethodsTo investigate the importance of KU80 following endogenous and exogenous DNA damage, ovaries from conditional oocyte-specific Xrcc5 knockout (Xrcc5 cKO) and wildtype (WT) mice that were aged or exposed to DNA damage-inducing chemotherapy were compared. Ovarian follicles and oocytes were quantified, morphologically assessed and analysed via immunohistochemistry for markers of DNA damage and apoptosis. In addition, chemotherapy exposed mice were superovulated, and the numbers and quality of mature metaphase- II (MII) oocytes were assessed.ResultsThe number of healthy follicles, atretic (dying) follicles, and corpora lutea were similar in Xrcc5 cKO and WT mice at PN50, PN200 and PN300. Additionally, primordial follicle number and ovulation rates were similar in young adult Xrcc5 cKO and WT mice following treatment with cyclophosphamide (75mg/kg), cisplatin (4mg/kg), or vehicle control (saline). Furthermore, KU80 was not essential for the repair of exogenously induced DNA damage in primordial follicle oocytes.DiscussionThese data indicate that KU80 is not required for maintenance of the ovarian reserve, follicle development, or ovulation during maternal ageing. Similarly, this study also indicates that KU80 is not required for the repair of exogenously induced DSBs in the prophase-arrested oocytes of primordial follicles.
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- 2023
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20. A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications [version 1; peer review: 2 approved]
- Author
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Philip J. Basford, Orestis L. Katsamenis, Richard P. Boardman, Stephanie K. Robinson, Peter M. Lackie, Elena Konstantinopoulou, J. Arjuna Ratnayaka, Anton Page, Gareth J. Thomas, Patricia M. Goggin, Ian Sinclair, Simon J. Cox, and Philipp Schneider
- Subjects
3D X-ray Histology ,XRH ,Histology ,microCT ,μCT ,μ-CT ,eng ,Medicine ,Science - Abstract
Background: The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray microfocus computed tomography (μCT) -based technology. This article presents the outcomes of these endeavours and highlights the distinctive characteristics of a μCT facility specifically tailored for 3D X-ray Histology, with primary focus on applications in biomedical research and preclinical and clinical studies. Methods: The UHS houses a unique 3D X-ray Histology (XRH) facility, offering a range of services to national and international clients. The facility employs specialised μCT equipment designed specifically for histology applications, allowing whole-block XRH imaging of formalin-fixed and paraffin-embedded tissue specimens. It also enables correlative imaging by combining μCT imaging with other microscopy techniques, such as immunohistochemistry (IHC) and serial block-face scanning electron microscopy, as well as data visualization, image quantification, and bespoke analysis. Results: Over the past seven years, the XRH facility has successfully completed over 120 projects in collaboration with researchers from 60 affiliations, resulting in numerous published manuscripts and conference proceedings. The facility has streamlined the μCT imaging process, improving productivity, and enabling efficient acquisition of 3D datasets. Conclusions: The 3D X-ray Histology (XRH) facility at UHS is a pioneering platform in the field of histology and biomedical imaging. To the best of our knowledge, it stands out as the world's first dedicated XRH facility, encompassing every aspect of the imaging process, from user support to data generation, analysis, training, archiving, and metadata generation. This article serves as a comprehensive guide for establishing similar XRH facilities, covering key aspects of facility setup and operation. Researchers and institutions interested in developing state-of-the-art histology and imaging facilities can utilize this resource to explore new frontiers in their research and discoveries.
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- 2023
- Full Text
- View/download PDF
21. Shift-of-Perspective Identification Within Legal Cases
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Ratnayaka, Gathika, Rupasinghe, Thejan, de Silva, Nisansa, Gamage, Viraj Salaka, Warushavithana, Menuka, and Perera, Amal Shehan
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Computer Science - Computation and Language - Abstract
Arguments, counter-arguments, facts, and evidence obtained via documents related to previous court cases are of essential need for legal professionals. Therefore, the process of automatic information extraction from documents containing legal opinions related to court cases can be considered to be of significant importance. This study is focused on the identification of sentences in legal opinion texts which convey different perspectives on a certain topic or entity. We combined several approaches based on semantic analysis, open information extraction, and sentiment analysis to achieve our objective. Then, our methodology was evaluated with the help of human judges. The outcomes of the evaluation demonstrate that our system is successful in detecting situations where two sentences deliver different opinions on the same topic or entity. The proposed methodology can be used to facilitate other information extraction tasks related to the legal domain. One such task is the automated detection of counter arguments for a given argument. Another is the identification of opponent parties in a court case.
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- 2019
22. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial
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Robinson, Thompson, Miranda, J. Jaime, Anderson, Craig S., You, Chao, Song, Lili, Parry-Jones, Adrian, Sprigg, Nikola, Durrans, Sophie, Harris, Caroline, Bamford, Ann, Smith, Olivia, Herbert, Robert, Chen, Christopher, Whiteley, William, Hu, Rong, Billot, Laurent, Li, Qiang, Mysore, Jayanthi, Hu, Xin, Zhang, Yao, Liu, Feifeng, Sakamoto, Yuki, You, Shoujiang, Han, Qiao, Crutzen, Bernard, Li, Yunke, Cheung, Emily, Jan, Stephen, Liu, Hueiming, Ouyang, Menglu, Sun, Lingli, Chu, Honglin, Anjum, Anila, Gonzalez Mc Cawley, Francisca, Del Rio, Alejandra, Rimoli, Bruna, Cerantola, Rodrigo, Jeevarajah, Thanushanthan, Kannangara, Madhushani, Joseph, Andrene, Nanayakkara, Chamath, Chen, Xiaoying, Malavera, Alejandra, Zhang, Chunmiao, Yang, Zhao, Li, Brook, Meng, Zhuo, Liu, Leibo, Ning, Yi, Dong, Le, Armenis, Manuela, Lim, Joyce, Monaghan, Helen, Ma, Lu, Li, Xi, Luo, Rui, Cheng, Guojuan, Dong, Yilin, Liu, Ziqin, Wang, Shuihong, Zhang, Ying, Cheng, Jipeng, Shi, Hui, Li, Wenjing, Mou, Langming, Yi, Ping, Chen, Chen, Chen, Xue, Weerawardena, Shalomi, Ellawala, Poornima, Ranasinghe, Enalee, Rodrigo, Chrishmi, Wahab, Kolawala, Adeniyi, Sunday, Pandian, Jeyaraj, Khanna, Megha, Muñoz Venturelli, Paula, González, Francisca, Urrutia Goldsack, Francisca, Wasay, Mohammad, Begum, Dilshad, Pontes-Neto, Octavio, Camilo, Millene, Dias, Francisco, Vincenzi, Octavio, Moro, Carla, Santos, Renata, Texeira, Nara, Longo, Alexandre, Liberato, Rafaela, Martins, Sheila, Pille, Arthur, Chwal, Bruna, Silva, Isabel, Titton, Natacha, Weiss, Gustavo, Mora, Daissy, Ouriques, Magda, Carbonera, Leonardo, Bazan, Rodrigo, Modolo, Gabriel, Winckler, Fernanda, Miranda, Luana, Souza, Juli, Rojo, Alexis, Uslar, Wilhelm, Medel, Lorena, Lopez, Javiera, Herrero, Diego, Lavados, Pablo, Vargas Latorre, Barbara, Conejan, Nathalie, Esparza, Tomas, Sotomayor, Patricio, Wenger, Denisse, Gigoux, Juan Pablo, Letelier, Aldo, Acevedo, Lilian, Moya, Vivianne, Figueroa, Cristian, Vallejos, Nicol, Guerrero, Rodrigo, Velasquez, Mauricio, Vallejos, Jose, Pallauta, Kimerly, Santibanez, Tamara, Queirolo, Angelo, Lobos, Andrea, Jiang, Yongming, Li, Weimin, Huang, Wei, Luo, Ke, Liu, Gangying, Tang, Guanghai, Yang, Guang, Jiang, Hongtao, Zhang, Xu, Jing, Hongyan, Zhu, Sheng, Pu, Bo, Lv, Dong, Kang, Hui, Hu, Qiuping, She, Xiaochun, Jiang, Xiaoming, Chen, Yanli, Yang, Shenghua, He, Jianjun, Li, Zongping, Cheng, Gang, Huang, Hailin, Wang, Xiaoyi, Lin, Jianqiong, Chen, Minhui, Yang, Chenghao, Ding, Hao, Deng, Yunliang, Luo, Fei, Zhang, Rongjun, Wang, Xiaofeng, Zhang, Hongbing, Yang, Xiaoliang, Zhang, Yang, Yang, Chengyi, He, Yu, Liu, Feng, Wang, Rongjie, Zhang, Yuhui, Xin, Xiaodong, Feng, Bin, Hao, Wanru, Song, Chang, Guo, Yun, Jiang, Dehua, Chen, Jie, Tang, Changtong, Zhu, Hongliang, Li, Xin, Cui, Jin, Xu, Haidong, Li, Boyang, Tang, Fusheng, Li, Yuanbin, Gao, Min, Yang, Bo, Xu, Xuejun, Deng, Bing, Zheng, Yi, Ge, Yuanhong, Chen, Keyu, Liu, Yang, Li, Xinshen, Zhong, Tingting, Xu, Jianfeng, Zhang, Hai, Wang, Jiyue, Zhu, Jianxin, Sun, Hanyu, Yu, Fuhua, Zhang, Xueguang, Xu, Jianguo, Zhang, Mingsen, Wang, Bin, Ma, Yiming, Jiang, Donglin, Zhou, Jun, Liu, Cong, Nie, Wenhong, Li, Mingguo, Tian, Tao, Li, Yong, He, Mingfang, Tu, Xiaolong, Wu, Zhengjun, Liu, Hong, Zhong, Dongsheng, Jiang, Rongcai, Sun, Jian, Tian, Ye, Wei, Yingsheng, An, Shuo, Wei, Pingbo, Luo, Le, Lin, Bin, Liu, Gang, Wen, Yan, Cai, Qiang, Chen, Qianxue, Lei, Pan, Li, Zhiyang, Zhang, Meifang, He, Jiaquan, Chen, Yan, Liu, Jun, Liu, Xinghai, Li, Junyan, Chen, Min, Wang, Jing, Zhou, Bingzhi, Ye, Baichun, Zhang, Jiancheng, Zhang, Manyuan, Pan, Xuming, Yu, Xiaoxiang, Xu, Jian, Xiao, Qingbao, Wang, Yuefei, Tao, Liang, Shi, Lin, Zheng, Niandong, You, Guoliang, Lei, Bo, Chen, Shu, Wu, Honggang, Hu, Jin, Zhao, Jianlan, Yu, Jian, Yuan, Qiang, Du, Zhuoying, Tang, Xielin, Li, Qianke, Liu, Shenghua, Yang, Feilong, Xiao, Kui, Luo, Chao, Wang, Guang, Che, Xudong, Teng, Zhipeng, Wan, Wenwu, Li, Jun, Liu, Yu, Fan, Mingbo, Zhang, Tao, Cai, Lun, Ma, Yuan, Ma, Zhifeng, Li, Bin, He, Linlin, Li, Jinghui, Zhang, Weibing, Zhang, Shuxin, Zhang, Hongzhen, Dai, Yingguang, Lei, Jun, Mao, Lei, Huang, Yiyang, Zhou, Zhi, Chen, Ping, Chen, Fang, Wei, Pan, Li, Tiangui, Chen, Honglin, Zeng, Mengfei, Mou, Kejie, Xue, Jun, Jiang, Yong, Tang, Xiaoping, Chen, Tao, Zhang, Yalan, Xu, Yanbing, Gu, Yuchen, Chen, Lei, Zhao, Yujun, Yang, Bin, Kuai, Peng, Wang, Xi, Yang, Yuwang, Hu, Xueling, Zhang, Huitian, Yang, Yintao, Wang, Weifeng, Zhang, Junyi, Cheng, Wei, Zhang, Xiaoxue, Ma, Xiaowen, He, Qin, Zhang, Li, Gao, Rong, Liu, Huixiang, Ye, Jingwei, Xu, Ping, Wu, Xin, Yuan, Yuan, Zou, Peng, Zhang, Zhen, Cheng, Jiyong, Zhou, Zhangming, Zeng, Yijun, Liang, Zhang, Du, Deming, Yu, Shui, Cao, Yongjun, Xu, Jiaping, Huang, Zhichao, Chen, Dongqin, Xiao, Wenfeng, Zhu, Li, Yuan, Miao, Wang, Yuhai, Shi, Dongliang, Hu, Xu, Xiang, Dingchao, Shi, Like, Wang, Hongqin, Yang, Liu, Miao, Wang, Hu, Yiyi, Zhao, Yuchun, Hu, Xi, Zhou, Weiduo, Sun, Chao, Tang, Dong, Yao, Kun, You, Jin, Chen, Shishi, Yao, Jianmin, Li, Huanmei, Liu, Jinmei, Bai, Ailin, Yi, Yong, Deng, Qingshan, Luo, Peng, Wang, Han, Jiang, Jingcheng, Yang, Qingwei, He, Shunpo, Wang, Jun, Chen, Yu, He, Hua, Deng, Yuyang, Cao, Zhikai, Yi, Xuxia, Luo, Jinbiao, Luo, Shuang, Gong, Min, Liu, Li, Gao, Xuejun, Liu, Jia, Wu, Li'e, Zhang, Jia, Sun, Hongying, Li, Xinhui, Jia, Lu, Wu, Jianbing, Zhang, Jie, Zhang, Huajun, Du, Chunfu, Li, Shun, Yang, Xiaobin, He, Jie, Liao, Lei, Zhou, Gezhi, Dong, Wentao, Chen, Yunxiang, Lin, Xiaofeng, Shui, Xujian, Zhang, Peng, Zhao, Yuan, Yang, Hongli, Zhao, Wenbin, Zhang, Xiaoyi, Chen, Jincao, Wu, Qian, Dai, Xuan, Tang, Baogui, Wang, Yinjuan, Liu, Tao, Zhang, Haixia, Duan, Faliang, Luo, Ming, Jiao, Qingfang, Lei, Guoliang, Wang, Dong, Song, Chunwang, Tan, Haopeng, Ye, Feng, Qin, Xinghu, Liang, Xiaolong, Liu, Junling, Yang, Lang, Yang, Jie, Lin, Yapeng, Yang, Qian, Ma, Xuntai, Qi, Yinkuang, Pan, Baogen, Jiang, Caixia, Ye, Zhanying, Dong, Ce, Yue, Xiongfei, Yang, Xiaopeng, Maimaitiyiming, Tuoheti, Dong, Jun, Wu, Yonggang, Gao, Feng, Zhao, Deqiang, Zhang, Xinghai, Wang, PengJun, Jiang, Hongbo, Li, Jianping, Zhang, Wei, Chen, Jing, Tong, Haibo, Wang, Yonghong, Qiao, Kaipeng, Guo, Fuyou, Zhang, Mingchu, Hu, Yan, Feng, Mengzhao, Song, Dengpan, Zuo, Yi, Chen, Shangjun, Qian, Chao, Li, Baoming, Ma, Jingku, Zhang, Sunfu, Kong, Bin, Dong, Xingyu, Fang, Sheng, Lu, Bin, Li, Yang, Yang, Yongling, Yu, Hong, Sun, Huaiyu, Wang, Yue, Wang, Weimin, Li, Tong, Li, Shengli, Xu, Zhiming, Wang, Yongyi, Dong, Qiang, Tang, Yuping, Chu, Heling, Lu, Ying, Wang, Zhong, Sun, Xiaoou, Zhao, Jianhua, Yang, Shuaifeng, Qian, Xiying, Saroja, Aralikatte Onkarappa, Naik k, Ravishankar, Chindhi, Sandip, Pampaniya, Nakul, Amaresh, Kurubara, Iype, Thomas, R, Dileep, Rajan, Reeja, Panicker, Praveen, Das, Rupjyoti, Choudhury, Nupur, Gohain, Pankaja, Webster, Jemin, Pakma, Biyol, Sangi, Lalbiak, Sebastian, Ivy, Aggrawal, Gaurav, Raj, Komal, Rajoura, Deepankshi, Singh, Sulena, Aggrawal, Varun, Narang, Amit, Arauz, Antonio, Cano-Nigenda, Vanesa, López-Mena, Diego, Valdez-Ruvalcaba, Héctor, Toledo-Treviño, Roberto, Obiako, Reginald, Abubakar, Sani, Emeka, Oguike, Olayemi, Balogun, Lois, Melika, Philip, Ibinaiye, Comfort O, Olurishe, Okubadejo, Njideka, Agabi, Osigwe, Ojo, Oluwadamilola, Wahab, Kolawole, Bello, Abiodun, Ibukun, Oyinloye, Sanayaolu, Olufemi, Jimoh, Abdulraheem, Waheed, Shahid, Kamal, Dr.Ayeesha, Shoaib, Raja Farhat, Orooj, Fizza, Majid, Sadaf, Zehra, Taskeen, Khan, Abdus Salam, Shanker, Ravi, Syed, Nadir Ali, Ahmad, Nashwa, Abanto, Carlos, Valencia, Ana, Barrientos, Danny, Ramirez, Jorge, Calle, Pilar, Palliyeguruge, Dilum, Muthucumarana, Sumudu, Ratnayaka, Shiroma, Ganihiarachchi, Dilhara, Bandaranayake, Arundathi, Somaratne, S.D.B, Narayana, Saumya, Gallage, Sithara, Senanayake, Bimsara, Samarasiri, Udari, Luke, Dunya, Sivapathasundaram, Mythily, Sahadevan, Vithoosan, Rasmi, Amani, Deshaka, Yuran, Fernando, Nilukshi, Munasinghe, Aruna, Rathnapriya, Kapilanga, Nissanka, A.S, Karunathilake, Kanchana, Gayan, Isuru, Wijenayake, Kaminda, Gunasekara, Hasitha, Vidyarathne, Jagath, Keshavaraj, Ajantha, Janarthanan, Kanagasabapathy, Gerald Jeevathasan, Arhivalaky, Sivamainthan, Sivaram, John Priyanth, Mathyamuthan, John Priyanth, Abirami, Rajendiran, Thambippillai, Alwis, Sanjeewa, Gunasekare, Nushara, Liyanarachchi, Vasundara, Dissanayake, Athula, Uluwattage, Wimalasiri Mewa, Ratnayake, Gimhani, Rajinee, Charika, Jayawardana, Sakura, Peiris, Janaka, Wicramasinghe, Ranjith, Fernando, Chamila, Abbas, Jessie, Withanage, Nethmini, Bandara, Makaranda, Mai, Duy Ton, Nguyen, Van Chi, Dao, Viet Phuong, Vuong, Xuan Trung, Nguyen, Tien Dung, Dinh, Trung Hieu, Phan, Ha Quan, Bui, Quoc Viet, Phung, Dinh Tho, Pham, Quang Tho, Pham, Dinh Dai, Do, Duc Thuan, Dang, Phuc Duc, Dang, Minh Duc, Nguyen, Dang Hai, Nguyen, Thi Phuong Nga, Nguyen, Quoc Huy, Pham, Quoc Dai, Chau, Quoc Vinh, Tai, Vinh Thy Van, Le, Tran Vinh, Le, Cong Tri, Tran, Ha Mai Khuong, Nguyen, Huu Khanh, Ngyen, Hoang Minh Thao, Vo, Duc Chien, Nguyen, Thai My Phuong, Tran, Trung Thanh, Vo, Thi Hanh Vi, Cao, Hao Nhien, Nguyen, Ba Thang, Le, Thi Ngoc Suong, La, Thien Duc, Pham, Chi Duc, Thai, Huy, Muñoz-Venturelli, Paula, de Silva, Asita, Thang, Nguyen Huy, Wahab, Kolawole W, Pandian, Jeyaraj D, Pontes-Neto, Octavio M, Shi, Haiping, Wang, Xia, Zhao, Yang, Li, Hao, Liu, Yi, Jiang, Yan, Wu, Bo, Liu, Ming, and Anderson, Craig S
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- 2023
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23. Alternative Access in Congenital Heart Disease.
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Heyden, Caitlin M, Moore, John W, Ryan, Justin R, Lederman, Robert J, El-Said, Howaida G, and Ratnayaka, Kanishka
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adult congenital heart disease ,congenital heart disease ,endovascular ,transcatheter electrosurgery ,transcaval access - Abstract
Limited arterial vascular access precluded necessary transcatheter intervention in a 22-year-old woman with repaired interrupted aortic arch type B. Alternative transcaval vascular access enabled percutaneous therapy. This practice evolution is likely to benefit the growing numbers of adults with congenital heart disease. (Level of Difficulty: Advanced.).
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- 2020
24. An On-Campus Botanical Tour to Promote Student Satisfaction and Learning in a University Level Biodiversity or General Biology Course
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Ratnayaka, Harish H.
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Outdoor, hands-on and experiential learning, as opposed to instruction-based learning in classroom, increases student satisfaction and motivation leading to a deeper understanding of the subject. However, the use of outdoor exercises in undergraduate biology courses is declining due to a variety of constraints. Thus, the goal of this paper is to describe a convenient, no-cost and flexible exercise using an on-campus botanical tour for strengthening specific knowledge areas of major plant groups. Its assessment on conduct and coverage, and student-perceived and actual knowledge gain is also described. Data presented derived from traditional biology undergraduates in sophomore year over nine fall and three spring semesters. Conduct and coverage was assessed using a summative survey including open-ended questions administered to 198 students. A pre- and post-exercise survey addressing 10 knowledge categories was administered to 139 students to evaluate student-perceived knowledge gain. Quiz grades from the on-campus tour exercise were compared with average quiz grades from two in-class plant-related labs of 234 students to assess actual knowledge gain. Each student reporting on the conduct and coverage indicated either one or a combination of outcomes of the exercise as positive engagement, experiential learning, or of interest. Student-perceived improvement was evident in all ten knowledge categories with a greater improvement in categories learned anew during exercise compared to subjects reviewed. Quiz grades from the exercise were >11% greater than quiz grades from the two in-class plant-related labs. Active learning with interest likely contributed to the increased perceived and actual knowledge gains. Suggestions for adoption of the exercise in different settings are presented based on both student comments and instructor's experience.
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- 2017
25. Effectiveness Of Online Reputation Management In Moderating The Connection Between User-Created Content And The Online Reputation Of Destination Management Companies; With Special Reference To The Sri Lanka Tourism Industry
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Ratnayaka, Ruwan, primary
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- 2024
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26. Fast Approach to Build an Automatic Sentiment Annotator for Legal Domain using Transfer Learning
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Gamage, Viraj, Warushavithana, Menuka, de Silva, Nisansa, Perera, Amal Shehan, Ratnayaka, Gathika, and Rupasinghe, Thejan
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Computer Science - Computation and Language - Abstract
This study proposes a novel way of identifying the sentiment of the phrases used in the legal domain. The added complexity of the language used in law, and the inability of the existing systems to accurately predict the sentiments of words in law are the main motivations behind this study. This is a transfer learning approach, which can be used for other domain adaptation tasks as well. The proposed methodology achieves an improvement of over 6\% compared to the source model's accuracy in the legal domain., Comment: 9 pages, 3 figures
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- 2018
27. Identifying Relationships Among Sentences in Court Case Transcripts Using Discourse Relations
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Ratnayaka, Gathika, Rupasinghe, Thejan, de Silva, Nisansa, Warushavithana, Menuka, Gamage, Viraj, and Perera, Amal Shehan
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Computer Science - Computation and Language ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Case Law has a significant impact on the proceedings of legal cases. Therefore, the information that can be obtained from previous court cases is valuable to lawyers and other legal officials when performing their duties. This paper describes a methodology of applying discourse relations between sentences when processing text documents related to the legal domain. In this study, we developed a mechanism to classify the relationships that can be observed among sentences in transcripts of United States court cases. First, we defined relationship types that can be observed between sentences in court case transcripts. Then we classified pairs of sentences according to the relationship type by combining a machine learning model and a rule-based approach. The results obtained through our system were evaluated using human judges. To the best of our knowledge, this is the first study where discourse relationships between sentences have been used to determine relationships among sentences in legal court case transcripts., Comment: Conference: 2018 International Conference on Advances in ICT for Emerging Regions (ICTer)
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- 2018
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28. Urban habitat use and home ranges of fishing cats in Colombo, Sri Lanka
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Ratnayaka, Anya A. W., Serieys, Laurel E. K., Prasad, Tharaka, Leighton, Gabriella R. M., Sanderson, James G., and Leung, Luke K.-P.
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- 2022
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29. Legal Party Extraction from Legal Opinion Texts Using Recurrent Deep Neural Networks.
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Chamodi Samarawickrama, Melonie de Almeida, Nisansa de Silva, Gathika Ratnayaka, and Amal Shehan Perera
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- 2022
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30. SigmaLaw PBSA - A Deep Learning Approach For Aspect Based Sentiment Analysis in Legal Opinion Texts.
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Isanka Rajapaksha, Chanika Ruchini Mudalige, Dilini Karunarathna, Nisansa de Silva, Gathika Ratnayaka, and Amal Shehan Perera
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- 2022
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31. Evidence that the Ser192Tyr/Arg402Gln in cis Tyrosinase gene haplotype is a disease-causing allele in oculocutaneous albinism type 1B (OCA1B)
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Lin, Siying, Sanchez-Bretaño, Aida, Leslie, Joseph S., Williams, Katie B., Lee, Helena, Thomas, N. Simon, Callaway, Jonathan, Deline, James, Ratnayaka, J. Arjuna, Baralle, Diana, Schmitt, Melanie A., Norman, Chelsea S., Hammond, Sheri, Harlalka, Gaurav V., Ennis, Sarah, Cross, Harold E., Wenger, Olivia, Crosby, Andrew H., Baple, Emma L., and Self, Jay E.
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- 2022
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32. EMPIRICAL REVIEW ON EVOLUTION OF INTERNET AND THE ONLINE REPUTATION OF DESTINATION MANAGEMENT COMPANIES; WITH SPECIAL REFERENCE TO SRI LANKA TOURISM INDUSTRY.
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Ratnayaka, Ruwan, Tham, Jacquline, Azam, Ferdous, and Shukri, Sakinah Mohd
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DESTINATION management companies ,DIGITAL technology ,TOURISM ,REPUTATION ,USER-generated content ,CONSUMER behavior ,INTERNET - Abstract
Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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33. INTEGRATED FRAMEWORKS FOR EFFECTIVE ONLINE REPUTATION MANAGEMENT: A COMPREHENSIVE REVIEW OF THEORETICAL MODELS AND INTERCONNECTIONS.
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Ratnayaka, Ruwan, Tham, Jacquline, Azam, Ferdous, and Shukri, Sakinah Mohd
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INTERNET content ,USER-generated content ,CONTENT marketing ,DIGITAL technology ,LITERATURE reviews ,REPUTATION ,ACQUISITION of data ,MARKETING theory ,METHODOLOGY - Abstract
Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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34. Identifying Legal Party Members from Legal Opinion Documents using Natural Language Processing.
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Melonie de Almeida, Chamodi Samarawickrama, Nisansa de Silva, Gathika Ratnayaka, and Amal Shehan Perera
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- 2021
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35. Sigmalaw PBSA - A Deep Learning Model for Aspect-Based Sentiment Analysis for the Legal Domain.
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Isanka Rajapaksha, Chanika Ruchini Mudalige, Dilini Karunarathna, Nisansa de Silva, Amal Shehan Perera, and Gathika Ratnayaka
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- 2021
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36. Sigmalaw PBSA - A Deep Learning Model for Aspect-Based Sentiment Analysis for the Legal Domain
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Rajapaksha, Isanka, Mudalige, Chanika Ruchini, Karunarathna, Dilini, de Silva, Nisansa, Perera, Amal Shehan, Ratnayaka, Gathika, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Strauss, Christine, editor, Kotsis, Gabriele, editor, Tjoa, A Min, editor, and Khalil, Ismail, editor
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- 2021
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37. Evidence that the Ser192Tyr/Arg402Gln in cis Tyrosinase gene haplotype is a disease-causing allele in oculocutaneous albinism type 1B (OCA1B)
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Siying Lin, Aida Sanchez-Bretaño, Joseph S. Leslie, Katie B. Williams, Helena Lee, N. Simon Thomas, Jonathan Callaway, James Deline, J. Arjuna Ratnayaka, Diana Baralle, Melanie A. Schmitt, Chelsea S. Norman, Sheri Hammond, Gaurav V. Harlalka, Sarah Ennis, Harold E. Cross, Olivia Wenger, Andrew H. Crosby, Emma L. Baple, and Jay E. Self
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Medicine ,Genetics ,QH426-470 - Abstract
Abstract Oculocutaneous albinism type 1 (OCA1) is caused by pathogenic variants in the TYR (tyrosinase) gene which encodes the critical and rate-limiting enzyme in melanin synthesis. It is the most common OCA subtype found in Caucasians, accounting for ~50% of cases worldwide. The apparent ‘missing heritability’ in OCA is well described, with ~25–30% of clinically diagnosed individuals lacking two clearly pathogenic variants. Here we undertook empowered genetic studies in an extensive multigenerational Amish family, alongside a review of previously published literature, a retrospective analysis of in-house datasets, and tyrosinase activity studies. Together this provides irrefutable evidence of the pathogenicity of two common TYR variants, p.(Ser192Tyr) and p.(Arg402Gln) when inherited in cis alongside a pathogenic TYR variant in trans. We also show that homozygosity for the p.(Ser192Tyr)/p.(Arg402Gln) TYR haplotype results in a very mild, but fully penetrant, albinism phenotype. Together these data underscore the importance of including the TYR p.(Ser192Tyr)/p.(Arg402Gln) in cis haplotype as a pathogenic allele causative of OCA, which would likely increase molecular diagnoses in this missing heritability albinism cohort by 25–50%.
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- 2022
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38. Endograft rescue of compromised interposition aortic graft in an adult patient with congenital heart disease.
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Lee, Jesse W, Ratnayaka, Kanishka, El-Said, Howaida G, and Moore, John W
- Abstract
In a 19-year-old male with interrupted aortic arch and complex congenital heart disease, we report percutaneous repair of a compromised aortic conduit. The patient had aortic arch repair in childhood utilizing a 12 mm Hemashield Dacron conduit. CT angiography showed multiple segments of this conduit were dilated to 16 mm suggesting conduit degeneration and failure with pseudoaneurysm formation. We utilized a self-expanding aortic endograft supported by internal placement of bare metal stents to repair the conduit. Our repair was guided by 3D rotational angiography. This adult patient with complex congenital heart disease and interrupted aortic arch is an example of patients in whom endograft repair of compromised aortic conduits presents a much lower risk alternative than surgical revision.
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- 2018
39. Physiological Recording in the MRI Environment (PRiME): MRI-Compatible Hemodynamic Recording System
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Kakareka, John W, Faranesh, Anthony Z, Pursley, Randall H, Campbell-Washburn, Adrienne, Herzka, Daniel A, Rogers, Toby, Kanter, Josh, Ratnayaka, Kanishka, Lederman, Robert J, and Pohida, Thomas J
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Engineering ,Biomedical Engineering ,Clinical Research ,Cardiovascular ,Biomedical Imaging ,Bioengineering ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Adaptive signal processing ,biomedical electronics ,biomedical equipment ,biomedical signal processing ,cardiology ,catheterization ,magnetic resonance imaging ,Biomedical engineering ,Health services and systems - Abstract
Hemodynamic recording during interventional cardiovascular procedures is essential for procedural guidance, monitoring patient status, and collection of diagnostic information. Recent advances have made interventions guided by magnetic resonance imaging (MRI) possible and attractive in certain clinical scenarios. However, in the MRI environment, electromagnetic interference (EMI) can cause severe distortions and artifacts in acquired hemodynamic waveforms. The primary aim of this paper was to develop and validate a system to minimize EMI on electrocardiogram (ECG) and invasive blood pressure (IBP) signals. A system was developed which incorporated commercial MRI compatible ECG leads and pressure transducers, custom electronics, user interface, and adaptive signal processing. Measurements were made on pediatric patients (N = 6) during MRI-guided catheterization. Real-time interactive scanning, which is known to produce significant EMI due to fast gradient switching and varying imaging plane orientations, was selected for testing. The effectiveness of the adaptive algorithms was determined by measuring the reduction of noise peaks, amplitude of noise peaks, and false QRS triggers. During real-time gradient-intensive imaging sequences, peak noise amplitude was reduced by 80% and false QRS triggers were reduced to a median of 0. There was no detectable interference on the IBP channels. A hemodynamic recording system front-end was successfully developed and deployed, which enabled high-fidelity recording of ECG and IBP during MRI scanning. The schematics and assembly instructions are publicly available to facilitate implementation at other institutions. Researchers and clinicians are provided a critical tool in investigating and implementing MRI guided interventional cardiovascular procedures.
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- 2018
40. Radiation-free CMR diagnostic heart catheterization in children
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Ratnayaka, Kanishka, Kanter, Joshua P, Faranesh, Anthony Z, Grant, Elena K, Olivieri, Laura J, Cross, Russell R, Cronin, Ileen F, Hamann, Karin S, Campbell-Washburn, Adrienne E, O’Brien, Kendall J, Rogers, Toby, Hansen, Michael S, and Lederman, Robert J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Pediatric Research Initiative ,Heart Disease ,Clinical Research ,Patient Safety ,Biomedical Imaging ,Cardiovascular ,Pediatric ,Bioengineering ,Adolescent ,Age Factors ,Cardiac Catheterization ,Child ,Feasibility Studies ,Female ,Heart Diseases ,Hemodynamics ,Humans ,Magnetic Resonance Imaging ,Interventional ,Male ,Predictive Value of Tests ,Radiation Exposure ,Time Factors ,Catheterization ,Magnetic Resonance Imaging ,Interventional Cardiovascular MRI ,Real-time MRI ,MRI fluoroscopy ,Cardiorespiratory Medicine and Haematology ,Nuclear Medicine & Medical Imaging ,Cardiovascular medicine and haematology - Abstract
BackgroundChildren with heart disease may require repeated X-Ray cardiac catheterization procedures, are more radiosensitive, and more likely to survive to experience oncologic risks of medical radiation. Cardiovascular magnetic resonance (CMR) is radiation-free and offers information about structure, function, and perfusion but not hemodynamics. We intend to perform complete radiation-free diagnostic right heart catheterization entirely using CMR fluoroscopy guidance in an unselected cohort of pediatric patients; we report the feasibility and safety.MethodsWe performed 50 CMR fluoroscopy guided comprehensive transfemoral right heart catheterizations in 39 pediatric (12.7 ± 4.7 years) subjects referred for clinically indicated cardiac catheterization. CMR guided catheterizations were assessed by completion (success/failure), procedure time, and safety events (catheterization, anesthesia). Pre and post CMR body temperature was recorded. Concurrent invasive hemodynamic and diagnostic CMR data were collected.ResultsDuring a twenty-two month period (3/2015 - 12/2016), enrolled subjects had the following clinical indications: post-heart transplant 33%, shunt 28%, pulmonary hypertension 18%, cardiomyopathy 15%, valvular heart disease 3%, and other 3%. Radiation-free CMR guided right heart catheterization attempts were all successful using passive catheters. In two subjects with septal defects, right and left heart catheterization were performed. There were no complications. One subject had six such procedures. Most subjects (51%) had undergone multiple (5.5 ± 5) previous X-Ray cardiac catheterizations. Retained thoracic surgical or transcatheter implants (36%) did not preclude successful CMR fluoroscopy heart catheterization. During the procedure, two subjects were receiving vasopressor infusions at baseline because of poor cardiac function, and in ten procedures, multiple hemodynamic conditions were tested.ConclusionsComprehensive CMR fluoroscopy guided right heart catheterization was feasible and safe in this small cohort of pediatric subjects. This includes subjects with previous metallic implants, those requiring continuous vasopressor medication infusions, and those requiring pharmacologic provocation. Children requiring multiple, serial X-Ray cardiac catheterizations may benefit most from radiation sparing. This is a step toward wholly CMR guided diagnostic (right and left heart) cardiac catheterization and future CMR guided cardiac intervention.Trial registrationClinicalTrials.gov NCT02739087 registered February 17, 2016.
- Published
- 2017
41. CMR fluoroscopy right heart catheterization for cardiac output and pulmonary vascular resistance: results in 102 patients
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Rogers, Toby, Ratnayaka, Kanishka, Khan, Jaffar M, Stine, Annette, Schenke, William H, Grant, Laurie P, Mazal, Jonathan R, Grant, Elena K, Campbell-Washburn, Adrienne, Hansen, Michael S, Ramasawmy, Rajiv, Herzka, Daniel A, Xue, Hui, Kellman, Peter, Faranesh, Anthony Z, and Lederman, Robert J
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Lung ,Cardiovascular ,Clinical Trials and Supportive Activities ,Bioengineering ,Heart Disease ,Biomedical Imaging ,Clinical Research ,Administration ,Inhalation ,Adult ,Aged ,Cardiac Catheterization ,Cardiac Output ,Case-Control Studies ,Female ,Fluoroscopy ,Humans ,Hypertension ,Pulmonary ,Magnetic Resonance Imaging ,Interventional ,Male ,Middle Aged ,Models ,Cardiovascular ,Nitric Oxide ,Oxygen ,Predictive Value of Tests ,Prospective Studies ,Pulmonary Artery ,Time Factors ,Vascular Resistance ,Interventional MRI catheterization ,Right heart catheterization ,Invasive hemodynamics ,Phase contrast MRI flow ,Real-time MRI ,CMR ,Cardiac MRI ,Cardiorespiratory Medicine and Haematology ,Nuclear Medicine & Medical Imaging ,Cardiovascular medicine and haematology - Abstract
BackgroundQuantification of cardiac output and pulmonary vascular resistance (PVR) are critical components of invasive hemodynamic assessment, and can be measured concurrently with pressures using phase contrast CMR flow during real-time CMR guided cardiac catheterization.MethodsOne hundred two consecutive patients underwent CMR fluoroscopy guided right heart catheterization (RHC) with simultaneous measurement of pressure, cardiac output and pulmonary vascular resistance using CMR flow and the Fick principle for comparison. Procedural success, catheterization time and adverse events were prospectively collected.ResultsRHC was successfully completed in 97/102 (95.1%) patients without complication. Catheterization time was 20 ± 11 min. In patients with and without pulmonary hypertension, baseline mean pulmonary artery pressure was 39 ± 12 mmHg vs. 18 ± 4 mmHg (p
- Published
- 2017
42. The Influence Of Firm Created And User Created Contents On The Online Reputation Of Destination Management Companies In Sri Lanka Tourism Industry
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Ratnayaka, Ruwan, primary
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- 2024
- Full Text
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43. Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
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Ma, Jingyi, primary, Al Moussawi, Khatoun, additional, Lou, Hantao, additional, Chan, Hok Fung, additional, Wang, Yihua, additional, Chadwick, Joseph, additional, Phetsouphanh, Chansavath, additional, Slee, Elizabeth A., additional, Zhong, Shan, additional, Leissing, Thomas M., additional, Roth, Andrew, additional, Qin, Xiao, additional, Chen, Shuo, additional, Yin, Jie, additional, Ratnayaka, Indrika, additional, Hu, Yang, additional, Louphrasitthiphol, Pakavarin, additional, Taylor, Lewis, additional, Bettencourt, Paulo J. G., additional, Muers, Mary, additional, Greaves, David R., additional, McShane, Helen, additional, Goldin, Robert, additional, Soilleux, Elizabeth J., additional, Coleman, Mathew L., additional, Ratcliffe, Peter J., additional, and Lu, Xin, additional
- Published
- 2024
- Full Text
- View/download PDF
44. Effective Approach to Develop a Sentiment Annotator For Legal Domain in a Low Resource Setting.
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Gathika Ratnayaka, Nisansa de Silva, Amal Shehan Perera, and Ramesh Pathirana
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- 2020
45. Enhancing the Identification of Cyberbullying through Participant Roles.
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Gathika Ratnayaka, Thushari Atapattu, Mahen Herath, Georgia Zhang, and Katrina Falkner
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- 2020
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- View/download PDF
46. SigmaLaw-ABSA: Dataset for Aspect-Based Sentiment Analysis in Legal Opinion Texts.
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Chanika Ruchini Mudalige, Dilini Karunarathna, Isanka Rajapaksha, Nisansa de Silva, Gathika Ratnayaka, Amal Shehan Perera, and Ramesh Pathirana
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- 2020
- Full Text
- View/download PDF
47. Party Identification of Legal Documents using Co-reference Resolution and Named Entity Recognition.
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Chamodi Samarawickrama, Melonie de Almeida, Nisansa de Silva, Gathika Ratnayaka, and Amal Shehan Perera
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- 2020
- Full Text
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48. Evaluation of learning environment among Nursing undergraduates in state universities, Sri Lanka
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Patalee Jayaweera, Abisheka Thilakarathne, Madushanka Ratnayaka, Tharangi Shashikala, Rushani Arachchige, Lahiru Sandaruwan Galgamuwa, Nimantha Karunathilaka, and Thamara Amarasekara
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Evaluation ,Learning Environment ,Nursing Undergraduates ,The Dundee Ready Educational Environment Measure ,Sri Lanka ,and State Universities ,Nursing ,RT1-120 - Abstract
Abstract Background The learning environment is a vital part of the undergraduate curriculum which enable to delivery of quality education in the stipulated time. Therefore, this study aimed to evaluate the learning environment among BSc. Nursing undergraduates in Sri Lankan state universities. Methods A descriptive cross-sectional study was conducted among 161 final year BSc. Nursing undergraduates in six state universities. Socio-demographic characteristics were collected using a self-administered questionnaire. The Dundee Ready Educational Environment Measure (DREEM) questionnaire was used to evaluate the learning environment in Perception of learning (SPL), Perceptions of teaching (SPT), Academic self-perceptions (SASP), Perceptions of the atmosphere (SPA), and Social self-perceptions (SSP). Based on the SPL, SPT, SASP, SPA, and SSP domains, the overall score of learning environment was ranged from 0 to 200 and then the overall score was classified into four categories such as poor (0–50), many problems (51–100), more positive than negative (101–150) and excellent (151–200). One-way Analysis of Variance (ANOVA) and t-test were used to determine the difference in the subscales and the overall scale. Results The mean age of the students was 24.9 ± 0.9 years. The overall score of the learning environment was 127.1 ± 14.3. Student’s Perception of learning showed the highest mean score of 31.1 ± 3.9 while the social self-perception showed the lowest score (mean 16.4 ± 3.1). A significant group effect was observed in SPL and SPT subdomains among state universities while no significant group effect was observed in other subdomains. Furthermore, participating in extracurricular activities, travelling time to the faculty, and gender were observed as associated factors for the learning environment among BSc. Nursing undergraduates in state universities. Conclusions Although the overall learning environment of BSc. Nursing undergraduates in state universities in Sri Lanka was within more positive than negative category, none of the university reaches to the excellent category. Therefore, each university should have improved their subdomains of learning environment to reach excellent category through addressing the gaps of curricular and extracurricular activities in the future.
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- 2021
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49. Pulmonary vein rehabilitation
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Aljohani, Othman A., Mackie, Duncan, Frazer, Jeffrey, You, Hyeri, Nageotte, Stephen J., Ratnayaka, Kanishka, Moore, John W., and El-Said, Howaida G.
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- 2021
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50. Serial block face scanning electron microscopy reveals novel organizational details of the retinal pigment epithelium
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J Arjuna Ratnayaka and Eloise Keeling
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2022
- Full Text
- View/download PDF
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