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1. Repeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease

Author

Nicosia, Luca, Allegra, Andrea Gaetano, Giaj-Levra, Niccolò, Bayani, Reyhaneh, Darzikolaee, Nima Mousavi, Mazzola, Rosario, Pastorello, Edoardo, Ravelli, Paolo, Ricchetti, Francesco, Rigo, Michele, Ruggieri, Ruggero, Gurrera, Davide, Borgese, Riccardo Filippo, Gaito, Simona, Minniti, Giuseppe, Navarria, Pierina, Scorsetti, Marta, and Alongi, Filippo

Published
2024
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5. PSMA-PET/CT-Based Stereotactic Body Radiotherapy (SBRT) in the Treatment of Uncomplicated Non-Spinal Bone Oligometastases from Prostate Cancer

Author

Pastorello, Edoardo, primary, Nicosia, Luca, additional, Cuccia, Francesco, additional, Olivari, Laura, additional, Fiorini, Matilde, additional, Giaj Levra, Niccolò, additional, Mazzola, Rosario, additional, Ricchetti, Francesco, additional, Rigo, Michele, additional, Ravelli, Paolo, additional, D’Alessandro, Salvatore, additional, Salgarello, Matteo, additional, Ruggieri, Ruggero, additional, and Alongi, Filippo, additional

Published
2023
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6. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths

Author

Actis, Giovanni, Adamo, Salvatore, Amitrano, Lucio, Amuso, Mariano, Ancarani, Ornella, Angelico, Mario, Antonini, Filippo, Badiali, Danilo, Balzano, Antonio, Bardella, Maria Teresa, Barresi, Luca, Bellentani, Stefano, Bellini, Massimo, Benedetti, Antonio, Biagini, Massimiliano, Bianchi, Sabrina, Bianco, Antonietta, Borro, Paolo, Bortoli, Aurora, Bortoluzzi, Francesco, Borzio, Mauro, Boskovski, Ivo, Brosolo, Piero, Brunelli, Eugenio, Brunetto, Maurizia, Buri, Luigi, Burra, Patrizia, Caletti, Giancarlo, Chilovi, Fausto, Cicala, Michele, Ciliberto, Enrico, Cilona, Antonio, Cipolletta, Livio, Claar, Giovanni M., Conigliaro, Rita, Conio, Massimo, Corazziari, Enrico, Costamagna, Guido, Cottone, Mario, Craxì, Antonio, Crotta, Sergio, Cucchiara, Salvatore, Cupella, Francesco, Cuppone, Renato, D’Amico, Gennaro, D’Imperio, Nicola, De Angelis, Claudio, De Pretis, Giovanni, De Stefano, Salvatore, Del Favero, Giuseppe, Del Piano, Mario, Di Cillo, Michele, Di Leo, Alfredo, Di Matteo, Giovanni, Ederle, Andrea, Elli, Luca, Fagiuoli, Stefano, Familiari, Luigi, Familiari, Pietro, Fava, Gianmarco, Federici, Telemaco, Ferrini, Giovanni, Filiberti, Rosa, Fracasso, Pierluigi, Framarin, Luciana, Fregonese, Diego, Frosini, Giorgio, Frulloni, Luca, Fusaroli, Pietro, Gallo, Vincenzo, Gatto, Gianni, Gemme, Carlo, Germanà, Bastianello, Germani, Giacomo, Guardascione, Francesco, Gullotta, Renzo, Hassan, Cesare, Ingrosso, Marcello, Kohn, Anna, Lauri, Adriano, Leandro, Gioacchino, Leo, Piero, Lorenzini, Ivano, Loriga, Piero, Macarri, Giampiero, Magnolfi, Fabrizio, Manta, Raffaele, Marchi, Santino, Marin, Renato, Marini, Mario, Marino, Antonino, Meroni, Emanuele, Milazzo, Giuseppe, Monastra, Santo, Montalbano, Luigi, Morini, Sergio, Muscatiello, Nicola, Natali, Alessandro, Neri, Matteo, Nucci, Andrea, Pace, Fabio, Pallone, Francesco, Parodi, Maria Caterina, Pasquale, Luigi, Penagini, Roberto, Peralta, Sergio, Peruzzi, Egiziano, Piazzi, Lucia, Quondamcarlo, Cinzia, Radaelli, Franco, Rendina, Maria, Ridolfi, Francesco, Rosina, Floriano, Salmi, Andrea, Sansoè, Giovanni, Scafato, Emanuele, Scarpulla, Giuseppe, Solinas, Attilio, Soncini, Marco, Sorrentini, Italo, Spinzi, Giancarlo, Stroppa, Italo, Sturniolo, Giancarlo, Sumberaz, Alessandro, Tammaro, Leonardo, Tarantino, Ilaria, Testino, Gianni, Traina, Mario, Triossi, Omero, Usai-Satta, Paolo, Vilardo, Luigi, Virgilio, Clara, Zambelli, Alessandro, Zilli, Maurizio, Zullo, Angelo, Buscarini, Elisabetta, Conte, Dario, Cannizzaro, Renato, Bazzoli, Franco, De Boni, Michele, Delle Fave, Gianfranco, Farinati, Fabio, Ravelli, Paolo, Testoni, Pier Alberto, Lisiero, Manola, and Spolaore, Paolo

Published
2014
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7. Migration rate using Fully-covered metal stent in anastomotic strictures after liver transplantation: Results from the BASALT Study Group

Author

Conigliaro, Rita, Pigò, Flavia, Bertani, Helga, Greco, Salvatore, Burti, Cesare, Indriolo, Amedeo, Di Sario, Antonio, Ortolani, Alessio, Maroni, Luca, Tringali, Andrea, Barbaro, Federico, Costamagna, Guido, Magarotto, Andrea, Masci, Enzo, Mutignani, Massimiliano, Forti, Edoardo, Tringali, Alberto, Parodi, Maria Caterina, Assandri, Lorenzo, Marrone, Ciro, Fantin, Alberto, Penagini, Roberto, Cantù, Paolo, Di Benedetto, Fabrizio, Ravelli, Paolo, Vivarelli, Marco, Agnes, Salvatore, Mazzaferro, Vincenzo, De Carlis, Luciano, Andorno, Enzo, Cillo, Umberto, Rossi, Giorgio, Tringali, Andrea (ORCID:0000-0002-9614-3449), Costamagna, Guido (ORCID:0000-0002-8100-2731), Agnes, Salvatore (ORCID:0000-0002-3341-4221), Conigliaro, Rita, Pigò, Flavia, Bertani, Helga, Greco, Salvatore, Burti, Cesare, Indriolo, Amedeo, Di Sario, Antonio, Ortolani, Alessio, Maroni, Luca, Tringali, Andrea, Barbaro, Federico, Costamagna, Guido, Magarotto, Andrea, Masci, Enzo, Mutignani, Massimiliano, Forti, Edoardo, Tringali, Alberto, Parodi, Maria Caterina, Assandri, Lorenzo, Marrone, Ciro, Fantin, Alberto, Penagini, Roberto, Cantù, Paolo, Di Benedetto, Fabrizio, Ravelli, Paolo, Vivarelli, Marco, Agnes, Salvatore, Mazzaferro, Vincenzo, De Carlis, Luciano, Andorno, Enzo, Cillo, Umberto, Rossi, Giorgio, Tringali, Andrea (ORCID:0000-0002-9614-3449), Costamagna, Guido (ORCID:0000-0002-8100-2731), and Agnes, Salvatore (ORCID:0000-0002-3341-4221)

Abstract

Background and study aim: The traditional endoscopic therapy of anastomotic strictures (AS) after orthotopic liver transplantation (OLT) is multiple ERCPs with insertion of an increasing number of plastic stents side-by-side. Fully covered self-expanding metal stents (cSEMS) could be a valuable option to decrease the number of procedures needed or non-responders to plastic stents. This study aims to retrospectively analyze the results of AS endoscopic treatment by cSEMS and to identify any factors associated to its success. Patients and Methods Ninety-one patients (mean age 55.9 ± 7.6 DS; 73 males) from 9 Italian transplantation centers, had a cSEMS positioned for post-OLT AS between 2007 and 2017. 49 (54%) patients were treated with cSEMS as a second-line treatment. Results All the procedures were successfully performed without with no immediate complications. After ERCP, adverse events occurred in 11% of cases (2 moderate pancreatitis, 8 cholangitis). In 49 patients (54%) cSEMSs migrated. After cSEMS removal, 46 patients (51%) needed further endoscopic (45 patients) or radiologic (1 patient) treatments to solve the AS. Lastly, 7 patients underwent surgery. Multivariable stepwise logistic regression showed that cSEMS migration was the only factor associated with further treatments (OR 2.6, 95% CI 1.0-6.6; p-value 0.03); cSEMS implantation before 12 months from OLT was associated with stent migration (OR 5.2, 95% CI 1.7-16.0; p-value 0.004). Conclusions cSEMS appears to be a safe tool to treat AS. cSEMS migration is the main limitation to its routinary implantation and needs to be prevented, probably with the use of new generation anti-migration stents.

Published
2022

8. Management of biliary anastomotic strictures after liver transplantation (BASALT study): A nationwide Italian survey

Author

Cantù, Paolo, Parzanese, Ilaria, Balassone, Valerio, Di Sario, Antonio, Soggiu, Fiammetta, Lombardi, Giovanni, Barbaro, Federico, Pisani, Antonio, Baldan, Anna, Cariani, Giulio, Boarino, Valentina, Fasoli, Alberto, Bertani, Helga, Forti, Edoardo, Bulajic, Milutin, Ghinolfi, Davide, Nadal, Elena, Cerofolini, Angelo, Barresi, Luca, Catalano, Giorgia, Stroppa, Italo, Traini, Sara, Mazzaferro, Vincenzo, Cipolletta, Livio, Tringali, Andrea, Costamagna, Guido, Ravelli, Paolo, Bazzoli, Franco, Merighi, Alberto, Parodi, Maria Caterina, Conigliaro, Rita, Mutignani, Massimiliano, Zilli, Maurizio, Filipponi, Franco, Fantin, Alberto, Rodella, Luca, Tarantino, Ilaria, Traina, Mario, Salizzoni, Mauro, Rosa, Roberto, Malinverno, Federica, Invernizzi, Federica, Angelo Manini, Matteo, Donato, Maria Francesca, Colombo, Massimo, Conte, Dario, Rossi, Giorgio, and Penagini, Roberto

Published
2017
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16. Long-term endoscopic surveillance of patients with Barrett's esophagus. incidence of dysplasia and adenocarcinoma: a prospective study

Author

Conio, Massimo, Blanchi, Sabrina, Lapertosa, Gabriella, Ferraris, Roberto, Sablich, Renato, Marchi, Santino, D'Onofrio, Vittorio, Lacchin, Teresa, Iaquinto, Gaetano, Missale, Guido, Ravelli, Paolo, Cestari, Renzo, Benedetti, Giorgio, Macrì, Giuseppe, Fiocca, Roberto, Munizzi, Francesco, and Filiberti, Rosangela

Published
2003
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17. Endo‐therapies for biliary duct‐to‐duct anastomotic stricture after liver transplantation: Outcomes of a nationwide survey

Author

Cantù, Paolo, primary, Tarantino, Ilaria, additional, Baldan, Anna, additional, Mutignani, Massimiliano, additional, Tringali, Andrea, additional, Lombardi, Giovanni, additional, Cerofolini, Angelo, additional, Di Sario, Antonio, additional, Catalano, Giorgia, additional, Bertani, Helga, additional, Ghinolfi, Davide, additional, Boarino, Valentina, additional, Masci, Enzo, additional, Bulajic, Milutin, additional, Pisani, Antonio, additional, Fantin, Alberto, additional, Ligresti, Dario, additional, Barresi, Luca, additional, Traina, Mario, additional, Ravelli, Paolo, additional, Forti, Edoardo, additional, Barbaro, Federico, additional, Costamagna, Guido, additional, Rodella, Luca, additional, Maroni, Luca, additional, Salizzoni, Mauro, additional, Conigliaro, Rita, additional, Filipponi, Franco, additional, Merighi, Alberto, additional, Staiano, Teresa, additional, Monteleone, Michela, additional, Mazzaferro, Vincenzo, additional, Zucchi, Elena, additional, Zilli, Maurizio, additional, Nadal, Elena, additional, Rosa, Roberto, additional, Santi, Giulio, additional, Parzanese, Ilaria, additional, De Carlis, Luciano, additional, Donato, Maria Francesca, additional, Lampertico, Pietro, additional, Maggi, Umberto, additional, Caccamo, Lucio, additional, Rossi, Giorgio, additional, Vecchi, Maurizio, additional, and Penagini, Roberto, additional

Published
2019
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18. Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation

Author

Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantinos, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantino, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Altomare, D., Annese, V., Badiali, D., Basilisco, G., Bassotti, G., Battaglia, E., Bazzocchi, G., Bellini, M., Bendia, E., Benini, L., Biscaglia, G., Biviano, I., Bocchini, R., Bonventre, S., Bossa, F., Brandimarte, G., Cannizzaro, R., Cicala, M., Cipolletta, L., Clara, V., Cogliandro, R., Comandini, G., Corazziari, E., Crotta, S., Cuomo, R., D'Alba, L., De Giorgi, F., Del Piano, M., Di Fonzo, M., Di Mario, F., Di Stefano, M., D'Onofrio, V., Efthymakis, K., Fiore, P., Fortuna, M., Fries, W., Gaetani, E., Galeazzi, F., Gasbarrini, A., Geccherle, A., Giangregorio, F., Girardi, L., Grassini, M., Groppo, M., Guarnieri, G., Lo Cascio, M., Lolli, R., Luzza, F., Macarri, G., Marino, M., Miraglia, S., Monastra, S., Neri, M., Noris, R., Orselli, S., Passaretti, S., Paviotti, A., Pazzi, P., Pilotto, A., Portincasa, P., Ranaldo, N., Ravelli, P., Rogai, F., Sablich, R., Savarino, V., Spinzi, G., Stanghellini, V., Tammaro, L., Torresan, F., Usai Satta, P., and Valle, C.

Subjects
Adult, Male, Quality of life, medicine.medical_specialty, Constipation, Cross-sectional study, Physiology, Bloating, Chronic constipation, Functional constipation, Irritable bowel syndrome, Patient-reported outcomes, Treatment satisfaction, Endocrine and Autonomic Systems, Gastroenterology, Cross-Sectional Studies, Female, Flatulence, Humans, Irritable Bowel Syndrome, Middle Aged, Prevalence, Quality of Life, Surveys and Questionnaires, Endocrine and Autonomic System, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Patient-reported outcome, Settore MED/12 - Gastroenterologia, business.industry, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Settore MED/18 - Chirurgia Generale, Tolerability, 030220 oncology & carcinogenesis, Physical therapy, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.

Published
2016

19. Celiac Disease Diagnosis Without Biopsy: Is a 10× ULN Antitransglutaminase Result Suitable for a Chemiluminescence Method?

Author

Previtali, Giulia, primary, Licini, Lisa, additional, D’Antiga, Lorenzo, additional, Marseglia, Antonio, additional, Ravasio, Rudi, additional, Nembrini, Francesca, additional, Greco, Salvatore, additional, Sonzogni, Aurelio, additional, Azzarà, Giovanna, additional, Ravelli, Paolo, additional, and Alessio, Maria G., additional

Published
2018
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20. Management of biliary anastomotic strictures after liver transplantation (BASALT study): A nationwide Italian survey

Author

Cantu', Paolo, Parzanese, Ilaria, Balassone, Valerio, Di Sario, Antonio, Soggiu, Fiammetta, Lombardi, Giovanni, Barbaro, Federico, Pisani, Antonio, Baldan, Anna, Cariani, Giulio, Boarino, Valentina, Fasoli, Alberto, Bertani, Helga, Forti, Edoardo, Bulajic, Milutin, Ghinolfi, Davide, Nadal, Elena, Cerofolini, Angelo, Barresi, Luca, Catalano, Giorgia, Stroppa, Italo, Traini, Sara, Mazzaferro, Vincenzo, Cipolletta, Livio, Tringali, Andrea, Costamagna, Guido, Ravelli, Paolo, Bazzoli, Franco, Merighi, Alberto, Parodi, Maria Caterina, Conigliaro, Rita, Mutignani, Massimiliano, Zilli, Maurizio, Filipponi, Franco, Fantin, Alberto, Rodella, Luca, Tarantino, Ilaria, Traina, Mario, Salizzoni, Mauro, Rosa, Roberto, Malinverno, Federica, Invernizzi, Federica, Angelo Manini, Matteo, Donato, Maria Francesca, Colombo, Massimo, Conte, Dario, Rossi, Giorgio, Penagini, Roberto, Tringali, Andrea (ORCID:0000-0002-9614-3449), Costamagna, Guido (ORCID:0000-0002-8100-2731), Mutignani, Massimiliano (ORCID:0000-0002-1272-4888), Cantu', Paolo, Parzanese, Ilaria, Balassone, Valerio, Di Sario, Antonio, Soggiu, Fiammetta, Lombardi, Giovanni, Barbaro, Federico, Pisani, Antonio, Baldan, Anna, Cariani, Giulio, Boarino, Valentina, Fasoli, Alberto, Bertani, Helga, Forti, Edoardo, Bulajic, Milutin, Ghinolfi, Davide, Nadal, Elena, Cerofolini, Angelo, Barresi, Luca, Catalano, Giorgia, Stroppa, Italo, Traini, Sara, Mazzaferro, Vincenzo, Cipolletta, Livio, Tringali, Andrea, Costamagna, Guido, Ravelli, Paolo, Bazzoli, Franco, Merighi, Alberto, Parodi, Maria Caterina, Conigliaro, Rita, Mutignani, Massimiliano, Zilli, Maurizio, Filipponi, Franco, Fantin, Alberto, Rodella, Luca, Tarantino, Ilaria, Traina, Mario, Salizzoni, Mauro, Rosa, Roberto, Malinverno, Federica, Invernizzi, Federica, Angelo Manini, Matteo, Donato, Maria Francesca, Colombo, Massimo, Conte, Dario, Rossi, Giorgio, Penagini, Roberto, Tringali, Andrea (ORCID:0000-0002-9614-3449), Costamagna, Guido (ORCID:0000-0002-8100-2731), and Mutignani, Massimiliano (ORCID:0000-0002-1272-4888)

Abstract

Anastomotic stricture (AS) can occur in 10%-30% ofliver transplantation (LT) patients leading to liver dysfunction. Its diagnostic workup does not rely on a standard protocol or any international consensus of experts, thus AS management can considerably differ among centers. This affects the selection of patients after LT for endotherapy and, ultimately, results. Endotherapy is considered the reference standard treatment for AS,(2,3) but approach differs among centers depending on local expertise. The aim of the present retrospective survey was to report both the volume of endoscopic retrograde cholangiopancreatographies (ERCPs) dedicated to duct-to-duct AS treatment and the extent of variability in the management of AS at the Italian units involved in endotherapy of LT patients.

Published
2017

22. Early precut sphincterotomy for difficult biliary access to reduce post-ERCP pancreatitis: a randomized trial

Author

Mariani, Alberto, additional, Di Leo, Milena, additional, Giardullo, Nicola, additional, Giussani, Antonella, additional, Marini, Mario, additional, Buffoli, Federico, additional, Cipolletta, Livio, additional, Radaelli, Franco, additional, Ravelli, Paolo, additional, Lombardi, Giovanni, additional, D’Onofrio, Vittorio, additional, Macchiarelli, Raffaele, additional, Iiritano, Elena, additional, Le Grazie, Marco, additional, Pantaleo, Giuseppe, additional, and Testoni, Pier, additional

Published
2016
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24. Interobserver Agreement on Endoscopic Classification of Oesophageal Varices in Children

Author

D’Antiga, Lorenzo, primary, Betalli, Pietro, additional, De Angelis, Paola, additional, Davenport, Mark, additional, Di Giorgio, Angelo, additional, McKiernan, Patrick J., additional, McLin, Valerie, additional, Ravelli, Paolo, additional, Durmaz, Ozlem, additional, Talbotec, Cecile, additional, Sturm, Ekkehard, additional, Woynarowski, Marek, additional, and Burroughs, Andrew K., additional

Published
2015
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26. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths

Author

Buscarini, Elisabetta, primary, Conte, Dario, additional, Cannizzaro, Renato, additional, Bazzoli, Franco, additional, De Boni, Michele, additional, Delle Fave, Gianfranco, additional, Farinati, Fabio, additional, Ravelli, Paolo, additional, Testoni, Pier Alberto, additional, Lisiero, Manola, additional, Spolaore, Paolo, additional, Actis, Giovanni, additional, Adamo, Salvatore, additional, Amitrano, Lucio, additional, Amuso, Mariano, additional, Ancarani, Ornella, additional, Angelico, Mario, additional, Antonini, Filippo, additional, Badiali, Danilo, additional, Balzano, Antonio, additional, Bardella, Maria Teresa, additional, Barresi, Luca, additional, Bellentani, Stefano, additional, Bellini, Massimo, additional, Benedetti, Antonio, additional, Biagini, Massimiliano, additional, Bianchi, Sabrina, additional, Bianco, Antonietta, additional, Borro, Paolo, additional, Bortoli, Aurora, additional, Bortoluzzi, Francesco, additional, Borzio, Mauro, additional, Boskovski, Ivo, additional, Brosolo, Piero, additional, Brunelli, Eugenio, additional, Brunetto, Maurizia, additional, Buri, Luigi, additional, Burra, Patrizia, additional, Caletti, Giancarlo, additional, Chilovi, Fausto, additional, Cicala, Michele, additional, Ciliberto, Enrico, additional, Cilona, Antonio, additional, Cipolletta, Livio, additional, Claar, Giovanni M., additional, Conigliaro, Rita, additional, Conio, Massimo, additional, Corazziari, Enrico, additional, Costamagna, Guido, additional, Cottone, Mario, additional, Craxì, Antonio, additional, Crotta, Sergio, additional, Cucchiara, Salvatore, additional, Cupella, Francesco, additional, Cuppone, Renato, additional, D’Amico, Gennaro, additional, D’Imperio, Nicola, additional, De Angelis, Claudio, additional, De Pretis, Giovanni, additional, De Stefano, Salvatore, additional, Del Favero, Giuseppe, additional, Del Piano, Mario, additional, Di Cillo, Michele, additional, Di Leo, Alfredo, additional, Di Matteo, Giovanni, additional, Ederle, Andrea, additional, Elli, Luca, additional, Fagiuoli, Stefano, additional, Familiari, Luigi, additional, Familiari, Pietro, additional, Fava, Gianmarco, additional, Federici, Telemaco, additional, Ferrini, Giovanni, additional, Filiberti, Rosa, additional, Fracasso, Pierluigi, additional, Framarin, Luciana, additional, Fregonese, Diego, additional, Frosini, Giorgio, additional, Frulloni, Luca, additional, Fusaroli, Pietro, additional, Gallo, Vincenzo, additional, Gatto, Gianni, additional, Gemme, Carlo, additional, Germanà, Bastianello, additional, Germani, Giacomo, additional, Guardascione, Francesco, additional, Gullotta, Renzo, additional, Hassan, Cesare, additional, Ingrosso, Marcello, additional, Kohn, Anna, additional, Lauri, Adriano, additional, Leandro, Gioacchino, additional, Leo, Piero, additional, Lorenzini, Ivano, additional, Loriga, Piero, additional, Macarri, Giampiero, additional, Magnolfi, Fabrizio, additional, Manta, Raffaele, additional, Marchi, Santino, additional, Marin, Renato, additional, Marini, Mario, additional, Marino, Antonino, additional, Meroni, Emanuele, additional, Milazzo, Giuseppe, additional, Monastra, Santo, additional, Montalbano, Luigi, additional, Morini, Sergio, additional, Muscatiello, Nicola, additional, Natali, Alessandro, additional, Neri, Matteo, additional, Nucci, Andrea, additional, Pace, Fabio, additional, Pallone, Francesco, additional, Parodi, Maria Caterina, additional, Pasquale, Luigi, additional, Penagini, Roberto, additional, Peralta, Sergio, additional, Peruzzi, Egiziano, additional, Piazzi, Lucia, additional, Quondamcarlo, Cinzia, additional, Radaelli, Franco, additional, Rendina, Maria, additional, Ridolfi, Francesco, additional, Rosina, Floriano, additional, Salmi, Andrea, additional, Sansoè, Giovanni, additional, Scafato, Emanuele, additional, Scarpulla, Giuseppe, additional, Solinas, Attilio, additional, Soncini, Marco, additional, Sorrentini, Italo, additional, Spinzi, Giancarlo, additional, Stroppa, Italo, additional, Sturniolo, Giancarlo, additional, Sumberaz, Alessandro, additional, Tammaro, Leonardo, additional, Tarantino, Ilaria, additional, Testino, Gianni, additional, Traina, Mario, additional, Triossi, Omero, additional, Usai-Satta, Paolo, additional, Vilardo, Luigi, additional, Virgilio, Clara, additional, Zambelli, Alessandro, additional, Zilli, Maurizio, additional, and Zullo, Angelo, additional

Published
2014
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27. Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: a consensus document from Italian cardiological, surgical and anaesthesiological societies

Author

Rossini, Roberta, primary, Musumeci, Giuseppe, additional, Visconti, Luigi Oltrona, additional, Bramucci, Ezio, additional, Castiglioni, Battistina, additional, De Servi, Stefano, additional, Lettieri, Corrado, additional, Lettino, Maddalena, additional, Piccaluga, Emanuela, additional, Savonitto, Stefano, additional, Trabattoni, Daniela, additional, Capodanno, Davide, additional, Buffoli, Francesca, additional, Parolari, Alessandro, additional, Dionigi, Gianlorenzo, additional, Boni, Luigi, additional, Biglioli, Federico, additional, Valdatta, Luigi, additional, Droghetti, Andrea, additional, Bozzani, Antonio, additional, Setacci, Carlo, additional, Ravelli, Paolo, additional, Crescini, Claudio, additional, Staurenghi, Giovanni, additional, Scarone, Pietro, additional, Francetti, Luca, additional, D’Angelo, Fabio, additional, Gadda, Franco, additional, Comel, Andrea, additional, Salvi, Luca, additional, Lorini, Luca, additional, Antonelli, Massimo, additional, Bovenzi, Francesco, additional, Cremonesi, Alberto, additional, Angiolillo, Dominick J., additional, and Guagliumi, Giulio, additional

Published
2014
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29. Risk factors for Barrett's esophagus: A case-control study

Author

Conio, Massimo, Filiberti, Rosangela, Blanchi, Sabrina, Ferraris, Roberto, Marchi, Santino, Ravelli, Paolo, Lapertosa, Gabriella, Iaquinto, Gaetano, Sablich, Renato, Gusmaroli, Riccardo, Aste, Hugo, Giacosa, Attilio, Conio, M., Munizzi, F., Aste, H., Giacosa, A., Ferraris, R., Fracchia, M., Pera, A., Marchi, S., Costa, F., Rivelli, P., Missale, Guido, Cestari, Renzo, Lapertosa, G., Fiocca, R., D'Onofrio, V., Iaquinto, G., Sablich, R., Lacchin, T., Benedetti, G., and Gusmaroli, R.

Subjects
Adult, Male, medicine.medical_specialty, Cancer Research, Adolescent, GOSPE, Gastroenterology, Hiatal hernia, Barrett Esophagus, Barrett's esophagus, Esophagitis, GERD, Italy, Risk factors, Oncology, Internal medicine, Surveys and Questionnaires, Odds Ratio, Medicine, Humans, Medical history, Risk factor, Aged, Aged, 80 and over, business.industry, Esophageal disease, Incidence, Heartburn, Middle Aged, medicine.disease, humanities, digestive system diseases, Case-Control Studies, Quality of Life, Female, Esophagoscopy, medicine.symptom, business
Abstract

Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case-control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life-style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non-neoplastic, non-gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I–III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio-economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p

Published
2002

32. Su1549 Endoscopic Resection for Sessile and Flat Colorectal Lesions Between High-Volume and Low Volumes Centers in the North of Italy. A Prospective Multicenter Study

Author

Viale, Edi, primary, Notaristefano, Chiara, additional, Masci, Enzo, additional, Fiori, Giancarla, additional, Dinelli, Marco E., additional, Alvisi, Costanza, additional, Manfredi, Guido, additional, Terruzzi, Vittorio, additional, Grasso, Gianalberto, additional, Ravelli, Paolo, additional, Manes, Gianpiero, additional, Giustina, Fabrizio Della, additional, Lochis, Davide, additional, Beretta, Paolo, additional, and Testoni, Pier Alberto, additional

Published
2011
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33. Enteral Self-expandable Metal Stent for Malignant Luminal Obstruction of the Upper and Lower Gastrointestinal Tract

Author

Masci, Enzo, primary, Viale, Edi, additional, Mangiavillano, Benedetto, additional, Contin, Guglielmo, additional, Lomazzi, Alfredo, additional, Buffoli, Federico, additional, Gatti, Mario, additional, Repaci, Giuseppe, additional, Teruzzi, Vittorio, additional, Fasoli, Renato, additional, Ravelli, Paolo, additional, and Testoni, Pier Alberto, additional

Published
2008
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34. Exocrine Pancreatic Cancer, Cigarette Smoking, and Diabetes Mellitus: A Case-Control Study in Northern Italy

Author

Bonelli, Luigina, primary, Aste, Hugo, additional, Bovo, Paolo, additional, Cavallini, Giorgio, additional, Felder, Martina, additional, Gusmaroli, Riccardo, additional, Morandini, Erminio, additional, Ravelli, Paolo, additional, Briglia, Romolo, additional, Lombardo, Lucio, additional, De Micheli, Alberto, additional, and Pugliese, Vittorio, additional

Published
2003
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35. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths.

Author

Conte, Dario, Cannizzaro, Renato, Bazzoli, Franco, De Boni, Michele, Delle Fave, Gianfranco, Farinati, Fabio, Ravelli, Paolo, Testoni, Pier Alberto, Lisiero, Manola, and Spolaore, Paolo

Abstract

In 2011 the three major Italian gastroenterological scientific societies (AIGO, the Italian Society of Hospital Gastroenterologists and Endoscopists; SIED, the Italian Society of Endoscopy; SIGE, the Italian Society of Gastroenterology) prepared their official document aimed at analysing medical care for digestive diseases in Italy, on the basis of national and regional data (Health Ministry and Lombardia, Veneto, Emilia-Romagna databases) and to make proposals for planning of care. Digestive diseases were the first or second cause of hospitalizations in Italy in 1999-2009, with more than 1,500,000 admissions/year; however only 5-9% of these admissions was in specialized Gastroenterology units. Reported data show a better outcome in Gastroenterology Units than in non-specialized units: shorter average length of stay, in particular for admissions with ICD-9-CM codes proxying for emergency conditions (6.7 days versus 8.4 days); better case mix (higher average diagnosis-related groups weight in Gastroenterology Units: 1 vs 0.97 in Internal Medicine units and 0.76 in Surgery units); lower inappropriateness of admissions (16-25% versus 29-87%); lower in-hospital mortality in urgent admissions (2.2% versus 5.1%); for patients with urgent admissions due to gastrointestinnal haemorrhage, in-hospital mortality was 2.3% in Gastroenterology units versus 4.0% in others. The present document summarizes the scientific societies' official report, which constitutes the "White paper of Italian Gastroenterology". [ABSTRACT FROM AUTHOR]

Published
2014
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36. Interobserver Agreement on Endoscopic Classification of Oesophageal Varices in Children

Author

D'Antiga, Lorenzo, Betalli, Pietro, De Angelis, Paola, Davenport, Mark, Di Giorgio, Angelo, McKiernan, Patrick J., McLin, Valerie, Ravelli, Paolo, Durmaz, Ozlem, Talbotec, Cecile, Sturm, Ekkehard, Woynarowski, Marek, and Burroughs, Andrew K.

Abstract

Data regarding agreement on endoscopic features of oesophageal varices in children with portal hypertension (PH) are scant. The aim of this study was to evaluate endoscopic visualisation and classification of oesophageal varices in children by several European clinicians, to build a rational basis for future multicentre trials. Endoscopic pictures of the distal oesophagus of 100 children with a clinical diagnosis of PH were distributed to 10 endoscopists. Observers were requested to classify variceal size according to a 3‐degree scale (small, medium, and large, class A), a 2‐degree scale (small and large, class B), and to recognise red wales (presence or absence, class Red). Overall agreement was considered fair if Fleiss and Cohen κ test was ≥0.30, good if ≥0.40, excellent if ≥0.60, and perfect if ≥0.80. Agreement between observers was fair with class A (κ = 0.34) and class B (κ = 0.38), and good with class Red (κ = 0.49). The agreement was good on presence versus absence of varices (class A = 0.53, class B = 0.48). The agreement among the observers was good in class A when endoscopic features of severe PH (medium and large sizes, red marks) were grouped and compared with mild features (absent and small varices) (κ = 0.58). Experts working in different centres show a fairly good agreement on endoscopic features of PH in children, although a better training of paediatric endoscopists may improve the agreement in grading severity of varices in this setting.

Published
2015
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38. Management of biliary anastomotic strictures after liver transplantation (BASALT study): A nationwide Italian survey

Author

Roberto Penagini, Rita Conigliaro, Mauro Salizzoni, Dario Conte, Maria Francesca Donato, Federico Barbaro, Giorgia Catalano, Giovanni Lombardi, Davide Ghinolfi, Helga Bertani, Guido Costamagna, Livio Cipolletta, Elena Nadal, Roberto Rosa, Antonio Pisani, Antonio Di Sario, Andrea Tringali, Luca Rodella, Massimo Colombo, Massimiliano Mutignani, Milutin Bulajic, Ilaria Parzanese, Valentina Boarino, Angelo Cerofolini, Matteo Angelo Manini, Federica Malinverno, Giulio Cariani, Franco Filipponi, Luca Barresi, Edoardo Forti, Alberto Fasoli, Franco Bazzoli, Ilaria Tarantino, Sara Traini, Vincenzo Mazzaferro, Valerio Balassone, Mario Traina, Alberto Fantin, Paolo Cantù, Fiammetta Soggiu, Giorgio Rossi, Italo Stroppa, Maurizio Zilli, Federica Invernizzi, Alberto Merighi, Maria Caterina Parodi, Paolo Ravelli, Anna Baldan, Cantù, Paolo, Parzanese, Ilaria, Balassone, Valerio, Di Sario, Antonio, Soggiu, Fiammetta, Lombardi, Giovanni, Barbaro, Federico, Pisani, Antonio, Baldan, Anna, Cariani, Giulio, Boarino, Valentina, Fasoli, Alberto, Bertani, Helga, Forti, Edoardo, Bulajic, Milutin, Ghinolfi, Davide, Nadal, Elena, Cerofolini, Angelo, Barresi, Luca, Catalano, Giorgia, Stroppa, Italo, Traini, Sara, Mazzaferro, Vincenzo, Cipolletta, Livio, Tringali, Andrea, Costamagna, Guido, Ravelli, Paolo, Bazzoli, Franco, Merighi, Alberto, Parodi, Maria Caterina, Conigliaro, Rita, Mutignani, Massimiliano, Zilli, Maurizio, Filipponi, Franco, Fantin, Alberto, Rodella, Luca, Tarantino, Ilaria, Traina, Mario, Salizzoni, Mauro, Rosa, Roberto, Malinverno, Federica, Invernizzi, Federica, Angelo Manini, Matteo, Donato, Maria Francesca, Colombo, Massimo, Conte, Dario, Rossi, Giorgio, and Penagini, Roberto

Subjects
medicine.medical_specialty, Settore MED/12 - GASTROENTEROLOGIA, medicine.medical_treatment, Treatment outcome, Constriction, Pathologic, 030230 surgery, Anastomosis, Liver transplantation, Follow-Up Studie, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Surgery, Hepatology, Transplantation, Retrospective Studie, Internal medicine, Surveys and Questionnaires, medicine, Stent, Humans, Surveys and Questionnaire, Retrospective Studies, Cholangiopancreatography, Endoscopic Retrograde, Cholestasis, business.industry, Patient Selection, Follow up studies, biliary anastomotic strictures, Bile Duct, Retrospective cohort study, Liver Transplantation, Treatment Outcome, Multicenter study, Italy, Cholestasi, 030211 gastroenterology & hepatology, Stents, Bile Ducts, Postoperative Complication, business, Hospitals, High-Volume, Magnetic Resonance Angiography, Follow-Up Studies, Human
Abstract

n/a

Published
2017

39. Migration rate using fully covered metal stent in anastomotic strictures after liver transplantation: Results from the BASALT study group.

Author

Conigliaro R, Pigò F, Bertani H, Greco S, Burti C, Indriolo A, Di Sario A, Ortolani A, Maroni L, Tringali A, Barbaro F, Costamagna G, Magarotto A, Masci E, Mutignani M, Forti E, Tringali A, Parodi MC, Assandri L, Marrone C, Fantin A, Penagini R, Cantù P, Di Benedetto F, Ravelli P, Vivarelli M, Agnes S, Mazzaferro V, De Carlis L, Andorno E, Cillo U, and Rossi G

Subjects
Cholangiopancreatography, Endoscopic Retrograde adverse effects, Constriction, Pathologic surgery, Humans, Male, Middle Aged, Plastics, Retrospective Studies, Silicates, Stents adverse effects, Treatment Outcome, Cholestasis etiology, Cholestasis surgery, Liver Transplantation adverse effects
Abstract

Background and Study Aim: The traditional endoscopic therapy of anastomotic strictures (AS) after orthotopic liver transplantation (OLT) is multiple ERCPs with the insertion of an increasing number of plastic stents side-by-side. Fully covered self-expanding metal stents (cSEMS) could be a valuable option to decrease the number of procedures needed or non-responders to plastic stents. This study aims to retrospectively analyse the results of AS endoscopic treatment by cSEMS and to identify any factors associated with its success., Patients and Methods: Ninety-one patients (mean age 55.9 ± 7.6 SD; 73 males) from nine Italian transplantation centres, had a cSEMS positioned for post-OLT-AS between 2007 and 2017. Forty-nine (54%) patients were treated with cSEMS as a second-line treatment., Results: All the procedures were successfully performed without immediate complications. After ERCP, adverse events occurred in 11% of cases (2 moderate pancreatitis and 8 cholangitis). In 49 patients (54%), cSEMSs migrated. After cSEMS removal, 46 patients (51%) needed further endoscopic (45 patients) or radiological (1 patient) treatments to solve the AS. Lastly, seven patients underwent surgery. Multivariable stepwise logistic regression showed that cSEMS migration was the only factor associated with further treatments (OR 2.6, 95% CI 1.0-6.6; p value 0.03); cSEMS implantation before 12 months from OLT was associated with stent migration (OR 5.2, 95% CI 1.7-16.0; p value 0.004)., Conclusions: cSEMS appears to be a safe tool to treat AS. cSEMS migration is the main limitation to its routinary implantation and needs to be prevented, probably with the use of new generation anti-migration stents., (© 2022 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)

Published
2022
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40. Clinical management of inflammatory bowel disease in the organ recipient.

Author

Indriolo A and Ravelli P

Subjects
Azathioprine therapeutic use, Cholangitis, Sclerosing complications, Cholangitis, Sclerosing therapy, Colectomy adverse effects, Colorectal Neoplasms complications, Colorectal Neoplasms therapy, Graft Rejection prevention & control, Humans, Inflammatory Bowel Diseases complications, Kidney Transplantation adverse effects, Mesalamine therapeutic use, Risk Factors, Tacrolimus therapeutic use, Treatment Outcome, Tumor Necrosis Factor-alpha antagonists & inhibitors, End Stage Liver Disease complications, End Stage Liver Disease therapy, Heart Transplantation adverse effects, Inflammatory Bowel Diseases therapy, Liver Transplantation adverse effects
Abstract

There was estimated a higher incidence of de novo inflammatory bowel disease (IBD) after solid organ transplantation than in the general population. The onset of IBD in the organ transplant recipient population is an important clinical situation which is associated to higher morbidity and difficulty in the medical therapeutic management because of possible interaction between anti-reject therapy and IBD therapy. IBD course after liver transplantation (LT) is variable, but about one third of patients may worsen, needing an increase in medical therapy or a colectomy. Active IBD at the time of LT, discontinuation of 5-aminosalicylic acid or azathioprine at the time of LT and use of tacrolimus-based immunosuppression may be associated with an unfavorable outcome of IBD after LT. Anti-tumor necrosis factor alpha (TNFα) therapy for refractory IBD may be an effective and safe therapeutic option after LT. The little experience of the use of biological therapy in transplanted patients, with concomitant anti-rejection therapy, suggests there be a higher more careful surveillance regarding the risk of infectious diseases, autoimmune diseases, and neoplasms. An increased risk of colorectal cancer (CRC) is present also after LT in IBD patients with primary sclerosing cholangitis (PSC). An annual program of endoscopic surveillance with serial biopsies for CRC is recommended. A prophylactic colectomy in selected IBD/PSC patients with CRC risk factors could be a good management strategy in the CRC prevention, but it is used infrequently in the majority of LT centers. About 30% of patients develop multiple IBD recurrence and 20% of patients require a colectomy after renal transplantation. Like in the liver transplantation, anti-TNFα therapy could be an effective treatment in IBD patients with conventional refractory therapy after renal or heart transplantation. A large number of patients are needed to confirm the preliminary observations. Regarding the higher clinical complexity of this subgroup of IBD patients, a close multidisciplinary approach between an IBD dedicated gastroenterologist and surgeon and an organ transplantation specialist is necessary in order to have the best clinical management of IBD after transplantation.

Published
2014
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41. Risk factors for Barrett's esophagus: a case-control study.

Author

Conio M, Filiberti R, Blanchi S, Ferraris R, Marchi S, Ravelli P, Lapertosa G, Iaquinto G, Sablich R, Gusmaroli R, Aste H, and Giacosa A

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Esophagoscopy, Female, Humans, Incidence, Italy epidemiology, Male, Middle Aged, Odds Ratio, Quality of Life, Risk Factors, Surveys and Questionnaires, Barrett Esophagus epidemiology
Abstract

Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case-control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life-style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non-neoplastic, non-gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I-III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio-economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p<0.0001), such as the presence of hiatal hernia (p< or =0.001). Ulcer was significantly associated with BE (p=0.001). Among patients with E, the risk was directly related to spirits consumption (p=0.03). Patients with GERD symptoms that lasted more than 13 years were more likely to have BE than E (p=0.01). In conclusion, results from our study point out that long-standing GERD symptoms, hiatal hernia and possibly alcohol consumption are risk factors in the development of the BE and E., (Copyright 2002 Wiley-Liss, Inc.)

Published
2002
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