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1. Induction of neutralizing antibodies against SARS-CoV-2 variants by a multivalent mRNA-lipid nanoparticle vaccine encoding SARS-CoV-2/SARS-CoV Spike protein receptor-binding domains in mice.

Author

Zhang, Qiong, Tiwari, Shashi, Wen, Jing, Wang, Shaobo, Wang, Lingling, Li, Wanyu, Zhang, Lingzhi, Rawling, Stephen, Cheng, Yong, Jokerst, Jesse, and Rana, Tariq M.

Subjects
SARS-CoV-2, PROTEIN domains, NANOPARTICLES, SARS-CoV-2 Delta variant, ANTIBODY formation, IMMUNOGLOBULINS
Abstract

To address the need for multivalent vaccines against Coronaviridae that can be rapidly developed and manufactured, we compared antibody responses against SARS-CoV, SARS-CoV-2, and several variants of concern in mice immunized with mRNA-lipid nanoparticle vaccines encoding homodimers or heterodimers of SARS-CoV/SARS-CoV-2 receptor-binding domains. All vaccine constructs induced robust anti-RBD antibody responses, and the heterodimeric vaccine elicited an IgG response capable of cross-neutralizing SARS-CoV, SARS-CoV-2 Wuhan-Hu-1, B.1.351 (beta), and B.1.617.2 (delta) variants. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Is pot worse than dope and how bad is that?

Author

Rawling, Stephen

Subjects
Cannabis -- Social aspects, Drugs and youth, Business, Business, international, Retail industry
Abstract

Lifeline is a drug advice agency in Manchester which receives many enquiries from parents, so it has produced a leaflet: 'Everything you wanted to know about cannabis but were afraid to ask your kids: an insider's guide.' It gives clear facts and uses the same cartoon character, Peanut Pete, who appears in guides for drug users themselves. Official drug advice pamphlets tend to discuss several kinds of drugs at once, confusing the reader.

Published
1992

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