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2. PAH Emission in Powerful High-Redshift Radio Galaxies

Author

Rawlings, Jason Ian, Seymour, Nicholas, Page, Mathew, De Breuck, Carlos, Stern, Daniel, Symeonidis, Myrto, Appleton, Phil, Dey, Arjun, Dickinson, Mark, Huynh, Minh, Floc'h, Emeric Le, Lehnert, Matt, Mullaney, James, Nesvadba, Nicole, Ogle, Patrick, Sajina, Anna, Vernet, Joel, and Zirm, Andrew

Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

We present the mid-infrared spectra of seven of the most powerful radio-galaxies known to exist at 1.5 < z < 2.6. The radio emission of these sources is dominated by the AGN with 500 MHz luminosities in the range 10^27.8 - 10^29.1 W/Hz. The AGN signature is clearly evident in the mid-infrared spectra, however, we also detect polycyclic aromatic hydrocarbons emission, indicative of prodigious star formation at a rate of up to ~1000 Msun/yr. Interestingly, we observe no significant correlation between AGN power and star formation in the host galaxy. We also find most of these radio galaxies to have weak 9.7 um silicate absorption features (tau_{9.7 um} < 0.8) which implies that their mid-IR obscuration is predominantly due to the dusty torus that surrounds the central engine, rather than the host galaxy. The tori are likely to have an inhomogeneous distribution with the obscuring structure consisting of individual clouds. We estimate that these radio galaxies have already formed the bulk of their stellar mass and appear to lie at a stage in their evolution where the obscured AGN dominates the energy output of the system but star formation is also prevalent., Comment: 16 pages, 7 figures, accepted for publication in MNRAS

Published
2012

3. The Herschel-SPIRE Legacy Survey (HSLS): the scientific goals of a shallow and wide submillimeter imaging survey with SPIRE

Author

Cooray, Asantha, Eales, Steve, Chapman, Scott, Clements, David L., Dore, Olivier, Farrah, Duncan, Jarvis, Matt J., Kaplinghat, Manoj, Negrello, Mattia, Melchiorri, Alessandro, Peiris, Hiranya, Pope, Alexandra, Santos, Mario G., Serjeant, Stephen, Thompson, Mark, White, Glenn, Amblard, Alexandre, Banerji, Manda, Corasaniti, Pier-Stefano, Das, Sudeep, de_Bernardis, Francesco, de_Zotti, Gianfranco, Giannantonio, Tommaso, Gonzalez, Joaquin Gonzalez-Nuevo, Khostovan, Ali Ahmad, Mitchell-Wynne, Ketron, Serra, Paolo, Song, Yong-Seon, Vieira, Joaquin, Wang, Lingyu, Zemcov, Michael, Abdalla, Filipe, Afonso, Jose, Aghanim, Nabila, Andreani, Paola, Aretxaga, Itziar, Auld, Robbie, Baes, Maarten, Baker, Andrew, Barkats, Denis, Barreiro, R. Belen, Bartolo, Nicola, Barton, Elizabeth, Barway, Sudhanshu, Battistelli, Elia Stefano, Baugh, Carlton, Beelen, Alexander, Benabed, Karim, Blain, Andrew, Bland-Hawthorn, Joss, Bock, James~J., Bond, J. Richard, Borrill, Julian, Borys, Colin, Boselli, Alessandro, Bouchet, Francois R., Bridge, Carrie, Brighenti, Fabrizio, Buat, Veronique, Buote, David, Burgarella, Denis, Bussmann, Robert, Calabrese, Erminia, Cantalupo, Christopher, Carlberg, Raymond, Carvalho, Carla Sofia, Casey, Caitlin, Cava, Antonio, Cepa, Jordi, Chapin, Edward, Chary, Ranga Ram, Chen, Xuelei, Colafrancesco, Sergio, Cole, Shaun, Coles, Peter, Conley, Alexander, Conversi, Luca, Cooke, Jeff, Crawford, Steven, Cress, Catherine, da Cunha, Elisabete, Dalton, Gavin, Danese, Luigi, Dannerbauer, Helmut, Davies, Jonathan, de Bernardis, Paolo, de Putter, Roland, Devlin, Mark, Diego, Jose M., Dole, Herve, Douspis, Marian, Dunkley, Joanna, Dunlop, James, Dunne, Loretta, Dunner, Rolando, Dye, Simon, Efstathiou, George, Egami, Eiichi, Fang, Taotao, Ferrero, Patrizia, Franceschini, Alberto, Frazer, Christopher C., Frayer, David, Frenk, Carlos, Ganga, Ken, Gavazzi, Raphael, Glenn, Jason, Gong, Yan, Gonzalez-Solares, Eduardo, Griffin, Matt, Guo, Qi, Gurwell, Mark, Hajian, Amir, Halpern, Mark, Hanson, Duncan, Hardcastle, Martin, Hatziminaoglou, Evanthia, Heavens, Alan, Heinis, Sebastien, Herranz, Diego, Hilton, Matt, Ho, Shirley, Holwerda, Benne W., Hopwood, Rosalind, Horner, Jonathan, Huffenberger, Kevin, Hughes, David H., Hughes, John P., Ibar, Edo, Ivison, Rob, Jackson, Neal, Jaffe, Andrew, Jenness, Timothy, Joncas, Gilles, Joudaki, Shahab, Kaviraj, Sugata, Kim, Sam, King, Lindsay, Kisner, Theodore, Knapen, Johan, Kniazev, Alexei, Komatsu, Eiichiro, Koopmans, Leon, Kuo, Chao-Lin, Lacey, Cedric, Lahav, Ofer, Lasenby, Anthony N., Lawrence, Andy, Lee, Myung Gyoon, Leeuw, Lerothodi L., Levenson, Louis R., Lewis, Geraint, Loaring, Nicola, Lopez-Caniego, Marcos, Maddox, Steve, Marriage, Tobias, Marsden, Gaelen, Martinez-Gonzalez, Enrique, Masi, Silvia, Matarrese, Sabino, Mathews, William G., Matsuura, Shuji, McMahon, Richard, Mellier, Yannick, Menanteau, Felipe, Michalowski, Michal~J., Millea, Marius, Mobasher, Bahram, Mohanty, Subhanjoy, Montier, Ludovic, Moodley, Kavilan, Moriarty-Schieven, Gerald H., Mortier, Angela, Munshi, Dipak, Murphy, Eric, Nandra, Kirpal, Natoli, Paolo, Nguyen, Hien, Oliver, Seb, Omont, Alain, Page, Lyman, Page, Mathew, Paladini, Roberta, Pandolfi, Stefania, Pascale, Enzo, Patanchon, Guillaume, Peacock, John, Pearson, Chris, Perez-Fournon, Ismael, Perez-Gonz, Pablo G., Piacentini, Francesco, Pierpaoli, Elena, Pohlen, Michael, Pointecouteau, Etienne, Polenta, Gianluca, Rawlings, Jason, Reese, Erik~D., Rigby, Emma, Rodighiero, Giulia, Romero-Colmenero, Encarni, Roseboom, Isaac, Rowan-Robinson, Michael, Sanchez-Portal, Miguel, Schmidt, Fabian, Schneider, Michael, Schulz, Bernhard, Scott, Douglas, Sedgwick, Chris, Sehgal, Neelima, Seymour, Nick, Sherwin, Blake~D., Short, Jo, Shupe, David, Sievers, Jonathan, Skibba, Ramin, Smidt, Joseph, Smith, Anthony, Smith, Daniel J. B., Smith, Matthew W. L., Spergel, David, Staggs, Suzanne, Stevens, Jason, Switzer, Eric, Takagi, Toshinobu, Takeuchi, Tsutomu, Temi, Pasquale, Trichas, Markos, Trigilio, Corrado, Tugwell, Katherine, Umana, Grazia, Vacca, William, Vaccari, Mattia, Vaisanen, Petri, Valtchanov, Ivan, van der Heyden, Kurt, van der Werf, Paul P., van_Kampen, Eelco, van_Waerbeke, Ludovic, Vegetti, Simona, Veneziani, Marcella, Verde, Licia, Verma, Aprajita, Vielva, Patricio, Viero, Marco P., Vilaro, Baltasar Vila, Wardlow, Julie, Wilson, Grant, Wright, Edward L., Xu, C. Kevin, and Yun, Min S.

Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

A large sub-mm survey with Herschel will enable many exciting science opportunities, especially in an era of wide-field optical and radio surveys and high resolution cosmic microwave background experiments. The Herschel-SPIRE Legacy Survey (HSLS), will lead to imaging data over 4000 sq. degrees at 250, 350, and 500 micron. Major Goals of HSLS are: (a) produce a catalog of 2.5 to 3 million galaxies down to 26, 27 and 33 mJy (50% completeness; 5 sigma confusion noise) at 250, 350 and 500 micron, respectively, in the southern hemisphere (3000 sq. degrees) and in an equatorial strip (1000 sq. degrees), areas which have extensive multi-wavelength coverage and are easily accessible from ALMA. Two thirds of the of the sources are expected to be at z > 1, one third at z > 2 and about a 1000 at z > 5. (b) Remove point source confusion in secondary anisotropy studies with Planck and ground-based CMB data. (c) Find at least 1200 strongly lensed bright sub-mm sources leading to a 2% test of general relativity. (d) Identify 200 proto-cluster regions at z of 2 and perform an unbiased study of the environmental dependence of star formation. (e) Perform an unbiased survey for star formation and dust at high Galactic latitude and make a census of debris disks and dust around AGB stars and white dwarfs., Comment: White paper supplement to the proposal submitted by the HSLS science team to ESA for Herschel open-time programs

Published
2010

11. The Herschel-SPIRE Legacy Survey (HSLS): the scientific goals of a shallow and wide submillimeter imaging survey with SPIRE

Author

Cooray, Asantha, Eales, Steve, Chapman, Scott, Clements, David L., Dore, Olivier, Farrah, Duncan, Jarvis, Matt J., Kaplinghat, Manoj, Negrello, Mattia, Melchiorri, Alessandro, Peiris, Hiranya, Pope, Alexandra, Santos, Mario G., Serjeant, Stephen, Thompson, Mark, White, Glenn, Amblard, Alexandre, Banerji, Manda, Corasaniti, Pier-Stefano, Das, Sudeep, Bernardis, Francesco, Zotti, Gianfranco, Giannantonio, Tommaso, Gonzalez-Nuevo Gonzalez, Joaquin, Khostovan, Ali Ahmad, Mitchell-Wynne, Ketron, Serra, Paolo, Song, Yong-Seon, Vieira, Joaquin, Wang, Lingyu, Zemcov, Michael, Abdalla, Filipe, Afonso, Jose, Aghanim, Nabila, Andreani, Paola, Aretxaga, Itziar, Auld, Robbie, Baes, Maarten, Baker, Andrew, Barkats, Denis, Belen Barreiro, R., Bartolo, Nicola, Barton, Elizabeth, Barway, Sudhanshu, Stefano Battistelli, Elia, Baugh, Carlton, Beelen, Alexander, Benabed, Karim, Blain, Andrew, Bland-Hawthorn, Joss, Bock, James J., Bond, J. Richard, Borrill, Julian, Borys, Colin, Boselli, Alessandro, Bouchet, Francois R., Bridge, Carrie, Brighenti, Fabrizio, Buat, Veronique, Buote, David, Burgarella, Denis, Bussmann, Robert, Calabrese, Erminia, Cantalupo, Christopher, Carlberg, Raymond, Sofia Carvalho, Carla, Caitlin Casey, Cava, Antonio, Cepa, Jordi, Chapin, Edward, Ram Chary, Ranga, Chen, Xuelei, Colafrancesco, Sergio, Cole, Shaun, Coles, Peter, Conley, Alexander, Conversi, Luca, Cooke, Jeff, Crawford, Steven, Cress, Catherine, Da Cunha, Elisabete, Dalton, Gavin, Danese, Luigi, Dannerbauer, Helmut, Davies, Jonathan, Bernardis, Paolo, Putter, Roland, Devlin, Mark, Diego, Jose M., Dole, Herve, Douspis, Marian, Dunkley, Joanna, Dunlop, James, Dunne, Loretta, Dunner, Rolando, Dye, Simon, Efstathiou, George, Egami, Eiichi, Fang, Taotao, Ferrero, Patrizia, Franceschini, Alberto, Frazer, Christopher C., Frayer, David, Frenk, Carlos, Ganga, Ken, Gavazzi, Raphael, Glenn, Jason, Gong, Yan, Gonzalez-Solares, Eduardo, Griffin, Matt, Guo, Qi, Gurwell, Mark, Hajian, Amir, Halpern, Mark, Hanson, Duncan, Hardcastle, Martin, Hatziminaoglou, Evanthia, Heavens, Alan, Heinis, Sebastien, Herranz, Diego, Hilton, Matt, Ho, Shirley, Holwerda, Benne W., Hopwood, Rosalind, Horner, Jonathan, Huffenberger, Kevin, Hughes, David H., Hughes, John P., Ibar, Edo, Ivison, Rob, Jackson, Neal, Jaffe, Andrew, Jenness, Timothy, Joncas, Gilles, Joudaki, Shahab, Kaviraj, Sugata, Kim, Sam, King, Lindsay, Kisner, Theodore, Knapen, Johan, Kniazev, Alexei, Komatsu, Eiichiro, Koopmans, Leon, Kuo, Chao-Lin, Lacey, Cedric, Lahav, Ofer, Lasenby, Anthony N., Lawrence, Andy, Lee, Myung Gyoon, Leeuw, Lerothodi L., Levenson, Louis R., Lewis, Geraint, Loaring, Nicola, Lopez-Caniego, Marcos, Maddox, Steve, Marriage, Tobias, Marsden, Gaelen, Martinez-Gonzalez, Enrique, Masi, Silvia, Matarrese, Sabino, Mathews, William G., Matsuura, Shuji, Mcmahon, Richard, Mellier, Yannick, Menanteau, Felipe, Michalowski, Michal J., Millea, Marius, Mobasher, Bahram, Mohanty, Subhanjoy, Montier, Ludovic, Moodley, Kavilan, Moriarty-Schieven, Gerald H., Mortier, Angela, Munshi, Dipak, Murphy, Eric, Nandra, Kirpal, Natoli, Paolo, Nguyen, Hien, Oliver, Seb, Omont, Alain, Page, Lyman, Page, Mathew, Paladini, Roberta, Pandolfi, Stefania, Pascale, Enzo, Patanchon, Guillaume, Peacock, John, Pearson, Chris, Perez-Fournon, Ismael, Perez-Gonz, Pablo G., Piacentini, Francesco, Pierpaoli, Elena, Pohlen, Michael, Pointecouteau, Etienne, Polenta, Gianluca, Rawlings, Jason, Reese, Erik D., Rigby, Emma, Rodighiero, Giulia, Romero-Colmenero, Encarni, Roseboom, Isaac, Rowan-Robinson, Michael, Sanchez-Portal, Miguel, Schmidt, Fabian, Schneider, Michael, Schulz, Bernhard, Scott, Douglas, Sedgwick, Chris, Sehgal, Neelima, Seymour, Nick, Sherwin, Blake D., Short, Jo, Shupe, David, Sievers, Jonathan, Skibba, Ramin, Smidt, Joseph, Smith, Anthony, Smith, Daniel J. B., Smith, Matthew W. L., Spergel, David, Staggs, Suzanne, Stevens, Jason, Switzer, Eric, Takagi, Toshinobu, Takeuchi, Tsutomu, Temi, Pasquale, Trichas, Markos, Trigilio, Corrado, Tugwell, Katherine, Umana, Grazia, Vacca, William, Vaccari, Mattia, Vaisanen, Petri, Valtchanov, Ivan, Heyden, Kurt, Werf, Paul P., Kampen, Eelco, Waerbeke, Ludovic, Vegetti, Simona, Veneziani, Marcella, Verde, Licia, Verma, Aprajita, Vielva, Patricio, Viero, Marco P., Vila Vilaro, Baltasar, Wardlow, Julie, Wilson, Grant, Wright, Edward L., Xu, C. Kevin, Yun, Min S., Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], Cosmology and Nongalactic Astrophysics (astro-ph.CO), FOS: Physical sciences, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

A large sub-mm survey with Herschel will enable many exciting science opportunities, especially in an era of wide-field optical and radio surveys and high resolution cosmic microwave background experiments. The Herschel-SPIRE Legacy Survey (HSLS), will lead to imaging data over 4000 sq. degrees at 250, 350, and 500 micron. Major Goals of HSLS are: (a) produce a catalog of 2.5 to 3 million galaxies down to 26, 27 and 33 mJy (50% completeness; 5 sigma confusion noise) at 250, 350 and 500 micron, respectively, in the southern hemisphere (3000 sq. degrees) and in an equatorial strip (1000 sq. degrees), areas which have extensive multi-wavelength coverage and are easily accessible from ALMA. Two thirds of the of the sources are expected to be at z > 1, one third at z > 2 and about a 1000 at z > 5. (b) Remove point source confusion in secondary anisotropy studies with Planck and ground-based CMB data. (c) Find at least 1200 strongly lensed bright sub-mm sources leading to a 2% test of general relativity. (d) Identify 200 proto-cluster regions at z of 2 and perform an unbiased study of the environmental dependence of star formation. (e) Perform an unbiased survey for star formation and dust at high Galactic latitude and make a census of debris disks and dust around AGB stars and white dwarfs., White paper supplement to the proposal submitted by the HSLS science team to ESA for Herschel open-time programs

Published
2020

14. Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities

Author

Xi Rongwen, Harrison Susan MW, Rennebeck Gabriela, Rawlings Jason S, and Harrison Douglas A

Subjects
Cytology, QH573-671
Abstract

Abstract Background The Janus kinase (JAK) cascade is an essential and well-conserved pathway required to transduce signals for a variety of ligands in both vertebrates and invertebrates. While activation of the pathway is essential to many processes, mutations from mammals and Drosophila demonstrate that regulation is also critical. The SOCS (Suppressor Of Cytokine Signaling) proteins in mammals are regulators of the JAK pathway that participate in a negative feedback loop, as they are transcriptionally activated by JAK signaling. Examination of one Drosophila SOCS homologue, Socs36E, demonstrated that its expression is responsive to JAK pathway activity and it is capable of downregulating JAK signaling, similar to the well characterized mammalian SOCS. Results Based on sequence analysis of the Drosophila genome, there are three identifiable SOCS homologues in flies. All three are most similar to mammalian SOCS that have not been extensively characterized: Socs36E is most similar to mammalian SOCS5, while Socs44A and Socs16D are most similar to mammalian SOCS6 and 7. Although Socs44A is capable of repressing JAK activity in some tissues, its expression is not regulated by the pathway. Furthermore, Socs44A can enhance the activity of the EGFR/MAPK signaling cascade, in contrast to Socs36E. Conclusions Two Drosophila SOCS proteins have some overlapping and some distinct capabilities. While Socs36E behaves similarly to the canonical vertebrate SOCS, Socs44A is not part of a JAK pathway negative feedback loop. Nonetheless, both SOCS regulate JAK and EGFR signaling pathways, albeit differently. The non-canonical properties of Socs44A may be representative of the class of less characterized vertebrate SOCS with which it shares greatest similarity.

Published
2004
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19. Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence

Author

Rawlings, Jason S, Gatzka, Martina, Thomas, Paul G, and Ihle, James N

Subjects
Adenosine Triphosphatases, DNA-Binding Proteins, Immunity, Cellular, Gene Expression Regulation, T-Lymphocyte Subsets, Multiprotein Complexes, Receptors, Antigen, T-Cell, STAT5 Transcription Factor, Interleukin-2, Chromatin Assembly and Disassembly, Lymphocyte Activation, Article, Cell Proliferation
Abstract

Peripheral T cells respond to the cytokine IL-2 only after priming by T-cell receptor-specific antigens, which is shown to allow DNA binding of IL-2-activated Stat5. Surprisingly, quiescent T cells restrict Stat5 access not by histone or DNA modification, but rather by condensin-mediated chromatin compaction.

Published
2010

21. The Swift UVOT serendipitous source catalogue

Author

Page, Mathew J., primary, Yershov, Vladimir, additional, Breeveld, Alice, additional, Kuin, Paul, additional, Mignani, Roberto, additional, Smith, Philip J, additional, Rawlings, Jason, additional, Oates, Samantha, additional, Siegel, Michael, additional, and Roming, Peter, additional

Published
2015
Full Text
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23. Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities

Author

Rawlings, Jason S, Rennebeck, Gabriela, Harrison, Susan MW, Xi, Rongwen, and Harrison, Douglas A

Subjects
Molecular Sequence Data, Suppressor of Cytokine Signaling Proteins, Oogenesis, Proto-Oncogene Proteins, otorhinolaryngologic diseases, Animals, Drosophila Proteins, Wings, Animal, lcsh:QH573-671, Receptors, Invertebrate Peptide, Genome, lcsh:Cytology, Ovary, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, Protein-Tyrosine Kinases, Up-Regulation, ErbB Receptors, Repressor Proteins, Drosophila melanogaster, Female, Protein Kinases, Research Article, Signal Transduction
Abstract

Background The Janus kinase (JAK) cascade is an essential and well-conserved pathway required to transduce signals for a variety of ligands in both vertebrates and invertebrates. While activation of the pathway is essential to many processes, mutations from mammals and Drosophila demonstrate that regulation is also critical. The SOCS (Suppressor Of Cytokine Signaling) proteins in mammals are regulators of the JAK pathway that participate in a negative feedback loop, as they are transcriptionally activated by JAK signaling. Examination of one Drosophila SOCS homologue, Socs36E, demonstrated that its expression is responsive to JAK pathway activity and it is capable of downregulating JAK signaling, similar to the well characterized mammalian SOCS. Results Based on sequence analysis of the Drosophila genome, there are three identifiable SOCS homologues in flies. All three are most similar to mammalian SOCS that have not been extensively characterized: Socs36E is most similar to mammalian SOCS5, while Socs44A and Socs16D are most similar to mammalian SOCS6 and 7. Although Socs44A is capable of repressing JAK activity in some tissues, its expression is not regulated by the pathway. Furthermore, Socs44A can enhance the activity of the EGFR/MAPK signaling cascade, in contrast to Socs36E. Conclusions Two Drosophila SOCS proteins have some overlapping and some distinct capabilities. While Socs36E behaves similarly to the canonical vertebrate SOCS, Socs44A is not part of a JAK pathway negative feedback loop. Nonetheless, both SOCS regulate JAK and EGFR signaling pathways, albeit differently. The non-canonical properties of Socs44A may be representative of the class of less characterized vertebrate SOCS with which it shares greatest similarity.

Published
2004

27. The Herschel-SPIRE Legacy Survey (HSLS): the scientific goals of a shallow and wide submillimeter imaging survey with SPIRE

Author

Cooray, Asantha, Eales, Steve, Chapman, Scott, Clements, David L., Dore, Olivier, Farrah, Duncan, Jarvis, Matt J., Kaplinghat, Manoj, Negrello, Mattia, Melchiorri, Alessandro, Peiris, Hiranya, Pope, Alexandra, Santos, Mario G., Serjeant, Stephen, Thompson, Mark, White, Glenn, Amblard, Alexandre, Banerji, Manda, Corasaniti, Pier-Stefano, Das, Sudeep, de Bernardis, Francesco, de Zotti, Gianfranco, Giannantonio, Tommaso, Gonzalez-Nuevo Gonzalez, Joaquin, Khostovan, Ali Ahmad, Mitchell-Wynne, Ketron, Serra, Paolo, Song, Yong-Seon, Vieira, Joaquin, Wang, Lingyu, Zemcov, Michael, Abdalla, Filipe, Afonso, Jose, Aghanim, Nabila, Andreani, Paola, Aretxaga, Itziar, Auld, Robbie, Baes, Maarten, Baker, Andrew, Barkats, Denis, Belen Barreiro, R., Bartolo, Nicola, Barton, Elizabeth, Barway, Sudhanshu, Stefano Battistelli, Elia, Baugh, Carlton, Beelen, Alexander, Benabed, Karim, Blain, Andrew, Bland-Hawthorn, Joss, Bock, James~J., Bond, J. Richard, Borrill, Julian, Borys, Colin, Boselli, Alessandro, Bouchet, Francois R., Bridge, Carrie, Brighenti, Fabrizio, Buat, Veronique, Buote, David, Burgarella, Denis, Bussmann, Robert, Calabrese, Erminia, Cantalupo, Christopher, Carlberg, Raymond, Sofia Carvalho, Carla, Casey, Caitlin, Cava, Antonio, Cepa, Jordi, Chapin, Edward, Chary, Ranga Ram, Chen, Xuelei, Colafrancesco, Sergio, Cole, Shaun, Coles, Peter, Conley, Alexander, Conversi, Luca, Cooke, Jeff, Crawford, Steven, Cress, Catherine, da Cunha, Elisabete, Dalton, Gavin, Danese, Luigi, Dannerbauer, Helmut, Davies, Jonathan, de Bernardis, Paolo, de Putter, Roland, Devlin, Mark, Diego, Jose M., Dole, Herve, Douspis, Marian, Dunkley, Joanna, Dunlop, James, Dunne, Loretta, Dunner, Rolando, Dye, Simon, Efstathiou, George, Egami, Eiichi, Fang, Taotao, Ferrero, Patrizia, Franceschini, Alberto, Frazer, Christopher C., Frayer, David, Frenk, Carlos, Ganga, Ken, Gavazzi, Raphael, Glenn, Jason, Gong, Yan, Gonzalez-Solares, Eduardo, Griffin, Matt, Guo, Qi, Gurwell, Mark, Hajian, Amir, Halpern, Mark, Hanson, Duncan, Hardcastle, Martin, Hatziminaoglou, Evanthia, Heavens, Alan, Heinis, Sebastien, Herranz, Diego, Hilton, Matt, Ho, Shirley, Holwerda, Benne W., Hopwood, Rosalind, Horner, Jonathan, Huffenberger, Kevin, Hughes, David H., Hughes, John P., Ibar, Edo, Ivison, Rob, Jackson, Neal, Jaffe, Andrew, Jenness, Timothy, Joncas, Gilles, Joudaki, Shahab, Kaviraj, Sugata, Kim, Sam, King, Lindsay, Kisner, Theodore, Knapen, Johan, Kniazev, Alexei, Komatsu, Eiichiro, Koopmans, Leon, Kuo, Chao-Lin, Lacey, Cedric, Lahav, Ofer, Lasenby, Anthony N., Lawrence, Andy, Lee, Myung Gyoon, Leeuw, Lerothodi L., Levenson, Louis R., Lewis, Geraint, Loaring, Nicola, Lopez-Caniego, Marcos, Maddox, Steve, Marriage, Tobias, Marsden, Gaelen, Martinez-Gonzalez, Enrique, Masi, Silvia, Matarrese, Sabino, Mathews, William G., Matsuura, Shuji, McMahon, Richard, Mellier, Yannick, Menanteau, Felipe, Michalowski, Michal~J., Millea, Marius, Mobasher, Bahram, Mohanty, Subhanjoy, Montier, Ludovic, Moodley, Kavilan, Moriarty-Schieven, Gerald H., Mortier, Angela, Munshi, Dipak, Murphy, Eric, Nandra, Kirpal, Natoli, Paolo, Nguyen, Hien, Oliver, Seb, Omont, Alain, Page, Lyman, Page, Mathew, Paladini, Roberta, Pandolfi, Stefania, Pascale, Enzo, Patanchon, Guillaume, Peacock, John, Pearson, Chris, Perez-Fournon, Ismael, Perez-Gonz, Pablo G., Piacentini, Francesco, Pierpaoli, Elena, Pohlen, Michael, Pointecouteau, Etienne, Polenta, Gianluca, Rawlings, Jason, Reese, Erik~D., Rigby, Emma, Rodighiero, Giulia, Romero-Colmenero, Encarni, Roseboom, Isaac, Rowan-Robinson, Michael, Sanchez-Portal, Miguel, Schmidt, Fabian, Schneider, Michael, Schulz, Bernhard, Scott, Douglas, Sedgwick, Chris, Sehgal, Neelima, Seymour, Nick, Sherwin, Blake~D., Short, Jo, Shupe, David, Sievers, Jonathan, Skibba, Ramin, Smidt, Joseph, Smith, Anthony, Smith, Daniel J. B., Smith, Matthew W. L., Spergel, David, Staggs, Suzanne, Stevens, Jason, Switzer, Eric, Takagi, Toshinobu, Takeuchi, Tsutomu, Temi, Pasquale, Trichas, Markos, Trigilio, Corrado, Tugwell, Katherine, Umana, Grazia, Vacca, William, Vaccari, Mattia, Vaisanen, Petri, Valtchanov, Ivan, van der Heyden, Kurt, van der Werf, Paul P., van Kampen, Eelco, van Waerbeke, Ludovic, Vegetti, Simona, Veneziani, Marcella, Verde, Licia, Verma, Aprajita, Vielva, Patricio, Viero, Marco P., Vila Vilaro, Baltasar, Wardlow, Julie, Wilson, Grant, Wright, Edward L., Xu, C. Kevin, Yun, Min S., Cooray, Asantha, Eales, Steve, Chapman, Scott, Clements, David L., Dore, Olivier, Farrah, Duncan, Jarvis, Matt J., Kaplinghat, Manoj, Negrello, Mattia, Melchiorri, Alessandro, Peiris, Hiranya, Pope, Alexandra, Santos, Mario G., Serjeant, Stephen, Thompson, Mark, White, Glenn, Amblard, Alexandre, Banerji, Manda, Corasaniti, Pier-Stefano, Das, Sudeep, de Bernardis, Francesco, de Zotti, Gianfranco, Giannantonio, Tommaso, Gonzalez-Nuevo Gonzalez, Joaquin, Khostovan, Ali Ahmad, Mitchell-Wynne, Ketron, Serra, Paolo, Song, Yong-Seon, Vieira, Joaquin, Wang, Lingyu, Zemcov, Michael, Abdalla, Filipe, Afonso, Jose, Aghanim, Nabila, Andreani, Paola, Aretxaga, Itziar, Auld, Robbie, Baes, Maarten, Baker, Andrew, Barkats, Denis, Belen Barreiro, R., Bartolo, Nicola, Barton, Elizabeth, Barway, Sudhanshu, Stefano Battistelli, Elia, Baugh, Carlton, Beelen, Alexander, Benabed, Karim, Blain, Andrew, Bland-Hawthorn, Joss, Bock, James~J., Bond, J. Richard, Borrill, Julian, Borys, Colin, Boselli, Alessandro, Bouchet, Francois R., Bridge, Carrie, Brighenti, Fabrizio, Buat, Veronique, Buote, David, Burgarella, Denis, Bussmann, Robert, Calabrese, Erminia, Cantalupo, Christopher, Carlberg, Raymond, Sofia Carvalho, Carla, Casey, Caitlin, Cava, Antonio, Cepa, Jordi, Chapin, Edward, Chary, Ranga Ram, Chen, Xuelei, Colafrancesco, Sergio, Cole, Shaun, Coles, Peter, Conley, Alexander, Conversi, Luca, Cooke, Jeff, Crawford, Steven, Cress, Catherine, da Cunha, Elisabete, Dalton, Gavin, Danese, Luigi, Dannerbauer, Helmut, Davies, Jonathan, de Bernardis, Paolo, de Putter, Roland, Devlin, Mark, Diego, Jose M., Dole, Herve, Douspis, Marian, Dunkley, Joanna, Dunlop, James, Dunne, Loretta, Dunner, Rolando, Dye, Simon, Efstathiou, George, Egami, Eiichi, Fang, Taotao, Ferrero, Patrizia, Franceschini, Alberto, Frazer, Christopher C., Frayer, David, Frenk, Carlos, Ganga, Ken, Gavazzi, Raphael, Glenn, Jason, Gong, Yan, Gonzalez-Solares, Eduardo, Griffin, Matt, Guo, Qi, Gurwell, Mark, Hajian, Amir, Halpern, Mark, Hanson, Duncan, Hardcastle, Martin, Hatziminaoglou, Evanthia, Heavens, Alan, Heinis, Sebastien, Herranz, Diego, Hilton, Matt, Ho, Shirley, Holwerda, Benne W., Hopwood, Rosalind, Horner, Jonathan, Huffenberger, Kevin, Hughes, David H., Hughes, John P., Ibar, Edo, Ivison, Rob, Jackson, Neal, Jaffe, Andrew, Jenness, Timothy, Joncas, Gilles, Joudaki, Shahab, Kaviraj, Sugata, Kim, Sam, King, Lindsay, Kisner, Theodore, Knapen, Johan, Kniazev, Alexei, Komatsu, Eiichiro, Koopmans, Leon, Kuo, Chao-Lin, Lacey, Cedric, Lahav, Ofer, Lasenby, Anthony N., Lawrence, Andy, Lee, Myung Gyoon, Leeuw, Lerothodi L., Levenson, Louis R., Lewis, Geraint, Loaring, Nicola, Lopez-Caniego, Marcos, Maddox, Steve, Marriage, Tobias, Marsden, Gaelen, Martinez-Gonzalez, Enrique, Masi, Silvia, Matarrese, Sabino, Mathews, William G., Matsuura, Shuji, McMahon, Richard, Mellier, Yannick, Menanteau, Felipe, Michalowski, Michal~J., Millea, Marius, Mobasher, Bahram, Mohanty, Subhanjoy, Montier, Ludovic, Moodley, Kavilan, Moriarty-Schieven, Gerald H., Mortier, Angela, Munshi, Dipak, Murphy, Eric, Nandra, Kirpal, Natoli, Paolo, Nguyen, Hien, Oliver, Seb, Omont, Alain, Page, Lyman, Page, Mathew, Paladini, Roberta, Pandolfi, Stefania, Pascale, Enzo, Patanchon, Guillaume, Peacock, John, Pearson, Chris, Perez-Fournon, Ismael, Perez-Gonz, Pablo G., Piacentini, Francesco, Pierpaoli, Elena, Pohlen, Michael, Pointecouteau, Etienne, Polenta, Gianluca, Rawlings, Jason, Reese, Erik~D., Rigby, Emma, Rodighiero, Giulia, Romero-Colmenero, Encarni, Roseboom, Isaac, Rowan-Robinson, Michael, Sanchez-Portal, Miguel, Schmidt, Fabian, Schneider, Michael, Schulz, Bernhard, Scott, Douglas, Sedgwick, Chris, Sehgal, Neelima, Seymour, Nick, Sherwin, Blake~D., Short, Jo, Shupe, David, Sievers, Jonathan, Skibba, Ramin, Smidt, Joseph, Smith, Anthony, Smith, Daniel J. B., Smith, Matthew W. L., Spergel, David, Staggs, Suzanne, Stevens, Jason, Switzer, Eric, Takagi, Toshinobu, Takeuchi, Tsutomu, Temi, Pasquale, Trichas, Markos, Trigilio, Corrado, Tugwell, Katherine, Umana, Grazia, Vacca, William, Vaccari, Mattia, Vaisanen, Petri, Valtchanov, Ivan, van der Heyden, Kurt, van der Werf, Paul P., van Kampen, Eelco, van Waerbeke, Ludovic, Vegetti, Simona, Veneziani, Marcella, Verde, Licia, Verma, Aprajita, Vielva, Patricio, Viero, Marco P., Vila Vilaro, Baltasar, Wardlow, Julie, Wilson, Grant, Wright, Edward L., Xu, C. Kevin, and Yun, Min S.

Abstract

A large sub-mm survey with Herschel will enable many exciting science opportunities, especially in an era of wide-field optical and radio surveys and high resolution cosmic microwave background experiments. The Herschel-SPIRE Legacy Survey (HSLS), will lead to imaging data over 4000 sq. degrees at 250, 350, and 500 micron. Major Goals of HSLS are: (a) produce a catalog of 2.5 to 3 million galaxies down to 26, 27 and 33 mJy (50% completeness; 5 sigma confusion noise) at 250, 350 and 500 micron, respectively, in the southern hemisphere (3000 sq. degrees) and in an equatorial strip (1000 sq. degrees), areas which have extensive multi-wavelength coverage and are easily accessible from ALMA. Two thirds of the of the sources are expected to be at z > 1, one third at z > 2 and about a 1000 at z > 5. (b) Remove point source confusion in secondary anisotropy studies with Planck and ground-based CMB data. (c) Find at least 1200 strongly lensed bright sub-mm sources leading to a 2% test of general relativity. (d) Identify 200 proto-cluster regions at z of 2 and perform an unbiased study of the environmental dependence of star formation. (e) Perform an unbiased survey for star formation and dust at high Galactic latitude and make a census of debris disks and dust around AGB stars and white dwarfs.

28. The Herschel-SPIRE Legacy Survey (HSLS): the scientific goals of a shallow and wide submillimeter imaging survey with SPIRE

Author

Cooray, Asantha, Eales, Steve, Chapman, Scott, Clements, David L., Dore, Olivier, Farrah, Duncan, Jarvis, Matt J., Kaplinghat, Manoj, Negrello, Mattia, Melchiorri, Alessandro, Peiris, Hiranya, Pope, Alexandra, Santos, Mario G., Serjeant, Stephen, Thompson, Mark, White, Glenn, Amblard, Alexandre, Banerji, Manda, Corasaniti, Pier-Stefano, Das, Sudeep, de Bernardis, Francesco, de Zotti, Gianfranco, Giannantonio, Tommaso, Gonzalez-Nuevo Gonzalez, Joaquin, Khostovan, Ali Ahmad, Mitchell-Wynne, Ketron, Serra, Paolo, Song, Yong-Seon, Vieira, Joaquin, Wang, Lingyu, Zemcov, Michael, Abdalla, Filipe, Afonso, Jose, Aghanim, Nabila, Andreani, Paola, Aretxaga, Itziar, Auld, Robbie, Baes, Maarten, Baker, Andrew, Barkats, Denis, Belen Barreiro, R., Bartolo, Nicola, Barton, Elizabeth, Barway, Sudhanshu, Stefano Battistelli, Elia, Baugh, Carlton, Beelen, Alexander, Benabed, Karim, Blain, Andrew, Bland-Hawthorn, Joss, Bock, James~J., Bond, J. Richard, Borrill, Julian, Borys, Colin, Boselli, Alessandro, Bouchet, Francois R., Bridge, Carrie, Brighenti, Fabrizio, Buat, Veronique, Buote, David, Burgarella, Denis, Bussmann, Robert, Calabrese, Erminia, Cantalupo, Christopher, Carlberg, Raymond, Sofia Carvalho, Carla, Casey, Caitlin, Cava, Antonio, Cepa, Jordi, Chapin, Edward, Chary, Ranga Ram, Chen, Xuelei, Colafrancesco, Sergio, Cole, Shaun, Coles, Peter, Conley, Alexander, Conversi, Luca, Cooke, Jeff, Crawford, Steven, Cress, Catherine, da Cunha, Elisabete, Dalton, Gavin, Danese, Luigi, Dannerbauer, Helmut, Davies, Jonathan, de Bernardis, Paolo, de Putter, Roland, Devlin, Mark, Diego, Jose M., Dole, Herve, Douspis, Marian, Dunkley, Joanna, Dunlop, James, Dunne, Loretta, Dunner, Rolando, Dye, Simon, Efstathiou, George, Egami, Eiichi, Fang, Taotao, Ferrero, Patrizia, Franceschini, Alberto, Frazer, Christopher C., Frayer, David, Frenk, Carlos, Ganga, Ken, Gavazzi, Raphael, Glenn, Jason, Gong, Yan, Gonzalez-Solares, Eduardo, Griffin, Matt, Guo, Qi, Gurwell, Mark, Hajian, Amir, Halpern, Mark, Hanson, Duncan, Hardcastle, Martin, Hatziminaoglou, Evanthia, Heavens, Alan, Heinis, Sebastien, Herranz, Diego, Hilton, Matt, Ho, Shirley, Holwerda, Benne W., Hopwood, Rosalind, Horner, Jonathan, Huffenberger, Kevin, Hughes, David H., Hughes, John P., Ibar, Edo, Ivison, Rob, Jackson, Neal, Jaffe, Andrew, Jenness, Timothy, Joncas, Gilles, Joudaki, Shahab, Kaviraj, Sugata, Kim, Sam, King, Lindsay, Kisner, Theodore, Knapen, Johan, Kniazev, Alexei, Komatsu, Eiichiro, Koopmans, Leon, Kuo, Chao-Lin, Lacey, Cedric, Lahav, Ofer, Lasenby, Anthony N., Lawrence, Andy, Lee, Myung Gyoon, Leeuw, Lerothodi L., Levenson, Louis R., Lewis, Geraint, Loaring, Nicola, Lopez-Caniego, Marcos, Maddox, Steve, Marriage, Tobias, Marsden, Gaelen, Martinez-Gonzalez, Enrique, Masi, Silvia, Matarrese, Sabino, Mathews, William G., Matsuura, Shuji, McMahon, Richard, Mellier, Yannick, Menanteau, Felipe, Michalowski, Michal~J., Millea, Marius, Mobasher, Bahram, Mohanty, Subhanjoy, Montier, Ludovic, Moodley, Kavilan, Moriarty-Schieven, Gerald H., Mortier, Angela, Munshi, Dipak, Murphy, Eric, Nandra, Kirpal, Natoli, Paolo, Nguyen, Hien, Oliver, Seb, Omont, Alain, Page, Lyman, Page, Mathew, Paladini, Roberta, Pandolfi, Stefania, Pascale, Enzo, Patanchon, Guillaume, Peacock, John, Pearson, Chris, Perez-Fournon, Ismael, Perez-Gonz, Pablo G., Piacentini, Francesco, Pierpaoli, Elena, Pohlen, Michael, Pointecouteau, Etienne, Polenta, Gianluca, Rawlings, Jason, Reese, Erik~D., Rigby, Emma, Rodighiero, Giulia, Romero-Colmenero, Encarni, Roseboom, Isaac, Rowan-Robinson, Michael, Sanchez-Portal, Miguel, Schmidt, Fabian, Schneider, Michael, Schulz, Bernhard, Scott, Douglas, Sedgwick, Chris, Sehgal, Neelima, Seymour, Nick, Sherwin, Blake~D., Short, Jo, Shupe, David, Sievers, Jonathan, Skibba, Ramin, Smidt, Joseph, Smith, Anthony, Smith, Daniel J. B., Smith, Matthew W. L., Spergel, David, Staggs, Suzanne, Stevens, Jason, Switzer, Eric, Takagi, Toshinobu, Takeuchi, Tsutomu, Temi, Pasquale, Trichas, Markos, Trigilio, Corrado, Tugwell, Katherine, Umana, Grazia, Vacca, William, Vaccari, Mattia, Vaisanen, Petri, Valtchanov, Ivan, van der Heyden, Kurt, van der Werf, Paul P., van Kampen, Eelco, van Waerbeke, Ludovic, Vegetti, Simona, Veneziani, Marcella, Verde, Licia, Verma, Aprajita, Vielva, Patricio, Viero, Marco P., Vila Vilaro, Baltasar, Wardlow, Julie, Wilson, Grant, Wright, Edward L., Xu, C. Kevin, Yun, Min S., Cooray, Asantha, Eales, Steve, Chapman, Scott, Clements, David L., Dore, Olivier, Farrah, Duncan, Jarvis, Matt J., Kaplinghat, Manoj, Negrello, Mattia, Melchiorri, Alessandro, Peiris, Hiranya, Pope, Alexandra, Santos, Mario G., Serjeant, Stephen, Thompson, Mark, White, Glenn, Amblard, Alexandre, Banerji, Manda, Corasaniti, Pier-Stefano, Das, Sudeep, de Bernardis, Francesco, de Zotti, Gianfranco, Giannantonio, Tommaso, Gonzalez-Nuevo Gonzalez, Joaquin, Khostovan, Ali Ahmad, Mitchell-Wynne, Ketron, Serra, Paolo, Song, Yong-Seon, Vieira, Joaquin, Wang, Lingyu, Zemcov, Michael, Abdalla, Filipe, Afonso, Jose, Aghanim, Nabila, Andreani, Paola, Aretxaga, Itziar, Auld, Robbie, Baes, Maarten, Baker, Andrew, Barkats, Denis, Belen Barreiro, R., Bartolo, Nicola, Barton, Elizabeth, Barway, Sudhanshu, Stefano Battistelli, Elia, Baugh, Carlton, Beelen, Alexander, Benabed, Karim, Blain, Andrew, Bland-Hawthorn, Joss, Bock, James~J., Bond, J. Richard, Borrill, Julian, Borys, Colin, Boselli, Alessandro, Bouchet, Francois R., Bridge, Carrie, Brighenti, Fabrizio, Buat, Veronique, Buote, David, Burgarella, Denis, Bussmann, Robert, Calabrese, Erminia, Cantalupo, Christopher, Carlberg, Raymond, Sofia Carvalho, Carla, Casey, Caitlin, Cava, Antonio, Cepa, Jordi, Chapin, Edward, Chary, Ranga Ram, Chen, Xuelei, Colafrancesco, Sergio, Cole, Shaun, Coles, Peter, Conley, Alexander, Conversi, Luca, Cooke, Jeff, Crawford, Steven, Cress, Catherine, da Cunha, Elisabete, Dalton, Gavin, Danese, Luigi, Dannerbauer, Helmut, Davies, Jonathan, de Bernardis, Paolo, de Putter, Roland, Devlin, Mark, Diego, Jose M., Dole, Herve, Douspis, Marian, Dunkley, Joanna, Dunlop, James, Dunne, Loretta, Dunner, Rolando, Dye, Simon, Efstathiou, George, Egami, Eiichi, Fang, Taotao, Ferrero, Patrizia, Franceschini, Alberto, Frazer, Christopher C., Frayer, David, Frenk, Carlos, Ganga, Ken, Gavazzi, Raphael, Glenn, Jason, Gong, Yan, Gonzalez-Solares, Eduardo, Griffin, Matt, Guo, Qi, Gurwell, Mark, Hajian, Amir, Halpern, Mark, Hanson, Duncan, Hardcastle, Martin, Hatziminaoglou, Evanthia, Heavens, Alan, Heinis, Sebastien, Herranz, Diego, Hilton, Matt, Ho, Shirley, Holwerda, Benne W., Hopwood, Rosalind, Horner, Jonathan, Huffenberger, Kevin, Hughes, David H., Hughes, John P., Ibar, Edo, Ivison, Rob, Jackson, Neal, Jaffe, Andrew, Jenness, Timothy, Joncas, Gilles, Joudaki, Shahab, Kaviraj, Sugata, Kim, Sam, King, Lindsay, Kisner, Theodore, Knapen, Johan, Kniazev, Alexei, Komatsu, Eiichiro, Koopmans, Leon, Kuo, Chao-Lin, Lacey, Cedric, Lahav, Ofer, Lasenby, Anthony N., Lawrence, Andy, Lee, Myung Gyoon, Leeuw, Lerothodi L., Levenson, Louis R., Lewis, Geraint, Loaring, Nicola, Lopez-Caniego, Marcos, Maddox, Steve, Marriage, Tobias, Marsden, Gaelen, Martinez-Gonzalez, Enrique, Masi, Silvia, Matarrese, Sabino, Mathews, William G., Matsuura, Shuji, McMahon, Richard, Mellier, Yannick, Menanteau, Felipe, Michalowski, Michal~J., Millea, Marius, Mobasher, Bahram, Mohanty, Subhanjoy, Montier, Ludovic, Moodley, Kavilan, Moriarty-Schieven, Gerald H., Mortier, Angela, Munshi, Dipak, Murphy, Eric, Nandra, Kirpal, Natoli, Paolo, Nguyen, Hien, Oliver, Seb, Omont, Alain, Page, Lyman, Page, Mathew, Paladini, Roberta, Pandolfi, Stefania, Pascale, Enzo, Patanchon, Guillaume, Peacock, John, Pearson, Chris, Perez-Fournon, Ismael, Perez-Gonz, Pablo G., Piacentini, Francesco, Pierpaoli, Elena, Pohlen, Michael, Pointecouteau, Etienne, Polenta, Gianluca, Rawlings, Jason, Reese, Erik~D., Rigby, Emma, Rodighiero, Giulia, Romero-Colmenero, Encarni, Roseboom, Isaac, Rowan-Robinson, Michael, Sanchez-Portal, Miguel, Schmidt, Fabian, Schneider, Michael, Schulz, Bernhard, Scott, Douglas, Sedgwick, Chris, Sehgal, Neelima, Seymour, Nick, Sherwin, Blake~D., Short, Jo, Shupe, David, Sievers, Jonathan, Skibba, Ramin, Smidt, Joseph, Smith, Anthony, Smith, Daniel J. B., Smith, Matthew W. L., Spergel, David, Staggs, Suzanne, Stevens, Jason, Switzer, Eric, Takagi, Toshinobu, Takeuchi, Tsutomu, Temi, Pasquale, Trichas, Markos, Trigilio, Corrado, Tugwell, Katherine, Umana, Grazia, Vacca, William, Vaccari, Mattia, Vaisanen, Petri, Valtchanov, Ivan, van der Heyden, Kurt, van der Werf, Paul P., van Kampen, Eelco, van Waerbeke, Ludovic, Vegetti, Simona, Veneziani, Marcella, Verde, Licia, Verma, Aprajita, Vielva, Patricio, Viero, Marco P., Vila Vilaro, Baltasar, Wardlow, Julie, Wilson, Grant, Wright, Edward L., Xu, C. Kevin, and Yun, Min S.

Abstract

A large sub-mm survey with Herschel will enable many exciting science opportunities, especially in an era of wide-field optical and radio surveys and high resolution cosmic microwave background experiments. The Herschel-SPIRE Legacy Survey (HSLS), will lead to imaging data over 4000 sq. degrees at 250, 350, and 500 micron. Major Goals of HSLS are: (a) produce a catalog of 2.5 to 3 million galaxies down to 26, 27 and 33 mJy (50% completeness; 5 sigma confusion noise) at 250, 350 and 500 micron, respectively, in the southern hemisphere (3000 sq. degrees) and in an equatorial strip (1000 sq. degrees), areas which have extensive multi-wavelength coverage and are easily accessible from ALMA. Two thirds of the of the sources are expected to be at z > 1, one third at z > 2 and about a 1000 at z > 5. (b) Remove point source confusion in secondary anisotropy studies with Planck and ground-based CMB data. (c) Find at least 1200 strongly lensed bright sub-mm sources leading to a 2% test of general relativity. (d) Identify 200 proto-cluster regions at z of 2 and perform an unbiased study of the environmental dependence of star formation. (e) Perform an unbiased survey for star formation and dust at high Galactic latitude and make a census of debris disks and dust around AGB stars and white dwarfs.

29. IDENTIFICATION AND CHARACTERIZATION OF SOCS44A IN DROSOPHILA

Author

Rawlings, Jason Scott

Subjects
JAK/STAT pathway|Suppressors of Cytokine Signaling|regulation of signal transduction|Socs44A|Drosophila development
Abstract

The JAK/STAT pathway is but one of the signal transduction cascades responsible for proper development and homeostasis. Gain-of-function mutations of pathway components are causative agents of several leukemias, highlighting the necessity for proper regulation of signal transduction. Drosophila presents an attractive model to study JAK/STAT signaling because mutations in the pathway behave in an analogous manner. Furthermore, the Drosophila cascade is much simpler as only one of each component required for activation has been characterized; whereas in mammals, there are many ligands, receptors, 4 JAKs and 7 STATs.Suppressors of Cytokine Signaling (SOCS) are one family of molecules which regulate JAK/STAT signaling via a negative feedback loop. All SOCS share a distinct modular domain architecture, which we exploited to locate three putative SOCS homologues within the Drosophila genome. I present the identification and initial characterization of one of these homologues, Socs44A. I show that Socs44A is not responsive to or dependent on JAK activity. However, I demonstrate that Socs44A is capable of downregulating JAK/STAT signaling in the developing wing but not inoogenesis, indicating that its ability to regulate the pathway is tissue specific, a phenomenon observed in the mammalian model.Signal transduction pathways are integrated at multiple levels. This interplay allows for combinatorial signaling, resulting in a higher order of complexity in the signals that can be received and interpreted by a cell. Well documented are the interactions between the JAK/STAT and the EGFR/MAPK pathways. In this work, I show that Socs44A can genetically interact with, and upregulate, the EGFR/MAPK pathway, analogous to a recent report involving SOCS-3.Starting with the Drosophila genome sequence, I initiated a reverse genetic approach to studying the function of the Socs44A locus. During the course of this investigation, I designed and implemented a novel post-processor of the BLAST algorithm, called Multi-BLAST, which facilitates retrieval of multiple domain sequences from public databases. In what would have been the ultimate achievement of this study, I attempted two mutagenesis screens designed to isolate Socs44A loss-of-function alleles. Progress on these screens is reported.

Published
2004

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