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266 results on '"Raymond-Letron, Isabelle"'

1. Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer

Author

Timaxian, Colin, Vogel, Christoph FA, Orcel, Charlotte, Vetter, Diana, Durochat, Camille, Chinal, Clarisse, NGuyen, Phuong, Aknin, Marie-Laure, Mercier-Nomé, Françoise, Davy, Martin, Raymond-Letron, Isabelle, Van, Thi-Nhu-Ngoc, Diermeier, Sarah D, Godefroy, Anastasia, Gary-Bobo, Magali, Molina, Franck, Balabanian, Karl, and Lazennec, Gwendal

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Breast Cancer, Aetiology, 2.1 Biological and endogenous factors, chemokine receptors, breast cancer, Cxcr2, neutrophils, tumor microenvironment, Oncology and carcinogenesis
Abstract

Chemokines present in the tumor microenvironment are essential for the control of tumor progression. We show here that several ligands of the chemokine receptor Cxcr2 were up-regulated in the PyMT (polyoma middle T oncogene) model of breast cancer. Interestingly, the knock-down of Cxcr2 in PyMT animals led to an increased growth of the primary tumor and lung metastasis. The analysis of tumor content of PyMT-Cxcr2-/- animals highlighted an increased infiltration of tumor associated neutrophils (TANs), mirrored by a decreased recruitment of tumor associated macrophages (TAMs) compared to PyMT animals. Analysis of PyMT-Cxcr2-/- TANs revealed that they lost their killing ability compared to PyMT-Cxcr2+/+ TANs. The transcriptomic analysis of PyMT-Cxcr2-/- TANs showed that they had a more pronounced pro-tumor TAN2 profile compared to PyMT TANs. In particular, PyMT-Cxcr2-/- TANs displayed an up-regulation of the pathways involved in reactive oxygen species (ROS) production and angiogenesis and factors favoring metastasis, but reduced apoptosis. In summary, our data reveal that a lack of Cxcr2 provides TANs with pro-tumor effects.

Published
2021

2. Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis

Author

Rabiller, Lise, Robert, Virginie, Arlat, Adèle, Labit, Elodie, Ousset, Marielle, Salon, Marie, Coste, Agnès, Da Costa-Fernandes, Léa, Monsarrat, Paul, Ségui, Bruno, André, Mireille, Guissard, Christophe, Renoud, Marie-Laure, Silva, Marine, Mithieux, Gilles, Raymond-Letron, Isabelle, Pénicaud, Luc, Lorsignol, Anne, Casteilla, Louis, Dromard Berthézène, Cécile, and Cousin, Béatrice

Published
2021
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3. Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids

Author

Escudero, Mélanie, primary, Vaysse, Laurence, additional, Eke, Gozde, additional, Peyrou, Marion, additional, Villarroya, Francesc, additional, Bonnel, Sophie, additional, Jeanson, Yannick, additional, Boyer, Louisa, additional, Vieu, Christophe, additional, Chaput, Benoit, additional, Yao, Xi, additional, Deschaseaux, Frédéric, additional, Parny, Mélissa, additional, Raymond‐Letron, Isabelle, additional, Dani, Christian, additional, Carrière, Audrey, additional, Malaquin, Laurent, additional, and Casteilla, Louis, additional

Published
2023
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4. Leishmania infantum-exploited Nrf2 transcription factor as a virulence process to escape macrophage-driven ferroptosis-like leishmanicidal process

Author

Coste, Agnès, primary, Blot, Clément, additional, Coulson, Kimberley, additional, Salon, Marie, additional, Tertrais, Margot, additional, Planes, Remi, additional, Santoni, Karin, additional, Authier, Hélène, additional, Jacquemin, Godefroy, additional, Rahabi, Mouna, additional, Parny, Mélissa, additional, Raymond-Letron, Isabelle, additional, Meunier, Etienne, additional, and Lefèvre, Lise, additional

Published
2023
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5. Supplementary Data from CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

Author

Farge, Thomas, primary, Nakhle, Jean, primary, Lagarde, Damien, primary, Cognet, Guillaume, primary, Polley, Nathaniel, primary, Castellano, Rémy, primary, Nicolau, Marie-Laure, primary, Bosc, Claudie, primary, Sabatier, Marie, primary, Sahal, Ambrine, primary, Saland, Estelle, primary, Jeanson, Yannick, primary, Guiraud, Nathan, primary, Boet, Emeline, primary, Bergoglio, Camille, primary, Gotanègre, Mathilde, primary, Mouchel, Pierre-Luc, primary, Stuani, Lucille, primary, Larrue, Clément, primary, Sallese, Marie, primary, De Mas, Véronique, primary, Moro, Cedric, primary, Dray, Cédric, primary, Collette, Yves, primary, Raymond-Letron, Isabelle, primary, Ader, Isabelle, primary, Récher, Christian, primary, Sarry, Jean-Emmanuel, primary, Cabon, Florence, primary, Vergez, François, primary, and Carrière, Audrey, primary

Published
2023
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6. Table S2 from CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

Author

Farge, Thomas, primary, Nakhle, Jean, primary, Lagarde, Damien, primary, Cognet, Guillaume, primary, Polley, Nathaniel, primary, Castellano, Rémy, primary, Nicolau, Marie-Laure, primary, Bosc, Claudie, primary, Sabatier, Marie, primary, Sahal, Ambrine, primary, Saland, Estelle, primary, Jeanson, Yannick, primary, Guiraud, Nathan, primary, Boet, Emeline, primary, Bergoglio, Camille, primary, Gotanègre, Mathilde, primary, Mouchel, Pierre-Luc, primary, Stuani, Lucille, primary, Larrue, Clément, primary, Sallese, Marie, primary, De Mas, Véronique, primary, Moro, Cedric, primary, Dray, Cédric, primary, Collette, Yves, primary, Raymond-Letron, Isabelle, primary, Ader, Isabelle, primary, Récher, Christian, primary, Sarry, Jean-Emmanuel, primary, Cabon, Florence, primary, Vergez, François, primary, and Carrière, Audrey, primary

Published
2023
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7. Data from CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

Author

Farge, Thomas, primary, Nakhle, Jean, primary, Lagarde, Damien, primary, Cognet, Guillaume, primary, Polley, Nathaniel, primary, Castellano, Rémy, primary, Nicolau, Marie-Laure, primary, Bosc, Claudie, primary, Sabatier, Marie, primary, Sahal, Ambrine, primary, Saland, Estelle, primary, Jeanson, Yannick, primary, Guiraud, Nathan, primary, Boet, Emeline, primary, Bergoglio, Camille, primary, Gotanègre, Mathilde, primary, Mouchel, Pierre-Luc, primary, Stuani, Lucille, primary, Larrue, Clément, primary, Sallese, Marie, primary, De Mas, Véronique, primary, Moro, Cedric, primary, Dray, Cédric, primary, Collette, Yves, primary, Raymond-Letron, Isabelle, primary, Ader, Isabelle, primary, Récher, Christian, primary, Sarry, Jean-Emmanuel, primary, Cabon, Florence, primary, Vergez, François, primary, and Carrière, Audrey, primary

Published
2023
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9. CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

Author

Farge, Thomas, primary, Nakhle, Jean, additional, Lagarde, Damien, additional, Cognet, Guillaume, additional, Polley, Nathaniel, additional, Castellano, Rémy, additional, Nicolau, Marie-Laure, additional, Bosc, Claudie, additional, Sabatier, Marie, additional, Sahal, Ambrine, additional, Saland, Estelle, additional, Jeanson, Yannick, additional, Guiraud, Nathan, additional, Boet, Emeline, additional, Bergoglio, Camille, additional, Gotanègre, Mathilde, additional, Mouchel, Pierre-Luc, additional, Stuani, Lucille, additional, Larrue, Clément, additional, Sallese, Marie, additional, De Mas, Véronique, additional, Moro, Cedric, additional, Dray, Cédric, additional, Collette, Yves, additional, Raymond-Letron, Isabelle, additional, Ader, Isabelle, additional, Récher, Christian, additional, Sarry, Jean-Emmanuel, additional, Cabon, Florence, additional, Vergez, François, additional, and Carrière, Audrey, additional

Published
2023
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11. Supplementary Figure S5 from RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

Author

Calvayrac, Olivier, primary, Pradines, Anne, primary, Raymond-Letron, Isabelle, primary, Rouquette, Isabelle, primary, Bousquet, Emilie, primary, Lauwers-Cances, Valérie, primary, Filleron, Thomas, primary, Cadranel, Jacques, primary, Beau-Faller, Michèle, primary, Casanova, Anne, primary, Milia, Julie, primary, Favre, Gilles, primary, and Mazières, Julien, primary

Published
2023
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12. Supplementary Table S1 from RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

Author

Calvayrac, Olivier, primary, Pradines, Anne, primary, Raymond-Letron, Isabelle, primary, Rouquette, Isabelle, primary, Bousquet, Emilie, primary, Lauwers-Cances, Valérie, primary, Filleron, Thomas, primary, Cadranel, Jacques, primary, Beau-Faller, Michèle, primary, Casanova, Anne, primary, Milia, Julie, primary, Favre, Gilles, primary, and Mazières, Julien, primary

Published
2023
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13. Legends to supplementary figures and tables from RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer

Author

Calvayrac, Olivier, primary, Pradines, Anne, primary, Raymond-Letron, Isabelle, primary, Rouquette, Isabelle, primary, Bousquet, Emilie, primary, Lauwers-Cances, Valérie, primary, Filleron, Thomas, primary, Cadranel, Jacques, primary, Beau-Faller, Michèle, primary, Casanova, Anne, primary, Milia, Julie, primary, Favre, Gilles, primary, and Mazières, Julien, primary

Published
2023
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14. Supplementary Figure 3 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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15. Supplementary Methods, Results and Figures 1 to 5 from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake

Author

Bastide, Nadia M., primary, Chenni, Fatima, primary, Audebert, Marc, primary, Santarelli, Raphaelle L., primary, Taché, Sylviane, primary, Naud, Nathalie, primary, Baradat, Maryse, primary, Jouanin, Isabelle, primary, Surya, Reggie, primary, Hobbs, Ditte A., primary, Kuhnle, Gunter G., primary, Raymond-Letron, Isabelle, primary, Gueraud, Françoise, primary, Corpet, Denis E., primary, and Pierre, Fabrice H.F., primary

Published
2023
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16. Data from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake

Author

Bastide, Nadia M., primary, Chenni, Fatima, primary, Audebert, Marc, primary, Santarelli, Raphaelle L., primary, Taché, Sylviane, primary, Naud, Nathalie, primary, Baradat, Maryse, primary, Jouanin, Isabelle, primary, Surya, Reggie, primary, Hobbs, Ditte A., primary, Kuhnle, Gunter G., primary, Raymond-Letron, Isabelle, primary, Gueraud, Françoise, primary, Corpet, Denis E., primary, and Pierre, Fabrice H.F., primary

Published
2023
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17. Data from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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18. Supplementary Figure 5 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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19. Supplementary Figure 6 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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20. Supplementary Figure 2 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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21. Supplementary Figure 4 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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22. Supplementary Figure 1 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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23. Supplementary Methods, Table 1 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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24. Supplementary Figure 7 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Author

Péqueux, Christel, primary, Raymond-Letron, Isabelle, primary, Blacher, Silvia, primary, Boudou, Frédéric, primary, Adlanmerini, Marine, primary, Fouque, Marie-José, primary, Rochaix, Philippe, primary, Noël, Agnès, primary, Foidart, Jean-Michel, primary, Krust, Andrée, primary, Chambon, Pierre, primary, Brouchet, Laurent, primary, Arnal, Jean-François, primary, and Lenfant, Françoise, primary

Published
2023
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25. Mutation of Arginine 264 on ERα (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility

Author

Adlanmerini, Marine, Fébrissy, Chanaelle, Zahreddine, Rana, Vessières, Emilie, Buscato, Mélissa, Solinhac, Romain, Favre, Julie, Anquetil, Typhaine, Guihot, Anne-Laure, Boudou, Frederic, Raymond-Letron, Isabelle, Chambon, Pierre, Gourdy, Pierre, Ohlsson, Claes, Laurell, Henrik, Fontaine, Coralie, Metivier, Raphaël, Le Romancer, Muriel, Henrion, Daniel, Arnal, Jean-Francois, and Lenfant, Francoise

Published
2020
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27. Characterization and Safety Profile of a New Combined Advanced Therapeutic Medical Product Platelet Lysate-Based Fibrin Hydrogel for Mesenchymal Stromal Cell Local Delivery in Regenerative Medicine

Author

Canceill, Thibault, primary, Jourdan, Géraldine, additional, Kémoun, Philippe, additional, Guissard, Christophe, additional, Monsef, Yanad Abou, additional, Bourdens, Marion, additional, Chaput, Benoit, additional, Cavalie, Sandrine, additional, Casteilla, Louis, additional, Planat-Bénard, Valérie, additional, Monsarrat, Paul, additional, and Raymond-Letron, Isabelle, additional

Published
2023
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28. Loss of function of membrane estrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility

Author

Rusidzé, Mariam, primary, Faure, Mélanie, additional, Sicard, Pierre, additional, Raymond-Letron, Isabelle, additional, Giton, Frank, additional, Vessieres, Emilie, additional, Prevot, Vincent, additional, Henrion, Daniel, additional, Arnal, Jean-François, additional, Cornil, Charlotte, additional, and Lenfant, Françoise, additional

Published
2022
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31. Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility

Author

Rusidzé, Mariam, primary, Faure, Mélanie C., additional, Sicard, Pierre, additional, Raymond-Letron, Isabelle, additional, Giton, Frank, additional, Vessieres, Emilie, additional, Prevot, Vincent, additional, Henrion, Daniel, additional, Arnal, Jean-François, additional, Cornil, Charlotte A., additional, and Lenfant, Françoise, additional

Published
2022
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33. A Spectral Principal Component Analysis-Based Framework for Composite Hard/Soft Tissue Fluorescence Image Investigation

Author

Piriou, Marie, primary, Lorenzo, Corinne, additional, Raymond-Letron, Isabelle, additional, Coronas-Dupuis, Sophie, additional, Pieruccioni, Laetitia, additional, Rouquette, Jacques, additional, Guissard, Christophe, additional, Chaumont, Jade, additional, Casteilla, Louis, additional, Planat-Benard, Valérie, additional, Kemoun, Philippe, additional, and Monsarrat, Paul, additional

Published
2022
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34. Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Author

Adlanmerini, Marine, Solinhac, Romain, Abot, Anne, Fabre, Aurélie, Raymond-Letron, Isabelle, Guihot, Anne-Laure, Boudou, Frédéric, Sautier, Lucile, Vessières, Emilie, Kim, Sung Hoon, Lière, Philippe, Fontaine, Coralie, Krust, Andrée, Chambon, Pierre, Katzenellenbogen, John A., Gourdy, Pierre, Shaul, Philip W., Henrion, Daniel, Arnal, Jean-François, and Lenfant, Françoise

Published
2014

36. Intrinsic Capacity Assessment in the Caniage Pilot Cohort

Author

Blanchard, Tiphaine, Jourdan, Géraldine, Dupuis-Coronas, Sophie, Pouch-Buck, Petra, Richard, Oceane, Mogicato, Giovanni, Casteilla, Louis, Raymond-Letron, Isabelle, Priymenko, Nathalie, and LESUR, Hélène

Subjects
[SDV] Life Sciences [q-bio]
Published
2022

38. The RAS‐related GTPase RHOB confers resistance to EGFR‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT‐dependent mechanism

Author

Calvayrac, Olivier, Mazières, Julien, Figarol, Sarah, Marty‐Detraves, Claire, Raymond‐Letron, Isabelle, Bousquet, Emilie, Farella, Magali, Clermont‐Taranchon, Estelle, Milia, Julie, Rouquette, Isabelle, Guibert, Nicolas, Lusque, Amélie, Cadranel, Jacques, Mathiot, Nathalie, Savina, Ariel, Pradines, Anne, and Favre, Gilles

Published
2017
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39. Pyogenic granuloma of the cornea in a pony: Uncommon complication of corneal wound healing.

Author

Regnier, Alain, Landrevie, Clara, Robin, Marie‐Claire, Einsweiler, Delphine, Douet, Jean‐Yves, and Raymond‐Letron, Isabelle

Subjects
CORNEA injuries, WOUND healing, INJURY complications, GRANULOMA, PONIES, VETERINARY ophthalmology, CORNEA
Abstract

A 6‐year‐old miniature Shetland pony mare was referred for evaluation of a left corneal mass, which developed from the healing tissue of a corneal traumatic ulceration that had occurred 4 weeks previously. On gross examination, a spherical, smooth‐surfaced, and pink‐colored lesion of about 1 cm in diameter was protruding from the left palpebral fissure. Ophthalmic examination revealed that it was attached to the scar tissue of the cornea, and that one corpora nigra was adherent to the posterior face of corneal wounded area, without sign of uveitis. The remainder of the ophthalmic examination was unremarkable. The mass was excised, and cryotherapy was used as an adjunctive therapy. Histopathology of the resected mass was consistent with a pyogenic granuloma on the basis of radially oriented proliferating capillaries, embedded in immature granulation tissue containing an infiltrate of neutrophils, plasma cells and eosinophils. There were no histological features of malignancy. 2 months after surgery, the ventral part of the fibrotic corneal scar was slightly raised by a pink tissue, suggesting possible recurrence of the initial lesion. A second cryotherapy was performed over the leukoma area. No recurrence has been noted for a follow‐up period of more than 25 months. Pyogenic granuloma is a benign proliferative fibrovascular response that typically develops after trauma or surgery. Corneal involvement is rare in humans, and to the authors' knowledge has never been documented in veterinary ophthalmology. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”

Author

Silva, Amanda K.A., primary, Morille, Marie, additional, Piffoux, Max, additional, Arumugam, Surendar, additional, Mauduit, Phlippe, additional, Larghero, Jérôme, additional, Bianchi, Arnaud, additional, Aubertin, Kelly, additional, Blanc-Brude, Olivier, additional, Noël, Danièle, additional, Velot, Emilie, additional, Ravel, Célia, additional, Elie-Caille, Céline, additional, Sebbagh, Anna, additional, Boulanger, Chantal, additional, Wilhelm, Claire, additional, Rahmi, Gabriel, additional, Raymond-Letron, Isabelle, additional, Cherukula, Kondareddy, additional, Montier, Tristan, additional, Martinaud, Christophe, additional, Bach, Jean-Marie, additional, Favre-Bulle, Olivier, additional, Spadavecchia, Jolanda, additional, Jorgensen, Christian, additional, Menasché, Philippe, additional, Aussel, Clotilde, additional, Chopineau, Joël, additional, Mosser, Mathilde, additional, Ullah, Matti, additional, Sailliet, Nicolas, additional, Luciani, Nathalie, additional, Mathieu, Noëlle, additional, Rautou, Pierre-Emmanuel, additional, Brouard, Sophie, additional, Boireau, Wilfrid, additional, Jauliac, Sébastien, additional, Dedier, Marianne, additional, Trouvin, Jean-Hugues, additional, Gazeau, Florence, additional, Trouillas, Marina, additional, Peltzer, Juliette, additional, Monsel, Antoine, additional, and Banzet, Sébastien, additional

Published
2021
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42. Meiotic silencing in pigs: A case study in a translocated azoospermic boar

Author

Mary, Nicolas, Calgaro, Anne, Barasc, Harmonie, Bonnet, Nathalie, Ferchaud, Stéphane, Raymond-Letron, Isabelle, Ducos, Alain, Pinton, Alain, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Elevages Porcins Innovants (GenESI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Pinton, Alain, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, S, MSCI (meiotic sex chromosome inactivation) disturbance, Swine, [SDV]Life Sciences [q-bio], reciprocal translocation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, QH426-470, MSUC, I, Translocation, Genetic, Article, Pinton, A, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genetics, Animals, meiosis, Gene Silencing, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Azoospermia, Swine Diseases, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Bonnet, urogenital system, Barasc, Ferchaud, Calgaro, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, H, N, Chromatin, Ducos, [SDV] Life Sciences [q-bio], Mary, Karyotyping, Raymond-Letron, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], infertility, A. Meiotic Silencing in Pigs: A Case Study in a Translocated infertility
Abstract

Carriers of balanced constitutional reciprocal translocations usually present a normal phenotype, but often show reproductive disorders. For the first time in pigs, we analyzed the meiotic process of an autosome–autosome translocation associated with azoospermia. Meiotic process analysis revealed the presence of unpaired autosomal segments with histone γH2AX accumulation sometimes associated with the XY body. Additionally, γH2AX signals were observed on apparently synapsed autosomes other than the SSC1 or SSC15, as previously observed in Ataxia with oculomotor apraxia type 2 patients or knock-out mice for the Senataxin gene. Gene expression showed a downregulation of genes selected on chromosomes 1 and 15, but no upregulation of SSCX genes. We hypothesized that the total meiotic arrest observed in this boar might be due to the silencing of crucial autosomal genes by the mechanism referred to as meiotic silencing of unsynapsed chromatin (MSUC)., Les porteurs de translocations réciproques constitutionnelles équilibrées présentent généralement un phénotype normal, mais présentent souvent des troubles de la reproduction. Pour la première fois chez le porc, nous avons analysé le processus méiotique d'une translocation autosome-autosome associée à une azoospermie. L'analyse du processus méiotique a révélé la présence de segments autosomiques non appariés avec une accumulation d'histone γH2AX parfois associée à la vésicule sexuelle. De plus, des signaux γH2AX ont été observés sur des autosomes apparemment appariés autres que le SSC1 ou le SSC15, comme cela avait été précédemment observé chez des patients atteints d'Ataxie avec apraxie oculomotrice de type 2 ou chez des souris knock-out pour le gène de la senataxine. L'expression génique a montré une régulation négative des gènes sélectionnés sur les chromosomes 1 et 15, mais aucune régulation positive des gènes du SSCX. Nous avons émis l'hypothèse que l'arrêt méiotique total observé chez ce verrat pourrait être dû à la répression de gènes autosomiques cruciaux par le mécanisme appelé " meiotic silencing of unsynapsed chromatin" (MSUC).

Published
2021

43. Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

Author

Rusidze', Mariam, Faure, Me'lanie C., Sicard, Pierre, Raymond-Letron, Isabelle, Giton, Frank, Vessieres, Emilie, Prevot, Vincent, Henrion, Daniel, Arnal, Jean-François, Cornil, Charlotte A., and Lenfant, Françoise

Subjects
TROPHOBLAST, GENITALIA, FERTILITY, ESTROGEN, VASCULAR endothelial growth factors, NEONATAL death
Abstract

The binding of 17ß-oestradiol to oestrogen receptor alpha (ERa) plays a crucial role in the control of reproduction, acting through both nuclear and membrane-initiated signalling. To study the physiological role of membrane ERa in the reproductive system, we used the C451A-ERa mouse model with selective loss of function of membrane ERa. Despite C451A-ERa mice being described as sterile, daily weighing and ultrasound imaging revealed that homozygous females do become pregnant, allowing the investigation of the role of ERa during pregnancy for the first time. All neonatal deaths of the mutant offspring mice resulted from delayed parturition associated with failure in pre-term progesterone withdrawal. Moreover, pregnant C451A-ERa females exhibited partial intrauterine embryo arrest at about E9.5. The observed embryonic lethality resulted from altered expansion of Tpbpapositive spiral artery-associated trophoblast giant cells into the utero-placental unit, which is associated with an imbalance in expression of angiogenic factors. Together, these processes control the trophoblast-mediated spiral arterial remodelling. Hence, loss of membrane ERa within maternal tissues clearly alters the activity of invasive trophoblast cells during placentogenesis. This previously unreported function of membrane ERa could open new avenues towards a better understanding of human pregnancy-associated pathologies. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Healthy Aging Biomarkers: The INSPIRE's Contribution

Author

Vergnolle, Nathalie, Ader, Isabelle, Penicaud, Luc, Raymond Letron, Isabelle, Andrieu, Sandrine, Rolland, Julien Yves, Barreto De Souto, Philippe, Vellas, Bruno, Guyonnet, Sophie, Beard, J.R., Parini, Angelo, Davezac, Noélie, Dray, Cédric, Gourdy, P., Rampon, Claire, Valet, Phillippe, Fazilleau, Nicolas, Payoux, Pierre, Sierra, Felipe, Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Geroscience and rejuvenation research center (RESTORE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Gérontopôle, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse], University of New South Wales [Sydney] (UNSW), Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Toulouse Neuro Imaging Center (ToNIC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Institut du Vieillissement, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Region Occitanie/Pyrenees-Mediterranee (Reference number: 1901175), European Regional Development Fund (ERDF) (Project number: MP0022856), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Recherches sur la Cognition Animale - UMR5169 (CRCA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), and SEGUIN, Nathalie

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, healthy aging, frailty, dependence, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.BIO] Life Sciences [q-bio]/Biotechnology
Abstract

International audience; The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. While the current approach to the biology of aging is mainly focused on parenchymal cells, we propose that age-related loss of function is largely determined by three elements which constitute the general ground supporting the different specific parenchyma: i.e. the stroma, the immune system and metabolism. Such strategy that is implemented in INSPIRE projects can strongly help to find a composite biomarker capable of predicting changes in capacity across the life course with thresholds signalling frailty and care dependence.

Published
2021

48. The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Author

Abot, Anne, Fontaine, Coralie, Buscato, Mélissa, Solinhac, Romain, Flouriot, Gilles, Fabre, Aurélie, Drougard, Anne, Rajan, Shyamala, Laine, Muriel, Milon, Alain, Muller, Isabelle, Henrion, Daniel, Adlanmerini, Marine, Valéra, Marie-Cécile, Gompel, Anne, Gerard, Céline, Péqueux, Christel, Mestdagt, Mélanie, Raymond-Letron, Isabelle, Knauf, Claude, Ferriere, François, Valet, Philippe, Gourdy, Pierre, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Lenfant, Françoise, Greene, Geoffrey L, Foidart, Jean-Michel, and Arnal, Jean-François

Published
2014
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