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15 results on '"Rearte, Bárbara"'

7. Additional file 2 of Inhibition of hyperprogressive cancer disease induced by immune-checkpoint blockade upon co-treatment with meta-tyrosine and p38 pathway inhibitor

Author

Montagna, Daniela R., Duarte, Alejandra, Chiarella, Paula, Rearte, Bárbara, Bustuoabad, Oscar D., Vermeulen, Mónica, and Ruggiero, Raúl A.

Abstract

Additional file 2: Supplementary Figure 1. Idealized monotonic (A) and biphasic (B) anti-tumor immune reaction curve. Supplementary Figure 2. Counteracting effect of LMM3 lysates on the capacity of LPS to promote the maturation of DC. Supplementary Figure 3. Classical markers of antitumor immunity in MC-C and LMM3 tumor-bearing mice. Supplementary Figure 4. Expression of PD-1 in CD4+ (A, B, C) and CD8+ (D, E, F) splenic lymphocytes of MC-C and LMM3 bearing mice. Supplementary Figure 5. (A, C)Kinetics of MC-C and LMM3 growing tumors in euthymic, nude, and NSG mice. Supplementary Figure 6. Percentage of in vitro proliferation of splenic CD3+ cells.

Published
2022
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8. Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Author

Pineda, Gonzalo Ezequiel, primary, Rearte, Bárbara, additional, Todero, María Florencia, additional, Bruballa, Andrea Cecilia, additional, Bernal, Alan Mauro, additional, Fernandez-Brando, Romina Jimena, additional, Isturiz, Martin Amadeo, additional, Zotta, Elsa, additional, Alba-Soto, Catalina Dirney, additional, Palermo, Marina Sandra, additional, and Ramos, María Victoria, additional

Published
2021
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11. Formation of Foamy Macrophages by Tuberculous Pleural Effusions Is Triggered by the Interleukin-10/Signal Transducer and Activator of Transcription 3 Axis through ACAT Upregulation

Author

Genoula, Melanie, primary, Marín Franco, José Luis, additional, Dupont, Maeva, additional, Kviatcovsky, Denise, additional, Milillo, Ayelén, additional, Schierloh, Pablo, additional, Moraña, Eduardo Jose, additional, Poggi, Susana, additional, Palmero, Domingo, additional, Mata-Espinosa, Dulce, additional, González-Domínguez, Erika, additional, León Contreras, Juan Carlos, additional, Barrionuevo, Paula, additional, Rearte, Bárbara, additional, Córdoba Moreno, Marlina Olyissa, additional, Fontanals, Adriana, additional, Crotta Asis, Agostina, additional, Gago, Gabriela, additional, Cougoule, Céline, additional, Neyrolles, Olivier, additional, Maridonneau-Parini, Isabelle, additional, Sánchez-Torres, Carmen, additional, Hernández-Pando, Rogelio, additional, Vérollet, Christel, additional, Lugo-Villarino, Geanncarlo, additional, Sasiain, María del Carmen, additional, and Balboa, Luciana, additional

Published
2018
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15. Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice.

Author

Rearte, Bárbara, Maglioco, Andrea, Machuca, Damián, Greco, Daiana Martire, Landoni, Verónica I, Rodriguez-Rodrigues, Nahuel, Meiss, Roberto, Fernández, Gabriela C, and Isturiz, Martín A

Subjects
*DEHYDROEPIANDROSTERONE, *METOPIRONE, *HUMORAL immunity, *CELLULAR immunity, *IMMUNE response, *ENDOTOXINS, *IMMUNOCOMPROMISED patients, *LABORATORY mice
Abstract

Prior exposure to endotoxins renders the host temporarily refractory to subsequent endotoxin challenge (endotoxin tolerance). Clinically, this state has also been pointed out as the initial cause of the non-specific humoral and cellular immunosuppression described in these patients. We recently demonstrated the restoration of immune response with mifepristone (RU486), a receptor antagonist of glucocorticoids. Here we report the treatment with other modulators of glucocorticoids, i.e. dehydroepiandrosterone (DHEA), a hormone with anti-glucocorticoid properties, or metyrapone (MET) an inhibitor of corticosterone synthesis. These drugs were able to partially, but significantly, restore the humoral immune response in immunosuppressed mice. A significant recovery of proliferative responsiveness was also observed when splenocytes were obtained from DHEA- or MET-treated immunosuppressed mice. In addition, these treatments restored the hypersensitivity response in immunosuppressed mice. Finally, although neither DHEA nor MET improved the reduced CD4 lymphocyte count in spleen from immunosuppressed mice, both treatments promoted spleen architecture reorganization, partially restoring the distinct cellular components and their localization in the spleen. The results from this study indicate that DHEA and MET could play an important role in the restoration of both adaptive humoral and cellular immune response in LPS-immunosuppressed mice, reinforcing the concept of a central involvement of endogenous glucocorticoids on this phenomenon. [ABSTRACT FROM AUTHOR]

Published
2014
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