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1. Dynamic Combinatorial Mass Spectrometry Leads to Metallo-β-lactamase Inhibitors.

Author

Benoît M. R. Liénard, Rebekka Hüting, Patricia Lassaux, Moreno Galleni, Jean-Marie Frère, and Christopher J. Schofield

Subjects
*MASS spectrometry, *MOLECULAR spectroscopy, *ENZYME inhibitors, *PROTEINS
Abstract

The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-β-lactamase enabled the rapid identification of an inhibitor with a Kiof <1 µM. The study exemplifies the utility of protein-MS for screening dynamic mixtures of potential enzyme–inhibitors. [ABSTRACT FROM AUTHOR]

Published
2008
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