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3. Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial

Author

Cuadrado-Lavín, Antonio, Olmos, José Manuel, Cifrian, José Manuel, Gimenez, Teresa, Gandarillas, Marco Antonio, García-Saiz, Mar, Rebollo, Maria Henar, Martínez-Taboada, Victor, López-Hoyos, Marcos, Fariñas, María Carmen, and Crespo, Javier

Published
2020
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4. Democracia y desinformación : Nuevas formas de polarización, discursos de odio y campañas en redes. Respuestas regulatorias de Europa y América Latina

Author

Maíllo, Isabel Serrano, Corredoira, Loreto, Anguita, Pedro, de Andrade Monteiro, Vitor, Jimeno, Tamara Antona, Ferrer, Ferran Armengol, Rueda, Altus Alejandro Baquero, Bernad, Javier Barriuso, Bel, Ignacio, Presuel, Rodrigo Cetina, Martínez, Mariluz Congosto, Fedchenko, Yevhen, Gómez, Rocío, Aguilar, Juan Manuel Gozález, Gonzalo, Miguel Ángel, Jans, Alejandra, Castro, Oscar Jaramillo, Blanes, María José Labrador, Mayagoitia-Soria, Ana, Sánchez, Adrián Merinero, Osuna, José Javier Olivas, Rebollo, María Antonia Paz, Portero, Florentino, Núñez, Rafael Rubio, Molina, José Manuel Saavedra, Boj, Francisco Segado, Díaz, Nairbis Desiree Sibrian, Vincent-Ibáñez, Mireya, Camacho, Jessica Zorogastua, Maíllo, Isabel Serrano, Corredoira, Loreto, Anguita, Pedro, de Andrade Monteiro, Vitor, Jimeno, Tamara Antona, Ferrer, Ferran Armengol, Rueda, Altus Alejandro Baquero, Bernad, Javier Barriuso, Bel, Ignacio, Presuel, Rodrigo Cetina, Martínez, Mariluz Congosto, Fedchenko, Yevhen, Gómez, Rocío, Aguilar, Juan Manuel Gozález, Gonzalo, Miguel Ángel, Jans, Alejandra, Castro, Oscar Jaramillo, Blanes, María José Labrador, Mayagoitia-Soria, Ana, Sánchez, Adrián Merinero, Osuna, José Javier Olivas, Rebollo, María Antonia Paz, Portero, Florentino, Núñez, Rafael Rubio, Molina, José Manuel Saavedra, Boj, Francisco Segado, Díaz, Nairbis Desiree Sibrian, Vincent-Ibáñez, Mireya, and Camacho, Jessica Zorogastua

Published
2024

5. Baseline Mapping of Neglected Tropical Diseases in Africa: The Accelerated WHO/AFRO Mapping Project

Author

Rebollo, Maria P., primary, Onyeze, Adiele Nkasiobi, additional, Tiendrebeogo, Alexandre, additional, Senkwe, Mutale Nsakashalo, additional, Impouma, Benido, additional, Ogoussan, Kisito, additional, Zouré, Honorat G. M., additional, Deribe, Kebede, additional, Cano, Jorge, additional, Kinvi, Ekoue Boniface, additional, Majewski, Andrew, additional, Ottesen, Eric A., additional, and Lammie, Patrick, additional

Published
2021
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6. On the use of time-dependent success criteria within risk-informed analyses. Application to LONF-ATWS sequences in PWR reactors

Author

Sanchez-Torrijos, Jorge, Queral, Cesar, Paris, Carlos, Rebollo, Maria Jose, Sanchez-Perea, Miguel, and Posada, Jose Maria

Abstract

The classical Probabilistic Safety Analysis (PSA) does not include any time dependence explicitly. However, the success criteria (SC) could evolve during the cycle for some initiating events. In that sense, there is a type of sequence in which this time-dependency is quite important, the family of Anticipated Transient without Scram (ATWS) sequences in Pressurized Water Reactors. Therefore, a new risk-informed approach is proposed in this paper, which makes it possible to obtain the time-dependent SC evolution of the safety functions affected by the Moderator Temperature Coefficient (MTC) value. Then, the evolution of the ATWS conditional core damage probability (CCDP) could be obtained using a PSA model. To quantify the CCDP, the average values of the time-dependent failure probabilities must be computed. Finally, the comparison between the CCDP obtained through the application of the classical PSA approach and the new one makes it possible to quantify the impact of time-dependence on the SC of the headers that this new risk-informed ATWS approach can provide.

Published
2022
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7. African regional progress and status of the programme to eliminate lymphatic filariasis: 2000–2020

Author

Deribe, Kebede, Bakajika, Didier K, Zoure, Honorat Marie-Gustave, Gyapong, John O, Molyneux, David, and Rebollo, Maria P

Subjects
wc_20, wc_880, wc_680, wa_395
Abstract

To eliminate lymphatic filariasis (LF) by 2020, the World Health Organization (WHO) has launched a campaign against the disease. Since the launch in 2000, significant progress has been made to achieve this ambitious goal. In this article we review the progress and status of the LF programme in Africa through the WHO neglected tropical diseases preventive chemotherapy databank, the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN) portal and other publications. In the African Region there are 35 countries endemic for LF. The Gambia was reclassified as not requiring preventive chemotherapy in 2015, while Togo and Malawi eliminated LF as a public health problem in 2017 and 2020, respectively. Cameroon discontinued mass drug administration (MDA) and transitioned to post-MDA surveillance to validate elimination. The trajectory of coverage continues to accelerate; treatment coverage increased from 0.1% in 2000 to 62.1% in 2018. Geographical coverage has also significantly increased, from 62.7% in 2015 to 78.5% in 2018. In 2019, 23 of 31 countries requiring MDA achieved 100% geographic coverage. Although much remains to be done, morbidity management and disability prevention services have steadily increased in recent years. Vector control interventions conducted by other programmes, particularly malaria vector control, have had a profound effect in stopping transmission in some endemic countries in the region. In conclusion, significant progress has been made in the LF programme in the region while we identify the key remaining challenges in achieving an Africa free of LF.

Published
2021

10. Results of a confirmatory mapping tool for Lymphatic filariasis endemicity classification in areas where transmission was uncertain in Ethiopia

Author

Sime, Heven, primary, Gass, Katherine M., additional, Mekasha, Sindew, additional, Assefa, Ashenafi, additional, Woyessa, Adugna, additional, Shafi, Oumer, additional, Meribo, Kadu, additional, Kebede, Biruck, additional, Ogoussan, Kisito, additional, Pelletreau, Sonia, additional, Bockarie, Moses J., additional, Kebede, Amha, additional, and Rebollo, Maria P., additional

Published
2018
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14. Optimising cluster survey design for planning schistosomiasis preventive chemotherapy

Author

Knowles, Sarah C. L., primary, Sturrock, Hugh J. W., additional, Turner, Hugo, additional, Whitton, Jane M., additional, Gower, Charlotte M., additional, Jemu, Samuel, additional, Phillips, Anna E., additional, Meite, Aboulaye, additional, Thomas, Brent, additional, Kollie, Karsor, additional, Thomas, Catherine, additional, Rebollo, Maria P., additional, Styles, Ben, additional, Clements, Michelle, additional, Fenwick, Alan, additional, Harrison, Wendy E., additional, and Fleming, Fiona M., additional

Published
2017
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15. An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys

Author

Cano, Jorge, Moraga, Paula, Nikolay, Birgit, Rebollo, Maria P., Okorie, Patricia N., Davies, Emmanuel, Njenga, Sammy M., Bockarie, Moses, and Brooker, Simon J.

Subjects
wc_880, qw_573, qx_20, qx_301, parasitic diseases
Abstract

Background \ud The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known.\ud \ud Methods \ud This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures.\ud \ud Results and Conclusions \ud In some settings there was a very large disparity, up to 40–70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

Published
2015

16. The global distribution and transmission limits of lymphatic filariasis: past and present

Author

Cano, Jorge, Rebollo, Maria P, Golding, Nick, Pullan, Rachel L, Crellen, Thomas, Soler, Anna, Hope, Louise A Kelly, Lindsay, Steve W, Hay, Simon I, Bockarie, Moses J, and Brooker, Simon J

Subjects
Infectious Diseases, Parasitology
Abstract

BACKGROUND: Lymphatic filariasis (LF) is one of the neglected tropical diseases targeted for global elimination by 2020 and to guide elimination efforts countries have, in recent years, conducted extensive mapping surveys. Documenting the past and present distribution of LF and its environmental limits is important for a number of reasons. Here, we present an initiative to develop a global atlas of LF and present a new global map of the limits of LF transmission. METHODS: We undertook a systematic search and assembly of prevalence data worldwide and used a suite of environmental and climatic data and boosted regression trees (BRT) modelling to map the transmission limits of LF. RESULTS: Data were identified for 66 of the 72 countries currently endemic and for a further 17 countries where LF is no longer endemic. Our map highlights a restricted and highly heterogeneous distribution in sub-Saharan Africa, with transmission more widespread in West Africa compared to east, central and southern Africa where pockets of transmission occur. Contemporary transmission occurs across much of south and South-east Asia and the Pacific. Interestingly, the risk map reflects environmental conditions suitable for LF transmission across Central and South America, including the southern States of America, although active transmission is only known in a few isolated foci. In countries that have eliminated LF, our predictions of environmental suitability are consistent with historical distribution. CONCLUSIONS: The global distribution of LF is highly heterogeneous and geographically targeted and sustained control will be required to achieve elimination. This first global map can help evaluate the progress of interventions and guide surveillance activities.

Published
2014

18. Modelling the distribution and transmission intensity of lymphatic filariasis in sub-Saharan Africa prior to scaling up interventions: integrated use of geostatistical and mathematical modelling

Author

Moraga, Paula, primary, Cano, Jorge, additional, Baggaley, Rebecca F., additional, Gyapong, John O., additional, Njenga, Sammy M., additional, Nikolay, Birgit, additional, Davies, Emmanuel, additional, Rebollo, Maria P., additional, Pullan, Rachel L., additional, Bockarie, Moses J., additional, Hollingsworth, T. Déirdre, additional, Gambhir, Manoj, additional, and Brooker, Simon J., additional

Published
2015
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21. Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia

Author

Deribe, Kebede, primary, Cano, Jorge, additional, Newport, Melanie J., additional, Golding, Nick, additional, Pullan, Rachel L., additional, Sime, Heven, additional, Gebretsadik, Abeba, additional, Assefa, Ashenafi, additional, Kebede, Amha, additional, Hailu, Asrat, additional, Rebollo, Maria P., additional, Shafi, Oumer, additional, Bockarie, Moses J., additional, Aseffa, Abraham, additional, Hay, Simon I., additional, Reithinger, Richard, additional, Enquselassie, Fikre, additional, Davey, Gail, additional, and Brooker, Simon J., additional

Published
2015
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24. Elimination of Lymphatic Filariasis in The Gambia

Author

Rebollo, Maria P., primary, Sambou, Sana Malang, additional, Thomas, Brent, additional, Biritwum, Nana-Kwadwo, additional, Jaye, Momodou C., additional, Kelly-Hope, Louise, additional, Escalada, Alba Gonzalez, additional, Molyneux, David H., additional, and Bockarie, Moses J., additional

Published
2015
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25. Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping

Author

Deribe, Kebede, primary, Brooker, Simon J., additional, Pullan, Rachel L., additional, Sime, Heven, additional, Gebretsadik, Abeba, additional, Assefa, Ashenafi, additional, Kebede, Amha, additional, Hailu, Asrat, additional, Rebollo, Maria P., additional, Shafi, Oumer, additional, Bockarie, Moses J., additional, Aseffa, Abraham, additional, Reithinger, Richard, additional, Cano, Jorge, additional, Enquselassie, Fikre, additional, Newport, Melanie J., additional, and Davey, Gail, additional

Published
2015
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27. Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia

Author

Sime, Heven, primary, Deribe, Kebede, additional, Assefa, Ashenafi, additional, Newport, Melanie J, additional, Enquselassie, Fikre, additional, Gebretsadik, Abeba, additional, Kebede, Amha, additional, Hailu, Asrat, additional, Shafi, Oumer, additional, Aseffa, Abraham, additional, Reithinger, Richard, additional, Brooker, Simon J, additional, Pullan, Rachel L, additional, Cano, Jorge, additional, Meribo, Kadu, additional, Pavluck, Alex, additional, Bockarie, Moses J, additional, Rebollo, Maria P, additional, and Davey, Gail, additional

Published
2014
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29. Integrated School-Based Surveillance for Soil-Transmitted Helminth Infections and Lymphatic Filariasis in Gampaha District, Sri Lanka

Author

Gunawardena, Sharmini, primary, Weil, Gary J., additional, Ranasinghe, Udaya B., additional, Nagodavithana, Kumara C., additional, Samarasekara, Sandhya D., additional, Karunaweera, Nadira D., additional, Gunawardena, Nipul K., additional, Rao, Ramakrishna U., additional, Rebollo, Maria P., additional, de Silva, Nilanthi R., additional, and Kahathuduwa, Ganga, additional

Published
2014
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30. No Evidence for Lymphatic Filariasis Transmission in Big Cities Affected by Conflict Related Rural-Urban Migration in Sierra Leone and Liberia

Author

de Souza, Dziedzom K., primary, Sesay, Santigie, additional, Moore, Marnijina G., additional, Ansumana, Rashid, additional, Narh, Charles A., additional, Kollie, Karsor, additional, Rebollo, Maria P., additional, Koudou, Benjamin G., additional, Koroma, Joseph B., additional, Bolay, Fatorma K., additional, Boakye, Daniel A., additional, and Bockarie, Moses J., additional

Published
2014
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33. Mutations in the rpoBGene of Rifampin-Resistant Mycobacterium tuberculosisIsolates in Spain and Their Rapid Detection by PCR–Enzyme-Linked Immunosorbent Assay

Author

Garcia, Lucia, Alonso-Sanz, Mercedes, Rebollo, Maria J., Tercero, Juan C., and Chaves, Fernando

Abstract

ABSTRACTGenetic alterations in the rpoBgene were characterized in 50 rifampin-resistant (Rifr) clinical isolates of Mycobacterium tuberculosiscomplex from Spain. A rapid PCR–enzyme-linked immunosorbent assay (ELISA) technique for the identification of rpoBmutations was evaluated with isolates of the M. tuberculosiscomplex and clinical specimens from tuberculosis patients that were positive for acid-fast bacilli (AFB). Sequence analysis demonstrated 11 differentrpoBmutations among the Rifrisolates in the study. The most frequent mutations were those associated with codon 531 (24 of 50; 48%) and codon 526 (11 of 50; 22%). Although the PCR-ELISA does not permit characterization of the specific Rifrallele within each strain, 10 of the 11 Rifrgenotypes were correctly identified by this method. We used the PCR-ELISA to predict the rifampin susceptibility of M. tuberculosiscomplex organisms from 30 AFB-positive sputum specimens. For 28 samples, of which 9 contained Rifrorganisms and 19 contained susceptible strains, results were concordant with those based on culture-based drug susceptibility testing and sequencing. Results from the remaining two samples could not be interpreted because of low bacillary load (microscopy score of 1+ for 1 to 9 microorganisms/100 fields). Our results suggest that the PCR-ELISA is an easy technique to implement and could be used as a rapid procedure for detecting rifampin resistance to complement conventional culture-based methods.

Published
2001
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34. Optical technique for the automatic detection and measurement of surface defects on thin metallic wires

Author

Sanchez-Brea, Luis Miguel, Siegmann, Philip, Rebollo, Maria Aurora, and Bernabeu, Eusebio

Abstract

In industrial applications of thin metallic wires it is important to characterize the surface defects of the wires. We present an optical technique for the automatic detection of surface defects on thin metallic wires (diameters, 50–2000 µm) that can be used in on-line systems for surface quality control. This technique is based on the intensity variations on the scattered cone generated when the wire is illuminated with a beam at oblique incidence. Our results are compared with those obtained by atomic-force microscopy and scanning-electron microscopy.

Published
2000

37. FIRST ESTIMATES OF THE DISEASE BURDEN OF PODOCONIOSIS IN ETHIOPIA

Author

Deribe, Kebede, Cano, Jorge, Newport, Melanie J., Golding, Nick, Pullan, Rachel L., Sime, Heven, Gebretsadik, Abeba, Assefa, Ashenafi, Misganaw, Awoke, Kebede, Amha, Hailu, Asrat, Rebollo, Maria P., Shafi, Oumer, Moses Bockarie, Aseffa, Abraham, Naghavi, Mohsen, Hay, Simon I., Reithinger, Richard, Enquselassie, Fikre, Brooker, Simon J., and Davey, Gail

40. Shrinking the Lymphatic Filariasis Map of Ethiopia: Reassessing the Population at Risk through Nationwide Mapping.

Author

Rebollo MP, Sime H, Assefa A, Cano J, Deribe K, Gonzalez-Escalada A, Shafi O, Davey G, Brooker SJ, Kebede A, and Bockarie MJ

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Endemic Diseases, Ethiopia epidemiology, Female, Humans, Male, Middle Aged, Prevalence, Risk Assessment, Young Adult, Elephantiasis, Filarial epidemiology, Topography, Medical
Abstract

Background: Mapping of lymphatic filariasis (LF) is essential for the delineation of endemic implementation units and determining the population at risk that will be targeted for mass drug administration (MDA). Prior to the current study, only 116 of the 832 woredas (districts) in Ethiopia had been mapped for LF. The aim of this study was to perform a nationwide mapping exercise to determine the number of people that should be targeted for MDA in 2016 when national coverage was anticipated., Methodology/principal Finding: A two-stage cluster purposive sampling was used to conduct a community-based cross-sectional survey for an integrated mapping of LF and podoconiosis, in seven regional states and two city administrations. Two communities in each woreda were purposely selected using the World Health Organization (WHO) mapping strategy for LF based on sampling 100 individuals per community and two purposely selected communities per woreda. Overall, 130 166 people were examined in 1315 communities in 658 woredas. In total, 140 people were found to be positive for circulating LF antigen by immunochromatographic card test (ICT) in 89 communities. Based on WHO guidelines, 75 of the 658 woredas surveyed in the nine regions were found to be endemic for LF with a 2016 projected population of 9 267 410 residing in areas of active disease transmission. Combining these results with other data it is estimated that 11 580 010 people in 112 woredas will be exposed to infection in 2016., Conclusions: We have conducted nationwide mapping of LF in Ethiopia and demonstrated that the number of people living in LF endemic areas is 60% lower than current estimates. We also showed that integrated mapping of multiple NTDs is feasible and cost effective and if properly planned, can be quickly achieved at national scale.

Published
2015
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41. An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys.

Author

Cano J, Moraga P, Nikolay B, Rebollo MP, Okorie PN, Davies E, Njenga SM, Bockarie MJ, and Brooker SJ

Subjects
Animals, Carrier State epidemiology, Elephantiasis, Filarial epidemiology, Humans, Surveys and Questionnaires, Antigens, Helminth isolation & purification, Carrier State blood, Elephantiasis, Filarial blood, Microfilariae isolation & purification, Wuchereria bancrofti isolation & purification
Abstract

Background: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known., Methods: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures., Results and Conclusions: In some settings there was a very large disparity, up to 40-70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed., (© The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2015
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