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2. Post-discharge surgical site infections after uncomplicated elective colorectal surgery: impact and risk factors. The experience of the VINCat Program

Author

Castellana, D., Barcenilla, Fernando, Garcia, G., Antúnez, R., Rebull, J., Domenech, M.F., Domenech, D., Garcia, D., Lérida, A., Martin, L., Oller, B., Sopena, N., Almirante, B., Ferrer, C., Pérez, R., Obradors, F., Mestre, G., Berbel, C., Serrat, P., Palau, E., Iborra, M.I., Zaragoza, M., Garcia, Á., Grabulosa, L., Pericàs, F., Burgas, M.C., Girbal, P., Gonzalez, M., Villegas, M.L., Ferrer, L., Moreno, M.J., Nicolás, C., Navarro, A., Angas, J., Ros, M.T., Smithson, A., Porrón, C., Nolla, M., Rovira, M., Escudero, L.R., Conde, M., Espinosa, J.J., Serrate, G., Falgueras, L., Fernández, I., Cruz, A.J., Ferrer Díaz de Brito, V., Peña, I., Agustí, C., Pagespetit, L., Santamaría, M.A., Rifà, J., Pinyana, A., Herranz, M., Gil, M.J., Beltran, J.M., Sanjurjo, E., Vazquez, R.M., Cuquet, J., Morcillo, M.Á., Hernández, R., Errando, X., Moreno, E., Ferrer, R., Casas, A., Ramos, C., Roura, I., López, A.F., Castro, A., Pérez, À., Espinach, J., Castander, D., Paradiñeiro, J.C., Clarós, M., Jofré, M., Montardit, I., Batlle, R., Cotura, A., Pomar, V., López-Contreras, J., de La Cruz, P., Aguilar, L., Calbet, J., Sabaté, S., Montilla, C., Camps, R., Garcia Penche, R.M., Coll, M.R., Caro, S., Ginesta, D., Doménech, T., Gisbert, J.C., Redón, E., Tricas, J.M., Marrón, A., Brugues, M., Martinez, S., Cuscó, M., Estrada, O., Vidal, E., Roura, J., Colomer, À., Calsina, M., Vaqué, M., Guillemat, M., Armengol, E.C., Vilà, B., Garcia, A., Limón, E., Shaw, E., Badia, J.M., Piriz, M., Escofet, R., Gudiol, F., and Pujol, M.

Published
2014
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3. Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain.

Author

Roso-Llorach, A, Serra-Picamal, X, Cos, FX, Pallejà-Millán, M, Mateu, L, Rosell, A, Almirante, B, Ferrer, J, Gasa, M, Gudiol, C, Moreno, AM, Morales-Rull, JL, Rexach, M, Sabater, G, Auguet, T, Vidal, F, Lerida, A, Rebull, J, Khunti, K, Argimon, JM, Paredes, R, Roso-Llorach, A, Serra-Picamal, X, Cos, FX, Pallejà-Millán, M, Mateu, L, Rosell, A, Almirante, B, Ferrer, J, Gasa, M, Gudiol, C, Moreno, AM, Morales-Rull, JL, Rexach, M, Sabater, G, Auguet, T, Vidal, F, Lerida, A, Rebull, J, Khunti, K, Argimon, JM, and Paredes, R

Abstract

BACKGROUND: The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile and outcome of patients hospitalized with COVID-19 in successive waves of the outbreak. METHODS: We retrospectively analysed the characteristics and in-hospital outcomes of all patients admitted with COVID-19 in eight university hospitals of Catalonia (North-East Spain) between Feb 28, 2020 and Feb 28, 2021. Using a 7-joinpoint regression analysis, we split admissions into four waves. The main hospital outcomes included 30-day mortality and admission to intensive care unit (ICU). FINDINGS: The analysis included 17,027 subjects admitted during the first wave (6800; 39.9%), summer wave (1807; 10.6%), second wave (3804; 22.3%), and third wave (4616; 27.1%). The highest 30-day mortality rate was reported during the first wave (17%) and decreased afterwards, remaining stable at 13% in the second and third waves (overall 30% reduction); the lowest mortality was reported during the summer wave (8%, 50% reduction). ICU admission became progressively more frequent during successive waves. In Cox regression analysis, the main factors contributing to differences in 30-day mortality were the epidemic wave, followed by gender, age, diabetes, chronic kidney disease, and neoplasms. INTERPRETATION: Although in-hospital COVID-19 mortality remains high, it decreased substantially after the first wave and is highly dependent of patient's characteristics and ICU availability. Highest mortality reductions occurred during a wave characterized by younger individuals, an increasingly frequent scenario as vaccination campaigns progress. FUNDING: This work did not receive specific funding.

Published
2022

4. Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain

Author

Universitat Rovira i Virgili, Roso-Llorach A; Serra-Picamal X; Cos FX; Pallejà-Millán M; Mateu L; Rosell A; Almirante B; Ferrer J; Gasa M; Gudiol C; Moreno AM; Morales-Rull JL; Rexach M; Sabater G; Auguet T; Vidal F; Lerida A; Rebull J; Khunti K; Argimon JM; Paredes R, Universitat Rovira i Virgili, and Roso-Llorach A; Serra-Picamal X; Cos FX; Pallejà-Millán M; Mateu L; Rosell A; Almirante B; Ferrer J; Gasa M; Gudiol C; Moreno AM; Morales-Rull JL; Rexach M; Sabater G; Auguet T; Vidal F; Lerida A; Rebull J; Khunti K; Argimon JM; Paredes R

Abstract

Background: The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile and outcome of patients hospitalized with COVID-19 in successive waves of the outbreak. Methods: We retrospectively analysed the characteristics and in-hospital outcomes of all patients admitted with COVID-19 in eight university hospitals of Catalonia (North-East Spain) between Feb 28, 2020 and Feb 28, 2021. Using a 7-joinpoint regression analysis, we split admissions into four waves. The main hospital outcomes included 30-day mortality and admission to intensive care unit (ICU). Findings: The analysis included 17,027 subjects admitted during the first wave (6800; 39.9%), summer wave (1807; 10.6%), second wave (3804; 22.3%), and third wave (4616; 27.1%). The highest 30-day mortality rate was reported during the first wave (17%) and decreased afterwards, remaining stable at 13% in the second and third waves (overall 30% reduction); the lowest mortality was reported during the summer wave (8%, 50% reduction). ICU admission became progressively more frequent during successive waves. In Cox regression analysis, the main factors contributing to differences in 30-day mortality were the epidemic wave, followed by gender, age, diabetes, chronic kidney disease, and neoplasms. Interpretation: Although in-hospital COVID-19 mortality remains high, it decreased substantially after the first wave and is highly dependent of patient's characteristics and ICU availability. Highest mortality reductions occurred during a wave characterized by younger individuals, an increasingly frequent scenario as vaccination campaigns progress. Funding: This work did not receive specific funding.

Published
2022

5. Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season

Author

Soldevila, Núria, Acosta, Lesly, Martínez, Ana, Godoy, Pere, Torner, Núria, Rius i Gibert, Maria Cristina, Jané, Mireia, Domínguez Garcia, Angela, Alsedà, Miquel, Álvarez, Josep, Arias, Chiki, Balaña, Pilar Jorgina, Barrabeig, Irene, Camps, Neus, Carol, Mónica, Ferràs, J., Ferrús, G., Follia, Nuria, Bach, Phuoc, Minguell, Sofia, Parrón, Ignacio, Plasència, Elsa, Sala-Farré, M.R., Torra Balcells, Roser, Torres, J., Marcos, María Ángeles, Mosquera, M.M., Vilella Morato, Anna Maria, Antón, Andrés, Pumarola Suñé, Tomàs, Campins Martí, Magda, García, D., Oller Perez-Hita, A., Espejo, E., Freixas, N., Riera Garcia, M., Maraver, E., Mas, D., Pérez, R., Rebull, J., Pou, J., García-Pardo, G., Olona, M., Barcenilla, F., Castellana, D., Navarro Rubio, Gemma, Force, L., Mòdol-Deltell, J.M., Alvarez, A., Torrel, J.M., Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials

Subjects
Male, 0301 basic medicine, Epidemiology, Pneumònia, Severity of Illness Index, Hospitals -- Ingressos i altes -- Mètodes estadístics, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Medicaments antivírics, Unitats de cures intensives, Aged, 80 and over, Multidisciplinary, biology, Neuraminidase inhibitor, Middle Aged, Intensive Care Units, Matemàtiques i estadística::Estadística aplicada [Àrees temàtiques de la UPC], Infectious diseases, Female, medicine.medical_specialty, medicine.drug_class, Science, Pneumonia, Viral, 030106 microbiology, Neuraminidase, Severe influenza, Antiviral Agents, Article, Grip, 03 medical and health sciences, Internal medicine, Influenza, Human, Severity of illness, Humans, Author Correction, Epidemiologia, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Pneumonia, medicine.disease, Influenza, Risk factors, Spain, biology.protein, Observational study, Influenza virus, business, Ciències de la salut [Àrees temàtiques de la UPC]
Abstract

Altres ajuts: Programme of Prevention, Surveillance and Control of Transmissible Diseases (PREVICET); CIBER de Epidemiología y Salud Pública (CIBERESP). Influenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confirmed influenza during the 2017-2018 season in Catalonia. An observational epidemiological case-to-case study was carried out. Reported cases of severe laboratory-confirmed influenza requiring hospitalization in 2017-2018 influenza season were included. Mixed-effects regression analysis was used to estimate the factors associated with ICU admission and death. A total of 1306 cases of hospitalized severe influenza cases were included, of whom 175 (13.4%) died and 217 (16.6%) were ICU admitted. Age 65-74 years and ≥ 75 years and having ≥ 2 comorbidities were positively associated with death (aOR 3.19; 95%CI 1.19-8.50, aOR 6.95, 95%CI 2.76-1.80 and aOR 1.99; 95%CI 1.12-3.52, respectively). Neuraminidase inhibitor treatment and pneumonia were negatively associated with death. The 65-74 years and ≥ 75 years age groups were negatively associated with ICU admission (aOR 0.41; 95%CI 0.23-0.74 and aOR 0.30; 95%CI 0.17-0.53, respectively). A factor positively associated with ICU admission was neuraminidase inhibitor treatment. Our results support the need to investigate the worst outcomes of hospitalized severe cases, distinguishing between death and ICU admission.

Published
2021
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6. Hospital-acquired influenza infections detected by a surveillance system over six seasons, from 2010/2011 to 2015/2016

Author

Soldevila, N, Dominguez, A, Alseda, M, Alvarez, J, Arias, C, Balana, PJ, Barrabeig, I, Camps, N, Carol, M, Ferras, J, Ferrus, G, Follia, N, Godoy, P, Bach, P, Jane, M, Martinez, A, Minguell, S, Parron, I, Plasencia, E, Sala-Farre, MR, Torner, N, Torra, R, Torres, J, Cayla, J, Gorrindo, P, Rius, C, Marcos, MA, Mosquera, MDM, Vilella, A, Anton, A, Pumarola, T, Campins, M, Garcia, D, Espejo, E, Freixas, N, Garcia, MR, Maraver, E, Mas, D, Perez, R, Rebull, J, Pou, J, Garcia-Pardo, G, Olona, M, Barcenilla, F, Castellana, D, Navarro-Rubio, G, and Force, LL

Subjects
Nosocomial infection, Healthcare-associated infection, Hospitalized patients, Influenza
Abstract

Background In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but are generally not reported in the literature. This study aimed to determine the epidemiologic characteristics of cases of nosocomial influenza compared with the remaining severe cases of severe influenza in acute hospitals in Catalonia (Spain) which were identified by surveillance. Methods An observational case-case epidemiological study was carried out in patients aged >= 18 years from Catalan 12 hospitals between 2010 and 2016. For each laboratory-confirmed influenza case (nosocomial or not) we collected demographic, virological and clinical characteristics. We defined patients with nosocomial influenza as those admitted to a hospital for a reason other than acute respiratory infection in whom ILI symptoms developed >= 48 h after admission and influenza virus infection was confirmed using RT-PCR. Mixed-effects regression was used to estimate the crude and adjusted OR. Results One thousand seven hundred twenty-two hospitalized patients with severe laboratory-confirmed influenza virus infection were included: 96 (5.6%) were classified as nosocomial influenza and more frequently had > 14 days of hospital stay (42.7% vs. 27.7%, P < .001) and higher mortality (18.8% vs. 12.6%, P < .02). The variables associated with nosocomial influenza cases in acute-care hospital settings were chronic renal disease (aOR 2.44 95% CI 1.44-4.15) and immunodeficiency (aOR 1.79 95% CI 1.04-3.06). Conclusions Nosocomial infections are a recurring problem associated with high rates of chronic diseases and death. These findings underline the need for adherence to infection control guidelines.

Published
2020

7. Assessment of two complementary influenza surveillance systems: sentinel primary care influenza-like illness versus severe hospitalized laboratory-confirmed influenza using the moving epidemic method

Author

Torner, N, Basile, L, Martinez, A, Rius, C, Godoy, P, Jane, M, Dominguez, A, Aizpurua, J, Alonso, J, Azemar, J, Aizpurua, P, Ardaya, PM, Basas, MD, Batalla, J, Biendicho, P, Bonet, M, Caliado, M, Campos, S, Casanovas, JM, Ciurana, E, Clapes, M, Cots, JM, De la Rica, D, Domingo, I, Elizalde, G, Escapa, P, Fajardo, S, Fau, E, Fernandez, O, Fernandez, M, Ferrer, C, Forcada, A, Fos, E, Gadea, G, Garcia, J, Garcia, R, Gatius, C, Gelado, MJ, Grau, M, Grive, M, Guzman, MC, Hernandez, R, Jimenez, G, Juscafresa, A, LLussa, AM, Lopez, C, Kristensen, L, Macia, E, Mainou, A, Marco, E, Martinez, M, Martinez, JG, Maruianda, KV, Masa, R, Moncosi, X, Naranjo, MA, Navarro, D, Ortola, E, Paris, F, Perez, MM, Pozo, C, Pujol, R, Ribatailada, A, Ruiz, G, Sabate, S, Sanchez, R, Sarra, N, Tarrago, E, Teixido, AM, Torres, A, Valen, E, Van Esso, D, Van Tarjcwick, C, Schoenholzer, RV, Zabala, E, Marcos, MA, Mosquera, MDM, Rubio, E, Isanta, R, Anton, A, Pumarola, T, Vilella, A, Gorrindo, P, Espejo, E, Andres, M, Barcenilla, F, Navarro, G, Barrabeig, I, Pou, J, Alvarez, P, Plasencia, E, Rebull, J, Sala, MR, Riera, M, Camps, N, Follia, N, Oller, A, Bach, P, Perez, R, Torra, R, Carol, M, Mingueli, S, Marce, R, Garcia-Pardo, G, Olona, M, Alvarez, A, Ramon, JM, Modol, JM, Mena, G, Campins, M, Massuet, C, Tora, G, Ferras, J, and Ferrus, G

Subjects
Hospitalization, Threshold, Epidemic, Sentinel surveillance, Influenza like illness, Influenza, Primary health care
Abstract

Background Monitoring seasonal influenza epidemics is the corner stone to epidemiological surveillance of acute respiratory virus infections worldwide. This work aims to compare two sentinel surveillance systems within the Daily Acute Respiratory Infection Information System of Catalonia (PIDIRAC), the primary care ILI and Influenza confirmed samples from primary care (PIDIRAC-ILI and PIDIRAC-FLU) and the severe hospitalized laboratory confirmed influenza system (SHLCI), in regard to how they behave in the forecasting of epidemic onset and severity allowing for healthcare preparedness. Methods Epidemiological study carried out during seven influenza seasons (2010-2017) in Catalonia, with data from influenza sentinel surveillance of primary care physicians reporting ILI along with laboratory confirmation of influenza from systematic sampling of ILI cases and 12 hospitals that provided data on severe hospitalized cases with laboratory-confirmed influenza (SHLCI-FLU). Epidemic thresholds for ILI and SHLCI-FLU (overall) as well as influenza A (SHLCI-FLUA) and influenza B (SHLCI-FLUB) incidence rates were assessed by the Moving Epidemics Method. Results Epidemic thresholds for primary care sentinel surveillance influenza-like illness (PIDIRAC-ILI) incidence rates ranged from 83.65 to 503.92 per 100.000 h. Paired incidence rate curves for SHLCI -FLU / PIDIRAC-ILI and SHLCI-FLUA/ PIDIRAC-FLUA showed best correlation index' (0.805 and 0.724 respectively). Assessing delay in reaching epidemic level, PIDIRAC-ILI source forecasts an average of 1.6 weeks before the rest of sources paired. Differences are higher when SHLCI cases are paired to PIDIRAC-ILI and PIDIRAC-FLUB although statistical significance was observed only for SHLCI-FLU/PIDIRAC-ILI (p-value Wilcoxon test = 0.039). Conclusions The combined ILI and confirmed influenza from primary care along with the severe hospitalized laboratory confirmed influenza data from PIDIRAC sentinel surveillance system provides timely and accurate syndromic and virological surveillance of influenza from the community level to hospitalization of severe cases.

Published
2019

8. Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype

Author

Martinez, A, Soldevila, N, Romero-Tamarit, A, Torner, N, Godoy, P, Rius, C, Jane, M, Dominguez, A, Alseda, M, Alvarez, J, Arias, C, Balana, PJ, Barrabeig, I, Camps, N, Carol, M, Ferras, J, Ferrus, G, Follia, N, Bach, P, Minguell, S, Parron, I, Plasencia, E, Sala-Farre, MR, Torra, R, Torres, J, Cayla, J, Gorrindo, P, Marcos, MA, Mosquera, MDM, Vilella, A, Anton, A, Pumarola, T, Campins, M, Garcia, D, Espejo, E, Freixas, N, Garcia, R, Maraver, E, Mas, D, Perez, R, Rebull, J, Pou, J, Garcia-Pardo, G, Olona, M, Barcenilla, F, Castellana, D, Navarro-Rubio, G, and Force, LL

Abstract

Seasonal influenza is a cause of hospitalization, especially in people with underlying disease or extreme age, and its severity may differ depending on the types and subtypes of circulating viruses. We investigated the factors associated with ICU admission or death in hospitalized patients with severe laboratory-confirmed influenza according to the viral type and subtype. An observational epidemiological study was carried out in patients aged >= 18 years from 12 Catalan hospitals between 2010 and 2016. For each reported case we collected demographic, virological and clinical characteristics. A mixed-effects logistic regression model was used to estimate crude and adjusted ORs. 1726 hospitalized patients were included: 595 (34.5%) were admitted to the ICU and 224 (13.0%) died. Lower ICU admission was associated with age >= 75 years in all influenza types and subtypes and with age 65-74 years for type A. In contrast, the 65-74 and >= 75 years age groups were associated with an increased risk of death in all types and subtypes, especially for type B (aOR 27.42, 95% CI: 4.95-151.93 and 15.96; 95% CI: 3.01-84.68). The comorbidity most closely associated with severe outcomes was immune deficiency, which was associated with death for type B (aOR 9.02, 95% CI: 3.05-26.69) and subtype A(H1N1)pdm09 (aOR 3.16, 95% CI: 1.77-5.66). Older age was a differential factor for ICU admission and death: it was associated with lower ICU admission but a risk factor for death. The comorbidity with the closest association with death was immune deficiency, mainly in influenza type B patients.

Published
2019

10. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction

Author

Van de Werf, F., Armstrong, P. W., Granger, C., Wallentin, L., Adgey, A. A. J., Aylward, P., Binbrek, A. S., Califf, R., Cassim, S., Diaz, R., Fanebust, R., Fioretti, P. M., Huber, K., Husted, S., Lindahl, B., Lopez-Sendon, J. L., Makijarvi, M., Meyer, J., Navarro Robles, J., Pfisterer, M., Seabra-Gomes, R., Soares-Piegas, L., Sugrue, D., Tendera, M., Theroux, P., Toutouzas, P., Vahanian, A., Verheugt, F., Sarelin, H., Goetz, G., Bluhmki, E., Daclin, V., Danays, T., Houbracken, K., Kaye, J., Reilly, P., Hacke, W., von Kummer, R., Lesaffre, E., Bogaerts, K., Peeters, C., Fox, K. A. A., Brower, R., Hirsh, J., Maggioni, A., Tijssen, J., Weaver, D., Beernaert, A., Beysen, N., Broos, K., De Prins, E., D'Hollander, K., Dupon, L., Fomyna, N., Fransen, A., Genesse, D., Goffin, L., Hendrickx, R., Jansen, B., Jorissen, F., Luys, C., Luyten, A., Marschal, C., Moreira, M., Munsters, K., Salerno, R., Schoovaerts, C., Sinnaeve, P., Schildermans, C., Vandenberghe, K., Vandeschoot, K., Van Gucht, H., Van Rompaey, P., Vlassak, S., Watzeels, M., Wittockx, H., Galan, K., Humeniuk, L., Seidel, A., Molina, M., Hafley, G., Alexander, J., Pascual, A., Bestilny, S., Temple, T., Ahuad Guerrero, R., Albisu, J. P., Bassani Arrieta, C. A., Bono, J., Caccavo, A., Cagnolatti, A., Cartasegna, L. R., Castellanos, R., Chekerdemian, S., Covelli, G., Cuello, J. L., Cuneo, C. A., Fernandez, A., Ferrara, C., Ferro-Queirel, E., Gambarte, A., Garcia-Duran, R., Hasbani, E., Hrabar, A., Keller, L., Lobo Marquez, L. L., Luciardi, H., Macin, S. M., Marinig, A., Marzetti, E., Muntaner, J., Nordaby, R., Orlandini, A. D., Piombo, A. C., Pomposiello, J. C., Quijano, R. A., Amerena, J., Aroney, G., Buckmaster, N., Carroll, P., Fitzpatrick, M., Newman, R., Rowe, M., Singh, B., Thomson, A., Winter, C., Eber, B., Gaul, G. B., Klein, W., Leisch, F., Mayr, H., Mlczoch, J., Niessner, H., Pachinger, O., Pall, H., Pichler, M., Roggla, G., Schaflinger, E., Schreiber, W., Slany, J., Traindl, O., Zenker, G., Beckers, J., Bekaert, I., Berthe, C., Bodur, G., Carlier, B., Carlier, M., Carpentier, J., Celen, H., Charlier, F., Clement, A., Coenen, A., Crochelet, L., De Keyser, F., De Man, F., de Meester, A., Dendale, P., Dhondt, E., Dhooghe, G., El Allaf, D., Elshot, S., Emmerechts, C., Foret, F., Gatera, E., Geraedts, J., Gerardy, A. C., Gysbrechts, M., Hallemans, R., Hellemans, S., Herssens, H., Huygens, L., Janssens, L., Lalmand, J., Maamar, R., Marechal, P., Mertens, D., Michel, P., Morandini, E., Nannan, M., Nguyen, D., Odeurs, W., Peerenboom, P., Pirenne, B., Quinonez, M., Raymenants, E., Renard, M., Silance, P. G., Standaert, A. M., Striekwold, H., Thiels, H., Valadi, D., van Brabandt, H., Van Dormael, M., Van Iseghem, P., Van Walleghem, U., Vanden Bosch, H., Vandenbossche, J. L., Vermylen, J., Verstraete, S., Vo Ngoc, P., Willems, P., Zenner, R., Campos de Albuquerque, D., Coutinho, M., de Camargo Carvalho, A. C., Fernandes Manenti, E. R., Ferreira Azevedo, A., Golin, V., Gun, C., Marin Neto, J. A., Marino, R. L., Miranda Abrantes, J. A., Nicolau, J. C., Porto Alegre Dancini, E. M., Rabelo, A., Ramos, R. F., Rizzi Coelho, O., Alexander, D., Bata, I. R., Bhargava, R. K., Bogaty, P., D'Amours, G., Darcel, I., Finnie, K. J. C., Fowlis, R., Gupta, M. K., Henderson, M., Howlett, M. K., Javier, J. J., Kieu, C. V., Kumar, G., Lebouthillier, P., Leduc, F., Lepage, S., Mcavinue, T., Mcgillen, J. E., Mcmeekin, J. D., Morse, J. W., Pistawka, K., Raimondo, E. F., Sandrin, F., Smith, H., Smylie, P. C., Tran, K., Turabian, M., Wagner, K. R., Winkler, L. H., Woo, K. S., Falstie-Jensen, N., Lind Rasmussen, S., Lomholt, P., Markenvard, J., Nielsen, H., Petersen, J., Romer, F., Ahonen, J., Huttunen, M., Kokkonen, L., Luukkonen, J., Mantyla, P., Melin, J., Mustonen, J., Valli, J., Voutilainen, S., Agraou, B., Allam, S., Baradat, G., Battistella, P., Bazin, P., Bouvier, J. -M., Destrac, S., Fouche, R., Fournier, P. -Y., Funck, F., Garnier, H., Grall, J. -Y., Gully, C., Lallement, P. -Y., Loiselet, P., Mycinsky, C., Page, A., Parisot, M., Range, G., Rocher, R., Tafani, C., Thisse, J. -Y., Tibi, T., Tissot, M., Wahl, P., Backenkohler, U., Bavastro, P., Beckmann-Hiss, H., Behnke, M., Bermes, M., Bernsmeier, R., Bethge, K. P., Bethge, H., Block, M., Burkhardt, W., Cieslinski, G., Claus, G., Deetjen, A., Diefenbach, A., Diehm, C., Dietz, A., Dippold, W. G., Eichner, A., Erckenbrecht, J. F., Gawlick, L., Gerber, V., Goppel, L., Gottwik, M., Grosch, B., Hammer, B., Hanheide, M., Hanrath, P., Haspel, J., Hennersdorf, F., Hermanns, M., Hoffmeister, H. M., Holzapfel, P., Hubner, H., Jansen, W., Jung, S., Kaddatz, J., Kienbock, H., Klein, H. H., Konz, K. H., Kulschbach, M., Leschke, M., Liebau, G., Linnartz, M., Lockert, G., Loesbrock, R., Lollgen, H., Ludwig, N., Mudra, H., Munzer, K., Nebel, B., Nellessen, U., Neu, C., Olbrich, H. G., Pfeffer, A., Pfeiffer, P., Plate, V., Pollock, B., Rapp, H., Rommele, U., Sauer, K., Scheffler, N., Schlotterbeck, K., Schmidt-Salzmann, A., Schnitzler, G., Schumann, H., Schuster, C. J., Schuster, P., Schweizer, P., Seitz, K., Simon, R., Spes, C., Szabo, S., Terhardt-Kasten, E., Theuerkauf, B., Tigges, R., Tinnappel, J., Topp, H., Trockel, P., Unland, N., Veth, V., Vom Dahl, J., Vossbeck, G., Weindel, K., Weib, D., Wiewel, D., Wirtz, P., Zipp, C., Apostolou, T., Chalkidis, C., Exadaktylos, N., Foussas, S., Hatseras, D., Karas, S., Karydis, K., Lambrou, S., Louridas, G., Manolis, A., Nanas, J., Novas, I., Panagiotidou, T., Papadopoulos, C., Papakonstantinou, D., Papasteriadis, E., Pavlidis, P., Pyrgakis, V., Skoufas, P., Stavrati, A., Tyrologos, A., Vardas, P., Vrouchos, G., Zacharoulis, A., Zarifis, J., Brown, A., Daly, K., Fennell, W., Horgan, J., Mccann, H., Mcdonald, K., O'Reilly, M., Sullivan, P., Altamura, G., Ambrosio, G., Auteri, A., Aveta, P., Azzarito, M., Badano, L. P., Barbiero, M., Barletta, C., Biscosi, C., Boccanelli, A., Bottero, M., Brizio, E., Brunazzi, M. C., Brunelli, C., Bugatti, U., Capozi, A., Capucci, A., Carfora, A., Caronna, A., Carrone, M., Casazza, F., Cauticci, A., Ceci, V., Ciconte, V., Circo, A., Ciricugno, S., Comito, F., Cornacchia, D., Corsini, G., D'Andrea, F., De Rosa, P., De Simone, M., Del Citerna, F., Del Pinto, M., Dell'Ali, C., Della Casa, S., Della Monica, R., Delogu, G., Di Biase, M., Di Chiara, A., Di Guardo, G., Di Marco, S., Di Mario, F., Di Napoli, T., Di Palma, F., Fadin, B. M., Fazzari, M., Ferraiuolo, G., Fiaschetti, R., Fontanelli, A., Fresco, C., Gambelli, G., Gasbarri, F., Gemelli, M., Giani, P., Gigantino, A., Giomi, A., Giorgi, G., Greco, C., Gregorio, G., Guagnozzi, G., Guiducci, U., Guzzardi, G., Izzo, A., La Rosa, A., Leone, F., Leone, G., Lo Bianco, F., Locuratolo, N., Maggiolini, S., Malinconico, M., Mancone, C., Mangiameli, S., Marchi, S. M., Maresta, A., Mauri, F., Mazzini, C. A., Michisanti, M., Miracapillo, G., Modena, M. G., Morgagni, G. L., Mossuti, E., Nascimbeni, F., Negrelli, M., Notaristefano, A., Pardi, S., Peci, P., Pettinati, G., Pietropaolo, F., Pirelli, S., Pretolani, M., Prinzi, D., Proietti, F., Raganelli, L., Rapino, S., Re, F., Ricci, R., Rinaldi, G., Rusticali, G., Severi, S., Spallarossa, P., Tartagni, F., Terrosu, P., Tortorella, G., Tota, F., Tritto, I., Tuccilo, B., Turco, V., Uscio, G., Valagussa, F., Vergoni, W., Verzuri, M. S., Vetrano, A., Villani, R., Zanini, R., Boisante, L., Niclou, R., Alcocer, L., Castro, A., Fragoso, J., Gonzalez, V., Gonzalez-Pacheco, H., Hernandez-Santamaria, I., Huerta, R., Huerta, D., Martinez, A., Mendoza, M., Moguel, R., Navarro, J., Portos, J. M., Rodriguez, I., Sierra, L., Valencia, S., Vazquez, A., Arnold, A. E. R., Boehmer, A. G., de Graaf, J. J., Funke Kupper, A. J., Gobel, E. J. A. M., Janus, C. L., Linssen, G. C. M., Sedney, M. I., Slegers, L. C., Spierenburg, H. A. M., Strikwerda, S., Tans, J. G. M., Twisk, S. P. M., van der Heijden, R., van Kalmthout, P. M., Verheugt, F. W. A., Holt, E., Skogsholm, A., Thorshaug, R., Thybo, N. K., Wang, H., Maciejewicz, J., Piotrowski, W., Pluta, W., Ruminski, W., Skura, M., Smielak-Korombel, W., Carranca, J., Carvalho, M., Catarino, C., Cunha, D., Ferreira, D., Ferreira, J., Ferreira da Costa, A. F., Lopes de Carvalho, J., Martins, L., Mourao, L., Oliveira Carrageta, M., Prazeres de Sa, E., Puig, J., Ramalho Dos Santos, M. J. J., Resende, M., Seabra Gomes, R., Baig, M. M. E., Bayat, J., Benjamin, J. D., Ranjith, N., Routier, R., Wittmer, H., Abizanda Campos, R., Alonso Garcia, M. A., Amaro Cendon, A., Arboleda Sanchez, J. A., Blanco Varela, J., Bruguera I Cortada, J., Carpintero Avellaneda, J. L., Caturla Such, J., Civeira Murillo, E., Fernandez Aviles, F., Fernandez Fernandez, R., Figueras Bellot, J., Fiol Sala, M., Froufe Sanchez, J., Garcia Calabozo, R., Garcia Palacios, J. L., Gonzalez Maqueda, I., Kallmeyer Martin, C., Lopez Sendon, J. L., Manzano Ramirez, A., Marine Rebull, J., Monton Rodriguez, A., Pique Gilart, M., Reina Toral, A., Rodriguez Llorian, A., Ruano Marco, M., Sanchez Miralles, A., Sanjose Garagarza, J. M., Santalo Bel, M., Torres Ruiz, J. M., Valentin Segura, V., Ahlstrom, P., Ahremark, U., Bandh, S., Bellinetto, A., Dahlberg, A., Hansen, O., Hurtig, U., Jonasson, L., Karlsson, J. E., Larsson, L. E., Moller, B., Ohlin, H., Persson, H., Sandstedt, L., Soderberg, S., Svennberg, L., Swahn, E., Tygesen, H., Broccard, A. F., Estlinbaum, W., Follath, F., Frutiger, A., Hess, N., Maggiorini, M., Marti, D., Muller, P., Rickenbacher, P., Schaller, M. D., Weinbacher, M., Abdulali, S., Ahmad, G., George, S., Ghazi, A., Rao, K. N., Bishop, A., Bridges, A., Canepa-Anson, R., Cave, M., Clarck, R., Cooper, I., de Belder, A., Farrer, M., Kendall, J. M., Ludman, P., Mattu, R., Mcglinchey, P., Moriarty, A. J., Muthusamy, S., Nee, P. A., Nolan, J., Papouchado, M., Rose, E. L., Shahi, M., Stephens, J., Trevelyan, J., Abdul-Karim, A., Adler, L., Arunasalam, S., Avington, D., Baron, S., Beel, T., Bellamy, B., Bennett, J., Berndt, T., Berrick, A., Bersin, R. M., Bethala, V., Bharath, S., Bouchard, A., Boulet, J. E., Bowerman, R., Boyek, T., Brar, R. S., Brodell, G., Bryant, B., Buckner, J. K., Cage, J., Cannon, J. D., Carducci, B., Carr, K., Chang, M., Chelliah, N., Chin, W. L., Chin, J., Church, D. H., Clark, R., Coulis, L., Dadkhah, S., Dearing, B., Defranco, A., Dharawat, M., Dharawat, R., Dhruva, N., Dicola, J., Dykstra, G., Eisenberg, S., El-Bialy, A., Fera, S., Ford, K., Foreman, R. D., Friedman, S., Friedman, V., Garibian, G., Gelormini, J., Geninatti, M. R., Genovese, R., Ghazi, F., Gilchrist, I., Gitler, B., Glover, R., Gonzalez, J., Goulah, R., Graham, B., Gray, R., Grodman, R., Habib, G. B., Hack, T., Hamroff, G., Hanna, G., Hart, M., Haught, H., Hawkins, J., Hempel, R., Hiremath, Y., Hiser, W., Holland, E., Jaffe, N., Jamal, N., James, K. F., Kalla, S., Kates, M., Kemper, A. J., Kennedy, J. J., Kerut, E. K., Killpack, M., King, J., T. Y., Ko, Kollar, K., Kontos, M., Kugelmassluu, A., Kumar, A., Kutscher, A. H., Lambrecht, C., Lancaster, L., Layden, J., Lazar, A., Lebow, M., Lee, C., Lee, A. B., Lehr, J., Levin, F. L., Levitt, R., Levy, R. M., Lieberman, A., Litman, G. I., Lui, H., Luu, M. Q., Macdonald, G., Madyoon, H., Mancherje, C., Marmulstein, M., Mclaurin, B. T., Mcnellis, M., Mendelson, R., Micale, P. J., Miller, M. J., Miller, M. S., Miller, J., Millman, A., Millsaps, R., Minor, S., Modica, J., Morse, H., Moskovits, N., Nester, B. A., Newton, A. S., Niazi, I., Niederman, A., Oatfield, R., Painter, J. A., Pamfilis, S. M., Pamulapati, K. M., Patel, N., Payne, R., Pearson, C., Peizner, D. S., Petrovich, L., Piriz, J., Pollack, M., Pollock, S., Popkave, A., Puma, J. A., Quesada, R., Quigley-Malcolm, D., Raby, K., Ravindran, K., Rees, A. P., Reiner, J., Rivera, E., Rogers, F., Rosenthal, A., Rowe, W. W., Ryan, P. F., Ryman, K., Salacata, A., Santolin, C., Saucedo, J., Savage, R., Savage, W., Schumacher, R., Segarra, S., Sharkey, S., Shonkoff, D., Silver, M., Silver, S. L., Singh, G., Sinyard, R. D., Sporn, D., Srivastava, N. K., Stomel, R., Suresh, D. P., Tallman, M., Togioka, T., Varma, S., Verant, R. P., Wallach, R., Weinberg, M., Weinberg, D., Weinstein, J. M., Wesley, G., Westerman, J. H., Wheeling, J., Whitaker, J., Widmer, M., Yasin, M., and Zakrzewski, M. J.

Subjects
Male, medicine.medical_specialty, Abciximab, Ischemia, Myocardial Infarction, Tenecteplase, Injections, Immunoglobulin Fab Fragments, Reperfusion therapy, Fibrinolytic Agents, Recurrence, Internal medicine, medicine, Humans, Myocardial infarction, Enoxaparin, Aged, Intention-to-treat analysis, Chi-Square Distribution, business.industry, Heparin, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Survival Analysis, Regimen, Treatment Outcome, Anesthesia, Tissue Plasminogen Activator, Cardiology, Drug Therapy, Combination, Female, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

BACKGROUND: Current fibrinolytic therapies fail to achieve optimum reperfusion in many patients. Low-molecular-weight heparins and platelet glycoprotein IIb/IIIa inhibitors have shown the potential to improve pharmacological reperfusion therapy. We did a randomised, open-label trial to compare the efficacy and safety of tenecteplase plus enoxaparin or abciximab, with that of tenecteplase plus weight-adjusted unfractionated heparin in patients with acute myocardial infarction. METHODS: 6095 patients with acute myocardial infarction of less than 6 h were randomly assigned one of three regimens: full-dose tenecteplase and enoxaparin for a maximum of 7 days (enoxaparin group; n=2040), half-dose tenecteplase with weight-adjusted low-dose unfractionated heparin and a 12-h infusion of abciximab (abciximab group; n=2017), or full-dose tenecteplase with weight-adjusted unfractionated heparin for 48 h (unfractionated heparin group; n=2038). The primary endpoints were the composites of 30-day mortality, in-hospital reinfarction, or in-hospital refractory ischaemia (efficacy endpoint), and the above endpoint plus in-hospital intracranial haemorrhage or in-hospital major bleeding complications (efficacy plus safety endpoint). Analysis was by intention to treat. FINDINGS: There were significantly fewer efficacy endpoints in the enoxaparin and abciximab groups than in the unfractionated heparin group: 233/2037 (11.4%) versus 315/2038 (15.4%; relative risk 0.74 [95% CI 0.63-0.87], p=0.0002) for enoxaparin, and 223/2017 (11.1%) versus 315/2038 (15.4%; 0.72 [0.61-0.84], p

Published
2001

11. Post-discharge surgical site infections after uncomplicated elective colorectal surgery: impact and risk factors. The experience of the VINCat Program.

Author

Limón, E., Shaw, E., Badia, J.M., Piriz, M., Escofet, R., Gudiol, F., Pujol, M., Castellana, D., Barcenilla, Fernando, Garcia, G., Antúnez, R., Rebull, J., Domenech, M.F., Domenech, D., Garcia, D., Lérida, A., Martin, L., Oller, B., Sopena, N., and Almirante, B.

Abstract

Summary: Background: Surgical site infection (SSI) after colorectal procedures represents a measurable quality indicator of a healthcare system. There is an increasing interest in comparing SSI rates between different hospitals and countries: however, the variability of the data regarding the incidence of SSI makes this comparison difficult. For the purposes of evaluation, data collection must be standardized and must include reliable post-discharge surveillance (PDS). Aim: To determine impact and risk factors for PDS SSI after elective colorectal surgery. Methods: VINCat is a nosocomial infection surveillance programme in Catalonia, Spain. Between 2007 and 2011, 52 hospitals joined the programme. Hospitals performed active, prospective, standardized surveillance of elective colorectal resection. PDS was implemented by a multimodal approach and was mandatory within the first 30 days after surgery. Findings: During the study period, 13,661 elective colorectal procedures were included. SSI was diagnosed in 2826 (20.7%) patients, of whom 22.5% during PDS; of these, 52% required readmission. Patients with PDS SSI were younger (odds ratio: 1.57; 95% confidence interval: 1.29–1.91), predominantly female (1.40; 1.16–1.69), had more frequently undergone endoscopic procedures (1.56; 1.30–1.88) and had more incisional SSI (1.88; 1.54–2.28) than patients with in-hospital SSI. Conclusion: SSI rates in elective colorectal procedures at VINCat hospitals were inside the higher range of those reported by other national programmes. PDS SSI increased the overall rate of SSI, had a significant clinical impact, and accounted for almost a quarter of SSI. Younger age and laparoscopic procedures were the most relevant risk factors. Standardized multimodal PDS should be implemented for hospitals performing surveillance of colorectal surgery. [Copyright &y& Elsevier]

Published
2014
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12. Prevalence of infection by carbapenem-resistant Acinetobacter baumannii in Spain (1999-2005) | Prevalencia de infecciones por Acinetobacter baumannii resistente a carbapenemas en España (1999-2005)

Author

Asensio, Á, Cantón, R., Vaqué, J., Calbo-Torrecillas, F., Herruzo, R., Arribas, J. L., Sáenz, Ma C., Torres, M. A., Blasco, P., Garrachón, F., Domínguez, A., Calbo, F., Oña, S., Román, D., Fernández-Crehuet, J., López, F., Varela, R., Pérez Ramírez, M. D., Oliver, S., Martín Ruiz, J. L., Fernández Molle, E., Bajo, J., Zafra, J. A., Dueñas, S., Ramiraz, G., Caballero, C., Lepe, J. A., Sureda, M. D., Chamorro, J., Domínguez, J. M., Galán, M. I., Hernández, M. J., Barrasa, J. I., Pastor, S., Prieto, P., Egido, P., Fernández Gala, T., Prendes, P., Torreblanca, A., Fernández Fuentes, P., Natal, C., Hidalgo, F., Hidalgo, O., Sureda, A. M., Sánchez Gómez, J., López, G., Figuerola, M. A., García Rodríguez, C. M., Barrera, P. E., Hernández Vaquero, V., Gallardo, R. M., Montserrat Blasco, T., Molina, J., Antolín, F. M., Sanz, J. A., Dierssen, T., Muñoz, E., Biurrún, A., Illescas, S., Sánchez Blanqué, M. R., Lizán, M., Hita, A. F., García Puente, E., Juan, S., Sánchez Ruiz, I., Romero, M. C., Gómez, M. M., Vaquero, J. L., Coladas, N., Sanz, L. M., Sanz, M. C., Sáenz, M. C., Vázquez Salvado, M., Fernández Quintana, G., García, A., Lozano, J., Piniella, F., Marcos Pérez, J. A., Robles, E., Carrillo, C., Jiménez, M. M., García Arcal, M. D., Santos, M. I., Martínez, M. S., Magda Campins Martí, Sánchez, J. M., Armadans, L., Trilla, A., Salvia, M. D., Tuyet, J., San Juan, N., Segarra, M., Rosell, F., Latorre, C., Martínez Montauti, J., González Vázquez, M., Casas, I., Esteve, M. G., Espí, A., Fort, I., Serrate, M. G., Gasós, M. A., Corcoy, F., Force, L., Pérez Vidal, R., Marcos, J. M., Esquius, M., García Flores, M. A., Hernández, J. A., Cuquet, J., Vilaró, J., Lizándara, A. M., Vilamala, A., Baucells, J. M., Gavaldá, L., Gené, J., Bisbe, J., García Tejero, C., Matesanz, J., Serna, A. A., Manonelles, A. A., Olona, M., Raga, X., Calbet, J. M., Ballester, F., Sans Mateu, T., Rebull, J., Galbany, J., Cerrillo, A. A., Stoduto, P., Suero, F., Aguirre, P., Benítez Cano, E., Hernández, P., Fernández Naveiro, J. M., Gestal, J. J., Domínguez, V., Rodríguez Mayo, M. D., Posada, M., Uriel, B., Pereira, M. J., Cueto, M., Del Campo, V. M., Fungeiriño, R. M., Quintas, J. C., Alonso, P., Uribe, J., Zorrilla, M. N., Belio, C., García Caballero, J., Asensio, A., Blanco, M. A., Pérez Gorricho, B., Jaén, F., Méndez, J. R., Dávila, F. M., García San José, S., Baquero, M., Díez, R., Vicente, J. A., Gómez, J., Sayalero, T., Pascual, T., Villagrasa, J. R., González Sánchez, M. P., Martín, C., Botía, F., García Henarejos, J. A., Martínez, V., Nicolás, S., López Paredes, A., López Yepes, M., Más Castillo, A., Sainz, J. I., Torres, M., García Jalón, J., Sábada, B., Hernández Galve, A., Segarra, L., Castellano, E., Ortí, R., Llucián, R., Tejeda, M., Zanón, V., Pérez, D. M., Torres, M. J., Sánchez Payá, J., Navarro, J. F., González Torga, A. A., Aparicio, T., López Lozano, J. M., Castañ, C., Brau, J., Pardo, F. J., Novales, J. L., Sáenz Domínguez, J. R., Arévalo, J. M., Núñez, R., Elósegui, M., Gómez, H., Carrandi, B., Villate, J. I., Arroyo, M. J., Elorduy, L., Martín, G., Canduela, C., Collado, F. J., Cabarcos, A., and Riaño, V.

13. Lights and shadows in patient safety: Study and development of strategies. 2008 SESPAS Report | Luces y sombras en la seguridad del paciente: Estudio y desarrollo de estrategias. Informe SESPAS 2008

Author

Aranaz-Andrés, J. M., Limón-Ramírez, R., Aibar-Remón, C., Miralles-Bueno, J. J., Vitaller-Burillo, J., Terol-García, E., Castro, M. T. G. -V, Requena-Puche, J., Rey-Talens, M., Infante, A., Polo, M. P., Terol, E., Casal, J. M., Sierra, E., García, M. J., Agra, Y., Palanca, I., Vitaller, J., Zarco, A., Soro, C., Ivorra, F. M., Bartolomé, F., Gómez, J. A., Agulló, V., Montesinos, M. A., García, J. R., Aguado, L. R., Cortés, M. P., Misiego, A., Jiménez, L., Villaverde, M. V., Abadía, M. B., Ceballos, C., García, E. E., La Hoz, C. A., Jaén, P., Lechuga, L., Rebull, J., Brull, Ll, Gombáu, C., Doménech, M. F., Gómez, F., Becerra, D., Donate, C., Valero, C., Martínez, M. D., Ansede, J. C., Albeniz, C., Arias, S., Carrión, M., Lobote, M., Vadillo, P., Lameiro, F. J., Jáuregui, M. A., Sarasa, I., Silvestre, C., Cots, F., Lasso, C., García, P., Bartolomé, N., Del Campo, V., Felpeto, I., Guimarey, R. M., Homs, E., Durany, M., Quintana, M., Monteis, J., Valenzuela, J. C., Díaz, M., Calonge, M. L., Valledor, M., Martín, M. T., Jiménez, R. M., Cabrera, A., Murcia, M. J., Blasco, S., Sánchez-Porro, A., Gámez, M. V., Calle, F., Biurrun, A., León, E., Ovejero, A. F., Martínez, R., Rivas, M., Tormo, A., Gómez-Alférez, C., Enríquez, F., Cabello, J. A., Pérez, D., López, L., Amor, J. F., Gómez, A., Martínez, J., Celorrio, J. M., Clemente, M. E., García, M. C., Orobitg, J., Gaig, M. T., Viciosa, M., Del Río, P., Capetillo, M. P., Cuesta, S., Martínez, A., Berrozpe, E. M., Aranaz, V., Miralles, J. J., García, R., Fernández, E., Moris La Tassa, J., Barceló, F. X., Herrera, P., Fernández, J., García, J. M., Torralba, Ll, Blanco, M. A., Pajuelo, J. M., Rey, J., Pardo, A., Paredes, J., Idoate, M. F., Darpón, J., Marc Carreras, and Meneu, R.

14. A critical aspect of quality. The adverse events in Spanish hospitals: The results of ENEAS study | Un aspecto crítico de la calidad: Los sucesos adversos en los hospitales españoles: Resultados del estudio eneas

Author

Aranaz, J. M., Aibar, C., Casal, J., Gea, M. T., Limón, R., Requena, J., Miralles, J. J., García, R., Mareca, R., Infante, A., Polo, M. P., Terol, E., Sierra, E., García, Ma J., Agra, Y., Palanca, I., Zarco, A., Soro, C., Ivorra, F. M., Bartolomé, F., Gómez, J. A., Agulló, V., Montesinos, Ma A., García, J. R., Aguado, L. R., Cortés, Ma P., Misiego, A., Jiménez, L., Villaverde, M. V., Abadía, M. B., Ceballos, C., García, E. E., La Hoz, C. A., Jaén, P., Lechuga, L., Rebull, J., Brull, Ll, Gombáu, C., Doménech, M. F., Gómez, F., Becerra, D., Donate, C., Valero, C., Martínez, Ma D., Ansede, J. C., Albeniz, C., Arias, S., Carrion, M., Lobote, M., Vadillo, P., Lameiro, F. J., Jáuregui, Ma A., Sarasa, I., Silvestre, C., Cots, F., Lasso, C., García, P., Bartolomé, N., Del Campo, V., Felpeto, I., Guimarey, R. Ma, Homs, E., Durany, M., Quintana, M., Monteis, J., Valenzuela, J. C., Díaz, M., Calonge, Ma L., Valledor, M., Martín, Ma T., Jiménez, R. Ma, Cabrera, A., Murcia, Ma J., Blasco, S., Sanchez-Porro, A., Gámez, Ma V., Calle, F., Biurrun, A., León, E., Ovejero, A. F., Martínez, R., Rivas, M., Tormo, A., Gómez-Alférez, C., Enríquez, F., Cabello, J. A., Pérez, D., López, L., Amor, J. F., Gómez, A., Martínez, J., Celorrio, J. M., Clemente, Ma E., García, Ma C., Orobitg, J., Gaig, Ma T., Viciosa, M., Del Rio, P., Capetillo, Ma P., Cuesta, S., Martínez, A., Berrozpe, E. Ma, Ruiz, P., Vitaller, J., Ricci, A., Fernández, E., La Tassa, J., Barceló, F. X., Herrera, P., Fernández, J., García, J. M., Torralba, L., Blanco, Ma A., Pajuelo, J. M., Rey, J., Pardo, A., Paredes, J., Idoate, M. F., Darpón, J., Marc Carreras, and Meneu, R.

15. Lights and shadows in patient safety: Study and development of strategies. 2008 SESPAS Report,Luces y sombras en la seguridad del paciente: Estudio y desarrollo de estrategias. Informe SESPAS 2008

Author

Jesús María Aranaz Andrés, Limón-Ramírez, R., Aibar-Remón, C., Miralles-Bueno, J. J., Vitaller-Burillo, J., Terol-García, E., Castro, M. T. G. -V, Requena-Puche, J., Rey-Talens, M., Infante, A., Polo, M. P., Terol, E., Casal, J. M., Sierra, E., García, M. J., Agra, Y., Palanca, I., Vitaller, J., Zarco, A., Soro, C., Ivorra, F. M., Bartolomé, F., Gómez, J. A., Agulló, V., Montesinos, M. A., García, J. R., Aguado, L. R., Cortés, M. P., Misiego, A., Jiménez, L., Villaverde, M. V., Abadía, M. B., Ceballos, C., García, E. E., La Hoz, C. A., Jaén, P., Lechuga, L., Rebull, J., Brull, Ll, Gombáu, C., Doménech, M. F., Gómez, F., Becerra, D., Donate, C., Valero, C., Martínez, M. D., Ansede, J. C., Albeniz, C., Arias, S., Carrión, M., Lobote, M., Vadillo, P., Lameiro, F. J., Jáuregui, M. A., Sarasa, I., Silvestre, C., Cots, F., Lasso, C., García, P., Bartolomé, N., Del Campo, V., Felpeto, I., Guimarey, R. M., Homs, E., Durany, M., Quintana, M., Monteis, J., Valenzuela, J. C., Díaz, M., Calonge, M. L., Valledor, M., Martín, M. T., Jiménez, R. M., Cabrera, A., Murcia, M. J., Blasco, S., Sánchez-Porro, A., Gámez, M. V., Calle, F., Biurrun, A., León, E., Ovejero, A. F., Martínez, R., Rivas, M., Tormo, A., Gómez-Alférez, C., Enríquez, F., Cabello, J. A., Pérez, D., López, L., Amor, J. F., Gómez, A., Martínez, J., Celorrio, J. M., Clemente, M. E., García, M. C., Orobitg, J., Gaig, M. T., Viciosa, M., Del Río, P., Capetillo, M. P., Cuesta, S., Martínez, A., Berrozpe, E. M., Aranaz, V., Miralles, J. J., García, R., Fernández, E., Moris La Tassa, J., Barceló, F. X., Herrera, P., Fernández, J., García, J. M., Torralba, Ll, Blanco, M. A., Pajuelo, J. M., Rey, J., Pardo, A., Paredes, J., Idoate, M. F., Darpón, J., Carreras, M., and Meneu, R.

16. Effects of intermittent exposure to hypobaric hypoxia and cold on skeletal muscle regeneration: Mitochondrial dynamics, protein oxidation and turnover.

Author

Sánchez-Nuño S, Santocildes G, Rebull J, Bardallo RG, Girabent-Farrés M, Viscor G, Carbonell T, and Torrella JR

Subjects
Animals, Rats, Male, Proteasome Endopeptidase Complex metabolism, Rats, Wistar, Mitochondria, Muscle metabolism, Muscle, Skeletal metabolism, Oxidation-Reduction, Regeneration, Hypoxia metabolism, Mitochondrial Dynamics, Cold Temperature, Nitric Oxide Synthase Type III metabolism, Nitric Oxide Synthase Type III genetics
Abstract

Muscle injuries and the subsequent regeneration events compromise muscle homeostasis at morphological, functional and molecular levels. Among the molecular alterations, those derived from the mitochondrial function are especially relevant. We analysed the mitochondrial dynamics, the redox balance, the protein oxidation and the main protein repairing mechanisms after 9 days of injury in the rat gastrocnemius muscle. During the recovery rats were exposed to intermittent cold exposure (ICE), intermittent hypobaric hypoxia (IHH), and both simultaneous combined stimuli. Non-injured contralateral legs were also analysed to evaluate the specific effects of the three environmental exposures. Our results showed that ICE enhanced mitochondrial adaptation by improving the electron transport chain efficiency during muscle recovery, decreased the expression of regulatory subunit of proteasome and accumulated oxidized proteins. Exposure to IHH did not show mitochondrial compensation or increased protein turnover mechanisms; however, no accumulation of oxidized proteins was observed. Both ICE and IHH, when applied separately, elicited an increased expression of eNOS, which could have played an important role in accelerating muscle recovery. The combined effect of ICE and IHH led to a complex response that could potentially impede optimal mitochondrial function and enhanced the accumulation of protein oxidation. These findings underscore the nuanced role of environmental stressors in the muscle healing process and their implications for optimizing recovery strategies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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17. Application of HPLC-UV combined with chemometrics for the detection and quantification of 'true cinnamon' adulteration.

Author

Pages-Rebull J, Sagristà G, Pérez-Ràfols C, Serrano N, and Díaz-Cruz JM

Subjects
Chromatography, High Pressure Liquid methods, Chemometrics, Coumarins analysis, Cinnamomum zeylanicum, Eugenol
Abstract

Cinnamon is one of the most popular spices used in cuisines worldwide. Among its different species, Ceylon cinnamon ("true cinnamon") is the one with the most health benefits due to its high concentration in the antioxidant eugenol and the ultra-low content of the hepatotoxic compound coumarin. However, the higher price of Ceylon cinnamon makes it vulnerable to fraudulent adulteration with more economic species of cinnamon, such as Cassia and Saigon. Thus, for the detection of frauds in cinnamon samples, a HPLC-UV method was developed for the determination of 4 characteristic cinnamon compounds: eugenol, cinnamaldehyde, coumarin and cinnamic acid. The obtained data were analyzed by PLS to attain not only the authentication of cinnamon species but also the detection and quantification of partial adulterations. Several mixtures prepared in the laboratory using different cinnamon powder samples considered 'pure' Ceylon, Cassia or Saigon were tested, concluding that the proposed approach allows a clear identification of Ceylon cinnamon and a suitable quantification of the Ceylon: non-Ceylon ratio regardless of the commercial sample selected (RMSE <0.06 for both training and test sets)., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2024
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18. Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain.

Author

Roso-Llorach A, Serra-Picamal X, Cos FX, Pallejà-Millán M, Mateu L, Rosell A, Almirante B, Ferrer J, Gasa M, Gudiol C, Moreno AM, Morales-Rull JL, Rexach M, Sabater G, Auguet T, Vidal F, Lerida A, Rebull J, Khunti K, Argimon JM, and Paredes R

Abstract

Background: The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile and outcome of patients hospitalized with COVID-19 in successive waves of the outbreak., Methods: We retrospectively analysed the characteristics and in-hospital outcomes of all patients admitted with COVID-19 in eight university hospitals of Catalonia (North-East Spain) between Feb 28, 2020 and Feb 28, 2021. Using a 7-joinpoint regression analysis, we split admissions into four waves. The main hospital outcomes included 30-day mortality and admission to intensive care unit (ICU)., Findings: The analysis included 17,027 subjects admitted during the first wave (6800; 39.9%), summer wave (1807; 10.6%), second wave (3804; 22.3%), and third wave (4616; 27.1%). The highest 30-day mortality rate was reported during the first wave (17%) and decreased afterwards, remaining stable at 13% in the second and third waves (overall 30% reduction); the lowest mortality was reported during the summer wave (8%, 50% reduction). ICU admission became progressively more frequent during successive waves. In Cox regression analysis, the main factors contributing to differences in 30-day mortality were the epidemic wave, followed by gender, age, diabetes, chronic kidney disease, and neoplasms., Interpretation: Although in-hospital COVID-19 mortality remains high, it decreased substantially after the first wave and is highly dependent of patient's characteristics and ICU availability. Highest mortality reductions occurred during a wave characterized by younger individuals, an increasingly frequent scenario as vaccination campaigns progress., Funding: This work did not receive specific funding., Competing Interests: KK is a member of the UK Scientific Advisory Group for Emergencies. The rest of the authors have no conflicts of interest to declare., (© 2022 Published by Elsevier Inc.)

Published
2022
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21. [Dogmatil in schizophrenic psychoses. New clinico-therapeutic aspect].

Author

Planas Casas P and Baques Rebull J

Subjects
Adolescent, Adult, Antidepressive Agents administration & dosage, Antidepressive Agents adverse effects, Child, Child, Preschool, Evaluation Studies as Topic, Humans, Middle Aged, Pyrrolidines administration & dosage, Pyrrolidines adverse effects, Pyrrolidines therapeutic use, Sulfonamides administration & dosage, Sulfonamides adverse effects, Antidepressive Agents therapeutic use, Schizophrenia drug therapy, Sulfonamides therapeutic use
Published
1972

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