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Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To describe the long-term health outcomes of neonates affected by necrotizing enterocolitis (NEC) and its implications for quality of life. Data source: This is an integrative review, conducted by searching the literature in the following databases: Virtual Health Library (BVS), Latin American and Caribbean Health Sciences Literature (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE), and PubMed, using Health Sciences Descriptors (DeCS): “necrotizing enterocolitis,” “quality of life,” and “prognosis” combined with the Boolean operators AND and OR: “quality of life” OR “prognosis.” Inclusion criteria were: publication period between 2012 and 2022. Data synthesis: A total of 1,010 studies were located, of which ten were selected to comprise the bibliographic sample of this review. Children with NEC are prone to exhibit cognitive neurological impairment, especially those who undergo surgical procedures due to more severe conditions. Motor development was considered below average when compared to healthy children, with more noticeable delays in fine and gross motor function development. The search for the relationship between NEC and quality of life revealed that this condition has a negative impact on the wellbeing of affected individuals. Conclusions: NEC has proven to be a serious condition contributing to high rates of morbidity and mortality in newborns, potentially leading to a reduction in the quality of life of affected patients. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introdução: Diante das particularidades e desafios no manejo e tratamento de feridas em recém-nascidos torna-se importante para o enfermeiro conhecer, indicar e avaliar a eficácia e segurança das coberturas e produtos, inclusive na análise dos produtos para o público neonatal. Objetivo: Identificar na literatura as principais coberturas e produtos utilizados no tratamento de feridas em recém-nascidos. Metodologia: Trata-se de uma revisão integrativa de literatura, com artigos publicados entre os anos de 2018 a 2022, que abordaram os temas de coberturas e produtos utilizados no tratamento de feridas em recém-nascidos. A coleta de dados foi realizada por meio de consulta na Biblioteca Virtual de Saúde e Scientific Eletronic Library Online. Foram utilizados os descritores “newborn”, “wounds” e “bandage”. A análise foi realizada conforme a estratégia PICO e estruturados pelo PRISMA. Resultados: Diante dos achados foi possível identificar 13 artigos que abordavam produtos e coberturas destinados ao tratamento de feridas em neonatos. Foram encontrados 14 tipos de coberturas/produtos e dispositivos que utilizam a terapia por pressão negativa. Considerações finais: A literatura indica o uso de produtos e cobertura com princípios passivos, ativos e biológicos para o tratamento de feridas em neonatos, inclusive no prematuro, valendo destacar a importância em considerar o uso seguro de coberturas adequadas a esse público.

Os cuidados destinados aos recém-nascidos prematuros extremos têm propiciado importantes resultados na sobrevida dessas crianças. Objetivo: Caracterizar o perfil de morbidade no primeiro ano de vida entre recémnascidos de alto risco. Materiais e Métodos: Trata-se de uma pesquisa exploratória realizada no ambulatório de seguimento de recém-nascidos de alto risco do norte de Minas Gerais. A coleta de dados foi referente às admissões no período de março de 2014 a abril de 2015. O instrumento contemplava características: demográficas, sociais, condições de gestação e parto, intercorrências no pós-parto e condições de saúde das crianças acompanhadas ao longo do primeiro ano de vida. Realizou-se a análise estatística descritiva e o teste Qui-Quadrado, assumindo-se um nível de significância de 5% para comparação da distribuição das morbidades por faixas de peso. Resultados: Participaram deste estudo 282 recém-nascidos, sendo 53,9% do sexo masculino. Entre as mães, 58,2% era multípara e 35,8% hipertensas. Em relação ao peso de nascimento, 59,6% dos recém-nascidos acompanhados pesaram menos de 1500 gramas. As principais morbidades identificadas no primeiro ano de vida foram atraso do desenvolvimento neuro-psicomotor, infecções de vias aéreas superiores, as alterações neurológicas e as afecções respiratórias crônicas. Foram registradas diferenças estatisticamente significantes para o atraso do desenvolvimento neuro-psico-motor (p

Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Physiotherapy Research / Revista Pesquisa em Fisioterapia is the property of Journal of Physiotherapy Research / Revista Pesquisa em Fisioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos Latinoamericanos de Nutrición is the property of Sociedad Latinoamericana de Nutricion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

O presente estudo teve o propósito de explorar a perceção de uma equipa de enfermeiros de saúde materna e obstetrícia relativamente à experiência na atuação em situações de risco e perigo em recém-nascidos. Para tal, realizou-se uma investigação de caráter qualitativo e desenho transversal. Foram entrevistados 19 enfermeiros de um serviço de saúde materna e obstetrícia com idades compreendidas entre os 29 e os 56 anos, com experiência profissional na área entre os seis meses e 26 anos. A recolha de dados foi feita através de um questionário sociodemográfico e um guião de entrevista semiestruturado composto por questões abertas. Os resultados sugerem os critérios pelos quais os enfermeiros entrevistados avaliam as situações de risco e perigo, bem como as emoções experienciadas e o papel atribuído à formação neste âmbito. Conclui-se que pode ser importante o investimento na qualificação específica destes profissionais de modo a contribuir para aprimorar a intervenção neste domínio.

This study aimed to explore the perception of a team of maternal health nurses and obstetrics concerning the experience in working in situations of risk and danger to newborns. For this, a qualitative and cross-sectional research was conducted. Nineteen nurses from a team of a maternal health and obstetrics service were interviewed. Nurses were aged between 29 and 56 years, and had professional experience in the area between six months and 26 years. Data collection was performed through a sociodemographic questionnaire and semi--structured interview guide with open questions. The results suggest the criteria by which the interviewed nurses assess risk and danger situations, the experienced emotions, as well as the role attributed to training in this area. It is concluded that it may be important to invest in the specific qualification of these professionals to improve intervention in this domain. [ABSTRACT FROM AUTHOR]

Objectives: (a) To determine the 3rd, 50th, and 97th percentiles of weight, length, and head circumference of newborns from the Ribeirão Preto BRISA cohort, according to gender and gestational age, and compare them with the Intergrowth‐21st standard; (b) To estimate the small for gestational age ( 97th percentile), stunting (length 1 cm, and full‐term and post‐term newborns showed a variation of percentil 97), stunting (comprimento < percentil 3) e waisting (índice de massa corporal < percentil 3). Método: Estudo observacional de uma coorte de 7.702 recém‐nascidos entre 01/01 e 31/12/2010 na cidade de Ribeirão Preto, SP, Brasil. Os percentis 3, 50 e 97 para as medidas antropométricas foram determinados com regressão polinomial fracionária. Resultados: A diferença de peso entre Ribeirão Preto e Intergrowth‐21st foi pequena, mais acentuada nos recém‐nascidos pré‐termo (diferença média entre as duas populações foi de + 266 gramas); para os recém‐nascidos a termo a diferença média foi de + 66 gramas e para os pós‐termo de ‐113 gramas. Para comprimento, a variação média foi sempre < 1 cm; enquanto que para perímetro cefálico os recém‐nascidos pré‐termo apresentaram variação > 1 cm e os recém‐nascidos a termo e pós‐termo tiveram variação < 1 cm. As taxas de detecção de pequeno e grande para idade gestacional foram 2,9% e 4,3%, respectivamente. Stunting afetou 6,5% de todos os recém‐nascidos e waisting 1,5%, com predomínio em meninas e em gestações a termo; ambas as condições estavam presentes em 0,4% da amostra. Conclusões: Os recém‐nascidos de Ribeirão Preto, quando comparados com o padrão Intergrowth‐21st, apresentam‐se mais pesados, mais longos e com maior circunferência craniana até chegarem a termo.

Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Contexto e Objetivo: Este estudo visa perceber as vivências das mães de recém-nascidos em risco e perigo na perspetiva de uma equipa de enfermagem de saúde materna e obstetrícia. Método: realizou-se uma investigação de caráter qualitativo e desenho transversal, na qual participaram dezanove enfermeiros de saúde materna e obstetrícia. A recolha de dados foi feita através de um questionário sociodemográfico e um guião de entrevista semiestruturado composto por questões abertas. Resultados: Na perspetiva dos enfermeiros entrevistados, o percurso de vida das mães de recém-nascidos em risco e perigo apresenta um acumular de acontecimentos desafiantes, que em alguns casos pode afetar os cuidados maternos e em consequência o desenvolvimento do recém-nascido. Além disso, segundo os enfermeiros entrevistados, as mães lidam com a avaliação das situações de risco e perigo, sobretudo, com receio de separação do recém-nascido. Apesar disso, consideram que, na maioria das vezes, a colaboração para o trabalho profissional é positiva. Conclusões: É necessária uma avaliação e intervenção precoces por parte dos profissionais que acompanham estas mães e famílias, tendo em vista as necessidades dos recém-nascidos para evitar a perpetuação das situações de risco e perigo.

Copyright of Journal of Nursing UFPE / Revista de Enfermagem UFPE is the property of Revista de Enfermagem UFPE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Niemann-Pick disease (NPD) is a rare, lysosomal storage or accumulation disorder. It is considered a serious disease and has three main types: A, B and C. This study aims to analyze whether the presentation of clinical manifestations in a certain age group of type C of the disease influences the improvement of the diagnosis and the patient's prognosis. This study uses the integrative literature review as a method, carried out by searching the Virtual Health Library (VHL) in the Medline, Pubmed and Scielo (Scientific Electronic Library Online) databases using the intersections of the descriptors "Disease Niemann-Pick", "Newborns". The clinical spectrum varies from a fatal prenatal disease to a chronic neurodegenerative disease in the adult stage. Neonates may have ascites and hepatomegaly, and may be associated with breathing difficulty due to infiltration of the lungs. Due to the complexity of the presentation of symptoms, the diagnosis of NPC represents a great challenge, and the recognition of symptoms and diagnosis are crucial for the early initiation of specific therapies of the disease, ensuring better results for patients. In order to improve diagnosis and facilitate early intervention, a neonatal screening assay based on recently identified plasma bile acid biomarkers has been developed. Considering the prevalence of symptoms in the diagnosis in patients of different ages and highlighting possible correlations between symptoms, professionals can obtain valuable information about the symptoms of NPC, helping in the recognition of patients with NPC in a certain age group. [ABSTRACT FROM AUTHOR]

Objective: This paper aims to analyze the use of off label (OL) medicines, according to the National Regulatory Agency, in a neonatal intensive care unit of a high-risk maternity hospital in Northeast Brazil. Methods: A cross-sectional study was carried out, using a convenience sample of newborns that used mechanical ventilation at the Intensive Care Unit. As a reference, OL medications were considered for those without an approval for newborn usage by the Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária - ANVISA) and by the Food and Drugs Administration (FDA). Results: The sample consisted of 158 newborns, 58.3% male, 87.7% premature, and 70.2% of low or very low birth weight. According to ANVISA, 440 out of the 1,167 prescriptions analyzed were OL, with 98.1% of newborns exposed to at least one of these drugs. According to the FDA, 484 prescriptions were OL, with 75.8% of newborns exposed to at least one of them. Anti-infectives were the most prescribed OL medications. Neonates who presented respiratory failure and pneumonia used these drugs more often; and there was no relation between their use and the number of deaths. Conclusions: Nearly all newborns at the Intensive Care Units, mainly preterm infants, are exposed to at least one off-label (OL) medication during hospital stay, according to the national and international regulatory agencies. No association was found between off-label prescriptions and the frequency of complications or neonatal deaths. [ABSTRACT FROM AUTHOR]

O presente artigo tem como objetivo realizar um estudo envolvendo as intervenções cirúrgicas realizadas em intersexuais recém-nascidos e a mediação sanitária. Utilizar-se-ão os métodos hipotético-dedutivo, hermenêutico e argumentativo, em vertente jurídico-sociológica e jurídico-projetiva. Em primeira abordagem, faz-se um breve escorço acerca dos intersexuais e seu direito à existência. Em seguida, as questões envolvendo o direito ao corpo e à saúde, bem como a possibilidade de mediação sanitária, serão aventados. Ao final, serão apresentadas as conclusões. This paper aims to conduct a study involving surgical interventions performed on newborn intersexuals and health mediation. The hypothetical-deductive, hermeneutic and argumentative methods will be used, in the juridical-sociological and juridical-projective way. In the first approach, a brief foreshortening is made about intersexuals and their right to exist. Then, issues involving the right to body and health, as well as the possibility of mealth mediation, will be raised. At the end, the conclusions will be presented.

Objective: To analyze the efficacy in the process of blood collection and processing of newborns for biological neonatal screening. Methods: A retrospective, descriptive and cross-sectional study using secondary data from the Mato Grosso neonatal screening reference service. The survey was conducted in ten municipalities of the Garças-Araguaia region between 2013 and 2016. Results: It was observed that only one municipality achieved the full coverage of live births, as recommended by the National Program of Neonatal Screening. The other municipalities had a coverage below the national average (76.9%). The failures identified in the blood collection process during biological neonatal screening were inadequate samples, such as diluted samples and insufficient material. Conclusion: The need for adequate capacity-building through continuing education is emphasized in order to expand the technical-scientific knowledge of the health professionals involved in biological neonatal screening. The intervention and early identification of diseases is also emphasized, reducing the risk of sequelae, and ensuring the improvement in the baby's quality of life and care provided to the population. [ABSTRACT FROM AUTHOR]

Occupational safety measures, aiming at the biopsychosocial integrity of the individual, were necessary for the development of norms that would lead to the minimization of occupational hazards existing in the workplace. Based on this context, the present study presented an analysis of cognitive ergonomics, among which the present risks, which influence the research. The aspects that compose cognitive ergonomics, be it memory, perception, reasoning and motor response, allow interferences in the development of nurses' care practices, leading the study to the understanding that this ergonomics contributes to psychosocial risks and, consequently, occupational risks. Therefore, through this reality that was raised by the research, it is proposed the commitment to direct the educational process to the nursing scope, in order to overcome the challenges that permeate the care in the hemodialysis clinic. [ABSTRACT FROM AUTHOR]

Objective:To analyze the profile of the eye test in a reference institution in the State of Paraíba, and to identify the municipalities that refer their patients, prevalence of care and distribution of the test according to age and gender. Method:Documentary research, retrospective, descriptive research with quantitative approach. Data collection involved all newborn care (newborns), population of 418 patients. Inclusion criteria were newborns born or referred to the locus of the research, both sexes. Newborns born outside the period from January to December 2018 were excluded. Data collection occurred at the ophthalmology service, including variables such as: date of examination, city of origin of the newborn, age, sex, monthly quantity and test result. Results: The most prevalent city of origin was Santa Luzia (42.58%), with regard to age showing a higher rate in the age group of 1 to 2 months (64.83%). Regarding gender, males were in greater proportion (50.96%). Regarding the months, November had the highest prevalence (15.31%). Regarding the diagnoses, the red reflex test was present in 100% (n = 418). Conclusion: The service was able to trace and analyze the profile of pediatric patients who underwent the red reflex test, which had their satisfactory results, yet it was crucial in the possibility of early, effective and safe treatment, with their cognitive and physical development assured. The consolidation of the action of the service strengthens the program and involvement of the multiprofessional team, bringing improvement, learning and salud ocular. [ABSTRACT FROM AUTHOR]

Copyright of Jornal de Pediatria is the property of Sociedade Brasileira de Pediatria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of the present study is to describe the typical profile of post-natal women and newborn children (NB) in the municipality of Ji-Paraná/RO between in 2014 - 2018. This was a descriptive, retrospective and epidemiologic study, with a quantitative approach, using secondary data, registered with the SINASC and made available by epidemiological surveillance of the town. Based on the results, most mothers presented an average age of 25 and 26 years, were married, on brown race and color and had studied for 8 years or over. The majority childbirths occurred in hospital, there was a predominance of cesarean rates and in the number of male NB births; the percentage of low birth weight was similar to data presented in other studies had in Brazil; among the lives births the full term newborns and single pregnancy were predominant. As well, the number of prenatal consultations increased improving the quality of assistance provided. [ABSTRACT FROM AUTHOR]

This article analyzes the incidence, causes, and outcomes of unplanned extubation (UE) in newborns admitted to the Neonatal Intensive Care Unit of the Clinical Hospital of the Federal University of Uberlândia. The study included 40 cases of UE, with an incidence of 1.11 UE/100 days of intubation. UE was more common in extremely premature infants with a mechanical ventilation time of more than 7 days. The main cause of UE was psychomotor agitation, and the majority of newborns were not sedated and needed to be reintubated. [Extracted from the article]

This article is an integrative literature review that evaluates the effects of the Thoracoabdominal Rebalancing Method (RTA) in the neonatal population with respiratory dysfunctions. The research was conducted using the SciELO, MedLine, and LILACS databases, and the selected articles showed that RTA techniques generate positive changes in signs of respiratory effort, cardiorespiratory parameters, respiratory biomechanics, and other factors, providing a better quality of life for neonates. In some studies, RTA demonstrated superiority over conventional techniques. It is concluded that RTA is safe and effective in the treatment of neonates, but further studies on the method and its effects, including other populations, are needed. [Extracted from the article]

Copyright of Journal of Nursing UFPE / Revista de Enfermagem UFPE is the property of Revista de Enfermagem UFPE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Brazilian Journal of Occupational Therapy / Cadernos Brasileiros de Terapia Ocupacional is the property of Cadernos de Terapia Ocupacional da UFSCar and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introdução: O leite materno é o alimento ideal nos primeiros 6 meses de vida. O início e manutenção do aleitamento materno (AM) dependem de múltiplos fatores. Pretendeu-se conhecer a prevalência do AM logo após o nascimento, aos 3 e 6 meses, avaliar os fatores determinantes do seu início e manutenção. Material e Métodos: Estudo longitudinal prospetivo, que incluiu 60.2% dos recém-nascidos (RN) nascidos de fevereiro a abril de 2012 num hospital de apoio perinatal diferenciado. Aplicou-se um inquérito na maternidade e posteriormente aos 3 e 6 meses. Avaliaram-se dados demográficos, antecedentes maternos, dados perinatais, expectativa da duração do AM e determinantes da interrupção. Análise estatística com SPSSv20®. Resultados: Dos 298 inquéritos, incluíram-se 292. Das mães com 31.4 anos ±5.8, 54.8%, eram primíparas. Gestação vigiada em 97.6%; 93.3% tinham peso adequado à idade gestacional e 5.2% eram de termo. O AM iniciou-se nas primeiras 2 horas em 96.9%. Na maternidade 29.0% fizeram ≥1 toma de fórmula para lactentes (FL) (principalmente por hipoglicemia), com correlação significativa com cesariana, peso inadequado à nascença e prematuridade. Na alta, 98.0% realizava AM. Mantinham AM 78.7% aos 3 meses e 53.1% aos 6 meses, sendo a hipogaláctea a principal causa de abandono. O uso de chupeta e FL não se associou a menor taxa de manutenção de AM. Discussão/ Conclusão: A prevalência de AM na maternidade foi elevada. RN com maior risco de hipoglicemia necessitaram mais frequentemente de FL. A hipogaláctea foi a principal causa de abandono. A compreensão dos condicionantes do AM deverá levar à melhoria das estratégias de promoção do início mas sobretudo da sua manutenção.

ResumoObjetivo:Avaliar a prevalência de deficiência de vitamina D e os fatores associados em mulheres e recém-nascidos no período pós-parto.Métodos:Estudo de delineamento transversal; avaliou-se a deficiência/insuficiência de vitamina D em 226 mulheres e seus recém-nascidos no município de Viçosa (MG), entre dezembro de 2011 e novembro de 2012. Coletaram-se 5mL de sangue do cordão umbilical e sangue venoso materno a fim de avaliar os parâmetros bioquímicos: vitamina D, fosfatase alcalina, cálcio, fósforo e paratormônio. Usou-se regressão de Poisson e adotou-se a Razão de Prevalência (95% IC), a fim de se avaliar a deficiência de vitamina D e fatores associados. Fez-se a análise de regressão linear múltipla para identificar os fatores associados à deficiência de 25(OH)D dos recém-nascidos e das mulheres do estudo. O critério para inclusão das variáveis na regressão linear múltipla foi a relação com a variável dependente na análise de regressão linear simples, considerando p

Copyright of Acta Scientiarum: Health Sciences is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Vancomycin is a glycopeptide antibiotic considered the gold standard in the treatment of staphylococcal infections that are oxacillin-resistant. Objective: To analyse the concentration of serum level in the voucher (one hour before the next administration of the drug dose) of vancomycin in newborns with Staphylococcus aureus infection or oxacillin-resistant coagulase-negative. Methods: This is an experimental study with data collection between the years 2001 and 2016. We selected 30 patients who had staphylococcus aureus and coagulase-negative sepsis and used vancomycin as a treatment. We collected and recorded their serum levels. Results: Of the 30 patients included in the present study, 80% were preterm. Among all the newborns, mean serum concentrations in the vancomycin valley were 40% adequate, 13.34% lower than expected, and 46.67% higher than the reference values. In seven patients (23.34%), the first serum level in the Vancomycin valley collected was adequate, but in nine (30%) and 14 (46.67%) patients, the serum concentration in the valley was respectively below and above the correct values. After dose shifting of those who did not achieve adequate levels, only three of the 14 patients in whom the first dose was not adequate had a mean serum total level within the expected range; the remaining 11 stayed at high levels, which raised great concern due to the fact that if the infection is not being treated, the elevated serum level leads to nephrotoxic and ototoxic problems. The monitoring of serum levels in the vancomycin valley is of great importance as it minimises nephrotoxic effects, thus increasing the efficacy of the drug. The dosage adjustment of vancomycin in severely ill patients admitted to an intensive care unit is important and requires more studies related to this area, as the work of a multidisciplinary body makes the treatment better and more specific. Conclusion: The concentrations of serum levels in the Vancomycin valley (10-15 µg/mL) in patients hospitalised in a neonatal intensive care unit of a reference hospital in Latin America were thought to be bactericidal; however, this is not the values observed in our study. [ABSTRACT FROM AUTHOR]

Copyright of Scire Salutis is the property of CBPC - Companhia Brasileira de Producao Cientifica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract A case is reported in which a 3-days old neonate with a giant ovarian cyst was scheduled for surgery. The patient received a dose of sugammadex to reverse a rocuronium-induced neuromuscular block. A fast and efficient recovery from neuromuscular block was achieved within 90 s. No adverse events or other safety concerns were observed. Furthermore, a review of the literature on the use of sugammadex in neonates was performed.

As interações mãe-bebê e suas repercussões na construção do psiquismo são abordadas pela Teoria do Apego, destacando-se a capacidade de mentalização materna como determinante na formação de um apego seguro. Este estudo objetivou compreender como uma intervenção psicoterápica, realizada com duplas mãe-bebê prematuro, durante a internação em UTIN, repercute na capacidade de mentalização materna, mediante pesquisa qualitativa de intervenção, exploratória e descritiva, de estudo de casos múltiplos, com avaliações antes e após a intervenção. Participaram duas díades mãe-bebê prematuro, internado em UTIN. Utilizaram-se como instrumentos antes da intervenção ficha de dados sociodemográficos e clínicos, entrevista de história de vida da mãe; e, após, entrevista de história da internação. Analisaram-se os dados por meio de dois eixos temáticos: a) Representações maternas sobre si mesma; b) Representações maternas sobre o bebê. Verificaram-se mudanças na capacidade de mentalização materna, o que favoreceu o vínculo mãe-bebê e a possível aplicação de intervenções voltadas às relações iniciais mãe-bebê prematuro em UTIN.

Objective:To analyze toll-like receptor (TLR)-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis.Methods:This prospective study included 27 full-term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late-onset sepsis. Ten newborns (37%) had positive cultures. Cytokines were measured by cytometric bead array in peripheral blood, while TLR-2, TLR-4 expression, and median fluorescence intensity (MFI) were determined by immunophenotyping peripheral whole blood monocytes, and were analyzed with a BD FACSDiva flow cytometer (Becton, Dickinson and Company, USA). A comparison was performed with healthy adults.Results:Microorganisms were identified in 37% of these septic newborns, and all of them had high levels of pro-inflammatory cytokines (IL-8, IL-6, IL-1β) and anti-inflammatory cytokine (IL-10) corroborating the inflammatory/septic process. In monocytes, the frequency of TLR-4 expression was higher in infected newborns (p = 0.01).Conclusion:This study investigated the innate immune response in septic newborns. Septic newborns that relied almost exclusively on the innate immune system showed little in vivo response at monocyte activation, suggesting impaired immune response and increased susceptibility to infection.

INTRODUÇÃO: A exposição fetal ao álcool pode causar consequências neonatais negativas, tais como transtornos do espectro alcoólico fetal (TEAF), caracterizada por uma tríade de manifestações clínicas relacionadas ao atraso no crescimento fetal-neonatal, dismorfismos faciais e alterações neurocomportamentais. Partindo da hipótese que essas manifestações clínicas podem estar associadas a biomarcadores genéticos neonatais, entende-se que estudos de polimorfismos genéticos possam ajudar a compreender as variações das manifestações clínicas em neonatos expostos ao álcool no período pré-natal. OBJETIVO: Avaliar as frequências alélicas e genotípicas do SNP -819C/T do gene da Interleucina-10 (IL-10) e sua associação com características clínicas dos TEAF em neonatos expostos ao álcool no período pré-natal. MÉTODO: Trata-se de um estudo transversal, descritivo, envolvendo neonatos expostos ao álcool no período pré-natal. É um recorte de uma pesquisa aprovada sob o Parecer CEP/UFAL n° 3.009.258/2018, realizada entre 2019 e 2021. Foram coletados dados clínicos, incluindo a aplicação do Índice de Finnegan e do Método de Dubowitz, e coleta de células bucais de neonatos para análise dos polimorfismos, cuja extração, quantificação e análise do DNA genômico foram realizadas a partir da PCR em tempo real com a finalidade de obter o perfil genômico da IL-10 destes neonatos. Para este estudo foram analisados os dados de 42 neonatos expostos ao álcool no período pré-natal, a partir do software Microsoft® Office Excel versão 2010, SNAPstates online, BioStat versão 2.0 e o GPower 3.0. A partir da análise de dados, os grupos foram divididos em "adequados" (aqueles que não apresentaram alteração clínica) e "alterados" (aqueles que apresentaram alguma manifestação clínica da tríade dos TEAF. Na análise estatística obteve-se o equilíbrio de Hardy-Weinberg igual a 1. RESULTADOS: Dentre os 42 neonatos estudados, 50% apresentaram o genótipo C/T, 38% o genótipo C/C e 12% o genótipo T/T, considerando os neonatos do grupo "alterado". Já a frequência alélica neste grupo correspondeu a 62% no alelo C e 32% para o alelo T. Além disso, os neonatos que compuseram esta amostra 26,19% apresentaram alterações neurocomportamentais e 9,52% peso abaixo do percentil 10. Em contrapartida, os neonatos expostos ao álcool e que não apresentaram nenhum tipo de alteração, percebeu-se que 50% apresentou o genótipo C/C, 42% o genótipo T/Ce 8% o genótipo T/T. Em relação aos alelos neste grupo, 71% dos neonatos apresentaram o alelo C e 29% o alelo T. Comparando grupo de neonatos expostos ao álcool ao grupo de neonatos expostos ao álcool associado a outras drogas, observou-se a Razão de Prevalência = 3,56 vezes, ou seja, os neonatos expostos ao álcool associado a outras drogas têm 256% de chances de manifestar manifestações clínicas da tríade dos TEAF. Não se observou associação das manifestações clínicas da tríade dos TEAF ao polimorfismo - 819C/T, da IL-10, necessitando ampliar o número amostral. CONCLUSÃO: Os neonatos expostos ao álcool in útero possuem prevalência do genótipo C/T. Há maior chance de manifestar alterações neurocomportamentais e peso inadequado para a idade gestacional se exposto ao álcool associado a outras drogas. Já os neonatos expostos ao álcool in útero, que não apresentaram nenhuma alteração clínica, possuíram o perfil genotípico para a IL-10 com o gene C/C. Em ambos os grupos estudados, houve prevalência do alelo C. [ABSTRACT FROM AUTHOR]

Introdução: O uso de drogas lícitas e ilícitas na gravidez pode ocasionar malefícios à mãe, ao feto ou neonato, que precisam ser melhor compreendidos. Estudos demonstram que a exposição in utero às drogas tem sido associada aos marcadores de ativação inflamatória em neonatos, como a Interleucina 10 (IL-10). As citocinas podem ser marcadores potenciais para esclarecer as alterações comportamentais de neonatos expostos ao tabaco e outras drogas. Objetivo: Identificar a frequência genotípica do SNP -819T/C do gene da IL-10 em neonatos expostos ao tabaco e outras drogas no período pré-natal e sua associação com as alterações neurocomportamentais dos neonatos. Metodologia: Trata-se de um estudo transversal, descritivo, realizado a partir de um banco de dados de uma pesquisa aprovada sob o Parecer CEP/UFAL n° 3.009.258/2018, desenvolvida entre 2019 e 2021 com neonatos expostos a drogas no período pré-natal. A amostra incluiu o total de 29 neonatos, que foram divididos em dois grupos - Grupo 1 (sem alterações neurocomportamentais) e Grupo 2 (com alterações neurocomportamentais). Para a identificação do perfil genotípico do polimorfismo - 819T/C da IL-10, foram analisados os resultados das etapas de extração, quantificação e análise do DNA genômico a partir da PCR em tempo real. Para identificação das alterações neurocomportamentais, foi analisado o banco de dados clínicos dos neonatos que foram avaliados utilizando o Índice de Finnegan e o Método de Dubowitz. Para análise dos dados foram utilizados o software Microsoft® Office Excel versão 2010, SNPstats online e o GPower 3.0. A população estudada apresentou equilíbrio de Hardy-Weinberg. Resultados: Observou-se que 50% dos neonatos do Grupo 1, assim como 50% do Grupo 2, apresentaram o genótipo heterozigoto C/T para o polimorfismo -819T/C (IL-10). O genótipo homozigoto C/C foi o segundo mais frequente, sendo encontrado em 50% neonatos do Grupo 1 e 40% do Grupo 2, seguido do genótipo homozigoto T/T presente em 10% neonato do Grupo 2, porém não encontrado no grupo 1. Não foi possível observar associação na população estudada, uma vez que p>0,05; entretanto o poder amostral foi <0,08; necessitando ampliar o número amostral, uma vez que a literatura corrobora com uma possível associação. Conclusão: O genótipo heterozigoto C/T foi o mais encontrado em neonatos com e sem alterações neurocomportamentais, enquanto o genótipo T/T foi o menos frequente, sendo encontrado apenas no grupo com alterações neurocomportamentais. Não foi possível observar associação com a presença das alterações neurocomportamentais, necessitando ampliar o número amostral. [ABSTRACT FROM AUTHOR]

This is a descriptive and cross-sectional epidemiological study aimed at discussing the circumstances of newborns deaths in the Maternal Neonatal Intensive Care Unit of the Hospital Nossa Senhora Auxiliadora in the years 2014 to 2016, relating then to the conditions of the newborn, the mother and the childbirth. The data were obtained based on the analysis of medical records. Of the total of 29 deaths, 18 (62,07%) presented an initial diagnosis related to respiratory diseases. The sample consists predominantly of female, premature and very low birth weight individuals, it is evident that mortality was significantly associated with these variables. It was concluded that the improvement in the health care network for women and children would reduce the number of premature and low birth weight newborns, which would positively reflect neonatal and postnatal mortality rates. [ABSTRACT FROM AUTHOR]

The research traces an epidemiologic profile of newborns with congenital malformation living in the state of Pernambuco in 2014. It is known that congenital malformation consists in alterations during the cell-splitting process or genetic disturbance and the social-economic and sociocultural factors, which interfere in this process as well. It is an epidemiologic study, transversal, quantitative and descriptive. It was used secondary data extracted from the SINASC (Information system about the living newborn). The dependent variable was the presence of congenital malformation when they are born, while the independent variable data is connected to the mother and the newborn. From the 142.263 newborn children alive, 1.226 were notified with congenital malformation. In this group, most of them are boys, with average body weight and normal pregnancy time and predominance malformation of the musculoskeletal system. The mothers were young, single, with good education and most of them were submitted to caesarean section. The hospital was the main childbirth place. While observed, there is a need to perform a deeper research about this subject, as well as review the given assistance to these mothers in a qualitative point of view. It is concluded that the preventive measures are really important and urgent. There is a need to have a more direct contact with the mothers in order to raise awareness in them about the risks that are being exposed to them and the developing fetus. [ABSTRACT FROM AUTHOR]

Objective: To study the prevalence of congenital anomalies in newborns in the city of São Paulo from 2010 to 2014, as well as to analyze other variables associated with the anomalies. Methods: Data was collected from the Ministry of Health's Live Births Information System (SINASC) from 2010 to 2014 in São Paulo City. The variables analyzed were length and type of pregnancy, maternal age, and ethnicity and sex of the newborn. The absolute and relative frequencies of congenital anomalies were verified, and the variables associated with them were calculated with the odds ratio (OR) and a 95% confidence interval. Results: A total of 819,018 live births occurred in the city of São Paulo, and in 14,657 (1.6%) of them, some congenital anomaly was reported. The most frequent congenital anomalies found were those related to osteoarticular system followed by those related to the cardiovascular system. Risks associated with the presence of congenital anomalies were observed in the following factors: maternal age over 40 years (OR=1.59; 95%CI 1.47-1.71), multiple pregnancies (OR=1.28; 95%CI 1.19-3.77), and low birth weight (OR=3.35; 95%CI 3.21-3.49). The female gender was considered a protective variable (OR=0.78; 95%CI 0.75-0.81). Conclusions: Congenital anomalies are responsible for morbidity and mortality in the neonatal period. Their early diagnosis is important for planning and resource allocation of specialized health services directed toward the families and infants. [ABSTRACT FROM AUTHOR]