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2. Near-death experiences after cardiac arrest: a scoping review

Author

Kovoor, Joshua G., Santhosh, Sanjana, Stretton, Brandon, Tan, Sheryn, Gouldooz, Hasti, Moorthy, Sylviya, Pietris, James, Hannemann, Christopher, Yu, Long Kiu, Johnson, Rhys, Reddi, Benjamin A., Gupta, Aashray K., Wagner, Morganne, Page, Gregory J., Kovoor, Pramesh, Bastiampillai, Tarun, Maddocks, Ian, Perry, Seth W., Wong, Ma-Li, Licinio, Julio, and Bacchi, Stephen

Published
2024
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3. Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months

Author

Hodgson, Carol, Fulcher, Bentley, Linke, Natalie, Board, Jasmin, Buhr, Heidi, Cooper, Jamie, Fraser, John, Bernard, Stephen, Brodie, Daniel, Pilcher, David, Fan, Eddy, Udy, Andrew, Gattas, David, Pellegrino, Vincent, Hopper, Ingrid, Litton, Ed, Nair, Priya, Orford, Neil, Parke, Rachael, Stub, Dion, Higgins, Alisa M., Burrell, Aidan, McGuiness, Shay, Reddi, Benjamin, Trapani, Tony, Huckson, Sue, Anderson, Shannah, Dicker, Craig, Jones, Annalie, Martin, Emma, McCracken, Phoebe, Sheldrake, Jayne, Vallance, Shirley, Young, Meredith, Bellomo, Rinaldo, Eastwood, Glenn, Hilton, Andrew, Peck, Leah, Dyett, John, Hunter, Stephanie, Liew, Cheelim, Heard, Joshua, Lijo, Sebastian, Nourse, Mary, Rai, Sumeet, Singh, Manoj, Veerendra, Hemanth, Xu, Tina, Barrett, Jonathan, Brooks, Kyle, Hanlon, Gabrielle, Allen, Chris, Bizzell, Samantha, Eroglu, Ege, Palermo, Annamaria, Pellicano, Susan, Bersten, Andrew, Bihari, Shailesh, Brown, Julia, Comerford, Sharon, Grear, Laura, McIntyre, Joanne, Jin, Xia, Wiersema, Ubbo, Figures, Dee, Gough, Maimoonbe, Pitman, Julie, Tallott, Mandy, Winearls, James, Brieva, Jorge, Hopkins, Madeleine, Jayarman, Nanda, Poulter, Amber-Louise, Quarello, Kate, Aneman, Anders, Austin, Danielle, McCanny, Peter, Miller, Jennene, Murfin, Brendan, Cox, Yolanda, Guo, Stephanie, Shehabi, Yayha, Brown, Amanda, Butt, Pamela, Bushell, Rachel, Lavana, Jayshree, Lockwood, Dawn, Pearce, India, Salt, Gavin, Thambiraj, Solomon, Howard, Meg, Joyce, Chris, Meyer, Jason, Walsham, James, Brown, Nerissa, Glasby, Kathleen, O'Connor, Stephanie, Rivett, Justine, Yap, Joannies, Bristow, Debra, Pincus, Jason, Stuart, Janine, Anstey, James, Barge, Deborah, Butler, Menoly, Gebbie, Bradley, Bass, Frances, Janin, Pierre, Hammond, Naomi, Potger, Kieron, Yarad, Elizabeth, Carey, Ruaidhri, Coles, Jennifer, Totaro, Richard, Anstey, Matthew, Endemann, Anthadene, Hardy, Sarah, Popa, Roxana, Richards, Stephen, Rock, Lara, Wibrow, Bradley, Barbazza, Leanne, Dixon, Barry, Holmes, Jennifer, Hurune, Patricia, O'Brien, Yvette, Buscher, Hergen, Newman, Sally, Reynolds, Claire, Henson, Gail, Senthuran, Siva, Win, April, Breguet, Samantha, Horton, Michelle, McCaffrey, Joe, Trickey, Jemma, Bannerjee, Ashoke, Davidson, Benjamin, Joy, Jenyfer, Kong, Jing, Ertugrul, Atacan D., Neto, Ary Serpa, Fulcher, Bentley J., Charles-Nelson, Anaïs, Bailey, Michael, Burrell, Aidan J.C., Board, Jasmin V., Cooper, D. James, Fraser, John F., Gattas, David J., Hopper, Ingrid K., Linke, Natalie J., Litton, Edward, McGuinness, Shay P., Parke, Rachael L., Pellegrino, Vincent A., Pilcher, David V., Udy, Andrew A., Reddi, Benjamin A.J., Trapani, Tony V., and Hodgson, Carol L.

Published
2024
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4. Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Author

Ryan, Feargal J, Hope, Christopher M, Masavuli, Makutiro G, Lynn, Miriam A, Mekonnen, Zelalem A, Yeow, Arthur Eng Lip, Garcia-Valtanen, Pablo, Al-Delfi, Zahraa, Gummow, Jason, Ferguson, Catherine, O’Connor, Stephanie, Reddi, Benjamin AJ, Hissaria, Pravin, Shaw, David, Kok-Lim, Chuan, Gleadle, Jonathan M, Beard, Michael R, Barry, Simon C, Grubor-Bauk, Branka, and Lynn, David J

Subjects
Emerging Infectious Diseases, Vaccine Related, Pneumonia & Influenza, Lung, Pneumonia, Prevention, Infectious Diseases, Genetics, Biodefense, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Antibodies, Viral, COVID-19, Humans, Immune System, SARS-CoV-2, Post-Acute COVID-19 Syndrome, Immunity, RNA-Seq, T cell, Antibody responses, Convalescent patients, Immunophenotyping, Long COVID, Post-acute sequelae of COVID-19, Post COVID-19 condition, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms for many months after infection, a condition referred to as "long COVID", post-acute sequelae of COVID-19 (PASC), post-acute COVID-19 syndrome, or post COVID-19 condition. However, despite the plethora of research on COVID-19, relatively little is known about the molecular underpinnings of these long-term effects.MethodsWe have undertaken an integrated analysis of immune responses in blood at a transcriptional, cellular, and serological level at 12, 16, and 24 weeks post-infection (wpi) in 69 patients recovering from mild, moderate, severe, or critical COVID-19 in comparison to healthy uninfected controls. Twenty-one of these patients were referred to a long COVID clinic and > 50% reported ongoing symptoms more than 6 months post-infection.ResultsAnti-Spike and anti-RBD IgG responses were largely stable up to 24 wpi and correlated with disease severity. Deep immunophenotyping revealed significant differences in multiple innate (NK cells, LD neutrophils, CXCR3+ monocytes) and adaptive immune populations (T helper, T follicular helper, and regulatory T cells) in convalescent individuals compared to healthy controls, which were most strongly evident at 12 and 16 wpi. RNA sequencing revealed significant perturbations to gene expression in COVID-19 convalescents until at least 6 months post-infection. We also uncovered significant differences in the transcriptome at 24 wpi of convalescents who were referred to a long COVID clinic compared to those who were not.ConclusionsVariation in the rate of recovery from infection at a cellular and transcriptional level may explain the persistence of symptoms associated with long COVID in some individuals.

Published
2022

5. Sociocultural and Demographic Factors Predict Readmissions for General Surgery Patients

Author

Kovoor, Joshua G., Bacchi, Stephen, Gupta, Aashray K., Nann, Silas D., Stretton, Brandon, Chong, Esther H. L., Hewitt, Joseph N., Bhanushali, Ameya, Nathin, Kayla, Aujayeb, Nidhi, Lu, Amy, Ovenden, Christopher D., John, Athul, Reid, Jessica L., Gluck, Samuel, Liew, Danny, Reddi, Benjamin A., Hugh, Thomas J., Dobbins, Christopher, Padbury, Robert T., Hewett, Peter J., Trochsler, Markus I., and Maddern, Guy J.

Published
2023
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6. Comparison of baseline characteristics, treatment and clinical outcomes of critically ill COVID-19 patients admitted in the first and second waves in Australia

Author

Burrell, Aidan JC, Neto, Ary Serpa, Broadley, Tessa, Trapani, Tony, Begum, Husna, Campbell, Lewis T, Cheng, Allen C, Cheung, Winston, Cooper, D James, Erickson, Simon J, French, Craig J, Kaldor, John M, Litton, Edward, Murthy, Srinivas, McAllister, Richard E, Nichol, Alistair D, Palermo, Annamaria, Plummer, Mark P, Ramanan, Mahesh, Reddi, Benjamin AJ, Reynolds, Claire, Webb, Steve A, and Udy, Andrew A

Published
2021

7. SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents

Author

Garcia-Valtanen, Pablo, Hope, Christopher M, Masavuli, Makutiro G, Yeow, Arthur Eng Lip, Balachandran, Harikrishnan, Mekonnen, Zelalem A, Al-Delfi, Zahraa, Abayasingam, Arunasingam, Agapiou, David, Stella, Alberto Ospina, Aggarwal, Anupriya, Bouras, George, Gummow, Jason, Ferguson, Catherine, O’Connor, Stephanie, McCartney, Erin M, Lynn, David J, Maddern, Guy, Gowans, Eric J, Reddi, Benjamin AJ, Shaw, David, Kok-Lim, Chuan, Beard, Michael R, Weiskopf, Daniela, Sette, Alessandro, Turville, Stuart G, Bull, Rowena A, Barry, Simon C, and Grubor-Bauk, Branka

Subjects
Infectious Diseases, Pneumonia & Influenza, Pneumonia, Prevention, Biodefense, Lung, Immunization, Vaccine Related, Emerging Infectious Diseases, Infection, Good Health and Well Being, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Humans, Reinfection, SARS-CoV-2, Spike Glycoprotein, Coronavirus, T-Lymphocytes, T cell immunity, Variant of Concern, antibody response, antigen drift, memory B cells, virus neutralization
Abstract

Coronavirus disease 2019 (COVID-19) convalescents living in regions with low vaccination rates rely on post-infection immunity for protection against re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluate humoral and T cell immunity against five variants of concern (VOCs) in mild-COVID-19 convalescents at 12 months after infection with ancestral virus. In this cohort, ancestral, receptor-binding domain (RBD)-specific antibody and circulating memory B cell levels are conserved in most individuals, and yet serum neutralization against live B.1.1.529 (Omicron) is completely abrogated and significantly reduced for other VOCs. Likewise, ancestral SARS-CoV-2-specific memory T cell frequencies are maintained in >50% of convalescents, but the cytokine response in these cells to mutated spike epitopes corresponding to B.1.1.529 and B.1.351 (Beta) VOCs were impaired. These results indicate that increased antigen variability in VOCs impairs humoral and spike-specific T cell immunity post-infection, strongly suggesting that COVID-19 convalescents are vulnerable and at risk of re-infection with VOCs, thus stressing the importance of vaccination programs.

Published
2022

9. Delayed return of bowel function after general surgery in South Australia

Author

Kovoor, Joshua G., Bacchi, Stephen, Stretton, Brandon, Gupta, Aashray K., Jacobsen, Jonathan Henry W., To, Minh-Son, Goh, Rudy, Hewitt, Joseph N., Ovenden, Christopher D., Warren, Leigh, Marshall-Webb, Matthew, Jones, Karen L., Reddi, Benjamin A., Liew, Danny, Dobbins, Christopher, Padbury, Robert T., Hewett, Peter J., Hugh, Thomas J., Trochsler, Markus I., and Maddern, Guy J.

Published
2024
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10. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author

Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S. R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P. S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P. J.

Published
2023
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11. Diabetes mellitus, glycaemic control, and severe COVID-19 in the Australian critical care setting: A nested cohort study

Author

Visser, Adam, Mattke, Adrian, Regli, Adrian, Rashid, Alan, Tabah, Alexis, Walker, Alison, Cheng, Allen, Corley, Amanda, Udy, Andrew, Ramnani, Anil, Eidan, Anthony, DeKeulenaer, Bart, Reddi, Benjamin, Richards, Brent, Knott, Cameron, Moore, Cara, Delzoppo, Carmel, Boschert, Catherine, Tacon, Catherine, French, Craig, Austin, Danielle, Brewster, David, Cooper, David, Crosbie, David, Hawkins, David, Jessen, Edda, Martinez, Eduardo, Fysh, Edward, Litton, Edward, Oberender, Felix, McGain, Forbes, Salt, Gavin, Eastwood, Glenn, Taori, Gopal, White, Hayden, Buscher, Hergen, Seppelt, Ian, Leditschke, Isabel Anne, Young, Janelle, Lavana, Jayshree, Cohen, Jeremy, Lugsdin, Jessica, Botha, John, Santamaria, John, Barrett, Jonathan, Singh, Kasha, Laupland, Kevin, El-Khawas, Khaled, Estensen, Kristine, Deshpande, Kush, White, Kyle, Fitzpatrick, Leigh, Campbell, Lewis, Ramanan, Mahesh, Saxena, Manoj, Kainer, Marion, Kol, Mark, Page, Mark, Plummer, Mark, Sterba, Martin, Anstey, Matthew, Brain, Matthew, Maiden, Matthew, Kilminster, Myrene, Hammond, Naomi, Bhadange, Neeraj, Humphreys, Nicole, Jain, Paras, Azzi, Paul, Secombe, Paul, Lister, Paula, Chan, Peter, McCanny, Peter, Britton, Phillip, Janin, Pierre, Krishnamurthy, Ravi, Sonawane, Ravikiran, Tiruvoipati, Ravindranath, Totaro, Richard, Bellomo, Rinaldo, Sanghavi, Ritesh, Bates, Samantha, Peake, Sandra, Bihari, Shailesh, George, Shane, Erickson, Simon, Webb, Steve, Arora, Subhash, Ganu, Subodh, Rozen, Thomas, McKenna, Toni, Kadam, Umesh, Nayyar, Vineet, Choy, Wei Han, Albassam, Wisam, Plummer, Mark P., Rait, Louise, Finnis, Mark E., French, Craig J., Douglas, James, Bhurani, Mansi, Broadley, Tessa, Trapani, Tony, Deane, Adam M., Udy, Andrew A., and Burrell, Aidan J.C.

Published
2023
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12. Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months

Author

Ertugrul, Atacan D., Neto, Ary Serpa, Fulcher, Bentley J., Charles-Nelson, Anaïs, Bailey, Michael, Burrell, Aidan J.C., Anderson, Shannah, Bernard, Stephen, Board, Jasmin V., Brodie, Daniel, Buhr, Heidi, Cooper, D. James, Dicker, Craig, Fan, Eddy, Fraser, John F., Gattas, David J., Hopper, Ingrid K., Huckson, Sue, Linke, Natalie J., Litton, Edward, McGuinness, Shay P., Nair, Priya, Orford, Neil, Parke, Rachael L., Pellegrino, Vincent A., Pilcher, David V., Stub, Dion, Udy, Andrew A., Reddi, Benjamin A.J., Trapani, Tony V., Jones, Annalie, Higgins, Alisa M., Hodgson, Carol L., Hodgson, Carol, Fulcher, Bentley, Linke, Natalie, Board, Jasmin, Buhr, Heidi, Cooper, Jamie, Fraser, John, Bernard, Stephen, Brodie, Daniel, Pilcher, David, Fan, Eddy, Udy, Andrew, Gattas, David, Pellegrino, Vincent, Hopper, Ingrid, Litton, Ed, Nair, Priya, Orford, Neil, Parke, Rachael, Stub, Dion, Higgins, Alisa M., Burrell, Aidan, McGuiness, Shay, Reddi, Benjamin, Trapani, Tony, Huckson, Sue, Anderson, Shannah, Dicker, Craig, Jones, Annalie, Board, Jasmin, Jones, Annalie, Martin, Emma, McCracken, Phoebe, Pellegrino, Vincent, Sheldrake, Jayne, Vallance, Shirley, Young, Meredith, Bellomo, Rinaldo, Eastwood, Glenn, Hilton, Andrew, Peck, Leah, Dyett, John, Hunter, Stephanie, Liew, Cheelim, Heard, Joshua, Lijo, Sebastian, Nourse, Mary, Rai, Sumeet, Singh, Manoj, Veerendra, Hemanth, Xu, Tina, Barrett, Jonathan, Brooks, Kyle, Hanlon, Gabrielle, Allen, Chris, Bizzell, Samantha, Eroglu, Ege, Litton, Ed, Palermo, Annamaria, Pellicano, Susan, Bersten, Andrew, Bihari, Shailesh, Brown, Julia, Comerford, Sharon, Grear, Laura, McIntyre, Joanne, Jin, Xia, Wiersema, Ubbo, Figures, Dee, Gough, Maimoonbe, Pitman, Julie, Tallott, Mandy, Winearls, James, Brieva, Jorge, Hopkins, Madeleine, Jayarman, Nanda, Poulter, Amber-Louise, Quarello, Kate, Aneman, Anders, Austin, Danielle, McCanny, Peter, Miller, Jennene, Murfin, Brendan, Cox, Yolanda, Guo, Stephanie, Shehabi, Yayha, Brown, Amanda, Butt, Pamela, Bushell, Rachel, Fraser, John, Lavana, Jayshree, Lockwood, Dawn, Pearce, India, Salt, Gavin, Thambiraj, Solomon, Howard, Meg, Joyce, Chris, Meyer, Jason, Walsham, James, Brown, Nerissa, Glasby, Kathleen, O'Connor, Stephanie, Reddi, Benjamin, Rivett, Justine, Yap, Joannies, Bristow, Debra, Pincus, Jason, Stuart, Janine, Anstey, James, Barge, Deborah, Butler, Menoly, Gebbie, Bradley, Bass, Frances, Janin, Pierre, Hammond, Naomi, Potger, Kieron, Yarad, Elizabeth, Buhr, Heidi, Carey, Ruaidhri, Coles, Jennifer, Gattas, David, Totaro, Richard, Anstey, Matthew, Endemann, Anthadene, Hardy, Sarah, Popa, Roxana, Richards, Stephen, Rock, Lara, Wibrow, Bradley, Barbazza, Leanne, Dixon, Barry, Holmes, Jennifer, Hurune, Patricia, O'Brien, Yvette, Buscher, Hergen, Nair, Priya, Newman, Sally, Reynolds, Claire, Henson, Gail, Senthuran, Siva, Win, April, Breguet, Samantha, Horton, Michelle, McCaffrey, Joe, Orford, Neil, Trickey, Jemma, Bannerjee, Ashoke, Davidson, Benjamin, Joy, Jenyfer, and Kong, Jing

Abstract

Extracorporeal membrane oxygenation (ECMO) is a high-risk procedure with significant morbidity and mortality and there is an uncertain volume-outcome relationship, especially regarding long-term functional outcomes. The aim of this study was to examine the association between ECMO centre volume and long-term death and disability outcomes.

Published
2024
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13. Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study

Author

Hodgson, Carol L, Higgins, Alisa M, Bailey, Michael J, Anderson, Shannah, Bernard, Stephen, Fulcher, Bentley J, Koe, Denise, Linke, Natalie J, Board, Jasmin V, Brodie, Daniel, Buhr, Heidi, Burrell, Aidan J C, Cooper, D James, Fan, Eddy, Fraser, John F, Gattas, David J, Hopper, Ingrid K, Huckson, Sue, Litton, Edward, McGuinness, Shay, Nair, Priya, Orford, Neil, Parke, Rachael L, Pellegrino, Vincent A, Pilcher, David V, Sheldrake, Jayne Sheldrake, Reddi, Benjamin A J, Stub, Dion, Trapani, Tony V, Udy, Andrew A, Serpa Neto, Ary, McGuinness, Shay P, and Sheldrake, Jayne

Published
2022
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15. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices

Author

van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.

Published
2023
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17. Effects of brain tissue oxygen (PbtO2) guided management on patient outcomes following severe traumatic brain injury: A systematic review and meta-analysis

Author

Hays, Leanne M.C., Udy, Andrew, Adamides, Alexios A, Anstey, James R., Bailey, Michael, Bellapart, Judith, Byrne, Kathleen, Cheng, Andrew, Jamie Cooper, D., Drummond, Katharine J., Haenggi, Matthias, Jakob, Stephan M., Higgins, Alisa M., Lewis, Philip M., Hunn, Martin K., McNamara, Robert, Menon, David K., Murray, Lynne, Reddi, Benjamin, Trapani, Tony, Vallance, Shirley, Young, Paul J., Diaz-Arrastia, Ramon, Shutter, Lori, Murray, Patrick T., Curley, Gerard F., and Nichol, Alistair

Published
2022
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18. Optimising a targeted test reduction intervention for patients admitted to the intensive care unit: The Targeted Intensive Care Test Ordering Cluster Trial intervention

Author

Litton, Edward, Atkinson, Helen, Anstey, James, Anstey, Matthew, Campbell, Lewis T., Forbes, Andrew, Hahn, Rebecca, Hooper, Katherine, Kasza, Jessica, Knapp, Sharon, McGain, Forbes, Ngyuen, Nhi, Pilcher, David, Reddi, Benjamin, Reid, Chris, Robinson, Suzanne, Thompson, Kelly, Webb, Steve, and Young, Paul

Published
2021
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20. A survey of extracorporeal membrane oxygenation practice in 23 Australian adult intensive care units

Author

Linke, Natalie J, Fulcher, Bentley J, Engeler, Daniel M, Anderson, Shannah, Bailey, Michael J, Bernard, Stephen, Board, Jasmin V, Brodie, Daniel, Buhr, Heidi, Burrell, Aidan JC, Cooper, David J, Fan, Eddy, Fraser, John F, Gattas, David J, Higgins, Alisa M, Hopper, Ingrid K, Huckson, Sue, Litton, Edward, McGuinness, Shay P, Nair, Priya, Orford, Neil, Parke, Rachael L, Pellegrino, Vincent A, Pilcher, David V, Sheldrake, Jayne, Reddi, Benjamin AJ, Stub, Dion, Trapani, Tony V, Udy, Andrew A, and Hodgson, Carol L

Published
2020

23. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Author

Raasveld, Senta Jorinde, primary, Karami, Mina, additional, Schenk, Jimmy, additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, van den Bergh, Walter M., additional, Oude Lansink‐Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, Taccone, Fabio Silvio, additional, Peluso, Lorenzo, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Scholten, Erik, additional, Overmars, Martijn, additional, Ivančan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, Hermans, Greet, additional, Broman, Lars Mikael, additional, Henriques, José P. S., additional, and Vlaar, Alexander P. J., additional

Published
2023
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25. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation:A multicenter retrospective observational cohort study

Author

Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., and Vlaar, Alexander P.J.

Abstract

Background: Evidence-based recommendations for transfusion in patients with venoarterial extracorporeal membrane oxygenation (VA ECMO) are scarce. The current literature is limited to single-center studies with small sample sizes, therefore complicating generalizability. This study aims to create an overview of red blood cell (RBC) transfusion in VA ECMO patients. Methods: This international mixed-method study combined a survey with a retrospective observational study in 16 centers. The survey inventoried local transfusion guidelines. Additionally, retrospective data of all adult patients with a VA ECMO run >24 h (January 2018 until July 2019) was collected of patient, ECMO, outcome, and daily transfusion parameters. All patients that received VA ECMO for primary cardiac support were included, including surgical (i.e., post-cardiotomy) and non-surgical (i.e., myocardial infarction) indications. The primary outcome was the number of RBC transfusions per day and in total. Univariable logistic regressions and a generalized linear mixed model (GLMM) were performed to assess factors associated with RBC transfusion. Results: Out of 419 patients, 374 (89%) received one or more RBC transfusions. During a median ECMO run of 5 days (1st–3rd quartile 3–8), patients received a median total of eight RBC units (1st–3rd quartile 3–17). A lower hemoglobin (Hb) prior to ECMO, longer ECMO-run duration, and hemorrhage were associated with RBC transfusion. After correcting for duration and hemorrhage using a GLMM, a different transfusion trend was found among the regimens. No unadjusted differences were found in overall survival between either transfusion status or the different regimens, which remained after adjustment for potential confounders. Conclusion: RBC transfusion in patients on VA ECMO is very common. The sum of RBC transfusions increases rapidly after ECMO initiation, and is dependent on the

Published
2023

26. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation:A Secondary Analysis of an International Observational Study on Current Practices

Author

Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., Müller, Marcella C.A., Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.

Abstract

OBJECTIVES: To achieve optimal hemostatic balance in patients on extracorporeal membrane oxygenation (ECMO), a liberal transfusion practice is currently applied despite clear evidence. We aimed to give an overview of the current use of plasma, fibrinogen concentrate, tranexamic acid (TXA), and prothrombin complex concentrate (PCC) in patients on ECMO.DESIGN: A prespecified subanalysis of a multicenter retrospective study. Venovenous (VV)-ECMO and venoarterial (VA)-ECMO are analyzed as separate populations, comparing patients with and without bleeding and with and without thrombotic complications. SETTING: Sixteen international ICUs.PATIENTS: Adult patients on VA-ECMO or VV-ECMO.INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 420 VA-ECMO patients, 59% (n = 247) received plasma, 20% (n = 82) received fibrinogen concentrate, 17% (n = 70) received TXA, and 7% of patients (n = 28) received PCC. Fifty percent of patients (n = 208) suffered bleeding complications and 27% (n = 112) suffered thrombotic complications. More patients with bleeding complications than patients without bleeding complications received plasma (77% vs. 41%, p < 0.001), fibrinogen concentrate (28% vs 11%, p < 0.001), and TXA (23% vs 10%, p < 0.001). More patients with than without thrombotic complications received TXA (24% vs 14%, p = 0.02, odds ratio 1.75) in VA-ECMO, where no difference was seen in VV-ECMO. Of 205 VV-ECMO patients, 40% (n = 81) received plasma, 6% (n = 12) fibrinogen concentrate, 7% (n = 14) TXA, and 5% (n = 10) PCC. Thirty-nine percent (n = 80) of VV-ECMO patients suffered bleeding complications and 23% (n = 48) of patients suffered thrombotic complications. More patients with than without bleeding complications received plasma (58% vs 28%, p < 0.001), fibrinogen concentrate (13% vs 2%, p < 0.01), and TXA (11% vs 2%, p < 0.01).

Published
2023

27. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation:a multicenter observational study

Author

Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P.J.

Abstract

Background: Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-center experiences with high degrees of heterogeneity. Therefore, we aimed to ascertain in a multicenter study the course and occurrence rate of thrombocytopenia, and to assess the association between thrombocytopenia, hemorrhage and platelet transfusion during VA ECMO. Methods: This was a sub-study of a multicenter (N = 16) study on transfusion practices in patients on VA ECMO, in which a retrospective cohort (Jan-2018–Jul-2019) focusing on platelets was selected. The primary outcome was thrombocytopenia during VA ECMO, defined as mild (100–150·109/L), moderate (50–100·109/L) and severe (< 50·109/L). Secondary outcomes included the occurrence rate of platelet transfusion, and the association between thrombocytopenia, hemorrhage and platelet transfusion, assessed through mixed-effect models.Results: Of the 419 patients included, median platelet count at admission was 179·109/L. During VA ECMO, almost all (N = 398, 95%) patients developed a thrombocytopenia, of which a significant part severe (N = 179, 45%). One or more platelet transfusions were administered in 226 patients (54%), whereas 207 patients (49%) suffered a hemorrhagic event during VA ECMO. In non-bleeding patients, still one in three patients received a platelet transfusion. The strongest association to receive a platelet transfusion was found in the presence of severe thrombocytopenia (adjusted OR 31.8, 95% CI 17.9–56.5). After including an interaction term of hemorrhage and thrombocytopenia, this even increased up to an OR of 110 (95% CI 34–360). Conclusions: Thrombocytopenia has a higher occurrence than is currently recognized. Severe thrombocytopenia is strongl

Published
2023

28. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., Müller, Marcella C.A., Medische Staf Intensive Care, Other research (not in main researchprogram), Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.

Published
2023

29. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., and Vlaar, Alexander P.J.

Published
2023

30. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P.J.

Published
2023

31. Impact of perioperative direct oral anticoagulant assays: a multicenter cohort study

Author

Stretton, Brandon, primary, Kovoor, Joshua, additional, Bacchi, Stephen, additional, Booth, Andrew, additional, Gluck, Sam, additional, Vanlint, Andrew, additional, Afzal, Mohammed, additional, Ovenden, Christopher, additional, Gupta, Aashray, additional, Mahajan, Rajiv, additional, Edwards, Suzanne, additional, Brennan, Yvonne, additional, Boey, Jir Ping, additional, Reddi, Benjamin, additional, Maddern, Guy, additional, and Boyd, Mark, additional

Published
2023
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34. The Adelaide Score: An artificial intelligence measure of readiness for discharge after general surgery.

Author

Kovoor, Joshua G., Bacchi, Stephen, Gupta, Aashray K., Stretton, Brandon, Malycha, James, Reddi, Benjamin A., Liew, Danny, O'Callaghan, Patrick G., Beltrame, John F., Zannettino, Andrew C., Jones, Karen L., Horowitz, Michael, Dobbins, Christopher, Hewett, Peter J., Trochsler, Markus I., and Maddern, Guy J.

Subjects
SURGERY, ARTIFICIAL intelligence, MACHINE learning, MEDICAL personnel, RANDOM forest algorithms
Abstract

Background: This study aimed to examine the performance of machine learning algorithms for the prediction of discharge within 12 and 24 h to produce a measure of readiness for discharge after general surgery. Methods: Consecutive general surgery patients at two tertiary hospitals, over a 2‐year period, were included. Observation and laboratory parameter data were stratified into training, testing and validation datasets. Random forest, XGBoost and logistic regression models were evaluated. Each ward round note time was taken as a different event. Primary outcome was classification accuracy of the algorithmic model able to predict discharge within the next 12 h on the validation data set. Results: 42 572 ward round note timings were included from 8826 general surgery patients. Discharge occurred within 12 h for 8800 times (20.7%), and within 24 h for 9885 (23.2%). For predicting discharge within 12 h, model classification accuracies for derivation and validation data sets were: 0.84 and 0.85 random forest, 0.84 and 0.83 XGBoost, 0.80 and 0.81 logistic regression. For predicting discharge within 24 h, model classification accuracies for derivation and validation data sets were: 0.83 and 0.84 random forest, 0.82 and 0.81 XGBoost, 0.78 and 0.79 logistic regression. Algorithms generated a continuous number between 0 and 1 (or 0 and 100), representing readiness for discharge after general surgery. Conclusions: A derived artificial intelligence measure (the Adelaide Score) successfully predicts discharge within the next 12 and 24 h in general surgery patients. This may be useful for both treating teams and allied health staff within surgical systems. [ABSTRACT FROM AUTHOR]

Published
2023
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38. People in intensive care with COVID ‐19: demographic and clinical features during the first, second, and third pandemic waves in Australia

Author

Begum, Husna, primary, Neto, Ary S, additional, Alliegro, Patricia, additional, Broadley, Tessa, additional, Trapani, Tony, additional, Campbell, Lewis T, additional, Cheng, Allen C, additional, Cheung, Winston, additional, Cooper, D James, additional, Erickson, Simon J, additional, French, Craig J, additional, Litton, Edward, additional, McAllister, Richard, additional, Nichol, Alistair, additional, Palermo, Annamaria, additional, Plummer, Mark P, additional, Rotherham, Hannah, additional, Ramanan, Mahesh, additional, Reddi, Benjamin, additional, Reynolds, Claire, additional, Webb, Steven AR, additional, Udy, Andrew A, additional, and Burrell, Aidan, additional

Published
2022
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39. Diabetes mellitus, glycaemic control, and severe COVID-19 in the Australian critical care setting: A nested cohort study

Author

Plummer, Mark P., primary, Rait, Louise, additional, Finnis, Mark E., additional, French, Craig J., additional, Bates, Samantha, additional, Douglas, James, additional, Bhurani, Mansi, additional, Broadley, Tessa, additional, Trapani, Tony, additional, Deane, Adam M., additional, Udy, Andrew A., additional, Burrell, Aidan J.C., additional, Visser, Adam, additional, Mattke, Adrian, additional, Regli, Adrian, additional, Rashid, Alan, additional, Tabah, Alexis, additional, Walker, Alison, additional, Cheng, Allen, additional, Corley, Amanda, additional, Udy, Andrew, additional, Ramnani, Anil, additional, Eidan, Anthony, additional, DeKeulenaer, Bart, additional, Reddi, Benjamin, additional, Richards, Brent, additional, Knott, Cameron, additional, Moore, Cara, additional, Delzoppo, Carmel, additional, Boschert, Catherine, additional, Tacon, Catherine, additional, French, Craig, additional, Austin, Danielle, additional, Brewster, David, additional, Cooper, David, additional, Crosbie, David, additional, Hawkins, David, additional, Jessen, Edda, additional, Martinez, Eduardo, additional, Fysh, Edward, additional, Litton, Edward, additional, Oberender, Felix, additional, McGain, Forbes, additional, Salt, Gavin, additional, Eastwood, Glenn, additional, Taori, Gopal, additional, White, Hayden, additional, Buscher, Hergen, additional, Seppelt, Ian, additional, Leditschke, Isabel Anne, additional, Young, Janelle, additional, Lavana, Jayshree, additional, Cohen, Jeremy, additional, Lugsdin, Jessica, additional, Botha, John, additional, Santamaria, John, additional, Barrett, Jonathan, additional, Singh, Kasha, additional, Laupland, Kevin, additional, El-Khawas, Khaled, additional, Estensen, Kristine, additional, Deshpande, Kush, additional, White, Kyle, additional, Fitzpatrick, Leigh, additional, Campbell, Lewis, additional, Ramanan, Mahesh, additional, Saxena, Manoj, additional, Kainer, Marion, additional, Kol, Mark, additional, Page, Mark, additional, Plummer, Mark, additional, Sterba, Martin, additional, Anstey, Matthew, additional, Brain, Matthew, additional, Maiden, Matthew, additional, Kilminster, Myrene, additional, Hammond, Naomi, additional, Bhadange, Neeraj, additional, Humphreys, Nicole, additional, Jain, Paras, additional, Azzi, Paul, additional, Secombe, Paul, additional, Lister, Paula, additional, Chan, Peter, additional, McCanny, Peter, additional, Britton, Phillip, additional, Janin, Pierre, additional, Krishnamurthy, Ravi, additional, Sonawane, Ravikiran, additional, Tiruvoipati, Ravindranath, additional, Totaro, Richard, additional, Bellomo, Rinaldo, additional, Sanghavi, Ritesh, additional, Peake, Sandra, additional, Bihari, Shailesh, additional, George, Shane, additional, Erickson, Simon, additional, Webb, Steve, additional, Arora, Subhash, additional, Ganu, Subodh, additional, Rozen, Thomas, additional, McKenna, Toni, additional, Kadam, Umesh, additional, Nayyar, Vineet, additional, Choy, Wei Han, additional, and Albassam, Wisam, additional

Published
2022
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42. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation:A Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Lansink-Hartgring, Annemieke Oude, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Taccone, Fabio Silvio, Brasseur, Alexandre, Dauwe, Dieter F., de Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Lansink-Hartgring, Annemieke Oude, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Taccone, Fabio Silvio, Brasseur, Alexandre, Dauwe, Dieter F., de Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., and Vlaar, Alexander P.J.

Abstract

OBJECTIVES: In the general critical care patient population, restrictive transfusion regimen of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients on venovenous extracorporeal membrane oxygenation, guidelines suggest liberal thresholds, and a clear overview of RBC transfusion practice is lacking. This study aims to create an overview of RBC transfusion in venovenous extracorporeal membrane oxygenation. DESIGN: Mixed method approach combining multicenter retrospective study and survey. SETTING: Sixteen ICUs worldwide. PATIENTS: Patients receiving venovenous extracorporeal membrane oxygenation between January 2018 and July 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the proportion receiving RBC, the amount of RBC units given daily and in total. Furthermore, the course of hemoglobin over time during extracorporeal membrane oxygenation was assessed. Demographics, extracorporeal membrane oxygenation characteristics, and patient outcome were collected. Two-hundred eight patients received venovenous extracorporeal membrane oxygenation, 63% male, with an age of 55 years (45–62 yr), mainly for acute respiratory distress syndrome. Extracorporeal membrane oxygenation duration was 9 days (5–14 d). Prior to extracorporeal membrane oxygenation, hemoglobin was 10.8g/dL (8.9–13.0g/dL), decreasing to 8.7g/dL (7.7–9.8g/dL) during extracorporeal membrane oxygenation. Nadir hemoglobin was lower on days when a transfusion was administered (8.1g/dL [7.4–9.3g/dL]). A vast majority of 88% patients received greater than or equal to 1 RBC transfusion, consisting of 1.6 U (1.3–2.3 U) on transfusion days. This high transfusion occurrence rate was also found in nonbleeding patients (81%). Patients with a liberal transfusion threshold (hemoglobin > 9g/dL) received more RBC in total per transfusion day and extracorporeal membrane oxygenation day. No differences in survival, hemorrhagic and thrombotic complication rates

Published
2022

43. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Silvio Taccone, Fabio, Brasseur, Alexandre, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Silvio Taccone, Fabio, Brasseur, Alexandre, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., and Vlaar, Alexander P.J.

Published
2022

46. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, primary, Karami, Mina, additional, van den Bergh, Walter M., additional, Oude Lansink-Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Scholten, Erik, additional, Overmars, Martijn, additional, Silvio Taccone, Fabio, additional, Brasseur, Alexandre, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Hermans, Greet, additional, Meersseman, Philippe, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, Ivancan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, de Bruin, Sanne, additional, Lagrand, Wim K., additional, Henriques, José P. S., additional, Broman, Lars M., additional, and Vlaar, Alexander P. J., additional

Published
2022
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47. Additional file 10 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Author

Ryan, Feargal J., Hope, Christopher M., Masavuli, Makutiro G., Lynn, Miriam A., Mekonnen, Zelalem A., Yeow, Arthur Eng Lip, Garcia-Valtanen, Pablo, Al-Delfi, Zahraa, Gummow, Jason, Ferguson, Catherine, O���Connor, Stephanie, Reddi, Benjamin A. J., Hissaria, Pravin, Shaw, David, Kok-Lim, Chuan, Gleadle, Jonathan M., Beard, Michael R., Barry, Simon C., Grubor-Bauk, Branka, and Lynn, David J.

Abstract

Additional file 10. Symptom questionnaire sent to patients to assess presence of long COVID associated symptoms.

Published
2022
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48. Additional file 3 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Author

Ryan, Feargal J., Hope, Christopher M., Masavuli, Makutiro G., Lynn, Miriam A., Mekonnen, Zelalem A., Yeow, Arthur Eng Lip, Garcia-Valtanen, Pablo, Al-Delfi, Zahraa, Gummow, Jason, Ferguson, Catherine, O���Connor, Stephanie, Reddi, Benjamin A. J., Hissaria, Pravin, Shaw, David, Kok-Lim, Chuan, Gleadle, Jonathan M., Beard, Michael R., Barry, Simon C., Grubor-Bauk, Branka, and Lynn, David J.

Abstract

Additional file 3: Figure S3: Adjusting for differences in immune cell populations. We repeated the differential expression analysis multiple times, each time adjusting for differences in the frequency of major immune cell populations among individuals. Each panel shows the enrichment of selected pathways (same as those shown in Fig. 4F) among genes identified as being significantly up-regulated in each analysis (FDR 1.25-fold). None = no immune cell population adjustment.

Published
2022
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49. Additional file 2 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Author

Ryan, Feargal J., Hope, Christopher M., Masavuli, Makutiro G., Lynn, Miriam A., Mekonnen, Zelalem A., Yeow, Arthur Eng Lip, Garcia-Valtanen, Pablo, Al-Delfi, Zahraa, Gummow, Jason, Ferguson, Catherine, O���Connor, Stephanie, Reddi, Benjamin A. J., Hissaria, Pravin, Shaw, David, Kok-Lim, Chuan, Gleadle, Jonathan M., Beard, Michael R., Barry, Simon C., Grubor-Bauk, Branka, and Lynn, David J.

Abstract

Additional file 2: Figure S2: Expression of genes in two pathways identified as downregulated in COVID-19 convalescents and healthy controls. (A) Reactome pathway R-HSA-76002 ���Platelet activation, signaling and aggregation��� and (B) KEGG pathway hsa00190 ���Oxidative phosphorylation���. Oxidative phosphorylation genes are sub-divided into nuclear and mitochondrially encoded, with the same x axis order of samples in each panel. Only differentially expressed genes (FDR 1.25-fold) within each pathway are shown. (C) Serum CRP levels in samples collected from healthy controls (HC) and COVID-19 convalescent individuals at 12, 16 and 24 weeks post infection.

Published
2022
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50. Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality

Author

Plummer, Mark P., Bellomo, Rinaldo, Cousins, Caroline E., Annink, Christopher E., Sundararajan, Krishnaswamy, Reddi, Benjamin A. J., and Raj, John P.

Subjects
Mortality -- Australia, Glycosylated hemoglobin -- Health aspects, Blood sugar -- Health aspects, Diabetics -- Health aspects, Hyperglycemia -- Health aspects, Health care industry
Abstract

Purpose Hyperglycaemia is common in the critically ill. The objectives of this study were to determine the prevalence of critical illness-associated hyperglycaemia (CIAH) and recognised and unrecognised diabetes in the critically ill as well as to evaluate the impact of premorbid glycaemia on the association between acute hyperglycaemia and mortality. Methods In 1,000 consecutively admitted patients we prospectively measured glycated haemoglobin (HbA.sub.1c) on admission, and blood glucose concentrations during the 48 h after admission, to the intensive care unit. Patients with blood glucose [greater than or equal to]7.0 mmol/l when fasting or [greater than or equal to]11.1 mmol/l during feeding were deemed hyperglycaemic. Patients with acute hyperglycaemia and HbA.sub.1c Results Of 1,000 patients, 498 (49.8 %) had CIAH, 220 (22 %) had recognised diabetes, 55 (5.5 %) had unrecognised diabetes and 227 (22.7 %) were normoglycaemic. The risk of death increased by approximately 20 % for each increase in acute glycaemia of 1 mmol/l in patients with CIAH and those with diabetes and HbA.sub.1c levels Conclusions Critical illness-associated hyperglycaemia is the most frequent cause of hyperglycaemia in the critically ill. Peak glucose concentrations during critical illness are associated with increased mortality in patients with adequate premorbid glycaemic control, but not in patients with premorbid hyperglycaemia. Optimal glucose thresholds in the critically ill may, therefore, be affected by premorbid glycaemia., Author(s): Mark P. Plummer [sup.1] [sup.2], Rinaldo Bellomo [sup.3] [sup.4], Caroline E. Cousins [sup.1], Christopher E. Annink [sup.1], Krishnaswamy Sundararajan [sup.1] [sup.2], Benjamin A. J. Reddi [sup.1] [sup.2], John P. [...]

Published
2014
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