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This research establishes an original clay form - a clay page - that stands apart from traditional clay-based archetypes such as the vessel, the figurine and the tile. The surface treatment and the presentation of the new clay page, formed from porcelain paperclay, all correspond with the language of the paper page. My research asks how this new physical clay page can be developed, and what it might mean. These questions are examined by conducting practice-based investigations. In the studio, the primary research involves tests and compositions in which the clay page corresponds with international paper sizes and the characteristics of the paper page, such as thinness, flatness and lightness. Outside the studio, the research engages in wayfaring (as theorised by Ingold) predominantly in the urban environment of the UK; information is recorded using a camera and brought back to the studio. Layers of coloured slip and glaze are applied to the clay page surface to construct abstract compositions that respond to the clay page form, and which reflect wayfaring. The clay pages are then composed into a group, using the grid, and are presented on the wall. My research explores repetition and variation; grids and edges; borders and framing; levels and layers; lightness and minimality; the ordinary and the everyday; colour and spatial organisation; series and progressions; arrangement and rearrangement; temporality and flexibility. It involves an ethos of working in a self-sufficient manner. The meaning of the clay page and its surface is interpreted as a story of the self, finding a place in the world, seeking joy and freedom within a framework of restricted order and balancing tensions, elevating ordinary, everyday experiences into the extraordinary. The interplay of subject, object and place is grounded in Modernist abstraction and colour theory (Itten) and later theoretical frameworks of the grid (Krauss), the parergon (Derrida) and the overlooked (Bryson). Besides fine art and anthropology, secondary research also draws on poetry, economic theory, philosophy and ceramics. Continual processes of making and material thinking, alone in the street and the studio, are the means by which the new clay archetype develops. Through these collective research procedures, the clay page achieves the aim of the title: a new dimension to the language of ceramics. The research expands the potential of paperclay, ceramic practice and its theorisation, and will be of interest to both specialist and interdisciplinary constituencies.

The main aggrecan catabolite, found in samples of synovial fluid from patients with arthritis, and released from cartilage explant cultures exposed to IL-1, both have the amino-terminal amino acid sequence 374ARGSV ... (human sequence enumeration) corresponding to cleavage at the 'aggrecanase site' within the IGD of aggrecan (Sandy et al., 1992, and Lohmander et al., 1993). Loss of aggrecan is a primary event in the destruction of cartilage in arthritic disease. The Glu373- Ala374 bond ('aggrecanase site') within the IGD of the aggrecan core protein is cleaved by members of the ADAMTS family, including ADAMTS-4 and -5 (Tortorella et al., 1999, Abbaszade et al., 1999, and Sandy et al., 2000). In this investigation the model system of chondrocyte-agarose cultures, pioneered by Aydelotte and Kuettner 1988, was used to study the degradation of aggrecan by ADAMTS-4 and -5 in cartilaginous extracellular matrices. Low molecular weight co-migrating 37kD ADAMTS-4 and -5 isoforms were detected in apparently increased amounts in IL-1 a treated cultures compared to controls. These isoforms were bound by heparin and required de novo protein synthesis in the presence of IL-1 a for their generation. As previously reported, de novo protein synthesis in the presence of IL-1 a was also required for 'IGD aggrecanase activity' (Arner et al., 1998). Heparin bound media fractions from IL- 1a treated cultures possessed 'IGD aggrecanase activity' against exogenous aggrecan, which was inhibited by the amino-terminal region of TIMP-3 and was shown to be due to a 37kD isoform of ADAMTS-4. This implicated low molecular weight isoforms of ADAMTS-4 in the aggrecanolysis detected in the presence of IL-1 a. Carboxy-terminal truncation of furin cleaved ADAMTS-4 has previously been proposed as both an activation mechanism for the enzyme (Pratta et al., 2003, Kashiwagi et al., 2004, Gao et al., 2002, Gao et al., 2004 and Flannery et al., 2002) and a means of deregulation of the enzyme's catalytic activity.( Gao et al., 2002, Gao et al., 2004, and Kashiwagi et al., 2004). Therefore high molecular weight Furin cleaved ADAMTS-4 isoforms may be required to play normal physiological roles, whereas the low molecular weight forms are likely to be the enzyme isoforms involved in the destruction of aggrecan and other proteoglycans in articular cartilage during arthritis.