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737 results on '"Refaat, Marwan"'

6. The Value of Programmed Ventricular Extrastimuli From the Right Ventricular Basal Septum During Supraventricular Tachycardia

Author

Higuchi, Satoshi, Ito, Hiroyuki, Gerstenfeld, Edward P., Lee, Adam C., Lee, Byron K., Marcus, Gregory M., Hsia, Henry H., Moss, Joshua D., Lee, Randall J., Dewland, Thomas A., Vedantham, Vasanth, Tseng, Zian H., Patel, Akash R., Tanel, Ronn E., Badhwar, Nitish, Pellegrini, Cara N., Kawamura, Mitsuharu, Shoda, Morio, Hwang, Chun, Refaat, Marwan M., and Scheinman, Melvin M.

Published
2023
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8. Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes.

Author

Acimovic, Ivana, Refaat, Marwan M, Moreau, Adrien, Salykin, Anton, Reiken, Steve, Sleiman, Yvonne, Souidi, Monia, Přibyl, Jan, Kajava, Andrey V, Richard, Sylvain, Lu, Jonathan T, Chevalier, Philippe, Skládal, Petr, Dvořak, Petr, Rotrekl, Vladimir, Marks, Andrew R, Scheinman, Melvin M, Lacampagne, Alain, and Meli, Albano C

Subjects
CPVT, calcium, flecainide, hiPSC-derived cardiomyocytes, post-translational modifications, ryanodine receptor, β-adrenergic receptor blockade, beta-adrenergic receptor blockade, Clinical Sciences
Abstract

BackgroundSarcoplasmic reticulum Ca2+ leak and post-translational modifications under stress have been implicated in catecholaminergic polymorphic ventricular tachycardia (CPVT), a highly lethal inherited arrhythmogenic disorder. Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease modeling.ObjectiveThe aims were to obtain functional hiPSC-derived cardiomyocytes from a CPVT patient harboring a novel ryanodine receptor (RyR2) mutation and model the syndrome, drug responses and investigate the molecular mechanisms associated to the CPVT syndrome.MethodsPatient-specific cardiomyocytes were generated from a young athletic female diagnosed with CPVT. The contractile, intracellular Ca2+ handling and electrophysiological properties as well as the RyR2 macromolecular remodeling were studied.ResultsExercise stress electrocardiography revealed polymorphic ventricular tachycardia when treated with metoprolol and marked improvement with flecainide alone. We found abnormal stress-induced contractile and electrophysiological properties associated with sarcoplasmic reticulum Ca2+ leak in CPVT hiPSC-derived cardiomyocytes. We found inadequate response to metoprolol and a potent response of flecainide. Stabilizing RyR2 with a Rycal compound prevents those abnormalities specifically in CPVT hiPSC-derived cardiomyocytes. The RyR2-D3638A mutation is located in the conformational change inducing-central core domain and leads to RyR2 macromolecular remodeling including depletion of PP2A and Calstabin2.ConclusionWe identified a novel RyR2-D3638A mutation causing 3D conformational defects and aberrant biophysical properties associated to RyR2 macromolecular complex post-translational remodeling. The molecular remodeling is for the first time revealed using patient-specific hiPSC-derived cardiomyocytes which may explain the CPVT proband's resistance. Our study promotes hiPSC-derived cardiomyocytes as a suitable model for disease modeling, testing new therapeutic compounds, personalized medicine and deciphering underlying molecular mechanisms.

Published
2018

16. NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction: TRANSITION Study

Author

Gniot, Jacek, Mozheiko, Maria, Lelonek, Malgorzata, Dominguez, Antonio Reyes, Horacek, Thomas, Garcia del Rio, Enrique, Kobalava, Zhanna, Mueller, Christian Eugen, Cavusoglu, Yuksel, Straburzynska-Migaj, Ewa, Slanina, Miroslav, vom Dahl, Juergen, Senni, Michele, Ryding, Alisdair, Moriarty, Andrew, Robles, Manuel Beltran, Villota, Julio Nunez, Quintana, Antonio Garcia, Nitschke, Thorsten, Garcia Pinilla, Jose Manuel, Bonet, Luis Almenar, Chaaban, Said, Filali zaatari, Samia, Spinar, Jindrich, Musial, Wlodzimierz, Abdelbaki, Khaled, Belohlavek, Jan, Fehske, Wolfgang, Bott, Michael Carlos, Hoegalmen, Geir, Leiro, Marisa Crespo, Ozcan, Ismail Turkay, Mullens, Wilfried, Kryza, Radim, Al-Ani, Riadh, Loboz-Grudzien, Krystyna, Ermoshkina, Lyudmila, Hojerova, Silvia, Fernandez, Alberto Alfredo, Spinarova, Lenka, Lapp, Harald, Bulut, Efraim, Almeida, Filipa, Vishnevsky, Alexander, Belicova, Margita, Pascual, Domingo, Witte, Klaus, Wong, Kenneth, Droogne, Walter, Delforge, Marc, Peterka, Martin, Olbrich, Hans-Georg, Carugo, Stefano, Nessler, Jadwiga, McGill, Thao Huynh, Huegl, Burkhard, Akin, Ibrahim, Moreira, Ilidio, Baglikov, Andrey, Thambyrajah, Jeetendra, Hayes, Chris, Barrionuevo, Marcelo Raul, Yigit, Zerrin, Kaya, Hakki, Klimsa, Zdenek, Radvan, Martin, Kadel, Christoph, Landmesser, Ulf, Di Tano, Giuseppe, Lisik, Malgorzata Buksinska, Fonseca, Candida, Oliveira, Luis, Marques, Irene, Santos, Luis Miguel, Lenner, Egon, Letavay, Peter, Bueno, Manuel Gomez, Mota, Paula, Wong, Aaron, Bailey, Kristian, Foley, Paul, Hasbani, Eduardo, Virani, Sean, Massih, Tony Abdel, Al-Saif, Shukri, Taborsky, Milos, Kaislerova, Marta, Motovska, Zuzana, Cohen, Aron Ariel, Logeart, Damien, Endemann, Dierk, Ferreira, Daniel, Brito, Dulce, Kycina, Peter, Bollano, Entela, Basilio, Enrique Galve, Rubio, Lorenzo Facila, Aguado, Marcos Garcia, Schiavi, Lilia Beatriz, Zivano, Daniel Francisco, Lonn, Eva, El Sayed, Ali, Pouleur, Anne-Catherine, Heyse, Alex, Schee, Alexandr, Polasek, Rostislav, Houra, Marek, Tribouilloy, Christophe, Seronde, Marie France, Galinier, Michel, Noutsias, Michel, Schwimmbeck, Peter, Voigt, Ingo, Westermann, Dirk, Pulignano, Giovanni, Vegsundvaag, Johnny, Da Silva Antunes, Jose Alexandre, Monteiro, Pedro, Stevlik, Jan, Goncalvesova, Eva, Hulkoova, Beata, Castro Fernandez, Antonio Juan, Davies, Ceri, Squire, Iain, Meyer, Philippe, Sheppard, Richard, Sahin, Tayfun, Sochor, Karel, De Geeter, Guillaume, Wachter, Rolf, Schmeisser, Alexander, Weil, Joachim, Soares, Ana Oliveira, Vasilevna, Olga Bulashova, Oshurkov, Andrey, Sunderland, Shahid Junejo, Glover, Jason, Exequiel, Tomas, Decoulx, Eric, Meyer, Sven, Muenzel, Thomas, Frioes, Fernando, Arbolishvili, Georgy, Tokarcikova, Anna, Karlstrom, Patric, Trullas Vila, Joan Carles, Perez, Gonzalo Pena, Sankaranarayanan, Rajiv, Nageh, Thuraia, Alasia, Diego Cristian, Refaat, Marwan, Demirkan, Burcu, Al-Buraiki, Jehad, Karabsheh, Shadi, Pascual-Figal, Domingo, Bao, Weibin, Noè, Adele, Schwende, Heike, Butylin, Dmytro, and Prescott, Margaret F.

Published
2020
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25. Utility of the Exercise Electrocardiogram Testing in Sudden Cardiac Death Risk Stratification

Author

Refaat, Marwan M, Hotait, Mostafa, and Tseng, Zian H

Subjects
Prevention, Genetics, Cardiovascular, Heart Disease, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Death, Sudden, Cardiac, Electrocardiography, Exercise Test, Humans, Risk Assessment, electrocardiography, electrophysiology, exercise electrocardiogram testing, sudden cardiac arrest, sudden cardiac death, risk stratification, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

BackgroundSudden cardiac death (SCD) remains a major public health problem. Current established criteria identifying those at risk of sudden arrhythmic death, and likely to benefit from implantable cardioverter defibrillators (ICDs), are neither sensitive nor specific. Exercise electrocardiogram (ECG) testing was traditionally used for information concerning patients' symptoms, exercise capacity, cardiovascular function, myocardial ischemia detection, and hemodynamic responses during activity in patients with hypertrophic cardiomyopathy.MethodsWe conducted a systematic review of MEDLINE on the utility of exercise ECG testing in SCD risk stratification.ResultsExercise testing can unmask suspected primary electrical diseases in certain patients (catecholaminergic polymorphic ventricular tachycardia or concealed long QT syndrome) and can be effectively utilized to risk stratify patients at an increased (such as early repolarization syndrome and Brugada syndrome) or decreased risk of SCD, such as the loss of preexcitation on exercise testing in asymptomatic Wolff-Parkinson-White syndrome.ConclusionsExercise ECG testing helps in SCD risk stratification in patients with and without arrhythmogenic hereditary syndromes.

Published
2014

26. Association of CASQ2 polymorphisms with sudden cardiac arrest and heart failure in patients with coronary artery disease

Author

Refaat, Marwan M, Aouizerat, Bradley E, Pullinger, Clive R, Malloy, Mary, Kane, John, and Tseng, Zian H

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Heart Disease - Coronary Heart Disease, Clinical Research, Prevention, Genetics, Heart Disease, 2.1 Biological and endogenous factors, Aetiology, Aged, Arrhythmias, Cardiac, Calsequestrin, Coronary Disease, Death, Sudden, Cardiac, Female, Heart Failure, Humans, Hypertension, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Sudden cardiac arrest, Ventricular arrhythmias, Ventricular tachycardia, Coronary artery disease, Congestive heart failure, Calsequestrin 2, Biomedical Engineering, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundAbnormal calcium handling plays a crucial role in arrhythmias, sudden cardiac arrest (SCA), and congestive heart failure (CHF). Calsequestrin 2 (CASQ2) mutations affect calcium release and initiate malignant ventricular arrhythmias (VAs) and SCA syndromes. Common single nucleotide polymorphisms (SNPs) in CASQ2 may be associated with SCA in patients with coronary artery disease (CAD).ObjectiveThe purpose of this study was to examine the association of common CASQ2 SNPs with the risk of SCA in patients with CAD.MethodsCASQ2 SNPs (n = 14) were genotyped and analyzed in a case control study comparing 114 patients with CAD and SCA due to VA to 311 CAD controls without VA or SCA.ResultsMultivariate logistic regression adjusting for age and CHF status identified an association between rs7521023 with SCA (odds ratio [OR] 2.72, 95% confidence interval [CI] 1.44-5.13, P = .002). The substantial impact of CHF on SCA in the model (OR 26.6, 95% CI 13.40-52.70, P

Published
2014

27. Markers of Right-Sided Heart Failure as Predictors of Chronic Obstructive Pulmonary Disease.

Author

Sleiman, Wissam, Jalloul, Youssef, Zgheib, Ali, Zakharia, Antonios, Makki, Maha, Tamim, Hani, Khalil, Pierre Bou, and Refaat, Marwan M.

Subjects
CHRONIC obstructive pulmonary disease, HEART failure, PULMONARY function tests, ELECTROCARDIOGRAPHY, RIGHT ventricular dysfunction
Abstract

Objectives: Chronic obstructive pulmonary disease (COPD) is an inflammatory disease with systemic manifestations. Heart failure (HF) is the most critical heart condition associated with COPD. Lung diseases are probably associated with right ventricular (RV) dysfunction, but few studies have investigated this. In this study, we identified whether the prevalence of RV dysfunction among patients with COPD is higher than that among patients without COPD. Materials and Methods: In this retrospective cross-sectional study, we included active/former smokers over the age of 40 years with pulmonary function testing (PFT) at the American University of Beirut Medical Center from January to December 2014 and echocardiography within 1 year of the PFT. We classified a total of 135 patients into two groups: a COPD group and a non-COPD control group. Results: COPD was significantly associated with increased odds of increased pulmonary vascular resistance (adjusted odds ratio: 1.99, 95% confidence interval: 1.15-3.46), after adjusting for age, gender, smoking, HF, and diastolic dysfunction. However, COPD was not associated with tricuspid annular plane systolic excursion (p=0.15). Conclusion: Echocardiographic RV dysfunction is associated with COPD. Future prospective research can help put things into perspective and help differentiate COPD severity and projection. [ABSTRACT FROM AUTHOR]

Published
2024
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29. His Bundle Pacing

Author

Vijayaraman, Pugazhendhi, Chung, Mina K., Dandamudi, Gopi, Upadhyay, Gaurav A., Krishnan, Kousik, Crossley, George, Bova Campbell, Kristen, Lee, Byron K., Refaat, Marwan M., Saksena, Sanjeev, Fisher, John D., and Lakkireddy, Dhananjaya

Published
2018
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30. Cardiovascular Therapies Targeting Left Atrial Appendage

Author

Turagam, Mohit K., Velagapudi, Poonam, Kar, Saibal, Holmes, David, Reddy, Vivek Y., Refaat, Marwan M., Di Biase, Luigi, Al-Ahmed, Amin, Chung, Mina K., Lewalter, Thorsten, Edgerton, James, Cox, James, Fisher, John, Natale, Andrea, and Lakkireddy, Dhanunjaya R.

Published
2018
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35. The Muscle-Bound Heart

Author

Refaat, Marwan M., Fahed, Akl C., Hassanieh, Sylvana, Hotait, Mostafa, Arabi, Mariam, Skouri, Hadi, Seidman, Jonathan G., Seidman, Christine E., Bitar, Fadi F., and Nemer, Georges

Published
2016
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49. Effect of Angiotensin-Converting Enzyme Inhibitors and Receptor Blockers on Appropriate Implantable Cardiac Defibrillator Shock in Patients With Severe Systolic Heart Failure (from the GRADE Multicenter Study)

Author

AlJaroudi, Wael A., Refaat, Marwan M., Habib, Robert H., Al-Shaar, Laila, Singh, Madhurmeet, Gutmann, Rebecca, Bloom, Heather L., Dudley, Samuel C., Ellinor, Patrick T., Saba, Samir F., Shalaby, Alaa A., Weiss, Raul, McNamara, Dennis M., Halder, Indrani, and London, Barry

Published
2015
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