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8 results on '"Refici, Marion"'

1. Supplementary Fig. S1 from ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

Author

Ackler, Scott, primary, Xiao, Yu, primary, Mitten, Michael J., primary, Foster, Kelly, primary, Oleksijew, Anatol, primary, Refici, Marion, primary, Schlessinger, Sally, primary, Wang, Baole, primary, Chemburkar, Sanjay R., primary, Bauch, Joy, primary, Tse, Christin, primary, Frost, David J., primary, Fesik, Stephen W., primary, Rosenberg, Saul H., primary, Elmore, Steven W., primary, and Shoemaker, Alex R., primary

Published
2023
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4. Fc[Gamma]-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-[Alpha] levels

Author

REFICI, MARION L., METZGER, DENNIS W., ARULANANDAM, BERNARD P., LENNARTZ, MICHELLE R., and LOEGERING, DANIEL J.

Subjects
Cellular signal transduction -- Physiological aspects, Endotoxins -- Physiological aspects, Tumor necrosis factor -- Analysis, Bacterial infections -- Physiological aspects, Biological sciences
Abstract

Refici, Marion L., Dennis W. Metzger, Bernard P. Arulanandam, Michelle R. Lennartz, and Daniel J. Loegering. Fc[Gamma]-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-[Alpha] levels. Am J Physiol Regulatory Integrative Comp Physiol 280: R1037-R1044, 2001.--The phagocytosis of IgG-coated erythrocytes (EIgG) has been shown to augment the bacterial lipopolysaccharide (LPS)-stimulated increase in serum tumor necrosis factor-[Alpha] (TNF-[Alpha]) levels. The present study evaluated the role of Fc[Gamma]-receptor (Fc[Gamma]R) signaling and complement activation in the effect of EIgG on the TNF-[Alpha] response to LPS. The role of Fc[Gamma]R was determined using FcR [Gamma]-chain knockout mice that lack functional Fc[Gamma]RI and Fc[Gamma]RIII. In wild-type animals, EIgG caused a 16-fold augmentation of the serum TNF-[Alpha] response to LPS, whereas there was no augmentation in the Fc[Gamma]R-deficient animals. Heat-damaged erythrocytes also augmented the TNF-[Alpha] response to LPS. This effect was absent in Fc[Gamma]R-deficient animals. An IgG antibody against heated erythrocytes was detected in mouse serum. The complement activation caused by EIgG had little effect on the LPS-stimulated increase in serum TNF-[Alpha] levels as indicated by activation of complement with cobra venom factor or IgM-coated erythrocytes as well as studies with C5-deficient mice. These results indicate that Fc[Gamma]R signaling primarily mediates the augmented serum TNF-[Alpha] response to LPS caused by EIgG. Fc receptor [Gamma]-chain knockout mice; sepsis; heat-damaged erythrocytes; complement activation; C5 knockout mice; cobra venom factor

Published
2001

5. ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

Author

Ackler, Scott, primary, Xiao, Yu, additional, Mitten, Michael J., additional, Foster, Kelly, additional, Oleksijew, Anatol, additional, Refici, Marion, additional, Schlessinger, Sally, additional, Wang, Baole, additional, Chemburkar, Sanjay R., additional, Bauch, Joy, additional, Tse, Christin, additional, Frost, David J., additional, Fesik, Stephen W., additional, Rosenberg, Saul H., additional, Elmore, Steven W., additional, and Shoemaker, Alex R., additional

Published
2008
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6. Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models

Author

Shoemaker, Alex R., primary, Mitten, Michael J., additional, Adickes, Jessica, additional, Ackler, Scott, additional, Refici, Marion, additional, Ferguson, Debra, additional, Oleksijew, Anatol, additional, O'Connor, Jacqueline M., additional, Wang, Baole, additional, Frost, David J., additional, Bauch, Joy, additional, Marsh, Kennan, additional, Tahir, Steven K., additional, Yang, Xiufen, additional, Tse, Christin, additional, Fesik, Stephen W., additional, Rosenberg, Saul H., additional, and Elmore, Steven W., additional

Published
2008
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7. Antitumor Activity of Orally Bioavailable Farnesyltransferase Inhibitor, ABT-100, Is Mediated by Antiproliferative, Proapoptotic, and Antiangiogenic Effects in Xenograft Models

Author

Ferguson, Debra, primary, Rodriguez, Luis E., additional, Palma, Joann P., additional, Refici, Marion, additional, Jarvis, Kenneth, additional, O'Connor, Jacqueline, additional, Sullivan, Gerard M., additional, Frost, David, additional, Marsh, Kennan, additional, Bauch, Joy, additional, Zhang, Haiying, additional, Lin, Nan-Horng, additional, Rosenberg, Saul, additional, Sham, Hing L., additional, and Joseph, Ingrid B.J.K., additional

Published
2005
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