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1. Amnesia for early life stress does not preclude the adult development of posttraumatic stress disorder symptoms in rats

Author

Poulos, AM, Reger, M, Mehta, N, Zhuravka, I, Sterlace, SS, Gannam, C, Hovda, DA, Giza, CC, and Fanselow, MS

Subjects
Psychiatry, Biological Sciences, Psychology and Cognitive Sciences, Medical and Health Sciences
Abstract

Background Traumatic experience can result in life-long changes in the ability to cope with future stressors and emotionally salient events. These experiences, particularly during early development, are a significant risk factor for later life anxiety disorders such as posttraumatic stress disorder (PTSD). However, because traumatic experience typically results in strong episodic memories, it is not known whether such long-term memories are necessary for particular features of PTSD, such as enhanced fear and anxiety. Here, we used a fear conditioning procedure in juvenile rats before maturation of the neural systems supporting declarative memory to assess the necessity of early memory to the later life development of PTSD-related symptoms. Methods Nineteen-day old rats were exposed to unpredictable and inescapable footshocks, and fear memory for the shock context was assessed during adulthood. Thereafter, adult animals were either exposed to single-trial fear conditioning or elevated plus maze or sacrificed for basal diurnal corticosterone and quantification of neuronal glucocorticoid and neuropeptide Y receptors. Results Early trauma exposed rats displayed stereotypic footshock reactivity, yet by adulthood, hippocampus-dependent contextual fear-related memory was absent. However, adult rats showed sensitized fear learning, aberrant basal circadian fluctuations of corticosterone, increased amygdalar glucocorticoid receptors, decreased time spent in the open arm of an elevated plus maze, and an odor aversion associated with early-life footshocks. Conclusions These results suggest that traumatic experience during developmental periods of hippocampal immaturity can promote lifelong changes in symptoms and neuropathology associated with human PTSD, even if there is no explicit memory of the early trauma. © 2014 Society of Biological Psychiatry.

Published
2014

9. INCIDENT

Author

Reger, M. D.

Published
1962

23. Intranasal insulin improves cognition and modulates -amyloid in early AD

Author

Reger, M. A., primary, Watson, G. S., additional, Green, P. S., additional, Wilkinson, C. W., additional, Baker, L. D., additional, Cholerton, B., additional, Fishel, M. A., additional, Plymate, S. R., additional, Breitner, J.C.S., additional, DeGroodt, W., additional, Mehta, P., additional, and Craft, S., additional

Published
2007
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27. Intranasal insulin improves cognition and modulates -amyloid in early ADSYMBOL

Author

Reger, M A., Watson, G S., Green, P S., Wilkinson, C W., Baker, L D., Cholerton, B, Fishel, M A., Plymate, S R., Breitner, J C.S., DeGroodt, W, Mehta, P, and Craft, S

Abstract

Reduced brain insulin signaling and low CSF-to-plasma insulin ratios have been observed in patients with Alzheimer disease (AD). Furthermore, intracerebroventricular or IV insulin administration improve memory, alter evoked potentials, and modulate neurotransmitters, possibly by augmenting low brain levels. After intranasal administration, insulin-like peptides follow extracellular pathways to the brain within 15 minutes.

Published
2008
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35. A probabilistic model for predicting grain growth processes in alloys

Author

Reti, T, Felde, I, Reger, M, Toth, L, and Fried, Z

Abstract

This paper deals with a possible generalization of the traditional grain growth kinetic functions. A novel probabilistic model devoted to the grain growth prediction in alloys is presented. It is based on the extension of the traditional power law kinetic equation proposed by Beck. The Beck's isothermal kinetic equation is defined as D(t)=A*exp(-E/RT)*tm where D(t) is the grain size (diameter), t is the time, E is the activation energy, A is the preexponential factor, m is the time exponent, R is the universal gas constant and T is the absolute temperature. The novel probabilistic model proposed is based on the concept of the mixture of probability density functions. In this model it is assumed that during grain growth the activation energy (E) is not constant, but its distribution is determined by the initial grain morphology of alloys. More exactly speaking, it is supposed that the activation energy is a random variable which is characterized by the probability density function g(E) of the activation energy. By using appropriately selected probability density functions, different types of generalized grain growth kinetic equations can be established. Based on computer simulations, the application of the extended grain growth kinetic models is demonstrated by examples.

Published
2019

36. Centerline inhomogeneity of flat products

Author

Reger, M, Fabian, E R, and Toth, L

Abstract

Defect free casting requires an excellent accordance between steel properties being cast and the technological parameters, especially from the aspect of inner quality and homogeneity of cast products. Typical serious defects of cast slabs is the centerline segregation (CLS). The centerline segregation in slabs develops in a very complicated way, the main factors influencing the CLS pattern are the macrosegregation and the shrinkage of solidifying melt in the mushy area. The centerline section of the slab can be characterized by different chemical composition compared to the average composition and it can contain shrinkage holes, discontinuities and inclusions. In the hot rolling process the complex shape of interdendritic holes will be modified depending on the strain applied. In chemical composition the difference remains and it can be identified even after the soaking period (over 1050 degC). As an example, the center part of an St52 grade hot rolled heavy plates and strips containing CLS can be characterized by a carbon content of 0,3-0,5 wt% and manganese content of 1,7-1,9 wt%. The segregation level - including the carbon content - can hardly be decreased by post heat treatment or annealing.

Published
2019

38. On the possible generalization of JMAK-type kinetic functions

Author

Reti, T, Deus, A M, Felde, I, and Reger, M

Abstract

The Johnson-Mehl-Avrami-Kolmogorov (JMAK) kinetic equation is generally used for describing the progress of solid state diffusion-controlled transformations. The traditional JMAK model is applicable for modeling only monophase decomposition (precipitation) processes. This paper deals with possible generalizations of the classical JMAK kinetic model by taking into consideration the simultaneous occurrence of more parallel transformations. It is revealed that the Jones-Bhadeshia kinetic model belonging to the family of the strongly coupled multiphase models has only a limited practical application because it contains only few fitting parameters. Moreover, it has been shown and demonstrated that for predicting decomposition processes it is more advantageous to use a multiphase kinetic model including a finite set of ordinary autonomous differential equations.

Published
2018

39. Comprehensive analysis of local corrosion degradation on austenitic pipeline

Author

Trampus, P, Dobranszky, J, Kerner, Z, Knisz, J, Oszvald, F, Palotas, B, Peter, L, Reger, M, and Vero, B

Abstract

Corrosion degradation was observed in a nuclear power plant spent fuel cooling system. A systematic and comprehensive investigation program was developed to reveal the root cause of the degradation. Series of corrosion tests, mechanical, microstructural and microbiological investigations were carried out. Also, simulations of the operating conditions and welding parameters were performed. Based on the results, the major contributors to the degradation process were identified and a possible degradation mechanism was proposed.

Published
2018

41. Verkehrsbeleuchtung

Author

Hagemann, Wilhelm, Krautschneider, Franz, Ganz, Walter, Jaeckel, Georg, Besser, Erwin, Meyer, Gustav, Born, Fritz, Sewig, Rudolf, Lossagk, Helmut, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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42. Entwurf und Eigenschaften von Leuchten

Author

Sewig, Rudolf, Hagemann, Wilhelm, Krautschneider, Franz, Laue, Gustav, Riedel, Heinrich, Schering, Helmuth, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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43. Lichtreklame

Author

Wiegand, Kurt, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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44. Raumbeleuchtung

Author

Wittig, Ernst, Lackner, Kurt, Werner, Max, Richter, Manfred, Steppacher, Richard, Hiepe, Hans, Kurth, Johannes, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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45. Entwurf von Beleuchtungsanlagen

Author

Arndt, Wilhelm, Lux, Heinrich, Hagemann, Wilhelm, Pahl, Arno, Kell, Rudolf, Beckmann, Alfred, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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46. Lichttherapie

Author

Pfleiderer, Heinrich, Rüttenauer, Alfred, Petzold, Wolfgang, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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47. Lichtmessung

Author

Zeiss, Erich, Dziobek, Walter, Dresler, Albert, Richter, Manfred, Korte, Heinrich, Sewig, Rudolf, Petzold, Wolfgang, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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48. Lichtquellen

Author

Lax, Ellen, Rompe, Robert, Reeb, Otto, Shering, Helmuth, Ewest, Hans, Krefft, Hermann, Larché, Kurt, Reger, Martin, Rüttenauer, Alfred, Alberts, Ernst, Dresler, Albert, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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49. Lichttechnische Baustoffe

Author

Schönborn, Herbert, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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50. Einleitung

Author

Lux, Heinrich, Reeb, Otto, Alberts, E., editor, Arndt, W., editor, Beckmann, A., editor, Besser, E., editor, Born, F., editor, Dresler, A., editor, Dziobek, W., editor, Ewest, H., editor, Ganz, W., editor, Hagemann, W., editor, Hiepe, E., editor, Jaeckel, G., editor, Kell, R., editor, Korte, H., editor, Krautschneider, F., editor, Krefft, H., editor, Kurth, J., editor, Lackner, K., editor, Larché, K., editor, Laue, G., editor, Lax, E., editor, Lossagk, H., editor, Lux, H., editor, Meyer, G., editor, Pahl, A., editor, Petzold, W., editor, Pfleiderer, R., editor, Reeb, O., editor, Reger, M., editor, Richter, M., editor, Riedel, H., editor, Rompe, R., editor, Rüttenauer, A., editor, Schering, H., editor, Schönborn, H., editor, Sewig, Rudolf, editor, Steppacher, R., editor, Werner, M., editor, Wiegand, K., editor, Wittig, E., editor, and Zeiss, E., editor

Published
1938
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