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31 results on '"Regidor, Carmen"'

1. Haplo-Cord Transplantation Using CD34+ Cells from a Third-Party Donor to Speed Engraftment in High-Risk Patients with Hematologic Disorders

Author

Kwon, Mi, Bautista, Guiomar, Balsalobre, Pascual, Sánchez-Ortega, Isabel, Serrano, David, Anguita, Javier, Buño, Ismael, Fores, Rafael, Regidor, Carmen, García Marco, José A., Vilches, Carlos, de Pablo, Rosario, Fernández, Manuel N., Gayoso, Jorge, Duarte, Rafael, Díez-Martín, José Luis, and Cabrera, Rafael

Published
2014
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3. Haematopoietic transplants combining a single unrelated cord blood unit and mobilized haematopoietic stem cells from an adult HLA-mismatched third party donor.: Comparable results to transplants from HLA-identical related donors in adults with acute leukaemia and myelodysplastic syndromes

Author

Sebrango, Ana, Vicuña, Isabel, de Laiglesia, Almudena, Millán, Isabel, Bautista, Guiomar, Martín-Donaire, Trinidad, Regidor, Carmen, Cabrera, Rafael, and Fernandez, Manuel N.

Published
2010
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4. Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults

Author

Gonzalo-Daganzo, Rosa, Regidor, Carmen, Martín-Donaire, Trinidad, Rico, Miguel Angel, Bautista, Guiomar, Krsnik, Isabel, Forés, Rafael, Ojeda, Emilio, Sanjuán, Isabel, García-Marco, José A., Navarro, Belén, Gil, Santiago, Sánchez, Rocío, Panadero, Nuria, Gutiérrez, Yolanda, García-Berciano, Miguel, Pérez, Nuria, Millán, Isabel, Cabrera, Rafael, and Fernández, Manuel N.

Published
2009
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9. Single Cord Blood Unit Plus Third Party Donor Cells (Haplo-Cord) Transplantation Compared to Adult Unrelated Donors in Patients with Acute Leukemia: A Retrospective Case-Control Study

Author

Bautista, Guiomar, primary, Canals, Carmen, additional, Kwon, Mi, additional, Sanchez-Ortega, Isabel, additional, Regidor, Carmen, additional, Balsalobre, Pascual, additional, Bermúdez, Arancha, additional, Rovira, Montserrat, additional, Diez-Martin, José Luis, additional, de Laiglesia, Almudena, additional, Pérez-Simón, José Antonio, additional, Yañez, Lucrecia, additional, Ferrá, Christelle, additional, Sierra, Jorge, additional, Bello, Jose Luis, additional, Herrera-Arroyo, Inmaculada, additional, Solano, Carlos, additional, Pascual, Maria Jesús, additional, Zudaire, Teresa, additional, López-Corral, Lucía, additional, Figuera, Angela, additional, Heras, Inmaculada, additional, Sureda, Anna, additional, Cabrera, Rafael, additional, and Duarte, Rafael F., additional

Published
2018
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10. Single umbilical cord blood with or without CD34+ cells from a third-party donor in adults with leukemia

Author

Sanz, Jaime, primary, Kwon, Mi, additional, Bautista, Guiomar, additional, Sanz, Miguel A., additional, Balsalobre, Pascual, additional, Piñana, José Luis, additional, Solano, Carlos, additional, Duarte, Rafael, additional, Ferrá, Christelle, additional, Lorenzo, Ignacio, additional, Martín, Carmen, additional, Barba, Pere, additional, Pascual, María Jesús, additional, Martino, Rodrigo, additional, Gayoso, Jorge, additional, Buño, Ismael, additional, Regidor, Carmen, additional, de la Iglesia, Almudena, additional, Montoro, Juan, additional, Díez-Martín, José Luis, additional, Sanz, Guillermo F., additional, and Cabrera, Rafael, additional

Published
2017
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11. Comparison of Single Unmanipulated Umbilical Cord Blood or Co-Infusion of an Umbilical Cord Blood Graft with CD34+ Cells From a Third Party Donor in Adults with Acute Leukemia

Author

Sanz, Jaime, primary, Kwon, Mi, additional, Bautista, Guiomar, additional, Sanz, Miguel A., additional, Balsalobre, Pascual, additional, Piñana, José Luis, additional, Solano, Carlos, additional, Duarte, Rafael F., additional, Ferrá, Christelle, additional, Martín, Carmen, additional, Barba, Pere, additional, Pascual, Maria Jesús, additional, Martino, Rodrigo, additional, Gayoso, Jorge, additional, Regidor, Carmen, additional, de la Iglesia, Almudena, additional, Montoro, Juan, additional, Diez-Martin, José Luis, additional, Sanz, Guillermo, additional, and Cabrera, Rafael, additional

Published
2017
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12. 204 - Single Cord Blood Unit Plus Third Party Donor Cells (Haplo-Cord) Transplantation Compared to Adult Unrelated Donors in Patients with Acute Leukemia: A Retrospective Case-Control Study

Author

Bautista, Guiomar, Canals, Carmen, Kwon, Mi, Sanchez-Ortega, Isabel, Regidor, Carmen, Balsalobre, Pascual, Bermúdez, Arancha, Rovira, Montserrat, Diez-Martin, José Luis, de Laiglesia, Almudena, Pérez-Simón, José Antonio, Yañez, Lucrecia, Ferrá, Christelle, Sierra, Jorge, Bello, Jose Luis, Herrera-Arroyo, Inmaculada, Solano, Carlos, Pascual, Maria Jesús, Zudaire, Teresa, López-Corral, Lucía, Figuera, Angela, Heras, Inmaculada, Sureda, Anna, Cabrera, Rafael, and Duarte, Rafael F.

Published
2018
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13. 138 - Comparison of Single Unmanipulated Umbilical Cord Blood or Co-Infusion of an Umbilical Cord Blood Graft with CD34+ Cells From a Third Party Donor in Adults with Acute Leukemia

Author

Sanz, Jaime, Kwon, Mi, Bautista, Guiomar, Sanz, Miguel A., Balsalobre, Pascual, Piñana, José Luis, Solano, Carlos, Duarte, Rafael F., Ferrá, Christelle, Martín, Carmen, Barba, Pere, Pascual, Maria Jesús, Martino, Rodrigo, Gayoso, Jorge, Regidor, Carmen, de la Iglesia, Almudena, Montoro, Juan, Diez-Martin, José Luis, Sanz, Guillermo, and Cabrera, Rafael

Published
2017
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14. Paroxysmal Nocturnal Hemoglobinuria and Cancer: High Incidence Of Cancer In a Large Series Of PNH Patients In a Single Center

Author

Muñoz-Linares, Cristina, primary, Ojeda, Emilio, additional, Fores, Rafael, additional, Cabero, Martin, additional, Morillo, Daniel, additional, Bautista, Guiomar, additional, Navarro, Belen, additional, Krsnik, Isabel, additional, Gil, Santiago, additional, de LaIglesia, Almudena, additional, Regidor, Carmen, additional, Bueno, Jose Luis, additional, Garcia-Marco, Jose A, additional, and Cabrera, Jose Rafael, additional

Published
2013
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15. Paroxysmal Nocturnal Hemoglobinuria and Thrombosis Before and After Eculizumab

Author

Muñoz-Linares, Cristina, primary, Pastrana, Miguel, additional, Ojeda, Emilio, additional, Fores, Rafael, additional, Cabero, Martin, additional, Morillo, Daniel, additional, Bautista, Guiomar, additional, Navarro, Belen, additional, Krsnik, Isabel, additional, Gil, Santiago, additional, Regidor, Carmen, additional, de LaIglesia, Almudena, additional, Bueno, Jose Luis, additional, Garcia-Marco, Jose A, additional, and Cabrera, Jose Rafael, additional

Published
2013
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16. Paroxysmal Nocturnal Hemoglobinuria and Magnetic Resonance Imaging

Author

Pastrana, Miguel, primary, Muñoz-Linares, Cristina, additional, Ojeda, Emilio, additional, Fores, Rafael, additional, Brea, Beatriz, additional, Cabero, Martin, additional, Morillo, Daniel, additional, Bautista, Guiomar, additional, Navarro, Belen, additional, Krsnik, Isabel, additional, de LaIglesia, Almudena, additional, Gil, Santiago, additional, Regidor, Carmen, additional, Bueno, Jose Luis, additional, Garcia-Marco, Jose A, additional, and Cabrera, Jose Rafael, additional

Published
2013
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17. Single umbilical cord blood with or without CD34+cells from a third-party donor in adults with leukemia

Author

Sanz, Jaime, Kwon, Mi, Bautista, Guiomar, Sanz, Miguel A., Balsalobre, Pascual, Piñana, José Luis, Solano, Carlos, Duarte, Rafael, Ferrá, Christelle, Lorenzo, Ignacio, Martín, Carmen, Barba, Pere, Pascual, María Jesús, Martino, Rodrigo, Gayoso, Jorge, Buño, Ismael, Regidor, Carmen, de la Iglesia, Almudena, Montoro, Juan, Díez-Martín, José Luis, Sanz, Guillermo F., and Cabrera, Rafael

Abstract

We retrospectively compared the clinical outcomes of adults with acute leukemia who received single-unit umbilical cord blood (UCB) transplantation (sUCBT) (n = 135) or stem cell transplant using coinfusion of a UCB graft with CD34+cells from a third-party donor (Haplo-Cord) (n = 72) at different institutions within the Grupo Español de Trasplante Hematopoyético. In multivariable analysis, patients in the Haplo-Cord group showed more rapid neutrophil (hazard ratio [HR], 2.3; 95% confidence interval [CI], 1.5-3.3; P< .001) and platelet recovery (HR, 1.6; 95% CI, 1.2-2.3; P= .015) and lower incidence of chronic graft-versus-host disease (GVHD) (relative risk, 0.5; 95% CI, 0.3-0.8; P= .01). Nonrelapse mortality, relapse, disease-free survival (DFS), and GVHD/relapse-free survival were similar in the 2 groups. Regarding disease-specific outcomes, DFS in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients was not significantly different; however, a significantly higher relapse rate was found in patients with AML treated with Haplo-Cord (HR, 2.3; 95% CI, 1-5.4; P= .04). Our study confirms that Haplo-Cord was an effective strategy to accelerate neutrophil and platelet recovery and shows that, in the context of specific treatment platforms, sUCBT and Haplo-Cord offer similar long-term outcomes.

Published
2017
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18. Use of Romiplostim to Facilitate Platelet Engraftment in Allogeneic Hematopoietic Transplantation

Author

Ojeda, Emilio, primary, Garcia-Marco, Jose A., additional, Navarro, Belen, additional, DelaIglesia, Almudena, additional, Fores, Rafael, additional, Bautista, Guiomar, additional, Krsnik, Isabel, additional, Sanchez-Guerrero, Amelia, additional, SanJuan, Isabel, additional, Regidor, Carmen, additional, Gil, Santiago, additional, Gonzalo-Daganzo, Rosa, additional, Martin-Donaire, Trinidad, additional, Sanchez, Rocio, additional, Bravo, Gracia, additional, Claros, Nuria, additional, Cabero, Martin, additional, Beltran, Pilar, additional, and Cabrera, Jose Rafael, additional

Published
2011
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19. Analysis of Procoagulants Phospholipids in Plasma of Paroxysmal Nocturnal Hemoglobinuria Patients,Processed in Differents Preanalytic Conditions

Author

Muñoz, Cristina, primary, Garcia-Marco, Jose A, additional, Gil, Santiago, additional, Ojeda, Emilio, additional, Fores, Rafael, additional, Bautista, Guiomar, additional, Krsnik, Isabel, additional, Navarro, Belen, additional, de LaIglesia, Almudena, additional, San Juan, Isabel, additional, Regidor, Carmen, additional, Millan, Isabel, additional, Cabrera, Jose Rafael, additional, Piris, Miguel, additional, Santero, Mirian, additional, Claros, Nuria, additional, Beltran, Pilar, additional, Cabero, Martin, additional, Morillo, Daniel, additional, Martin, Trinidad, additional, Gonzalo, Rosa, additional, and Azcoitia, Beatriz, additional

Published
2011
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20. Use of Third Party Ancillary Cells for Enhancement of Full Donor Chimerism and Immunomodulation in Cord Blood Transplants.

Author

Fernandez, Manuel N., primary, Cabrera, Jose R., additional, Regidor, Carmen, additional, Bautista, Guiomar, additional, Ojeda, Emilio, additional, Fores, Rafael, additional, Sanjuan, Isabel, additional, Ruiz, Elena, additional, Gil, Santiago, additional, Gonzalo, Rosa, additional, Millan, Isabel, additional, Krsnik, Isabel, additional, Navarro, Belen, additional, and Garcia-Marco, Jose A., additional

Published
2007
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21. Single Unit Cord Blood Transplant Supported by Third Party Highly Purified Mobilized Hematopoietic Stem Cells: Immune Reconstitution Studies.

Author

Magro, Elena, primary, Gonzalo-Daganzo, Rosa, additional, Martin-Donaire, Trinidad, additional, Sanchez, Rocio, additional, Panadero, Nuria, additional, Cabrera, Rafael, additional, Regidor, Carmen, additional, Garcia-Marco, Jose A., additional, Fores, Rafael, additional, Krsnik, Isabel, additional, Ruiz, Elena, additional, Bautista, Guiomar, additional, Ojeda, Emilio, additional, Sanjuan, Isabel, additional, Vallejo, Carlos, additional, Millan, Isabel, additional, Prieto, Adria, additional, Travers, Paul, additional, Madrigal, Alejandro, additional, and Fernandez, Manuel, additional

Published
2006
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22. Secondary Malignancies after Hematopoietic Stem Cell Transplantation in Patients Treated with Total Body Irradiation.

Author

de la Fuente, Cristina, primary, Berrocal, Maria I., additional, Cabrera, J. Rafael, additional, Regueiro, Carlos A., additional, Fores, Rafael, additional, Regidor, Carmen, additional, Millan, Isabel, additional, Nuñez, Luis, additional, Valcarcel, Francisco, additional, Fernandez, Manuel N., additional, Sanjuan, Isabel, additional, and de la Torre, Alejandro, additional

Published
2005
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23. Post-Engraftment Infections in Adult Patients Transplanted with Single Cord Blood Units Supported by Co-Infusion of Mobilized Purified Hematopoietic Stem Cells from a Third Party Donor.

Author

Cabrera, J. Rafael, primary, Krsnik, Isabel, primary, Fores, Rafael, primary, Ruiz, Elena, primary, Bautista, Guiomar, primary, Navarro, Belen, primary, Gayoso, Jorge, primary, Gil, Santiago, primary, Regidor, Carmen, primary, Sanjuan, Isabel, primary, Ojeda, Emilio, primary, Garcia-Marco, Jose A., primary, and Fernandez, Manuel N., primary

Published
2005
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24. Unrelated Single Cord Blood Transplant Supported by Co-Infusion of a Low Number of Mobilized Peripheral Blood Highly Purified CD34+ Cells from a Third Party Donor after Low Toxicity Myeloablative Conditioning. a Strategy That Makes Cord Blood Transplant Feasible for Most Patients. (An “Allostem” Study).

Author

Fernandez, Manuel N., primary, Regidor, Carmen, additional, Cabrera, Rafael, additional, Magro, Elena, additional, Fores, Rafael, additional, Bautista, Guiomar, additional, Gayoso, Jorge, additional, Ruiz, Elena, additional, Navaro, Belen, additional, Gil, Santiago, additional, Sanjuan, Isabel, additional, and Garcia-Marco, Jose A., additional

Published
2004
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25. Unrelated umbilical cord blood transplants in adults: Early recoveryof neutrophils by supportive co-transplantation of a low number of highlypurified peripheral blood CD34+ cells from an HLA-haploidentical donor

Author

Fernández, Manuel N, primary, Regidor, Carmen, additional, Cabrera, Rafael, additional, Garcı́a-Marco, José A, additional, Forés, Rafael, additional, Sanjuán, Isabel, additional, Gayoso, Jorge, additional, Gil, Santiago, additional, Ruı́z, Elena, additional, Little, Ann-Margaret, additional, McWhinnie, Alasdair, additional, and Madrigal, Alejandro, additional

Published
2003
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28. Unrelated umbilical cord blood transplants in adults: Early recoveryof neutrophils by supportive co-transplantation of a low number of highlypurified peripheral blood CD34+ cells from an HLA-haploidentical donor

Author

Fernández, Manuel N., Regidor, Carmen, Cabrera, Rafael, García-Marco, José A., Forés, Rafael, Sanjuán, Isabel, Gayoso, Jorge, Gil, Santiago, Ruíz, Elena, Little, Ann-Margaret, McWhinnie, Alasdair, and Madrigal, Alejandro

Subjects
*NEUTROPENIA, *BLOOD cells
Abstract

Objective, Methods, and Results. To reduce the period of posttransplant neutropenia and related early morbidity and mortality of cord blood (CB) transplants, we assessed the feasibility of co-infusion of a low number of highly purified peripheral blood CD34+ cells from a related haploidentical donor with a CB graft. Between March 1999 and May 2002, 11 patients with high-risk hematologic malignancies were transplanted using this strategy. The seven patients who received a haploidentical peripheral blood graft and a CB graft from a sibling (6) or the father (1) had prompt recovery (9–17 days, median 10) of the absolute neutrophil count (ANC) to greater than 0.5×109/L. Analysis of DNA polymorphisms showed initial predominance of the haploidentical genotype both in granulocytes and in mononuclear cells, and subsequent progressive replacement by cells of CB genotype until final complete CB chimerism was achieved by patients who survived for sufficient periods of time. The four patients who received maternal haploidentical cells had no significant contribution of these to blood leukocytes, although complete CB chimerism was achieved by three of them and two reached engraftment of the CB on days +20 and +36. Morbidity due to early bacterial or fungal infections was remarkably low in patients with prompt ANC recovery.Conclusion. Our data show that co-infusion of a CB unit and a low number of haploidentical CD34+ cells may result in a shortened period of posttransplant neutropenia. This is likely the result of prompt and transient engraftment of the haploidentical hematopoietic stem cells that may provide the patient antimicrobial protection until the later engraftment of the CBhematopoietic stem cells. [Copyright &y& Elsevier]

Published
2003
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29. Single umbilical cord blood with or without CD34 + cells from a third-party donor in adults with leukemia.

Author

Sanz J, Kwon M, Bautista G, Sanz MA, Balsalobre P, Piñana JL, Solano C, Duarte R, Ferrá C, Lorenzo I, Martín C, Barba P, Pascual MJ, Martino R, Gayoso J, Buño I, Regidor C, de la Iglesia A, Montoro J, Díez-Martín JL, Sanz GF, and Cabrera R

Abstract

We retrospectively compared the clinical outcomes of adults with acute leukemia who received single-unit umbilical cord blood (UCB) transplantation (sUCBT) (n = 135) or stem cell transplant using coinfusion of a UCB graft with CD34 + cells from a third-party donor (Haplo-Cord) (n = 72) at different institutions within the Grupo Español de Trasplante Hematopoyético. In multivariable analysis, patients in the Haplo-Cord group showed more rapid neutrophil (hazard ratio [HR], 2.3; 95% confidence interval [CI], 1.5-3.3; P < .001) and platelet recovery (HR, 1.6; 95% CI, 1.2-2.3; P = .015) and lower incidence of chronic graft-versus-host disease (GVHD) (relative risk, 0.5; 95% CI, 0.3-0.8; P = .01). Nonrelapse mortality, relapse, disease-free survival (DFS), and GVHD/relapse-free survival were similar in the 2 groups. Regarding disease-specific outcomes, DFS in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients was not significantly different; however, a significantly higher relapse rate was found in patients with AML treated with Haplo-Cord (HR, 2.3; 95% CI, 1-5.4; P = .04). Our study confirms that Haplo-Cord was an effective strategy to accelerate neutrophil and platelet recovery and shows that, in the context of specific treatment platforms, sUCBT and Haplo-Cord offer similar long-term outcomes., Competing Interests: Conflict-of-interest disclosure: The authors declare no competing financial interests.

Published
2017
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30. Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third party donor.

Author

Magro E, Regidor C, Cabrera R, Sanjuán I, Forès R, Garcia-Marco JA, Ruiz E, Gil S, Bautista G, Millán I, Madrigal A, and Fernandez MN

Subjects
Adolescent, Adult, Disease-Free Survival, Female, Graft Survival, Graft vs Host Disease prevention & control, Hematologic Neoplasms mortality, Hematopoietic Stem Cell Mobilization, Humans, Immunosuppressive Agents therapeutic use, Living Donors, Male, Middle Aged, Postoperative Complications epidemiology, Postoperative Complications virology, Survival Analysis, Time Factors, Transplantation Chimera, Transplantation Conditioning, Treatment Outcome, Cord Blood Stem Cell Transplantation, Hematologic Neoplasms surgery, Peripheral Blood Stem Cell Transplantation
Abstract

Background and Objectives: Our objective was to improve the outcome of cord blood (CB) transplantation in adults, by overcoming the limitations imposed by the low number of stem cells present in CB units., Design and Methods: We combined single CB units and co-infusion of third party donor (TPD)-derived peripheral blood mobilized hematopoietic stem cells (MHSC) following myeloablative conditioning with reduced extra-hematologic toxicity., Results: Twenty-seven eligible patients with high-risk hematologic malignancies (age 16-60 years, median 29, weight 43-78 Kg, median 67) received CB units (median nucleated cell count 2.37x10(7)/Kg, median CD34+ cells 0.11x10(6)/Kg) co-infused with TPD-derived MHSC (2.30x10(6)/Kg CD34+ cells; <1x10(4)/Kg CD3+ cells). Neutrophil engraftment (>0.5x10(9)/L) occurred 10 days (9-36) post-transplant and was initially of TPD-origin in all patients except for four who received maternal MHSC, and then became of stable CB-origin. Median times to CB-derived neutrophil count >0.5x10(9)/L and full CB-chimerism were 22 and 55 days, respectively. The maximum cumulative incidence for engraftment, CB-engraftment and full CB-chimerism was 0.93 (95%CI: 0.83-1.00). The median time to reach unsupported platelet counts >20x10(9)/L was 33 days, with a maximum cumulative incidence of 0.74 (95%CI: 0.59-0.93). Transplant-related morbidity was associated primarily with non-neutropenic phase infections. Co-infusion of TPD-cells was well tolerated, with only 14.8% of recipients developing acute graft-versus-host disease (grade III-IV) and 20% developing a chronic (limited) form. The predicted 4-year overall survival was 69% for the whole group and 77% for the 23 patients receiving non-maternal TPD., Interpretation and Conclusions: Our strategy offers prompt engraftment with a low rate of complications in a feasible alternative protocol that overcomes the current limitations of a single CB-transplant in adults.

Published
2006

31. Unrelated umbilical cord blood transplants in adults: Early recovery of neutrophils by supportive co-transplantation of a low number of highly purified peripheral blood CD34+ cells from an HLA-haploidentical donor.

Author

Fernández MN, Regidor C, Cabrera R, García-Marco JA, Forés R, Sanjuán I, Gayoso J, Gil S, Ruíz E, Little AM, McWhinnie A, and Madrigal A

Subjects
Adult, Antigens, CD34, Cord Blood Stem Cell Transplantation adverse effects, Cord Blood Stem Cell Transplantation mortality, Female, Graft Survival, Haplotypes, Hematologic Neoplasms complications, Hematologic Neoplasms mortality, Hematologic Neoplasms therapy, Histocompatibility Testing, Humans, Male, Neutropenia prevention & control, Neutrophils cytology, Opportunistic Infections prevention & control, Peripheral Blood Stem Cell Transplantation adverse effects, Peripheral Blood Stem Cell Transplantation mortality, Survival Analysis, Transplantation, Homologous immunology, Cord Blood Stem Cell Transplantation methods, Peripheral Blood Stem Cell Transplantation methods, Transplantation Immunology
Abstract

Unlabelled: OBJECTIVE, METHODS, AND RESULTS: To reduce the period of posttransplant neutropenia and related early morbidity and mortality of cord blood (CB) transplants, we assessed the feasibility of co-infusion of a low number of highly purified peripheral blood CD34+ cells from a related haploidentical donor with a CB graft. Between March 1999 and May 2002, 11 patients with high-risk hematologic malignancies were transplanted using this strategy. The seven patients who received a haploidentical peripheral blood graft and a CB graft from a sibling (6) or the father (1) had prompt recovery (9-17 days, median 10) of the absolute neutrophil count (ANC) to greater than 0.5 x 10(9)/L. Analysis of DNA polymorphisms showed initial predominance of the haploidentical genotype both in granulocytes and in mononuclear cells, and subsequent progressive replacement by cells of CB genotype until final complete CB chimerism was achieved by patients who survived for sufficient periods of time. The four patients who received maternal haploidentical cells had no significant contribution of these to blood leukocytes, although complete CB chimerism was achieved by three of them and two reached engraftment of the CB on days +20 and +36. Morbidity due to early bacterial or fungal infections was remarkably low in patients with prompt ANC recovery., Conclusion: Our data show that co-infusion of a CB unit and a low number of haploidentical CD34+ cells may result in a shortened period of posttransplant neutropenia. This is likely the result of prompt and transient engraftment of the haploidentical hematopoietic stem cells that may provide the patient antimicrobial protection until the later engraftment of the CB hematopoietic stem cells.

Published
2003
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