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Abstract Background Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limited evidence available from diverse populations, as APOE associations with dementia seem to differ by race. Therefore, we aimed to evaluate the pathways linking APOE-ε4 to cognitive abilities through AD and non-AD neuropathology in an autopsy study with an admixed sample. Methods Neuropathological lesions were evaluated following international criteria using immunohistochemistry. Participants were classified into APOE-ε4 carriers (at least one ε4 allele) and non-carriers. Cognitive abilities were evaluated by the Clinical Dementia Rating Scale sum of boxes. Mediation analyses were conducted to assess the indirect association of APOE-ε4 with cognition through AD-pathology, lacunar infarcts, hyaline arteriosclerosis, cerebral amyloid angiopathy (CAA), Lewy body disease (LBD), and TAR DNA-binding protein 43 (TDP-43). Results We included 648 participants (mean age 75 ± 12 years old, mean education 4.4 ± 3.7 years, 52% women, 69% White, and 28% APOE-ε4 carriers). The association between APOE-ε4 and cognitive abilities was mediated by neurofibrillary tangles (β = 0.88, 95% CI = 0.45; 1.38, p

BackgroundHypertension is associated with working memory (WM) impairment. However, the benefits of Cogmed WM training for the hypertensive population are unknown. Therefore, we aimed to evaluate Cogmed’s effects on the WM performance of hypertensive individuals with executive function (EF) impairment.MethodsWe included 40 hypertensive patients (aged 40–70 years, 68% female) with EF impairment. They were randomized in a 1:1 ratio to receive 10 weeks of adaptive Cogmed training or a non-adaptive control training based on online games. The primary outcome was the WM performance. The secondary outcomes were verbal memory, visuospatial ability, executive function, global cognition, and the neuronal activity measured using functional magnetic resonance imaging (fMRI) under two WM task conditions: low (memorization of 4 spatial locations) and high (memorization of 6 spatial locations). An intention-to-treat (ITT) and per-protocol (PP) analysis were performed.ResultsCogmed did not show a significant effect on WM or any other cognitive outcome post-training. However, under the WM-low load and WM-high load conditions of the fMRI, respectively, the Cogmed group had an activation decrease in the right superior parietal lobe (ITT and PP analyses) and left inferior frontal lobe (PP analysis) in comparison to the control group.ConclusionThe Cogmed showed no effects on the WM performance of hypertensive individuals with EF impairment. However, activation decreases were observed in frontoparietal areas related to the WM network, suggesting a more efficient neuronal activity after training.

IntroductionIndividuals with high scores of perceived stress (PS) are more likely to develop arterial hypertension (AH) than those with low levels of stress. In addition to this, AH and stress are both independent risk factors for executive function (EF) impairment and worse quality of life (QoL). Therefore, strategies to control and cope with emotional stress are of paramount importance. However, less is known about the association of PS with EF, QoL, and coping in individuals with hypertension. This study aimed to evaluate the association of PS with EF performance, coping strategies use, and QoL in a sample of hypertensive patients.MethodsWe assessed a group of 45 hypertensive individuals (mean age = 58.42 ± 8.9 years, 71.11% female). The EF evaluation was: Frontal Assessment Battery; Controlled Oral Word Association Test—FAS; Letter-Number Sequencing subtest from the Wechsler Adult Intelligence Scale—Third Edition (WAIS-III); Digit Span subtest from the Wechsler Memory Scale-Revised (WMS-R) and Wisconsin Card Sorting Test. The type and frequency of coping strategies used were measured by the Brief Coping with Experienced Problems Scale (Brief-COPE). The World Health Organization Quality of Life Questionnaire Bref (WHOQOL-bref) was applied to measure QoL. The associations of the PS with EF performance, coping strategies, and QoL were investigated using univariate and multiple linear regression models adjusted for age, sex, education, systolic pressure, and depression symptoms.ResultsIn the multivariate analyses, higher PS was an independent predictor for a lower frequency of emotion-focused strategy use (β = −0.23; p = 0.03). However, PS was not significantly related to EF and Qol in this sample. The lower the PS, the greater the use of emotion-focused coping.ConclusionHypertensive individuals with high PS use less frequently positive emotion-focused coping strategies.

Objetivo: sistematizar estudos brasileiros sobre saúde mental no trabalho de segurança pública no período de 2007 a 2017. Metodologia: buscas em bancos de produção acadêmica nacionais e internacionais de acesso gratuito na internet. Resultados: deparou-se com o predomínio de estudos voltados a servidores ligados à polícia militar e a leituras de gênero e suas repercussões na saúde das trabalhadoras, além de dados epidemiológicos relacionados ao estresse profissional. Conclusão: a noção de valorização do trabalhador desse segmento ainda é recente, com predomínio de estudos segmentados que não se aprofundam em uma abordagem sistêmica, o que abre oportunidade de novos estudos.

ABSTRACT Objective We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods Graves’ disease (GD; n = 181) and Hashimoto’s thyroiditis (HT; n = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet–cell (+) and in 20 anti-pancreatic–cell (-) patients. Results There was a non significant trend for higher prevalence of GADA positivity in GD vs HT (7.2% vs 2% p = 0.06), but the GADA titers were higher in HT. We also did not find a significant difference in IA2 prevalence (0.7% vs 0.0%) between these two groups or compared to the control group. In the subsequent analysis, low FPIR was found in 10% of these patients but without statistical difference for OGTT between pancreatic antibody–positive and –negative patients. Conclusion A trend for greater prevalence of GADA was observed for GD patients than for HT or control. However, the titers of these autoantibodies were higher in HT patients, but there was no significant relation to insulin secretion and glucose tolerance at that moment and stage of autoimmune diseases.

Abstract: Background: The incidence of skin cancer has increased worldwide, particularly melanoma rates, which had a mean development of 2.6 % a year in the last 10 years. The agreement on the relation between long-term or chronic exposure to the sun and the emergence of these neoplasias has made several workers who perform activities exposed to solar radiation to form a risk group for the development of skin cancer, community health agents included. OBJECTIVES: To analyze the prevalence of sunscreen-use-related factors to skin cancer in a labor risk group. METHODOLOGY: Cross-sectional study with community health agents selected through simple random sampling. After collecting data using semi-structured interviews, a descriptive analysis was performed for the qualitative variables, bivariate analysis was employed for checking the association between sunscreen use and sociodemographic, occupational and knowledge about skin variables, and multivariate analysis was conducted to check independent variables associated to sunscreen use. A 5% significance level was used. Results: Of 261 health gents selected, 243 were able to participate in the study. The prevalence rate of sunscreen use was 34.2% (95% CI: 28.2-40.2). Factors associated with sunscreen use were female sex, advanced age, use of sunscreen in situations when the skin got burnt, knowledge of the negative effects of the sun on the skin and skin cancer history. Conclusions: The prevalence found reveals that there is a need for implementing educational strategies in health services regarding photoprotection.

As dificuldades de aprendizagem, os índices de reprovação e a evasão na disciplina de Cálculo Diferencial e Integral (CDI), no Brasil ou no exterior, têm se constituído, cada vez mais, em objeto de investigação em Educação Matemática. Assim, ampliam-se os estudos em busca de compreensão e de metodologias de enfrentamento para este cenário. Nesse sentido, o presente estudo tem como objetivo compreender os procedimentos de resolução de problemas de otimização por estudantes de CDI, observando as possibilidades de construí-los por meio de conceitos e procedimentos do Ensino Médio e CDI. Participaram do estudo 56 estudantes, ingressantes no primeiro e no segundo semestre de 2018, do curso de Matemática, da Universidade de Brasília. Os resultados mostram que os estudantes, em sua maioria, apresentaram dificuldades conceituais em tópicos curriculares do Ensino Médio, entre eles, equações algébricas e funções; alguns perceberam o quanto os conceitos e procedimentos de Ensino Médio podem auxiliar na compreensão de conceitos de CDI. Ademais, os achados da pesquisa explicitam a importância do estudo para a compreensão da conceituação em Matemática dos estudantes ingressantes do curso de modo a possibilitar a reconstrução de alternativas metodológicas para a disciplina de CDI.

Este estudo tem como objetivo explorar a utilização das Tecnologias da Informação e da Comunicação (TIC) nos processos terapêuticos e de aconselhamento.Participaram 251 profissionais, de 7 países,que realizam terapia ou aconselhamento. Os participantes responderam a um questionário on-line. Os resultados revelam que dos que já utilizaram alguma ferramenta on-line 52.97% expressam uma opinião positiva/muito positiva, sendo o email a ferramenta on-line mais utilizada e o computador/smart phone os equipamentos mais utilizados.Os resultados evidenciam que desenvolver novas ferramentas e formação na área pode influenciar positivamente a utilização das TIC, sendo reconhecidas diversas vantagens associadas à sua utilização.

The objective of this study was to determine plant height, total number of leaves, number of live leaves, chemical composition and dry mass production of Stylosanthes cv. Campo Grande at first cut and after 21 days of regrowth at different levels of potassium (K2O) with and without zinc (Zn). The experiment was conducted using a randomized block design in a 4 x 2 factorial scheme consisting of four repetitions. Four levels of K2O (0, 120, 240 and 360 mg/dm3) with and without Zn (0 and 6 mg/dm3) were used. There was no effect of the interaction between K2O and Zn levels on the structural characteristics of Stylosanthes cv. Campo Grande, and no independent effects of the different levels of K2O and Zn were observed. The mean plant height, total number of leaves and number of live leaves were 21.2 cm, 30.2 and 27.2, respectively. Dry mass production did not differ between K2O and Zn levels, with a mean production of 3.7 g/pot. There was also no effect of the interaction between K2O and Zn levels on dry matter and neutral detergent fiber content, and no independent effects of the different levels of K2O and Zn were observed, with mean values of 29.3% and 46.9% dry matter, respectively. However, an effect of the interaction between K2O and Zn levels was observed for crude protein content, which exhibited a quadratic response. Re2growth increased linearly with increasing K2O levels. Although the highest crude protein content was obtained at zero levels of potassium and zinc, potassium fertilization is advantageous since it increases the regrowth of Stylosanthes cv. Campo Grande in 21 days.

O objectivo do presente trabalho foi analisar se atitudes positivas ou favoráveis estão associadas a uma predisposição para a prática da atividade física e do desporto e, por outro lado, se a ausência de prática implica atitudes negativas. Foi constituída uma amostra de 193 indivíduos, dos quais 92 são do sexo masculino e 101 são do sexo feminino, com idades compreendidas entre os 25 e os 50 anos. Recolhemos os dados através de um questionário com base na Escala de Atitudes Face à Atividade Física e ao Desporto (Dosil, 2002) ao qual juntamos duas questões para a medição da prática do exercício físico . O nosso estudo indicou que as atitudes: importância percebida que o sujeito faz da atividade e desporto (Importância Percebida) e a possibilidade de prática de uma atividade física e desporto (Possibilidade de prática de Atividade) estão positivamente correlacionadas com a prática do exercício físico.

O Estado do Mato Grosso (Brasil) possui uma rica diversidade ecológica somado ao mosaico cultural de identidades interatuantes nos territórios. Contudo, muitos grupos sociais estão "invisíveis"ou pouco conhecidos. esta pesquisa tem objetivo de mapear e registrar as identidades dos grupos sociais, portadores de saberes e práticas ambientais relevantes para construção de sociedades sustentáveis. neste artigo apresentamos o registro de 42 grupos sociais somados a 45 etnias indígenas totalizando um prognóstico de 87 identidades mato-grossenses. os resultados aqui apresentados vêm contribuir com a proteção ecológica dos ecossistemas e reforçar o reconhecimento das identidades coletivas que defendem diferentes territorialidades e merecem políticas públicas específicas para a autonomia de suas identidades e de seus territórios.The State of Mato Grosso (Brazil) has a rich ecological diversity added to the cultural mosaic of interacting identities in the territories. However, many social groups are "invisible"or poorly known. This research aims at mapping and registering the identities of the social groups that carry knowledge and environmental practices relevant for the building of sustainable societies. In this article we present the register of 42 social groups added to 45 indigenous ethnic groups totalizing a prognosis of 87 mato-grossense identities. The results presented here contribute for the ecological protection of the ecosystems and reinforce the recognition of the collective identities that defend different territorialities and deserve specific public policies for the autonomy of their identities and their territories.

Este artigo apresenta os caminhos percorridos para construção de uma metodologia de mapeamento participativo elaborada pelo Grupo Pesquisador em Educação Ambiental, Comunicação e Arte (GPEA)3 da UFMT. O Mapa Social busca registrar identidades, territórios e conflitos socioambientais vivenciados pelos grupos sociais por meio das autodenominações e autonarrativas. Torna-se um percurso dialógico importante para a educação ambiental, por evidenciar a relação intrínseca entre cultura-natureza, corroborando com entendimento que a perda de um implica no desaparecimento do outro. Entrelaçados ao percurso metodológico os resultados apresentam o mapeamento realizado no Pantanal Mato-grossense, especificamente, um exemplo de mapa social construído em/por uma comunidade Pantaneira. Palavras-chave: Educação ambiental. Mapa Social. Pantanal/Brasil.

No vasto universo amazônico, direcionamos nosso olhar ao povoado de Guariba, localizado no extremo noroeste de Mato Grosso, uma pequena região habitada por uma miscigenação de etnias e grupos sociais. Inscritos no Projeto Biodiesel Guariba, um convênio entre a Universidade Federal de Mato Grosso (UFMT) e a Eletronorte. Nosso objetivo foi criar oportunidades de responsabilidade ambiental e de empoderamento social comunitário num processo de formação educativa. Inscritos na fenomenologia, neste artigo nosso esforço concentra-se em apresentar a percepção desta comunidade em relação ao processo educativo estabelecidos em seus territórios.