13 results on '"Rei Sunami"'
Search Results
2. Association between the high soluble fms-like tyrosine kinase-1 to placental growth factor ratio and adverse outcomes in asymptomatic women with early-onset fetal growth restriction
- Author
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Satoshi Shinohara, Yuzo Uchida, Mayuko Kasai, and Rei Sunami
- Subjects
angiogenic factors ,birth complications ,early-onset fgr ,placental growth factor (plgf) ,soluble fms-like tyrosine kinase-1 (sflt-1) ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective: To assess whether the high soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is associated with adverse outcomes (e.g., HELLP syndrome [hemolysis, elevated liver enzymes, and low platelets], severe hypertension uncontrolled by medication, non-reassuring fetal status, placental abruption, pulmonary edema, growth arrest, maternal death, or fetal death) and a shorter duration to delivery in early-onset fetal growth restriction (FGR).Methods: Thirty-four women with FGR diagnosed at
- Published
- 2017
- Full Text
- View/download PDF
3. Prevalence of common aneuploidy in twin pregnancies
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Akiko Konishi, Osamu Samura, Jin Muromoto, Yoko Okamoto, Hironori Takahashi, Yasuyo Kasai, Mayuko Ichikawa, Naoki Yamada, Noriko Kato, Hiroshi Sato, Hiromi Hamada, Naoyuki Nakanami, Maya Machi, Kiyotake Ichizuka, Rei Sunami, Toshitaka Tanaka, Naoto Yonetani, Yoshimasa Kamei, Takeshi Nagamatsu, Mariko Matsumoto, Shinya Tairaku, Arisa Fujiwara, Hiroaki Nakamura, Takashi Harada, Takafumi Watanabe, Shoko Sasaki, Satoshi Kawaguchi, Sawako Minami, Masaki Ogawa, Kiyonori Miura, Nobuhiro Suzumori, Junya Kojima, Tomomi Kotani, Rumi Sasaki, Tsukasa Baba, Aya Toyofuku, Masayuki Endo, Naoki Takeshita, Takeshi Taketani, Masakatsu Sase, Keiichi Matsubara, Kei Hayata, Yoshinobu Hamada, Makiko Egawa, Toshiyuki Kakinuma, Sachio Matsushima, Michihiro Kitagawa, Tomomi Shiga, Ryuhei Kurashina, Hironori Hamada, Hiroaki Takagi, Akane Kondo, Norio Miharu, Michiko Yamashita, Madoka Horiya, Keiji Morimoto, Ken Takahashi, Aikou Okamoto, Akihiko Sekizawa, and Haruhiko Sago
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Chromosome Aberrations ,Pregnancy ,Genetics ,Pregnancy, Twin ,Prevalence ,Humans ,Chromosome Disorders ,Female ,Trisomy ,Down Syndrome ,Aneuploidy ,Genetics (clinical) ,Retrospective Studies - Abstract
The incidence of chromosomal abnormalities in twin pregnancies is not well-studied. In this retrospective study, we investigated the frequency of chromosomal abnormalities in twin pregnancies and compared the incidence of chromosomal abnormalities in dichorionic diamniotic (DD) and monochorionic diamniotic (MD) twins. We used data from 57 clinical facilities across Japan. Twin pregnancies of more than 12 weeks of gestation managed between January 2016 and December 2018 were included in the study. A total of 2899 and 1908 cases of DD and MD twins, respectively, were reported, and the incidence of chromosomal abnormalities in one or both fetuses was 0.9% (25/2899) and 0.2% (4/1908) in each group (p = 0.004). In this study, the most common chromosomal abnormality was trisomy 21 (51.7% [15/29]), followed by trisomy 18 (13.8% [4/29]) and trisomy 13 (6.9% [2/29]). The incidence of trisomy 21 in MD twins was lower than that in DD twins (0.05% vs. 0.5%, p = 0.007). Trisomy 21 was less common in MD twins, even when compared with the expected incidence in singletons (0.05% vs. 0.3%, RR 0.15 [95% CI 0.04–0.68]). The risk of chromosomal abnormality decreases in twin pregnancies, especially in MD twins.
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- 2021
4. Distribution of PAPP-A and total hCG between 11 and 13 weeks of gestation in Japanese pregnant women
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Akihiko Sekizawa, Keiichi Matsubara, Akane Kondo, Yoshimasa Kamei, Seiji Wada, Masamitsu Nakamura, Yoko Tateishi, Rei Sunami, Jun Murotsuki, Junichi Hasegawa, Eriko Iwata, Haruhiko Sago, Aiko Sasaki, Miyuki Nishiyama, Atsushi Kasamatsu, Haruka Hamanoue, Masahiko Nakata, Susumu Murata, Atsushi Tajima, and Ryuhei Nagai
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Adult ,medicine.medical_specialty ,Down syndrome ,Chorionic Gonadotropin ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Japan ,Nuchal translucency ,Pregnancy ,Chromosomal Abnormality ,Humans ,Pregnancy-Associated Plasma Protein-A ,Medicine ,Distribution (pharmacology) ,Prospective Studies ,reproductive and urinary physiology ,Crown-rump length ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Reference Standards ,Aneuploidy ,medicine.disease ,Fetal aneuploidy ,Reference values ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,030211 gastroenterology & hepatology ,Down Syndrome ,Nuchal Translucency Measurement ,business - Abstract
Objectives: To establish the reference values for PAPP-A and total hCG between 11 and 13 weeks of gestation for the use of risk assessment of fetal aneuploidy in Japanese pregnant women.Methods: A ...
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- 2018
5. Association between the high soluble fms-like tyrosine kinase-1 to placental growth factor ratio and adverse outcomes in asymptomatic women with early-onset fetal growth restriction
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Mayuko Kasai, Satoshi Shinohara, Rei Sunami, and Yuzo Uchida
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Placental growth factor ,Adult ,medicine.medical_specialty ,HELLP syndrome ,Adverse outcomes ,030204 cardiovascular system & hematology ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Pregnancy ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Tyrosine ,Early onset ,Placenta Growth Factor ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Fetal Growth Retardation ,Vascular Endothelial Growth Factor Receptor-1 ,business.industry ,Obstetrics and Gynecology ,medicine.disease ,Hemolysis ,Endocrinology ,embryonic structures ,Asymptomatic Diseases ,Female ,medicine.symptom ,business ,Soluble fms-like tyrosine kinase-1 - Abstract
To assess whether the high soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is associated with adverse outcomes (e.g., HELLP syndrome [hemolysis, elevated liver enzymes, and low platelets], severe hypertension uncontrolled by medication, non-reassuring fetal status, placental abruption, pulmonary edema, growth arrest, maternal death, or fetal death) and a shorter duration to delivery in early-onset fetal growth restriction (FGR).Thirty-four women with FGR diagnosed at34.0 weeks were recruited. Serum angiogenic marker levels were estimated within 6 hours of a diagnosis of FGR. A receiver operating characteristic curve was used to determine the threshold of the sFlt-1/PlGF ratio to predict adverse outcomes. We used multivariable logistic regression analysis to examine the association between the sFlt-1/PlGF ratio and adverse outcomes. Finally, we used Kaplan-Meier analysis and the log-rank test to assess the probability of delay in delivery.Women who developed adverse outcomes within a week had a significantly higher sFlt-1/PlGF ratio than did those who did not develop complications. A cutoff value of 86.2 for the sFlt-1/PlGF ratio predicted adverse outcomes, with a sensitivity and specificity of 77.8% and 80.0%, respectively. Moreover, 58.4% of women with an sFlt-1/PlGF ratio ≥86.2 versus 9.1% of those with an sFlt-1/PlGF ratio86.2 delivered within a week of presentation (p 0.001). In multivariate analyses, an sFlt-1/PlGF ratio ≥86.2 (adjusted odds ratio 9.52; 95% confidence interval, 1.25-72.8) was associated with adverse maternal and neonatal outcomes.A high sFlt-1/PlGF ratio was associated with adverse outcomes and a shorter duration to delivery in early-onset FGR.
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- 2017
6. USEFULNESS OF CRYOPRECIPITATE IN THE TREATMENT OF MASSIVE OBSTETRICAL HEMORRHAGE
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Shuji Hirata, Hiroji Higuchi, Kazuhiko Hoshi, Yasuhiko Okuda, Eriko Ogasahara, Mayuko Komuro, Rei Sunami, Yuko Nakajima, Hiroko Fukasawa, Mitsue Fushimi, Noriaki Iwao, and Makiko Omori
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medicine.medical_specialty ,business.industry ,Cryoprecipitate ,medicine ,Intensive care medicine ,business - Published
- 2012
7. Fetal cell microchimerism develops through the migration of fetus-derived cells to the maternal organs early after implantation
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Tsutomu Yuminamochi, Kazuhiko Hoshi, Rei Sunami, Mayuko Komuro, and Shuji Hirata
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Male ,Pluripotent Stem Cells ,medicine.medical_specialty ,Immunology ,Population ,Mice, Transgenic ,Biology ,Hysterectomy ,Kidney ,Chimerism ,Streptozocin ,Mice ,Fetus ,Cell Movement ,Pregnancy ,Internal medicine ,medicine ,Animals ,Immunology and Allergy ,Placental Circulation ,Embryo Implantation ,education ,Pancreas ,education.field_of_study ,Obstetrics and Gynecology ,Cell Differentiation ,Microchimerism ,medicine.disease ,Streptozotocin ,Mice, Inbred C57BL ,Diabetes Mellitus, Type 1 ,Endocrinology ,medicine.anatomical_structure ,Liver ,Reproductive Medicine ,Female ,Bone marrow ,Stem cell ,medicine.drug - Abstract
Fetus-derived cells are present in the blood and tissues of the maternal body over a long period of time, even after delivery, resulting in fetal cell microchimerism. The exact process by which fetal cells cross the placental barrier to enter the maternal circulation is unclear. The objective of this paper was to determine the time during pregnancy that fetal cells with multilineage potential migrate to the maternal organs. Wild type female mice were crossbred with male transgenic mice, expressing enhanced green fluorescent protein (EGFP). Total hysterectomies were performed at different time points of pregnancy. On day 60 after surgery, mice were injected with either streptozotocin (STZ) to induce insulin-dependent diabetes mellitus, or vehicle. Detection and quantification of fetal cells were then undertaken in a variety of maternal organs via fluorescent microscopy and quantitative PCR amplification of the gfp transgene. In vehicle control mice, fetal cells were detected only in the maternal bone marrow. However on day 30 after STZ injection, fetal cells were detected not only in bone marrow but also in the maternal pancreas, liver and kidney. Histological analysis showed differentiated fetal cells within the pancreatic acinar cells, hepatocytes and tubular epithelial cells. Their morphological appearance was indistinguishable from their maternal counterparts, and their frequency in these organs was constant, regardless of the timing of hysterectomy. These results indicate that most fetal cells with multilineage potential in maternal tissues migrate to the maternal body early after implantation, and thereafter sustain their population over the long term after delivery.
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- 2010
8. Association between total dose of ritodrine hydrochloride and pulmonary oedema in twin pregnancy: a retrospective cohort study in Japan
- Author
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Rei Sunami, Yuzo Uchida, Shuji Hirata, Kohta Suzuki, and Satoshi Shinohara
- Subjects
Adult ,Tocolytic agent ,medicine.medical_specialty ,Adolescent ,Tocolysis ,Maternal Medicine ,Pulmonary Edema ,Ritodrine Hydrochloride ,Interstitial Lung Disease ,Young Adult ,03 medical and health sciences ,Obstetric Labor, Premature ,0302 clinical medicine ,Japan ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,030212 general & internal medicine ,Twin Pregnancy ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Cesarean Section ,Obstetrics ,business.industry ,Research ,Incidence (epidemiology) ,Retrospective cohort study ,General Medicine ,Middle Aged ,Delivery, Obstetric ,Pulmonary edema ,medicine.disease ,Medical Management ,Logistic Models ,Tocolytic Agents ,ROC Curve ,Ritodrine ,Pregnancy, Twin ,Female ,business ,medicine.drug - Abstract
ObjectivePulmonary oedema is recognised as a severe side effect of ritodrine hydrochloride. Recently, the number of twin pregnancies has been increasing. Few studies have reported the association between total dose of ritodrine hydrochloride prior to delivery and pulmonary oedema in twin pregnancy. We aimed to examine this association and determine the optimal cut-off threshold of total ritodrine hydrochloride dose to predict the incidence of pulmonary oedema in twin pregnancy based on obstetric records.DesignRetrospective cohort study.SettingYamanashi Prefectural Central Hospital, Japan.ParticipantsTwo hundred and twenty-six women with twin pregnancy who delivered at Yamanashi Prefectural Central Hospital between September 2009 and November 2016.MethodsThe obstetric records of the participants were analysed. We defined 1 unit of ritodrine hydrochloride as 72 mg per 24 hours continuous transfusion at 50 µg/min to calculate the dose of ritodrine used for tocolysis.Outcome measuresMultivariable logistic regression analysis was performed to examine the association between total dose of ritodrine hydrochloride used for threatened preterm labour and pulmonary oedema, while controlling for potential confounding factors. Then, a receiver–operating characteristic curve was used to determine the optimal cut-off of total ritodrine dose to predict pulmonary oedema incidence.ResultsMean maternal age was 32 (range, 18–46) years; 143 participants were nulliparous (63.3%), 109 had (48.2%) term deliveries and 194 (85.8%) had caesarean deliveries. The overall incidence of pulmonary oedema was 13.7% (31/226). Multivariable analysis showed that the total dose of ritodrine was significantly associated with pulmonary oedema (adjusted OR 1.02; 95% CI 1.004 to 1.03). The best cut-off point to predict the incidence of pulmonary oedema was 26 units (1872 mg) (sensitivity, 61.3%; specificity, 87.8%).ConclusionOur results suggest that consideration of the total dose of ritodrine hydrochloride is helpful in the management of patients with threatened preterm labour in twin pregnancy.
- Published
- 2017
9. Low adjusted serum ionized calcium concentration shortly after birth predicts poor outcome in neonatal hypoxic-ischemic encephalopathy
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Satoshi Yoneda, Shigeru Saito, Masatoshi Sakai, Kosuke Kobayashi, Yumi Sumida, Tsuyomu Ikenoue, Satoshi Ibara, Rei Sunami, Hideki Maruyama, Yuko Maruyama, and Eiji Kato
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Male ,medicine.medical_specialty ,Necrosis ,Encephalopathy ,chemistry.chemical_element ,Calcium ,Gastroenterology ,Hypoxic Ischemic Encephalopathy ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Calcium metabolism ,Asphyxia Neonatorum ,business.industry ,Infant, Newborn ,Case-control study ,Obstetrics and Gynecology ,medicine.disease ,Surgery ,chemistry ,Case-Control Studies ,Predictive value of tests ,Hypoxia-Ischemia, Brain ,Female ,medicine.symptom ,business ,Reperfusion injury ,Biomarkers - Abstract
Aim: Hypoxic–ischemic reperfusion injury causes either necrosis or apoptosis, and the influx of ionized calcium into cells is the major cause of both types of cell death. The aim of this study was to investigate whether or not the serum ionized calcium concentration in neonates with hypoxic–ischemic encephalopathy (HIE) could be used to predict their outcome. Methods: Serum samples were obtained shortly after birth from 20 HIE neonates who had not urinated or received treatment with calcium. Serum ionized calcium concentrations were adjusted for pH using a correction formula. Twelve neonates without any disease were selected as a control. The results were compared between nine HIE neonates who made a full recovery, 11 who died or had neurologic deficits, and 12 normal neonates. Results: Considered together, the two HIE groups had lower serum ionized calcium concentrations (1.05 ± 0.10 mmol/L) than the control group (1.22 ± 0.07 mmol/L; P
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- 2005
10. Migration of microchimeric fetal cells into maternal circulation before placenta formation
- Author
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Hikaru Tagaya, Mayuko Komuro, Rei Sunami, and Shuji Hirata
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Fetus ,education.field_of_study ,Pregnancy ,Population ,Microchimerism ,Biology ,medicine.disease ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Biochemistry ,Placental barrier ,Article Addendum ,Andrology ,medicine.anatomical_structure ,Placenta ,embryonic structures ,Immunology ,Genetics ,medicine ,Bone marrow ,Maternal body ,education ,Molecular Biology - Abstract
Fetal cell microchimerism is defined as the persistence of pluripotent fetal cells in the maternal body long after delivery. The exact process by which fetal cells cross the placental barrier and enter maternal circulation is still being investigated. We reported that fetal cells persist only in the maternal bone marrow and may give rise to subpopulations with the ability to differentiate into the tissue-specific mature cells within injured maternal organs. Moreover, most of the fetal cells enter the maternal circulation during the early stages of pregnancy. These results indicate that the fetal cells with a multilineage potential, which were detected in a variety of maternal organs during pregnancy did not pass through the placental barrier; rather, they were derived from the fetal cells that entered maternal circulation early after implantation, and sustained their population long after delivery.
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- 2010
11. Association between total dose of ritodrine hydrochloride and pulmonary oedema in twin pregnancy: a retrospective cohort study in Japan.
- Author
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Shinohara, Satoshi, Rei Sunami, Yuzo Uchida, Shuji Hirata, and Kohta Suzuki
- Abstract
Objective Pulmonary oedema is recognised as a severe side effect of ritodrine hydrochloride. Recently, the number of twin pregnancies has been increasing. Few studies have reported the association between total dose of ritodrine hydrochloride prior to delivery and pulmonary oedema in twin pregnancy. We aimed to examine this association and determine the optimal cut-off threshold of total ritodrine hydrochloride dose to predict the incidence of pulmonary oedema in twin pregnancy based on obstetric records. Design Retrospective cohort study. Setting Yamanashi Prefectural Central Hospital, Japan. Participants Two hundred and twenty-six women with twin pregnancy who delivered at Yamanashi Prefectural Central Hospital between September 2009 and November 2016. Methods The obstetric records of the participants were analysed. We defined 1 unit of ritodrine hydrochloride as 72 mg per 24 hours continuous transfusion at 50 μg/min to calculate the dose of ritodrine used for tocolysis. Outcome measures Multivariable logistic regression analysis was performed to examine the association between total dose of ritodrine hydrochloride used for threatened preterm labour and pulmonary oedema, while controlling for potential confounding factors. Then, a receiver–operating characteristic curve was used to determine the optimal cut-off of total ritodrine dose to predict pulmonary oedema incidence. Results Mean maternal age was 32 (range, 18–46) years; 143 participants were nulliparous (63.3%), 109 had (48.2%) term deliveries and 194 (85.8%) had caesarean deliveries. The overall incidence of pulmonary oedema was 13.7% (31/226). Multivariable analysis showed that the total dose of ritodrine was significantly associated with pulmonary oedema (adjusted OR 1.02; 95% CI 1.004 to 1.03). The best cut-off point to predict the incidence of pulmonary oedema was 26 units (1872 mg) (sensitivity, 61.3%; specificity, 87.8%). Conclusion Our results suggest that consideration of the total dose of ritodrine hydrochloride is helpful in the management of patients with threatened preterm labour in twin pregnancy. [ABSTRACT FROM AUTHOR]
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- 2017
- Full Text
- View/download PDF
12. [The role of pregnancy associated progenitor cells in the regeneration of injured maternal organs]
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Rei Sunami, Hikaru Tagaya, and Shuji Hirata
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Genetically modified mouse ,Male ,Immunology ,Population ,Green Fluorescent Proteins ,Mice, Transgenic ,Biology ,Regenerative medicine ,Andrology ,Mice ,Fetus ,medicine ,Immunology and Allergy ,Animals ,Regeneration ,Progenitor cell ,education ,education.field_of_study ,Regeneration (biology) ,Stem Cells ,General Medicine ,medicine.anatomical_structure ,Female ,Bone marrow ,Stem cell - Abstract
Microchimeric fetal cells are present in the maternal body over a long period and thought to have the ability to colonize multiple tissues and organs. They are found in a wide range of maternal tissues affected with variety of diseases, thus, there is a possibility that they may contribute tissue repair and regeneration. To assess their possibility of use in regenerative medicine, we investigated whether fetal cells regenerate infracted maternal organs. We crossbred wild female mice with male transgenic mice, expressing enhanced green fluorescent protein (EGFP), and total hysterectomies were performed at the day 6 of pregnancies. On day 60 after the operations, the mice were injected with streptozotocin (STZ) to induce multiple organs injuries. We also created the ischemic organ injury model ; myocardial infarction model and cerebral infarction model. Detection and quantification of fetal cells were then attempted in a variety of maternal organs via a fluorescent microscope and quantitative PCR amplification of the gfp transgene. Fetal cells were detected only in maternal bone marrow before maternal organs injuries were induced, however, they were detected not only in bone marrow but also in the maternal injured organs. Histological analysis showed that differentiated fetal cells were observed and their morphological appearance was indistinguishable from their maternal counterparts. These results indicate that fetal cells sustained their population in the maternal bone marrow, may have contributed to the maternal tissue regeneration.
- Published
- 2011
13. Microchimeric fetal cells migrate to the maternal injured tissues and trans-differentiate to the organ specific cells without maternal immunological elimination
- Author
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Shuji Hirata and Rei Sunami
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Pathology ,medicine.medical_specialty ,Fetus ,Reproductive Medicine ,business.industry ,Immunology ,Organ specific ,medicine ,Obstetrics and Gynecology ,Immunology and Allergy ,business - Published
- 2010
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