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1. Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39

Author

Kawamura, Masataka, Parmentier, Catherine, Ray, Samrat, Clotet-Freixas, Sergi, Leung, Sharon, John, Rohan, Mazilescu, Laura, Nogueira, Emmanuel, Noguchi, Yuki, Goto, Toru, Arulratnam, Bhranavi, Ganesh, Sujani, Tamang, Tomas, Lees, Kaitlin, Reichman, Trevor W., Andreazza, Ana C., Kim, Peter K., Konvalinka, Ana, Selzner, Markus, and Robinson, Lisa A.

Published
2024
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2. Vascular Resection for Pancreas Cancer – 10-year Experience from a Single High Volume-center

Author

Henault, David, Kunde, Holden, Zatzman, Cody, Bevacqua, Daniela, Arshinoff, Danielle LA., Cleary, Sean P., Dawson, Laura A., Elimova, Elena, Grant, Robert, Hosni, Ali, Jang, Raymond W., Knox, Jennifer J., Mesci, Aruz, Moore, Malcolm, Moulton, Carol-Anne E., Reichman, Trevor W., Shwaartz, Chaya, Tsang, Erica S., McGilvray, Ian D., and Gallinger, Steven

Published
2024
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3. Should advanced donor age be a deterrent in the utilization of grafts from donation after cardiac death in deceased donor liver transplantation? The Toronto experience

Author

Ray, Samrat, Shwaartz, Chaya, Sayed, Blayne Amir, Sapisochin, Gonzalo, Ghanekar, Anand, Mcgilvray, Ian, Cattral, Mark, Lilly, Leslie, Selzner, Nazia, Tsien, Cynthia, Bhat, Mamatha, Jaeckel, Elmar, Selzner, Markus, and Reichman, Trevor W.

Subjects
Gifts -- Usage, Liver -- Transplantation, Heart -- Usage -- Analysis, Health, Health care industry
Abstract

Background: Advanced donor age paired with donation after cardiac death (DCD) increases the risk of transplantation, precluding widespread use of grafts from such donors worldwide. Our aim was to analyze outcomes of liver transplantation using grafts from older DCD donors and donation after brain death (DBD) donors. Methods: Patients who underwent liver transplantation using grafts from deceased donors between January 2016 and December 2021 were included in the study. Short-and long-term outcomes were analyzed for 4 groups of patients: those who received DCD and DBD grafts from younger (< 50 yr) and older ([greater than or equal to] 50 yr) donors. Results: Of the 807 patients included in the analysis, 44.7% (n = 361) of grafts were received from older donors, with grafts for older DCD donors comprising 4.7% of the total cohort (n = 38). Patients who received grafts from older donors had a lower incidence of biliary strictures than those who received grafts from younger donors (7.9% v. 20.0% for DCD donation, p = 0.14, and 4.9% v. 6.8% for DBD donation, p = 0.34), with a significantly lower incidence of ischemic-type biliary strictures in patients who received grafts from older versus younger DCD donors (2.6% v. 18.0%, p = 0.04). There was no difference in 1- and 3-year graft survival rates among patients who received grafts from older and younger DCD donors (92.1% v. 90.8% and 80.2% v. 80.9%, respectively) and those who received grafts from older and younger DBD donors (90.1% v. 93.2% and 85.3% v. 84.4%, respectively) (p = 0.85). Pre-transplantation admission to the intensive care unit (hazard ratio [HR] 9.041, p < 0.001) and nonalcoholic steatohepatitis (HR 2.197, p = 0.02) were found to significantly affect survival of grafts from older donors. Conclusion: Donor age alone should not be the criterion to determine the acceptability of grafts in liver transplantation. With careful selection criteria, older DCD donors could make a valuable contribution to expanding the liver donor pool, with grafts that produce comparable results to those obtained with standard-criteria grafts. Contexte: L'âge avancé du donneur après décès cardiocirculatoire (DDC) accroît le risque lié à la transplantation et empêche l'utilisation à grande échelle de greffons provenant de tels donneurs partout dans le monde. Nous avons voulu analyser l'issue de transplantations de foie provenant de DDC et de donneurs après décès neurologique (DDN). Méthodes: Les malades soumis à une transplantation de foie provenant de donneurs décédés entre janvier 2016 et décembre 2021 ont été inclus dans l'étude. Nous avons analysé l'issue de ces transplantations pour 4 groupes différents : greffons provenant de DDC et de DDN, jeunes (< 50 ans) et âgés ([supérieur ou égal à ] 50 ans). Résultats: Pour les 807 personnes inclus dans l'analyse, 44,7% (n = 361) des greffons provenaient de donneurs âgés, les greffons provenant de DDC âgés représentant 4,7% de la cohorte totale (n = 38). Les personnes ayant reçu des greffons de donneurs âgés ont présenté une incidence moindre de sténose des voies biliaires que les personnes ayant reçu des greffons de donneurs jeunes (DDC : 7,9% c. 20,0%, p = 0,14; DDN : 4,9% c. 6,8%, p = 0,34), avec une incidence significativement moindre de sténose des voies biliaires de type ischémique chez les personnes ayant reçu des greffons de DDC âgés contre jeunes (2,6% c. 18,0%, p = 0,04). On n'a noté aucune différence entre les taux de survie des greffons après 1 et 3 ans chez les personnes ayant reçu des greffons de DDC âgés et jeunes et (92,1% c. 90,8% et 80,2% c. 80,9%, respectivement), et de DDN âgés et jeunes (90,1% c. 93,2% et 85,3% c. 84,4%, respectivement) (p = 0,85). Un séjour dans une unité de soins intensifs (rapport de risque [RR] 9,041, p < 0,001) et la stéatohépatite non alcoolique (RR 2,197, p = 0,02) avant la transplantation ont significativement affecté la survie des greffons provenant de donneurs âgés. Conclusion : En soi, l'âge des donneurs ne devrait pas être un critère pour déterminer l'acceptabilité des foies à transplanter. Moyennant de rigoureux critères de sélection, les DDC âgés contribueraient à élargir appréciablement le bassin de donneurs de foies, et procureraient des greffons susceptibles de générer des résultats comparables à ceux des greffons sélectionnés selon les critères standard., Imbalance between the demand for organs and their availability is a known hindrance to increasing liver transplantation rates across North America and has contributed to long waits for transplantation. (1) [...]

Published
2023
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7. Combining Oxygenated Cold Perfusion With Normothermic Ex Vivo Perfusion Improves the Outcome of Donation After Circulatory Death Porcine Kidney Transplantation

Author

Mazilescu, Laura Ioana, Goto, Toru, John, Rohan, Rosales, Roizar, Ganesh, Sujani, Yu, Frank, Noguchi, Yuki, Kawamura, Masataka, Dezard, Victoria, Gao, Fei, Urbanellis, Peter, Parmentier, Catherine, Konvalinka, Ana, Bagli, Darius J., Reichman, Trevor W., Robinson, Lisa A., and Selzner, Markus

Published
2024
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8. Combining Oxygenated Cold Perfusion With Normothermic Ex Vivo Perfusion Improves the Outcome of Donation After Circulatory Death Porcine Kidney Transplantation

Author

Mazilescu, Laura Ioana, Goto, Toru, John, Rohan, Rosales, Roizar, Ganesh, Sujani, Yu, Frank, Noguchi, Yuki, Kawamura, Masataka, Dezard, Victoria, Gao, Fei, Urbanellis, Peter, Parmentier, Catherine, Konvalinka, Ana, Bagli, Darius J., Reichman, Trevor W., Robinson, Lisa A., and Selzner, Markus

Published
2023
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11. Evolving Trends in the Management of Duodenal Leaks After Pancreas Transplantation: A Single-Centre Experience.

Author

Ray, Samrat, Hobeika, Christian, Norgate, Andrea, Sawicka, Zaneta, Schiff, Jeffrey, Sapisochin, Gonzalo, McGilvray, Ian D., Selzner, Markus, Reichman, Trevor W., and Shwaartz, Chaya

Subjects
PANCREAS transplantation, GRAFT survival, INTERVENTIONAL radiology, PANCREATECTOMY, MULTIVARIATE analysis
Abstract

Duodenal leaks (DL) contribute to most graft losses following pancreas transplantation. However, there is a paucity of literature comparing graft preservation approach versus upfront graft pancreatectomy in these patients. We reviewed all pancreas transplants performed in our institution between 2000 and 2020 and identified the recipients developing DL to compare based on their management: percutaneous drainage vs. operative graft preservation vs. upfront pancreatectomy. Of the 595 patients undergoing pancreas transplantation, 74 (12.4%) developed a duodenal leak with a median follow up of 108 months. Forty-five (61%) were managed by graft preservation strategies, with the rest being treated with upfront graft pancreatectomy. DL managed by graft preservation strategies had similar graft survival rates at 1 and 5-year compared to the matched cohort of population without DL (95% and 59% vs. 91% and 62%; p = 0.78). Multivariate analysis identified male recipient (OR: OR: 6.18; CI95%: 1.26–41.09; p = 0.04) to have higher odds of undergoing an upfront graft pancreatectomy. In appropriately selected recipients with DL, graft preservation strategies utilizing either interventional radiology guided percutaneous drainage or laparotomy with/without repair of leak can achieve comparable long-term graft survival rates compared to recipients without DL. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Short-course, direct-acting antivirals and ezetimibe to prevent HCV infection in recipients of organs from HCV-infected donors: a phase 3, single-centre, open-label study

Author

Feld, Jordan J, Cypel, Marcelo, Kumar, Deepali, Dahari, Harel, Pinto Ribeiro, Rafaela Vanin, Marks, Nikki, Kamkar, Nellie, Bahinskaya, Ilona, Onofrio, Fernanda Q, Zahoor, Mohamed A, Cerrochi, Orlando, Tinckam, Kathryn, Kim, S Joseph, Schiff, Jeffrey, Reichman, Trevor W, McDonald, Michael, Alba, Carolina, Waddell, Thomas K, Sapisochin, Gonzalo, Selzner, Markus, Keshavjee, Shaf, Janssen, Harry L A, Hansen, Bettina E, Singer, Lianne G, and Humar, Atul

Published
2020
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13. Ultra-short duration direct acting antiviral prophylaxis to prevent virus transmission from hepatitis C viremic donors to hepatitis C negative kidney transplant recipients

Author

Gupta, Gaurav, Yakubu, Idris, Bhati, Chandra S., Zhang, Yiran, Kang, Le, Patterson, Julie A., Andrews-Joseph, Ayana, Alam, Anam, Ferreira-Gonzalez, Andrea, Kumar, Dhiren, Moinuddin, Irfan K., Kamal, Layla, King, Anne L., Levy, Marlon, Sharma, Amit, Cotterell, Adrian, Reichman, Trevor W., Khan, Aamir, Kimball, Pamela, Stiltner, Rodney, Baldecchi, Mary, Brigle, Nathaniel, Gehr, Todd, and Sterling, Richard K.

Published
2020
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19. Pancreas transplantation with grafts obtained from donation after cardiac death or donation after brain death results in comparable outcomes

Author

Bleszynski, Michael S., primary, Parmentier, Catherine, additional, Torres-Hernandez, Alejandro, additional, Ray, Samrat, additional, Yousuf, Anila, additional, Norgate, Andrea, additional, Schiff, Jeffrey, additional, Shwaartz, Chaya, additional, Sapisochin, Gonzalo, additional, McGilvray, Ian, additional, Selzner, Markus, additional, and Reichman, Trevor W., additional

Published
2023
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20. Thromboprophylaxis With Heparin During Orthotopic Liver Transplantation: Comparison of Hepcon HMS Plus and Anti-Xa Assays for Low-Range Heparin

Author

Nicolau-Raducu, Ramona, Occhipinti, Elise, Marshall, Thomas, Koveleskie, Joseph, Ganier, Donald, Evans, Brian, Daly, William, Fish, Brian, Cohen, Ari J., Reichman, Trevor W., Bruce, David, Bohorquez, Humberto, Seal, John, Ahmed, Emily, Carmody, Ian, Loss, George, Rayburn, Jonathan, and Nossaman, Bobby

Published
2017
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24. European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Author

Ferrer-Fàbrega, Joana, primary, Mesnard, Benoît, additional, Messner, Franka, additional, Doppenberg, Jason B., additional, Drachenberg, Cinthia, additional, Engelse, Marten A., additional, Johnson, Paul R. V., additional, Leuvenink, Henri G. D., additional, Oniscu, Gabriel C., additional, Papalois, Vassilios, additional, Ploeg, Rutger J., additional, Reichman, Trevor W., additional, Scott, William E, additional, Vistoli, Fabio, additional, Berney, Thierry, additional, Jacobs-Tulleneers-Thevissen, Daniel, additional, Kessaris, Nicos, additional, Weissenbacher, Annemarie, additional, Ogbemudia, Ann Etohan, additional, White, Steve, additional, and Branchereau, Julien, additional

Published
2023
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37. When is the optimal time to discharge patients after liver transplantation with respect to short‐term outcomes? A systematic review of the literature and expert panel recommendations.

Author

Tanaka, Tomohiro, Reichman, Trevor W., Olmos, Andrea, Akamatsu, Nobuhisa, Mrzljak, Anna, Spiro, Michael, Raptis, Dimitri Aristotle, and Berlakovich, Gabriela

Subjects
*LIVER transplantation, *HOSPITAL admission & discharge, *LENGTH of stay in hospitals, *GRAFT survival, *HEPATIC veno-occlusive disease
Abstract

Background: Several factors associated with prolonged hospital stay have been described. A recent study demonstrated that hospital length of stay (LOS) is directly associated with an increased cost for liver transplantation (LT) and may be associated with greater mortality; however, the factors associated with post‐LT mortality are also related to a prolonged hospital stay, that is, those factors are confounders. Thus, the actual impact of the length of post‐LT hospital stay on both short‐term and long‐term patient and graft survival remains uncertain. Objectives: To identify the optimal time to discharge patients after LT with respect to short‐term outcomes; readmission rate, 30–90‐mortality and morbidity. Methods: Systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. Initial search keywords for screening were as follows; ((discharge AND (time OR "time point" OR "time‐point")) OR "length of hospital stay" OR "length of stay") AND ((liver OR hepatic) AND (transplant OR transplantation)). PROSPERO ID: CRD42021245598 Results: The strength of recommendation was rated as Weak, and we did not identify the direction of recommendations regarding the optimal timing after LT concerning short‐term outcomes, including "Readmission rate," six studies on 30‐ and/or 90‐day mortality, and five studies on "30‐ and/or 90‐day morbidity rate." Conclusions: Evidence is scarce to judge the optimal timing to discharge patients after LT with respect to short‐term outcomes. In centers with robust outpatient follow‐up, discharge can occur safely as early as post‐transplant 6–8 days (Quality of Evidence [QOE]; Low | Grade of Recommendation; Weak). [ABSTRACT FROM AUTHOR]

Published
2022
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45. Contributors

Author

Abrams, John M., primary, Adelman, John P., additional, Alcorn, Joseph L., additional, Alessi, Dario R., additional, Alexov, Emil, additional, Alford, Simon, additional, Alitalo, Kari, additional, Allison, James P., additional, Almo, Steven C., additional, Alory, Christelle, additional, Al-Shamkhani, Aymen, additional, Amundson, Sally A., additional, Anderson, Carl W., additional, Andersen, Jannik N., additional, Angel, Peter, additional, Appella, Ettore, additional, Arendshorst, William J., additional, Arkinstall, Steve, additional, Audhya, Anjon, additional, Avruch, Joseph, additional, Bader, Gary D., additional, Bagala, Cinzia, additional, Balch, William E., additional, Balsinde, Jesus, additional, Banerjee, Utpal, additional, Barford, David, additional, Bar-Sagi, Dafna, additional, Bartlett, Perry F., additional, Bastiaens, Philippe I.H., additional, Battelli, Chiara, additional, Baudhuin, Linnea M., additional, Beavil, Andrew J., additional, Beavil, Rebecca L., additional, Beavo, Joseph A., additional, Bello-Reuss, Elsa, additional, Bellum, Stephen, additional, Belmonte, Juan Carlos Izpisúa, additional, Bennett, Craig B., additional, Benovic, Jeffrey L., additional, Berridge, Michael J., additional, Beuning, Penny J., additional, Bhandari, Rashna, additional, Bhattacharya, Ananya, additional, Biel, Martin, additional, Bielinski, Vincent A., additional, Bilak, Hana, additional, Birnbaumer, Lutz, additional, Birrell, Geoff, additional, Bishop, Gail A., additional, Blackmer, Trillium, additional, Blackshear, Perry J., additional, Blattner, Christine, additional, Blaustein, Mordecai P., additional, Bokoch, Gary M., additional, Bonewald, Lynda F., additional, Bonomi, Marco, additional, Booden, Michelle A., additional, Boone, Charles, additional, Bootman, Martin D., additional, Bos, Johannes L., additional, Bradbury, Jane M., additional, Bradshaw, Ralph A., additional, Bresnick, Anne R., additional, Brevnova, Lena, additional, Brinkworth, Ross I., additional, Brown, Michael S., additional, Brown, Steven A., additional, Brunet, Anne, additional, Bucki, Robert, additional, Burgoyne, Robert D., additional, Buss, Janice E., additional, Butow, Ronald A., additional, Capdevila, Javier, additional, Carafoli, Ernesto, additional, Carlson, Cathrine R., additional, Carpenter, Graham, additional, Carrillo, Juan J., additional, Casey, Patrick J., additional, Catterall, William A., additional, Cerione, Richard A., additional, Cesareni, Gianni, additional, Chan, Andrew C., additional, Chang, Geoffrey, additional, Chao, Moses V., additional, Charbonneau, Harry, additional, Chen, Philip, additional, Cheng, Alan, additional, Chiu, Chris, additional, Chow, Dar-chone, additional, Chrisman, Ted D., additional, Christensen, Anne Elisabeth, additional, Chung, Jee Y., additional, Churchill, Grant C., additional, Ciechanover, Aaron, additional, Cingolani, Gino, additional, Claeysen, Sylvie, additional, Closset, Jean, additional, Cockcroft, Shamshad, additional, Cohen, Patricia T.W., additional, Cohen, Philip, additional, Colbran, Roger J., additional, Comstock, Clay E.S., additional, Conti, Marco, additional, Corbin, Jackie D., additional, Corda, Daniela, additional, Costagliola, Sabine, additional, Cote, Rick H., additional, Coughlin, Shaun R., additional, Cowart, L. Ashley, additional, Cox, Adrienne D., additional, Cragg, Mark S., additional, Crespo, José L., additional, Crosio, Claudia, additional, Daly, Christopher, additional, Damak, Sami, additional, Dasso, Mary, additional, David, Michael, additional, Davis, Anthony J., additional, Davis, Roger J., additional, Day, Richard N., additional, Degerman, Eva, additional, DeLano, Warren L., additional, Dell'Acqua, Mark L., additional, Délot, Emmanuèle, additional, Demple, Bruce, additional, Dennis, Edward A., additional, Denu, John M., additional, DePaoli-Roach, Anna A., additional, Der, Channing J., additional, de Rooij, Johan, additional, de Sauvage, Frederic, additional, Devreotes, Peter N., additional, Dewaste, Valérie, additional, Dickson, Robert B., additional, Diebold, Becky A., additional, Fiori, Pier Paolo Di, additional, Girolamo, Maria Di, additional, Diplexcito, Julie, additional, Dixon, Jack E., additional, Doms, Robert W., additional, Donoghue, Daniel J., additional, Doolittle, Russell F., additional, Døskeland, Stein Ove, additional, Dostmann, Wolfgang R.G., additional, Dreyer, Matthias K., additional, Du, Guo Guang, additional, Du, Keyong, additional, Duchen, Michael R., additional, Dunphy, William G., additional, Durgan, Joanne, additional, Dustin, Michael L., additional, Edwards, Peter A., additional, Egen, Jackson G., additional, Eiden, Lee E., additional, Elion, Elaine A., additional, Emr, Scott, additional, Engelhardt, Othmar G., additional, Erneux, Christophe, additional, Espenshade, Peter J., additional, Esplin, Edward D., additional, Evers, B. Mark, additional, Eyles, Joanne L., additional, Fame, Sheelagh, additional, Farquhar, Marilyn, additional, Feil, Robert, additional, Feng, Gui-Jie, additional, Fields, Stanley, additional, Fiordalisi, James J., additional, Firtel, Richard A., additional, Fitzgerald, Garret A., additional, Flint, Andrew, additional, Foiani, Marco, additional, Forman, Barry Marc, additional, Fornace, Albert J., additional, Francis, Sharron H., additional, Fritz, Günter, additional, Fruman, David A., additional, Galione, Antony, additional, Gandhi, Chris S., additional, Garbers, David L., additional, Garcia, K. Christopher, additional, Geiger, Benjamin, additional, Gerace, Larry, additional, Gerstner, Andrea, additional, Giaccia, Amato J., additional, Giannattasio, Michele, additional, Giguère, Vincent, additional, Glass, Christopher K., additional, Glennie, Martin J., additional, Glick, Jennifer L., additional, Goldstein, Joseph L., additional, Gopal, Venkatesh, additional, Gorospe, Myriam, additional, Govaerts, Cedric, additional, Graves, Paul R., additional, Gray, Patrick W., additional, Graziani, Irene, additional, Green, Douglas R., additional, Greenberg, Michael E., additional, Greenwald, Iva, additional, Gu, Haihua, additional, Gueven, Nuri, additional, Gutkind, J. Silvio, additional, Haeggström, Jesper Z., additional, Hall, Alan, additional, Hall, Michael N., additional, Haller, Otto, additional, Hamm, Heidi E., additional, Hannun, Yusef A., additional, Hansen, Carl A., additional, Harden, T. Kendall, additional, Hardie, D. Grahame, additional, Hasegawa, Kiminori, additional, Hawkins, Phillip T., additional, Haystead, Timothy A.J., additional, He, Xiao-lin, additional, Heizmann, Claus W., additional, Heldin, Carl-Henrik, additional, Hermiston, Michelle L., additional, Herrlich, Peter, additional, Hewat, Elizabeth A., additional, Hille, Bertil, additional, Hilton, Douglas J., additional, Hinchliffe, K.A., additional, Ho, Steffan N., additional, Ho, Su-Chin, additional, Hochstrasser, Mark, additional, Hofmann, Franz, additional, Hogue, Christopher W., additional, Hol, Wim G.J., additional, Holash, Jocelyn, additional, Holmgren, Robert A., additional, Honig, Barry, additional, Hostager, Bruce S., additional, Hubbard, Stevan R., additional, Huber, Michael, additional, Hunter, Tony, additional, Huttenlocher, Anna, additional, Hymowitz, Sarah G., additional, Ihle, James N., additional, Imler, Jean-Luc, additional, Irvine, R.F., additional, Isacoff, Ehud Y., additional, Iturrioz, Xavier, additional, Iversen, Lars F., additional, Iyengar, Ravi, additional, Jackson, Stephen P., additional, Jan, Lily Yeh, additional, Janiak-Spens, Fabiola, additional, Janmey, Paul A., additional, Jansen, Peter Gildsig, additional, Jarriault, Sophie, additional, Javitch, Jonathan A., additional, Jensen, Elwood V., additional, Jepsen, Kristen, additional, Jones, E. Yvonne, additional, Jones, Katherine A., additional, Jordan, J. Dedrick, additional, Joseph, Jomon, additional, Justement, Louis B., additional, Kafri, Yariv, additional, Kahn, Richard A., additional, Kang, Shin W., additional, Karlin, Arthur, additional, Kast-Woelbern, Heidi R., additional, Kaufman, Randal J., additional, Kazlauskas, Andrius, additional, Keen, James H., additional, Kemler, Rolf, additional, Kemp, Bruce E., additional, Kennedy, Mary B., additional, Kennedy, Matthew A., additional, Kikkawa, Ushio, additional, Kim, Albert H., additional, Kim, Soo-A, additional, Kim, Sung-Hou, additional, Kim, Youngjoo, additional, King-Jones, Kirst, additional, Kintner, Chris, additional, Kivimäe, Saul, additional, Klee, Claude B., additional, Klein, Rüdiger, additional, Kleppisch, Thomas, additional, Kliewer, Steven A., additional, Klinghoffer, Richard A., additional, Knoblich, Juergen A., additional, Kobe, Bostjan, additional, Kochs, George, additional, Kong-Beltran, Monica, additional, König, Rolf, additional, Koong, Albert C., additional, Korc, Murray, additional, Kornitzer, Daniel, additional, Kossiakoff, Anthony A., additional, Kotera, Jun, additional, Kovalenko, M.V., additional, Kozasa, Tohru, additional, Kozlov, Sergei, additional, Kozminski, Keith G., additional, Krugmann, Sonja, additional, Kuriyan, John, additional, Kurokawa, Riki, additional, Kwong, Peter D., additional, Lai, Wi S., additional, Lamar, Elise, additional, Lambert, Millard H., additional, Lambright, David G., additional, Lancet, Doron, additional, Landry, Reiko, additional, Langdon, Wallace Y., additional, Langeberg, Lorene K., additional, Lasko, Paul, additional, Latham, Vaughn, additional, Lavin, Martin F., additional, Lease, Kevin A., additional, Leffler, Hakon, additional, Lemmon, Mark A., additional, Leonard, Ann E., additional, Levitzki, Alexander, additional, Liao, Hong-Jun, additional, Liaw, Lucy, additional, Liberi, Giordano, additional, Lickert, Heiko, additional, Liddington, Robert C., additional, Lincoln, Thomas M., additional, Linder, Jürgen U., additional, Linder, Maurine E., additional, Liu, Hui, additional, Liu, Zhengchang, additional, Lohela, Marja K., additional, Louie, Sarah H., additional, Luttrell, Deirdre K., additional, Luttrell, Louis M., additional, Lyons, Karen M., additional, Macaulay, S. Lance, additional, Maceyka, Michael, additional, Maciag, Thomas, additional, Macian, Fernando, additional, MacKintosh, Carol, additional, MacLennan, David H., additional, Mahmood, Nadir A., additional, Malbon, Craig C., additional, Malik, Sohail, additional, Man, Orna, additional, Manahan, Carol L., additional, Mandinova, Anna, additional, Manganiello, Vincent C., additional, Manley, James L., additional, Mann, Matthias, additional, Manning, Gerald, additional, Manser, Ed, additional, Margeta-Mitrovic, Marta, additional, Margolskee, Robert F., additional, Marinissen, Julia, additional, Mariuzza, Roy A., additional, Marmor, Mina D., additional, Martin, G. Steven, additional, Martin, Karen H., additional, Martinez, Sergio E., additional, Mathews, Michael B., additional, Mayer, Bruce J., additional, Mayer, Mark L., additional, Mazzoni, Maria R., additional, McCormick, Frank, additional, McGowan, Clare H., additional, McKay, Melissa M., additional, McKeehan, Wallace L., additional, McLean, Alison J., additional, Means, Anthony R., additional, Meili, Ruedi, additional, Meng, Jingwei, additional, Merchant, Mark, additional, Mercurio, Frank, additional, Milligan, Graeme, additional, Ming, Guo-Li, additional, Minor, Daniel L., additional, Moghal, Nadeem, additional, Møller, Neils Peter H., additional, Mongillo, Marco, additional, Montminy, Marc, additional, Moon, Randall T., additional, Morimoto, Richard I., additional, Moss, Stephen E., additional, Mott, Helen R., additional, Mouta, Carla, additional, Muda, Marco, additional, Mumby, Marc C., additional, Murphy, Gretchen A., additional, Muzi-Falconi, Marco, additional, Nagaraj, Raghavendra, additional, Nahorski, Stefan R., additional, Nairn, Angus C., additional, Nash, Piers, additional, Neel, Benjamin G., additional, Newton, Alexandra C., additional, Nishizuka, Yasutomi, additional, Noel, Joseph P., additional, Nollen, Ellen A.A., additional, Nooren, Irene M.A., additional, O'Connor, Rodney, additional, Offermanns, Stefan, additional, Olender, Tsviya, additional, Ong, Shao-En, additional, Owen, Darerca, additional, Pagliari, Lisa J., additional, Pao, Lily, additional, Papaconstantinou, John, additional, Pardo, Leonardo, additional, Park, Hay-Oak, additional, Park, Young Chul, additional, Parker, Peter J., additional, Parsons, J. Thomas, additional, Passner, J.M., additional, Pawson, Tony, additional, Pelliccioli, Achille, additional, Perez-Polo, J. Regino, additional, Perrimon, Norbert, additional, Petite, Fabrice G., additional, Petroulakis, Emmanuel, additional, Pfaff, Samuel L., additional, Piehler, Jacob, additional, Pike, Linda J., additional, Pinkoski, Michael J., additional, Pixley, Fiona J., additional, Plevani, Paolo, additional, Poo, Mu-ming, additional, Pozzan, Tullioi, additional, Prescott, Stephen M., additional, Prudovsky, Igor, additional, Putney, James W., additional, Radimerski, Thomas, additional, Radzio-Andzelm, Elzbieta, additional, Ram, Prahlad T., additional, Rameh, Lucia, additional, Ramljak, Danica, additional, Ranscht, Barbara, additional, Rao, Anjana, additional, Raport, Carol J., additional, Reeves, Jacqueline D., additional, Rehman, Holger, additional, Reichman, Trevor W., additional, Reiter, Eric, additional, Resnick, Michael A., additional, Reth, Michael, additional, Rhee, Sue Goo, additional, Richter, Joel D., additional, Rietze, Rodney L., additional, Rini, James M., additional, Ripperger, Jürgen A., additional, Rizo, Josep, additional, Robishaw, Janet D., additional, Roderick, H. 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Published
2003
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50. Novel Biliary Reconstruction Techniques During Liver Transplantation

Author

Carmody, Ian C., Romano, John, Bohorquez, Humberto, Bugeaud, Emily, Bruce, David S., Cohen, Ari J., Seal, John, Reichman, Trevor W., and Loss, George E.

Subjects
Focus on Transplantation
Abstract

Biliary complications remain a significant problem following liver transplantation. Several surgical options can be used to deal with a significant size mismatch between the donor and recipient bile ducts during the biliary anastomosis. We compared biliary transposition to recipient biliary ductoplasty in cadaveric liver transplant.A total of 33 reconstructions were performed from January 1, 2005 to December 31, 2013. In the biliary transposition group (n=23), 5 reconstructions were performed using an internal stent (5 or 8 French pediatric feeding tube), and 18 were performed without. Of the 10 biliary ductoplasties, 2 were performed with a stent. All patients were managed with standard immunosuppression and ursodiol. Follow-up ranged from 2 months to 5 years.No patients in the biliary transposition group required reoperation; 1 patient had an internal stent removed for recurrent unexplained leukocytosis, and 2 patients required endoscopic retrograde cholangiography and stent placement for evidence of stricture. Three anastomotic leaks occurred in the biliary ductoplasty group, and 2 patients in the biliary ductoplasty group required reoperation for biliary complications.Our results indicate that biliary reconstruction can be performed with either biliary transposition or biliary ductoplasty. These techniques are particularly useful when a significant mismatch in diameter exists between the donor and recipient bile ducts.

Published
2017

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