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3. Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations

Author

Williams, David, Lafontaine, Anne Louise, Marras, Connie, Jog, Mandar, Panisset, Michael, Lang, Anthony, Parker, Lesley, Stewart, Alistair J., Corvol, Jean-Christophe, Azulay, Jean-Philippe, Couratier, Philippe, Mollenhauer, Brit, Lorenzl, Stefan, Ludolph, Albert, Benecke, Reiner, Hoglinger, Gunter, Lipp, Axel, Reichmann, Heinz, Woitalla, Dirk, Chan, Dennis, Zermansky, Adam, Burn, David, Lees, Andrew, Gozes, Illana, Boxer, Adam, Miller, Bruce L., Lobach, Iryna V., Roberson, Erik, Honig, Lawrence, Zamrini, Edward, Pahwa, Rajesh, Bordelon, Yvette, Driver-Dunkley, Erika, Lessig, Stephanie, Lew, Mark, Womack, Kyle, Boeve, Brad, Ferrara, Joseph, Hillis, Argyle, Kaufer, Daniel, Kumar, Rajeev, Xie, Tao, Gunzler, Steven, Zesiewicz, Theresa, Dayalu, Praveen, Golbe, Lawrence, Grossman, Murray, Jankovic, Joseph, McGinnis, Scott, Santiago, Anthony, Tuite, Paul, Isaacson, Stuart, Leegwater-Kim, Julie, Litvan, Irene, Knopman, David S., Schneider, Lon S., Doody, Rachelle S., Golbe, Lawrence I., Roberson, Erik D., Koestler, Mary, Jack, Clifford R., Jr., Van Deerlin, Viviana, Randolph, Christopher, Whitaker, Steve, Hirman, Joe, Gold, Michael, Morimoto, Bruce H., Nuebling G, Georg, Hensler, Mira, Paul, Sabine, Zwergal, Andreas, Heuer, Hilary W., Tartaglia, Maria C., McGinnis, Scott M., Dickerson, Bradford C., Kornak, John, Schuff, Norbert, Rabinovici, Gil D., Rosen, Howard J., Boxer, Adam L., Gómez, J.C., Tijero, B., Berganzo, K., Garc'ıa de Yebenes, J., Lopez Sendón, J.L., Garcia, G., Tolosa, E., Buongiorno, M.T., Bargalló, N., Burguera, J.A., Martinez, I., Ruiz-Mart'ınez, J., Narrativel, I., Vivancos, F., Ybot, I., Aguilar, M., Quilez, P., Boada, M., Lafuente, A., Hernandez, I., López-Lozano, J.J., Mata, M., Kupsch, A., Lipp, A., Ebersbach, G., Schmidt, T., Hahn, K., Höglinger, G., Höllerhage, M., Oertel, W.H., Respondek, G., Stamelou, M., Reichmann, H., Wolz, M., Schneider, C., Klingelhöfer, L., Berg, D., Maetzler, W., Srulijes, K.K., Ludolph, A., Kassubek, J., Steiger, M., Tyler, K., Burn, D.J., Morris, L., Lees, A., Ling, H., Hauser, R., McClain, T., Truong, D., Jenkins, S., Litvan, I., Houghton, D., Ferrara, J., Bordelon, Y., Gratiano, A., Golbe, L., Mark, M., Uitti, R., Ven Gerpen, J., Brittain, Claire, McCarthy, Andrew, Irizarry, Michael C., McDermott, Dana, Biglan, Kevin, Höglinger, Günter U., and del Ser, Teodoro

Published
2019
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5. Contributors

Author

Abboud, Hesham, primary, Abdelkader, Noha F., additional, Abellanas, Miguel A., additional, Adams, Warwick R., additional, Airavaara, Mikko, additional, Al-Busaidi, Ibrahim S., additional, Alamri, Yassar, additional, Alberico, Stephanie L., additional, Alexiou, Athanasios, additional, Almeida, Lorena Rosa S., additional, Anderton, Ryan S., additional, Antipova, Veronica, additional, Aragona, Emanuela, additional, Arrigo, Alessandro, additional, Ashraf, Ghulam Md, additional, Auffret, Manon, additional, Aymerich, Maria S., additional, Bakeberg, Megan, additional, Barnes, Graham R., additional, Belbasis, Lazaros, additional, Bellou, Vanesa, additional, Benedetti, Fabrizio, additional, Benson, Patrick, additional, Bergantin, Leandro Bueno, additional, Bhidayasiri, Roongroj, additional, Bortolanza, Mariza, additional, Byrnes, Michelle, additional, Calamuneri, Alessandro, additional, Caricati-Neto, Afonso, additional, Carlino, Elisa, additional, Chaudhary, Sapana Sameer, additional, Chaudhary, Sameer, additional, Chmielarz, Piotr, additional, Chuproski, Ana Paula, additional, Del-Bel, Elaine, additional, De Risi, Marco, additional, Devedjian, J.C., additional, Devos, D., additional, Di Gennaro, Giancarlo, additional, Domanskyi, Andrii, additional, Dominico, Patrícia, additional, Drapier, Sophie, additional, Duce, J.A., additional, Dutta, Aloke K., additional, Eidelberg, David, additional, Evangelou, Evangelos, additional, Fagotti, Juliane, additional, Farotti, Lucia, additional, Fisichella, M., additional, Forjaz, Maria João, additional, Frisaldi, Elisa, additional, Fuermaier, Anselm B.M., additional, Fukushima, Kikuro, additional, Fukushima, Junko, additional, Gaeta, Michele, additional, Gordon, Luke, additional, Hawlitschka, Alexander, additional, Holzmann, Carsten, additional, Jansen, Josephien, additional, Januário, Cristina, additional, Jesus-Ribeiro, Joana, additional, Johnstone, Daniel M., additional, Koerts, Janneke, additional, Konovalova, Julia, additional, Kurth, Jens, additional, Lachaud, C., additional, Laloux, C., additional, Lanotte, Michele, additional, LeWitt, Peter A., additional, Lima, Marcelo M.S., additional, Lindner, Tobias, additional, Loewenbrück, K.F., additional, Lopiano, Leonardo, additional, Luo, Dan, additional, Mann, Teresa, additional, Mao, Peizhong, additional, Mao, Yifan, additional, Martinez–Martin, Pablo, additional, Mastaglia, Frank L., additional, Mizutani, Yasuaki, additional, Modugno, Nicola, additional, Moreau, C., additional, Mormina, Enricomaria, additional, Müller, Thomas, additional, Mutoh, Tatsuro, additional, Nagao, Kanae, additional, Narayanan, Nandakumar S., additional, Nascimento, Glauce Crivelaro, additional, Natesan, Saieswari, additional, Neilson, Lee, additional, Niimi, Yoshiki, additional, Olivola, Enrica, additional, Pan-Montojo, F., additional, Panhelainen, Anne, additional, Paolini Paoletti, Federico, additional, Pardeshi, Tanvee, additional, Parnetti, Lucilla, additional, Paul, Serene S., additional, Perovnik, Matej, additional, Petrucco, Claudia, additional, Piedimonte, Alessandro, additional, Rawat, Sakshi, additional, Reichmann, H., additional, Reith, Maarten, additional, Riley, Maddeson, additional, Rodríguez-Blázquez, Carmen, additional, Rožanković, Petra Bago, additional, Rus, Tomaž, additional, Sakakibara, Ryuji, additional, Santos-Lobato, Bruno L., additional, Scorza, Fúlvio Alexandre, additional, Stone, Jonathan, additional, Tang, Chris C., additional, Targa, Adriano D.S., additional, Tateno, Fuyuki, additional, Tomše, Petra, additional, Trošt, Maja, additional, Tsiang, John T.H., additional, Tucha, Lara, additional, Tucha, Oliver, additional, Uchiyama, Tomoyuki, additional, Valenca, Guilherme T., additional, Vérin, Marc, additional, Vieira, Daniela, additional, Willis, Gregory L., additional, Witt, Martin, additional, Woo, Benjamin K.P., additional, Wree, Andreas, additional, Yamamoto, Tatsuya, additional, Zande, Jonathan, additional, and Zibetti, Maurizio, additional

Published
2020
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9. High - pressure polymorphs of the ferroan dolomite: possible host structures for carbon in the lower mantle

Author

Martirosyan, N., Efthimiopoulos, I., Jahn, S., Lobanov, S., Wirth, R., Reichmann, H., and Koch-Müller, M.

Abstract

In this study, we investigated four different ferroan dolomite samples using in situ Raman spectroscopy and powder X-ray diffraction (XRD) at high pressures up to 48 GPa and at room temperature. Our results show that the transition from Dolomite-I (Dol-I) to Dolomite-II (Dol-II) occurs above 13-16 GPa, and the transition pressure depends on the composition of the solid solution. Compression above 32-35 GPa results in the appearance of the Dolomite-IIIc (Dol-IIIc) or Dolomite-IIIb (Dol-IIIb). In the high-pressure XRD study, we found that the XRD patterns of the Ca0.97(Mg0.77,Fe0.23Mn0.03)(CO3)2 (xFe = 0.23, Ank23) can be indexed as Dol-IIIc at 44 GPa, while the rhombohedral Dol-IIIb structure matches better with the XRD patterns of the xFe = 0.40 (Ank40) and 0.64 (Ank64) solid solutions. Additionally, in the Raman spectra of the Fe-richest sample (Ca0.99(Mg0.33Fe0.64Mn0.05) (CO3)2 (Ank64), we observed an abrupt frequency downshift of the CO3-stretching vibrations between 40 – 42 GPa, which may reflect a pressure-induced Fe2+ spin transition. We further investigated two samples with xFe= 0.19 (Ank19) and 0.23 (Ank23) at high pressure and high temperatures, up to at least 2600 K. The experiments revealed that the unquenchable Dol-IIIc structure could be a stable high-pressure/high-temperature polymorph in ferroan dolomite up to at least 2600 K.

Published
2023

13. Central Tremors

Author

Glöckler, T., Reichmann, H., Lajtha, Abel, editor, Youdim, Moussa B. H., editor, Riederer, Peter, editor, Mandel, Sylvia A., editor, and Battistin, Leontino, editor

Published
2007
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22. Gangstörungen

Author

Müngersdorf, Martina, Reichmann, H., König, Benno, editor, Reinhardt, Dietrich, editor, and Schuster, Hans-Peter, editor

Published
2000
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26. Progressive Neurodegeneration of the Dopaminergic system and Inhibition of the Complex I Induced by the Chloral-Derived Tetrahydro-β-Carboline TaClo

Author

Sontag, K.-H., Heim, C., Sontag, T. A., Kolasiewicz, W., Clement, W., Grote, C., Wesemann, W., Janetzky, B., Reichmann, H., Feineis, D., God, R., Bringmann, G., Rausch, D., Abdel-mohsen, M., Abdel-moneim, M., Chan, W. W., Koutsilieri, E., Zielke, B., Götz, M., Gsell, W., Riederer, P., Ohye, Chihiro, editor, Kimura, Minoru, editor, and McKenzie, John S., editor

Published
1996
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27. Das mitochondriale Genom

Author

Reichmann, H., Janetzky, B., Seibel, P., Möller, Hans-Jürgen, editor, Przuntek, Horst, editor, Laux, Gerd, editor, and Büttner, Thomas, editor

Published
1996
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31. Ophthalmoneurology

Author

Papke, K., Masur, H., Oberwittler, C., Verleger, R., Wascher, E., Kömpf, D., Mielke, R., Kessler, J., Fink, G. R., Herholz, K., Heiss, W.-D., Moser, A., Olschinka, J., Seyer, H., Fahlbusch, R., Küchle, M., Awe, B., König, H.-J., Gerding, H., Schuierer, G., Brune, G. G., Trabert, W., Grundmann, M., Drescher, S., Heide, W., Fischer, D., Fetter, M., Tweed, D., Misslisch, H., Koenig, E., Lortz, Katja, Zangemeister, W. H., Moschner, C., Rüttinger, H., Krekel, Ch., Schimrigk, K., Herbst, H., Thier, P., Dichgans, J., Scharein, Sigrid, Hartard, Christiane, Kunze, Klaus, Sievers, C., Knappertz, V., Rothacher, G., Krämer, G., Klingelhöfer, J., Wittich, I., Sander, D., Conrad, B., v. Maravic, M., Kessler, Ch., Böhning, A., Speisberg, B., Carvajal-Lizano, M., Thie, A., Schmitt, T., Erbguth, F., Taghavy, A., Reichmann, H., Gold, R., Beck, A., Maas, J., Seibel, P., Naumann, M., Schubert, M., Zierz, S., Elek, J., Dengler, R., Breul, Petra, Zierz, Stephan, Jerusalem, Felix, Schneider, Ch., Lindner, A., Klopstock, Th., Toyka, K.-V., Hansen, H. C., Lueck, C. J., Kennard, C., Krieg, P., Jost, W., Richter, J., Loew, S., Mielke, U., Ruprecht, K. W., Remberger, K., and Schimrigk, K.

Published
1992
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37. Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease

Author

Schaffernicht, G., Shang, Q., Stievenard, A., Bötzel, K., Dening, Y., Kempe, R., Toussaint, M., Gündel, D., Kranz, M., Reichmann, H., Vanbesien-Mailliot, C., Brust, P., Dieterich, M., Funk, R. H. W., Ravens, U., Pan-Montojo, F., Schaffernicht, G., Shang, Q., Stievenard, A., Bötzel, K., Dening, Y., Kempe, R., Toussaint, M., Gündel, D., Kranz, M., Reichmann, H., Vanbesien-Mailliot, C., Brust, P., Dieterich, M., Funk, R. H. W., Ravens, U., and Pan-Montojo, F.

Abstract

Parkinson's disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-motor symptoms observed in PD patients like constipation, that can precede the appearance of motor symptoms by years. Here we analyzed the effect of the pesticide rotenone, a mitochondrial Complex I inhibitor, on the function and neuronal composition of the ENS by measuring intestinal contractility in a tissue bath and by analyzing related protein expression. Our results show that rotenone changes the normal physiological response of the intestine to carbachol, dopamine and electric field stimulation (EFS). Changes in the reaction to EFS seem to be related to the reduction in the cholinergic input but also related to the noradrenergic input, as suggested by the non-adrenergic non-cholinergic (NANC) reaction to the EFS in rotenone-exposed mice. The magnitude and direction of these alterations varies between intestinal regions and exposure times and is associated with an early up-regulation of dopaminergic, cholinergic and adrenergic receptors and an irregular reduction in the amount of enteric neurons in rotenone-exposed mice. The early appearance of these alterations, that start occurring before the substantia nigra is affected in this mouse model, suggests that these alterations could be also observed in patients before the onset of motor symptoms and makes them ideal potential candidates to be used as radiological markers for the detection of Parkinson's disease in its early stages.

Published
2021

38. Increased risk of acute stroke among patients with severe COVID-19: a multicenter study and meta-analysis

Author

Siepmann, T; https://orcid.org/0000-0003-2196-5904, Sedghi, A, Simon, E, Winzer, S, Barlinn, J, de With, K, Mirow, L, Wolz, M, Gruenewald, T, Schroettner, P, von Bonin, S, Pallesen, L-P, Rosengarten, B, Schubert, J, Lohmann, T, Machetanz, J, Spieth, P, Koch, T, Bornstein, S, Reichmann, H, Puetz, V, Barlinn, K, Siepmann, T; https://orcid.org/0000-0003-2196-5904, Sedghi, A, Simon, E, Winzer, S, Barlinn, J, de With, K, Mirow, L, Wolz, M, Gruenewald, T, Schroettner, P, von Bonin, S, Pallesen, L-P, Rosengarten, B, Schubert, J, Lohmann, T, Machetanz, J, Spieth, P, Koch, T, Bornstein, S, Reichmann, H, Puetz, V, and Barlinn, K

Abstract

BACKGROUND AND PURPOSE Recent observations linked coronavirus disease 2019 (COVID-19) to thromboembolic complications possibly mediated by increased blood coagulability and inflammatory endothelial impairment. We aimed to define the risk of acute stroke in patients with severe and non-severe COVID-19. METHODS We performed an observational, multicenter cohort study in four participating hospitals in Saxony, Germany to characterize consecutive patients with laboratory-confirmed COVID-19 who experienced acute stroke during hospitalization. Furthermore, we conducted a systematic review using PubMed/MEDLINE, Embase, Cochrane Library and bibliographies of identified papers following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines including data from observational studies of acute stroke in COVID-19 patients. Data were extracted by two independent reviewers and pooled with multicenter data to calculate risk ratios (RRs) and 95% confidence intervals (95% CIs) for acute stroke related to COVID-19 severity using a random-effects model. Between-study heterogeneity was assessed using Cochran's Q and I$^{2}$ statistics. International Prospective Register of Systematic Reviews registration number: CRD42020187194. RESULTS Of 165 patients hospitalized for COVID-19 (49.1% males, median age = 67 years [57-79 years], 72.1% severe or critical) included in the multicenter study, overall stroke rate was 4.2% (95% CI: 1.9-8.7). Systematic literature search identified two observational studies involving 576 patients that were eligible for meta-analysis. Amongst 741 pooled COVID-19 patients, overall stroke rate was 2.9% (95% CI: 1.9-4.5). Risk of acute stroke was increased for patients with severe compared to non-severe COVID-19 (RR = 4.18, 95% CI: 1.7-10.25; P = 0.002) with no evidence of heterogeneity (I$^{2}$ = 0%, P = 0.82). CONCLUSIONS Synthesized analysis of data from our multicenter study and previously published cohorts indicates that severity of COVID

Published
2021

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