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2. Synchrotron Angiography General Considerations

Author

Dix, W.-R., Engelke, K., Graeff, W., Heuer, J., Kupper, W., Lohmann, M., Reime, B., Reumann, R., Wissler, Robert W., editor, Bond, M. Gene, editor, Mercuri, Michele, editor, Tanganelli, Piero, editor, Weber, Giorgio, editor, and Friedman, Gertrud, editor

Published
1991
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17. Crystal Structure of Bovine Enterovirus 2 determined with Serial Femtosecond X-ray Crystallography

Author

Roedig, P., primary, Ginn, H.M., additional, Pakendorf, T., additional, Sutton, G., additional, Harlos, K., additional, Walter, T.S., additional, Meyer, J., additional, Fischer, P., additional, Duman, R., additional, Vartiainen, I., additional, Reime, B., additional, Warmer, M., additional, Brewster, A.S., additional, Young, I.D., additional, Michels-Clark, T., additional, Sauter, N.K., additional, Kotecha, A., additional, Kelly, J., additional, Rowlands, D.J., additional, Sikorsky, M., additional, Nelson, S., additional, Damiani, D.S., additional, Alonso-Mori, R., additional, Ren, J., additional, Fry, E.E., additional, David, C., additional, Stuart, D.I., additional, Wagner, A., additional, and Meents, A., additional

Published
2017
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19. High-speed fixed-target serial virus crystallography

Author

Roedig, P., primary, Ginn, H.M., additional, Pakendorf, T., additional, Sutton, G., additional, Harlos, K., additional, Walter, T.S., additional, Meyer, J., additional, Fischer, P., additional, Duman, R., additional, Vartiainen, I., additional, Reime, B., additional, Warmer, M., additional, Brewster, A.S., additional, Young, I.D., additional, Michels-Clark, T., additional, Sauter, N.K., additional, Sikorsky, M., additional, Nelson, S., additional, Damiani, D.S., additional, Alonso-Mori, R., additional, Ren, J., additional, Fry, E.E., additional, David, C., additional, Stuart, D.I., additional, Wagner, A., additional, and Meents, A., additional

Published
2017
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20. Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging

Author

Wagner, A, Sachse, A, Keller, M, Aurich, M, Wetzel, W, Hortschansky, P, Schmuck, K, Lohmann, M, Reime, B, Metge, J, Arfelli, F, Menk, R, Rigon, L, Muehleman, C, Bravin, A, Coan, P, Mollenhauer, J, Wagner A, Sachse A, Keller M, Aurich M, Wetzel WD, Hortschansky P, Schmuck K, Lohmann M, Reime B, Metge J, Arfelli F, Menk R, Rigon L, Muehleman C, Bravin A, Coan P, Mollenhauer J, Wagner, A, Sachse, A, Keller, M, Aurich, M, Wetzel, W, Hortschansky, P, Schmuck, K, Lohmann, M, Reime, B, Metge, J, Arfelli, F, Menk, R, Rigon, L, Muehleman, C, Bravin, A, Coan, P, Mollenhauer, J, Wagner A, Sachse A, Keller M, Aurich M, Wetzel WD, Hortschansky P, Schmuck K, Lohmann M, Reime B, Metge J, Arfelli F, Menk R, Rigon L, Muehleman C, Bravin A, Coan P, and Mollenhauer J

Abstract

Diffraction enhanced imaging (DEI) uses refraction of x-rays at edges, which allows pronounced visualization of material borders and rejects scattering which often obscures edges and blurs images. Here, the first evidence is presented that, using DEI, a destruction-free evaluation of the quality of integration of metal implants into bone is possible. Experiments were performed in rabbits and sheep with model implants to investigate the option for DEI as a tool in implant research. The results obtained from DEI were compared to conventional histology obtained from the specimens. DE images allow the identification of the quality of ingrowth of bone into the hydroxyapatite layer of the implant. Incomplete integration of the implant with a remaining gap of less than 0.3 mm caused the presence of a highly refractive edge at the implant/bone border. In contrast, implants with bone fully grown onto the surface did not display a refractive signal. Therefore, the refractive signal could be utilized to diagnose implant healing and/or loosening.

Published
2006

21. Chance and limit of imaging of articular cartilage in vitro in healthy and arthritic joints - DEI (Diffraction Enhanced Imaging) in comparison with MRI, CT and ultrasound

Author

Wagner, A, Aurich, M, Stoessel, M, Sieber, N, Wetzel, W, Mollenhauer, J, Schmuck, K, Muehleman, C, Lohmann, M, Reime, B, Metge, J, Coan, P, Bravin, A, Arfelli, F, Rigon, L, Menk, R, Wagner A, Aurich M, Stoessel M, Sieber N, Wetzel WD, Mollenhauer J, Schmuck K, Muehleman C, Lohmann M, Reime B, Metge J, Coan P, Bravin A, Arfelli F, Rigon L, Menk R-H, Wagner, A, Aurich, M, Stoessel, M, Sieber, N, Wetzel, W, Mollenhauer, J, Schmuck, K, Muehleman, C, Lohmann, M, Reime, B, Metge, J, Coan, P, Bravin, A, Arfelli, F, Rigon, L, Menk, R, Wagner A, Aurich M, Stoessel M, Sieber N, Wetzel WD, Mollenhauer J, Schmuck K, Muehleman C, Lohmann M, Reime B, Metge J, Coan P, Bravin A, Arfelli F, Rigon L, and Menk R-H

Abstract

Description of purpose: Treatment of osteoarthritis in stages of reversible disease requires high resolution visualization of early cartilage damage and of subchondral bone. Here, DEI (Diffraction Enhanced Imaging) is compared to MRI, computed X-ray tomography (CT) and ultrasound (UI) in its ability to detect early degeneration of articular cartilage. In contrast to conventional absorptive X-ray examination where cartilage is poorly visible DEI captures cartilage by detection of selected refraction. Methods: Human femoral heads were investigated by macroscopic inspection, conventional X-ray examination, DEI, MRI, CT, UI and histology. DEI is an imaging technique applying a monochromatic parallel synchrotron X-ray beam. Image features were verified by histology. Results: DEI, MRI and ultrasound lead to interpretable images of cartilage. Of all techniques, DEI provided highest image resolution revealing the structural tissue architecture. MRI needs a very long exposure time (more than 5 hours) to achieve comparable quality. Application of ultrasound is limited because of joint geometry and, at high sound frequency, the necessity of close contact between cartilage and transducer. DEI is an experimental technique which needs synchrotron radiation. Conclusion: DEI is a very promising imaging technique for visualization of cartilage and bone. It may serve as an excellent analytical tool for experimental studies. Our pictures show a part of future of optimised techniques for imaging. Synchrotron based DEI may lead the way towards optimisation of improved techniques for imaging. Upon development of adequate small scale X-ray sources, DEI will also be an important supplementation for medical imaging.

Published
2005

22. Options and limitations of joint cartilage imaging: DEI in comparison to MRI and sonography

Author

Wagner, A, Aurich, M, Sieber, N, Stoessel, M, Wetzel, W, Schmuck, K, Lohmann, M, Reime, B, Metge, J, Coan, P, Bravin, A, Arfelli, F, Rigon, L, Menk, R, Heitner, G, Irving, T, Zhong, Z, Muehleman, C, Mollenhauer, J, Wagner A, Aurich M, Sieber N, Stoessel M, Wetzel WD, Schmuck K, Lohmann M, Reime B, Metge J, Coan P, Bravin A, Arfelli F, Rigon L, Menk RH, Heitner G, Irving T, Zhong Z, Muehleman C, Mollenhauer JA, Wagner, A, Aurich, M, Sieber, N, Stoessel, M, Wetzel, W, Schmuck, K, Lohmann, M, Reime, B, Metge, J, Coan, P, Bravin, A, Arfelli, F, Rigon, L, Menk, R, Heitner, G, Irving, T, Zhong, Z, Muehleman, C, Mollenhauer, J, Wagner A, Aurich M, Sieber N, Stoessel M, Wetzel WD, Schmuck K, Lohmann M, Reime B, Metge J, Coan P, Bravin A, Arfelli F, Rigon L, Menk RH, Heitner G, Irving T, Zhong Z, Muehleman C, and Mollenhauer JA

Abstract

Diffraction Enhanced Imaging (DEI) is an X-ray imaging method to provide additional contrast and diminish untoward image signals by reducing scattering. Previous reports demonstrated its applicability in soft and hard tissue imaging. Here we provide further evidence for the improved overall image quality and for the option to discriminate various tissue-specific properties, such as collagen fiber elements or mineralization. Comparative ex vivo data to medical MRI and to medical ultrasound are shown, utilizing human ankle and hip specimens.

Published
2005

26. The concept of spatial frequency depending dqe and its application to a comparison of two detectors used in transvenous coronary angiography

Author

MENK R. H, THOMLINSON W, GMU, R. N, ZHONG Z, CHAPMAN D, DIX W. R, GRAEFF W, LOHMANN M, ILLING G, SCHILDWA, CHTER L, REIME B, KUPPER W, HAMM C, GIACOMINI J. C, GORDON H. J, RUBENSTEIN E, DERVAN J, BESCH H. J, WALENTA A. H., ARFELLI, FULVIA, MENK R., H, Thomlinson, W, Gmu, R. N, Zhong, Z, Chapman, D, Arfelli, Fulvia, DIX W., R, Graeff, W, Lohmann, M, Illing, G, Schildwa, Chter, L, Reime, B, Kupper, W, Hamm, C, GIACOMINI J., C, GORDON H., J, Rubenstein, E, Dervan, J, BESCH H., J, and Walenta, A. H.

Published
1997

32. Coherent imaging of biological samples with femtosecond pulses at the free-electron laser FLASH

Author

Mancuso, A P, primary, Gorniak, Th, additional, Staier, F, additional, Yefanov, O M, additional, Barth, R, additional, Christophis, C, additional, Reime, B, additional, Gulden, J, additional, Singer, A, additional, Pettit, M E, additional, Nisius, Th, additional, Wilhein, Th, additional, Gutt, C, additional, Grübel, G, additional, Guerassimova, N, additional, Treusch, R, additional, Feldhaus, J, additional, Eisebitt, S, additional, Weckert, E, additional, Grunze, M, additional, Rosenhahn, A, additional, and Vartanyants, I A, additional

Published
2010
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33. X-ray polarimetry using the photoeffect in a CCD-detector

Author

Buschhorn, G W, Kotthaus, R, Kufner, W, Rössl, W, Rzepka, M, Schmidt, K H, Genz, H, Gräf, H D, Hoffmann-Stascheck, P, Nething, U, Richter, A, Dix, W R, Illing, G, Lohmann, M, Reime, B, and Schildwächter, L

Subjects
Accelerators and Storage Rings
Published
1993

34. Resonant magnetic scattering with soft x-ray pulses from a free-electron laser operating at 1.59 nm

Author

Gutt, C., primary, Stadler, L.-M., additional, Streit-Nierobisch, S., additional, Mancuso, A. P., additional, Schropp, A., additional, Pfau, B., additional, Günther, C. M., additional, Könnecke, R., additional, Gulden, J., additional, Reime, B., additional, Feldhaus, J., additional, Weckert, E., additional, Vartanyants, I. A., additional, Hellwig, O., additional, Staier, F., additional, Barth, R., additional, Grunze, M., additional, Rosenhahn, A., additional, Stickler, D., additional, Stillrich, H., additional, Frömter, R., additional, Oepen, H. P., additional, Martins, M., additional, Nisius, T., additional, Wilhein, T., additional, Faatz, B., additional, Guerassimova, N., additional, Honkavaara, K., additional, Kocharyan, V., additional, Treusch, R., additional, Saldin, E., additional, Schreiber, S., additional, Schneidmiller, E. A., additional, Yurkov, M. V., additional, Eisebitt, S., additional, and Grübel, G., additional

Published
2009
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35. Coherent-Pulse 2D Crystallography Using a Free-Electron Laser X-Ray Source

Author

Mancuso, A. P., primary, Schropp, A., additional, Reime, B., additional, Stadler, L.-M., additional, Singer, A., additional, Gulden, J., additional, Streit-Nierobisch, S., additional, Gutt, C., additional, Grübel, G., additional, Feldhaus, J., additional, Staier, F., additional, Barth, R., additional, Rosenhahn, A., additional, Grunze, M., additional, Nisius, T., additional, Wilhein, T., additional, Stickler, D., additional, Stillrich, H., additional, Frömter, R., additional, Oepen, H.-P., additional, Martins, M., additional, Pfau, B., additional, Günther, C. M., additional, Könnecke, R., additional, Eisebitt, S., additional, Faatz, B., additional, Guerassimova, N., additional, Honkavaara, K., additional, Kocharyan, V., additional, Treusch, R., additional, Saldin, E., additional, Schreiber, S., additional, Schneidmiller, E. A., additional, Yurkov, M. V., additional, Weckert, E., additional, and Vartanyants, I. A., additional

Published
2009
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41. Instrumentation For Diffraction Enhanced Imaging Experiments At HASYLAB.

Author

Lohmann, M., Dix, W.-R., Metge, J., Reime, B., and Warwick, T.

Subjects
X-ray diffraction, RADIOGRAPHY, MEDICAL imaging systems, REFRACTION (Optics), MONOCHROMATORS, STORAGE rings
Abstract

The new X-ray radiography imaging technique, named diffraction enhanced imaging (DEI), enables almost scatter free absorption imaging, the production of the so-called refraction images of a sample. The images show improved contrast compared to standard imaging applications. At the HASYLAB wiggler beamline W2 at the 2nd-generation storage ring DORIS a 5cm wide beam with an adjustable energy between 10 and 70keV is available. A Si [111] pre-monochromator is used followed by the main monochromator using the (111) or the (333)-reflection. Visualization of fossils, detecting internal pearl structures, monitoring of bone and cartilage and documentation of implant healing in bone are application examples at HASYLAB. © 2004 American Institute of Physics [ABSTRACT FROM AUTHOR]

Published
2004
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45. The concept of spatial frequency depending DQE and its application to a comparison of two detectors used in transvenous coronary angiography

Author

Menk, R.H., primary, Thomlinson, W., additional, Gmür, N., additional, Zhong, Z., additional, Chapman, D., additional, Arfelli, F., additional, Dix, W.R., additional, Graeff, W., additional, Lohmann, M., additional, Illing, G., additional, Schildwächter, L., additional, Reime, B., additional, Kupper, W., additional, Hamm, C., additional, Giacomini, J.C., additional, Gordon, H.J., additional, Rubenstein, E., additional, Dervan, J., additional, Besch, H.J., additional, and Walenta, A.H., additional

Published
1997
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46. Intravenous coronary angiography with synchrotron radiation

Author

Dix, W-R, primary, Besch, H J, additional, Graeff, W, additional, Hamm, C W, additional, Illing, G, additional, Kupper, W, additional, Lohmann, M, additional, Meinertz, T, additional, Menk, R H, additional, Reime, B, additional, Rust, C, additional, Schildwächter, L, additional, and Walenta, A H, additional

Published
1996
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47. A dual line multicell ionization chamber for transvenous coronary angiography with synchrotron radiation

Author

Menk, R. H., primary, Dix, W.‐R., additional, Graeff, W., additional, Illing, G., additional, Reime, B., additional, Schildwächter, L., additional, Tafelmeier, U., additional, Besch, H. J., additional, Grossmann, U., additional, Langer, R., additional, Lohmann, M., additional, Schenk, H. W., additional, Wagener, M., additional, Walenta, A. H., additional, Kupper, W., additional, Hamm, C., additional, and Rust, C., additional

Published
1995
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49. Coronary angiography with synchrotron radiation

Author

Dix, W.-R., primary, Besch, H. J., additional, Graeff, W., additional, Hamm, C. W., additional, Illing, G., additional, Kupper, W., additional, Lohmann, M., additional, Meinertz, T., additional, Menk, R. H., additional, Reime, B., additional, Rust, C., additional, Schildwächter, L., additional, Tafelmeier, U., additional, and Walenta, A. H., additional

Published
1994
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50. X-ray polarimetry using the photoeffect in a CCD detector

Author

Buschhorn, G., primary, Kotthaus, R., additional, Kufner, W., additional, Rössl, W., additional, Rzepka, M., additional, Schmidt, K.H., additional, Genz, H., additional, Gräf, H.-D., additional, Hoffmann-Stascheck, P., additional, Nething, U., additional, Richter, A., additional, Dix, W.-R., additional, Illing, G., additional, Lohmann, M., additional, Pflüger, J., additional, Reime, B., additional, and Schildwächter, L., additional

Published
1994
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