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539 results on '"Reina C"'

1. Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19

Author

Nickols, Nicholas G, Mi, Zhibao, DeMatt, Ellen, Biswas, Kousick, Clise, Christina E, Huggins, John T, Maraka, Spyridoula, Ambrogini, Elena, Mirsaeidi, Mehdi S, Levin, Ellis R, Becker, Daniel J, Makarov, Danil V, Adorno Febles, Victor, Belligund, Pooja M, Al-Ajam, Mohammad, Muthiah, Muthiah P, Montgomery, Robert B, Robinson, Kyle W, Wong, Yu-Ning, Bedimo, Roger J, Villareal, Reina C, Aguayo, Samuel M, Schoen, Martin W, Goetz, Matthew B, Graber, Christopher J, Bhattacharya, Debika, Soo Hoo, Guy, Orshansky, Greg, Norman, Leslie E, Tran, Samantha, Ghayouri, Leila, Tsai, Sonny, Geelhoed, Michelle, and Rettig, Mathew B

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Lung, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Respiratory, Good Health and Well Being, Aged, Aged, 80 and over, Androgens, COVID-19, Hospitalization, Humans, Hypertension, Immunization, Passive, Male, Oxygen, SARS-CoV-2, Treatment Outcome, United States, COVID-19 Serotherapy, COVID-19 Drug Treatment
Abstract

ImportanceSARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen therapies reduce expression of TMPRSS2.ObjectiveTo determine if temporary androgen suppression induced by degarelix improves clinical outcomes of inpatients hospitalized with COVID-19.Design, setting, and participantsThe Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization (HITCH) phase 2, placebo-controlled, double-blind, randomized clinical trial compared efficacy of degarelix plus standard care vs placebo plus standard care on clinical outcomes in men hospitalized with COVID-19 but not requiring invasive mechanical ventilation. Inpatients were enrolled at 14 Department of Veterans Affairs hospitals from July 22, 2020, to April 8, 2021. Data were analyzed from August 9 to October 15, 2021.InterventionsPatients stratified by age, history of hypertension, and disease severity were centrally randomized 2:1 to degarelix, (1-time subcutaneous dose of 240 mg) or a saline placebo. Standard care included but was not limited to supplemental oxygen, antibiotics, vasopressor support, peritoneal dialysis or hemodialysis, intravenous fluids, remdesivir, convalescent plasma, and dexamethasone.Main outcomes and measuresThe composite primary end point was mortality, ongoing need for hospitalization, or requirement for mechanical ventilation at day 15 after randomization. Secondary end points were time to clinical improvement, inpatient mortality, length of hospitalization, duration of mechanical ventilation, time to achieve a temperature within reference range, maximum severity of COVID-19, and the composite end point at 30 days.ResultsThe trial was stopped for futility after the planned interim analysis, at which time there were 96 evaluable patients, including 62 patients randomized to the degarelix group and 34 patients in the placebo group, out of 198 initially planned. The median (range) age was 70.5 (48-85) years. Common comorbidities included chronic obstructive pulmonary disorder (15 patients [15.6%]), hypertension (75 patients [78.1%]), cardiovascular disease (27 patients [28.1%]), asthma (12 patients [12.5%]), diabetes (49 patients [51.0%]), and chronic respiratory failure requiring supplemental oxygen at baseline prior to COVID-19 (9 patients [9.4%]). For the primary end point, there was no significant difference between the degarelix and placebo groups (19 patients [30.6%] vs 9 patients [26.5%]; P = .67). Similarly, no differences were observed between degarelix and placebo groups in any secondary end points, including inpatient mortality (11 patients [17.7%] vs 6 patients [17.6%]) or all-cause mortality (11 patients [17.7%] vs 7 patents [20.6%]). There were no differences between degarelix and placebo groups in the overall rates of adverse events (13 patients [21.0%] vs 8 patients [23.5%) and serious adverse events (19 patients [30.6%] vs 13 patients [32.4%]), nor unexpected safety concerns.Conclusions and relevanceIn this randomized clinical trial of androgen suppression vs placebo and usual care for men hospitalized with COVID-19, degarelix did not result in amelioration of COVID-19 severity.Trial registrationClinicalTrials.gov Identifier: NCT04397718.

Published
2022

2. Relationships among structure, memory, and flow in sheared disordered materials

Author

Galloway, K. L., Teich, E. G., Ma, X-g, Kammer, Ch., Graham, I. R., Keim, N. C., Reina, C., Jerolmack, D. J., Yodh, A. G., and Arratia, P. E.

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, Physics - Fluid Dynamics
Abstract

A fundamental challenge for disordered solids is predicting macroscopic yield from the microscopic arrangements of constituent particles. Yield is accompanied by a sudden and large increase in energy dissipation due to the onset of plastic rearrangements. This suggests that one path to understanding bulk rheology is to map particle configurations to their mode of deformation. Here, we perform laboratory experiments and numerical simulations that are designed to do just that: 2D dense colloidal systems are subjected to oscillatory shear, and particle trajectories and bulk rheology are measured. We quantify particle microstructure using excess entropy. Results reveal a direct relation between excess entropy and energy dissipation, that is insensitive to the nature of interactions among particles. We use this relation to build a physically-informed model that connects rheology to microstructure. Our findings suggest a framework for tailoring the rheological response of disordered materials by tuning microstructural properties.

Published
2021
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3. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: Insights from the START study

Author

Steering Committee, De Luca (Chairman), L., Gulizia (co-chairman), M.M., Temporelli, P.L., Riccio, C., Colivicchi, F., Amico, A.F., Formigli, D., Geraci, G., Di Lenarda, A., Executive Committee, De Luca, L., Maggioni, A.P., Lucci, D., Coordinating Center, Lorimer, A., Orsini, G., Gonzini, L., Fabbri, G., Priami, P., Maras, P., Ramani, F., Falcone, C., Passarelli, I., Mauri, S., Calabrò, P., Bianchi, R., Di Palma, G., Mascia, F., Vetrano, A., Fusco, A., Proia, E., Aiello, A., Tomai, F., Licitra, R., Petrolini, A., Bosco, B., Magliari, F., Callerame, M., Mazzella, T., Lettica, G.V., Coco, G., Incao, F., Marinacci, L., D'Addario, S., Tartaglione, S.N., Ubaldi, S., Sanchez, F.A., Costa, P., Manca, G., Failla, M., Scherillo, M., Procaccini, V., Senni, M., Luminita, E.M., Bonomo, P., Mossa, C., Corda, S., Colavita, A.R., Trevisonno, G., Vizzari, G., Cosentino, N., Formaro, C., Paolillo, C., Nalin, I.L., De Rosa, F.M., Fontana, F., Fuscaldo, G.F., Passamonti, E., Bertella, E., Calvaruso, E.V., Varani, E., Tani, F., Cicchitelli, G., Gabrielli, D., Paoloni, P., Marziali, A., Campo, G., Tebaldi, M., Biscaglia, S., Biase, M Di, Brunetti, N.D., Gallotta, A.M., Mattei, L., Marini, R., Balsemin, F., Urbano, M.D., Naio, R., Vicinelli, P., Arena, G., Mazzini, M., Gigli, N., Miserrafiti, B., Monopoli, A., Mortara, A., Delfino, P., Chioffi, M.M., Marino, P., Gravellone, M., Barbieri, L., Ledda, A., Carmina, M.G., Raisaro, A.E., Di Giacomo, C., Somaschini, A., Fasano, M.L., Sannazzaro, M., Arcieri, R., Pantaleoni, M., Leuzzi, C., Gorlato, G., Greco, G., Chiera, A., Ammaturo, T.A., Malanchini, G., Del Corral, M.P., Tedesco, L., Pede, S., Urso, L.G., Piscione, F., Galasso, G., Provasoli, S., Fattore, L., Lucca, G., Cresti, A., Cardillo, A., Fera, M.S., Vennettilli, F., Gaudio, C., Paravati, V., Caldarola, P., Locuratolo, N., Verlato, R., De Conti, F., Turiano, G., Preti, G., Moretti, L., Silenzi, S., Colonna, G., Picciolo, A., Nicosia, A., Cascone, C., Di Sciascio, G., Mangiacapra, F., Russo, A., Mastroianno, S., Esposito, G., Cosmi, F., D'Orazio, S., Costantini, C., Lanari, A., De Rosa, P., Esposito, L., Bilato, C., Valle, C Dalla, Ceresa, M., Colombo, E., Pennisi, V., Casciola, G., Driussi, M., Bisceglia, T., Scalvini, S., Rivadossi, F., Volpe, M., Comito, F., Scorzoni, D., Grimoldi, P., Lagioia, R., Santoro, D., De Cesare, N., Comotti, T., Poli, A., Martina, P., Musolino, M.F., Multari, E.I., Bilardo, G., Scalchi, G., Olivieri, C., Caranci, F., Pavan, D., Ganci, G., Mariani, A., Falchetti, E., Lanzillo, T., Caccavale, A., Bongo, A.S., Rizzi, A., Favilli, R., Maffei, S., Mallardo, M., Fulgione, C., Bordin, F., Bonmassari, R., Battaia, E., Puzzo, A., Vianello, G., D'Arpino, A., Romei, M., Pajes, G., Petronzelli, S., Ghezzi, F., Brigido, S., Pignatelli, L., Brscic, E., Sori, P., Russo, M., Biancolillo, E., Ignone, G., De Giorgio, N.A., Campaniello, C., Ponticelli, P., Margonato, A., Gerosa, S., Cutaia, A., Casalicchio, C., Bartolomucci, F., Larosa, C., Spadafina, T., Putignano, A., De Cristofaro, R., Bernardi, L., Sommariva, L., Celestini, A., Bertucci, C.M., Marchetti, M., Grisolia, E Franceschini, Ammendolea, C., Carini, M., Scipione, P., Politano, M., Rubino, G., Reina, C., Peccerillo, N., Paloscia, L., D'Alleva, A., Petacchi, R., Pignalosa, M., Lucchetti, D., Di Palma, F., La Mastra, R.A., Filippis, M De, Fontanella, B., Zanini, G., Casolo, G., Del Meglio, J., Parato, V.M., Genovesi, E., D'Alimonte, A., Miglioranza, A., Alessandri, N., Moscariello, F., Mauro, C., Sasso, A., Caso, P., Petrillo, C., Napoletano, C., Paparoni, S.R., Bernardo, V., Serdoz, R., Rotunno, R., Oppo, I., Aloisio, A., Aurelio, A., Licciardello, G., Cassaniti, L., Gulizia, M.M., Francese, G.M., Marcassa, C., Villani, R., Zorzoli, F., Mileto, F., Vecchis, M De, Scolozzi, D., Lupi, G., Caruso, D., Rebulla, E., La Fata, B., Anselmi, M., Girardi, P., Borruso, E., Ferrantelli, G., Sassone, B., Bressan, S., Capriolo, M., Pelissero, E., Piancastelli, M., Gobbi, M., Cocco, F., Bruno, M.G., Berti, S., Lo Surdo, G., Tanzi, P., De Rosa, R., Vilei, E., De Iaco, M.R., Grassi, G., Zanella, C., Marullo, L., Alfano, G., Pelaggi, P., Talarico, R., Tuccillo, B., Irace, L., Proietti, F., Di Croce, G., Di Lorenzo, L., Zarrilli, A., Bongini, M., Ranise, A., Aprile, A., Fornengo, C., Capogrosso, V., Tranghese, A., Golia, B., Marziano, A., Roncon, L., Picariello, C., Bagni, E., Leci, E., Gregorio, G., Gatto, F., Piemonte, F., Gervasio, F., Navazio, A., Guerri, E., Belmonte, E., Marino, F., Di Belardino, N., Di Nuzzo, M.R., Epifani, M., Comolatti, G., Conconi, B., Benea, D., Casu, G., Merella, P., Ammirati, M.A., Corrado, V.M., Spagnolo, D., Caico, S.I., Bonizzato, S., Margheri, M., Corrado, L., Antonicelli, R., Ferrigno, C., Merlino, A., Nassiacos, D., Antonelli, A., Marchese, A., Uguccioni, M., Villella, A., Bechi, S., Lo Bianco, F., Bedogni, F., Negro, L., Donato, L., Statile, D., Cassin, M., Fedele, F., Granatelli, A., Calcagno, S., Politi, A., Pani, A., De Luca, Leonardo, Temporelli, Pier Luigi, Gulizia, Michele Massimo, Gonzini, Lucio, Ammaturo, Tiziana Anita, Tedesco, Luigi, Pede, Silvia, Oliva, Fabrizio, Gabrielli, Domenico, Colivicchi, Furio, and Averna, Maurizio R.

Published
2023
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14. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: insights from the START Study

Author

De Luca, Leonardo, primary, Temporelli, Pier Luigi, additional, Gulizia, Michele Massimo, additional, Gonzini, Lucio, additional, Ammaturo, Tiziana Anita, additional, Tedesco, Luigi, additional, Pede, Silvia, additional, Oliva, Fabrizio, additional, Gabrielli, Domenico, additional, Colivicchi, Furio, additional, Averna, Maurizio R., additional, De Luca, L., additional, Gulizia, M.M., additional, Temporelli, P.L., additional, Riccio, C., additional, Colivicchi, F., additional, Amico, A.F., additional, Formigli, D., additional, Geraci, G., additional, Di Lenarda, A., additional, Maggioni, A.P., additional, Lucci, D., additional, Lorimer, A., additional, Orsini, G., additional, Gonzini, L., additional, Fabbri, G., additional, Priami, P., additional, Maras, P., additional, Ramani, F., additional, Falcone, C., additional, Passarelli, I., additional, Mauri, S., additional, Calabrò, P., additional, Bianchi, R., additional, Di Palma, G., additional, Mascia, F., additional, Vetrano, A., additional, Fusco, A., additional, Proia, E., additional, Aiello, A., additional, Tomai, F., additional, Licitra, R., additional, Petrolini, A., additional, Bosco, B., additional, Magliari, F., additional, Callerame, M., additional, Mazzella, T., additional, Lettica, G.V., additional, Coco, G., additional, Incao, F., additional, Marinacci, L., additional, D'Addario, S., additional, Tartaglione, S.N., additional, Ubaldi, S., additional, Sanchez, F.A., additional, Costa, P., additional, Manca, G., additional, Failla, M., additional, Scherillo, M., additional, Procaccini, V., additional, Senni, M., additional, Luminita, E.M., additional, Bonomo, P., additional, Mossa, C., additional, Corda, S., additional, Colavita, A.R., additional, Trevisonno, G., additional, Vizzari, G., additional, Cosentino, N., additional, Formaro, C., additional, Paolillo, C., additional, Nalin, I.L., additional, De Rosa, F.M., additional, Fontana, F., additional, Fuscaldo, G.F., additional, Passamonti, E., additional, Bertella, E., additional, Calvaruso, E.V., additional, Varani, E., additional, Tani, F., additional, Cicchitelli, G., additional, Gabrielli, D., additional, Paoloni, P., additional, Marziali, A., additional, Campo, G., additional, Tebaldi, M., additional, Biscaglia, S., additional, Biase, M Di, additional, Brunetti, N.D., additional, Gallotta, A.M., additional, Mattei, L., additional, Marini, R., additional, Balsemin, F., additional, Urbano, M.D., additional, Naio, R., additional, Vicinelli, P., additional, Arena, G., additional, Mazzini, M., additional, Gigli, N., additional, Miserrafiti, B., additional, Monopoli, A., additional, Mortara, A., additional, Delfino, P., additional, Chioffi, M.M., additional, Marino, P., additional, Gravellone, M., additional, Barbieri, L., additional, Ledda, A., additional, Carmina, M.G., additional, Raisaro, A.E., additional, Di Giacomo, C., additional, Somaschini, A., additional, Fasano, M.L., additional, Sannazzaro, M., additional, Arcieri, R., additional, Pantaleoni, M., additional, Leuzzi, C., additional, Gorlato, G., additional, Greco, G., additional, Chiera, A., additional, Ammaturo, T.A., additional, Malanchini, G., additional, Del Corral, M.P., additional, Tedesco, L., additional, Pede, S., additional, Urso, L.G., additional, Piscione, F., additional, Galasso, G., additional, Provasoli, S., additional, Fattore, L., additional, Lucca, G., additional, Cresti, A., additional, Cardillo, A., additional, Fera, M.S., additional, Vennettilli, F., additional, Gaudio, C., additional, Paravati, V., additional, Caldarola, P., additional, Locuratolo, N., additional, Verlato, R., additional, De Conti, F., additional, Turiano, G., additional, Preti, G., additional, Moretti, L., additional, Silenzi, S., additional, Colonna, G., additional, Picciolo, A., additional, Nicosia, A., additional, Cascone, C., additional, Di Sciascio, G., additional, Mangiacapra, F., additional, Russo, A., additional, Mastroianno, S., additional, Esposito, G., additional, Cosmi, F., additional, D'Orazio, S., additional, Costantini, C., additional, Lanari, A., additional, De Rosa, P., additional, Esposito, L., additional, Bilato, C., additional, Valle, C Dalla, additional, Ceresa, M., additional, Colombo, E., additional, Pennisi, V., additional, Casciola, G., additional, Driussi, M., additional, Bisceglia, T., additional, Scalvini, S., additional, Rivadossi, F., additional, Volpe, M., additional, Comito, F., additional, Scorzoni, D., additional, Grimoldi, P., additional, Lagioia, R., additional, Santoro, D., additional, De Cesare, N., additional, Comotti, T., additional, Poli, A., additional, Martina, P., additional, Musolino, M.F., additional, Multari, E.I., additional, Bilardo, G., additional, Scalchi, G., additional, Olivieri, C., additional, Caranci, F., additional, Pavan, D., additional, Ganci, G., additional, Mariani, A., additional, Falchetti, E., additional, Lanzillo, T., additional, Caccavale, A., additional, Bongo, A.S., additional, Rizzi, A., additional, Favilli, R., additional, Maffei, S., additional, Mallardo, M., additional, Fulgione, C., additional, Bordin, F., additional, Bonmassari, R., additional, Battaia, E., additional, Puzzo, A., additional, Vianello, G., additional, D'Arpino, A., additional, Romei, M., additional, Pajes, G., additional, Petronzelli, S., additional, Ghezzi, F., additional, Brigido, S., additional, Pignatelli, L., additional, Brscic, E., additional, Sori, P., additional, Russo, M., additional, Biancolillo, E., additional, Ignone, G., additional, De Giorgio, N.A., additional, Campaniello, C., additional, Ponticelli, P., additional, Margonato, A., additional, Gerosa, S., additional, Cutaia, A., additional, Casalicchio, C., additional, Bartolomucci, F., additional, Larosa, C., additional, Spadafina, T., additional, Putignano, A., additional, De Cristofaro, R., additional, Bernardi, L., additional, Sommariva, L., additional, Celestini, A., additional, Bertucci, C.M., additional, Marchetti, M., additional, Grisolia, E Franceschini, additional, Ammendolea, C., additional, Carini, M., additional, Scipione, P., additional, Politano, M., additional, Rubino, G., additional, Reina, C., additional, Peccerillo, N., additional, Paloscia, L., additional, D'Alleva, A., additional, Petacchi, R., additional, Pignalosa, M., additional, Lucchetti, D., additional, Di Palma, F., additional, La Mastra, R.A., additional, Filippis, M De, additional, Fontanella, B., additional, Zanini, G., additional, Casolo, G., additional, Del Meglio, J., additional, Parato, V.M., additional, Genovesi, E., additional, D'Alimonte, A., additional, Miglioranza, A., additional, Alessandri, N., additional, Moscariello, F., additional, Mauro, C., additional, Sasso, A., additional, Caso, P., additional, Petrillo, C., additional, Napoletano, C., additional, Paparoni, S.R., additional, Bernardo, V., additional, Serdoz, R., additional, Rotunno, R., additional, Oppo, I., additional, Aloisio, A., additional, Aurelio, A., additional, Licciardello, G., additional, Cassaniti, L., additional, Francese, G.M., additional, Marcassa, C., additional, Villani, R., additional, Zorzoli, F., additional, Mileto, F., additional, Vecchis, M De, additional, Scolozzi, D., additional, Lupi, G., additional, Caruso, D., additional, Rebulla, E., additional, La Fata, B., additional, Anselmi, M., additional, Girardi, P., additional, Borruso, E., additional, Ferrantelli, G., additional, Sassone, B., additional, Bressan, S., additional, Capriolo, M., additional, Pelissero, E., additional, Piancastelli, M., additional, Gobbi, M., additional, Cocco, F., additional, Bruno, M.G., additional, Berti, S., additional, Lo Surdo, G., additional, Tanzi, P., additional, De Rosa, R., additional, Vilei, E., additional, De Iaco, M.R., additional, Grassi, G., additional, Zanella, C., additional, Marullo, L., additional, Alfano, G., additional, Pelaggi, P., additional, Talarico, R., additional, Tuccillo, B., additional, Irace, L., additional, Proietti, F., additional, Di Croce, G., additional, Di Lorenzo, L., additional, Zarrilli, A., additional, Bongini, M., additional, Ranise, A., additional, Aprile, A., additional, Fornengo, C., additional, Capogrosso, V., additional, Tranghese, A., additional, Golia, B., additional, Marziano, A., additional, Roncon, L., additional, Picariello, C., additional, Bagni, E., additional, Leci, E., additional, Gregorio, G., additional, Gatto, F., additional, Piemonte, F., additional, Gervasio, F., additional, Navazio, A., additional, Guerri, E., additional, Belmonte, E., additional, Marino, F., additional, Di Belardino, N., additional, Di Nuzzo, M.R., additional, Epifani, M., additional, Comolatti, G., additional, Conconi, B., additional, Benea, D., additional, Casu, G., additional, Merella, P., additional, Ammirati, M.A., additional, Corrado, V.M., additional, Spagnolo, D., additional, Caico, S.I., additional, Bonizzato, S., additional, Margheri, M., additional, Corrado, L., additional, Antonicelli, R., additional, Ferrigno, C., additional, Merlino, A., additional, Nassiacos, D., additional, Antonelli, A., additional, Marchese, A., additional, Uguccioni, M., additional, Villella, A., additional, Bechi, S., additional, Lo Bianco, F., additional, Bedogni, F., additional, Negro, L., additional, Donato, L., additional, Statile, D., additional, Cassin, M., additional, Fedele, F., additional, Granatelli, A., additional, Calcagno, S., additional, Politi, A., additional, and Pani., A., additional

Published
2023
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16. Coda

Author

van der Wiel, Reina C. and van der Wiel, Reina C.

Published
2014
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24. Enhanced gauge symmetries on elliptic K3

Author

Bonora, L., Reina, C., and Zampa, A.

Subjects
High Energy Physics - Theory
Abstract

We show that the geometry of K3 surfaces with singularities of type A-D-E contains enough information to reconstruct a copy of the Lie algebra associated to the given Dynkin diagram. We apply this construction to explain the enhancement of symmetry in F and IIA theories compactified on singular K3's., Comment: 9 pages, Latex

Published
1998
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25. The Johns Hopkins University Center for Systems Science and Engineering COVID-19 Dashboard: data collection process, challenges faced, and lessons learned

Author

Ensheng Dong, Jeremy Ratcliff, Tamara D Goyea, Aaron Katz, Ryan Lau, Timothy K Ng, Beatrice Garcia, Evan Bolt, Sarah Prata, David Zhang, Reina C Murray, Mara R Blake, Hongru Du, Fardin Ganjkhanloo, Farzin Ahmadi, Jason Williams, Sayeed Choudhury, and Lauren M Gardner

Subjects
Infectious Diseases, Universities, Data Collection, Humans, COVID-19, Public Health
Abstract

On Jan 22, 2020, a day after the USA reported its first COVID-19 case, the Johns Hopkins University Center for Systems Science and Engineering (JHU CSSE) launched the first global real-time coronavirus surveillance system: the JHU CSSE COVID-19 Dashboard. As of June 1, 2022, the dashboard has served the global audience for more than 30 consecutive months, totalling over 226 billion feature layer requests and 3·6 billion page views. The highest daily record was set on March 29, 2020, with more than 4·6 billion requests and over 69 million views. This Personal View reveals the fundamental technical details of the entire data system underlying the dashboard, including data collection, data fusion logic, data curation and sharing, anomaly detection, data corrections, and the human resources required to support such an effort. The Personal View also covers the challenges, ranging from data visualisation to reporting standardisation. The details presented here help develop a framework for future, large-scale public health-related data collection and reporting.

Published
2022
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26. Topological Observables in Semiclassical Field Theories

Author

Nolasco, M. and Reina, C.

Subjects
High Energy Physics - Theory
Abstract

We give a geometrical set up for the semiclassical approximation to euclidean field theories having families of minima (instantons) parametrized by suitable moduli spaces ${\cal M}$. The standard examples are of course Yang-Mills theory and non-linear $\sigma$-models. The relevant space here is a family of measure spaces $\tilde {\cal N} \ra {\cal M}$, with standard fibre a distribution space, given by a suitable extension of the normal bundle to ${\cal M}$ in the space of smooth fields. Over $\tilde {\cal N}$ there is a probability measure $d\mu$ given by the twisted product of the (normalized) volume element on ${\cal M}$ and the family of gaussian measures with covariance given by the tree propagator $C_\phi$ in the background of an instanton $\phi \in {\cal M}$. The space of ``observables", i.e. measurable functions on ($\tilde {\cal N}, \, d\mu$), is studied and it is shown to contain a topological sector, corresponding to the intersection theory on ${\cal M}$. The expectation value of these topological ``observables" does not depend on the covariance; it is therefore exact at all orders in perturbation theory and can moreover be computed in the topological regime by setting the covariance to zero., Comment: 11 pages

Published
1992
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28. Risk of diabetes in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study

Author

O’Connor-Reina, C. (Carlos), Rodriguez-Alcala, L. (Laura), Ignacio, J.M. (José María), Garcia-Iriarte, M.T. (Maria Teresa), Carrasco-Llatas, M. (Marina), Casado-Morente, J.C. (Juan Carlos), Pérez-del-Rey, D. (David), Marban-Álvarez, I.(Irene), Hernandez-Ibarburu, G. (Gema), Baptista, P.M. (Peter M.), and Plaza-Mayor, G. (Guillermo)

Subjects
Big data, Survival, Diabetes, Sleep apnea, Upper airway surgery, Continuous positive airway pressure (CPAP)
Abstract

This study aimed to obtain a comprehensive view of the risk of developing diabetes in patients with obstructive sleep apnea (OSA) and to compare this risk between patients receiving continuous positive airway pressure (CPAP) therapy versus upper airway surgery (UAS). We used local and the global-scale federated data research network TriNetX to obtain access to electronic medical records, including those for patients diagnosed with OSA, from health-care organizations (HCOs) worldwide. Using propensity score matching and the score-matched analyses of data for 5 years of follow-up, we found that patients who had undergone UAS had a lower risk of developing diabetes than those who used CPAP (risk ratio 0.415, 95% confidence interval (CI) 0.349-0.493). The risk for newly diagnosed diabetes patients showed a similar pattern (hazard ratio 0.382; 95% CI 0.317-0.459). Both therapies seem to protect against diabetes (Risk 0.081 after UAS vs. 0.195 after CPAP). Analysis of the large data sets collected from HCOs in Europe and globally lead us to conclude that, in patients with OSA, UAS can prevent the development of diabetes better than CPAP.

Published
2023

35. COMPASS criteria applied to a contemporary cohort of unselected patients with stable coronary artery diseases: Insights from the STARTregistry

Author

De Luca, L, Formigli, D, Meessen, J, Uguccioni, M, Cosentino, N, Paolillo, C, Di Lenarda, A, Colivicchi, F, Gabrielli, D, Gulizia, M, Scherillo, M, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Formaro, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Di Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, D'Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Geraci, G, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Ammaturo, T, Malanchini, G, Del Corral, M, Tedesco, L, Pede, S, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Dalla Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, Se Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Franceschini Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Amico, A, De Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Temporelli, P, Villani, R, Zorzoli, F, Mileto, F, De Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, Pani, A, De Luca L., Formigli D., Meessen J., Uguccioni M., Cosentino N., Paolillo C., Di Lenarda A., Colivicchi F., Gabrielli D., Gulizia M. M., Scherillo M., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Formaro C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Di Biase M., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., D'Urbano M., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Geraci G., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Ammaturo T. A., Malanchini G., Del Corral M. P., Tedesco L., Pede S., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Dalla Valle C., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., Se Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Franceschini Grisolia E., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Amico A. F., De Filippis M., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Temporelli P. L., Villani R., Zorzoli F., Mileto F., De Vecchis M., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., Pani A., De Luca, L, Formigli, D, Meessen, J, Uguccioni, M, Cosentino, N, Paolillo, C, Di Lenarda, A, Colivicchi, F, Gabrielli, D, Gulizia, M, Scherillo, M, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Formaro, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Di Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, D'Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Geraci, G, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Ammaturo, T, Malanchini, G, Del Corral, M, Tedesco, L, Pede, S, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Dalla Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, Se Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Franceschini Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Amico, A, De Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Temporelli, P, Villani, R, Zorzoli, F, Mileto, F, De Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, Pani, A, De Luca L., Formigli D., Meessen J., Uguccioni M., Cosentino N., Paolillo C., Di Lenarda A., Colivicchi F., Gabrielli D., Gulizia M. M., Scherillo M., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Formaro C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Di Biase M., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., D'Urbano M., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Geraci G., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Ammaturo T. A., Malanchini G., Del Corral M. P., Tedesco L., Pede S., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Dalla Valle C., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., Se Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Franceschini Grisolia E., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Amico A. F., De Filippis M., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Temporelli P. L., Villani R., Zorzoli F., Mileto F., De Vecchis M., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., and Pani A.

Abstract

Aims Recently, the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial demonstrated that dual therapy reduced cardiovascular outcomes compared with aspirin alone in patients with stable atherosclerotic disease. Methods and We sought to assess the proportion of patients eligible for the COMPASS trial and to compare the epidemiology results and outcome of these patients with those without COMPASS inclusion or with any exclusion criteria in a contemporary, nationwide cohort of patients with stable coronary artery disease. Among the 4068 patients with detailed information allowing evaluation of eligibility, 1416 (34.8%) did not fulfil the inclusion criteria (COMPASS-Not-Included), 841 (20.7%) had exclusion criteria (COMPASS-Excluded), and the remaining 1811 (44.5%) were classified as COMPASS-Like. At 1 year, the incidence of major adverse cardiovascular event (MACE), a composite of cardiovascular death, myocardial infarction, and stroke, was 0.9% in the COMPASS-Not-Included and 2.0% in the COMPASS-Like (P = 0.01), and 5.0% in the COMPASS-Excluded group (P < 0.0001 for all comparisons). Among the COMPASS-Like population, patients with multiple COMPASS enrichment criteria presented a significant increase in the risk of MACE (from 1.0% to 3.3% in those with 1 and >_3 criteria, respectively; P = 0.012), and a modest absolute increase in major bleeding risk (from 0.2% to 0.4%, respectively; P = 0.46). Conclusion In a contemporary real-world cohort registry of stable coronary artery disease, most patients resulted as eligible for the COMPASS. These patients presented a considerable annual risk of MACE that consistently increases in the presence of multiple risk factors.

Published
2021

37. Settler colonial conscripts: Mennonite reserves and the enfolding of implicated subjects

Author

Reina C. Neufeldt

Subjects
History, Settler colonial, media_common.quotation_subject, Political Science and International Relations, Immigration, Ethnology, Model minority, Indigenous, media_common
Abstract

Indigenous resurgence movements in states like Canada and the U.S. have challenged immigrant and settler groups to confront their presence on colonized lands, and transform their relations with lan...

Published
2021
Full Text
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38. Composition and geographic variation of the bacterial microbiota associated with the coelomic fluid of the sea urchin Paracentrotus lividus

Author

Faddetta, T, Ardizzone, F, Faillaci, F, Reina, C, Palazzotto, E, Strati, F, De Filippo, C, Spinelli, G, Puglia, A, Gallo, G, Cavalieri, V, Faddetta T, Ardizzone F, Faillaci F, Reina C, Palazzotto E, Strati F, De Filippo C, Spinelli G, Puglia A.M, Gallo G, Cavalieri V., Faddetta, T, Ardizzone, F, Faillaci, F, Reina, C, Palazzotto, E, Strati, F, De Filippo, C, Spinelli, G, Puglia, A, Gallo, G, Cavalieri, V, Faddetta T, Ardizzone F, Faillaci F, Reina C, Palazzotto E, Strati F, De Filippo C, Spinelli G, Puglia A.M, Gallo G, and Cavalieri V.

Abstract

In the present work, culture-based and culture-independent investigations were performed to determine the microbiota structure of the coelomic fluid of Mediterranean sea urchin Paracentrotus lividus individuals collected from two distinct geographical sites neighboring a high-density population bay and a nature reserve, respectively. Next Generation Sequencing analysis of 16S rRNA gene (rDNA) showed that members of the Proteobacteria, Bacteroidetes and Fusobacteria phyla, which have been previously reported to be commonly retrieved from marine invertebrates, dominate the overall population of microorganisms colonizing this liquid tissue, with minority bacterial genera exhibiting remarkable differences among individuals. Our results showed that there is a correlation between microbiota structure and geographical location of the echinoderm collection site, highlighting over-representation of metagenomic functions related to amino acid and bioactive peptides metabolism in specimens inhabiting the nature reserve. Finally, we also described the developmental delay and aberrations exhibited by sea urchin embryos exposed to distinct bacterial isolates, and showed that these defects rely upon hydrophilic compound(s) synthesized by the bacterial strains assayed. Altogether, our findings lay the groundwork to decipher the relationships of bacteria with sea urchins in their aquatic environment, also providing an additional layer of information to understand the biological roles of the coelomic fluid.

Published
2020

39. Scalable Probabilistic Clustering

Author

Bradley, P. S., Fayyad, U. M., Reina, C. A., Pardalos, Panos M., editor, Hearn, Donald, editor, Ferris, Michael C., editor, Mangasarian, Olvi L., editor, and Pang, Jong-Shi, editor

Published
2001
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40. Recovery of dialysis patients with COVID-19: health outcomes 3 months after diagnosis in ERACODA

Author

Hemmelder, M. H., Noordzij, M., Vart, P., Hilbrands, L. B., Jager, K. J., Abrahams, A. C., Arroyo, D., Battaglia, Y., Ekart, R., Mallamaci, F., Malloney, S. -R., Oliveira, J., Rydzewski, A., Sridharan, S., Vogt, L., Duivenvoorden, R., Gansevoort, R. T., Franssen, C. F. M., van der Net, J. B., Essig, M., du Buf-Vereijken, P. W. G., van Ginneken, B., Maas, N., van Jaarsveld, B. C., Bemelman, F. J., Klingenberg-Salahova, F., Heenan-Vos, F., Vervloet, M. G., Nurmohamed, A., Abramowicz, D., Verhofstede, S., Maoujoud, O., Malfait, T., Fialova, J., Melilli, E., Fava, A., Cruzado, J. M., Perez, N. M., Lips, J., Krepel, H., Adilovic, H., Hengst, M., Konings, C. J. A. M., Braconnier, P., Weis, D., Gellert, R., Alferes, D. G., Radulescu, D., Zakharova, E. V., Ambuehl, P. M., Guidotti, R., Walker, A., Lepeytre, F., Rabate, C., Rostoker, G., Marques, S., Azasevac, T., Majstorovic, G. S., Katicic, D., Dam, M. T., Kruger, T., Brzosko, S., Liakopoulos, V., Zanen, A. L., Logtenberg, S. J. J., Fricke, L., Kuryata, O., Slebe, J. J. P., Abd ElHafeez, S., Kemlin, D., van de Wetering, J., Reinders, M. E. J., Hesselink, D. A., van Gestel, J. K., Eiselt, J., Kielberger, L., El-Wakil, H. S., Verhoeven, M. A. M., Logan, I., Canal, C., Facundo, C., Ramos, A. M., Debska-Slizien, A., Veldhuizen, N. M. H., Tigka, E., Polyzou Konsta, M. A., Panagoutsos, S., Postorino, A., Cambareri, F., Matceac, I., Nistor, I., Covic, A., Groeneveld, J. H. M., Jousma, J., Diekmann, F., Oppenheimer, F., Blasco, M., Pereira, T. A., dos Santos Junior, A. C. S., Arias-Cabrales, C., Crespo, M., Llinas-Mallol, L., Buxeda, A., Tarrega, C. B., Redondo-Pachon, D., Arenas Jimenez, M. D., Mendoza-Valderrey, A., Martins, A. C., Mateus, C., Alvila, G., Laranjinha, I., Hofstra, J. M., Siezenga, M. A., Franco, A., Castellano, S., Rodriguez-Ferrero, M. L., Manzanos, S. B., Haridian Sosa Barrios, R., Lemahieu, W., Bartelet, K., Dirim, A. B., Demir, E., Sever, M. S., Turkmen, A., Safak, S., Hollander, D. A. M. J., Kerckhoffs, A., Buttner, S., de Vries, A. P. J., Meziyerh, S., van der Helm, D., Mallat, M., Bouwsma, H., Petruliene, K., Verberk, I., van der Sande, F. M., Christiaans, M. H. L., Mohankumar, N., Luca, M. D., Tuglular, S. Z., Kramer, A., Beerenhout, C., Luik, P. T., Kerschbaum, J., Tiefenthaler, M., Watschinger, B., Adema, A. Y., Stepanov, V. A., Zulkarnaev, A. B., Turkmen, K., Gandolfini, I., Maggiore, U., Fliedner, A., Asberg, A., Mjoen, G., Miyasato, H., de Fijter, C. W. H., Mongera, N., Pini, S., de Biase, C., van de Logt, A. E., Maas, R., Lebedeva, O., Lopez, V., Reichert, L. J. M., Verhave, J., Titov, D., Parshina, E. V., Zanoli, L., Marcantoni, C., van Kempen, G., van Gils-Verrij, L. E. A., Harty, J. C., Meurs, M., Myslak, M., Lentini, P., den Deurwaarder, E., Stendahl, M., Rahimzadeh, H., Schouten, M., Rychlik, I., Cabezas-Reina, C. J., Roca, A. M., Nauta, F., Sahin, I., Goffin, E., Kanaan, N., Labriola, L., Devresse, A., Diaz-Mareque, A., Coca, A., de Arriba, G., Meijers, B. K. I., Naesens, M., Kuypers, D., Desschans, B., Tonnerlier, A., Wissing, K. M., Dedinska, I., Pessolano, G., Malik, S., Dounousi, E., Papachristou, E., Berger, S. P., Meijer, E., Sanders, J. S. F., Ozyilmaz, A., Ponikvar, J. B., Pernat, A. M., Kovac, D., Arnol, M., Molenaar, F. M., van Zuilen, A. D., Meijvis, S. C. A., Dolmans, H., Tantisattamo, E., Esposito, P., Krzesinski, J. -M., Barahira, J. D., Gallieni, M., Martin-Moreno, P. L., Guglielmetti, G., Guzzo, G., Toapanta, N., Soler, M. J., Luik, A. J., van Kuijk, W. H. M., Stikkelbroeck, L. W. H., Hermans, M. M. H., Rimsevicius, L., Righetti, M., Islam, M., Heitink-Ter Braak, N., Nephrology, ACS - Microcirculation, ACS - Diabetes & metabolism, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Clinical sciences, Faculteit Medische Wetenschappen/UMCG, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Interne Geneeskunde, RS: Carim - V02 Hypertension and target organ damage, Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, APH - Health Behaviors & Chronic Diseases, and Internal Medicine

Subjects
Male, Outcome Assessment, survival, mental health status, COVID-19 Testing, SDG 3 - Good Health and Well-being, Renal Dialysis, functional health status, Outcome Assessment, Health Care, 80 and over, Humans, KIDNEY-TRANSPLANT, AcademicSubjects/MED00340, Aged, Aged, 80 and over, Transplantation, SARS-CoV-2, MORTALITY, COVID-19, Middle Aged, Health Care, Intensive Care Units, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nephrology, dialysis, Original Article, Female, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract

Background Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis. Methods We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8–6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis.

Published
2022
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41. From Righteous to Responsive

Author

Reina C. Neufeldt

Abstract

This chapter investigates how individual unwillingness to examine core values can provide unmerited justification for certain policies and prevent important and thoughtful deliberation with affected parties. It offers several recommendations for promoting ethical reflection and humility in peacebuilding, which in turn can democratize leadership opportunities. In particular, the chapter proposes an “action-reflection” model to help peacebuilding practitioners think clearly and ethically about the implications of their good interventions. Critical self-reflection along these lines is also necessary within peacebuilding organizations, especially if these organizations want to avoid falling into patterns that have been shown to limit individual members' ability to reflect ethically. This includes, for example, groupthink scenarios and a focus on procedures and process over substantive outcomes. Without a mechanism for such action-reflection, it becomes exceedingly difficult for the peacebuilder to avoid co-optation, to balance donor demands with local integrity, or to decide how to formulate, prioritize, and change goals in shifting contexts.

Published
2022
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42. Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19: The HITCH Randomized Clinical Trial.

Author

Nickols, Nicholas G, Nickols, Nicholas G, Mi, Zhibao, DeMatt, Ellen, Biswas, Kousick, Clise, Christina E, Huggins, John T, Maraka, Spyridoula, Ambrogini, Elena, Mirsaeidi, Mehdi S, Levin, Ellis R, Becker, Daniel J, Makarov, Danil V, Adorno Febles, Victor, Belligund, Pooja M, Al-Ajam, Mohammad, Muthiah, Muthiah P, Montgomery, Robert B, Robinson, Kyle W, Wong, Yu-Ning, Bedimo, Roger J, Villareal, Reina C, Aguayo, Samuel M, Schoen, Martin W, Goetz, Matthew B, Graber, Christopher J, Bhattacharya, Debika, Soo Hoo, Guy, Orshansky, Greg, Norman, Leslie E, Tran, Samantha, Ghayouri, Leila, Tsai, Sonny, Geelhoed, Michelle, Rettig, Mathew B, Nickols, Nicholas G, Nickols, Nicholas G, Mi, Zhibao, DeMatt, Ellen, Biswas, Kousick, Clise, Christina E, Huggins, John T, Maraka, Spyridoula, Ambrogini, Elena, Mirsaeidi, Mehdi S, Levin, Ellis R, Becker, Daniel J, Makarov, Danil V, Adorno Febles, Victor, Belligund, Pooja M, Al-Ajam, Mohammad, Muthiah, Muthiah P, Montgomery, Robert B, Robinson, Kyle W, Wong, Yu-Ning, Bedimo, Roger J, Villareal, Reina C, Aguayo, Samuel M, Schoen, Martin W, Goetz, Matthew B, Graber, Christopher J, Bhattacharya, Debika, Soo Hoo, Guy, Orshansky, Greg, Norman, Leslie E, Tran, Samantha, Ghayouri, Leila, Tsai, Sonny, Geelhoed, Michelle, and Rettig, Mathew B

Abstract

ImportanceSARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen therapies reduce expression of TMPRSS2.ObjectiveTo determine if temporary androgen suppression induced by degarelix improves clinical outcomes of inpatients hospitalized with COVID-19.Design, setting, and participantsThe Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization (HITCH) phase 2, placebo-controlled, double-blind, randomized clinical trial compared efficacy of degarelix plus standard care vs placebo plus standard care on clinical outcomes in men hospitalized with COVID-19 but not requiring invasive mechanical ventilation. Inpatients were enrolled at 14 Department of Veterans Affairs hospitals from July 22, 2020, to April 8, 2021. Data were analyzed from August 9 to October 15, 2021.InterventionsPatients stratified by age, history of hypertension, and disease severity were centrally randomized 2:1 to degarelix, (1-time subcutaneous dose of 240 mg) or a saline placebo. Standard care included but was not limited to supplemental oxygen, antibiotics, vasopressor support, peritoneal dialysis or hemodialysis, intravenous fluids, remdesivir, convalescent plasma, and dexamethasone.Main outcomes and measuresThe composite primary end point was mortality, ongoing need for hospitalization, or requirement for mechanical ventilation at day 15 after randomization. Secondary end points were time to clinical improvement, inpatient mortality, length of hospitalization, duration of mechanical ventilation, time to achieve a temperature within reference range, maximum severity of COVID-19, and the composite end point at 30 days.ResultsThe trial was stopped for futility after the planned interim analysis, at which time there were 96 evaluable patients, including 62 patients randomized to the degarelix group and 34 patients in the placebo group, out of 198 initially planned. The median (range) age was 70.5 (48-85) years. Common comorbidities included chronic o

Published
2022

44. Gaps in knowledge about local peacebuilding: a study in deficiency from Jos, Nigeria

Author

Jessica Dyck, Reina C. Neufeldt, Mugu Zakka Bako, Mary Lou Klassen, and John Danboyi

Subjects
Political science, 05 social sciences, Social change, Peacebuilding, 050602 political science & public administration, Context (language use), Development, Public administration, 050601 international relations, 0506 political science, Front (military)
Abstract

The emphasis on local or hybrid efforts in peacebuilding literature brings front and centre the importance of being rooted within a particular context, with leadership and vision for social change ...

Published
2020
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45. Learning from and with community-based and participatory action research: Constraints and adaptations in a youth-peacebuilding initiative in Haiti

Author

Reina C Neufeldt and Rich Janzen

Subjects
Community based, Organizational Behavior and Human Resource Management, Community based research, Sociology and Political Science, business.industry, Strategy and Management, Field (Bourdieu), 05 social sciences, Peacebuilding, 050401 social sciences methods, Participatory action research, Public relations, 0506 political science, 0504 sociology, Political science, Conflict resolution, 050602 political science & public administration, Action research, business
Abstract

Participatory action research fits well with conflict resolution and peacebuilding; it is used by scholar-practitioners as part of field-based practice efforts that contribute to transforming conflict and add to scholarly knowledge. However, as Cynthia Chataway’s analysis of a participatory action research project undertaken with the Mohawk community of Kahnawake indicated, there are considerable constraints on mutual inquiry when it occurs in settings marked by historical oppression, distrust of outsiders and internal division; these constraints require the model to respond to the community context. Drawing on this insight, this paper explores a recent collaborative, community-based research that was part of a larger youth-centered peacebuilding and security initiative in Haiti. The initiative involved partners from Canada supporting a non-governmental organization and youth in four communities to engage in action research, under the umbrella of community-based research, as part of the 26-month project. The article draws out insights on ways in which the community-based research approach adapted to the conflict context, and reflects on the ways in which this form of engaged scholarship adds to knowledge in conflict resolution and peacebuilding.

Published
2020
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46. Quality of life impact of hypoglossal nerve stimulation with inspire (R) device in patients with obstructive sleep apnea intolerant to continuous positive airway pressure therapy

Author

Baptista-Jardín, P. (Peter Michael), Di Frisco, I. (Isberling Madeleine), Urrestarazu-Bolumburu, E. (Elena), Alcalde-Navarrete, J. (Juan Manuel), Alegre-Esteban, M. (Manuel), Sánchez, I. (Isabel), O'Connor-Reina, C. (Carlos), and Plaza, G. (Guillermo)

Subjects
Quality of life, Hypoglossal nerve stimulation, Área de Medicina Clínica y Epidemiología, Obstructive sleep apnea, Minimally invasive surgical technique, EuroQol-5D-5L
Abstract

Patients with obstructive sleep apnea (OSA) that do not tolerate/accept continuous positive airway pressure (CPAP) are candidates for surgical alternatives. Hypoglossal nerve stimulation (HNS) through the implantation of the Inspire (R) device constitutes a minimally invasive operative option. The main objective of this study is to estimate, under real-world clinical practice conditions, the 3-month impact on the quality of life (IQoL) of the HNS in patients with moderate/severe OSA who do not tolerate or accept CPAP, compared to patients who did not receive HNS. As a baseline, the unadjusted EuroQol utility index was 0.764 (SD:0.190) in the intervention group (IGr) and 0.733 (SD:0.205) in the control group (CGr); three months later, the indexes were 0.935 (SD: 0.101) and 0.727 (SD:0.200), respectively. The positive impact on quality of life was estimated to be +0.177 (95% CI: 0.044-0.310; p = 0.010). All dimensions in the IGr improved compared to CGr, especially for usual activities (p < 0.001) and anxiety/depression (p > 0.001). At the end of the follow-up, there was no significant difference in the quality of life between the general Spanish population and the IGr (difference: 0.012; CI95%: -0.03 to -0.057; p = 0.0578) for the same age range; however, there was a difference concerning the CGr (difference: -0.196; CI95%: -0.257 to -0.135; p < 0.001). In conclusion, patients with moderate/severe OSA implanted with the Inspire (R) device showed a positive IQoL.

Published
2022

47. Optimizing Mandibular Advancement Maneuvers during Sleep Endoscopy with a Titratable Positioner: DISE-SAM Protocol

Author

Fernandez-Sanjuan P, Arrieta J, Sanabria J, Alcaraz M, Bosco G, Perez-Martin N, Perez A, Carrasco-Llatas M, Moreno-Hay I, Rios-Lago M, Lugo R, O'Connor-Reina C, Baptista P, and Plaza G

Abstract

Mandibular advancement devices (MAD) are an effective alternative treatment to CPAP. Different maneuvers were performed during drug sleep-induced endoscopy (DISE) to mimic the effect of MAD. Using the Selector Avance Mandibular (SAM) device, we aimed to identify MAD candidates during DISE using a titratable, reproducible, and measurable maneuver. This DISE-SAM protocol may help to find the relationship between the severity of the respiratory disorder and the degree of response and determine the advancement required to improve the collapsibility of the upper airway. Explorations were performed in 161 patients (132 males; 29 females) with a mean age of 46.81 (SD = 11.42) years, BMI of 27.90 (SD = 4.19) kg/m(2), and a mean AHI of 26.51 (SD = 21.23). The results showed no relationship between severity and MAD recommendation. Furthermore, there was a weak positive relationship between the advancement required to obtain a response and the disease severity. Using the DISE-SAM protocol, the response and the range of mandibular protrusion were assessed, avoiding the interexaminer bias of the jaw thrust maneuver. We suggest prescribing MAD as a single, alternative, or multiple treatment approaches following the SAM recommendations in a personalized design.

Published
2022

48. COMPASS criteria applied to a contemporary cohort of unselected patients with stable coronary artery diseases: Insights from the STARTregistry

Author

De Luca L., Formigli D., Meessen J., Uguccioni M., Cosentino N., Paolillo C., Di Lenarda A., Colivicchi F., Gabrielli D., Gulizia M. M., Scherillo M., Maras P., Ramani F., Falcone C., Passarelli I., Mauri S., Calabro P., Bianchi R., Di Palma G., Mascia F., Vetrano A., Fusco A., Proia E., Aiello A., Tomai F., Licitra R., Petrolini A., Bosco B., Magliari F., Callerame M., Mazzella T., Lettica G. V., Coco G., Incao F., Marinacci L., D'Addario S., Tartaglione S. N., Ubaldi S., Sanchez F. A., Costa P., Manca G., Failla M., Procaccini V., Senni M., Luminita E. M., Bonomo P., Mossa C., Corda S., Colavita A. R., Trevisonno G., Vizzari G., Formaro C., Nalin I. L., De Rosa F. M., Fontana F., Fuscaldo G. F., Passamonti E., Bertella E., Calvaruso E. V., Varani E., Tani F., Cicchitelli G., Paoloni P., Marziali A., Campo G., Tebaldi M., Biscaglia S., Di Biase M., Brunetti N. D., Gallotta A. M., Mattei L., Marini R., Balsemin F., D'Urbano M., Naio R., Vicinelli P., Arena G., Mazzini M., Gigli N., Miserrafiti B., Monopoli A., Mortara A., Delfino P., Chioffi M. M., Marino P., Gravellone M., Barbieri L., Ledda A., Geraci G., Carmina M. G., Raisaro A. E., Di Giacomo C., Somaschini A., Fasano M. L., Sannazzaro M., Arcieri R., Pantaleoni M., Leuzzi C., Gorlato G., Greco G., Chiera A., Ammaturo T. A., Malanchini G., Del Corral M. P., Tedesco L., Pede S., Urso L. G., Piscione F., Galasso G., Provasoli S., Fattore L., Lucca G., Cresti A., Cardillo A., Fera M. S., Vennettilli F., Gaudio C., Paravati V., Caldarola P., Locuratolo N., Verlato R., De Conti F., Turiano G., Preti G., Moretti L., Silenzi S., Colonna G., Picciolo A., Nicosia A., Cascone C., Di Sciascio G., Mangiacapra F., Russo A., Mastroianno S., Esposito G., Cosmi F., D'Orazio S., Costantini C., Lanari A., De Rosa P., Esposito L., Bilato C., Dalla Valle C., Ceresa M., Colombo E., Pennisi V., Casciola G., Driussi M., Bisceglia T., Scalvini S., Rivadossi F., Volpe M., Comito F., Scorzoni D., Grimoldi P., Lagioia R., Santoro D., De Cesare N., Comotti T., Poli A., Martina P., Musolino M. F., Multari E. I., Bilardo G., Scalchi G., Olivieri C., Caranci F., Pavan D., Ganci G., Mariani A., Falchetti E., Lanzillo T., Caccavale A., Bongo A. S., Rizzi A., Favilli R., Maffei S., Mallardo M., Fulgione C., Bordin F., Bonmassari R., Battaia E., Puzzo A., Vianello G., D'Arpino A., Romei M., Pajes G., Petronzelli S., Ghezzi F., Brigido S., Pignatelli L., Brscic E., Sori P., Russo M., Biancolillo E., Ignone G., De Giorgio N. A., Campaniello C., Ponticelli P., Margonato A., Gerosa S., Cutaia A., Casalicchio C., Bartolomucci F., Larosa C., Spadafina T., Putignano A., Se Cristofaro R., Bernardi L., Sommariva L., Celestini A., Bertucci C. M., Marchetti M., Franceschini Grisolia E., Ammendolea C., Carini M., Scipione P., Politano M., Rubino G., Reina C., Peccerillo N., Paloscia L., D'Alleva A., Petacchi R., Pignalosa M., Lucchetti D., Di Palma F., La Mastra R. A., Amico A. F., De Filippis M., Fontanella B., Zanini G., Casolo G., Del Meglio J., Parato V. M., Genovesi E., D'Alimonte A., Miglioranza A., Alessandri N., Moscariello F., Mauro C., Sasso A., Caso P., Petrillo C., Napoletano C., Paparoni S. R., Bernardo V., Serdoz R., Rotunno R., Oppo I., Aloisio A., Aurelio A., Licciardello G., Cassaniti L., Francese G. M., Marcassa C., Temporelli P. L., Villani R., Zorzoli F., Mileto F., De Vecchis M., Scolozzi D., Lupi G., Caruso D., Rebulla E., La Fata B., Anselmi M., Girardi P., Borruso E., Ferrantelli G., Sassone B., Bressan S., Capriolo M., Pelissero E., Piancastelli M., Gobbi M., Cocco F., Bruno M. G., Berti S., Lo Surdo G., Tanzi P., De Rosa R., Vilei E., De Iaco M. R., Grassi G., Zanella C., Marullo L., Alfano G., Pelaggi P., Talarico R., Tuccillo B., Irace L., Proietti F., Di Croce G., Di Lorenzo L., Zarrilli A., Bongini M., Ranise A., Aprile A., Fornengo C., Capogrosso V., Tranghese A., Golia B., Marziano A., Roncon L., Picariello C., Bagni E., Leci E., Gregorio G., Gatto F., Piemonte F., Gervasio F., Navazio A., Guerri E., Belmonte E., Marino F., Di Belardino N., Di Nuzzo M. R., Epifani M., Comolatti G., Conconi B., Benea D., Casu G., Merella P., Ammirati M. A., Corrado V. M., Spagnolo D., Caico S. I., Bonizzato S., Margheri M., Corrado L., Antonicelli R., Ferrigno C., Merlino A., Nassiacos D., Antonelli A., Marchese A., Villella A., Bechi S., Lo Bianco F., Bedogni F., Negro L., Donato L., Statile D., Cassin M., Fedele F., Granatelli A., Calcagno S., Politi A., Pani A., De Luca, L, Formigli, D, Meessen, J, Uguccioni, M, Cosentino, N, Paolillo, C, Di Lenarda, A, Colivicchi, F, Gabrielli, D, Gulizia, M, Scherillo, M, Maras, P, Ramani, F, Falcone, C, Passarelli, I, Mauri, S, Calabro, P, Bianchi, R, Di Palma, G, Mascia, F, Vetrano, A, Fusco, A, Proia, E, Aiello, A, Tomai, F, Licitra, R, Petrolini, A, Bosco, B, Magliari, F, Callerame, M, Mazzella, T, Lettica, G, Coco, G, Incao, F, Marinacci, L, D'Addario, S, Tartaglione, S, Ubaldi, S, Sanchez, F, Costa, P, Manca, G, Failla, M, Procaccini, V, Senni, M, Luminita, E, Bonomo, P, Mossa, C, Corda, S, Colavita, A, Trevisonno, G, Vizzari, G, Formaro, C, Nalin, I, De Rosa, F, Fontana, F, Fuscaldo, G, Passamonti, E, Bertella, E, Calvaruso, E, Varani, E, Tani, F, Cicchitelli, G, Paoloni, P, Marziali, A, Campo, G, Tebaldi, M, Biscaglia, S, Di Biase, M, Brunetti, N, Gallotta, A, Mattei, L, Marini, R, Balsemin, F, D'Urbano, M, Naio, R, Vicinelli, P, Arena, G, Mazzini, M, Gigli, N, Miserrafiti, B, Monopoli, A, Mortara, A, Delfino, P, Chioffi, M, Marino, P, Gravellone, M, Barbieri, L, Ledda, A, Geraci, G, Carmina, M, Raisaro, A, Di Giacomo, C, Somaschini, A, Fasano, M, Sannazzaro, M, Arcieri, R, Pantaleoni, M, Leuzzi, C, Gorlato, G, Greco, G, Chiera, A, Ammaturo, T, Malanchini, G, Del Corral, M, Tedesco, L, Pede, S, Urso, L, Piscione, F, Galasso, G, Provasoli, S, Fattore, L, Lucca, G, Cresti, A, Cardillo, A, Fera, M, Vennettilli, F, Gaudio, C, Paravati, V, Caldarola, P, Locuratolo, N, Verlato, R, De Conti, F, Turiano, G, Preti, G, Moretti, L, Silenzi, S, Colonna, G, Picciolo, A, Nicosia, A, Cascone, C, Di Sciascio, G, Mangiacapra, F, Russo, A, Mastroianno, S, Esposito, G, Cosmi, F, D'Orazio, S, Costantini, C, Lanari, A, De Rosa, P, Esposito, L, Bilato, C, Dalla Valle, C, Ceresa, M, Colombo, E, Pennisi, V, Casciola, G, Driussi, M, Bisceglia, T, Scalvini, S, Rivadossi, F, Volpe, M, Comito, F, Scorzoni, D, Grimoldi, P, Lagioia, R, Santoro, D, De Cesare, N, Comotti, T, Poli, A, Martina, P, Musolino, M, Multari, E, Bilardo, G, Scalchi, G, Olivieri, C, Caranci, F, Pavan, D, Ganci, G, Mariani, A, Falchetti, E, Lanzillo, T, Caccavale, A, Bongo, A, Rizzi, A, Favilli, R, Maffei, S, Mallardo, M, Fulgione, C, Bordin, F, Bonmassari, R, Battaia, E, Puzzo, A, Vianello, G, D'Arpino, A, Romei, M, Pajes, G, Petronzelli, S, Ghezzi, F, Brigido, S, Pignatelli, L, Brscic, E, Sori, P, Russo, M, Biancolillo, E, Ignone, G, De Giorgio, N, Campaniello, C, Ponticelli, P, Margonato, A, Gerosa, S, Cutaia, A, Casalicchio, C, Bartolomucci, F, Larosa, C, Spadafina, T, Putignano, A, Se Cristofaro, R, Bernardi, L, Sommariva, L, Celestini, A, Bertucci, C, Marchetti, M, Franceschini Grisolia, E, Ammendolea, C, Carini, M, Scipione, P, Politano, M, Rubino, G, Reina, C, Peccerillo, N, Paloscia, L, D'Alleva, A, Petacchi, R, Pignalosa, M, Lucchetti, D, Di Palma, F, La Mastra, R, Amico, A, De Filippis, M, Fontanella, B, Zanini, G, Casolo, G, Del Meglio, J, Parato, V, Genovesi, E, D'Alimonte, A, Miglioranza, A, Alessandri, N, Moscariello, F, Mauro, C, Sasso, A, Caso, P, Petrillo, C, Napoletano, C, Paparoni, S, Bernardo, V, Serdoz, R, Rotunno, R, Oppo, I, Aloisio, A, Aurelio, A, Licciardello, G, Cassaniti, L, Francese, G, Marcassa, C, Temporelli, P, Villani, R, Zorzoli, F, Mileto, F, De Vecchis, M, Scolozzi, D, Lupi, G, Caruso, D, Rebulla, E, La Fata, B, Anselmi, M, Girardi, P, Borruso, E, Ferrantelli, G, Sassone, B, Bressan, S, Capriolo, M, Pelissero, E, Piancastelli, M, Gobbi, M, Cocco, F, Bruno, M, Berti, S, Lo Surdo, G, Tanzi, P, De Rosa, R, Vilei, E, De Iaco, M, Grassi, G, Zanella, C, Marullo, L, Alfano, G, Pelaggi, P, Talarico, R, Tuccillo, B, Irace, L, Proietti, F, Di Croce, G, Di Lorenzo, L, Zarrilli, A, Bongini, M, Ranise, A, Aprile, A, Fornengo, C, Capogrosso, V, Tranghese, A, Golia, B, Marziano, A, Roncon, L, Picariello, C, Bagni, E, Leci, E, Gregorio, G, Gatto, F, Piemonte, F, Gervasio, F, Navazio, A, Guerri, E, Belmonte, E, Marino, F, Di Belardino, N, Di Nuzzo, M, Epifani, M, Comolatti, G, Conconi, B, Benea, D, Casu, G, Merella, P, Ammirati, M, Corrado, V, Spagnolo, D, Caico, S, Bonizzato, S, Margheri, M, Corrado, L, Antonicelli, R, Ferrigno, C, Merlino, A, Nassiacos, D, Antonelli, A, Marchese, A, Villella, A, Bechi, S, Lo Bianco, F, Bedogni, F, Negro, L, Donato, L, Statile, D, Cassin, M, Fedele, F, Granatelli, A, Calcagno, S, Politi, A, and Pani, A

Subjects
medicine.medical_specialty, animal structures, Population, Myocardial Infarction, Coronary artery disease, Rivaroxaban, Internal medicine, Epidemiology, medicine, Humans, Registries, Myocardial infarction, education, Stroke, education.field_of_study, Aspirin, business.industry, Health Policy, Incidence (epidemiology), medicine.disease, COMPASS trial, Cohort, Cardiology and Cardiovascular Medicine, business, START registry, Mace
Abstract

Aims Recently, the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial demonstrated that dual therapy reduced cardiovascular outcomes compared with aspirin alone in patients with stable atherosclerotic disease. Methods and results We sought to assess the proportion of patients eligible for the COMPASS trial and to compare the epidemiology and outcome of these patients with those without COMPASS inclusion or with any exclusion criteria in a contemporary, nationwide cohort of patients with stable coronary artery disease. Among the 4068 patients with detailed information allowing evaluation of eligibility, 1416 (34.8%) did not fulfil the inclusion criteria (COMPASS-Not-Included), 841 (20.7%) had exclusion criteria (COMPASS-Excluded), and the remaining 1811 (44.5%) were classified as COMPASS-Like. At 1 year, the incidence of major adverse cardiovascular event (MACE), a composite of cardiovascular death, myocardial infarction, and stroke, was 0.9% in the COMPASS-Not-Included and 2.0% in the COMPASS-Like (P = 0.01), and 5.0% in the COMPASS-Excluded group (P Conclusion In a contemporary real-world cohort registry of stable coronary artery disease, most patients resulted as eligible for the COMPASS. These patients presented a considerable annual risk of MACE that consistently increases in the presence of multiple risk factors.

Published
2021

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