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15. Model tests on discontinuities in subsurface barrier installed by the vibrating beam method

Author

Wu, W., Aschauer, F., and Reiser, G.

Subjects
Clay -- Mechanical properties, Silt -- Mechanical properties, Water, Underground -- Composition, Water pollution -- United States, Water pollution -- Control, Vibration tests -- Methods, Dynamic testing -- Methods, Earth sciences, Engineering and manufacturing industries, Science and technology
Abstract

In the present note, the susceptibility to necking of a subsurface barrier installed by the vibrating beam method in fine-grained soils is investigated by physical model tests. Two soils are investigated, a clayey soil and a silty soil. The model soil is prepared by moist tamping. The recipe of slurry in the model tests is widely used in the foundation engineering industry. The dynamic loading exerted by the vibration of the adjacent panel is simulated by a shake table. The test results show that soil plasticity and water content are the major influence factors on the susceptibility to necking. The plasticity index can be used as an indicator for the susceptibility to necking of subsurface barrier installed by the vibrating beam method in fine-grained soils. Other influence factors on necking are also investigated and their implications for practice are discussed. CE Database subject headings: Fine-grained soil; Model tests: Barriers; Clays; Silts; Ground-water pollution.

Published
2008

47. Новый синтетический пептид защищает нейроны от гибели, вызванной токсическим воздействием активированных тучных клеток, через рецептор, активируемый протеазами

Author

Бабкина, И. И., primary, Струкова, С. М., additional, Пинелис, В. Г., additional, Райзер, Г., additional, Горбачева, Л. Р., additional, Babkina, I. I., additional, Strukova, S. M., additional, Pinelis, V. G., additional, Reiser, G., additional, and Gorbacheva, L. R., additional

Published
2016
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48. Subtype specific internalization of P2Y1 and P2Y2 receptors induced by novel adenosine 5′-O-(1-boranotriphosphate) derivatives

Author

Tulapurkar, M E, Laubinger, W, Nahum, V, Fischer, B, and Reiser, G

Subjects
Purinergic P2 Receptor Agonists, Arachidonic Acid, DNA, Complementary, Microscopy, Confocal, Green Fluorescent Proteins, Molecular Conformation, Stereoisomerism, Transfection, Endocytosis, Recombinant Proteins, Cell Line, Receptors, Purinergic P2Y2, Receptors, Purinergic P2Y1, Structure-Activity Relationship, Adenosine Triphosphate, Isotope Labeling, Papers, Humans, Calcium
Abstract

P2Y-nucleotide receptors represent important targets for drug development. The lack of stable and receptor specific agonists, however, has prevented successful therapeutic applications. A novel series of P-boronated ATP derivatives (ATP-alpha-B) were synthesized by substitution of a nonbridging O at P(alpha) with a BH(3) group. This introduces a chiral center, thus resulting in diastereoisomers. In addition, at C2 of the adenine ring a further substitution was made (Cl- or methylthio-). The pairs of diastereoisomers were denoted here as A and B isomers. Here, we tested the receptor subtype specificity of these analogs on HEK 293 cells stably expressing rat P2Y(1) and rat P2Y(2) receptors, respectively, both attached to the fluorescent marker protein GFP (rP2Y(1)-GFP, rP2Y(2)-GFP). We investigated agonist-induced receptor endocytosis, [Ca(2+)](i) rise and arachidonic acid (AA) release. Agonist-induced endocytosis of rP2Y(1)-GFP was more pronounced for the A isomers than the corresponding B counterparts for all ATP-alpha-B analogs. Both 2-MeS-substituted diastereoisomers induced a greater degree of agonist-induced receptor endocytosis as compared to the 2-Cl-substituted derivatives. Endocytosis results are in accordance with the potency to induce Ca(2+) release by these compounds in HEK 293 cells stably transfected with rP2Y(1). In case of rP2Y(2)-GFP, the borano-nucleotides were very weak agonists in comparison to UTP and ATP in terms of Ca(2+) release, AA release and in inducing receptor endocytosis. The different ATP-alpha-B derivatives and also the diastereoisomers were equally ineffective. Thus, the new agonists may be considered as potent and highly specific agonist drug candidates for P2Y(1) receptors. The difference in activity of the ATP analogs at P2Y receptors could be used as a tool to investigate structural differences between P2Y receptor subtypes.

Published
2004

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