99 results on '"Reiss, I.K.M. (Irwin)"'
Search Results
2. Assessing knowledge and skills of maternity care professionals regarding neonatal hyperbilirubinaemia: a nationwide survey
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van der Geest, B.A.M. (Berthe A. M.), Theeuwen, I.M. (Imke M.), Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), Been, J.V. (Jasper V.), van der Geest, B.A.M. (Berthe A. M.), Theeuwen, I.M. (Imke M.), Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), and Been, J.V. (Jasper V.)
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Background: Neonatal hyperbilirubinaemia is a physiologic phenomenon, but, when severe, may cause lifelong disability. Maternity care assistants (MCAs) play an important role in timely recognition of severe neonatal jaundice. We assessed knowledge and skills of MCAs regarding neonatal hyperbilirubinaemia. Methods: All Dutch MCAs (n = 9065) were invited to fill out a questionnaire assessing knowledge, expertise, and handling of neonatal jaundice. Additionally, we developed an e-learning and provided training sessions to a subgroup of MCAs (n = 99), and assessed their knowledge on neonatal hyperbilirubinaemia before and after the training. Results: One thousand four hundred sixty-five unique online questionnaires were completed (response 16.2%). The median number of correctly answered knowledge questions was 5 (out of six; IQR 1). Knowledge was significantly better when respondents had had in-service training on neonatal hyperbilirubinaemia in the previous year (p = 0.024). Although 82% of respondents felt highly skilled or skilled to assess jaundice, accuracy of estimation of total serum bilirubin levels by assessing skin colour was generally poor and prone to underestimation. Among participants attending a training session, those who completed the e-learning beforehand had higher pre-training scores (5 (IQR 1) vs. 4 (IQR 2); p < 0.001). The median post-training score was higher than pre-training (6 (IQR 1) vs. 5 (IQR 2); p < 0.001). Conclusions: Background
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- 2021
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3. Study protocol: a core outcome set for perinatal interventions for congenital diaphragmatic hernia
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Vergote, S. (Simen), De Bie, F. (Felix), Bosteels, J. (Jan), Hedrick, H. (Holly), Duffy, J. (James), Power, B. (Beverley), Benachi, A. (Alexandra), Coppi, P. (Paolo) de, Fernandes, C.J. (Caraciolo), Lally, K.P. (Kevin), Reiss, I.K.M. (Irwin), Deprest, J., Vergote, S. (Simen), De Bie, F. (Felix), Bosteels, J. (Jan), Hedrick, H. (Holly), Duffy, J. (James), Power, B. (Beverley), Benachi, A. (Alexandra), Coppi, P. (Paolo) de, Fernandes, C.J. (Caraciolo), Lally, K.P. (Kevin), Reiss, I.K.M. (Irwin), and Deprest, J.
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Background: Congenital diaphragmatic hernia (CDH) is, depending of the severity, a birth defect associated with significant mortality and morbidity. Prenatal screening by ultrasound may detect this condition and comprehensive assessment of severity is possible, allowing for in utero referral to an experienced centre for planned delivery. In an effort to improve outcomes, prenatal interventions to stimulate lung development were proposed. Along the same lines, new postnatal management strategies are being developed. In order to enable proper comparison of novel perinatal interventions as well as outcomes, a set of uniform and relevant outcome measures is required. Core outcome sets (COS) are agreed, clearly defined sets of outcomes to be measured in a standardised manner and reported consistently. Herein we aim to describe the methodology we will use to define a COS for perinatal and neonatal outcomes of foetuses and newborns with congenital diaphragmatic hernia and to draft a dissemination and implementation plan. Methods: We will use the methodology described in the Core Outcome Measures in Effectiveness Trials (COMET) Initiative Handbook. An international steering group will be created to guide the development of the COS. We are systematically reviewing the literature to identify all potential relevant pre- and neonatal outcomes previously used in studies on perinatal interventions for CDH. We will build a consensus on these core outcomes in a stakeholder group using the Delphi method. After completion, a stakeholder meeting will decide on a final COS, using a modified Nominal Group Technique. Thereafter, we will review potential definitions and measurements of these outcomes, and again a consensus meeting will be organised, to finalise the COS before dissemination. Discussion: We have started a procedure to develop a COS for studies on perinatal interventions for congenital diaphragmatic hernia, with the purpose of improving the quality of research, guide clinica
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- 2021
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4. Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates
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Kurul, Ş. (Şerife), Simons, S.H.P. (Sinno H. P.), Ramakers, C.R.B., Rijke, Y.B. (Yolanda) de, Kornelisse, R.F. (René), Reiss, I.K.M. (Irwin), Taal, H.R. (H. Rob), Kurul, Ş. (Şerife), Simons, S.H.P. (Sinno H. P.), Ramakers, C.R.B., Rijke, Y.B. (Yolanda) de, Kornelisse, R.F. (René), Reiss, I.K.M. (Irwin), and Taal, H.R. (H. Rob)
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Background: Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), procalcitonin (PCT) and CRP with subsequent sepsis severity and mortality in preterm infants suspected of late onset neonatal sepsis. Methods: The study was conducted at the Erasmus University Medical Center–Sophia Children’s Hospital Rotterdam. Patient data from January 2018 until October 2019 were reviewed for all preterm neonates born with a gestational age below 32 weeks with signs and symptoms suggestive of systemic infection, in whom blood was taken for blood culture and for inflammatory biomarkers determinations. Plasma IL-6 and PCT were assessed next to CRP at the moment of suspicion. We assessed the association with 7-day mortality and sepsis severity (neonatal sequential organ failure assessment (nSOFA) score, need for inotropic support, invasive ventilation and thrombocytopenia). Results: A total of 480 suspected late onset neonatal sepsis episodes in 208 preterm neonates (gestational age < 32 weeks) were retrospectively analyzed, of which 143 episodes were classified as sepsis (29.8%), with 56 (11.7%) cases of culture negative, 63 (13.1%) cases of gram-positive and 24(5.0%) cases of gram-negative sepsis. A total of 24 (5.0%) sepsis episodes resulted in death within 7 days after suspicion of LONS. Both IL-6 (adjusted hazard ratio (aHR): 2.28; 95% CI 1.64–3.16; p < 0.001) and PCT (aHR: 2.91; 95% CI 1.70–5.00; p < 0.001) levels were associated with 7-day mortality; however, CRP levels were not significantly correlated with 7-day mortality (aHR: 1.16; 95% CI (0.68–2.00; p = 0.56). Log IL-6, log PCT and log CRP levels were all significantly correlated with the need for inotropic support. Conclusions: Our findings show that serum IL-6 and PCT level
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- 2021
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5. Early weight gain trajectories and body composition in infancy in infants born very preterm
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Beunders, V.A.A. (Victoria), Roelants, J.A. (Jorine), Hulst, J.M. (Jessie), Rizopoulos, D. (Dimitris), Hokken-Koelega, A.C.S. (Anita), Neelis, E.G. (Esther), Fluiter, K.S. (Kirsten) de, Jaddoe, V.W.V. (Vincent), Reiss, I.K.M. (Irwin), Joosten, K.F.M. (Koen), Vermeulen, M.J. (Marijn), Beunders, V.A.A. (Victoria), Roelants, J.A. (Jorine), Hulst, J.M. (Jessie), Rizopoulos, D. (Dimitris), Hokken-Koelega, A.C.S. (Anita), Neelis, E.G. (Esther), Fluiter, K.S. (Kirsten) de, Jaddoe, V.W.V. (Vincent), Reiss, I.K.M. (Irwin), Joosten, K.F.M. (Koen), and Vermeulen, M.J. (Marijn)
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Background: Concerns are raised about the influence of rapid growth on excessive fat mass (FM) gain in early life and later cardiometabolic health of infants born preterm. Objectives: To study the association between postnatal weight gain trajectories and body composition in infancy in infants born very preterm. Methods: In infants born <30 weeks gestation, we evaluated associations between weight Z-score trajectories for three consecutive timeframes (NICU stay, level-II hospital stay and at home) and body composition, measured at 2 and 6 months corrected age by air-displacement plethysmography. Results: Of 120 infants included, median gestational age at birth was 27+5 (interquartile range 26+1;28+5) and birth weight 1015 g (801;1250). The majority of infants did not make up for their initial loss of weight Z-score, but growth and later body composition were within term reference values. Weight gain during NICU stay was not associated with fat mass (absolute, %FM or FM index) in infancy. Weight gain during NICU and level II hospital stay was weakly associated with higher absolute lean mass (LM), but not after adjustment for length (LM index). Weight gain in the level-II hospital was positively associated with fat mass parameters at 2 months but not at 6 months. Strongest associations were found between weight gain at home and body composition (at both time points), especially fat mass. Concl
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- 2020
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6. Use of Continuous Physiological Monitor Data to Evaluate Doxapram Therapy in Preterm Infants
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Poppe, J.A., Weteringen, W. (Willem) van, Völler, S., Willemsen, S.P. (Sten), Goos, T.G., Reiss, I.K.M. (Irwin), Simons, S.H.P. (Sinno), Poppe, J.A., Weteringen, W. (Willem) van, Völler, S., Willemsen, S.P. (Sten), Goos, T.G., Reiss, I.K.M. (Irwin), and Simons, S.H.P. (Sinno)
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Introduction: Evaluation of pharmacotherapy during intensive care treatment is commonly based on subjective, intermittent interpretations of physiological parameters. Realtime visualization and analysis may improve drug effect evaluation. We aimed to evaluate the effects of the respiratory stimulant doxapram objectively in preterm infants using continuous physiological parameters. Methods: In this longitudinal observational study, preterm infants who receive
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- 2020
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7. Parental psychological distress during pregnancy and the risk of childhood lower lung function and asthma: a population-based prospective cohort study
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van Meel, ER, Saharan, G., Jaddoe, V.W.V. (Vincent), Jongste, J.C. (Johan) de, Reiss, I.K.M. (Irwin), Tiemeier, H.W. (Henning), El Marroun, H. (Hanan), Duijts, L. (Liesbeth), van Meel, ER, Saharan, G., Jaddoe, V.W.V. (Vincent), Jongste, J.C. (Johan) de, Reiss, I.K.M. (Irwin), Tiemeier, H.W. (Henning), El Marroun, H. (Hanan), and Duijts, L. (Liesbeth)
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Background Although maternal psychological distress during pregnancy is associated with increased risks of respiratory morbidity in preschool children, it is unknown whether this association persists into later childhood. Objective To examine the association between parental psychological distress during pregnancy and lung function and asthma in children of school age. Methods This study of 4231 children was embedded in a population-based prospective cohort. Parental psychological distress was assessed by the Brief Symptom Inventory during and 3 years after pregnancy, and in mothers also at 2 and 6 months after pregnancy. At age 10 years, lung function was obtained by spirometry and asthma by questionnaire. Results The prevalence of asthma was 5.9%. Maternal overall psychological distress during pregnancy was associated with a lower forced vital capacity (FVC) (z-score difference −0.10 (95% CI −0.20 to –0.01) per 1-unit increase), maternal depressive symptoms during pregnancy with a lower forced expiratory volume in the first second (FEV1 ) and FVC (−0.13 (95% CI −0.24 to –0.01) and −0.13 (95% CI −0.24 to –0.02) when using clinical cut-offs) in their children. All maternal psychological distress measures during pregnancy were associated with an increased risk of asthma (range OR: 1.46 (95% CI 1.12 to 1.90) to 1.91 (95% CI 1.26 to 2.91)). Additional adjustment for paternal psychological distress during pregnancy and parental psychological distress after pregnancy did not materially change the associations. Paternal psychological distress during pregnancy was not associated with childhood respiratory morbidity. Conclusion Maternal, but not paternal, psychological distress during pregnancy is associated with an increased risk of asthma and partly lower lung function in children. This suggests intrauterine programming for the risk of later-life respiratory
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- 2020
8. Parental psychological distress during pregnancy and the risk of childhood lower lung function and asthma: a population-based prospective cohort study
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van Meel, E.R., Saharan, G., Jaddoe, V.W.V. (Vincent), Jongste, J.C. (Johan) de, Reiss, I.K.M. (Irwin), Tiemeier, H.W. (Henning), El Marroun, H. (Hanan), Duijts, L. (Liesbeth), van Meel, E.R., Saharan, G., Jaddoe, V.W.V. (Vincent), Jongste, J.C. (Johan) de, Reiss, I.K.M. (Irwin), Tiemeier, H.W. (Henning), El Marroun, H. (Hanan), and Duijts, L. (Liesbeth)
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Background Although maternal psychological distress during pregnancy is associated with increased risks of respiratory morbidity in preschool children, it is unknown whether this association persists into later childhood. Objective To examine the association between parental psychological distress during pregnancy and lung function and asthma in children of school age. Methods This study of 4231 children was embedded in a population-based prospective cohort. Parental psychological distress was assessed by the Brief Symptom Inventory during and 3 years after pregnancy, and in mothers also at 2 and 6 months after pregnancy. At age 10 years, lung function was obtained by spirometry and asthma by questionnaire. Results The prevalence of asthma was 5.9%. Maternal overall psychological distress during pregnancy was associated with a lower forced vital capacity (FVC) (z-score difference −0.10 (95% CI −0.20 to –0.01) per 1-unit increase), maternal depressive symptoms during pregnancy with a lower forced expiratory volume in the first second (FEV1 ) and FVC (−0.13 (95% CI −0.24 to –0.01) and −0.13 (95% CI −0.24 to –0.02) when using clinical cut-offs) in their children. All maternal psychological distress measures during pregnancy were associated with an increased risk of asthma (range OR: 1.46 (95% CI 1.12 to 1.90) to 1.91 (95% CI 1.26 to 2.91)). Additional adjustment for paternal psychological distress during pregnancy and parental psychological distress after pregnancy did not materially change the associations. Paternal psychological distress during pregnancy was not associated with childhood respiratory morbidity. Conclusion Maternal, but not paternal, psychological distress during pregnancy is associated with an increased risk of asthma and partly lower lung function in children. This suggests intrauterine programming for the risk of later-life respiratory disease.
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- 2020
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9. Allogeneic cord blood transfusions for extremely preterm neonates: an extremely promising proof of concept
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Lopriore, E., Huisman, A. (Annemiek), Zwaginga, J.J. (Jaap), Snijder, P.M., Reiss, I.K.M. (Irwin), Stanworth, S, Lopriore, E., Huisman, A. (Annemiek), Zwaginga, J.J. (Jaap), Snijder, P.M., Reiss, I.K.M. (Irwin), and Stanworth, S
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- 2020
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10. Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review
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de Klerk, J.C.A., Engbers, A.G.J., Beek, F., Flint, R.B. (Robert), Reiss, I.K.M. (Irwin), Voller, S, Simons, S.H.P. (Sinno), de Klerk, J.C.A., Engbers, A.G.J., Beek, F., Flint, R.B. (Robert), Reiss, I.K.M. (Irwin), Voller, S, and Simons, S.H.P. (Sinno)
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The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and s
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- 2020
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11. Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
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Mensink-Bout, S.M., Voortman, R.G. (Trudy), Dervishaj, M., Reiss, I.K.M. (Irwin), Jongste, J.C. (Johan) de, Jaddoe, V.W.V. (Vincent), Duijts, L. (Liesbeth), Mensink-Bout, S.M., Voortman, R.G. (Trudy), Dervishaj, M., Reiss, I.K.M. (Irwin), Jongste, J.C. (Johan) de, Jaddoe, V.W.V. (Vincent), and Duijts, L. (Liesbeth)
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Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
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- 2020
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12. Hyperoxia in pediatric severe traumatic brain injury (TBI): a comparison of patient classification by cutoff versus cumulative (area-under-the-curve) analysis
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Ketharanathan, N., de Jonge, R.C.J., Klouwen, I., Wildschut, E.D. (Enno), Reiss, I.K.M. (Irwin), Tibboel, D. (Dick), Haitsma, I. (Iain), Buysse, C.M.P. (Corinne), Ketharanathan, N., de Jonge, R.C.J., Klouwen, I., Wildschut, E.D. (Enno), Reiss, I.K.M. (Irwin), Tibboel, D. (Dick), Haitsma, I. (Iain), and Buysse, C.M.P. (Corinne)
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Objective: Hyperoxia is associated with adverse outcome in severe traumatic brain injury (TBI). This study explored differences in patient classification of oxygen exposure by PaO2 cutoff and cumulative areaunder-the-curve (AUC) analysis. Methods: Retrospective, explorative study including children (<18 years) with accidental severe TBI (2002–2015). Oxygen exposure analysis used three PaO2 cutoff values and four PaO2 AUC categories during the first 24 hours of Pediatric Intensive Care Unit (PICU) admission. Results: Seventy-one patients were included (median age 8.9 years [IQR 4.6–12.9]), mortality 18.3% (n = 13). Patient hyperoxia classification differed depending on PaO2 cutoff vs AUC analysis: 52% vs. 26%, respectively, were classified in the highest hyperoxia category. Eleven patients (17%) classified as ‘intermediate oxygen exposure’ based on cumulative PaO2 analysis whereby they did not exceed the 200 mmHg PaO2 cutoff threshold. Patient classification variability was reflected by Pearson correlation coefficient of 0.40 (p-value 0.001). Conclusions: Hyperoxia classification in pediatric severe TBI during the first 24 hours of PICU admission differed depending on PaO2 cutoff or cumulative AUC analysis. We consider PaO2 cumulative (AUC) better approximates (patho-)physiological circumstances due to its time- and dose-dependent approach. Prospective studies exploring the association between cumulative PaO2, physiological parameters (e.g. ICP, PbtO2) and outcome are warranted as different patient classifications of oxygen exposure influences how its relationship to outcome is interpreted.
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- 2020
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13. Physiological-based cord clamping in very preterm infants — Randomised controlled trial on effectiveness of stabilisation
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Knol, R. (Ronny), Brouwer, E. (Emma), van den Akker, T. (Thomas), DeKoninck, P. (Philip), Geloven, N. (Nan) van, Polglase, G.R. (Graeme R.), Lopriore, E., Herkert, E. (Ellen), Reiss, I.K.M. (Irwin), Hooper, S.B. (Stuart B.), Te Pas, A.B. (Arjan B.), Knol, R. (Ronny), Brouwer, E. (Emma), van den Akker, T. (Thomas), DeKoninck, P. (Philip), Geloven, N. (Nan) van, Polglase, G.R. (Graeme R.), Lopriore, E., Herkert, E. (Ellen), Reiss, I.K.M. (Irwin), Hooper, S.B. (Stuart B.), and Te Pas, A.B. (Arjan B.)
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Aim: To test whether stabilising very preterm infants while performing physiological-based cord clamping (PBCC) is at least as effective as the standard approach of time-based delayed cord clamping (DCC). Methods: A randomised contro
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- 2020
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14. Circadian Variation in Human Milk Composition, a Systematic Review
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Italianer, M.F. (Merel F.), Naninck, E.F.G. (Eva F G), Roelants, J.A. (Jorine), Horst, G.T.J. (Gijsbertus) van der, Reiss, I.K.M. (Irwin), Goudoever, J.B.V. (Johannes B van), Joosten, K.F.M. (Koen), Chaves, I. (Ines), Vermeulen, M.J. (Marijn), Italianer, M.F. (Merel F.), Naninck, E.F.G. (Eva F G), Roelants, J.A. (Jorine), Horst, G.T.J. (Gijsbertus) van der, Reiss, I.K.M. (Irwin), Goudoever, J.B.V. (Johannes B van), Joosten, K.F.M. (Koen), Chaves, I. (Ines), and Vermeulen, M.J. (Marijn)
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BACKGROUND: Breastfeeding is considered the most optimal mode of feeding for neonates and mothers. Human milk changes over the course of lactation in order to perfectly suit the infant's nutritional and immunological needs. Its composition also varies throughout the day. Circadian fluctuations in some bioactive components are suggested to transfer chronobiological information from mother to child to assist the development of the biological clock. This review aims to give a complete overview of studies examining human milk components found to exhibit circadian variation in their concentration. METHODS: We included studies assessing the concentration of a specific human milk component more than once in 24 h. Study characteristics, including gestational age, lactational stage, sampling strategy, analytical method, and outcome were extracted. Methodological quality was graded using a modified Newcastle-Ottawa Scale (NOS). RESULTS: A total of 83 reports assessing the circadian variation in the concentration of 71 human milk components were included. Heterogeneity among studies was high. The methodological quality varied widely. Significant circadian variation is found in tryptophan, fats, triacylglycerol, cholesterol, iron, melatonin, cortisol, and cortisone. This may play a role in the child's growth and development in terms of the biological clock.
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- 2020
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15. Dynamic Light Scattering: A New Noninvasive Technology for Neonatal Heart Rate Monitoring
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Gangaram-Panday, N.H. (Norani H.), Van Essen, T. (Tanja), Goos, T.G. (Tom), Jonge, R.C.J. (Rogier) de, Reiss, I.K.M. (Irwin), Weteringen, W. (Willem) van, Gangaram-Panday, N.H. (Norani H.), Van Essen, T. (Tanja), Goos, T.G. (Tom), Jonge, R.C.J. (Rogier) de, Reiss, I.K.M. (Irwin), and Weteringen, W. (Willem) van
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Background: Heart rate (HR) detection in premature infants using electrocardiography (ECG) is challenging due to a low signal amplitude and the fragility of the premature skin. Recently, the dynamic light scattering (DLS) technique has been miniaturized, allowing noninvasive HR measurements with a single sensor. Objective: The aim was to determine the accuracy of DLS for HR measurement in infants, compared to ECG-derived HR. Methods: Stable infants with a gestational age of ≥26 weeks, monitored with ECG, were eligible for inclusion. HR was measured with the DLS sensor at 5 different sites for 15 min each. We recorded every 10th second of the DLS-derived HR and the DLS signal-to-noise ratio (SNR), and the ECG-derived HR was extracted for analysis. Patients were randomly divided into 2 groups. In the first group, the optimal SNR cut-off value was determined and then applied to the second group to assess agreement. Results: HR measurements from 31 infants were analyzed. ECG-DLS paired data points were collected at the forehead, an upper extremity, the thorax, a lower extremity, and the abdomen. When applying the international accuracy standard for HR detection, DLS accuracy in the first group (n = 15) was optimal at the forehead (SNR cut-off 1.66). Application of this cut-off to the second group (n = 16) showed good agreement between DLS-derived HR and ECG-derived HR (bias -0.73 bpm; 95% limits of agreement -15.46 and 14.00 bpm) at the forehead with approximately 80% (i.e., 1,066/1,310) of all data pairs remaining. Conclusion: The investigated DLS sensor was sensitive to movement, overall providing less accurate HR measurements than ECG and pulse oximetry. In this study population, specific measurement sites provided excellent signal quality and good agreement with ECG-derived HR.
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- 2020
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16. Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension
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Cai, Z.Y., Klein, T. (Theo), Geenen, L.W., Tu, L., Tian, S.Y., Bosch, A.E. (Annemien) van den, Rijke, Y.B. (Yolanda) de, Reiss, I.K.M. (Irwin), Boersma, H. (Eric), Duncker, D.J.G.M. (Dirk), Boomars, K.A.T. (Karin), Guignabert, C., Merkus, D. (Daphne), Cai, Z.Y., Klein, T. (Theo), Geenen, L.W., Tu, L., Tian, S.Y., Bosch, A.E. (Annemien) van den, Rijke, Y.B. (Yolanda) de, Reiss, I.K.M. (Irwin), Boersma, H. (Eric), Duncker, D.J.G.M. (Dirk), Boomars, K.A.T. (Karin), Guignabert, C., and Merkus, D. (Daphne)
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Exogenous melatonin has been reported to be beneficial in the treatment of pulmonary hypertension (PH) in animal models. Multiple mechanisms are involved, with melatonin exerting anti-oxidant and anti-inflammatory effects, as well as inducing vasodilation and cardio-protection. However, endogenous levels of melatonin in treatment-naïve patients with PH and their clinical significance are still unknown. Plasma levels of endogenous melatonin were measured by liquid chromatography-tandem mass spectrometry in PH patients (n=64, 43 pulmonary arterial hypertension (PAH) and 21 chronic thromboembolic PH (CTEPH)) and healthy controls (n = 111). Melatonin levels were higher in PH, PAH, and CTEPH patients when compared with controls (Median 118.7 (IQR 108.2–139.9), 118.9 (109.3–147.7), 118.3 (106.8–130.1) versus 108.0 (102.3–115.2) pM, respectively, p all <0.001). The mortality was 26% (11/43) in the PAH subgroup during a long-term follow-up of 42 (IQR: 32–58) months. Kaplan–Meier analysis showed that, in the PAH subgroup, patients with melatonin levels in the 1st quartile (<109.3 pM) had a worse survival than those in quartile 2–4 (Mean survival times were 46 (95% CI: 30–65) versus 68 (58–77) months, Log-rank, p = 0.026) with an increased hazard ratio of 3.5 (95% CI: 1.1–11.6, p = 0.038). Endogenous melatonin was increased in treatment-naïve patients with PH, and lower levels of melatonin were associated with worse long-term survival in patient with PAH.
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- 2020
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17. Associations of maternal age at the start of pregnancy with placental function throughout pregnancy: The Generation R Study
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Erkamp, J.S. (Jan), Jaddoe, V.W.V. (Vincent), Mulders, A.G.M.G.J. (Annemarie), Duijts, L. (Liesbeth), Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), Gaillard, R. (Romy), Erkamp, J.S. (Jan), Jaddoe, V.W.V. (Vincent), Mulders, A.G.M.G.J. (Annemarie), Duijts, L. (Liesbeth), Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), and Gaillard, R. (Romy)
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Objective: To examine the associations of maternal age at the start of pregnancy across the full range with second and third trimester uterine and umbilical artery flow indices, and placental weight. Study design: In a population-based prospective cohort study among 8271 pregnant women, we measured second and third trimester uterine artery resistance and umbilical artery pulsatility indices and the presence of third trimester uterine artery notching using Doppler ultrasound. Results: Compared to women aged 25−29.9 years, higher maternal age was associated with a higher third trimester uterine artery resistance index (difference for women 30−34.9 years was 0.10 SD (95% Confidence Interval (CI) 0.02 to 0.17), and for women aged ≥40 years 0.33 SD (95% CI 0.08 to 0.57), overall linear trend 0.02 SD (95% CI 0.01 to 0.03) per year). Compared to women aged 25−29.9 years, women younger than 20 years had an increased risk of third trimester uterine artery notching (Odds Ratio (OR) 1.97 (95% CI 1.30–3.00)). A linear trend was present with a decrease in risk of third trimester uterine artery notching per year increase in maternal age (OR 0.96 (95% CI 0.94 to 0.98)). Maternal age was not consistently associated with umbilical artery pulsatility indices or placental weight. Conclusions: Young maternal age is associated with higher risk of third trimester uterine artery notching, whereas advanced maternal age is associated with a higher third trimester uterine artery resistance index, which may predispose to an increased risk of pregnancy complications.
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- 2020
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18. No evidence of vertical transmission of SARS-CoV-2 after induction of labour in an immune-suppressed SARS-CoV-2-positive patient
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Grimminck, K., Santegoets, L.A.M. (Lindy), Siemens, F.C., Fraaij, P.L.A. (Pieter), Reiss, I.K.M. (Irwin), Schoenmakers, S. (Sam), Grimminck, K., Santegoets, L.A.M. (Lindy), Siemens, F.C., Fraaij, P.L.A. (Pieter), Reiss, I.K.M. (Irwin), and Schoenmakers, S. (Sam)
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We present a case of a 38+1 weeks pregnant patient (G1P0) with a proven COVID-19 infection, who was planned for induction of labour because of pre-existent hypertension, systemic lupus erythematosus, respiratory problem of coughing and mild dyspnoea without fever during the COVID-19 pandemic in March 2020. To estimate the risk of vertical transmission of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) during labour and delivery, we collected oropharyngeal, vaginal, urinary, placental and neonatal PCRs for SARSCoV-2 during the period of admission. All PCRs, except for the oropharyngeal, were negative and vertical transmission was not observed. Labour and delivery were uncomplicated and the patient and neonate were discharged the next day. We give a short overview of the known literature about SARS-CoV-2-related infection during pregnancy, delivery and outcome of the neonate.
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- 2020
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19. Associations of Maternal Early-Pregnancy Glucose Concentrations With Placental Hemodynamics, Blood Pressure, and Gestational Hypertensive Disorders
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Erkamp, J.S. (Jan), Geurtsen, M.L. (Madelon), Duijts, L. (Liesbeth), Reiss, I.K.M. (Irwin), Mulders, A.G.M.G.J. (Annemarie), Steegers, E.A.P. (Eric), Gaillard, R. (Romy), Jaddoe, V.W.V. (Vincent), Erkamp, J.S. (Jan), Geurtsen, M.L. (Madelon), Duijts, L. (Liesbeth), Reiss, I.K.M. (Irwin), Mulders, A.G.M.G.J. (Annemarie), Steegers, E.A.P. (Eric), Gaillard, R. (Romy), and Jaddoe, V.W.V. (Vincent)
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BACKGROUND: Gestational diabetes mellitus is associated with increased risks of gestational hypertension and preeclampsia. We hypothesized that high maternal glucose concentrations in early pregnancy are associated with adverse placental adaptations and subsequently altered uteroplacental hemodynamics during pregnancy, predisposing to an increased risk of gestational hypertensive disorders. METHODS: In a population-based prospective cohort study from early pregnancy onwards, among 6,078 pregnant women, maternal early-pregnancy non-fasting glucose concentrations were measured. Mid and late pregnancy uterine and umbilical artery resistance indices were assessed by Doppler ultrasound. Maternal blood pressure was measured in early, mid, and late pregnancy and the occurrence of gestational hypertensive disorders was assessed using hospital registries. RESULTS: Maternal early-pregnancy glucose concentrations were not associated with mid or late pregnancy placental hemodynamic markers. A 1 mmol/l increase in maternal early-pregnancy glucose concentrations was associated with 0.71 mm Hg (95% confidence interval 0.22-1.22) and 0.48 mm Hg (95% confidence interval 0.10-0.86) higher systolic and diastolic blood pressure in early pregnancy, respectively, but not with blood pressure in later pregnancy. Also, maternal glucose concentrations were not associated with the risks of gestational hypertension or preeclampsia. CONCLUSIONS: Maternal early-pregnancy non-fasting glucose concentrations within the normal range are associated with blood pressure in early pregnancy, but do not seem to affect placental hemodynamics and the risks of gestational hypertensive disorders.
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- 2020
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20. Chlamydia trachomatis during pregnancy and childhood asthma-related morbidity: a population-based prospective cohort
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Meel, E.R. (Evelien) van, Attanasi, M. (Marina), Jaddoe, V.W.V. (Vincent), Reiss, I.K.M. (Irwin), Moll, H.A. (Henriëtte), Jongste, J.C. (Johan) de, Duijts, L. (Liesbeth), Meel, E.R. (Evelien) van, Attanasi, M. (Marina), Jaddoe, V.W.V. (Vincent), Reiss, I.K.M. (Irwin), Moll, H.A. (Henriëtte), Jongste, J.C. (Johan) de, and Duijts, L. (Liesbeth)
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INTRODUCTION: Chlamydia trachomatis is the most commonly reported sexually transmitted disease and although infection during pregnancy is associated with neonatal complications, long-term respiratory consequences are unknown. We aimed to determine whether C. trachomatis infection during pregnancy is associated with asthma-related symptoms across childhood METHODS: This study among 2475 children and their mothers was embedded in a population-based prospective cohort study. Maternal urine samples were tested for C. trachomatis infection during pregnancy. Questionnaires provided information on childhood physician-attended lower respiratory tract infections and wheezing, and current asthma at age 10 years. Lung function was measured by spirometry at age 10 years. RESULTS: The prevalence of C. trachomatis infection during pregnancy was 3.2% (78 out of 2475). C. trachomatis infection during pregnancy was not associated with lower respiratory tract infections until age 6 years, but was associated with a higher odds of wheezing in children until age 10 years (OR 1.50 (95% CI 1.10-2.03)). C. trachomatis infection during pregnancy was associated with an increased odds of asthma (OR 2.29 (95% CI 1.02-5.13)), and with a lower forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow at 75% of forced vital capacity (z-score difference -0.28 (95% CI -0.52- -0.04) and -0.24 (95% CI -0.46- -0.01), respectively) in children at age 10 years. The observed associations were only partly explained by mode of delivery, gestational age at birth or birthweight. CONCLUSIONS: C. trachomatis infection during pregnancy is associated with increased odds of wheezing, asthma and impaired lung function. The causality of the observed associations and potential underlying mechanisms need to be explored.
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- 2020
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21. The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy
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Annink, K.V. (Kim V.), Vries, L.S. (Linda) de, Groenendaal, F. (Floris), Vijlbrief, D.C. (Daniel C.), Weeke, L.C. (Lauren C.), Roehr, C.C. (Charles C.), Leguin, M. (Maarten), Reiss, I.K.M. (Irwin), Govaert, P. (Paul), Benders, J. (Jos), Dudink, J. (Jeroen), Annink, K.V. (Kim V.), Vries, L.S. (Linda) de, Groenendaal, F. (Floris), Vijlbrief, D.C. (Daniel C.), Weeke, L.C. (Lauren C.), Roehr, C.C. (Charles C.), Leguin, M. (Maarten), Reiss, I.K.M. (Irwin), Govaert, P. (Paul), Benders, J. (Jos), and Dudink, J. (Jeroen)
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BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed. METHODS: (Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3-7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3-7 were related to adverse outcome in univariate and the CUS of day 3-7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II). RESULTS: Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5-4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7-4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89). CONCLUSION: This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.
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- 2020
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22. Population screening for gestational hypertensive disorders using maternal, fetal and placental characteristics
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Erkamp, J.S. (Jan), Jaddoe, V.W.V. (Vincent), Duijts, L. (Liesbeth), Reiss, I.K.M. (Irwin), Mulders, A.G.M.G.J. (Annemarie), Steegers, E.A.P. (Eric), Gaillard, R. (Romy), Erkamp, J.S. (Jan), Jaddoe, V.W.V. (Vincent), Duijts, L. (Liesbeth), Reiss, I.K.M. (Irwin), Mulders, A.G.M.G.J. (Annemarie), Steegers, E.A.P. (Eric), and Gaillard, R. (Romy)
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Objective: To determine screening performance of maternal, fetal and placental characteristics for selecting pregnancies at risk of gestational hypertension and preeclampsia in a low-risk multi-ethnic population. Method: In a prospective population-based cohort among 7124 pregnant women, we collected maternal characteristics including body mass index, ethnicity, parity, smoking and blood pressure in early-pregnancy. Fetal characteristics included second and third trimester estimated fetal weight and sex determined by ultrasound. Placental characteristics included first and second trimester placental growth factor concentrations and second and third trimester uterine artery resistance indices. Results: Maternal characteristics provided the best screening result for gestational hypertension (area-under-the-curve [AUC] 0.79 [95% Confidence interval {CI} 0.76-0.81]) with 40% sensitivity at 90% specificity. For preeclampsia, the maternal characteristics model led to a screening performance of AUC 0.74 (95% CI 0.70-0.78) with 33% sensitivity at 90% specificity. Addition of second and third trimester placental ultrasound characteristics only improved screening performance for preeclampsia (AUC 0.78 [95% CI 0.75-0.82], with 48% sensitivity at 90% specificity). Conclusion: Routinely measured maternal characteristics, known at the start of pregnancy, can be used in screening for pregnancies at risk of gestational hypertension or preeclampsia within a low-risk multi-ethnic population. Addition of combined second and third trimester placental ultrasound characteristics only improved screening for preeclampsia.
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- 2020
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23. Propofol in neonates causes a dose-dependent profound and protracted decrease in blood pressure
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Kort, E.H.M. (Ellen) de, Twisk, J.W.R. (Jos), van t Verlaat, E.P.G. (Ellen P. G.), Reiss, I.K.M. (Irwin), Simons, S.H.P. (Sinno), Weissenbruch, M.M. (Mirjam) van, Kort, E.H.M. (Ellen) de, Twisk, J.W.R. (Jos), van t Verlaat, E.P.G. (Ellen P. G.), Reiss, I.K.M. (Irwin), Simons, S.H.P. (Sinno), and Weissenbruch, M.M. (Mirjam) van
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Aim: To analyse the effects of different propofol starting doses as premedication for endotracheal intubation on blood pressure in neonates. Methods: Neonates who received propofol starting doses of 1.0 mg/kg (n = 30), 1.5 mg/kg (n = 23) or 2.0 mg/kg (n = 26) as part of a previously published dose-finding study were included in this analysis. Blood pressure in the 3 dosing groups was analysed in the first 60 minutes after start of propofol. Results: Blood pressure declined after the start of propofol in all 3 dosing groups and was not restored 60 minutes after the start of propofol. The decline in bl
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- 2020
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24. Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study
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Koopman-Verhoeff, M.E. (Elize), Mulder, R.H. (Rosa), Saletin, J.M. (Jared M.), Reiss, I.K.M. (Irwin), Horst, G.T.J. (Gijsbertus) van der, Felix, J.F. (Janine), Carskadon, M.A. (Mary A.), Tiemeier, H.W. (Henning), Cecil, C.A.M. (Charlotte), Koopman-Verhoeff, M.E. (Elize), Mulder, R.H. (Rosa), Saletin, J.M. (Jared M.), Reiss, I.K.M. (Irwin), Horst, G.T.J. (Gijsbertus) van der, Felix, J.F. (Janine), Carskadon, M.A. (Mary A.), Tiemeier, H.W. (Henning), and Cecil, C.A.M. (Charlotte)
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Background: DNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population. Methods: This cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis was used to identify highly comethylated DNAm ‘modules’, which were tested for associations with sleep and mental health outcomes. Results: We identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT – a key regulator of Tau proteins in the brain involved in neuronal function – as well as genes previously implicated in sleep duration. Follow-up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood–brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health. Conclusions: We identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep.
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- 2020
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25. Brain Damage and Visuospatial Impairments: Exploring Early Structure-Function Associations in Children Born Very Preterm
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van Gils, M.M. (Maud M.), Dudink, J. (Jeroen), Reiss, I.K.M. (Irwin), Swarte, R.M.C. (Renate), Steen, J. (Hans) van der, Pel, J.J.M. (Johan), Kooiker, M.J.G. (Marlou), van Gils, M.M. (Maud M.), Dudink, J. (Jeroen), Reiss, I.K.M. (Irwin), Swarte, R.M.C. (Renate), Steen, J. (Hans) van der, Pel, J.J.M. (Johan), and Kooiker, M.J.G. (Marlou)
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Background: To provide insight into early neurosensory development in children born very preterm, we assessed the association between early structural brain damage and functional visuospatial attention and motion processing from one to two years corrected age. Methods: In 112 children born at <32 weeks gestational age, we assessed brain damage and growth with a standardized scoring system on magnetic resonance imaging (MRI; 1.5 Tesla) scans performed at 29 to 35 weeks gestational age. Of the children with an MRI scan, 82 participated in an eye tracking-based assessment of visuospatial attention and motion processing (Tobii T60XL) at one year corrected age and 59 at two years corrected age. Results: MRI scoring showed good intra- and inter-rater reproducibility. At one year, 10% children had delayed attentional reaction times and 23% had delayed motion reaction times. Moderate to severe brain damage significantly correlated with sl
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- 2020
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26. Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series
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Poppe, J.A. (Jarinda), Weteringen, W. (Willem) van, Sebek, L.L.G. (Lotte L. G.), Knibbe, C.A.J. (Catherijne), Reiss, I.K.M. (Irwin), Simons, S.H.P. (Sinno), Flint, R.B. (Robert), Poppe, J.A. (Jarinda), Weteringen, W. (Willem) van, Sebek, L.L.G. (Lotte L. G.), Knibbe, C.A.J. (Catherijne), Reiss, I.K.M. (Irwin), Simons, S.H.P. (Sinno), and Flint, R.B. (Robert)
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Introduction: Current drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective pharmacodynamic parameters are generally lacking. By integrating continuous physiological data with model-based drug exposure and data on adverse drug reactions (ADRs), we aimed to show the potential benefit for optimized individual pharmacotherapy. Materials and Methods: Continuous data on oxygen saturation (SpO2), fraction of inspired oxygen (FiO2) and composite parameters, including the SpO2/FiO2 ratio and the cumulative oxygen shortage under the 89% SpO2 limit, served as indicators for doxapram effectiveness. We analyzed these continuous effect data, integrated with doxapram exposure and ADR parameters, obtained in preterm infants around the start of doxapram therapy. The exposures to doxapram and the active metabolite keto-doxapram were simulated using a population pharmacokinetic model. Infants were selected and retrospectively compared on the indication to start doxapram, the first response to doxapram, a potential dose-response relationship, and the administered dosage over time. Recommendations were made for individual improvements of therapy. Results: We provide eight cases of continuous doxapram administration that illustrate a correct and incorrect indication to start doxapram, responders and non-responders to therapy, and unnecessary over-exposure with ADRs. Recommendations for improvement of therapy include: objective evaluation of added effect of doxapram after start, prevention of overdosing by earlier down-titration or termination of therapy, and the prevention of hypoxia and agitation by measuring specific parameters at strategical time-points. Conclusion: Real-time and non-invasive effect monitoring of drug therapy combined with model-based exposure provide
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- 2020
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27. Second and third trimester fetal ultrasound population screening for risks of preterm birth and small-size and large-size for gestational age at birth: a population-based prospective cohort study
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Erkamp, J.S. (Jan), Voerman, E. (Ellis), Steegers, E.A.P. (Eric), Mulders, A.G.M.G.J. (Annemarie), Reiss, I.K.M. (Irwin), Duijts, L. (Liesbeth), Jaddoe, V.W.V. (Vincent), Gaillard, R. (Romy), Erkamp, J.S. (Jan), Voerman, E. (Ellis), Steegers, E.A.P. (Eric), Mulders, A.G.M.G.J. (Annemarie), Reiss, I.K.M. (Irwin), Duijts, L. (Liesbeth), Jaddoe, V.W.V. (Vincent), and Gaillard, R. (Romy)
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BACKGROUND: Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or LGA at birth. We aimed to examine whether single or combined second and third trimest
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- 2020
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28. The influence of Epstein-Barr virus and cytomegalovirus on childhood respiratory health: A population-based prospective cohort study
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Meel, E.R. (Evelien) van, Jaddoe, V.W.V. (Vincent), Reiss, I.K.M. (Irwin), Zelm, M.C. (Menno) van, Jongste, J.C. (Johan) de, Moll, H.A. (Henriëtte), Duijts, L. (Liesbeth), Meel, E.R. (Evelien) van, Jaddoe, V.W.V. (Vincent), Reiss, I.K.M. (Irwin), Zelm, M.C. (Menno) van, Jongste, J.C. (Johan) de, Moll, H.A. (Henriëtte), and Duijts, L. (Liesbeth)
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Background: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection are common in early childhood. CMV infection favours a T-helper-1 and EBV infection a T-helper-2 cell response, possibly leading to disbalanced T-helper cell response, and subsequent risk of asthma or atopy. Objective: To study the associations of EBV and CMV with lung function, asthma and inhalant allergic sensitization at school age. Methods: This study among 3546 children was embedded in a population-based prospective cohort. At age 6 years, serum IgG levels against EBV and CMV were measured by ELISA. At age 10 years, lung function was measured by spirometry, asthma by questionnaire and inhalant allergic sensitization by skin prick test. Results: Unadjusted models showed that seropositivity for EBV was associated with a higher FEV1 and FEF75 (Z-score difference (95% CI): 0.09 (0.02, 0.16) and 0.09 (0.02, 0.15)), while seropositivity for CMV was not. Specific combinations of viruses showed that seropositivity for EBV was only associated with FEV1 and FEF75 in the presence of seropositivity for CMV (0.12 (0.04, 0.20)) and 0.08 (0.01, 0.15)). Seropositivity for CMV in the absence of seropositivity for EBV was associated with an increased risk of inhalant allergic sensitization (OR (95% CI): 1.31 (1.02, 1.68)). All effect estimates attenuated into non-significant mainly after adjustment for child's ethnicity. Seropositivity for EBV or CMV was not associated with asthma. Conclusions and Clinical Relevance: Associations of EBV and CMV infections in early childhood with school-age lung function and inhalant allergic sensitization are explained by ethnicity, or sociodemographic and lifestyle-related factors.
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- 2020
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29. Perinatal stabilisation of infants born with congenital diaphragmatic hernia: A review of current concepts
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Horn-Oudshoorn, E.J.J. (Emily J. J.), Knol, R. (Ronny), Te Pas, A.B. (Arjan B.), Hooper, S.B. (Stuart B.), Cochius-Den Otter, S.C.M. (Suzan), Wijnen, R.M.H. (René), Schaible, T. (Thomas), Reiss, I.K.M. (Irwin), DeKoninck, P.L.J. (Philip L. J.), Horn-Oudshoorn, E.J.J. (Emily J. J.), Knol, R. (Ronny), Te Pas, A.B. (Arjan B.), Hooper, S.B. (Stuart B.), Cochius-Den Otter, S.C.M. (Suzan), Wijnen, R.M.H. (René), Schaible, T. (Thomas), Reiss, I.K.M. (Irwin), and DeKoninck, P.L.J. (Philip L. J.)
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Congenital diaphragmatic hernia (CDH) is associated with high mortality rates and significant pulmonary morbidity, mainly due to disrupted lung development related to herniation of abdominal organs into the chest. Pulmonary hypertension is a major contributor to both mortality and morbidity, however, treatment modalities are limited. Novel prenatal and postnatal interventions, such as fetal surgery and medical treatments, are currently under investigation. Until now, the perinatal stabilisation period immediately after birth has been relatively overlooked, although optimising support in these early stages may be vital in improving outcomes. Moreover, physiological parameters obtained from the perinatal stabilisation period could serve as early predictors of adverse outcomes, thereby facilitating both prevention and early treatment of these conditions. In this review, we focus on the perinatal stabilisation period by discussing the current delivery room guidelines in infants born with CDH, the
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- 2020
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30. Early intervention for children at risk of visual processing dysfunctions from 1 year of age: a randomized controlled trial protocol
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Kooiker, M.J.G. (Marlou), van der Linden, Y. (Yoni), van Dijk, J. (Jenneke), Zee, Y.J. (Ymie) van der, Swarte, R.M.C. (Renate), Smit, L.S. (Liesbeth S.), Van Der Steen-Kant, S.P., Loudon, S.E. (Sjoukje), Reiss, I.K.M. (Irwin), Kuyper, K. (Kees), Pel, J.J.M. (Johan), van der Steen, J. (Johannes), Kooiker, M.J.G. (Marlou), van der Linden, Y. (Yoni), van Dijk, J. (Jenneke), Zee, Y.J. (Ymie) van der, Swarte, R.M.C. (Renate), Smit, L.S. (Liesbeth S.), Van Der Steen-Kant, S.P., Loudon, S.E. (Sjoukje), Reiss, I.K.M. (Irwin), Kuyper, K. (Kees), Pel, J.J.M. (Johan), and van der Steen, J. (Johannes)
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BACKGROUND: An increasing number of children are suffering from brain damage-related visual processing dysfunctions (VPD). There is currently a lack of evidence-based intervention methods that can be used early in development. We developed a visual intervention protocol suitable from 1 year of age. The protocol is structured, comprehensive and individually adaptive, and is paired with quantitative outcome assessments. Our aim is to investigate the effectiveness of this first visual intervention program for young children with (a risk of) VPD. METHODS: This is a single-blind, placebo-controlled trial that is embedded within standard clinical care. The study population consists of 100 children born very or extremely preterm (< 30 weeks) at 1 year of corrected age (CA), of whom 50% are expected to have VPD. First, children undergo a visual screening at 1 year CA. If they are classified as being at risk of VPD, they are referred to standard care, which involves an ophthalmic and visual function assessment and a (newly developed) visual intervention program. This program consists of a general protocol (standardized and similar for all children) and a supplement protocol (adapted to the specific needs of the child). Children are randomly allocated to an intervention group (starting upon inclusion at 1 year CA) or a control group (postponed: starting at 2 years CA). The control group will receive a placebo treatment. The effectiveness of early visual intervention will be examined with follow-up visual and neurocognitive assessments after 1 year (upon completion of the direct intervention) and after 2 years (upon completion of the postponed intervention). DISCUSSION: Through this randomized controlled trial we will establish the effectiveness of a new and early
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- 2020
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31. Does a narrative retelling task improve the assessment of language proficiency in school-aged children born very preterm?
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Stipdonk, L.W. (Lottie W.), Dudink, J. (Jeroen), Reiss, I.K.M. (Irwin), Franken, M.-C. (Marie-Christine), Stipdonk, L.W. (Lottie W.), Dudink, J. (Jeroen), Reiss, I.K.M. (Irwin), and Franken, M.-C. (Marie-Christine)
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Almost half of the children born very preterm (VP) experience language difficulties at school-age, specifically with more complex language tasks. Narrative retelling is such a task. Therefore, we explored the value of narrative retelling assessment in school-aged children born VP, compared to item-based language assessment. In 63 children born VP and 30 age-matched full-term (FT) controls Renfrew’s Bus Story Test and Clinical Evaluation of Language Fundamentals were assessed. The retelling of the Bus Story was transcribed and language complexity and content measures were analyzed with Computerised Language Analysis software. Narrative outcomes of the VP group were worse than that of the FT group. Group differences were significant for the language complexity measures, but not for the language content measures. However, the mean narrative composite score of the VP group was significantly better than their mean item-based language score, while in the FT group the narrative score was worse than the item-based score. Significant positive correlations between narrative and item-based language scores were found only in the VP group. In conclusion, in VP children narrative retelling appears to be less sensitive to detecting academic language problems than item-based language assessment. This might be related to the mediating role of attention in item-based tasks, that appears not to affect more spontaneous language tasks such as retelling. Therefore, in school-aged children born VP we recommend using narrative assessment, in addition to item-based assessments, because it is more related to spontaneous language and less sensitive to attention problems.
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- 2020
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32. Larger First-Trimester Placental Volumetric Parameters Are Associated With Lower Pressure and More Flow-Mediated Vasodilation of the Fetoplacental Vasculature After Delivery
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Hitzerd, E. (Emilie), Reijnders, I.F. (Ignatia), Mulders, A.G.M.G.J. (Annemarie), Koning, A.H.J. (Anton), Reiss, I.K.M. (Irwin), Danser, A.H.J. (A. H. Jan), Steegers-Theunissen, R.P.M. (Régine P. M.), Simons, S.H.P. (Sinno), Koster, M.P.H. (Maria), Hitzerd, E. (Emilie), Reijnders, I.F. (Ignatia), Mulders, A.G.M.G.J. (Annemarie), Koning, A.H.J. (Anton), Reiss, I.K.M. (Irwin), Danser, A.H.J. (A. H. Jan), Steegers-Theunissen, R.P.M. (Régine P. M.), Simons, S.H.P. (Sinno), and Koster, M.P.H. (Maria)
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Objective: To explore the correlation between in vivo placental volumetric parameters in the first trimester of pregnancy and ex vivo parameters of fetoplacental vascular function after delivery. Methods: In ten singleton physiological pregnancies, placental volume (PV) and uteroplacental vascular volume (uPVV) were measured offline in three-dimensional ultrasound volumes at 7, 9, and 11 weeks gestational age (GA) using Virtual Organ Analysis and Virtual Reality. Directly postpartum, term placentas were ex vivo dually perfused and pressure in the fetoplacental vasculature was measured to calculate baseline pressure (pressure after a washout period), pressure increase (pressure after a stepwise fetal flow rate increase of 1 mL/min up to 6 mL/min) and flow-mediated vasodilation (FMVD; reduction in inflow hydrostatic pressure on the fetal side at 6 mL/min flow rate). Correlations between in vivo and ex vivo parameters were assessed by Spearman’s correlation coefficients (R). Results: Throug
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- 2020
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33. Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia
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Slingerland, B.C.G.C. (Bibi), Vos, M.C. (Margreet C.), Bras, W. (Willeke), Kornelisse, R.F. (René), De Coninck, D. (Dieter), Belkum, A.F. (Alex) van, Reiss, I.K.M. (Irwin), Goessens, W.H.F. (Wil H F), Klaassen, C.H.W. (Corné H W), Verkaik, N.J. (Nelianne), Slingerland, B.C.G.C. (Bibi), Vos, M.C. (Margreet C.), Bras, W. (Willeke), Kornelisse, R.F. (René), De Coninck, D. (Dieter), Belkum, A.F. (Alex) van, Reiss, I.K.M. (Irwin), Goessens, W.H.F. (Wil H F), Klaassen, C.H.W. (Corné H W), and Verkaik, N.J. (Nelianne)
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BACKGROUND: Neonatal Staphylococcus aureus (S. aureus) bacteremia is an important cause of morbidity and mortality. In this study, we examined whether methicillin-susceptible S. aureus (MSSA) transmission and genetic makeup contribute to the occurrence of neonatal S. aureus bacteremia. METHODS: A retrospective, single-centre study was performed. All patients were included who suffered from S. aureus bacteremia in the neonatal intensive care unit (NICU), Erasmus MC-Sophia, Rotterdam, the Netherlands, between January 2011 and November 2017. Whole-genome sequencing (WGS) was used to characterize the S. aureus isolates, as was also done in comparison to reference genomes. Transmission was considered likely in case of genetically indistinguishable S. aureus isolates. RESULTS: Excluding coagulase-negative staphylococci (CoNS), S. aureus was the most common cause of neonatal bacteremia. Twelve percent (n = 112) of all 926 positive blood cultures from neonates grew S. aureus. Based on core genome multilocus sequence typing (cgMLST), 12 clusters of genetically indistinguishable MSSA isolates were found, containing 33 isolates in total (2-4 isolates per cluster). In seven of these clusters, at least two of the identified MSSA isolates were collected within a time period of one month. Six virulence genes were present in 98-100% of all MSSA isolates. In comparison to S. aureus reference genomes, toxin genes encoding staphylococcal enterotoxin A (sea) and toxic shock syndrome toxin 1 (tsst-1) were present more often in the genomes of bacteremia isolates. CONCLUSION: Transmission of MSSA is a contributing factor to the occurrence of S. aureus bacteremia in neonates. Sea and tsst-1 might play a role in neonatal S. aureus bacteremia.
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- 2020
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34. Quality of probiotic products for preterm infants: Contamination and missing strains
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Vermeulen, M.J. (Marijn), Luijendijk, A. (Ad), Toledo, L. (Letty) van, Kaam, A.H. (Anton) van, Reiss, I.K.M. (Irwin), Vermeulen, M.J. (Marijn), Luijendijk, A. (Ad), Toledo, L. (Letty) van, Kaam, A.H. (Anton) van, and Reiss, I.K.M. (Irwin)
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Probiotics are effective in reducing necrotising enterocolitis in preterm infants, but routine use is not generally adopted. We describe a safety issue concerning contamination by pathogenic bacteria and missing of labelled strains in a probiotic product widely used in neonatal care. We recommend all centres using probiotics in the care of vulnerable patients to consider product safety checks in addition to the quality reports of manufacturers. Meanwhile, clinicians and manufacturers should collaborate to define quality standards for probiotic products in clinical settings as long as specific international regulations are lacking.
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- 2019
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35. Acute Pain Assessment in Prematurely Born Infants Below 29 Weeks A Long Way to Go
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Meesters, N.J., Simons, S.H.P. (Sinno), Rosmalen, J.M. (Joost) van, Holsti, L. (Liisa), Reiss, I.K.M. (Irwin), Dijk, M. (Monique) van, Meesters, N.J., Simons, S.H.P. (Sinno), Rosmalen, J.M. (Joost) van, Holsti, L. (Liisa), Reiss, I.K.M. (Irwin), and Dijk, M. (Monique) van
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Objectives: Neonates born extremely prematurely are at high risk of acute and prolonged pain. Effective treatment requires reliable pain assessment, which is currently missing. Our study explored whether existing pain assessment tools and physiological indicators measure pain and comfort accurately in this population. Materials and Methods: We prospectively collected data in 16 neonates born at less than 29 weeks’ gestational age during 3 conditions: skin-to-skin care, rest, and heelstick procedure for capillary blood sampling in the incubator. The neonates were video recorded in these situations, and recordings were coded using 5 observational pain assessment tools and numeric rating scales for pain and distress. We simultaneously collected heart rate, respiratory rate, arterial oxygen saturation, regional cerebral oxygenation, and the number of skin conductance peaks. All measures across the 3 conditions were compared using general linear modeling. Results: The median gestational age was 27.1 weeks (range: 24.1 to 28.7). Forty measurement periods across the 3 conditions were analyzed. Heart rate was significantly higher during heelstick procedures compared with during rest, with a mean difference of 10.7 beats/min (95% confidence interval [CI]: 2.7-18.6). Oxygen saturation was significantly higher during skin-to-skin care compared with during heelstick procedures with a mean difference of 5.5% (95% CI: 0.2-10.8). The Premature Infant Pain Profile-revised (PIPP-R) score was significantly higher during heelstick procedures compared with skin-to-skin care with a mean difference of 3.2 points (95% CI: 1.6-5.0). Discussion: Pain measurement in clinical practice in prematurely born infants below 29 weeks remains challenging. The included behavioral and physiological indicators did not adequately distinguish between a painful situation, rest, and skin-to-skin care in premature neonates.
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- 2019
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36. Ibuprofen treatment after the first days of life in preterm neonates with patent ductus arteriosus
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de Klerk, J.C.A. (Johan C. A.), van Paassen, N. (Nanda), Beynum, I.M. (Ingrid) van, Flint, R.B. (Robert), Reiss, I.K.M. (Irwin), Simons, S.H.P. (Sinno), de Klerk, J.C.A. (Johan C. A.), van Paassen, N. (Nanda), Beynum, I.M. (Ingrid) van, Flint, R.B. (Robert), Reiss, I.K.M. (Irwin), and Simons, S.H.P. (Sinno)
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Aim: Patent ductus arteriosus (PDA) is treated with ibuprofen and it is known that the clearance of ibuprofen increases with postnatal age. We aimed to study whether postnatal age-adjusted ibuprofen dosages improve the effectiveness of treatment compared to standard ibuprofen dosages after the first days of life. Methods: A historical cohort of 207 preterm neonates treated with standard ibuprofen dosages (Group A; 2011–2015) was compared to a prospective cohort of 66 preterm neonates treated with postnatal age-adjusted ibuprofen dosages (Group B; 2015–2016). Results: Both groups had comparable background characteristics. Treatment was started after median 6 (25–75th percentile: 4–11) and 5 (25–75th percentile: 4–11) days and effectiveness was 33.2 and 44.7% (p =.17) in groups A and B, respectively. No hemodynamically significant PDA was found in 23/49 (46.9%) of the patients born before 28 weeks after adjusted ibuprofen dosages compared to 48/162 (29.6%) after standard ibuprofen dosages (p =.04). There were significantly more reversible side effects with the postnatal age-adjusted ibuprofen dosages (p =.04). Conclusions: There seems to be a trend to higher effectiveness with the adjusted ibuprofen dosages in preterm neonates before 28 weeks, but it is associated with more reversible side effects.
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- 2019
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37. Investigating the effect of England's smoke-free private vehicle regulation on changes in tobacco smoke exposure and respiratory disease in children: a quasi-experimental study
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Faber, T. (Timor), Mizani, M.A. (Mehrdad A.), Sheikh, A. (Aziz), Mackenbach, J.P. (Johan), Reiss, I.K.M. (Irwin), Been, J.V. (Jasper V.), Faber, T. (Timor), Mizani, M.A. (Mehrdad A.), Sheikh, A. (Aziz), Mackenbach, J.P. (Johan), Reiss, I.K.M. (Irwin), and Been, J.V. (Jasper V.)
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BACKGROUND: Comprehensive tobacco control policies can help to protect children from tobacco smoke exposure and associated adverse respiratory health consequences. We investigated the impact of England's 2015 regulation that prohibits smoking in a private vehicle with children present on changes in environmental tobacco smoke exposure and respiratory health in children. METHODS: In this quasi-experimental study, we used repeated cross-sectional, nationally representative data from the Health Survey for England from Jan 1, 2008, to Dec 31, 2017, of children aged up to 15 years. We did interrupted time series logistic or ordinal regression analyses to assess changes in prevalence of self-reported respiratory conditions, prevalence of self-reported childhood tobacco smoke exposure (children aged 8-15 years only), and salivary cotinine levels (children aged 2 years or older) before and after implementation of the smoke-free private vehicle regulation on Oct 1, 2015. Children who were considered active smokers were excluded from the analyses of salivary cotinine levels. Our primary outcome of interest was self-reported current wheezing or asthma, defined as having medicines prescribed for these conditions. Analyses were adjusted for underlying time trends, quarter of year, sex, age, Index of Multiple Deprivation quintile, and urbanisation level. FINDINGS: 21 096 children aged 0-15 years were included in our dataset. Implementation of the smoke-free private vehicle regulation was not associated with a demonstrable change in self-reported current wheezing or asthma (adjusted odds ratio 0·81, 95% CI 0·62-1·05; p=0·108; assessed in 13 369 children), respiratory conditions (1·02, 0·80-1·29; p=0·892; assessed in 17 006 children), or respiratory conditions probably affecting stamina, breathing, or fatigue (0·75, 0·47-1·19; p=0·220; assessed in 12 386 children). Self-reported tobacco smoke exposure and salivary cotinine levels generally decreased over the study period. There was
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- 2019
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38. Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis
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Duin, R.W.B. (Richard) van, Stam, K., Uitterdijk, D.B. (André), Bartelds, B., Danser, A.H.J. (Jan), Reiss, I.K.M. (Irwin), Duncker, D.J.G.M. (Dirk), Merkus, D. (Daphne), Duin, R.W.B. (Richard) van, Stam, K., Uitterdijk, D.B. (André), Bartelds, B., Danser, A.H.J. (Jan), Reiss, I.K.M. (Irwin), Duncker, D.J.G.M. (Dirk), and Merkus, D. (Daphne)
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Pulmonary hypertension (PH) as a result of pulmonary vein stenosis (PVS) is extremely difficult to treat. The ideal therapy should not target the high-pressure/low-flow (HP/LF) vasculature that drains into stenotic veins, but only the high-pressure/high-flow (HP/HF) vasculature draining into unaffected pulmonary veins, reducing vascular resistance and pressure without risk of pulmonary oedema. We aimed to assess the activity of the nitric oxide (NO) pathway in PVS during the development of PH, and investigate whether interventions in the NO pathway differentially affect vasodilation in the HP/HF vs. HP/LF territories. Swine underwent pulmonary vein banding (PVB; n = 7) or sham surgery
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- 2019
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39. Novel transcutaneous sensor combining optical tcPO2 and electrochemical tcPCO2 monitoring with reflectance pulse oximetry
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Weteringen, W. (Willem) van, Goos, T.G. (Tom), van Essen, T. (Tanja), Ellenberger, C. (Christoph), Hayoz, J. (Josef), Jonge, R.C.J. (Rogier) de, Reiss, I.K.M. (Irwin), Schumacher, P.M. (Peter M.), Weteringen, W. (Willem) van, Goos, T.G. (Tom), van Essen, T. (Tanja), Ellenberger, C. (Christoph), Hayoz, J. (Josef), Jonge, R.C.J. (Rogier) de, Reiss, I.K.M. (Irwin), and Schumacher, P.M. (Peter M.)
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This study investigated the accuracy, drift, and clinical usefulness of a new optical transcutaneous oxygen tension (tcPO2) measuring technique, combined with a conventional electrochemical transcutaneous carbon dioxide (tcPCO2) measurement and reflectance pulse oximetry in the novel transcutaneous OxiVenT™ Sensor. In vitro gas studies were performed to measure accuracy and drift of tcPO2 and tcPCO2. Clinical usefulness for tcPO2 and tcPCO2 monitoring was assessed in neonates. In healthy adult volunteers, measured oxygen saturation values (SpO2) were compared with arterially sampled oxygen saturation values (SaO2) during controlled hypoxemia. In vitro correlation and agreement with gas mixtures of tcPO2 (r = 0.999, bias 3.0 mm Hg, limits of agreement − 6.6 to 4.9 mm Hg) and tcPCO2 (r = 0.999, bias 0.8 mm Hg, limits of agreement − 0.7 to 2.2 mm Hg) were excellent. In vitro drift was negligible for tcPO2 (0.30 (0.63 SD) mm Hg/24 h) and highly acceptable for tcPCO2 (− 2.53 (1.04 SD) mm Hg/12 h). Clinical use in neonates showed good usability and feasibility. SpO2-SaO2 correlation (r = 0.979) and agreement (bias 0.13%, limits of agreement − 3.95 to 4.21%) in healthy adult volunteers were excellent. The investigated combined tcPO2, tcPCO2, and SpO2 sensor with a new oxygen fluorescence quenching technique is clinically usable and provides good overall accuracy and negligible tcPO2 drift. Accurate and low-drift tcPO2 monitoring offers improved measurement validity for long-term monitoring of blood and tissue oxygenation. [Figure not available: see fulltext.].
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- 2019
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40. Customized versus population birth weight charts for identification of newborns at risk of long-term adverse cardio-metabolic and respiratory outcomes: A population-based prospective cohort study
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Erkamp, J.S. (Jan), Jaddoe, V.W.V. (Vincent), Mulders, A.G.M.G.J. (Annemarie), Steegers, E.A.P. (Eric), Reiss, I.K.M. (Irwin), Duijts, L. (Liesbeth), Gaillard, R. (Romy), Erkamp, J.S. (Jan), Jaddoe, V.W.V. (Vincent), Mulders, A.G.M.G.J. (Annemarie), Steegers, E.A.P. (Eric), Reiss, I.K.M. (Irwin), Duijts, L. (Liesbeth), and Gaillard, R. (Romy)
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Background: Customized birth weight charts take into account physiological maternal characteristics that are known to influence fetal growth to differentiate between physiological and pathological abnormal size at birth. It is unknown whether customized birth weight charts better identify newborns at risk of long-term adverse outcomes than population birth weight charts. We aimed to examine whether birth weight classification according to customized charts is superior to population charts at identification of newborns at risk of adverse cardio-metabolic and respiratory health outcomes. Methods: In a population-based prospective cohort study among 6052 pregnant women and their children, we measured infant catch-up growth, overweight, high blood pressure, hyperlipidemia, liver steatosis, clustering of cardio-metabolic risk factors, and asthma at age 10. Small size and large size for gestational age at birth was defined as birth weight in the lowest or highest decile, respectively, of population or customized charts. Association with birth weight classification was assessed using logistic regression models. Results: Of the total of 605 newborns classified as small size for gestational age by population charts, 150 (24.8%) were reclassified as appropriate size for gestational age by customized charts, whereas of the total of 605 newborns classified as large size for gestational age by population charts, 129 (21.3%) cases were reclassified as appropriate size for gestational age by customized charts. Compared to newborns born appropriate size for gestational age, newborns born small size for gestational age according to customized charts had increased risks of infant catch-up growth (odds ratio (OR) 5.15 (95% confidence interval (CI) 4.22 to 6.29)), high blood pressure (OR 2.05 (95% CI 1.55 to 2.72)), and clustering of cardio-metabolic risk factors at 10 years (OR 1.66 (95% CI 1.18 to 2.34)). No associations were observed for overweight, hyperlipidemia, liver steatosis
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- 2019
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41. Gestational age at birth and sleep duration in early childhood in three population-based cohorts
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Luijk, P.C.M. (Maartje), Kocevska, D. (Desana), Tham, E.K.H. (Elaine K.H.), Gaudreau, H. (Hélène), Reiss, I.K.M. (Irwin), Duijts, L. (Liesbeth), Cai, S. (Shirong), Hillegers, M.H.J. (Manon), Jaddoe, V.W.V. (Vincent), Tiemeier, H.W. (Henning), Broekman, B.F.P. (Birit F.P.), El Marroun, H. (Hanan), Luijk, P.C.M. (Maartje), Kocevska, D. (Desana), Tham, E.K.H. (Elaine K.H.), Gaudreau, H. (Hélène), Reiss, I.K.M. (Irwin), Duijts, L. (Liesbeth), Cai, S. (Shirong), Hillegers, M.H.J. (Manon), Jaddoe, V.W.V. (Vincent), Tiemeier, H.W. (Henning), Broekman, B.F.P. (Birit F.P.), and El Marroun, H. (Hanan)
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Background: Both preterm and post-term births have been associated with neonatal morbidity and mortality, including adverse impact on neurodevelopment. Important neural maturational processes take place during sleep in newborns, but findings on gestational duration and sleep in early childhood are contradictory and often derive from small clinical samples. We studied the association of gestational age at birth with sleep duration in early childhood in three population-based cohorts. Methods: Gestational age at birth and sleep duration were assessed in three population-based cohort studies in The Netherlands (n = 6471), Singapore (n = 862), and Canada (n = 583). Gestational age at birth was assessed using ultrasound in pregnancy in combination with date of birth, and caregivers repeatedly reported on child sleep duration at three, six, 24, and 36 months of age. Generalized estimating equations were used, which were adjusted for confounders, and findings were pooled in a meta-analysis. Results: Children born preterm (<37 weeks of gestation) showed longer sleep duration than children born at term; and children born post-term (≥42 weeks of gestation) showed shorter sleep duration. The meta-analysis indicated a small negative effect of gestational age on child sleep duration (effect size −0.11), when assessed in children born at term only. Conclusion: In early childhood, children with a lower gestational age have a longer sleep duration, even when they are born at term (37–42 weeks of gestation). These subtle yet consistent findings point to the importance of maturational processes during sleep, not only in premature children but also in children born at term after shorter gestational duration.
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- 2019
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42. Preschool family irregularity and the development of sleep problems in childhood
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Koopman-Verhoeff, M.E. (Elize), Serdarevic, F. (Fadila), Kocevska, D. (Desana), Bodrij, F.F. (Fene), Mileva-Seitz, V. (Viara), Reiss, I.K.M. (Irwin), Hillegers, M.H.J. (Manon), Tiemeier, H.W. (Henning), Cecil, C.A.M. (Charlotte), Verhulst, F.C. (Frank), Luijk, M, Koopman-Verhoeff, M.E. (Elize), Serdarevic, F. (Fadila), Kocevska, D. (Desana), Bodrij, F.F. (Fene), Mileva-Seitz, V. (Viara), Reiss, I.K.M. (Irwin), Hillegers, M.H.J. (Manon), Tiemeier, H.W. (Henning), Cecil, C.A.M. (Charlotte), Verhulst, F.C. (Frank), and Luijk, M
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Background: Previous studies have shown that poor family environments are related to more sleep problems; however, little is known about how family irregularity in early life affects the development of sleep problems over
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- 2019
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43. Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function, asthma and allergy. The Generation R Study
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Mensink-Bout, S.M., Meel, E.R. (Evelien) van, Jongste, J.C. (Johan) de, Voortman, R.G. (Trudy), Reiss, I.K.M. (Irwin), Jong, N.W. (Nicolette) de, Jaddoe, V.W.V. (Vincent), Duijts, L. (Liesbeth), Mensink-Bout, S.M., Meel, E.R. (Evelien) van, Jongste, J.C. (Johan) de, Voortman, R.G. (Trudy), Reiss, I.K.M. (Irwin), Jong, N.W. (Nicolette) de, Jaddoe, V.W.V. (Vincent), and Duijts, L. (Liesbeth)
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Background: Vitamin D deficiency in early life might affect the developing lung and immune system, and subsequently influence the risk of asthma and allergy in later life. Objective: We examined the associations of 25‐hydroxyvitamin D concentrations in mid‐gestation and at birth with lung function, asthma, inhalant allergic sensitization and inhalant allergy at school‐age. Methods: This study among 4951 children and their mothers was embedded in a population‐based prospective cohort in Rotterdam, the Netherlands. Maternal ve‐ nous blood samples in mid‐gestation and umbilical cord blood samples at birth were used to determine 25‐hydroxyvitamin D concentrations. At age 10 years, lung func‐ tion was measured by spirometry, current asthma and physician‐diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. We used multivariable regression models to examine associations. Results: Higher 25‐hydroxyvitamin D concentrations in mid‐gestation were associ‐ ated with a higher forced vital capacity (FVC), but a lower forced expiratory volume in 1 second/FVC (FEV1/FVC) and a lower forced expiratory flow after exhaling 75% of FVC (FEF75) (Z‐score differences [95% CI] 0.02 [0.00, 0.03], −0.02 [−0.03, −0.01] and −0.01 [‐0.03, −0.00], respectively, per 10 nmol/L 25‐hydroxyvitamin D), but not with asthma. Furthermore, higher 25‐hydroxyvitamin D concentrations in mid‐gesta‐ tion were associated with an increased risk of inhalant allergy (Odds Ratio [95% CI] 1.07 [1.02, 1.12]), but not with inhalant allergic sensitization. After additional adjust‐ ment for child's 25‐hydroxyvitamin D concentrations at the age of 6 years, only the associations of 25‐hydroxyvitamin D concentrations in mid‐gestation with FEV1
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- 2019
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44. Third Trimester Fetal Cardiac Blood Flow and Cardiac Outcomes in School-Age Children Assessed By Magnetic Resonance Imaging
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Toemen, L. (Liza), Jelic, G. (Gavro), Kooijman, M.N. (Marjolein), Gaillard, R. (Romy), Helbing, W.A. (Willem), Lugt, A. (Aad) van der, Roest, A.A., Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), Jaddoe, V.W.V. (Vincent), Toemen, L. (Liza), Jelic, G. (Gavro), Kooijman, M.N. (Marjolein), Gaillard, R. (Romy), Helbing, W.A. (Willem), Lugt, A. (Aad) van der, Roest, A.A., Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), and Jaddoe, V.W.V. (Vincent)
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Background An adverse fetal environment leads to fetal hemodynamic adaptations with cardiac flow alterations that may subsequently affect cardiac development. We examined the associations of third trimester placental and fetal cardiac hemodynamics with cardiac outcomes in school-age children. Methods and Results We performed a population-based prospective cohort study among 547 mothers and their children. At a gestational age of 30.4 (95% range 28.4-32.7) weeks, we measured umbilical and cerebral artery resistance, cardiac output, and tricuspid and mitral E/A waves with Doppler. At the median age of 10.0 years (95% range 9.4-11.7) we measured cardiac outcomes with cardiac magnetic resonance imaging. Cardiac outcomes included right ventricular end-diastolic volume) and right ventricular ejection fraction, left ventricular end diastolic volume and left ventricular ejection fraction, left ventricular mass, an
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- 2019
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45. Sildenafil for bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis
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van der Graaf, M. (Marisa), Rojer, L.A. (Leonne Arindah), Helbing, W.A. (Willem), Reiss, I.K.M. (Irwin), Etnel, J.R.G. (Jonathan), Bartelds, B. (Beatrijs), van der Graaf, M. (Marisa), Rojer, L.A. (Leonne Arindah), Helbing, W.A. (Willem), Reiss, I.K.M. (Irwin), Etnel, J.R.G. (Jonathan), and Bartelds, B. (Beatrijs)
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Bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants and often complicated by pulmonary hypertension (PH), leading to substantial morbidity and mortality. Sildenafil is often used to treat PH and improve symptoms in this condition, even though evidence of safety and effectiveness is scarce. The aim of this study was to perform a systematic review and meta-analysis about the effectiveness and safety of chronic use of sildenafil in preterm infants with BPD-associated PH. Data sources were PubMed, EMBASE, and Medline. Studies reporting the effectiveness of sildenafil therapy in BPD-associated PH in newborns and infants were included. All-cause mortality, improvement in PH, improvement in respiratory scores, and adverse events were extracted. Five studies were included, yielding a total of 101 patients with 94.2 patient-years of total follow-up. The pooled mortality rate was 29.7%/year (95% confidence interval [CI] = 6.8–52.7). Estimated pulmonary arterial pressure improved > 20% in 69.3% (95% CI = 56.8–81.8) of patients within 1–6 months. Respiratory scores improved in 15.0% (95% CI = 0.0–30.4) of patients within 2–7 days. There were no serious adverse events during sildenafil therapy. This systematic review shows that in the treatment of BPD-associated PH in preterm infants, sildenafil may be associated with improvement in PAP and respiratory scores. However, there is no clear evidence of its effect on mortality rates. Considering BPD as a complex disease with variable expression patterns, these results support the need for a prospective registry and standardized approach.
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- 2019
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46. Fetal umbilical, cerebral and pulmonary blood flow patterns in relation to lung function and asthma in childhood. The Generation R Study
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Kooijman, M.N. (Marjolein), Meel, E.R. (Evelien) van, Steegers, E.A.P. (Eric), Reiss, I.K.M. (Irwin), Jongste, J.C. (Johan) de, Jaddoe, V.W.V. (Vincent), Duijts, L. (Liesbeth), Kooijman, M.N. (Marjolein), Meel, E.R. (Evelien) van, Steegers, E.A.P. (Eric), Reiss, I.K.M. (Irwin), Jongste, J.C. (Johan) de, Jaddoe, V.W.V. (Vincent), and Duijts, L. (Liesbeth)
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Background: Fetal growth restriction is associated with higher risks of childhood respiratory morbidity. Fetal blood flow adaptations might contribute to these associations. We examined the associations of fetal umbilical, cerebral, and pulmonary blood flow with wheezing patterns, lung function, and asthma in childhood. Methods: In a population-based prospective cohort study among 903 children, we measured fetal umbilical, cerebral, and pulmonary blood flow by pulsed-wave Doppler at a median gestational age of 30.3 (95% range 28.8-32.3) weeks. We obtained information about wheezing patterns until the age of 6 years by questionnaires. Lung function was measured by spirometry and information about current asthma was obtained by questionnaire at the age of 10 years. Results: Results showed a non-significant relationship between a higher umbilical artery pulsatility index (PI) and umbilical artery PI/cerebral artery PI ratio, indicating fetal blood flow redistribution at the expense of the trunk, with higher risks of early wheezing (OR [95% CI]: 2.07 (0.70-6.10) and 2.74 (0.60, 12.62) per unit increase, respectively). A higher pulmonary artery time velocity integral, indicating higher pulmonary vascular resistance, was associated with a higher risk of late/persistent wheezing (Z-score 1.14 [1.01-1.29]). A higher middle cerebral artery PI was associated with a higher FEV1/FVC (Z-score [95% CI]: 0.21 [0.01-0.42]). Results did not materially change after additional adjustment for birth and growth characteristics. Conclusion: Third-trimester fetal blood flow patterns might be related to childhood respiratory health. These findings should be considered as hypothesis generating and need further replication.
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- 2019
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47. RAIN study: A protocol for a randomised controlled trial evaluating efficacy, safety and cost-effectiveness of intravenous-to-oral antibiotic switch therapy in neonates with a probable bacterial infection
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Keij, F.M. (Fleur), Kornelisse, R.F. (René), Hartwig, N.G. (Nico), Mauff, K.A.L. (Katya), Poley, M.J. (Marten), Allegaert, K.M. (Karel), Reiss, I.K.M. (Irwin), Tramper-Stranders, G.A. (Gerdien), Keij, F.M. (Fleur), Kornelisse, R.F. (René), Hartwig, N.G. (Nico), Mauff, K.A.L. (Katya), Poley, M.J. (Marten), Allegaert, K.M. (Karel), Reiss, I.K.M. (Irwin), and Tramper-Stranders, G.A. (Gerdien)
- Abstract
__Introduction__ High morbidity and mortality rates of proven bacterial infection are the main reason for substantial use of intravenous antibiotics in neonates during the first week of life. In older children, intravenous-to-oral switch after 48 hours of intravenous therapy has been shown to have many advantages and is nowadays commonly practised. We, therefore, aim to evaluate the effectiveness, safety and cost-effectiveness of an early intravenous-to-oral switch in neonates with a probable bacterial infection. __Methods and analysis__ We present a protocol for a multicentre randomised controlled trial assessing the non-inferiority of an early intravenous-to-oral antibiotic switch compared with a full course of intravenous antibiotics in neonates (0-28 days of age) with a probable bacterial infection. Five hundred and fifty patients will be recruited in 17 hospitals in the Netherlands. After 48 hours of intravenous treatment, they will be assigned to either continue with intravenous therapy for another 5 days (control) or switch to amoxicillin/clavulanic acid suspension (intervention). Both groups will be treated for a total of 7 days. The primary outcome will be bacterial (re)infection within 28 days after treatment completion. Secondary outcomes are the pharmacokinetic profile of oral amoxicillin/clavulanic acid, the impact on quality of life, cost-effectiveness, impact on microbiome development and additional yield of molecular techniques in diagnosis of probable bacterial infection. __Ethics and dissemination__ This study has been approved by the Medical Ethics Committee of the Erasmus Medical Centre. Results will be presented in peer-reviewed journals and at international conferences.
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- 2019
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48. Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol
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van der Geest, B.A.M., de Graaf, J.P., Bertens, L.C.M., Poley, M.J. (Marten), Ista, E. (Erwin), Kornelisse, R.F. (René), Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), Been, J.V. (Jasper), Baartmans, M.G.A. (Martin), Bekhof, J., Buijs, H., Bunt, J.E., Dijk, P.H. (Peter), Huizer, M.C., Hulzebos, C.V. (Christian), Leunissen, R.W.J. (Ralph), Pazur, B., Snoeren, B.P.W., Stam, A.H. (Anine), Wewerinke, L., van der Geest, B.A.M., de Graaf, J.P., Bertens, L.C.M., Poley, M.J. (Marten), Ista, E. (Erwin), Kornelisse, R.F. (René), Reiss, I.K.M. (Irwin), Steegers, E.A.P. (Eric), Been, J.V. (Jasper), Baartmans, M.G.A. (Martin), Bekhof, J., Buijs, H., Bunt, J.E., Dijk, P.H. (Peter), Huizer, M.C., Hulzebos, C.V. (Christian), Leunissen, R.W.J. (Ralph), Pazur, B., Snoeren, B.P.W., Stam, A.H. (Anine), and Wewerinke, L.
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- 2019
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49. Placental effects and transfer of sildenafil in healthy and preeclamptic conditions
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Hitzerd, E. (Emilie), Broekhuizen, M. (Michelle), Mirabito Colafella, K.M. (Katrina M.), Glisic, M. (Marija), Vries, R. (René) de, Koch, B.C.P. (Birgit), de Raaf, M.A. (Michiel A.), Merkus, D. (Daphne), Schoenmakers, S. (Sam), Reiss, I.K.M. (Irwin), Danser, A.H.J. (Jan), Simons, S.H.P. (Sinno), Hitzerd, E. (Emilie), Broekhuizen, M. (Michelle), Mirabito Colafella, K.M. (Katrina M.), Glisic, M. (Marija), Vries, R. (René) de, Koch, B.C.P. (Birgit), de Raaf, M.A. (Michiel A.), Merkus, D. (Daphne), Schoenmakers, S. (Sam), Reiss, I.K.M. (Irwin), Danser, A.H.J. (Jan), and Simons, S.H.P. (Sinno)
- Abstract
Background: The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted due to lack of effect and increased neonatal morbidity. Methods: Ex vivo dual-sided perfusion of an isolated cotyledon and wire-myography on chorionic plate arteries were performed to study the effects of sildenafil and the non-selective PDE inhibitor vinpocetine on the response to the NO donor sodium nitroprusside (SNP) under healthy and PE conditions. Ex vivo perfusion was also used to study placental transfer of sildenafil in 6 healthy and 2 PE placentas. Furthermore, placental mRNA and protein levels of eNOS, iNOS, PDE5 and PDE1 were quantified. Findings: Sildenafil and vinpocetine significantly enhanced SNP responses in chorionic plate arteries of healthy, but not PE placentas. Only sildenafil acutely decreased baseline tension in arteries of both healthy and PE placentas. At steady state, the foetal-to-maternal transfer ratio of sildenafil was 0·37 ± 0·03 in healthy placentas versus 0·66 and 0·47 in the 2 PE placentas. mRNA and protein levels of PDE5, eNOS and iNOS were
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- 2019
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50. Effectiveness of Stabilization of Preterm Infants With Intact Umbilical Cord Using a Purpose-Built Resuscitation Table-Study Protocol for a Randomized Controlled Trial
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Knol, R., Brouwer, E. (Eric), Klumper, F., van den Akker, T., DeKoninck, P, Hutten, G.J., Lopriore, E., van Kaam, AH, Polglase, G.R., Reiss, I.K.M. (Irwin), Hooper, S.B., te Pas, A.B., Knol, R., Brouwer, E. (Eric), Klumper, F., van den Akker, T., DeKoninck, P, Hutten, G.J., Lopriore, E., van Kaam, AH, Polglase, G.R., Reiss, I.K.M. (Irwin), Hooper, S.B., and te Pas, A.B.
- Abstract
Background: Most preterm infants fail to aerate their immature lungs at birth and need respiratory support for cardiopulmonary stabilization. Cord clamping before lung aeration compromises cardiovascular function. Delaying cord clamping until the lung has aerated may be beneficial for preterm infants by optimizing hemodynamic transition and placental transfusion. A new purpose-built resuscitation table (the Concord) has been designed making it possible to keep the cord intact after preterm birth until the lung is aerated and the infant is respiratory stable and breathing [Physiological-Based Cord Clamping (PBCC)]. The aim of this study is to test the hypothesis whether stabilizing preterm infants by PBCC is at least as effective as the standard approach using time-based Delayed Cord Clamping (DCC). Study design: This is a randomized controlled non-inferiority study including 64 preterm infants born at <32 weeks of gestation. Infants will be randomized to either the PBCC approach or standard DCC. In case of PBCC, infants will be stabilized with an intact umbilical cord and the cord will only be clamped when the infant is considered respiratory stable, defined as the establishment of regular spontaneous breathing, a heart rate ≥100 bpm and oxygen saturation above 90% while using inspired fraction of oxygen (FiO2) < 0.40. The Concord will be used, which allows giving respiratory support with an intact umbilical cord. In the DCC group infants are clamped first before they are transferred to the standard resuscitation table for further treatment and stabilization. Cord clamping is time-based and delayed at 30–60 s. The primary outcome will be the time to respiratory stability of the infant, starting from birth. Secondary outcomes will include details of stabilization, important clinical outcomes of prematurity and maternal safety outcomes. Discussion: We expect that PBCC using the Concord may reduce major morbidities and mortality in preterm infants. The current study pr
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- 2019
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