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2. Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment.

Author

Courau, Tristan, Bonnereau, Julie, Chicoteau, Justine, Bottois, Hugo, Remark, Romain, Assante Miranda, Laura, Toubert, Antoine, Blery, Mathieu, Aparicio, Thomas, Allez, Matthieu, and Le Bourhis, Lionel

Subjects
Colorectal cancer, Immunotherapy, MICA/B, NKG2A, Spheroids, Antineoplastic Agents, Immunological, Cell Line, Tumor, Cell Proliferation, Cell Survival, Coculture Techniques, Colorectal Neoplasms, HT29 Cells, Histocompatibility Antigens Class I, Humans, Killer Cells, Natural, Molecular Targeted Therapy, NK Cell Lectin-Like Receptor Subfamily C, Spheroids, Cellular, T-Lymphocytes
Abstract

BACKGROUND: Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant functional assays aimed at studying these failures and the efficacy of cancer immunotherapy in human are scarce. 3D tumor cultures, called tumor organoids or spheroids, represent interesting models to study cancer treatments and could help to challenge these issues. METHODS: We analyzed heterotypic cocultures of human colon tumor-derived spheroids with immune cells to assess the infiltration, activation and function of T and NK cells toward human colorectal tumors in vitro. RESULTS: We showed that allogeneic T and NK cells rapidly infiltrated cell line-derived spheroids, inducing immune-mediated tumor cell apoptosis and spheroid destruction. NKG2D, a key activator of cytotoxic responses, was engaged on infiltrating cells. We thus assessed the therapeutic potential of an antibody targeting the specific ligands of NKG2D, MICA and MICB, in this system. Anti-MICA/B enhanced immune-dependent destruction of tumor spheroid by driving an increased NK cells infiltration and activation. Interestingly, tumor cells reacted to immune infiltration by upregulating HLA-E, ligand of the inhibitory receptor NKG2A expressed by CD8 and NK cells. NKG2A was increased after anti-MICA/B treatment and, accordingly, combination of anti-MICA/B and anti-NKG2A was synergistic. These observations were ultimately confirmed in a clinical relevant model of coculture between CRC patients-derived spheroids and autologous tumor-infiltrating lymphocytes. CONCLUSIONS: Altogether, we show that tumor spheroids represent a relevant tool to study tumor-lymphocyte interactions on human tissues and revealed the antitumor potential of immunomodulatory antibodies targeting MICA/B and NKG2A.

Published
2019

3. Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease

Author

Mortha, Arthur, Remark, Romain, Del Valle, Diane Marie, Chuang, Ling-Shiang, Chai, Zhi, Alves, Inês, Azevedo, Catarina, Gaifem, Joana, Martin, Jerome, Petralia, Francesca, Tuballes, Kevin, Barcessat, Vanessa, Tai, Siu Ling, Huang, Hsin-Hui, Laface, Ilaria, Jerez, Yeray Arteaga, Boschetti, Gilles, Villaverde, Nicole, Wang, Mona D., Korie, Ujunwa M., Murray, Joseph, Choung, Rok-Seon, Sato, Takahiro, Laird, Renee M., Plevy, Scott, Rahman, Adeeb, Torres, Joana, Porter, Chad, Riddle, Mark S., Kenigsberg, Ephraim, Pinho, Salomé S., Cho, Judy H., Merad, Miriam, Colombel, Jean-Frederic, and Gnjatic, Sacha

Published
2022
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4. A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma.

Author

Demaria, Olivier, Habif, Guillaume, Vetizou, Marie, Gauthier, Laurent, Remark, Romain, Chiossone, Laura, Vagne, Constance, Rebuffet, Lucas, Courtois, Rachel, Denis, Caroline, Le Floch, François, Muller, Marianna, Girard-Madoux, Mathilde, Augier, Séverine, Lopez, Julie, Carrette, Barbara, Maguer, Aurélie, Vallier, Jean-Baptiste, Grondin, Gwendoline, and Baron, William

Subjects
KILLER cells, B cell lymphoma, B cells, NON-Hodgkin's lymphoma, T cells
Abstract

NK cells offer a promising alternative to T cell therapies in cancer. We evaluated IPH6501, a clinical-stage, tetraspecific NK cell engager (NKCE) armed with a non-alpha IL-2 variant (IL-2v), which targets CD20 and was developed for treating B cell non-Hodgkin lymphoma (B-NHL). CD20-NKCE-IL2v boosts NK cell proliferation and cytotoxicity, showing activity against a range of B-NHL cell lines, including those with low CD20 density. Whereas it presented reduced toxicities compared with those commonly associated with T cell therapies, CD20-NKCE-IL2v showed greater killing efficacy over a T cell engager targeting CD20 in in vitro preclinical models. CD20-NKCE-IL2v also increased the cell surface expression of NK cell–activating receptors, leading to activity against CD20-negative tumor cells. In vivo studies in nonhuman primates and tumor mouse models further validated its efficacy and revealed that CD20-NKCE-IL2v induces peripheral NK cell homing at the tumor site. CD20-NKCE-IL2v emerges as a potential alternative in the treatment landscape of B-NHL. Editor's summary: Current treatments for B cell–specific non-Hodgkin lymphoma (B-NHL) target CD20+ cancerous B cells but have limited efficacy in relapsed or refractory patients. Demaria et al. developed an antibody-based molecule that targets B-NHL by engaging natural killer (NK) cells with antitumor activity. This tetraspecific NK cell engager (CD20-NKCE-IL2v) is composed of four components, including three components that activate NK cells: an anti-NKp46 antibody fragment, an IgG1 Fc fragment, and a variant of IL-2 that targets the IL-2R without engaging the alpha subunit. An additional anti-CD20 antibody fragment targets B-NHL cells. The authors tested mouse and human versions of CD20-NKCE-IL2v and confirmed specific NK cell activation and antitumor activity at well-tolerated doses in mice and nonhuman primates, thus suggesting investigation of this molecule as a potential B-NHL therapeutic. —Christiana N. Fogg [ABSTRACT FROM AUTHOR]

Published
2024
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5. Preclinical assessment of IPH6501, a first-in-class IL2v-armed tetraspecific NK cell engager directed against CD20 for R/R B-NHL, in comparison with a CD20-targeting T cell engager.

Author

Demaria, Olivier, primary, Vetizou, Marie, additional, Remark, Romain, additional, Chiossone, Laura, additional, Vagne, Constance, additional, Courtois, Rachel, additional, Denis, Caroline, additional, Maguer, Aurélie, additional, Le Floch, François, additional, Represa, Agnès, additional, Blanchard Alvarez, Audrey, additional, Gauthier, Laurent, additional, Quaratino, Sonia, additional, Paturel, Carine, additional, and Vivier, Eric, additional

Published
2024
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6. Combining CD3 density and PD-L1 expression into one prognostic factor identifies patients with an exceptional prognosis

Author

Laban, Simon, additional, Remark, Romain, additional, Idel, Christian, additional, Ribbat-Idel, Julika, additional, Krupar, Rosemarie, additional, Schröck, Andreas, additional, Klümper, Niklas, additional, Döscher, Johannes, additional, Sikora, Andrew G., additional, Abou Kors, Tsima, additional, von Witzleben, Adrian, additional, Vahl, Julius, additional, Grages, Ayla, additional, Sonntag, Michael, additional, Brunner, Cornelia, additional, Hoffmann, Thomas, additional, Perner, Sven, additional, and Gnjatic, Sacha, additional

Published
2024
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7. A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF

Author

Chuang, Ling-Shiang, Villaverde, Nicole, Hui, Ken Y, Mortha, Arthur, Rahman, Adeeb, Levine, Adam P, Haritunians, Talin, Ng, Sok Meng Evelyn, Zhang, Wei, Hsu, Nai-Yun, Facey, Jody-Ann, Luong, Tramy, Fernandez-Hernandez, Heriberto, Li, Dalin, Rivas, Manuel, Schiff, Elena R, Gusev, Alexander, Schumm, L Phillip, Bowen, Beatrice M, Sharma, Yashoda, Ning, Kaida, Remark, Romain, Gnjatic, Sacha, Legnani, Peter, George, James, Sands, Bruce E, Stempak, Joanne M, Datta, Lisa W, Lipka, Seth, Katz, Seymour, Cheifetz, Adam S, Barzilai, Nir, Pontikos, Nikolas, Abraham, Clara, Dubinsky, Marla J, Targan, Stephan, Taylor, Kent, Rotter, Jerome I, Scherl, Ellen J, Desnick, Robert J, Abreu, Maria T, Zhao, Hongyu, Atzmon, Gil, Pe’er, Itsik, Kugathasan, Subra, Hakonarson, Hakon, McCauley, Jacob L, Lencz, Todd, Darvasi, Ariel, Plagnol, Vincent, Silverberg, Mark S, Muise, Aleixo M, Brant, Steven R, Daly, Mark J, Segal, Anthony W, Duerr, Richard H, Merad, Miriam, McGovern, Dermot PB, Peter, Inga, and Cho, Judy H

Subjects
Clinical Research, Genetics, Inflammatory Bowel Disease, Digestive Diseases, Crohn's Disease, 2.1 Biological and endogenous factors, Aetiology, Case-Control Studies, Crohn Disease, Cytokine Receptor Common beta Subunit, Female, Frameshift Mutation, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Intestines, Jews, Male, Monocytes, Risk Factors, Signal Transduction, IBD, Risk Factor, Ethnic Variation, Clinical Sciences, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Abstract

Background & aimsCrohn's disease (CD) has the highest prevalence in Ashkenazi Jewish populations. We sought to identify rare, CD-associated frameshift variants of high functional and statistical effects.MethodsWe performed exome sequencing and array-based genotype analyses of 1477 Ashkenazi Jewish individuals with CD and 2614 Ashkenazi Jewish individuals without CD (controls). To validate our findings, we performed genotype analyses of an additional 1515 CD cases and 7052 controls for frameshift mutations in the colony-stimulating factor 2-receptor β common subunit gene (CSF2RB). Intestinal tissues and blood samples were collected from patients with CD; lamina propria leukocytes were isolated and expression of CSF2RB and granulocyte-macrophage colony-stimulating factor-responsive cells were defined by adenomatous polyposis coli (APC) time-of-flight mass cytometry (CyTOF analysis). Variants of CSF2RB were transfected into HEK293 cells and the expression and functions of gene products were compared.ResultsIn the discovery cohort, we associated CD with a frameshift mutation in CSF2RB (P = 8.52 × 10(-4)); the finding was validated in the replication cohort (combined P = 3.42 × 10(-6)). Incubation of intestinal lamina propria leukocytes with granulocyte-macrophage colony-stimulating factor resulted in high levels of phosphorylation of signal transducer and activator of transcription (STAT5) and lesser increases in phosphorylation of extracellular signal-regulated kinase and AK straining transforming (AKT). Cells co-transfected with full-length and mutant forms of CSF2RB had reduced pSTAT5 after stimulation with granulocyte-macrophage colony-stimulating factor, compared with cells transfected with control CSF2RB, indicating a dominant-negative effect of the mutant gene. Monocytes from patients with CD who were heterozygous for the frameshift mutation (6% of CD cases analyzed) had reduced responses to granulocyte-macrophage colony-stimulating factor and markedly decreased activity of aldehyde dehydrogenase; activity of this enzyme has been associated with immune tolerance.ConclusionsIn a genetic analysis of Ashkenazi Jewish individuals, we associated CD with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with CD.

Published
2016

8. Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Author

Gauthier, Laurent, Morel, Ariane, Anceriz, Nadia, Rossi, Benjamin, Blanchard-Alvarez, Audrey, Grondin, Gwendoline, Trichard, Sylvia, Cesari, Cédric, Sapet, Melody, Bosco, Frédéric, Rispaud-Blanc, Hélène, Guillot, Franceline, Cornen, Stéphanie, Roussel, Alain, Amigues, Béatrice, Habif, Guillaume, Caraguel, Flavien, Arrufat, Sandrine, Remark, Romain, Romagné, François, Morel, Yannis, Narni-Mancinelli, Emilie, and Vivier, Eric

Published
2019
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9. Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

Author

André, Pascale, Denis, Caroline, Soulas, Caroline, Bourbon-Caillet, Clarisse, Lopez, Julie, Arnoux, Thomas, Bléry, Mathieu, Bonnafous, Cécile, Gauthier, Laurent, Morel, Ariane, Rossi, Benjamin, Remark, Romain, Breso, Violette, Bonnet, Elodie, Habif, Guillaume, Guia, Sophie, Lalanne, Ana Ines, Hoffmann, Caroline, Lantz, Olivier, Fayette, Jérôme, Boyer-Chammard, Agnès, Zerbib, Robert, Dodion, Pierre, Ghadially, Hormas, Jure-Kunkel, Maria, Morel, Yannis, Herbst, Ronald, Narni-Mancinelli, Emilie, Cohen, Roger B., and Vivier, Eric

Published
2018
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10. Single-cell immune landscape of human atherosclerotic plaques

Author

Fernandez, Dawn M., Rahman, Adeeb H., Fernandez, Nicolas F., Chudnovskiy, Aleksey, Amir, El-ad David, Amadori, Letizia, Khan, Nayaab S., Wong, Christine K., Shamailova, Roza, Hill, Christopher A., Wang, Zichen, Remark, Romain, Li, Jennifer R., Pina, Christian, Faries, Christopher, Awad, Ahmed J., Moss, Noah, Bjorkegren, Johan L. M., Kim-Schulze, Seunghee, Gnjatic, Sacha, Ma’ayan, Avi, Mocco, J, Faries, Peter, Merad, Miriam, and Giannarelli, Chiara

Published
2019
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12. S258: IPH6501 IS A FIRST-IN-CLASS TETRASPECIFIC ANTIBODY-BASED NATURAL KILLER CELL ENGAGER THERAPEUTIC DEVELOPED FOR THE TREATMENT OF B-CELL NON-HODGKIN’S LYMPHOMAS

Author

Demaria, Olivier, primary, Habif, Guillaume, additional, Le Floch, Francois, additional, Muller, Marianna, additional, Chiossone, Laura, additional, Remark, Romain, additional, Vetizou, Marie, additional, Maurel, Nadia, additional, Morel, Ariane, additional, Gauthier, Laurent, additional, Morel, Yannis, additional, Paturel, Carine, additional, and Vivier, Eric, additional

Published
2023
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13. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Author

Lavin, Yonit, Kobayashi, Soma, Leader, Andrew, Amir, El-ad David, Elefant, Naama, Bigenwald, Camille, Remark, Romain, Sweeney, Robert, Becker, Christian D., Levine, Jacob H., Meinhof, Klaus, Chow, Andrew, Kim-Shulze, Seunghee, Wolf, Andrea, Medaglia, Chiara, Li, Hanjie, Rytlewski, Julie A., Emerson, Ryan O., Solovyov, Alexander, Greenbaum, Benjamin D., Sanders, Catherine, Vignali, Marissa, Beasley, Mary Beth, Flores, Raja, Gnjatic, Sacha, Pe’er, Dana, Rahman, Adeeb, Amit, Ido, and Merad, Miriam

Published
2017
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15. Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

Author

Salmon, Hélène, Idoyaga, Juliana, Rahman, Adeeb, Leboeuf, Marylène, Remark, Romain, Jordan, Stefan, Casanova-Acebes, Maria, Khudoynazarova, Makhzuna, Agudo, Judith, Tung, Navpreet, Chakarov, Svetoslav, Rivera, Christina, Hogstad, Brandon, Bosenberg, Marcus, Hashimoto, Daigo, Gnjatic, Sacha, Bhardwaj, Nina, Palucka, Anna Karolina, Brown, Brian D., Brody, Joshua, Ginhoux, Florent, and Merad, Miriam

Published
2016
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16. Supplementary Figure 2 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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17. Supplementary Figure 1 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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18. Supplementary Figure Legend from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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19. Supplementary Table 2 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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20. Supplementary Figure 4 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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21. Supplementary Table 1 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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22. Supplementary Table 3 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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23. Supplementary Figure 3 from Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Author

Remark, Romain, primary, Alifano, Marco, primary, Cremer, Isabelle, primary, Lupo, Audrey, primary, Dieu-Nosjean, Marie-Caroline, primary, Riquet, Marc, primary, Crozet, Lucile, primary, Ouakrim, Hanane, primary, Goc, Jeremy, primary, Cazes, Aurélie, primary, Fléjou, Jean-François, primary, Gibault, Laure, primary, Verkarre, Virginie, primary, Régnard, Jean-François, primary, Pagès, Olivier-Nicolas, primary, Oudard, Stéphane, primary, Mlecnik, Bernhard, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf-Herman, primary, and Damotte, Diane, primary

Published
2023
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24. Supplementary Table 5 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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25. Supplementary Table 7 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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26. Supplementary Figure 5 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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27. Supplementary Figure 8 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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28. Supplementary Figure 7 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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29. Supplementary Table 4 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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30. Supplementary Table 3 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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31. Supplementary Figure Legend from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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32. Supplementary Figure 3 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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33. Supplementary Figure 6 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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34. Supplementary Table 2 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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35. Supplementary Table 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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36. Supplementary Figure 4 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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37. Supplementary Figure 2 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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38. Supplementary Table 6 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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39. Supplementary Figure 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Author

Goc, Jérémy, primary, Germain, Claire, primary, Vo-Bourgais, Thi Kim Duy, primary, Lupo, Audrey, primary, Klein, Christophe, primary, Knockaert, Samantha, primary, de Chaisemartin, Luc, primary, Ouakrim, Hanane, primary, Becht, Etienne, primary, Alifano, Marco, primary, Validire, Pierre, primary, Remark, Romain, primary, Hammond, Scott A., primary, Cremer, Isabelle, primary, Damotte, Diane, primary, Fridman, Wolf-Herman, primary, Sautès-Fridman, Catherine, primary, and Dieu-Nosjean, Marie-Caroline, primary

Published
2023
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40. Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling

Author

Monteiro-Sepulveda, Milena, Touch, Sothea, Mendes-Sá, Carla, André, Sébastien, Poitou, Christine, Allatif, Omran, Cotillard, Aurélie, Fohrer-Ting, Hélène, Hubert, Edwige-Ludiwyne, Remark, Romain, Genser, Laurent, Tordjman, Joan, Garbin, Kevin, Osinski, Céline, Sautès-Fridman, Catherine, Leturque, Armelle, Clément, Karine, and Brot-Laroche, Edith

Published
2015
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41. IPH6501 Is a Novel NKp46-Targeting Tetraspecific Antibody-Based Natural Killer Cell Engager Therapeutic (ANKET) Armed with a Non-Alpha IL-2 Variant and Developed for the Treatment of CD20-Positive Malignancies

Author

Demaria, Olivier, primary, Habif, Guillaume, additional, Le Floch, François, additional, Chiossone, Laura, additional, Remark, Romain, additional, Vetizou, Marie, additional, Maurel, Nadia, additional, Gauthier, Laurent, additional, Morel, Yannis, additional, Paturel, Carine, additional, Vivier, Eric, additional, and Andre, Pascale, additional

Published
2022
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44. Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant

Author

Demaria, Olivier, primary, Gauthier, Laurent, additional, Vetizou, Marie, additional, Blanchard Alvarez, Audrey, additional, Vagne, Constance, additional, Habif, Guillaume, additional, Batista, Luciana, additional, Baron, William, additional, Belaïd, Nourhène, additional, Girard-Madoux, Mathilde, additional, Cesari, Cedric, additional, Caratini, Melody, additional, Bosco, Frédéric, additional, Benac, Olivier, additional, Lopez, Julie, additional, Fenis, Aurore, additional, Galluso, Justine, additional, Trichard, Sylvia, additional, Carrette, Barbara, additional, Carrette, Florent, additional, Maguer, Aurélie, additional, Jaubert, Solène, additional, Sansaloni, Audrey, additional, Letay-Drouet, Robin, additional, Kosthowa, Camille, additional, Lovera, Naouel, additional, Dujardin, Arnaud, additional, Chanuc, Fabien, additional, Le Van, Mélanie, additional, Bokobza, Sivan, additional, Jarmuzynski, Nicolas, additional, Fos, Camille, additional, Gourdin, Nicolas, additional, Remark, Romain, additional, Lechevallier, Eric, additional, Fakhry, Nicolas, additional, Salas, Sébastien, additional, Deville, Jean-Laurent, additional, Le Grand, Roger, additional, Bonnafous, Cécile, additional, Vollmy, Lukas, additional, Represa, Agnès, additional, Carpentier, Sabrina, additional, Rossi, Benjamin, additional, Morel, Ariane, additional, Cornen, Stéphanie, additional, Perrot, Ivan, additional, Morel, Yannis, additional, and Vivier, Eric, additional

Published
2022
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45. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Author

Balachandran, Vinod P., Łuksza, Marta, Zhao, Julia N., Makarov, Vladimir, Moral, John Alec, Remark, Romain, Herbst, Brian, Askan, Gokce, Bhanot, Umesh, Senbabaoglu, Yasin, Wells, Daniel K., Ormsby Cary, Charles Ian, Grbovic-Huezo, Olivera, Attiyeh, Marc, Medina, Benjamin, Zhang, Jennifer, Loo, Jennifer, Saglimbeni, Joseph, Abu-Akeel, Mohsen, Zappasodi, Roberta, Riaz, Nadeem, Smoragiewicz, Martin, Kelley, Larkin Z., Basturk, Olca, Johns, Amber L., Mead, Scott R., Gill, Anthony J., Chang, David K., McKay, Skye H., Chantrill, Lorraine A., Chin, Venessa T., Chou, Angela, Humphris, Jeremy L., Pajic, Marina, Steinmann, Angela, Arshi, Mehreen, Drury, Ali, Froio, Danielle, Morgan, Ashleigh, Timpson, Paul, Hermann, David, Vennin, Claire, Warren, Sean, Pinese, Mark, Wu, Jianmin, Pinho, Andreia V., Tucker, Katherine, Andrews, Lesley, Samra, Jaswinder S., Arena, Jennifer, Pavlakis, Nick, High, Hilda A., Mittal, Anubhav, Biankin, Andrew V., Bailey, Peter, Martin, Sancha, Musgrove, Elizabeth A., Jones, Marc D., Nourse, Craig, Jamieson, Nigel B., Stoita, Alina, Williams, David, Spigelman, Allan, Waddell, Nicola, Pearson, John V., Patch, Ann-Marie, Nones, Katia, Newell, Felicity, Mukhopadhyay, Pamela, Addala, Venkateswar, Kazakoff, Stephen, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Christina, Grimmond, Sean M., Hofmann, Oliver, Wilson, Peter J., Christ, Angelika, Bruxner, Tim, Asghari, Ray, Merrett, Neil D., Pavey, Darren, Das, Amitabha, Goodwin, Annabel, Cosman, Peter H., Ismail, Kasim, O’Connor, Chelsie, Cooper, Caroline L., Grimison, Peter, Kench, James G., Sandroussi, Charbel, Lam, Vincent W., McLeod, Duncan, Nagrial, Adnan M., Kirk, Judy, James, Virginia, Texler, Michael, Forest, Cindy, Epari, Krishna P., Ballal, Mo, Fletcher, David R., Mukhedkar, Sanjay, Zeps, Nikolajs, Beilin, Maria, Feeney, Kynan, Nguyen, Nan Q., Ruszkiewicz, Andrew R., Worthley, Chris, Chen, John, Brooke-Smith, Mark E., Papangelis, Virginia, Clouston, Andrew D., Martin, Patrick, Barbour, Andrew P., O’Rourke, Thomas J., Fawcett, Jonathan W., Slater, Kellee, Hatzifotis, Michael, Hodgkinson, Peter, Nikfarjam, Mehrdad, Eshleman, James R., Hruban, Ralph H., Wolfgang, Christopher L., Hodgin, Mary, Scarpa, Aldo, Lawlor, Rita T., Beghelli, Stefania, Corbo, Vincenzo, Scardoni, Maria, Bassi, Claudio, Gönen, Mithat, Levine, Arnold J., Allen, Peter J., Fearon, Douglas T., Merad, Miriam, Gnjatic, Sacha, Iacobuzio-Donahue, Christine A., Wolchok, Jedd D., DeMatteo, Ronald P., Chan, Timothy A., Greenbaum, Benjamin D., Merghoub, Taha, and Leach, Steven D.

Published
2017
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47. Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition

Author

Bonnereau, Julie, primary, Courau, Tristan, additional, Asesio, Nicolas, additional, Salfati, Delphine, additional, Bouhidel, Fatiha, additional, Corte, Hélène, additional, Hamoudi, Sarah, additional, Hammoudi, Nassim, additional, Lavolé, Julie, additional, Vivier-Chicoteau, Justine, additional, Chardiny, Victor, additional, Maggiori, Leon, additional, Blery, Mathieu, additional, Remark, Romain, additional, Bonnafous, Cécile, additional, Cattan, Pierre, additional, Toubert, Antoine, additional, Bhat, Purnima, additional, Allez, Matthieu, additional, Aparicio, Thomas, additional, and Le Bourhis, Lionel, additional

Published
2022
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48. Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Author

Carvelli, Julien, Demaria, Olivier, Vély, Frédéric, Batista, Luciana, Chouaki Benmansour, Nassima, Fares, Joanna, Carpentier, Sabrina, Thibult, Marie-Laure, Morel, Ariane, Remark, Romain, André, Pascale, Represa, Agnès, Piperoglou, Christelle, Assante Miranda, Laura, Baron, William, Belaid, Nourhène, Caillet, Clarisse, Caraguel, Flavien, Carrette, Barbara, Carrette, Florent, Chanuc, Fabien, Courtois, Rachel, Fenis, Aurore, Giordano, Marilyn, Girard-Madoux, Mathilde, Giraudon-Paoli, Marc, Gourdin, Nicolas, Grondin, Gwendoline, Guillot, Franceline, Habif, Guillaume, Jaubert, Solène, Lopez, Julie, Le Van, Mélanie, Lovera, Naouel, Mansuy, Marine, Bonnet, Elodie, Sansaloni, Audrey, Reboul, Annick, Mitry, Emmanuel, Nekkar-Constant, Camille, Péri, Valentine, Ricaut, Paul, Simon, Léa, Vallier, Jean-Baptiste, Vétizou, Marie, Zerbib, Robert, Ugolini, Sophie, Etiennot, Marion, Galluso, Justine, Lyonnet, Luc, Forel, Jean-Marie, Papazian, Laurent, Velly, Lionel, André, Baptiste, Briantais, Antoine, Faucher, Benoit, Jean, Estelle, Seguier, Julie, Veit, Veronique, Harlé, Jean-Robert, Pastorino, Boris, Delteil, Clémence, Daniel, Laurent, Boudsocq, Jean-Paul, Clerc, Axelle, Delmond, Emmanuel, Vidal, Pierre-Olivier, Savini, Hélène, Coutard, Bruno, Cordier, Pierre Yves, Le Dault, Erwan, Guervilly, Christophe, Simeone, Pierre, Gainnier, Marc, Morel, Yannis, Ebbo, Mikael, Schleinitz, Nicolas, and Vivier, Eric

Subjects
0301 basic medicine, Acute Lung Injury, Complement C5a, Inflammation, Complement factor I, Lung injury, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Myeloid Cells, Lung, Receptor, Anaphylatoxin C5a, Respiratory Distress Syndrome, CD11b Antigen, Multidisciplinary, medicine.diagnostic_test, SARS-CoV-2, business.industry, COVID-19, respiratory system, Pathophysiology, 3. Good health, Complement system, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Female, medicine.symptom, Cytokine Release Syndrome, business, Bronchoalveolar Lavage Fluid
Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory responses by recruiting and activating neutrophils and monocytes1. Here we provide a longitudinal analysis of immune responses, including phenotypic analyses of immune cells and assessments of the soluble factors that are present in the blood and bronchoalveolar lavage fluid of patients at various stages of COVID-19 severity, including those who were paucisymptomatic or had pneumonia or acute respiratory distress syndrome. The levels of soluble C5a were increased in proportion to the severity of COVID-19 and high expression levels of C5aR1 receptors were found in blood and pulmonary myeloid cells, which supports a role for the C5a-C5aR1 axis in the pathophysiology of acute respiratory distress syndrome. Anti-C5aR1 therapeutic monoclonal antibodies prevented the C5a-mediated recruitment and activation of human myeloid cells, and inhibited acute lung injury in human C5aR1 knock-in mice. These results suggest that blockade of the C5a-C5aR1 axis could be used to limit the infiltration of myeloid cells in damaged organs and prevent the excessive lung inflammation and endothelialitis that are associated with acute respiratory distress syndrome in patients with COVID-19.

Published
2020
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49. Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition.

Author

Bonnereau, Julie, Courau, Tristan, Asesio, Nicolas, Salfati, Delphine, Bouhidel, Fatiha, Corte, Hélène, Hamoudi, Sarah, Hammoudi, Nassim, Lavolé, Julie, Vivier-Chicoteau, Justine, Chardiny, Victor, Maggiori, Leon, Blery, Mathieu, Remark, Romain, Bonnafous, Cécile, Cattan, Pierre, Toubert, Antoine, Bhat, Purnima, Allez, Matthieu, and Aparicio, Thomas

Subjects
T cells, GRANZYMES, RECTAL cancer, T cell receptors, COLORECTAL cancer, MONONUCLEAR leukocytes, REGULATORY T cells, CYTOTOXIC T cells
Published
2023
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