11 results on '"Remi André Olsen"'
Search Results
2. Range-wide and temporal genomic analyses reveal the consequences of near-extinction in Swedish moose
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Nicolas Dussex, Sara Kurland, Remi-André Olsen, Göran Spong, Göran Ericsson, Robert Ekblom, Nils Ryman, Love Dalén, and Linda Laikre
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Biology (General) ,QH301-705.5 - Abstract
Abstract Ungulate species have experienced severe declines over the past centuries through overharvesting and habitat loss. Even if many game species have recovered thanks to strict hunting regulation, the genome-wide impacts of overharvesting are still unclear. Here, we examine the temporal and geographical differences in genome-wide diversity in moose (Alces alces) over its whole range in Sweden by sequencing 87 modern and historical genomes. We found limited impact of the 1900s near-extinction event but local variation in inbreeding and load in modern populations, as well as suggestion of a risk of future reduction in genetic diversity and gene flow. Furthermore, we found candidate genes for local adaptation, and rapid temporal allele frequency shifts involving coding genes since the 1980s, possibly due to selective harvesting. Our results highlight that genomic changes potentially impacting fitness can occur over short time scales and underline the need to track both deleterious and selectively advantageous genomic variation.
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- 2023
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3. Balancing selection in Pattern Recognition Receptor signalling pathways is associated with gene function and pleiotropy in a wild rodent
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Remi André Olsen, Max Lundberg, Lars Råberg, Xiuqin Zhong, and Anna Konrad
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0106 biological sciences ,0301 basic medicine ,Population ,Computational biology ,Biology ,Balancing selection ,010603 evolutionary biology ,01 natural sciences ,Evolution, Molecular ,03 medical and health sciences ,Pleiotropy ,Genetics ,Animals ,Selection, Genetic ,Receptor ,education ,Gene ,Ecology, Evolution, Behavior and Systematics ,education.field_of_study ,Innate immune system ,Arvicolinae ,Pattern recognition receptor ,Genetic Pleiotropy ,Immunity, Innate ,030104 developmental biology ,Receptors, Pattern Recognition ,Function (biology) - Abstract
Pathogen-mediated balancing selection is commonly considered to play an important role in the maintenance of genetic diversity, in particular in immune genes. However, the factors that may influence which immune genes are the targets of such selection are largely unknown. To address this, here we focus on Pattern Recognition Receptor (PRR) signalling pathways, which play a key role in innate immunity. We used whole-genome resequencing data from a population of bank voles (Myodes glareolus) to test for associations between balancing selection, pleiotropy and gene function in a set of 123 PRR signalling pathway genes. To investigate the effect of gene function, we compared genes encoding (a) receptors for microbial ligands versus downstream signalling proteins, and (b) receptors recognizing components of microbial cell walls, flagella and capsids versus receptors recognizing features of microbial nucleic acids. Analyses based on the nucleotide diversity of full coding sequences showed that balancing selection primarily targeted receptor genes with a low degree of pleiotropy. Moreover, genes encoding receptors recognizing components of microbial cell walls etc. were more important targets of balancing selection than receptors recognizing nucleic acids. Tests for localized signatures of balancing selection in coding and noncoding sequences showed that such signatures were mostly located in introns, and more evenly distributed among different functional categories of PRR pathway genes. The finding that signatures of balancing selection in full coding sequences primarily occur in receptor genes, in particular those encoding receptors for components of microbial cell walls etc., is consistent with the idea that coevolution between hosts and pathogens is an important cause of balancing selection on immune genes.
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- 2020
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4. Genomic trajectories of a near-extinction event in the Chatham Island black robin
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Johanna von Seth, Tom van der Valk, Edana Lord, Hanna Sigeman, Remi-André Olsen, Michael Knapp, Olga Kardailsky, Fiona Robertson, Marie Hale, Dave Houston, Euan Kennedy, Love Dalén, Karin Norén, Melanie Massaro, Bruce C. Robertson, and Nicolas Dussex
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Genetic Drift ,Near‑extinction ,Genetics ,Humans ,Genetic Variation ,Translocation ,Inbreeding ,Genomics ,Selection, Genetic ,Alleles ,Bottleneck ,Biotechnology ,Mutational load - Abstract
Background Understanding the micro-evolutionary response of populations to demographic declines is a major goal in evolutionary and conservation biology. In small populations, genetic drift can lead to an accumulation of deleterious mutations, which will increase the risk of extinction. However, demographic recovery can still occur after extreme declines, suggesting that natural selection may purge deleterious mutations, even in extremely small populations. The Chatham Island black robin (Petroica traversi) is arguably the most inbred bird species in the world. It avoided imminent extinction in the early 1980s and after a remarkable recovery from a single pair, a second population was established and the two extant populations have evolved in complete isolation since then. Here, we analysed 52 modern and historical genomes to examine the genomic consequences of this extreme bottleneck and the subsequent translocation. Results We found evidence for two-fold decline in heterozygosity and three- to four-fold increase in inbreeding in modern genomes. Moreover, there was partial support for temporal reduction in total load for detrimental variation. In contrast, compared to historical genomes, modern genomes showed a significantly higher realised load, reflecting the temporal increase in inbreeding. Furthermore, the translocation induced only small changes in the frequency of deleterious alleles, with the majority of detrimental variation being shared between the two populations. Conclusion Our results highlight the dynamics of mutational load in a species that recovered from the brink of extinction, and show rather limited temporal changes in mutational load. We hypothesise that ancestral purging may have been facilitated by population fragmentation and isolation on several islands for thousands of generations and may have already reduced much of the highly deleterious load well before human arrival and introduction of pests to the archipelago. The majority of fixed deleterious variation was shared between the modern populations, but translocation of individuals with low mutational load could possibly mitigate further fixation of high-frequency deleterious variation.
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- 2022
5. Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma
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Lucía Peña-Pérez, Nicolai Frengen, Julia Hauenstein, Charlotte Gran, Charlotte Gustafsson, Jesper Eisfeldt, Marcin Kierczak, Fanny Taborsak-Lines, Remi-André Olsen, Ann Wallblom, Aleksandra Krstic, Philip Ewels, Anna Lindstrand, and Robert Månsson
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DNA Copy Number Variations ,Whole Genome Sequencing ,Humans ,Genomics ,Multiple Myeloma ,In Situ Hybridization, Fluorescence ,Translocation, Genetic - Abstract
Multiple myeloma (MM) is an incurable and aggressive plasma cell malignancy characterized by a complex karyotype with multiple structural variants (SVs) and copy number variations (CNVs). Linked-read whole-genome sequencing (lrWGS) allows for refined detection and reconstruction of SVs by providing long-range genetic information from standard short-read sequencing. This makes lrWGS an attractive solution for capturing the full genomic complexity of MM. Here we show that high-quality lrWGS data can be generated from low numbers of FACS sorted cells without DNA purification. Using this protocol, we analyzed FACS sorted MM cells from 37 MM patients with lrWGS. We found high concordance between lrWGS and FISH for the detection of recurrent translocations and CNVs. Outside of the regions investigated by FISH, we identified >150 additional SVs and CNVs across the cohort. Analysis of the lrWGS data allowed for resolving the structure of diverse SVs affecting the MYC and t(11;14) loci causing the duplication of genes and gene regulatory elements. In addition, we identified private SVs causing the dysregulation of genes recurrently involved in translocations with the IGH locus and show that these can alter the molecular classification of the MM. Overall, we conclude that lrWGS allows for the detection of aberrations critical for MM prognostics and provides a feasible route for providing comprehensive genetics. Implementing lrWGS could provide more accurate clinical prognostics, facilitate genomic medicine initiatives, and greatly improve the stratification of patients included in clinical trials.KEY POINTS- Linked-read WGS can be performed without DNA purification and allows for resolving the diverse structural variants found in multiple myeloma.- Linked-read WGS can, as a stand-alone assay, provide comprehensive genetics in myeloma and other diseases with complex genomes.
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- 2021
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6. Population dynamics and demographic history of Eurasian collared lemmings
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Edana Lord, Aurelio Marangoni, Mateusz Baca, Danijela Popović, Anna V. Goropashnaya, John R. Stewart, Monika V. Knul, Pierre Noiret, Mietje Germonpré, Elodie-Laure Jimenez, Natalia I. Abramson, Sergey Vartanyan, Stefan Prost, Nickolay G. Smirnov, Elena A. Kuzmina, Remi-André Olsen, Vadim B. Fedorov, and Love Dalén
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Arvicolinae ,Arctic Regions ,Population Dynamics ,Animals ,General Medicine ,DNA, Ancient ,Ecosystem - Abstract
Background Ancient DNA studies suggest that Late Pleistocene climatic changes had a significant effect on population dynamics in Arctic species. The Eurasian collared lemming (Dicrostonyx torquatus) is a keystone species in the Arctic ecosystem. Earlier studies have indicated that past climatic fluctuations were important drivers of past population dynamics in this species. Results Here, we analysed 59 ancient and 54 modern mitogenomes from across Eurasia, along with one modern nuclear genome. Our results suggest population growth and genetic diversification during the early Late Pleistocene, implying that collared lemmings may have experienced a genetic bottleneck during the warm Eemian interglacial. Furthermore, we find multiple temporally structured mitogenome clades during the Late Pleistocene, consistent with earlier results suggesting a dynamic late glacial population history. Finally, we identify a population in northeastern Siberia that maintained genetic diversity and a constant population size at the end of the Pleistocene, suggesting suitable conditions for collared lemmings in this region during the increasing temperatures associated with the onset of the Holocene. Conclusions This study highlights an influence of past warming, in particular the Eemian interglacial, on the evolutionary history of the collared lemming, along with spatiotemporal population structuring throughout the Late Pleistocene.
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- 2021
7. Ancient and modern genomes unravel the evolutionary history of the rhinoceros family
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David A. Duchêne, Robert R. Dunn, Peter D. Heintzman, Linda G. R. Bruins-van Sonsbeek, Kees Rookmaaker, Love Dalén, Sergey Vartanyan, Pierre-Olivier Antoine, Holly Heiniger, Joshua D. Kapp, Mikkel-Holger S. Sinding, M. Thomas P. Gilbert, Chentao Yang, Johanna von Seth, Shyam Gopalakrishnan, Beth Shapiro, Nicolas Dussex, Shanlin Liu, Tom van der Valk, Irina V. Kirillova, Michael William Bruford, Kieren J. Mitchell, Cynthia C. Steiner, Alan Cooper, Binia De Cahsan, Tomas Marques-Bonet, Fátima Sánchez-Barreiro, Michael V. Westbury, Lei Chen, Guanliang Meng, Adrian M. Lister, Remi André-Olsen, Oliver A. Ryder, Pavel A. Kosintsev, Eline D. Lorenzen, Ashot Margaryan, Guojie Zhang, Chunxue Guo, Yoshan Moodley, Science for Life Laboratory, Garvan Institute of Medical Research, Knut and Alice Wallenberg Foundation, Swedish Research Council, European Research Council, Independent Research Fund Denmark, Australian Research Council, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Howard Hughes Medical Institute, Generalitat de Catalunya, China Agricultural University (CAU), Universität Potsdam, Department of Bioinformatics and Genetics [Stockholm, Sweden], Swedish Museum of Natural History, Stockholm, The Arctic University Museum of Norway, UiT the Arctic University of Norway, 9010 Tromsø, Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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0106 biological sciences ,GENETIC VARIATION ,Time Factors ,GENETIC VARIABILITY ,SPECIES SPECIFICITY ,RHINOCEROS, PERISSODACTYL, CONSERVATION GENOMICS, PHYLOGENOMICS, GENOMIC DIVERSITY ,01 natural sciences ,Evolutionsbiologi ,DEMOGRAPHY ,MARKOV CHAIN ,MUTATION ,Phylogeny ,Independent research ,media_common ,2. Zero hunger ,0303 health sciences ,Genome ,Geography ,ASIA ,TIME FACTORS ,European research ,[SDV.BA]Life Sciences [q-bio]/Animal biology ,Homozygote ,EXTINCT SPECIES ,food and beverages ,Phylogenomics ,MARKOV CHAINS ,SEQUENCE ANALYSIS ,Markov Chains ,HOMOZYGOTE ,GENOME ,VDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoological anatomy: 481 ,[SDE]Environmental Sciences ,Conservation genomics ,Gene Flow ,AFRICA ,Heterozygote ,food.ingredient ,EUROPE ,GENETICS ,PHYLOGENY ,HETEROZYGOSITY ,GEOGRAPHY ,VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Zoologisk anatomi: 481 ,Library science ,HOST SPECIFICITY ,Rhinoceros ,Biology ,SPECIES DIFFERENCE ,HETEROZYGOTE ,010603 evolutionary biology ,General Biochemistry, Genetics and Molecular Biology ,Host Specificity ,EVOLUTION, MOLECULAR ,Evolution, Molecular ,03 medical and health sciences ,food ,Species Specificity ,GENE FLOW ,media_common.cataloged_instance ,Animals ,NONHUMAN ,Early career ,European union ,Genetik ,ARTICLE ,GENETIC ANALYSIS ,Perissodactyla ,030304 developmental biology ,Demography ,Evolutionary Biology ,INBREEDING ,Unicorn ,UNGULATE ,Genomic diversity ,EXTANT SPECIES ,HOST RANGE ,ANIMALS ,Genetic Variation ,ANIMAL ,EVOLUTION ,MOLECULAR EVOLUTION ,PERISSODACTYLA ,Animal ecology ,Research council ,Mutation ,Perissodactyl ,TIME FACTOR ,MIOCENE - Abstract
Only five species of the once-diverse Rhinocerotidae remain, making the reconstruction of their evolutionary history a challenge to biologists since Darwin. We sequenced genomes from five rhinoceros species (three extinct and two living), which we compared to existing data from the remaining three living species and a range of outgroups. We identify an early divergence between extant African and Eurasian lineages, resolving a key debate regarding the phylogeny of extant rhinoceroses. This early Miocene (∼16 million years ago [mya]) split post-dates the land bridge formation between the Afro-Arabian and Eurasian landmasses. Our analyses also show that while rhinoceros genomes in general exhibit low levels of genome-wide diversity, heterozygosity is lowest and inbreeding is highest in the modern species. These results suggest that while low genetic diversity is a long-term feature of the family, it has been particularly exacerbated recently, likely reflecting recent anthropogenic-driven population declines., The authors acknowledge support from the Science for Life Laboratory, the Garvan Institute of Medical Research, the Knut and Alice Wallenberg Foundation, and the National Genomics Infrastructure funded by the Swedish Research Council and Uppsala Multidisciplinary Center for Advanced Computational Science for assistance with massively parallel sequencing and access to the UPPMAX computational infrastructure. We thank the Natural History Museum at the University of Oslo for providing the Javan rhinoceros sample. We thank the Museum of the Institute of Plant and Animal Ecology (UB RAS, Ekaterinburg) for providing the sample of Siberian unicorn. M.T.P.G. was supported by European Research Council (ERC) Consolidator grant 681396 (Extinction Genomics). E.D.L. was supported by Independent Research Fund Denmark grant 8021-00218B. A.C. was supported by an Australian Research Council Laureate Fellowship (FL140100260). T.M.B. is supported by funding from the ERC under the European Union’s Horizon 2020 research and innovation program (grant agreement 864203), grant BFU2017-86471-P (MINECO/FEDER, UE), “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M), Howard Hughes International Early Career, and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880). L.D. was supported by the Swedish Research Council (2017-04647) and Formas (2018-01640)., With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2018-000792-M).
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- 2021
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8. Evolutionary history, genomic adaptation to toxic diet, and extinction of the carolina Parakeet
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M. Thomas P. Gilbert, Aitor Serres, Guolin Shi, Xianqing Chen, George Pacheco, Ashot Margaryan, Hao Fei, Qi Fang, Agostinho Antunes, Carles Lalueza-Fox, Tomas Marques-Bonet, Marc de Manuel, Pere Renom, Love Dalén, Yuan Deng, Manuel Ferrando-Bernal, Shaohong Feng, Santi Mañosa, Marcela Sandoval-Velasco, Bent O. Petersen, Toni de-Dios, Remi André Olsen, Arcadi Navarro, Pere Gelabert, Guojie Zhang, Josefin Stiller, European Research Council, European Commission, Fundación 'la Caixa', Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Howard Hughes Medical Institute, and Fundação para a Ciência e a Tecnologia (Portugal)
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0301 basic medicine ,Demographic history ,Endangered species ,Zoology ,Extinction, Biological ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Neotropical parrot ,0302 clinical medicine ,Parrots ,Ornithology ,0502 economics and business ,Animals ,050207 economics ,Aratinga solstitialis ,Lloros ,Extinció (Biologia) ,2. Zero hunger ,Genètica de poblacions ,Genome ,050208 finance ,Extinction ,biology ,Parakeets ,05 social sciences ,Genomics ,15. Life on land ,biology.organism_classification ,Biological Evolution ,Diet ,Alimentació ,Ancient genomics ,Carolina parakeet ,Genòmica ,030104 developmental biology ,Habitat destruction ,Extintion (Biology) ,Ornitologia ,Toxic diet ,Adaptation ,General Agricultural and Biological Sciences ,Population genomics ,030217 neurology & neurosurgery - Abstract
As the only endemic neotropical parrot to have recently lived in the northern hemisphere, the Carolina parakeet (Conuropsis carolinensis) was an iconic North American bird. The last surviving specimen died in the Cincinnati Zoo in 1918 [1]. The cause of its extinction remains contentious: besides excessive mortality associated to habitat destruction and active hunting, their survival could have been negatively affected by its range having become increasingly patchy [2] or by the exposure to poultry pathogens [3, 4]. In addition, the Carolina parakeet showed a predilection for cockleburs, an herbaceous plant that contains a powerful toxin, carboxyatractyloside, or CAT [5], which did not seem to affect them but made the birds notoriously toxic to most predators [3]. To explore the demographic history of this bird, we generated the complete genomic sequence of a preserved specimen held in a private collection in Espinelves (Girona, Spain), as well as of a close extant relative, Aratinga solstitialis. We identified two non-synonymous genetic changes in two highly conserved proteins known to interact with CAT that could underlie a specific dietary adaptation to this toxin. Our genomic analyses did not reveal evidence of a dramatic past demographic decline in the Carolina parakeet; also, its genome did not exhibit the long runs of homozygosity that are signals of recent inbreeding and are typically found in endangered species. As such, our results suggest its extinction was an abrupt process and thus likely solely attributable to human causes. Gelabert et al. report the whole genome of the extinct Carolina parakeet and provide evidence of its phylogeny, adaptation to a toxic cocklebur diet, and demographic history. The lack of signs of recent inbreeding typically found in endangered species suggests its abrupt extinction was human mediated., This work was supported by ERC Consolidator Grant 681396 “Extinction Genomics” to M.T.P.G. and M.S.-V., Obra Social ‘‘La Caixa’’ and Secretaria d’Universitats i Recerca ( GRC2017-SGR880 ) to T.M.-B. and C.L.-F., BFU2017-86471-P and PGC2018-101927-B-I00 from MINECO/FEDER, UE to T.M.-B, and PGC2018-095931-B-100 from MINECO/FEDER, UE to C.L.-F. T.M.-B. is also supported by a U01 MH106874 grant and Howard Hughes International Early Career and CERCA Programme (Generalitat de Catalunya). A.A. is partially supported by the Strategic Funding UID/Multi/04423/2019 through national funds provided by the Portuguese Foundation for Science and Technology (FCT) and the European Regional Development Fund —program PT2020 , by the European Structural and Investment Funds —Competitiveness and Internationalization Operational Program-COMPETE 2020, and by National Funds through the FCT under the project PTDC/CTA-AMB/31774/2017(POCI-01-0145-FEDER/031774/2017 ).
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- 2019
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9. Genomic trajectories of a near-extinction event in the Chatham Island black robin
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von Seth, Johanna, Tom, van der Valk, Lord, Edana, Hanna, Sigeman, Remi-André, Olsen, Michael, Knapp, Olga, Kardailsky, Fiona, Robertson, Marie, Hale, Dave, Houston, Euan, Kennedy, Dalén, Love, Norén, Karin, Melanie, Massaro, Bruce C., Robertson, Dussex, Nicolas, von Seth, Johanna, Tom, van der Valk, Lord, Edana, Hanna, Sigeman, Remi-André, Olsen, Michael, Knapp, Olga, Kardailsky, Fiona, Robertson, Marie, Hale, Dave, Houston, Euan, Kennedy, Dalén, Love, Norén, Karin, Melanie, Massaro, Bruce C., Robertson, and Dussex, Nicolas
10. 3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer
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Pere Llinàs-Arias, Miquel Ensenyat-Méndez, Javier I. J. Orozco, Sandra Íñiguez-Muñoz, Betsy Valdez, Chuan Wang, Anja Mezger, Eunkyoung Choi, Yan Zhou Tran, Liqun Yao, Franziska Bonath, Remi-André Olsen, Mattias Ormestad, Manel Esteller, Mathieu Lupien, and Diego M. Marzese
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Epigenetic profiling ,Chromatin accessibility ,Long-range interactions ,RNA levels ,ATAC-seq ,Hi-C ,Genetics ,QH426-470 - Abstract
Abstract Objectives Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Unlike other breast cancer subtypes, the scarcity of specific therapies and greater frequencies of distant metastases contribute to its aggressiveness. We aimed to find epigenetic changes that aid in the understanding of the dissemination process of these cancers. Data description Using CRISPR/Cas9, our experimental approach led us to identify and disrupt an insulator element, IE8, whose activity seemed relevant for cell invasion. The experiments were performed in two well-established TNBC cellular models, the MDA-MB-231 and the MDA-MB-436. To gain insights into the underlying molecular mechanisms of TNBC invasion ability, we generated and characterized high-resolution chromatin interaction (Hi-C) and chromatin accessibility (ATAC-seq) maps in both cell models and complemented these datasets with gene expression profiling (RNA-seq) in MDA-MB-231, the cell line that showed more significant changes in chromatin accessibility. Altogether, our data provide a comprehensive resource for understanding the spatial organization of the genome in TNBC cells, which may contribute to accelerating the discovery of TNBC-specific alterations triggering advances for this devastating disease.
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- 2023
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11. Population dynamics and demographic history of Eurasian collared lemmings
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Edana Lord, Aurelio Marangoni, Mateusz Baca, Danijela Popović, Anna V. Goropashnaya, John R. Stewart, Monika V. Knul, Pierre Noiret, Mietje Germonpré, Elodie-Laure Jimenez, Natalia I. Abramson, Sergey Vartanyan, Stefan Prost, Nickolay G. Smirnov, Elena A. Kuzmina, Remi-André Olsen, Vadim B. Fedorov, and Love Dalén
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Collared lemming ,Palaeogenomics ,Demographic history ,Population structure ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract Background Ancient DNA studies suggest that Late Pleistocene climatic changes had a significant effect on population dynamics in Arctic species. The Eurasian collared lemming (Dicrostonyx torquatus) is a keystone species in the Arctic ecosystem. Earlier studies have indicated that past climatic fluctuations were important drivers of past population dynamics in this species. Results Here, we analysed 59 ancient and 54 modern mitogenomes from across Eurasia, along with one modern nuclear genome. Our results suggest population growth and genetic diversification during the early Late Pleistocene, implying that collared lemmings may have experienced a genetic bottleneck during the warm Eemian interglacial. Furthermore, we find multiple temporally structured mitogenome clades during the Late Pleistocene, consistent with earlier results suggesting a dynamic late glacial population history. Finally, we identify a population in northeastern Siberia that maintained genetic diversity and a constant population size at the end of the Pleistocene, suggesting suitable conditions for collared lemmings in this region during the increasing temperatures associated with the onset of the Holocene. Conclusions This study highlights an influence of past warming, in particular the Eemian interglacial, on the evolutionary history of the collared lemming, along with spatiotemporal population structuring throughout the Late Pleistocene.
- Published
- 2022
- Full Text
- View/download PDF
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