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1. Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19

Author

Hobuß, Lisa, Foinquinos, Ariana, Jung, Mira, Kenneweg, Franziska, Xiao, Ke, Wang, Yong, Zimmer, Karina, Remke, Janet, Just, Annette, Nowak, Juliette, Schmidt, Arne, Pich, Andreas, Mazlan, Stephane, Reamon-Buettner, Stella M., Ramos, Gustavo Campos, Frantz, Stefan, Viereck, Janika, Loyer, Xavier, Boulanger, Chantal, Wollert, Kai C., Fiedler, Jan, and Thum, Thomas

Published
2020
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2. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Author

Schimmel, Katharina, Jung, Mira, Foinquinos, Ariana, José, Gorka San, Beaumont, Javier, Bock, Katharina, Grote-Levi, Lea, Xiao, Ke, Bär, Christian, Pfanne, Angelika, Just, Annette, Zimmer, Karina, Ngoy, Soeun, López, Begoña, Ravassa, Susana, Samolovac, Sabine, Janssen-Peters, Heike, Remke, Janet, Scherf, Kristian, Dangwal, Seema, Piccoli, Maria-Teresa, Kleemiss, Felix, Kreutzer, Fabian Philipp, Kenneweg, Franziska, Leonardy, Julia, Hobuß, Lisa, Santer, Laura, Do, Quoc-Tuan, Geffers, Robert, Braesen, Jan Hinrich, Schmitz, Jessica, Brandenberger, Christina, Müller, Dominik N., Wilck, Nicola, Kaever, Volkhard, Bähre, Heike, Batkai, Sandor, Fiedler, Jan, Alexander, Kevin M., Wertheim, Bradley M., Fisch, Sudeshna, Liao, Ronglih, Diez, Javier, González, Arantxa, and Thum, Thomas

Published
2020
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3. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

Author

Bang, Claudia, Batkai, Sandor, Dangwal, Seema, Gupta, Shashi Kumar, Foinquinos, Ariana, Holzmann, Angelika, Just, Annette, Remke, Janet, Zimmer, Karina, Zeug, Andre, Ponimaskin, Evgeni, Schmiedl, Andreas, Yin, Xiaoke, Mayr, Manuel, Halder, Rashi, Fischer, Andre, Engelhardt, Stefan, Wei, Yuanyuan, Schober, Andreas, Fiedler, Jan, and Thum, Thomas

Subjects
MicroRNA -- Properties, Fibroblasts -- Genetic aspects, Heart enlargement -- Diagnosis, Health care industry
Abstract

In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure. Alterations in microRNA (miRNA) levels are associated with dysfunctional gene expression profiles associated with many cardiovascular disease conditions; however, miRNAs have emerged recently as paracrine signaling mediators. Thus, we investigated a potential paracrine miRNA crosstalk between cardiac fibroblasts and cardiomyocytes and found that cardiac fibroblasts secrete miRNA-enriched exosomes. Surprisingly, evaluation of the miRNA content of cardiac fibroblast-derived exosomes revealed a relatively high abundance of many miRNA passenger strands ('star' miRNAs), which normally undergo intracellular degradation. Using confocal imaging and coculture assays, we identified fibroblast exosomal-derived miR-21_3p ([miR-21.sup.*]) as a potent paracrine-acting RNA molecule that induces cardiomyocyte hypertrophy. Proteome profiling identified sorbin and SH3 domain-containing protein 2 (SORBS2) and PDZ and LIM domain 5 (PDLIM5) as [miR-21.sup.*] targets, and silencing SORBS2 or PDLIM5 in cardiomyocytes induced hypertrophy. Pharmacological inhibition of [miR-21.sup.*] in a mouse model of Ang II-induced cardiac hypertrophy attenuated pathology. These findings demonstrate that cardiac fibroblasts secrete star miRNA-enriched exosomes and identify fibroblast-derived [miR-21.sup.*] as a paracrine signaling mediator of cardiomyocyte hypertrophy that has potential as a therapeutic target., Introduction Cardiac remodeling is a hallmark in the progression of many cardiovascular diseases and is characterized by cardiomyocyte hypertrophy and cardiac fibrosis that lead often to heart failure, a major [...]

Published
2014
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5. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease

Author

Hartmann, Dorothee, primary, Fiedler, Jan, additional, Sonnenschein, Kristina, additional, Just, Annette, additional, Pfanne, Angelika, additional, Zimmer, Karina, additional, Remke, Janet, additional, Foinquinos, Ariana, additional, Butzlaff, Malte, additional, Schimmel, Katharina, additional, Maegdefessel, Lars, additional, Hilfiker-Kleiner, Denise, additional, Lachmann, Nico, additional, Schober, Andreas, additional, Froese, Natali, additional, Heineke, Jörg, additional, Bauersachs, Johann, additional, Batkai, Sandor, additional, and Thum, Thomas, additional

Published
2016
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6. Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

Author

Gupta, Shashi Kumar, primary, Foinquinos, Ariana, additional, Thum, Sabrina, additional, Remke, Janet, additional, Zimmer, Karina, additional, Bauters, Christophe, additional, de Groote, Pascal, additional, Boon, Reinier A., additional, de Windt, Leon J., additional, Preissl, Sebastian, additional, Hein, Lutz, additional, Batkai, Sandor, additional, Pinet, Florence, additional, and Thum, Thomas, additional

Published
2016
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7. Long noncoding RNA Chast promotes cardiac remodeling

Author

Viereck, Janika, primary, Kumarswamy, Regalla, additional, Foinquinos, Ariana, additional, Xiao, Ke, additional, Avramopoulos, Petros, additional, Kunz, Meik, additional, Dittrich, Marcus, additional, Maetzig, Tobias, additional, Zimmer, Karina, additional, Remke, Janet, additional, Just, Annette, additional, Fendrich, Jasmin, additional, Scherf, Kristian, additional, Bolesani, Emiliano, additional, Schambach, Axel, additional, Weidemann, Frank, additional, Zweigerdt, Robert, additional, de Windt, Leon J., additional, Engelhardt, Stefan, additional, Dandekar, Thomas, additional, Batkai, Sandor, additional, and Thum, Thomas, additional

Published
2016
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8. MicroRNA-Based Therapy of GATA 2-Deficient Vascular Disease.

Author

Hartmann, Dorothee, Fiedler, Jan, Sonnenschein, Kristina, Just, Annette, Pfanne, Angelika, Zimmer, Karina, Remke, Janet, Foinquinos, Ariana, Butzlaff, Malte, Schimmel, Katharina, Maegdefessel, Lars, Hilfiker-Kleiner, Denise, Lachmann, Nico, Schober, Andreas, Froese, Natali, Heineke, Jörg, Bauersachs, Johann, Batkai, Sandor, and Thum, Thomas

Published
2016
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9. The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

Author

Ucar, Ahmet, primary, Gupta, Shashi K., additional, Fiedler, Jan, additional, Erikci, Erdem, additional, Kardasinski, Michal, additional, Batkai, Sandor, additional, Dangwal, Seema, additional, Kumarswamy, Regalla, additional, Bang, Claudia, additional, Holzmann, Angelika, additional, Remke, Janet, additional, Caprio, Massimiliano, additional, Jentzsch, Claudia, additional, Engelhardt, Stefan, additional, Geisendorf, Sabine, additional, Glas, Carolina, additional, Hofmann, Thomas G., additional, Nessling, Michelle, additional, Richter, Karsten, additional, Schiffer, Mario, additional, Carrier, Lucie, additional, Napp, L. Christian, additional, Bauersachs, Johann, additional, Chowdhury, Kamal, additional, and Thum, Thomas, additional

Published
2012
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10. Long noncoding RNA Chastpromotes cardiac remodeling

Author

Viereck, Janika, Kumarswamy, Regalla, Foinquinos, Ariana, Xiao, Ke, Avramopoulos, Petros, Kunz, Meik, Dittrich, Marcus, Maetzig, Tobias, Zimmer, Karina, Remke, Janet, Just, Annette, Fendrich, Jasmin, Scherf, Kristian, Bolesani, Emiliano, Schambach, Axel, Weidemann, Frank, Zweigerdt, Robert, de Windt, Leon J., Engelhardt, Stefan, Dandekar, Thomas, Batkai, Sandor, and Thum, Thomas

Abstract

Inhibition of the long noncoding RNA Chastprevents pressure overload–induced cardiac remodeling in mice.

Published
2016
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