1. Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets
- Author
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Ohno Summer, Neal Bruce, Mehta Saurabh, Lucero Marilla, Lozano Rafael, Kumar Vishwajeet, Kumar Aarti, Kalter Henry, Joshi Rohina, Hernández Bernardo, Gómez Sara, Flaxman Abraham D, Fawzi Wafaie, Dutta Arup, Dhingra Usha, Das Vinita, Dantzer Emily, Dandona Lalit, Ali Said, Baqui Abdullah, Ahuja Ramesh, Black Robert, Lopez Alan D, Murray Christopher JL, Prasad Rajendra, Praveen Devarsetty, Premji Zul, Ramírez-Villalobos Dolores, Remolador Hazel, Riley Ian, Romero Minerva, Said Mwanaidi, Sanvictores Diozele, Sazawal Sunil, and Tallo Veronica
- Subjects
Verbal autopsy ,VA ,validation ,Philippines ,Tanzania ,India ,Mexico ,gold standard ,cause of death ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems. With a myriad of analytical and data collection approaches, it is essential to create a high quality validation dataset from different populations to evaluate comparative method performance and make recommendations for future verbal autopsy implementation. This study was undertaken to compile a set of strictly defined gold standard deaths for which verbal autopsies were collected to validate the accuracy of different methods of verbal autopsy cause of death assignment. Methods Data collection was implemented in six sites in four countries: Andhra Pradesh, India; Bohol, Philippines; Dar es Salaam, Tanzania; Mexico City, Mexico; Pemba Island, Tanzania; and Uttar Pradesh, India. The Population Health Metrics Research Consortium (PHMRC) developed stringent diagnostic criteria including laboratory, pathology, and medical imaging findings to identify gold standard deaths in health facilities as well as an enhanced verbal autopsy instrument based on World Health Organization (WHO) standards. A cause list was constructed based on the WHO Global Burden of Disease estimates of the leading causes of death, potential to identify unique signs and symptoms, and the likely existence of sufficient medical technology to ascertain gold standard cases. Blinded verbal autopsies were collected on all gold standard deaths. Results Over 12,000 verbal autopsies on deaths with gold standard diagnoses were collected (7,836 adults, 2,075 children, 1,629 neonates, and 1,002 stillbirths). Difficulties in finding sufficient cases to meet gold standard criteria as well as problems with misclassification for certain causes meant that the target list of causes for analysis was reduced to 34 for adults, 21 for children, and 10 for neonates, excluding stillbirths. To ensure strict independence for the validation of methods and assessment of comparative performance, 500 test-train datasets were created from the universe of cases, covering a range of cause-specific compositions. Conclusions This unique, robust validation dataset will allow scholars to evaluate the performance of different verbal autopsy analytic methods as well as instrument design. This dataset can be used to inform the implementation of verbal autopsies to more reliably ascertain cause of death in national health information systems.
- Published
- 2011
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