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522 results on '"Ren, Hai-Tao"'

4. Clinical characteristics of anti-neuronal antibody positive paraneoplastic neurological syndrome related to immune checkpoint inhibitors

Author

ZHANG Le, FAN Si-yuan, REN Hai-tao, XU Yan, BAI Lin, and GUAN Hong-zhi

Subjects
paraneoplastic syndromes, nervous system, immune checkpoint inhibitors (not in mesh), neurons, autoantibodies, drug-related side effects and adverse reactions, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective To analyze the clinical characteristics of anti - neuronal antibody positive paraneoplastic neurological syndrome related to immune checkpoint inhibitors (ICI - PNS). Methods and Results A total of 5 patients with anti - neuronal antibody positive ICI - PNS in Peking Union Medical College Hospital from January 2012 to March 2024 were included. Tumor types included small cell lung cancer (2 cases), malignant melanoma (one case), Hodgkin lymphoma (one case) and cervical cancer (one case). Immune checkpoint inhibitors (ICIs) included programmed death 1 (PD - 1) inhibitors (3 cases), programmed cell death ligand 1 (PD-L1) inhibitors (one case) and bispecific PD-1/cytotoxic T lymphocyte- associated antigen 4 (CTLA -4) inhibitors (one case). All 5 patients presented with high -risk neurologic phenotypes of paraneoplastic neurological syndrome (PNS), of which 4 presented with limbic encephalitis and one presented with rapidly progressive cerebellar syndrome. Anti - neuronal antibodies detected in serum and/or cerebrospinal fluid of patients included anti - Hu, γ - aminobutyric acid receptor type B (GABABR), sex-determining region of Y chromosome-related high mobility group box 1 (SOX1), metabotropic glutamate receptor 5 (mGluR5) and Yo antibodies. Neurological syndromes occurred within 2 weeks after receiving ICIs in 4 patients. The modified Rankin Score (mRS) of 4 patients was 3 at peak of illness, and one patient was 5 at peak of illness. The Common Terminology Criteria for Adverse Events (CTCAE) was grade 3 in all 5 patients. After withdrawal of ICIs and treatment with glucocorticoids and intravenous immunoglobulin (IVIg), the neurological symptoms of the patients were improved. Conclusions High/ intermediate - risk anti - neuronal antibodies are diagnostic markers of ICI - PNS. Evaluation of ICI - PNS clinical phenotypes and CTCAE grading are important for immunotherapy. Discontinuation of ICIs, administration of glucocorticoids and IVIg can improve the prognosis of patients.

Published
2024
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5. Central nervous system aspergillosis

Author

NI Pin-fei, FAN Si-yuan, LI Jia, YOU Hui, ZHAO Da-chun, REN Hai-tao, and GUAN Hong-zhi

Subjects
aspergillosis, central nervous system fungal infections, voriconazole, biopsy, pathology, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background Central nervous system aspergillosis is clinically rare. We present one case of central nervous system aspergillosis diagnosed by pathology, analyze its clinical features, review the literature，and summarize key diagnostic and therapeutic points. Methods and Results The patient, a 50- year-old woman, presented clinically with progressive weakness in limbs, epileptic seizures, and cognitive decline. Systemic inflammation - immune markers and cerebrospinal fluid (CSF) analysis showed no significant abnormalities. Head MRI revealed abnormal signals in both frontal and parietal lobes with patchy and ring-enhancing lesions and meningeal enhancement. Neuropathology suggested vasculitis and brain tissue necrosis with hemorrhage. Periodic acid methenamine staining revealed fungal hyphae with apparent septation and branching at 45° angles. The final diagnosis was central nervous system aspergillosis. Following antifungal and other symptomatic treatments, the patient's symptoms improved, and follow-up brain MRI showed reduction in lesion size. Conclusions Patients with central nervous system aspergillosis may not have a clear underlying immunodeficiency, and clinical manifestations are lack of specificity. CSF may show no inflammatory changes, and metagenomic next-generation sequencing (mNGS) may be negative. Brain biopsy is the primary diagnostic method. Early, adequate and full-course antifungal treatment with voriconazole can improve the prognosis.

Published
2024
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38. Boosted photocatalytic removal of NO using direct Z-scheme UiO-66-NH2/Bi2MoO6 nanoflowers heterojunction: mechanism insight and humidity effect.

Author

Liang, Jiang-Yu-Shan, Ren, Hai-Tao, Labidi, Abdelkader, Zhu, Qiu-Hui, Dong, Qi-Bing, Allam, Ahmed A., Rady, Ahmed, and Wang, Chuan-Yi

Abstract

Copyright of Rare Metals is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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