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13. TG: A Mediator of the Relationship of Serum Uric Acid to Creatinine Ratio and Nonalcoholic Fatty Liver Disease in Non-Obese Patients with Type 2 Diabetes.

Author

Wang, Qing, Liu, Ke, Zhang, Tian, Wang, Ting, Li, Huan, Wang, Chang, Chen, Jinhu, and Ren, Luping

Subjects
NON-alcoholic fatty liver disease, TYPE 2 diabetes, URIC acid, REGRESSION analysis, CREATININE
Abstract

Background: The study estimated the association between NAFLD and SUA/Cr in Chinese non-obese patients with type 2 diabetes mellitus (T2DM) and also investigated mediating effect of TG. Methods: All patients were divided into NAFLD group (n = 420) and non-NAFLD group (n = 347). The differences of biochemical indicators between the two groups were compared. The link between SUA/Cr and other parameters was checked through Spearman correlation analysis. Differences in the incidence rate of NAFLD between SUA/Cr and TG 3 tertile subgroups were tested by chi-squared. To explore the independent influence of SUA/Cr and TG on NAFLD, logistic regression was performed. The predictive value of SUA/Cr and SUA/Cr combined with BMI for NAFLD was analyzed using ROC curves. In addition, to confirm whether TG has a mediating effect on the link of SUA/Cr and NAFLD, we conducted a mediating analysis. Results: NAFLD group had higher SUA/Cr values than individuals without NAFLD (P < 0.01). SUA/Cr was linked with TC and TG (r = 0.081, 0.215 respectively). NAFLD prevalence increased progressively from quartile 1 to quartile 3 of SUA/Cr (44% vs 57% vs 62%). Prevalence of NAFLD increased from quartile 1 to quartile 3 of TG (35.8% vs 58.7% vs 69.9%). Analysis of the logistic regression revealed that SUA/Cr and TG were statistically linked with NAFLD. The ROC curve pointed out that the area under the curve (AUC), sensitivity and specificity of SUA/Cr were 0.59, 0.629 and 0.522, respectively. The AUC, sensitivity and specificity for SUA/Cr combined with BMI were 0.719, 0.644 and 0.677, separately. The mediation analysis showed a statistically direct effect of SUA/Cr on NAFLD (β=0.148, 95% CI: 0.0393, 0.2585). The function of SUA/Cr on NAFLD partially mediated by TG (β=0.1571, 95% CI: 0.0704, 0.2869). Conclusion: SUA/Cr was significantly associated with NAFLD in non-obese T2DM patients, and TG partially mediated this association. SUA/Cr can be applied to predict for NAFLD. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Red Blood Cell Membrane-Camouflaged Polydopamine and Bioactive Glass Composite Nanoformulation for Combined Chemo/Chemodynamic/Photothermal Therapy

Author

Zhang, Junhao, Sun, Yanfang, Ren, Luping, Chen, Lianxu, Nie, Lei, Shavandi, Amin, Yunusov, Khaydar E., Aharodnikau, Uladzislau E., Solomevich, Sergey O., and Jiang, Guohua

Abstract

Combinations of different therapeutic strategies, including chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT), are needed to effectively address evolving drug resistance and the adverse effects of traditional cancer treatment. Herein, a camouflage composite nanoformulation (TCBG@PR), an antitumor agent (tubercidin, Tub) loaded into Cu-doped bioactive glasses (CBGs) and subsequently camouflaged by polydopamine (PDA), and red blood cell membranes (RBCm), was successfully constructed for targeted and synergetic antitumor therapies by combining CT of Tub, CDT of doped copper ions, and PTT of PDA. In addition, the TCBG@PRs composite nanoformulation was camouflaged with a red blood cell membrane (RBCm) to improve biocompatibility, longer blood retention times, and excellent cellular uptake properties. It integrated with long circulation and multimodal synergistic treatment (CT, CDT, and PTT) with the benefit of RBCms to avoid immune clearance for efficient targeted delivery to tumor locations, producing an “all-in-one” nanoplatform. In vivo results showed that the TCBG@PRs composite nanoformulation prolonged blood circulation and improved tumor accumulation. The combination of CT, CDT, and PTT therapies enhanced the antitumor therapeutic activity, and light-triggered drug release reduced systematic toxicity and increased synergistic antitumor effects.

Published
2024
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26. Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice

Author

Wang, Yichao, primary, Zhao, Hang, additional, Yang, Liying, additional, Zhang, He, additional, Yu, Xian, additional, Fei, Wenjie, additional, Zhen, Yunfeng, additional, Gao, Zhe, additional, Chen, Shuchun, additional, and Ren, Luping, additional

Published
2022
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34. The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus

Author

Zhao, Hang, Zhen, Yunfeng, Wang, Zijing, Qi, Licui, Li, Yong, Ren, Luping, and Chen, Shuchun

Subjects
endocrine system diseases, type 2, diabetes mellitus, nutritional and metabolic diseases, 25-hydroxyvitamin D, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], Original Research, glycated hemoglobin
Abstract

Hang Zhao,1 Yunfeng Zhen,1 Zijing Wang,1 Licui Qi,2 Yong Li,3 Luping Ren,1,* Shuchun Chen1,* 1Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei 050051, People’s Republic of China; 2Graduate School of Hebei North University, Zhangjiakou, Hebei 07500, People’s Republic of China; 3Graduate School of North China University of Science and Technology, Caofeidian New Town, Tangshan, Hebei 063210, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuchun ChenEndocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, Hebei 050051, People’s Republic of ChinaEmail guang6701@sina.comLuping RenEndocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, Hebei 050051, People’s Republic of ChinaEmail renluping1122@163.comPurpose: The aims of this study were to determine the relationship between 25-hydroxyvitamin D [25(OH) D]and glycated hemoglobin (HbA1c) levels in male and female patients with type 2 diabetes mellitus (T2DM).Patients and Methods: The participants were adults diagnosed with T2DM recruited from Hebei General Hospital. Patient information and information regarding blood indicators were collected. The subjects were divided into no vitamin D deficiency group [25(OH) D > 20 ng/mL]and vitamin D deficiency group [25(OH) D < 20 ng/mL], and these groups were then further subdivided into male-only or female-only subgroups. And then, the subjects were divided into male group and female group in different 25(OH) D levels.Results: HbA1c levels in the vitamin D deficiency group were significantly higher than those in the no vitamin D deficiency group for all subjects. The same was true for female patients but not for male patients. There was no difference in HbA1c levels between male and female patients with T2DM, regardless of 25(OH) D deficiency. A negative correlation existed between 25(OH) D and HbA1c in all subjects, as well as in the male-only and female-only subgroups. Vitamin D deficiency was associated with high HbA1c levels before and after adjusting for confounding factors in all participants and in the female-only subgroup, but not in the male-only subgroup.Conclusion: This study confirmed that vitamin D deficiency was related with high HbA1c levels in patients with T2DM, and this relationship differs between female and male patients.Keywords: diabetes mellitus, type 2, 25-hydroxyvitamin D, glycated hemoglobin

Published
2020

37. Effects of Glycated Hemoglobin Level on Bone Metabolism Biomarkers in Patients with Type 2 Diabetes Mellitus

Author

Zhao, Hang, Qi, Cuijuan, Zheng, Chong, Gan, Kexin, Ren, Luping, and Song, Guangyao

Subjects
diabetes mellitus type 2, endocrine system diseases, nutritional and metabolic diseases, bone metabolism, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], Original Research, glycated hemoglobin
Abstract

Hang Zhao,1 Cuijuan Qi,1 Chong Zheng,2 Kexin Gan,1 Luping Ren,1,* Guangyao Song1,* 1Endocrinology Department, Hebei General Hospital, Hebei 050051, People’s Republic of China; 2Pediatric Orthopaedics, Shijiazhuang the Third Hospital, Hebei 050011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Luping Ren Email renluping1122@163.comPurpose: We aimed to determine the relationship between the levels of glycated hemoglobin (HbA1c) and biomarkers of bone metabolism in patients with type 2 diabetes mellitus (T2DM), and whether HbA1c independently influences any of these biomarkers.Patients and Methods: A cohort study of 240 patients with T2DM was performed. Serum was obtained and used to measure HbA1c, total cholesterol (TC), triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol (LDL-C), very-low-density lipoprotein-cholesterol, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), total protein, albumin, blood urea nitrogen (BUN), creatinine, serum 25-hydroxyvitamin D (25OHD), osteocalcin (OC), β-C-terminal cross-linked telopeptide of type I collagen (β-CTX), procollagen type 1 N-terminal propeptide (P1NP), or parathyroid hormone (PTH) concentrations. The participants were divided into three study groups according to HbA1c level: < 7%, 7– 9% and ≥ 9%. Chi-square testing and one-way analysis of variance were used to compare groups. The relationships between HbA1c and bone metabolism biomarker values were analyzed using linear correlation analysis and multiple linear regression analysis.Results: Age, duration of T2DM, and the concentrations of TC, LDL-C, apolipoprotein B, albumin, and BUN showed significant difference among the < 7%, 7– 9% and ≥ 9% HbA1c groups. Of the bone metabolism biomarkers, there were significant differences in serum 25-hydroxyvitamin D (25OHD) and osteocalcin (OC) among the groups. The correlation coefficients (r) for the relationships of HbA1c with 25OHD and OC were − 0.200 and − 0.183, respectively (P < 0.05). Regardless of adjustment for none, some, or all of the confounding factors (age, sex, and duration of T2DM), the 25OHD and OC concentrations were significantly lower in the HbA1c ≥ 9% group than in the HbA1c < 7% group. HbA1c showed no relationship with β-CTX, PINP, or PTH.Conclusion: T2DM patients with poorer glycemic control had lower concentrations of serum 25OHD and OC, suggesting that HbA1c is an independent risk factor for low 25OHD and OC.Keywords: diabetes mellitus type 2, bone metabolism, glycated hemoglobin

Published
2020

46. Polycystic Ovary Syndrome is Associated with Elevated Periostin Levels.

Author

Chen, Xinwei, Huo, Lijing, Ren, Luping, Li, Yali, Sun, Yanmei, Li, Yang, Zhang, Pu, Chen, Shuchun, and Song, Guang-yao

Subjects
POLYCYSTIC ovary syndrome, PERIOSTIN, EXTRACELLULAR matrix proteins, GLUCOSE metabolism disorders, WAIST-hip ratio
Abstract

Purpose Periostin is a secreted extracellular matrix protein that is strongly associated with triglyceride metabolism, chronic inflammation, and insulin resistance. Growing evidence suggests that there is a link between periostin and ovarian function. Our aim was to ascertain whether circulating periostin levels are altered in women with polycystic ovary syndrome (PCOS) and to further explore the relationship between periostin and glucose metabolism disorder in PCOS patients. Methods In total, 50 women with PCOS and 30 age-matched controls without PCOS were recruited for this cross-sectional study. Periostin levels were measured using ELISA as well. Results Circulating periostin levels were significantly elevated in PCOS women compared with controls [4206.75(222.00, 4815.25) vs. 430.75(142. 13, 730.86) ng/ml, P=0. 005]. Spearman's correlation analysis showed that serum periostin levels had a positive correlation with body mass index (BMI), uric acid, homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitive C reactive protein (hs-CRP), and a negative correlation with insulin sensitivity index (ISI). Logistic regression models revealed that PCOS was correlated with waist to hip ratio (WHR), fasting blood glucose (FBG), and periostin levels. In addition, multivariate linear regression analyses showed that FBG, HOMA-IR, and the lipid accumulation index (LAP) were independent factors influencing serum periostin levels. Conclusion PCOS is associated with elevated levels of periostin. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Investigation of early change of endothelial function and related factors in individuals with hyperglycemia

Author

Ren Luping, Hu Liye, Song guangyao, and Zhu LvYun

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Blood Pressure, Type 2 diabetes, Impaired glucose tolerance, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Medicine, Pulse wave velocity, Adiponectin, business.industry, Endothelins, General Medicine, Middle Aged, medicine.disease, Pulse pressure, Postprandial, Blood pressure, Hyperglycemia, cardiovascular system, Female, Endothelium, Vascular, business
Abstract

Objective To evaluate early change of endothelial function by color Doppler ultrasound and pulse wave velocity in hyperglycemia people, and probe the effect of related factors. Methods From March to December 2009, 115 subjects (40 subjects with type 2 diabetes, 45 subjects with impaired glucose tolerance and 30 healthy individuals) aged 35–45 without cardio-cerebral-vascular disease and other disease were recruited into the study. Height, weight, blood pressure were measured, and fasting blood glucose, postprandial blood glucose, adiponectin, endothelin and lipid profile were tested. Then, pulse wave velocity and color Doppler ultrasound test was processed in all subjects. Results The abnormality of pulse wave velocity and endothelium-dependent dilatation was found both in impaired glucose tolerance stage and early stage of type 2 diabetes. Systolic blood pressure, pulse pressure, endothelin, fasting blood glucose and postprandial blood glucose were positively correlated with pulse wave velocity and endothelium-dependent dilatation. Whereas, adiponetin was negatively correlated with pulse wave velocity and endothelium-dependent dilatation. Conclusion Endothelial dysfunction exits in individuals with impaired glucose tolerance as well as in type 2 diabetes. Pulse wave velocity and endothelium-dependent dilatation are associated with adiponectin and endothelin.

Published
2011

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