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24. Latest developments in the upconversion nanotechnology for the rapid detection of food safety: A review

Author

Ji Guangna, Wang Yu, Qin Yingkai, Peng Yuan, Li Shuang, Han Dianpeng, Ren Shuyue, Qin Kang, Li Sen, Gao Zhixian, and Han Tie

Subjects
food safety, upconversion nanoparticles, rapid detection, sensors, surface modification, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801
Abstract

Food safety has become a topic of global concern in the recent decades. The significant food safety incidents occur from time to time around the world, seriously threatening the public health and causing extensive economic losses. In particular, the occurrence of COVID-19 highlights the importance of the food safety for the public health. Therefore, there is an urgent need to establish a fast, simple, sensitive, and efficient method for the detection of food safety. In recent years, the upconversion (UC) nanotechnology has been widely used in the field of food detection. The UC fluorescence analysis technology possesses the advantages of ultra-sensitivity detection, non-invasiveness, light stability, etc., and has broad application prospects in the field of food safety. After cladding and surface modification, it can be combined with other substances through a variety of mechanisms, such as electrostatic interaction, thereby expanding its application in the food safety detection. Thus, overall, there is a vital need to evaluate and utilize the potential of UC nanoparticles in the field of rapid detection of food safety.

Published
2022
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29. Characteristics, Controlling Factors and Reservoir Quality Implications of Inner Fracture Zones in Buried Hills of Archean Covered Metamorphic Rock in Block 13-2, Bozhong Depression

Author

Lu, Junjie, primary, Shan, Xuanlong, additional, Yi, Jian, additional, Li, Huiyong, additional, Xu, Peng, additional, Hao, Guoli, additional, Li, Ang, additional, Yin, Shuai, additional, Ren, Shuyue, additional, Liu, Chaoyang, additional, and Shi, Yunqian, additional

Published
2024
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46. Application of DNA‐fueled molecular machines in food safety testing.

Author

Ma, Yujing, Chen, Ruipeng, Zhang, Rui, Liang, Jun, Ren, Shuyue, and Gao, Zhixian

Abstract

Food is consumed by humans, which is indispensable to human life. Therefore, considerable attention of the whole society has been paid to food safety. Over the last few years, dramatic social development has brought new challenges to food safety, making developing new and quick methods for on‐site food safety testing an important necessity. As a result, DNA‐fueled molecular machines, characterized by high efficiency, accuracy, and sensitivity in testing, have come into the spotlight, based on which sensors can be constructed to detect toxic and harmful substances in food products. This study reviewed recent research on several DNA‐fueled molecular machines, including DNA tweezers, DNA walkers, and DNA origami, for rapidly detecting toxic and harmful substances. Based on the above studies, the sensitivity and timeliness of several DNA molecular machines were summarized and compared, and the development prospect of DNA fuel molecular machines in the field of food safety detection was prospected. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Gynecologic Serous Carcinoma: An Immunohistochemical Analysis of Malignant Body Fluid Specimens

Author

Ren, Shuyue and Klump, William

Subjects
Ventana Medical Systems Inc., Medical equipment industry, Carcinoma, Antibodies, EDTA, Germinoma, Ascites, Cancer, Tumors, Diagnostic errors, Health
Abstract

* Context.--Evaluation of fluid specimens involved by serous carcinoma might potentially include PAX8, GATA3, Uroplakin II, SOX2, and SALL4 antibodies. Those markers are commonly employed for diagnosing carcinomas of various types, including urothelial malignancies and germ cell tumors. There have been no comprehensive immuno-histochemical studies, to our knowledge, for those markers on fluid specimens involved by serous carcinoma. Objective.--To evaluate immunohistochemical markers PAX8, GATA3, SOX2, uroplakin II, and SALL4 in the diagnosis of high-grade serous carcinoma in fluid specimens. Design.--We examined 113 fluids (96 ascites specimens and 17 pleural fluid specimens) that were positive for carcinoma. Most (94 cases; 83.2%) consisted of high-grade serous carcinoma of Mullerian origin. Nineteen cases of non-high-grade serous carcinoma (including one case of low-grade serous carcinoma) of gynecologic origin were also included as anecdotal data. Results.--In 113 fluid specimens with positive results for carcinoma, including nonserous types, 99 (87.6%) had positive results for PAX8, 19 (16.8%) for GATA3; 19 (16.8%) for SOX2, 23 (20.4%) for uroplakin II, and 8 (7.1%) for SALL4. Of 94 fluids (83.2%) involved with high-grade serous carcinoma, 84 (89.4%) had positive results for PAX8, 18 (19.1%) for GATA3, 17 (18.1%) for SOX2, 22 (23.4%) for uroplakin II, and 8 (8.5%) for SALL4. Some of these specimens showed reactivity for more than one immunohistochemical marker. Conclusions.--Most fluids involving high-grade serous carcinoma showed positive results for PAX8, and some cases expressed GATA3, SOX2, uroplakin II, and SALL4. Serous carcinoma in fluids may be positive for immuno-histochemical markers not thought of traditionally as associated with gynecologic malignancy, an important consideration in avoiding misdiagnosis. doi: 10.5858/arpa.2017-0260-OA, About 225 000 new ovarian carcinomas are diagnosed annually, with 140 000 related deaths worldwide. (1) Of all patients with ovarian carcinoma, 69% will succumb to their disease, as compared [...]

Published
2019
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