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30 results on '"Ren, Xian-Yue"'

6. Data from Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma

Author

Jiang, Wei, primary, Liu, Na, primary, Chen, Xiao-Zhong, primary, Sun, Ying, primary, Li, Bin, primary, Ren, Xian-Yue, primary, Qin, Wei-Feng, primary, Jiang, Ning, primary, Xu, Ya-Fei, primary, Li, Ying-Qin, primary, Ren, Jian, primary, Cho, William CS, primary, Yun, Jing-Ping, primary, Zeng, Jing, primary, Liu, Li-Zhi, primary, Li, Li, primary, Guo, Ying, primary, Mai, Hai-Qiang, primary, Zeng, Mu-Sheng, primary, Kang, Tie-Bang, primary, Jia, Wei-Hua, primary, Shao, Jian-Yong, primary, and Ma, Jun, primary

Published
2023
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9. Supplementary Tables S1-S7 and Supplementary Figure Legends from Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma

Author

Jiang, Wei, primary, Liu, Na, primary, Chen, Xiao-Zhong, primary, Sun, Ying, primary, Li, Bin, primary, Ren, Xian-Yue, primary, Qin, Wei-Feng, primary, Jiang, Ning, primary, Xu, Ya-Fei, primary, Li, Ying-Qin, primary, Ren, Jian, primary, Cho, William CS, primary, Yun, Jing-Ping, primary, Zeng, Jing, primary, Liu, Li-Zhi, primary, Li, Li, primary, Guo, Ying, primary, Mai, Hai-Qiang, primary, Zeng, Mu-Sheng, primary, Kang, Tie-Bang, primary, Jia, Wei-Hua, primary, Shao, Jian-Yong, primary, and Ma, Jun, primary

Published
2023
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12. Supplimentary Figure S2: Kaplan-Meier curves estimation of DFS and OS for patients with high or low methylation levels stratified by tumor stage or the receipt of concurrent chemotherapy from Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma

Author

Jiang, Wei, primary, Liu, Na, primary, Chen, Xiao-Zhong, primary, Sun, Ying, primary, Li, Bin, primary, Ren, Xian-Yue, primary, Qin, Wei-Feng, primary, Jiang, Ning, primary, Xu, Ya-Fei, primary, Li, Ying-Qin, primary, Ren, Jian, primary, Cho, William CS, primary, Yun, Jing-Ping, primary, Zeng, Jing, primary, Liu, Li-Zhi, primary, Li, Li, primary, Guo, Ying, primary, Mai, Hai-Qiang, primary, Zeng, Mu-Sheng, primary, Kang, Tie-Bang, primary, Jia, Wei-Hua, primary, Shao, Jian-Yong, primary, and Ma, Jun, primary

Published
2023
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13. Supplementary Figure S1: Representative Pyrograms of Methylation Analysis by Bisulfite Pyrosequencing. from Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma

Author

Jiang, Wei, primary, Liu, Na, primary, Chen, Xiao-Zhong, primary, Sun, Ying, primary, Li, Bin, primary, Ren, Xian-Yue, primary, Qin, Wei-Feng, primary, Jiang, Ning, primary, Xu, Ya-Fei, primary, Li, Ying-Qin, primary, Ren, Jian, primary, Cho, William CS, primary, Yun, Jing-Ping, primary, Zeng, Jing, primary, Liu, Li-Zhi, primary, Li, Li, primary, Guo, Ying, primary, Mai, Hai-Qiang, primary, Zeng, Mu-Sheng, primary, Kang, Tie-Bang, primary, Jia, Wei-Hua, primary, Shao, Jian-Yong, primary, and Ma, Jun, primary

Published
2023
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14. Supplementary Table S5: Differentially Methylated CpG Sites (2173 Sites) in 24 NPC and 24 NCNBT from Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma

Author

Jiang, Wei, primary, Liu, Na, primary, Chen, Xiao-Zhong, primary, Sun, Ying, primary, Li, Bin, primary, Ren, Xian-Yue, primary, Qin, Wei-Feng, primary, Jiang, Ning, primary, Xu, Ya-Fei, primary, Li, Ying-Qin, primary, Ren, Jian, primary, Cho, William CS, primary, Yun, Jing-Ping, primary, Zeng, Jing, primary, Liu, Li-Zhi, primary, Li, Li, primary, Guo, Ying, primary, Mai, Hai-Qiang, primary, Zeng, Mu-Sheng, primary, Kang, Tie-Bang, primary, Jia, Wei-Hua, primary, Shao, Jian-Yong, primary, and Ma, Jun, primary

Published
2023
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18. Comprehensive Characterization of Immune Landscape Based on Epithelial-Mesenchymal Transition Signature in OSCC: Implication for Prognosis and Immunotherapy

Author

Zhang, Si-yuan, primary, Ren, Xian-yue, additional, Wang, Chun-yang, additional, Chen, Xi-juan, additional, Cao, Ruo-yan, additional, Liu, Qin, additional, Pan, Xue, additional, Zhou, Jia-ying, additional, Zhang, Wei-lin, additional, Tang, Xin-Ran, additional, Cheng, Bin, additional, and Wu, Tong, additional

Published
2021
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23. Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma

Author

Jiang, Wei, primary, Liu, Na, additional, Chen, Xiao-Zhong, additional, Sun, Ying, additional, Li, Bin, additional, Ren, Xian-Yue, additional, Qin, Wei-Feng, additional, Jiang, Ning, additional, Xu, Ya-Fei, additional, Li, Ying-Qin, additional, Ren, Jian, additional, Cho, William CS, additional, Yun, Jing-Ping, additional, Zeng, Jing, additional, Liu, Li-Zhi, additional, Li, Li, additional, Guo, Ying, additional, Mai, Hai-Qiang, additional, Zeng, Mu-Sheng, additional, Kang, Tie-Bang, additional, Jia, Wei-Hua, additional, Shao, Jian-Yong, additional, and Ma, Jun, additional

Published
2015
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28. Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth

Author

Liu, Na, primary, He, Qing-Mei, additional, Chen, Jie-Wei, additional, Li, Ying-Qin, additional, Xu, Ya-Fei, additional, Ren, Xian-Yue, additional, Sun, Ying, additional, Mai, Hai-Qiang, additional, Shao, Jian-Yong, additional, Jia, Wei-Hua, additional, Kang, Tie-Bang, additional, Zeng, Mu-Sheng, additional, and Ma, Jun, additional

Published
2014
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29. TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma.

Author

Wen, Xin, Li, Ying-Qing, Zhang, Jian, He, Qing-Mei, Yang, Xiao-Jing, Tang, Xin-Ran, Wang, Ya-Qin, Zhang, Pan-Pan, Ma, Jun, Liu, Na, Ren, Xian-Yue, Cheng, Bin, and Chen, Xiao-Zhong

Subjects
DNA methylation, NASOPHARYNX cancer, TUMOR necrosis factors, BIOLOGICAL tags, MESSENGER RNA
Abstract

Background: Increasing evidence recognizes that DNA methylation abnormalities play critical roles in cancer development. Our previous genome-wide methylation profile showed that tumor necrosis factor-alpha-induced protein 8 like 3 (TIPE3) was hypermethylated in nasopharyngeal carcinoma (NPC). However, the relationship between TIPE3 methylation and its mRNA expression, as well as its biological roles in NPC are unknown. Methods: Bisulfite pyrosequencing and quantitative RT-PCR were performed to quantify the TIPE3 methylation and expression levels. Kaplan-Meier curves and Cox regression analysis were used to estimate the correlation between TIPE3 methylation levels and survival in two patient cohorts collected from two hospitals (n = 441). The MTT, colony formation, Transwell migration and invasion assays, and xenograft tumor growth and lung metastatic colonization models were used to identify the functions of TIPE3 on NPC cells. Results: We found that TIPE3 CpG island (CGI) was hypermethylated and its mRNA levels were downregulated in many cancers, including NPC. TIPE3 downregulation was associated with its CGI hypermethylation. Furthermore, NPC patients with high TIPE3 CGI methylation levels had poorer clinical outcomes than those with low methylation levels. The TIPE3 CGI methylation level was an independent prognostic factor. Moreover, restoring TIPE3 expression significantly inhibited NPC cell proliferation, migration and invasion in vitro, and suppressed tumor growth and lung metastatic colonization in vivo, while silencing TIPE3 acted in an opposite way. Conclusions: TIPE3 downregulation correlates with its CGI hypermethylation in several solid cancers. TIPE3 acts as a tumor suppressor in NPC, providing a further insight into NPC progression and representing a potential prognostic biomarker for NPC. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Immune Landscape of the B7 and TNFR Families in Oral Squamous Cell Carcinoma.

Author

Ren XY, Chen XJ, Chen XB, Wang CY, Liu Q, Pan X, Zhang SY, Zhang WL, and Cheng B

Subjects
B7 Antigens, Humans, Carcinoma, Squamous Cell, Mouth Neoplasms
Abstract

Objective: To understand the immune molecular landscapes of the two major costimulatory and coinhibitory pathways (B7 and TNFR families) in oral squamous cell carcinoma., Methods: The B7 family members (CD80, CD86, CD274, ICOSLG, CD276, VTCN1, NCR3LG1, HHLA2 and PDCD1LG2) and TNFR family members (TNFSF4, CD40, CD70, TNFSF9, TNFRSF14 and TNFSF18) were used to analyse the costimulatory and coinhibitory pathway alterations in oral squamous cell carcinoma. The online tools UCSC Xena and cBioPortal were used to derive oral squamous cell carcinoma patients' clinical parameters, mRNA levels, mutations, DNA copy number alterations and methylation levels. The correlations between mRNA levels and methylation levels were determined using Spearman's correlation analysis. A Kaplan-Meier survival analysis was performed to examine the relationships between mRNA expression levels and overall survival., Results: Compared with normal oral epithelial tissues, approximately 23.1% of patients showed upregulation of B7 expression and 15.3% showed upregulation of TNFR expression in oral squamous cell carcinoma, with CD274 (PD-L1) upregulation being the most common alteration. Mutations and copy number alterations were shown to have little effect on B7 and TNFR expression. The mRNA levels of B7 and TNFR genes were negatively correlated with their methylation levels. Furthermore, oral squamous cell carcinoma patients with high expression levels of CD274 showed poor overall survival, while those with high expression levels of CD276 or HHLA2 showed good clinical outcomes., Conclusion: This study elucidated the molecular landscapes of the B7 and TNFR genes in oral squamous cell carcinoma, which could provide a novel strategy for clinical therapy.

Published
2020
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