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287 results on '"Ren Wenzhi"'

1. Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy

Author

Wang Qiuye, Cui Haijing, Gan Ning, Ma Xuehua, Ren Wenzhi, and Wu Aiguo

Subjects
matrix metalloproteinases, enzyme-responsive, cancer, diagnosis, therapy, Chemistry, QD1-999
Abstract

Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately designed enzyme-responsive nanoprobes, which is expected to realize precise diagnosis and treatment of cancer. This review systematically summarizes the classifications of MMPs, their substrates and recognized sequences, and overexpressed tumor types. The advances of MMPs-responsive nanoprobes for cancer diagnosis and therapy are focused, including trigger mechanism, design principle, and various imaging or therapy modes. Finally, this review analyzes the challenges of MMPs-responsive nanoprobes in clinical application, and provides constructive opinions for future study.

Published
2022
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2. Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

Author

Zeng, Yuan, Zhang, Shuhan, Guo, Yuecong, Cong, Yalin, Ding, Xu, Li, Peihua, Lin, Yunxiang, Ren, Wenzhi, Su, Hui, Sun, Weigang, Xu, Liuxin, Zhang, Guikai, Chen, Shihua, Chen, Yu, Cheng, Weiren, Chu, Shengqi, Guan, Yong, Han, Jinru, Lin, Jie, Liu, Hengjie, Liu, Zheyi, Luo, Pan, Meng, Fanchun, Qiao, Sicong, Song, Zongyin, Wang, Ying, Wu, Zhao, Yang, Chenyu, Yang, Meng, Yang, Shirui, Yin, Zi, Yin, Zhibin, Zhang, Pengjun, Zhang, Hongyu, Zheng, Pingping, Zhou, Jia, Zhou, Wanlin, An, Pengfei, Cheng, He, Fan, Chunhai, Huang, Xingjiu, Lei, Yong, Li, Lina, Li, Mu, Liu, Qinghua, Peng, Shuming, Song, Li, Sun, Zhihu, Tian, Yangchao, Wang, Fangjun, Wang, Lihua, Wang, Liming, Wei, Shiqiang, Wu, Aiguo, Xiao, Chunlei, Yang, Xueming, Yin, Panchao, Zhang, Jing, Zhang, Mingxin, Wang, Yaling, and Chen, Chunying

Published
2024
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12. Vomiting and wasting disease associated with hemagglutinating encephalomyelitis viruses infection in piglets in jilin, china

Author

Li Zhiping, Chen Keyan, Lu Huijun, Song Deguang, Ren Wenzhi, Du Chongtao, Zhao Chuanbo, Zhao Kui, Gao Wei, Lan Yungang, Xie Shengnan, He Wenqi, and Gao Feng

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract One coronavirus strain was isolated from brain tissues of ten piglets with evident clinical manifestations of vomiting, diarrhea and dyskinesia in Jilin province in China. Antigenic and genomic characterizations of the virus (isolate PHEV-JLsp09) were based on multiplex PCR and negative staining electron microscopy and sequence analysis of the Hemagglutinin-esterase (HE) gene. These piglets were diagnosed with Porcine hemagglutinating encephalomyelitis virus (PHEV). Necropsy was performed on the piglets. Major pathological changes included meningeal hyperemia, meningeal hemorrhage and cortical hemorrhage. Minor changes were also observed in other organs. Histopathological changes included satellitosis and neuronophagia in the cerebral cortex. Mice were infected with the isolated virus. Their histopathological changes were similar to those symptoms observed in the piglets, exhibiting typical changes for non-suppurative encephalitis. Thus, Porcine hemagglutinating encephalomyelitis virus mainly causes damage to the nervous system but also impacts other organs. This viral strain (isolate PHEV-JLsp09) found in the Siping area of Jilin Province in China is evolutionally closest to the HEV-67N stain (North American strain), indicating that this viral strain evolved from the PHEV from North America.

Published
2011
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13. Identification of NCAM that interacts with the PHE-CoV spike protein

Author

Chen Keyan, Du Chongtao, Ren Wenzhi, Lu Huijun, Zhao Kui, He Wenqi, Gao Wei, Lan Yungang, Song Deguang, and Gao Feng

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The spike proteins of coronaviruses associate with cellular molecules to mediate infection of their target cells. The characterization of cellular proteins required for virus infection is essential for understanding viral life cycles and may provide cellular targets for antiviral therapies. Results We identified Neural Cell Adhesion Molecule (NCAM) as a novel interacting partner of the PHE-CoV S protein. A T7 phage display cDNA library from N2a cells was constructed, and the library was screened with the soluble PHE-CoV S glycoproteins. We used a coimmunoprecipitation assay to show that only the NCAM was a binding partner of spike protein. We found that a soluble form of anti-NCAM antibody blocked association of the PHE-CoV with N2a cells. Furthermore, double-stranded siRNA targeted against NCAM inhibited PHE-CoV infection. Conclusions A novel interaction was identified between NCAM and spike protein and this association is critical during PHE-CoV infection.

Published
2010
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44. First deliveries of felines by transcervical transfer of in vitro-cultured embryos

Author

Li, Hui, Wang, Ning, You, Rongjing, Yin, Shen, Yuan, Bao, Chen, Jian, Ren, Wenzhi, Liang, Shuang, and Zhao, Minghui

Subjects
Blastocyst, Food Animals, Equine, Cats, Animals, Animal Science and Zoology, Female, Fertilization in Vitro, Small Animals, Embryo Transfer, Culture Media
Abstract

Transcervical transplantation of embryos has been wildly used in several species. However, it has not been successful in feline species because of their unique cervix structure combined with poor in vitro culture systems for embryos. In the present study, a simple device to guide the embryo transfer (ET) tube through the cervix and into the uterus was developed. To supply better blastocysts for ET, the in vitro culture system of feline embryos was also optimized. Results showed that 91.67 ± 4.17% of embryos developed to the blastocyst stage in QAU-4 medium compared with 49.17 ± 6.51% in KSOM medium. The total cell number of blastocysts reached 87.1 ± 22.1 in QAU-4 medium compared with 29.8 ± 2.1 in KSOM. Embryoid body formation was also observed in QAU-4 medium. Finally, by the improved technical scheme, CRX (Cone-Rod Homeobox) gene-edited kittens were successfully bred. To date, this is the first report, to our knowledge, of knockout kittens successfully delivered after transcervical ET with a simple transfer tube.

Published
2022

46. Multiple valence states of Fe boosting SERS activity of Fe3O4 nanoparticles and enabling effective SERS-MRI bimodal cancer imaging

Author

Lin, Jie, primary, Ma, Xuehua, additional, Li, Anran, additional, Akakuru, Ozioma Udochukwu, additional, Pan, Chunshu, additional, He, Meng, additional, Yao, Chenyang, additional, Ren, Wenzhi, additional, Li, Yanying, additional, Zhang, Dinghu, additional, Cao, Yi, additional, Chen, Tianxiang, additional, and Wu, Aiguo, additional

Published
2022
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47. Additional file 1 of IGF1 receptor-targeted black TiO2 nanoprobes for MRI-guided synergetic photothermal-chemotherapy in drug resistant pancreatic tumor

Author

Xu, Kaiwei, Jin, Lufei, Xu, Liu, Zhu, Yuchao, Hong, Lu, Pan, Chunshu, Li, Yanying, Yao, Junlie, Zou, Ruifen, Tang, Weiwei, Wang, Jianhua, Wu, Aiguo, and Ren, Wenzhi

Subjects
endocrine system diseases
Abstract

Additional file 1: Figure S1. PH and NIR co-responded drug-release of bTiO2-Gd-IGF1-GEM. Figure S2. The IGF1R expression in MIA PaCa-2 cells, hTERT-HPNE cells, BxPC-3 cells, and Panc-2 cells. Figure S3. Live/dead cell staining following various treatments. Green and red fluorescence denote live and dead cells, respectively. Scale bar is 20 μm. Figure S4. In vivo toxicity analysis of nanoprobes on balb/c mice. The changes of (a) body weight, (b) routine blood indexes, and (c) organ histological analysis after injected with PBS, bTiO2-Gd-COOH, bTiO2-Gd-IGF1 for 1 month. Scale bar is 100 μm.

Published
2022
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50. Ginsenoside Rk1-Loaded Manganese-Doped Hollow Titania for Enhancing Tumor Sonodynamic Therapy viaUpregulation of Intracellular Reactive Oxygen Species

Author

Yang, Ming, Ren, Wenzhi, Cui, Haijing, Qin, Qiongyu, Wang, Qiuye, Zhu, Weihao, Wu, Xiaoxia, Pan, Chunshu, Qi, Xiaopeng, and Wu, Aiguo

Abstract

Amplifying the intracellular reactive oxygen species (ROS) level remains an urgent challenge for efficient sonodynamic therapy (SDT) of tumors. Herein, by loading ginsenoside Rk1 with manganese-doped hollow titania (MHT), a Rk1@MHT sonosensitizer was conceived to strengthen the outcome of tumor SDT. The results verify that manganese-doping remarkably elevates the UV–visible absorption and decreases the bandgap energy of titania from 3.2 to 3.0 eV, which improves ROS production under ultrasonic irradiation. Immunofluorescence and Western blot analysis demonstrate that ginsenoside Rk1 can block the critical protein of the glutathione synthesis pathway, glutaminase, thus enhancing intracellular ROS by eliminating the endogenous glutathione-depleted pathway of ROS. Manganese-doping confers the nanoprobe T1-weighted MRI function (r2/r1= 1.41). Moreover, the in vivotests confirm that Rk1@MHT-based SDT eradicates liver cancer in tumor-bearing mice viadual upregulation of intracellular ROS production. In summary, our study provides a new strategy for designing high-performance sonosensitizer to achieve noninvasive cancer treatment.

Published
2023
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