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Rarely occurring at birth, crossed renal ectopia is an abnormality in which both kidneys occupy the same side of the body while one ureter - its length based on kidney location - traverses across midline to graft into opposite-side bladder.McDonald and McClellan classified renal ectopia into 4 types.Solitary crossed renal ectopia (SCRE) is an extremely uncommon abnormality of the urinary system. To date, only 35 instances have been documented in published literature. Typically, these cases are detected by chance during patient assessments for related issues such as genitourinary, cardiovascular, hematological or vertebral abnormalities.

Une prise en charge efficace de la lithiase rénale passe par la réalisation d'un bilan métabolique dès le premier épisode de calcul. Malgré son coût moindre et sa mise en place aisée, celui-ci reste peu prescrit. L'objectif de cette revue est de donner les éléments clés pour interpréter facilement et rapidement un bilan métabolique de première intention et de pouvoir détecter les anomalies nécessitant une prise en charge spécialisée. A metabolic evaluation must be carried out from the first episode of stone for effective management of renal lithiasis. Despite its lower cost and accessibility, it remains rarely prescribed. The aim of this publication is to provide keys to easily and quickly interpret a metabolic evaluation and to detect anomalies requiring specialized care. [ABSTRACT FROM AUTHOR]

Incidence and prevalence of urolithiasis is apparently increasing worldwide, also among children and adolescents. Nevertheless, robust data have only been obtained in a few countries. In Spain, a voluntary Registry for Pediatric Renal Lithiasis has been active since 2015. Irregular participation limits its applicability, as well as its limitation to patients with a stone available for morphocompositional study, to obtain data about incidence and prevalence. On the other hand, findings about typology of stones and clinical and analytical characteristics of these subjects have been communicated in several meetings. Other valuable efforts in this field are the elaboration of guidelines for the collection and processing of urine samples for the study of urolithiasis in pediatric patients with the consensus of the Spanish Society for Pediatric Nephrology (AENP) as well as the Spanish Society for Laboratory Medicine (SEQC), the collaborative network RenalTube for the diagnosis of primary tubulopathies and the registry of patients with Primary Hyperoxaluria (OxalSpain). In many hospitals from the public healthcare system, pediatric nephrologists are the specialists in charge of the management of children with kidney stones, but there is no formal regulation on this competence. Other specialists, such as urologists, pediatric surgeons or pediatric urologists, in many cases do not offer a complete insight into the etiopathogenic mechanisms and the consequent medical treatment. Access to medication according to standards of treatment is warranted, provided a correct diagnosis is achieved, but criteria for the reimbursement of certain therapies, such as RNAi drugs for primary hyperoxaluria, are arguable.

Ureteroscopy is recognized as a minimally invasive and readily accessible method with low morbidity, favorable outcomes, and rapid post-interventional recovery. Recent advancements in rigid and flexible ureteroscopes have enhanced their efficiency, durability, and capability to accommodate accessory instruments. In this retrospective analysis, we evaluated 75 consecutive patients with large renal stones (stone burden between 2 and 4 cm) treated using a combination of semirigid and flexible ureteroscopy between January 1, 2020, and December 31, 2021. Stone properties and anatomical information were collected from the image archives derived from computed tomography (CT) and/or KUD radiography. Multiple ureteroscopy sessions were required for bigger stones. The length of the hospital stay, operation time, stone-free rate, preoperative and postoperative complications, and complication rates were examined. The average age of the patients was 52.7 years, with a mean stone burden of 31.45 mm. Most stones were in the renal pelvis, followed by the upper calyx. The average operative time was 56.2 minutes. After the initial ureteroscopy session, the stone clearance rate was 76%, which increased to 92% after two ureteroscopy sessions. Complication rates were evaluated using the Clavien-Dindo modified system, with an overall complication rate of 18.4%. Most of the complications were Clavien Grades I and II, with no grade V complication encountered. Large renal stones can be treated by combining semirigid and flexible ureteroscopy to reduce the operative time and protect the flexible ureteroscope. [ABSTRACT FROM AUTHOR]

Pathological calcifications may consist of calcium oxalate (CaOx), hydroxyapatite (HAP), and brushite (BRU). The objective of this study was to evaluate the effect of phytate (inositol hexakisphosphate, InsP6), InsP6 hydrolysates, and individual lower InsPs (InsP5, InsP4, InsP3, and InsP2) on the crystallization of CaOx, HAP and BRU in artificial urine. All of the lower InsPs seem to inhibit the crystallization of calcium salts in biological fluids, although our in vitro results showed that InsP6 and InsP5 were stronger inhibitors of CaOx crystallization, and InsP5 and InsP4 were stronger inhibitors of BRU crystallization. For the specific in vitro experimental conditions we examined, the InsPs had very weak effects on HAP crystallization, although it is likely that a different mechanism is responsible for HAP crystallization in vivo. For example, calciprotein particles seem to have an important role in the formation of cardiovascular calcifications in vivo. The experimental conditions that we examined partially reproduced the in vivo conditions of CaOx and BRU crystallization, but not the in vivo conditions of HAP crystallization. [ABSTRACT FROM AUTHOR]

Introduction: PCNL remains the gold standard for larger kidney stones. Reducing the operating time of PCNL and its complication rate seems to be the next logical step in optimizing this classical technique. To achieve these objectives, some new methods of lithotripsy emerge. We present the data of a single, high-volume, academic center with combined ultrasonic and ballistic lithotripsy in PCNL using the Swiss LithoClast® Trilogy device. Materials and Methods: We designed a prospective, randomized study including patients who underwent PCNL or miniPerc with lithotripsy using the new EMS Lithoclast Trilogy or EMS Lithoclast Master. The procedure was carried out with all patients in prone position, by the same surgeon. The working channel size was 24 Fr–15.9 Fr. We evaluated the stones' features, operative time, fragmentation time, complications, stone clearance rate and stone-free rate. Results: Our study included 59 patients, 38 females and 31 males, of an average age of 54.5 years old. The Trilogy group included 28 patients and the comparator included 31 patients. Urine culture was positive in seven cases which required seven days of antibiotics. The mean stone diameter was 35.6 mm with a mean Hounsfield unit (HU) of 710.1. The average number of stones was 2.08 (6 complete staghorn stones and 12 partial staghorn stones). A total of 13 patients presented a JJ stent (46.4%). We found a very significant difference in all the parameters favoring the Trilogy device. The most important result in our opinion is the probe active time, which was almost six times shorter in the Trilogy group. The stone clearance rate was about double in the Trilogy group, leading to shorter overall and intra-renal operating times. The overall complication rate was 17.9% in the Trilogy group and 23% in the Lithoclast Master group. The mean hemoglobin drop was 2.1 g/dL with a mean creatinine rise of 0.26 mg/dL. Conclusions: Swiss LithoClast® Trilogy, a device combining ultrasonic and ballistic energy, is a safe and efficient method of lithotripsy for PCNL, proving statistically significant benefits over its predecesor. It can achieve the goal of reducing complication rates and operative times for PCNL. [ABSTRACT FROM AUTHOR]

Objective: The present work aimed to measure the changes in biological markers in patients during and after percutaneous nephrolithotomy (PNL). Methods: A cross-sectional study was performed in patients managed with PLN. Biological markers were measured at three different times. Measures of central tendency and mean difference were used to describe the population and biological markers. A significant value was considered if p < 0.05. Results: A total of 23 patients with a diagnosis of renal lithiasis managed with PNL were included. The sample included 73.9% of woman with a mean age of 47.96 years. About 26% presented some post-surgical complication. Changes observed in the biological markers: hemoglobin and platelet levels showed a tendency to decrease post-surgery (p < 0.05). Leukocyte, neutrophil, and C-reactive protein levels showed a significant increase in the post-operative period. The DHL and erythrocyte sedimentation rate presented elevation during the post-operative period; however, after the surgical event, they decreased. Conclusions: We can assume the degree of metabolic response and establish preventive measures for possible complications. The implementation of protocols with the use of biomarkers can be useful in the identification of risk factors for complications during and after the surgical event. [ABSTRACT FROM AUTHOR]

We describe the case of a 76-year-old woman with a spontaneous nephroduodenal fistula. The patient was initially evaluated for gastrointestinal and urinary symptoms associated with fever and anemia, after which she was admitted with the diagnosis of right chronic pyelonephritis, hydronephrosis, and renal lithiasis. The fistula was diagnosed incidentally by percutaneous pyelography during a right nephrostomy and was later confirmed with an abdominal CT scan. A multidisciplinary decision was made to surgically treat the fistula (right nephrectomy plus duodenal repair); the surgery had a short-term positive outcome. We report a systematic review of the literature related to spontaneous pyeloduodenal fistulæ and their treatments. [ABSTRACT FROM AUTHOR]

Background and objectives: Renal stones are widespread, with a lifetime prevalence of 10% in adults. Flexible ureteroscopy enables urologists to treat lower calyx stones or even complex renal stones through the natural orifice and achieve an acceptable stone-free rate. Hence, we analyzed the effectiveness and safety of FURS versus PCNL in treating renal stones between 20 and 40 mm in diameter. Materials and methods: We retrospectively analyzed 250 consecutive patients with large renal solitary stones (stone burden between 2 and 4 cm) from 1 January 2019 to 31 December 2020. The patients were divided into two groups: group 1 (125 patients), in which the patients were treated by a retrograde flexible ureteroscopic approach, and group 2 (125 patients), in which we used percutaneous nephrolithotomy. Stone characteristics and anatomical data were observed based on the computed tomography (CT) and/or KUB (Kidney-ureter-Bladder) radiography imaging archive. Results: The mean stone burden was 26.38 ± 4.453 mm in group 1 and 29.44 ± 4.817 mm in group 2. The stone-free rate after the first ureteroscopy was higher for the PNL(percutaneous nephrolithotomy) group (90.4%) than the F-URS group (68%). After two sessions of ureteroscopy, the SFR was 88.8% in the first group, and after three procedures, the SFR rose to 95.2%. The overall complication rate was higher in group 1 than in group 2 (18.4% vs. 16.8%), but without statistical relevance (p > 0.5). Furthermore, we encountered more grade III and IV complications in the PNL group (8.8% vs. 4.8%, p < 0.05). Conclusion: Flexible ureteroscopy proves to be efficient in treating renal stones over 2 cm. However, the patients must be informed that more than one procedure might be necessary to overcome the entire stone burden. [ABSTRACT FROM AUTHOR]

Renal lithiasis is a medical condition characterized by the formation of stones, known as stones, in the upper urinary tract. Its most frequent clinical manifestation is nephritic colic, which causes intense and acute pain in the renal area. This pathology is prevalent and affects approximately 10% of the population in non-industrialized areas. The purpose of this review is to exhaustively analyze the diagnosis and the various therapeutic alternatives used to treat renal lithiasis. The approach adopted in this research is qualitative, allowing a deep understanding of the aspects related to the diagnosis and treatment of this condition. Likewise, its scope is descriptive, which allows a detailed analysis of the findings obtained. For the collection of information, the documentary analysis method was used, which involved the review and evaluation of scientific articles and updated books on the subject. The results of this review were encouraging, since it was possible to establish that the diagnosis of renal lithiasis is based on the identification of clinical manifestations, with the support of various tests and procedures. Among them, the use of reactive strips, complete blood counts and the determination of protein C stand out, in addition to the application of imaging techniques such as UroTAC. [ABSTRACT FROM AUTHOR]

Background/Objectives: Basal cell nevus syndrome (BCNS) is an autosomal dominant skin cancer predisposition syndrome associated with abnormal mineral metabolism, a risk factor for urinary stone disease (USD). However, no research investigating the association between BCNS and USD or other manifestations of abnormal mineral metabolism has been conducted. The objective of this study is to investigate the association between BCNS and conditions associated with disordered mineral metabolism including USD, hypothyroidism, and osteoporosis and compare them to prevalence in the general population to elucidate potential unknown manifestations of the condition. Methods: This retrospective study examined medical records of adult and pediatric patients with confirmed BCNS from the Mayo Clinic database from 1 January 1995 to 12 January 2020. Records were surveyed for evidence of USD and other comorbidities potentially related to BCNS. The studied cohort included 100 adult patients and 5 pediatric patients. Results: A total of 105 patients were included in this analysis, 10 of whom experienced confirmed USD, representing a prevalence of 10%. Six adult patients were identified with a diagnosis of osteoporosis, representing a prevalence of 6%. Thirteen adult patients were identified with a diagnosis of hypothyroidism, representing a prevalence of 13%. Conclusions: This study identified a prevalence of USD in BCNS patients comparable to estimates of national prevalence, indicating that known abnormalities in mineral metabolism likely do not increase the incidence of USD in BCNS patients. Additional findings included increased prevalence of hypothyroidism and decreased prevalence of osteoporosis in the BCNS cohort compared to national averages. [ABSTRACT FROM AUTHOR]

Paracellular transport in the kidney is mediated by a family of proteins located in the tight junctions called claudins which confers its ionic selectivity. Claudin-2 is highly expressed in the proximal tubule and descending limb of Henle and mediate paracellular reabsorption of sodium and calcium cations. In the thick ascending limb of Henle (TALH) calcium is reabsorbed by a paracellular channel formed by Claudin-16 and-19. Claudin-16 mediates cationic permeability while Claudin-19 increases the cationic selectivity of Claudin-16 by blocking anionic permeability. On the other hand, Claudin 14, that is also located in TALH, inhibits the paracellular permeability of Claudin-16 to calcium. Recent wide genomic association analysis studies have detected four common synonymous variants (genetic polymorphisms of a single nucleotide, SNPs) at the locus of Claudin-14 gene that were significantly associated with the presence of renal lithiasis. Another study of wide genomic association and nephrolithiasis was carried out in the general population but including chromosome X, where claudin-2 gene is located. They detected nine SNPs that had a significant association with renal lithiasis risk. A greater knowledge of the paracellular pathway controlled by claudins and its regulation will allow us to develop future new treatments for idiopathic hypercalciuria and renal lithiasis. [ABSTRACT FROM AUTHOR]

Introduction: Kidney stone is a major public health problem. Over 5% of the population is affected by kidney stones, with causes a lifetime risk of transmitting renal lithiasis of about 8 to 10%.

Urinary lithiasis represents an important pathology in medical practice and requires a multidisciplinary approach. Its incidence is 10% and affects a large age group, with factors that can influence its increase in certain places. Its diagnosis appears as a finding in routine health checks or through renal colic syndrome, a characteristic condition and frequent consultation in the emergency services. Computed tomography for the study of renal lithiasis can provide more detailed information. It has a sensitivity, specificity and safety much greater than simple radiography of the abdomen and of excretory urography. Direct findings include calculus in the ureter, ureteral dilation above the calculus, halo sign with soft tissue density surrounding the calculus, and indirect findings include dilatation of the collecting and ureter system, increased kidney volume, and peri nephritic edema. [ABSTRACT FROM AUTHOR]

Background: Percutaneous nephrolithotomy (PNL) is the minimally invasive treatment elected for large kidney calculi (>2cm), staghorn calculi, inferior calyceal lithiasis, hard consistency calculi (calcium oxalate monohydrate or cystine) and lithiasis at the level of a malformed kidney. The aim was to analyse the results, which were obtained in the clinic for one year from the implementation of the method in patients with urolithiasis treated by PNL. Material and methods: The transversal descriptive study was performed in the group of 43 patients with urolithiasis, subjected to PNL treatment, throughout 2019. Results: The mean age of kidney stone patients treated by PNL was 55±7 years, among them 29 (67.5%) women and 14 (32.5%) men. The anatomical distribution of nephrolithiasis was: right kidney – 21(48.9%) patients, left kidney –22 (51.1%) patients. The post-operative period in most cases was 5 days. Most of the operated calculi had the following dimensions: 2-2.5 cm in 18 (41.86%) patients, 2.6-4 cm in 16 (37.2%) patients and over 4.5 cm in 9 (20.93%) patients. Postoperative complications were detected and distributed according to Clavien-Dindo scale (CDS). The majority of detected complications were minor (CDS grade 1) in 31 (72%) patients, CDS 2 in 7 (14%) patients and CDS 3b in 6 (14%) patients. Patients with CDS complications grade 4 and 5 were not detected. In 3 (7%) patients the procedure was of “tube-less” type and in 1 (2.3%) patient with double-pointed canal. Conclusions: The success of PNL intervention depends on multiple factors, such as calculus composition, dimension and location in the urinary tract, the patient’s body mass index, as well as collecting system anatomy. PNL is a safe and effective procedure with a 90-100% stone-free rate and minor complications.

Background and objective: Nephrolithiasis (NL) is a public health problem in the population of Southeast Mexico because of its high prevalence and recurrence. The evolution of this pathology can result in renal damage and may even cause chronic kidney disease (CKD), leading to a reduced glomerular filtration rate (GFR), decreased kidney function, and kidney loss in advanced stages. However, few studies support this evidence in the population. The present study aimed to determine risk factors associated with CKD in adult patients in an endemic population of Mexico. Materials and methods: A case-control study was carried out with patients diagnosed with NL. Additionally, the clinical information of patients (age, weight, height, blood pressure, comorbidities, and time of progress of NL), characteristics of the stones (number, location, and Hounsfield units), and biochemical parameters were collected. Results: The recurrence of NL was associated with CKD (OR 1.91; 95% CI 1.37–2.27; p = 0.003). In addition, male sex (p = 0.016), surgical history (p = 0.011), bilateral kidney stones (p < 0.001), and urinary tract infections (p = 0.004) were other factors associated with CKD. Interestingly, thirty-two patients younger than 50 years old with >2 surgical events presented a significant decrease in GFR (p < 0.001). Conclusions: The recurrence of NL and the number of surgical events were risk factors associated with CKD in patients with NL treated in our population. [ABSTRACT FROM AUTHOR]

Background and objectives: Renal stones are widespread, with a lifetime prevalence of 10% in adults. Flexible ureteroscopy enables urologists to treat lower calyx stones or even complex renal stones through the natural orifice and achieve an acceptable stone-free rate. Hence, we analyzed the effectiveness and safety of FURS versus PCNL in treating renal stones between 20 and 40 mm in diameter. Materials and methods: We retrospectively analyzed 250 consecutive patients with large renal solitary stones (stone burden between 2 and 4 cm) from 1 January 2019 to 31 December 2020. The patients were divided into two groups: group 1 (125 patients), in which the patients were treated by a retrograde flexible ureteroscopic approach, and group 2 (125 patients), in which we used percutaneous nephrolithotomy. Stone characteristics and anatomical data were observed based on the computed tomography (CT) and/or KUB (Kidney-ureter-Bladder) radiography imaging archive. Results: The mean stone burden was 26.38 ± 4.453 mm in group 1 and 29.44 ± 4.817 mm in group 2. The stone-free rate after the first ureteroscopy was higher for the PNL(percutaneous nephrolithotomy) group (90.4%) than the F-URS group (68%). After two sessions of ureteroscopy, the SFR was 88.8% in the first group, and after three procedures, the SFR rose to 95.2%. The overall complication rate was higher in group 1 than in group 2 (18.4% vs. 16.8%), but without statistical relevance (p > 0.5). Furthermore, we encountered more grade III and IV complications in the PNL group (8.8% vs. 4.8%, p < 0.05). Conclusion: Flexible ureteroscopy proves to be efficient in treating renal stones over 2 cm. However, the patients must be informed that more than one procedure might be necessary to overcome the entire stone burden.

The elderly group is one of the most heterogeneous and vulnerable groups of the population in developed countries with a greater risk of suffering from imbalances, deficiencies and nutritional problems. Diet and nutritional status have a great influence particularly on the prevention or treatment of various diseases that affect these groups. Long-term accumulation of waste in the body and age-related changes in metabolism create many problems that shorten their life expectancy. Their diet and gastrointestinal function play a key role in their Urine composition. It seems that the gastrointestinal microbiome has a great influence on the metabolization and absorption of the ingredients of the diet. In this clinical trial, the authors concluded that oral administration of gum arabic dissolved in orange juice could conceivably wash out the renal stones and eliminate renal cysts which in the long-term did not raise any safety concerns. The oral administration of gum arabic reduces kidney failure and slows its progression, which might be ascribed to their antioxidant and free radical-scavenging properties. Gum arabic could be considered as an important natural medicinal compound, actually a fascinating one because of its high therapeutic capabilities. Therefore, a prospective observational study has been designed and aimed to assess the efficacy and safety of treatment with gum arabic in patients with nephrolithiasis and renal cysts. [ABSTRACT FROM AUTHOR]

Purpose: To compare percutaneous nephrolithotomy (PCNL) operations between patients with a preoperative nephrostomy tube and patients that the renal access was obtained at the time of the surgery. Materials and Methods: We retrospectively evaluated PCNL cases. Patients were divided into two groups. Group 1 – a non-nephrostomy tube (percutaneous nephrostomy, PCN) group and Group 2 – patients with a PCN placed before the procedure. All preoperatively placed PCN's were performed in emergency situations by interventional radiologists (IR). Complications were classified according to the Clavien-Dindo classification. We compared stone characteristics, operation time, complications, efficacy and PCN usability at surgery. Results: Five hundred twenty-seven patients who were submitted to PCNL for renal stones were included in the study. In 73 patients (13.9%) the PCNs were placed before the surgery. Patients and stone characteristics, mean operative time (p=0.830), complications (p=0.859) and stone-free rates (93.0%) were similar between the groups. There was a trend toward higher complication rates in Group 1, but the difference was not statistically significant. Only 21 (29.0%) of preoperatively placed PCNs were used during PCNL for establishing a tract. The reasons for not using PCN tract were: pelvic or infundibular insertion (30.0%) and suboptimal anatomic location (70.0%). Conclusions: Preoperative emergency inserted PCNs by IR usage rates were low during PCNL. Its placement neither affects the incidence of complications nor affects the operation time and outcomes. As such, when emergency renal drainage is indicated, the need for a future definitive PCNL should not influence the decision about the modality of renal drainage.

Abstract Background The diagnosis and follow-up of stone forming patients is usually performed by analysis of 24-h urine samples. However, crystallization risk varies throughout the day, being higher at night. The main objective of this study is to evaluate the urinary crystallization risk in adults and children by calculating risk indexes based on different collection periods. Methods The study included 149 adults (82 healthy and 67 stone-formers) and 108 children (87 healthy and 21 stone-formers). 24-h urine was collected, divided into 12-h daytime sample (8 am to 8 pm), and 12-h overnight sample (8 pm to 8 am next morning). Solute concentrations, the calcium to citrate ratio (Ca/Cit), and the ion activity product of calcium oxalate (AP[CaOx]) and calcium phosphate (AP[CaP]) were calculated in each 12-h sample and in overall 24-h urine. Assessments were also related to stone type. Results Ca/Cit and AP(CaOx) were significantly higher in stone forming patients than in healthy subjects. The 12-h overnight samples had the highest values for both risk indexes, confirming a greater risk for crystallization at night. The AP(CaP) index was significantly higher in patients with pure hydroxyapatite stones than healthy controls, but was not significantly different between stone-formers overall and healthy controls. Conclusions The calculation of risk indexes is a simple method that clinicians can use to estimate crystallization risk. For this purpose, the use of 12-h overnight urine may be a reliable alternative to 24-h collections.

Introduction: The idiopathic hypercalciuria is a frequent and not very recognized metabolic disorder which clinical course depends in great extent on changes in the dietary habits from the childhood. Objective: To characterize children and adolescents with idiopathic hypercalciuria according to the clinical, epidemiological and therapeutic variables. Methods: An observational, longitudinal and prospective investigation was carried out in 44 patients with idiopathic hypercalciuria, assisted in the Miscellaneous Service of Antonio María Béguez Cesar Southern Teaching Children Hospital in Santiago de Cuba, from January, 2014 to December, 2015. Results: The symptomatic forms of the disease were the most frequent (68.2 %); also, the male sex prevailed (72.7 %) and the average age was 7.2 ± 4 years. Statistical association existed among the preschool and school ages as for the diagnosis of idiopathic hypercalciuria. The recurrent macroscopic hematuria was the most usual symptom in the majority of cases (59.1 %); as long as, the 25.0 % of patients presented renal lithiasis and the diet and liquids-based non pharmacological treatment was associated with a satisfactory evolution in 68.2 % of the affected patients, although the remaining 31.8 % needed drugs treatment. Conclusions: The clinical and epidemiological characteristics of patients with idiopathic hypercalciuria of this case material didn't differ from the ones registered worldwide, taking into account that this metabolic disorder is relatively frequent in pediatric services. [ABSTRACT FROM AUTHOR]

Background and objective: Nephrolithiasis (NL) is a public health problem in the population of Southeast Mexico because of its high prevalence and recurrence. The evolution of this pathology can result in renal damage and may even cause chronic kidney disease (CKD), leading to a reduced glomerular filtration rate (GFR), decreased kidney function, and kidney loss in advanced stages. However, few studies support this evidence in the population. The present study aimed to determine risk factors associated with CKD in adult patients in an endemic population of Mexico. Materials and methods: A case-control study was carried out with patients diagnosed with NL. Additionally, the clinical information of patients (age, weight, height, blood pressure, comorbidities, and time of progress of NL), characteristics of the stones (number, location, and Hounsfield units), and biochemical parameters were collected. Results: The recurrence of NL was associated with CKD (OR 1.91; 95% CI 1.37–2.27; p = 0.003). In addition, male sex (p = 0.016), surgical history (p = 0.011), bilateral kidney stones (p < 0.001), and urinary tract infections (p = 0.004) were other factors associated with CKD. Interestingly, thirty-two patients younger than 50 years old with >2 surgical events presented a significant decrease in GFR (p < 0.001). Conclusions: The recurrence of NL and the number of surgical events were risk factors associated with CKD in patients with NL treated in our population.

The renal lithiasis is a frequent disease that affect between 4-15% of worldwide population with a high percentage of recurrences. The composition of the stone is variated, but, more than 80% of uroliths are of calcium oxalate. The mechanisms involved in the formation of calcific stones are not fully understood and the available treatment not permit the prevention and destruction of the stones at same time. For these reasons, many studies have been focused to understand the mechanism involved in the renal lithiasis and in the development the new drugs for the treatment and prevention of this pathology and its recurrences. In this paper, it is shown a review about formation of calcific stones, their treatment and the effectiveness of the herbal medicine as alternative treatment. Also, a list of antilithiatic remedies of cuban herbal medicine is showed.

The renal lithiasis is a frequent disease that affect between 4-15% of worldwide population with a high percentage of recurrences. The composition of the stone is variated, but, more than 80% of uroliths are of calcium oxalate. The mechanisms involved in the formation of calcific stones are not fully understood and the available treatment not permit the prevention and destruction of the stones at same time. For these reasons, many studies have been focused to understand the mechanism involved in the renal lithiasis and in the development the new drugs for the treatment and prevention of this pathology and its recurrences. In this paper, it is shown a review about formation of calcific stones, their treatment and the effectiveness of the herbal medicine as alternative treatment. Also, a list of antilithiatic remedies of cuban herbal medicine is showed. [ABSTRACT FROM AUTHOR]

Introduction and Objectives. The most common fusion anomaly of the kidney with an incidence of approximately 1 in every 500 births is represented by the horseshoe kidney (HSK). The most common complication of HSK is kidney lithiasis. Uretero-pelvic junction obstruction (UPJO) occurs in 1 in every 1500 births, and the three conditions can be associated. The purpose of this case report is to present the 3D laparoscopic pyeloplasty as treatment for uretero-pelvic junction obstruction in horseshoe kidney and multiple renal calculi. Materials and Methods. We present the case of a 33 years old male patient, with surgical history of percutaneous nephrolithotomy 7 years prior and two ESWL procedures 1 year before, admitted for recurrent right lumbar pain. The CT scan revealed HSK with dilated right pelvi-calyceal system suggesting right UPJO and multiple secondary renal calculi. We opted for a 3D laparoscopic transperitoneal pyeloplasty and calculi extraction. The surgery was performed in a standard flank position using three ports (a 12 mm for the camera and two working trocars of 10 mm and 5 mm). After a difficult dissection due to postoperative fibrosis and vascular anomalies, the renal pelvis was suspended with a suture wire from the abdominal wall to avoid the need of an additional trocar. Then the pelvis was incised and 11 stones were removed under direct vision. We proceeded to perform a standard dismembered Anderson-Hynes pyeloplasty. A 6 Fr ureteric double-J stent was inserted in an antegrade fashion over a guidewire. The pelvi-ureteric anastomosis was performed with continuous 4-0 Vicryl suture. Results. The operative time was 90 minutes. There were no intraoperative complications or incidents encountered. The patient was discharged on the 4th postoperative day. The JJ stent was removed after 21 days. Conclusions. Although it is a high-complexity surgery due to the aberrant vessels, renal isthmus, modified anatomy of the kidney and secondary lithiasis, the 3D laparoscopic pyeloplasty could be an effective and safe procedure for treating UPJO in horseshoe kidney and secondary multiple renal calculi, even in patients with previous renal surgeries. The 3D vision system reduces the operative time as it ensures better depth perception and faster and more precise surgical gestures. In the cases of recurrent renal lithiasis UPJO should be considered and immediately managed in order to achieve long term healing. [ABSTRACT FROM AUTHOR]

Background: Acute lymphoblastic leukemia (ALL) is a common malignant pathology, accounting for approximately 25% of pediatric cancers. The prognosis is favorable, with over 90% of cases being curable with treatment. Objective: The purpose of this report is to showcase the less common complications of chemotherapy treatment in a pediatric patient with ALL. Material and methods: A 12-year-old patient is admitted to the Pediatric Clinic, guided by the Emergency Medical Service for additional investigations, presenting with thigh pain and fever. Laboratory analyses reveal pancytopenia, with 41% lymphoblasts observed on peripheral blood smear, and bone marrow examination presenting the appearance of acute lymphoblastic leukemia with hematopoietic dislocation, pre-B cell immunophenotypic profile, and aberrant expression of myeloid marker (CD 13). Based on these investigations, a diagnosis of pre-B acute lymphoblastic leukemia with myeloid markers is established, and treatment is initiated according to the ALL IC-BFM 2009 Protocol. Approximately three and a half months after starting treatment, the patient's condition deteriorates, complaining of pain in the right abdominal flank accompanied by nausea and repeated vomiting unresponsive to analgesic, antiemetic, and antispasmodic treatment. Abdominal ultrasound and surgical consultation are performed, resulting in a diagnosis of right renal colic, right renal lithiasis, secondary grade II hydronephrosis of the right kidney, and acute cystitis. Results: Two days after consultation and treatment, the patient passes two calculi approximately 3-4 mm in size, with a high content of uric acid. Abdominal colic subsides, and microscopic hematuria appears. After four months of chemotherapy treatment, a bone marrow examination is repeated, revealing a normocellular, variably cellular bone marrow with all marrow series present. Conclusions: ALL is a frequently encountered malignant pathology in children, which, with appropriate treatment, carries a good prognosis but can be associated with complications. [ABSTRACT FROM AUTHOR]

Introduction: The rate of adverse renal events has been shown to be higher in patients treated with lesinurad plus a xanthine-oxidase inhibitor (XOI) than in patients treated only with a XOI. We reassessed the risks for various adverse renal events from a different perspective and devised a hypothesis to explain the results.Methods: We used data from phase 3 trials that were publicly available from the full prescribing information document and estimated the relative risk and the number needed to treat for increased serum creatinine (sCri), renal failure, and renal lithiasis. We examined these risks for each treatment group and the risks stratified by estimated glomerular filtration rate (eGFR).Results: Overall, the relative risk for sCri was > 1.0 with the 400 mg/day dose of lesinurad and higher with the 200 mg/day dose, but it was < 1.0 for both lithiasis and renal failure with the 200 mg/day dose. The relative risk was only statistically significant for sCri with the highest dose of lesinurad. When results stratified by eGFR were considered, the rates of adverse events increased with declining renal function, but the relative risks decreased in parallel, as the rate of adverse events increased much more in the placebo arm than in the active arm (200 mg/day dose). Indeed, the relative risk was only significant for the highest dose of lesinurad in patients with normal eGFR.Conclusion: The rate of sCri events was higher in patients treated with both lesinurad and a XOI rather than a XOI alone. This rate was found to increase with decreasing eGFR, but as it does in for both active and placebo arms the relative risk is not different from that observed in the placebo arms in the labeled 200 mg/day dose. This may be explained by pathophysiological changes that develop in chronic kidney disease. [ABSTRACT FROM AUTHOR]

The fused crossed renal ectopia presents an incidence of 1:1000 live births. It is more frequent in men with a ratio of 2:1 and left-right ectopia is the most frequent and is associated with lithiasis formation in 9%, the diagnosis is made by conventional imaging studies and the treatment is aimed at complications more than the anatomical alteration itself. We present the case of a 44-years-old male patient who began with abdominal pain in the right renal fossa, associated with recurrent urinary tract infections, requesting a CT scan documenting crossed renal ectopia and pyelic lithiasis. We decided to perform endourological treatment, performing percutaneous nephrolithotomy guided by ultrasound, fragmenting all the lithiasic load, remaining free of stones. [ABSTRACT FROM AUTHOR]

Purpose: To compare percutaneous nephrolithotomy (PCNL) operations between patients with a preoperative nephrostomy tube and patients that the renal access was obtained at the time of the surgery. Materials and Methods: We retrospectively evaluated PCNL cases. Patients were divided into two groups. Group 1 - a non-nephrostomy tube (percutaneous nephrostomy, PCN) group and Group 2 - patients with a PCN placed before the procedure. All preoperatively placed PCN's were performed in emergency situations by interventional radiologists (IR). Complications were classified according to the Clavien-Dindo classification. We compared stone characteristics, operation time, complications, efficacy and PCN usability at surgery. Results: Five hundred twenty-seven patients who were submitted to PCNL for renal stones were included in the study. In 73 patients (13.9%) the PCNs were placed before the surgery. Patients and stone characteristics, mean operative time (p=0.830), complications (p=0.859) and stone-free rates (93.0%) were similar between the groups. There was a trend toward higher complication rates in Group 1, but the difference was not statistically significant. Only 21 (29.0%) of preoperatively placed PCNs were used during PCNL for establishing a tract. The reasons for not using PCN tract were: pelvic or infundibular insertion (30.0%) and suboptimal anatomic location (70.0%). Conclusions: Preoperative emergency inserted PCNs by IR usage rates were low during PCNL. Its placement neither affects the incidence of complications nor affects the operation time and outcomes. As such, when emergency renal drainage is indicated, the need for a future definitive PCNL should not influence the decision about the modality of renal drainage. [ABSTRACT FROM AUTHOR]

Background: We analyzed the effect of comprehensive care on the patients who received minimally invasive percutaneous nephrolithotomy (MPCNL). Methods: Patients hospitalized from 2013-2014 in Zhumadian Central Hospital (n=124) were enrolled and divided into two groups on random basis. The control group was treated with routine nursing model while the observation group was given comprehensive care additionally. The surgery time, degree of comfort, complications and successful cases, hospitalization time, sleep quality, nursing satisfaction and changes of systolic pressure, pulse and respiratory at different time were observed and analyzed. Results: The surgery time of the control group was significantly longer than that of observation group (P

Con el objetivo de evaluar la eficacia y seguridad de la terapia con Renalof en pacientes portadores de urolitiasis cálcica, para la desaparición y/o disminución de litiasis cálcica, se realizó un ensayo clínico controlado, aleatorizado fase III, en 2 grupos en paralelos a doble ciegas con placebo. Se eligieron pacientes de 18 a 65 años de edad, portadores de litiasis menor de 10 mm, a los cuales se les indicó un esquema de tratamiento con un producto natural producido por laboratorio español Catálisis SA, en dosis de 1 cápsula 3 veces al día durante 3 meses, con un seguimiento clínico-radiológico, tomográfico y ecográfico mensuales, que registraron los efectos adversos. Como criterio principal de evaluación se tomó el tamaño y número del cálculo con respuesta favorable cuando el tamaño del cálculo disminuyó o desapareció. Se aleatorizaron a 110 pacientes para recibir Renalof (n=52) y placebo (n=58). La disminución de los cálculos fueron de 7,7 %, para el grupo con Renalof y de 0 % en el placebo al tercer mes, mientras que la desaparición de los cálculos fue del 86,5 % de respuesta al tercer mes con Renalof. La media del número de cólicos disminuyó a los 3 meses, solo el 0,4 ± 1,3 para el grupo de Renalof. Se concluye que el Renalof es un producto eficiente en la destrucción o disminución de los cálculos cálcicos renoureterales, sin efectos adversos.A double-blind, randomized, placebo-controlled, parallel group phase III clinical trial was conducted with the purpose of evaluating the effectiveness and safety of Renalof to remove and/or reduce calcium lithiasis in patients with calcium urolithiasis. The patients chosen were aged 18-65 and had stones smaller than 10 mm. These patients were treated with a natural product manufactured by the Spanish laboratory Catálisis SA, in a dosage of 1 capsule 3 times a day during 3 months, and monthly clinical, radiological, tomographic and echographic follow-up to record adverse effects. The main evaluation criterion was the size and number of the calculi, with favorable response when they either disappeared or their size was reduced. 110 patients were randomized to Renalof (n=52) and placebo (n=58). Stone size reduction was 7.7 % for the Renalof group and 0 % for the placebo group by the third month, whereas the stone disappearance response was 86.5 % by the third month for the Renalof group. The mean number of colics decreased by the third month, with only 0.4 ± 1.3 for the Renalof group. It was concluded that Renalof is an efficient product for the destruction or reduction of calcium renoureteral calculi, with no adverse effects.

Objective To evaluate the outcomes of conservatively managed staghorn calculi, specifically looking at morbidity and mortality, incidence of infections and progressive changes in renal function. Patients and Methods A total of 22 patients with unilateral or bilateral staghorn calculi, who were treated conservatively, were included in the study. Patients were reviewed yearly with symptom assessment, urine culture and measurement of estimated glomerular filtration rate. Results The presentations to the urology department of staghorn calculi were incidental (41%), haematuria (36%), abdominal discomfort (5%) and recurrent urinary tract infections ( UTIs; 18%). The reasons for conservative management in the cohort were comorbidities (59%), patient choice (36%) or poor access/anatomy (5%). In the whole cohort the rate of recurrent UTIs was 50%, the progressive renal failure rate was 14%, the disease-specific mortality rate was 9%, the dialysis dependence rate was 9% and the rate of hospital attendances attributable to stone-related morbidity was 27%. Comparison of outcome measures between the unilateral and bilateral staghorn stones showed statistically significant differences in disease-specific mortality (0 vs 40%) and morbidity (12 vs 80%) in favour of the unilateral group. Although there was a lower incidence of UTIs (41 vs 80%), renal deterioration (6 vs 40%) and dialysis requirement (6 vs 20%) in the unilateral group, these findings were not statistically significant. Conclusions From the results, we conclude that conservative management of staghorn calculi is not as unsafe as previously thought. Careful patient selection to include unilateral asymptomatic stones with minimal infection, and thorough counselling with regard to the risks, could make conservative management a suitable option for specific patient groups. [ABSTRACT FROM AUTHOR]

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