141 results on '"Renal neoplasia"'
Search Results
2. Emerging entities of renal cell neoplasia
- Author
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Brett Delahunt, John N. Eble, Lars Egevad, John Yaxley, Michelle Thunders, and Hemamali Samaratunga
- Subjects
Renal neoplasia ,Renal cell carcinoma ,Classification ,International Society of Urological Pathology ,World Health Organization ,Surgery ,RD1-811 ,Pathology ,RB1-214 - Abstract
Abstract The current classification of renal cell carcinoma (RCC) was formulated at the meeting of the World Health Organization Renal Tumor Panel in 2015, with the results published in the fourth edition of the World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs Bluebook in 2016. At that meeting a number of tumor types were designated as emerging or provisional entities as it was felt that they were insufficiently characterized to merit inclusion as a recognized type of RCC. One tumor type included in this designation was thyroid-like follicular RCC. Since the publication of the 2016 classification this tumor type has been further characterized and in addition to this, detailed studies on three other types of RCC (multifocal oncocytoma-like tumors associated with oncocytosis, eosinophilic solid and cystic RCC and biphasic squamoid alveolar RCC) have been published. It is now apparent that these four tumors are unique morphotypes and genotypes of RCC, and are likely to be included in the next edition of the World Health Organization classification of renal tumors. Multifocal oncocytoma-like tumors associated with oncocytosis is a benign process characterized by the presence of hundreds to thousands of oncocytic tumors in a single kidney. These tumors occur sporadically and are unrelated to the tumors of Birt-Hogg-Dubé syndrome. Eosinophilic solid and cystic RCC is characterized by a solid and cystic architecture with tumor cells consisting of bulky eosinophilic and granular cytoplasm with intracytoplasmic vacuolation. Thyroid-like follicular RCC occurs in younger patients with a female predominance. The tumor bears a striking resemblance to follicular carcinoma of the thyroid with follicles containing intraluminal proteineacous material resembling thyroglobulin. Immunostains for thyroid markers are negative. Finally, biphasic squamoid alveolar RCC consists of aggregates of large cells with pale eosinophilic cytoplasm usually arranged in a glomeruloid/alveolar pattern and surrounded by a border of basophilic cells with scanty cytoplasm. The genotype of the tumor, as well its recorded association with typical papillary RCC, has led to the suggestion that it is related to type 1 papillary RCC.
- Published
- 2019
- Full Text
- View/download PDF
3. Advancing the diagnosis and classification of renal cell carcinomas
- Author
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Joseph A. Rothwell
- Subjects
Renal neoplasia ,Proteomics ,Total protein approach ,Renal cancer diagnosis ,Medicine - Abstract
Abstract
- Published
- 2021
- Full Text
- View/download PDF
4. Metastatic renal interstitial cell tumor in a dog.
- Author
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Rissi, Daniel R. and Dill-Okubo, Jennifer A.
- Subjects
INTERSTITIAL cells ,LYMPHATIC metastasis ,CELL tumors ,LABRADOR retriever ,CYCLOOXYGENASE 2 ,HISTOCHEMISTRY ,MITOSIS - Abstract
Renal interstitial cell tumor (RICT) is a rare renal sarcoma of dogs that arises from renal interstitial cells. Herein we describe a RICT in an 8-y-old female Labrador Retriever dog that died after a 2-d history of lethargy and disorientation. Grossly, soft white nodules of 1–10 mm diameter were present in the renal cortex and corticomedullary junction of both kidneys, left cardiac ventricular wall, and right cerebral hemisphere. A pale-white to yellow, firm, irregular mass effaced 80% of the right pulmonary parenchyma, involving mainly the cranial and middle lobes, and the adjacent tracheobronchial lymph nodes. Histologically, the renal, myocardial, and cerebral neoplasm consisted of interlacing bundles of stellate-to-spindle cells with eosinophilic vacuolated cytoplasm and round-to-oval nuclei with finely stippled chromatin. The mitotic count was 28 per 2.37 mm
2 . Alcian blue stain revealed an extracellular myxomatous matrix throughout the neoplasm. Neoplastic cells had cytoplasmic immunolabeling for vimentin and cyclooxygenase 2. The pulmonary and tracheobronchial neoplasm consisted of infiltrative nodules of cuboidal epithelial cells that had a moderate amount of eosinophilic cytoplasm and round nuclei with coarsely stippled chromatin. There were 5 mitoses per 2.37 mm2 . Neoplastic cells had cytoplasmic and nuclear immunolabeling for cytokeratin AE1/AE3 and thyroid transcription factor 1, respectively. Morphologic and immunohistochemical findings were consistent with a RICT with cardiac and cerebral metastases, and a pulmonary carcinoma with tracheobronchial lymph node metastasis. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
5. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results
- Author
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Roberta Troia, Chiara Agnoli, Federico Fracassi, Giuliano Bettini, Alessandra Sfacteria, Luciano Pisoni, and Francesco Dondi
- Subjects
Erythropoietin ,Feline ,Immunohistochemistry ,Manual erythrocytapheresis ,Renal neoplasia ,Zoology ,QL1-991 - Abstract
This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-year-old cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat’s clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells.
- Published
- 2017
6. Labial metastasis of renal neoplasia - A diagnostic challenge.
- Author
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Gatti, Arthur Paredes, Leal Oliva, Ramon Nobre, Nardi, Caroline Nicolau, Yoshino Bonifaci, Ana Maria, Tangoda, Lilian Kanawa, and Ramos Takahashi, Lívia Akemi
- Abstract
• Lip metastasis of Renal Neoplasia is a very unusual oncological manifestation and difficult to differentiate. • That's the first case related on Brazil, the second described in the literature. • This case contributes to the knowledge of the manifestations of neoplastic dissemination and cell differentiation. Cutaneous spread of solid visceral metastasis is very unusual presentation, usually in breast, lung, colon, ovarian carcinomas, and malignant melanoma. Less than 5% of cases of cutaneous spread are from renal neoplasms. We present the case of a 48-year-old woman with a large lower lip tumor whose anatomopathological analysis of the lesion led us to identify a Clear Cell Renal Cell Carcinoma (ccRCC). The clinical manifestations of the ccRCC can be mild, generating a late diagnosis through metastasis of primary neoplasia. Their presentations can be varied, as described in this report. The knowledge of the different types of presentation of CCCR metastases can assist in decision making, but the progression of staging often only allows palliative measures. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
7. Assessment of tumour‐associated necrosis provides prognostic information additional to World Health Organization/International Society of Urological Pathology grading for clear cell renal cell carcinoma.
- Author
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Dagher, Julien, Delahunt, Brett, Rioux‐Leclercq, Nathalie, Egevad, Lars, Coughlin, Geoff, Dunglison, Nigel, Gianduzzo, Troy, Kua, Boon, Malone, Greg, Martin, Ben, Preston, John, Pokorny, Morgan, Wood, Simon, and Samaratunga, Hemamali
- Subjects
- *
RENAL cell carcinoma , *TUMOR necrosis factors , *METASTASIS , *IMMUNOHISTOCHEMISTRY , *APOPTOSIS - Abstract
Aims: The aims of this study were to evaluate the impact of tumour‐associated necrosis (TAN) on metastasis‐free survival for clear cell renal cell carcinoma (RCC), and to determine whether TAN provides survival information additional to World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading. Methods and results: The study consisted of 376 cases of clear cell RCC treated by nephrectomy, for which follow‐up was available. WHO/ISUP grade was assigned, and sections were assessed for the presence of TAN. American Joint Committee on Cancer (AJCC) pT staging category and tumour size were also recorded. The development of metastatic disease was taken as the clinical endpoint, and survival analyses, utilising univariate and multivariate models, were performed. WHO/ISUP grades were: grade 1, 35 cases (9.3%); grade 2, 188 cases (50.0%); grade 3, 91 cases (24.2%); and grade 4, 62 cases (16.5%). Staging categories were pT1–pT2 [234 tumours (62.2%)] and pT3–pT4 [139 tumours (37.0%)]. TAN was seen in 128 cases (34.0%). Neither TAN nor metastases were seen in grade 1 tumours. Among grade 2–4 tumours, those with TAN had a significantly worse prognosis than those without TAN (P = 0.017, P = 0.04, and P = 0.006, respectively). Multivariate analysis (WHO/ISUP grade, pT staging category, and TAN) showed all three variables to be independently associated with outcome (P = 0.009, P = 0.005, and P = 0.001, respectively). For all tumour grades and pT staging categories, it was found that the presence of TAN was associated with a 2.91‐fold greater risk of metastatic disease. Conclusion: Tumour‐associated necrosis is an important prognostic factor for clear cell RCC, independently of WHO/ISUP grade. This supports the suggestion that TAN could be incorporated into tumour grading criteria. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
8. Grading of renal cell carcinoma.
- Author
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Delahunt, Brett, Eble, John N, Egevad, Lars, and Samaratunga, Hemamali
- Subjects
- *
RENAL cell carcinoma , *CANCER chemotherapy , *SQUAMOUS cell carcinoma , *RADIOTHERAPY , *METASTASIS - Abstract
Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon nucleolar prominence/eosinophilia for grades 1–3, while grade 4 requires nuclear anaplasia (including tumour giant cells, sarcomatoid differentiation and/or rhabdoid morphology). The grading system was adopted formally by the International Society of Urological Pathology (ISUP) and subsequently by the World Health Organisation (WHO), being designated the WHO/ISUP grading classification in the fourth edition of the WHO classification tumours of the urinary system and male genital organs (2016). This grading system has been validated for both clear cell and papillary RCC. Validation studies for chromophobe RCC failed to demonstrate a correlation between grade and outcome for both the superseded Fuhrman grading system and the WHO/ISUP grading classification, and it has been recommended that these tumours not be graded. The WHO/ISUP system has been incorporated into the structured reports of the International Cancer Collaboration on Cancer Reporting for both clear cell and papillary RCC. It is also noted that other types of RCC may be graded, but it must be emphasised in the report that this is for descriptive and diagnostic purposes, and not outcome prediction. More recent studies have shown the incorporation of the presence of tumour necrosis into RCC grading to improve outcome prediction, and this has been validated in several studies. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
9. Proceedings of the 2018 National Toxicology Program Satellite Symposium.
- Author
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Elmore, Susan A., Carreira, Vinicius, Labriola, Caralyn S., Mahapatra, Debabrata, McKeag, Sean R., Rinke, Matthias, Shackelford, Cynthia, Singh, Bhanu, Talley, Ashley, Wallace, Shannon M., Wancket, Lyn M., and Willson, Cynthia J.
- Subjects
- *
ODONTOBLASTS , *AMELOBLASTS , *OLIGONUCLEOTIDES - Abstract
The 2018 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Indianapolis, Indiana, at the Society of Toxicologic Pathology's 37th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks along with select images that were used by the audience for voting and discussion. Various lesions and other topics covered during the symposium included seminiferous tubule dysgenesis in rats, ameloblast and odontoblast degeneration/necrosis in a Sprague Dawley rat, intestinal leiomyositis in a beagle dog, gallbladder mucinous hyperplasia, focus of hepatocellular alteration and bile duct alteration in otters, renal tubule cytoplasmic vacuolation with basophilic granules in mice treated swith antisense oligonucleotide therapy, a uterine choriocarcinoma in a rhesus macaque, and rete ovarii proliferative ovarian lesions in various aged rat strains. One particularly provocative lesion was a malignant neoplastic proliferation in the renal pelvic region of a cynomolgus macaque from a 21-day study. Additional challenging lesions included thyroid proliferative lesions in zebra fish and gross findings in fish larvae during routine chemical screening. The Rabbit and Minipig International Harmonization of Nomenclature and Diagnostic Criteria Organ Working Groups also presented a series of challenging lesions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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10. Primary leiomyosarcoma of kidney with metastasis to contralateral kidney. Case report.
- Author
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CIRIACO, SERGIO VASQUEZ, ESPINOZA, JAIME ARON GARCÍA, and PEDRO, ELENA ENSELMINI GARCIA
- Subjects
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LEIOMYOSARCOMA , *KIDNEY tumors , *METASTASIS , *NEPHRECTOMY ,CANCER histopathology - Abstract
Introduction: Renal leiomyosarcoma is a rare entity in the world and its understanding is based on reports and various cases; however, the prognosis is bleak for its malignant potential and an average survival of 18 months. Clinical case: A 54-year-old woman with a clinical picture of 6 months of pain in the right flank and a tomographic image of a bilateral renal lesion underwent right radical nephrectomy and left conservative surgery. The definitive histopathological study reported right primary renal leiomyosarcoma with left metastasis. Conclusion: Renal leiomyosarcoma is an entity of low incidence and high mortality; however, our case represents the minority of patients with contralateral kidney metastasis reported in the literature. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
11. Eosinophilic Solid and Cystic Renal Cell Carcinoma With Melanin Pigment—Expanding the Morphological Spectrum
- Author
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Ondřej Hes and Alessandro Pietro Aldera
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Renal neoplasia ,TFE3 ,Favorable prognosis ,urologic and male genital diseases ,Kidney tumor ,Translocation, Genetic ,Pathology and Forensic Medicine ,Young Adult ,Renal cell carcinoma ,Eosinophilic ,Biomarkers, Tumor ,Humans ,Medicine ,Carcinoma, Renal Cell ,In Situ Hybridization, Fluorescence ,Melanins ,business.industry ,medicine.disease ,Kidney Neoplasms ,Mutation ,Immunohistochemistry ,Surgery ,Anatomy ,business ,Melanin pigment - Abstract
Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is an emerging entity in renal neoplasia with distinctive histopathological findings and a generally favorable prognosis. The presence of melanin pigment in a renal tumor typically prompts the observer to consider the microphthalmia-associated transcription family translocation renal cell carcinomas. We present a renal tumor occurring in a 19-year-old male patient which had the typical morphology of ESC-RCC but showed the additional finding of focal melanin pigment. This tumor showed strong and diffuse positive immunolabeling with paired box gene 8 and cytokeratin 20, and was negative with epithelial membrane antigen, carbonic anhydrase 9, CD117, cytokeratin 7, and transcription factor E3. Human melanoma black-45 showed focal positivity, but Melan-A was negative. Next-generation sequencing revealed a mutation in the TSC2 gene (c.4490C > G, p.[Pro1497Arg] and c.1257 + 1del) and break apart fluorescence in-situ hybridization with TFE3 and TFEB probes was negative. In this case report, we present the novel finding of melanin pigment occurring in a genetically proven and otherwise typical ESC-RCC, and briefly discuss the differential diagnostic considerations.
- Published
- 2021
- Full Text
- View/download PDF
12. The ISUP system of staging, grading and classification of renal cell neoplasia
- Author
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Hemamali Samaratunga, Troy Gianduzzo, and Brett Delahunt
- Subjects
Classification ,Grading ,International Society of Urological Pathology, ISUP ,Kidney cancer ,Renal neoplasia ,Staging ,Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
There have been significant changes in the staging, classification and grading of renal cell neoplasia in recent times. Major changes have occurred in our understanding of extra-renal extension by renal cell cancer and how gross specimens must be handled to optimally display extra-renal spread. Since the 1981 World Health Organization (WHO) classification of renal tumors, in which only a handful of different entities were reported, many new morphological types have been described in the literature, resulting in 50 different entities reported in the 2004 WHO classification. Since 2004, further new entities have been recognized and reported necessitating an update of the renal tumor classification. There have also been numerous grading systems for renal cell carcinoma with Fuhrman grading, the most widely used system. In recent times, the prognostic value and the applicability of the Fuhrman grading system in practice has been shown to be, at best, suboptimal. To address these issues and to recommend reporting guidelines, the International Society of Urological Pathology (ISUP) undertook a review of adult renal neoplasia through an international consensus conference in Vancouver in 2012. The conduct of the conference was based upon evidence from the literature and the current practice amongst recognized experts in the field. Working groups selected to deal with key topics evaluated current data and identified points of controversy. A pre-meeting survey of the ISUP membership was followed by the consensus conference at which a formal ballot was taken on each key issue. A 65% majority vote was taken as consensus. This review summarizes the outcome and recommendations of this conference with regards to staging, classification and grading of renal cell neoplasia.
- Published
- 2014
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13. Neuroblastoma-associated Renal Cell Carcinoma: A Case Report and Review of the Literature
- Author
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Ananth Shankar, Manuel Rodriguez-Justo, Margaret Olabisi Ogunbiyi, and Trevor Gaunt
- Subjects
Male ,Adolescent ,Tumor suppressor gene ,Renal neoplasia ,urologic and male genital diseases ,Neuroblastoma ,Germline mutation ,Renal cell carcinoma ,Humans ,Medicine ,Carcinoma, Renal Cell ,neoplasms ,Germ-Line Mutation ,business.industry ,Cancer predisposition ,Advanced stage ,Neoplasms, Second Primary ,Hematology ,medicine.disease ,Kidney Neoplasms ,female genital diseases and pregnancy complications ,Oncology ,Pediatrics, Perinatology and Child Health ,Cancer research ,Second Malignancy ,Female ,business - Abstract
Neuroblastoma-associated renal cell carcinoma (RCC) is a very rare subtype of renal neoplasia and only a handful of cases have been reported. Here we present a 15-year-old boy with metastatic RCC with a previous history of advanced stage neuroblastoma and germline mutation in the TP53 tumor suppressor gene. The probability of the RCC and indeed, the neuroblastoma itself being related to a cancer predisposition syndrome rather than a therapy induced second malignancy, is discussed.
- Published
- 2021
- Full Text
- View/download PDF
14. Advancing the diagnosis and classification of renal cell carcinomas
- Author
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Rothwell, Joseph A.
- Published
- 2021
- Full Text
- View/download PDF
15. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results.
- Author
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Troia, Roberta, Agnoli, Chiara, Fracassi, Federico, Bettini, Giuliano, Sfacteria, Alessandra, Pisoni, Luciano, and Dondi, Francesco
- Subjects
- *
RENAL cancer , *POLYCYTHEMIA , *CAT diseases , *IMMUNOSTAINING , *POLYURIA - Abstract
This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-yearold cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat's clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
16. Fumarate Hydratase ( FH ) c.1431_1433dupAAA (p.Lys477dup) variant is not associated with FH protein deficiency and increased 2SC in two separate patients with renal neoplasia
- Author
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Sounak Gupta, Wei Shen, John C. Cheville, and Rafael E. Jimenez
- Subjects
Text mining ,business.industry ,Fumarase ,Genetics ,Cancer research ,Renal neoplasia ,Biology ,business ,Genetics (clinical) - Published
- 2021
- Full Text
- View/download PDF
17. VON HIPPEL–LINDAU SYNDROME
- Author
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Luke Maese, Benjamin L. Maughan, and Samantha Greenberg
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,medicine ,Renal neoplasia ,business ,Von Hippel-Lindau syndrome - Published
- 2020
- Full Text
- View/download PDF
18. Metastatic renal interstitial cell tumor in a dog
- Author
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Daniel R. Rissi and Jennifer A. Dill-Okubo
- Subjects
Pathology ,medicine.medical_specialty ,General Veterinary ,business.industry ,Carcinoma ,Renal neoplasia ,Sarcoma ,Renal interstitial cell ,medicine.disease ,Kidney Neoplasms ,Dogs ,Fatal Outcome ,Renal Sarcoma ,Animals ,Medicine ,Labrador Retriever ,Female ,Dog Diseases ,Brief Communications ,business ,Brain metastasis - Abstract
Renal interstitial cell tumor (RICT) is a rare renal sarcoma of dogs that arises from renal interstitial cells. Herein we describe a RICT in an 8-y-old female Labrador Retriever dog that died after a 2-d history of lethargy and disorientation. Grossly, soft white nodules of 1–10 mm diameter were present in the renal cortex and corticomedullary junction of both kidneys, left cardiac ventricular wall, and right cerebral hemisphere. A pale-white to yellow, firm, irregular mass effaced 80% of the right pulmonary parenchyma, involving mainly the cranial and middle lobes, and the adjacent tracheobronchial lymph nodes. Histologically, the renal, myocardial, and cerebral neoplasm consisted of interlacing bundles of stellate-to-spindle cells with eosinophilic vacuolated cytoplasm and round-to-oval nuclei with finely stippled chromatin. The mitotic count was 28 per 2.37 mm2. Alcian blue stain revealed an extracellular myxomatous matrix throughout the neoplasm. Neoplastic cells had cytoplasmic immunolabeling for vimentin and cyclooxygenase 2. The pulmonary and tracheobronchial neoplasm consisted of infiltrative nodules of cuboidal epithelial cells that had a moderate amount of eosinophilic cytoplasm and round nuclei with coarsely stippled chromatin. There were 5 mitoses per 2.37 mm2. Neoplastic cells had cytoplasmic and nuclear immunolabeling for cytokeratin AE1/AE3 and thyroid transcription factor 1, respectively. Morphologic and immunohistochemical findings were consistent with a RICT with cardiac and cerebral metastases, and a pulmonary carcinoma with tracheobronchial lymph node metastasis.
- Published
- 2020
- Full Text
- View/download PDF
19. Labial metastasis of renal neoplasia - A diagnostic challenge
- Author
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Ana Maria Yoshino Bonifaci, Caroline Nicolau Nardi, Arthur Paredes Gatti, Ramon Nobre Leal Oliva, Lilian Kanawa Tangoda, and Lívia Akemi Ramos Takahashi
- Subjects
Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Melanoma ,Renal neoplasia ,Case Report ,medicine.disease ,Metastasis ,Renal neoplasm ,Lesion ,03 medical and health sciences ,Clear cell renal cell carcinoma ,0302 clinical medicine ,medicine.anatomical_structure ,Labial tumor ,030220 oncology & carcinogenesis ,Medicine ,030211 gastroenterology & hepatology ,Surgery ,Presentation (obstetrics) ,medicine.symptom ,business - Abstract
Highlights • Lip metastasis of Renal Neoplasia is a very unusual oncological manifestation and difficult to differentiate. • That’s the first case related on Brazil, the second described in the literature. • This case contributes to the knowledge of the manifestations of neoplastic dissemination and cell differentiation., Introduction Cutaneous spread of solid visceral metastasis is very unusual presentation, usually in breast, lung, colon, ovarian carcinomas, and malignant melanoma. Less than 5% of cases of cutaneous spread are from renal neoplasms. Presentation of case We present the case of a 48-year-old woman with a large lower lip tumor whose anatomopathological analysis of the lesion led us to identify a Clear Cell Renal Cell Carcinoma (ccRCC). Discussion The clinical manifestations of the ccRCC can be mild, generating a late diagnosis through metastasis of primary neoplasia. Their presentations can be varied, as described in this report. Conclusion The knowledge of the different types of presentation of CCCR metastases can assist in decision making, but the progression of staging often only allows palliative measures.
- Published
- 2020
20. Neoplasias renales multiquísticas - Experiencia de 5 años
- Author
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Marisol Gramajo and Alina Fortuny
- Subjects
Pathology ,medicine.medical_specialty ,Renal cell carcinoma ,business.industry ,medicine ,Renal neoplasia ,General Earth and Planetary Sciences ,medicine.disease ,business ,Clear cell type ,General Environmental Science - Abstract
El Carcinoma de Células Renales (CCR) tipo células claras predominantemente quístico y la Neoplasia Renal Quística Multilocular de Bajo Potencial Maligno son entidades muy poco frecuentes y con excelente pronóstico. A continuación exponemos la experiencia de 5 años de dichas patologías en el Instituto Guatemalteco de Seguridad Social.
- Published
- 2020
- Full Text
- View/download PDF
21. Emerging entities of renal cell neoplasia
- Author
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John Yaxley, Hemamali Samaratunga, John N. Eble, Lars Egevad, Michelle Thunders, and Brett Delahunt
- Subjects
Pathology ,medicine.medical_specialty ,Urinary system ,medicine.medical_treatment ,Cell ,lcsh:Surgery ,urologic and male genital diseases ,World Health Organization ,Renal cell carcinoma ,Eosinophilic ,medicine ,lcsh:Pathology ,International Society of Urological Pathology ,business.industry ,Thyroid ,lcsh:RD1-811 ,medicine.disease ,Classification ,female genital diseases and pregnancy complications ,Basophilic ,medicine.anatomical_structure ,Renal neoplasia ,Thyroglobulin ,business ,Immunostaining ,lcsh:RB1-214 - Abstract
The current classification of renal cell carcinoma (RCC) was formulated at the meeting of the World Health Organization Renal Tumor Panel in 2015, with the results published in the fourth edition of the World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs Bluebook in 2016. At that meeting a number of tumor types were designated as emerging or provisional entities as it was felt that they were insufficiently characterized to merit inclusion as a recognized type of RCC. One tumor type included in this designation was thyroid-like follicular RCC. Since the publication of the 2016 classification this tumor type has been further characterized and in addition to this, detailed studies on three other types of RCC (multifocal oncocytoma-like tumors associated with oncocytosis, eosinophilic solid and cystic RCC and biphasic squamoid alveolar RCC) have been published. It is now apparent that these four tumors are unique morphotypes and genotypes of RCC, and are likely to be included in the next edition of the World Health Organization classification of renal tumors. Multifocal oncocytoma-like tumors associated with oncocytosis is a benign process characterized by the presence of hundreds to thousands of oncocytic tumors in a single kidney. These tumors occur sporadically and are unrelated to the tumors of Birt-Hogg-Dubé syndrome. Eosinophilic solid and cystic RCC is characterized by a solid and cystic architecture with tumor cells consisting of bulky eosinophilic and granular cytoplasm with intracytoplasmic vacuolation. Thyroid-like follicular RCC occurs in younger patients with a female predominance. The tumor bears a striking resemblance to follicular carcinoma of the thyroid with follicles containing intraluminal proteineacous material resembling thyroglobulin. Immunostains for thyroid markers are negative. Finally, biphasic squamoid alveolar RCC consists of aggregates of large cells with pale eosinophilic cytoplasm usually arranged in a glomeruloid/alveolar pattern and surrounded by a border of basophilic cells with scanty cytoplasm. The genotype of the tumor, as well its recorded association with typical papillary RCC, has led to the suggestion that it is related to type 1 papillary RCC.
- Published
- 2019
- Full Text
- View/download PDF
22. Características clinicoterapéuticas de niños y adolescentes con neoplasias renales.
- Author
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Fariñas, Amparo Mirabal, Yalcouye, Hamadou, Blanco, Manuel Pantoja, Landeau, Carlos Cobas, and Romero García, Lázaro Ibrahim
- Abstract
A descriptive and cross sectional study of 51 patients with renal neoplasia, assisted in the Urology Service of the Southern Teaching Pediatric Hospital in Santiago de Cuba was carried out from January, 1999 to December, 2013, in order to characterize them from the clinical and therapeutic points of view. Female sex, the age group 0 - 4 years, the tumoral abdominal mass as main clinical manifestation, the nephroblastoma as the most common histological type prevailed in the series, as well as the stage III of the disease. Patients were treated according to the oncoespecific Cuban protocol, with prevalence of surgery, together with the chemotherapy and the radiotherapy. The clinical course of those affected was good and the proportion of dead patients in early clinical stages was minimum. [ABSTRACT FROM AUTHOR]
- Published
- 2015
23. Bilateral Renal Tubular Neoplasm in a Channel-billed Toucan ( Ramphastos vitellinus).
- Author
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Mainez, Mireia, Cardona, Teresa, Such, Roger, Juan-Sallés, Carles, and Garner, Michael M.
- Subjects
- *
BIRD diseases , *RAMPHASTOS , *AVIAN medicine , *SOFT tissue tumors , *PULMONARY adenomatosis - Abstract
An adult male channel-billed toucan ( Ramphastos vitellinus) was presented with a history of weakness, dyspnea, and severe dilatation of the coelomic cavity, which was caused by accumulation of serohemorrhagic fluid. Radiographs revealed increased radiodensity and thickness of the descending aorta and a pectoral mass, and blood test results revealed anemia, hypocalcemia, hypoproteinemia, and hyperuricemia. On ultrasound examination, a hyperechoic enlarged soft tissue mass was found in the caudodorsal region of the coelom. The bird did not respond to supportive care and died. Postmortem examination revealed severe, bilateral nephromegaly due to multifocal to coalescing renal tubular adenomas (adenomatosis), which was complicated with renal gout and soft tissue mineralization. Relevant concurrent diseases included hepatic hemochromatosis, subcutaneous cestodiasis with cellulitis, and systemic amyloidosis. There are few documented cases of neoplasms in ramphastid birds and to our knowledge, this is the first report of a renal neoplasm in a channel-billed toucan. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
24. Renal Neoplasia in Hyperparathyroidism–Jaw Tumor Syndrome
- Author
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Sounak Gupta and Lori A. Erickson
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Adolescent ,business.industry ,Tumor Suppressor Proteins ,Renal neoplasia ,General Medicine ,Hyperparathyroidism, Primary ,Immunohistochemistry ,Kidney Neoplasms ,Hyperparathyroidism-Jaw Tumor Syndrome ,Mutation ,Humans ,Medicine ,business - Published
- 2021
- Full Text
- View/download PDF
25. Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia
- Author
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Rola Saleeb, Priya Rao, Reza Alaghehbandan, Fiona Maclean, Liang Cheng, Mahul B. Amin, Cristina Magi-Galluzzi, Isabela Werneck da Cunha, Qiu Rao, Michelle S. Hirsch, Ondrej Hes, Jennifer B. Gordetsky, Kiril Trpkov, Ying-Bei Chen, Maria S. Tretiakova, José I. López, Sounak Gupta, Santosh Menon, Rohit Mehra, Steven C. Smith, Peter A. Humphrey, Huiying He, Rajal B. Shah, Jesse K. McKenney, George J. Netto, Payal Kapur, Christopher G. Przybycin, Anthony J. Gill, Virginie Verkarre, Abbas Agaimy, Ming Zhou, Sean R. Williamson, Lawrence D. True, Victor E. Reuter, Adebowale J. Adeniran, Fumiyoshi Kojima, Pedram Argani, Jonathan I. Epstein, Eva Comperat, Satish K. Tickoo, John C. Cheville, and Sara E. Wobker
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Genitourinary system ,Renal neoplasia ,urologic and male genital diseases ,medicine.disease ,World health ,Kidney Neoplasms ,Pathology and Forensic Medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Renal cell carcinoma ,030220 oncology & carcinogenesis ,Eosinophilic ,medicine ,Anaplastic lymphoma kinase ,Humans ,Identification (biology) ,business ,Genetic testing - Abstract
The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in renal neoplasia, particularly focusing on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. In the era of evolving histo-molecular classification of renal neoplasia, morphology is still key. However, entities (or groups of entities) are increasingly characterized by specific molecular features, often associated either with recognizable, specific morphologies or constellations of morphologies and corresponding immunohistochemical profiles. The correct diagnosis has clinical implications leading to better prognosis, potential clinical management with targeted therapies, may identify hereditary or syndromic associations, which may necessitate appropriate genetic testing. We hope that this undertaking will further facilitate the identification of these entities in practice. We also hope that this update will bring more clarity regarding the evolving classification of renal neoplasia and will further reduce the category of "unclassifiable renal carcinomas/tumors". We propose three categories of novel entities: (1) "Novel entity", validated by multiple independent studies; (2) "Emerging entity", good compelling data available from at least two or more independent studies, but additional validation is needed; and (3) "Provisional entity", limited data available from one or two studies, with more work required to validate them. For some entities initially described using different names, we propose new terminologies, to facilitate their recognition and to avoid further diagnostic dilemmas. Following these criteria, we propose as novel entities: eosinophilic solid and cystic renal cell carcinoma (ESC RCC), renal cell carcinoma with fibromyomatous stroma (RCC FMS) (formerly RCC with leiomyomatous or smooth muscle stroma), and anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC). Emerging entities include: eosinophilic vacuolated tumor (EVT) and thyroid-like follicular renal cell carcinoma (TLFRCC). Finally, as provisional entities, we propose low-grade oncocytic tumor (LOT), atrophic kidney-like lesion (AKLL), and biphasic hyalinizing psammomatous renal cell carcinoma (BHP RCC).
- Published
- 2020
26. Renal Neoplasia in Cowden Syndrome
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Sounak Gupta and Lori A. Erickson
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Male ,medicine.medical_specialty ,business.industry ,Hamartoma ,Renal neoplasia ,PTEN Phosphohydrolase ,Disease Management ,General Medicine ,Cowden syndrome ,Middle Aged ,medicine.disease ,Kidney ,Dermatology ,Immunohistochemistry ,Medicine ,Humans ,business ,Hamartoma Syndrome, Multiple ,Carcinoma, Renal Cell - Published
- 2020
27. Educational Case: Renal Cell and Urothelial Carcinoma
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Paige Carlson and Carl T. McGary
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Kidney ,business.industry ,Cell ,education ,Renal neoplasia ,medicine.disease ,humanities ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Renal cell carcinoma ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,lcsh:Pathology ,030212 general & internal medicine ,business ,Urothelial carcinoma ,lcsh:RB1-214 - Abstract
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040 . 1
- Published
- 2020
28. Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma
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Hideki Ishida, Toshio Takagi, Satoru Morita, Yoji Nagashima, Junpei Iizuka, Kazunari Tanabe, Tsunenori Kondo, Taro Banno, Masayoshi Okumi, and Kazuhiko Yoshida
- Subjects
Adult ,Male ,medicine.medical_specialty ,Urology ,Urinary system ,030232 urology & nephrology ,Renal neoplasia ,Computed tomography ,urologic and male genital diseases ,Papillary renal cell carcinoma ,World health ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,medicine ,Humans ,sporadic [Supplementary Concept] ,Carcinoma, Renal Cell ,Tomography ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Clear cell papillary renal cell carcinoma ,medicine.disease ,Immunohistochemistry ,Diseases of the genitourinary system. Urology ,Carcinoma, Papillary ,Kidney Neoplasms ,female genital diseases and pregnancy complications ,Tumor Burden ,X-Ray Computed ,030220 oncology & carcinogenesis ,Original Article ,Female ,RC870-923 ,Radiology ,Neoplasm Grading ,Male genital organs ,Tomography, X-Ray Computed ,business ,Clear cell - Abstract
Purpose: Clear cell papillary (CCP) renal cell carcinoma (RCC) is a new subtype of RCC that was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013. Subsequently, CCP RCC was added to the 2016 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs. In this study, we retrospectively investigated the computed tomography (CT) findings of pathologically diagnosed CCP RCC. Materials and Methods: This study included 12 patients pathologically diagnosed with CCP RCC at our institution between 2015 and 2017. We reviewed the patient's CT data and analyzed the characteristics. Results: Nine solid masses and 3 cystic masses with a mean tumor size of 22.7±9.2mm were included. Solid masses exhibited slight hyper-density on unenhanced CT with a mean value of 34±6 Hounsfield units (HU), good enhancement in the corticomedullary phase with a mean of 195±34HU, and washout in the nephrogenic phase with a mean of 133±29HU. The walls of cystic masses enhanced gradually during the corticomedullary and nephrogenic phases. Solid and cystic masses were preoperatively diagnosed as clear cell RCC and cystic RCC, respectively. Conclusions: The CT imaging characteristics of CCP RCCs could be categorized into either the solid or cystic type. These masses were diagnosed radiologically as clear cell RCC and cystic RCC, respectively.
- Published
- 2020
29. The history of urologic pathology: an overview
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Robert H. Young and John N. Eble
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Male ,Urologic Diseases ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Histology ,History ,Urology ,Metanephric adenoma ,Chromophobe Renal Cell Carcinoma ,Renal neoplasia ,History, 21st Century ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Pathology, Clinical ,Testicular pathology ,World War II ,General Medicine ,History, 20th Century ,medicine.disease ,humanities ,030104 developmental biology ,030220 oncology & carcinogenesis ,Prostate gland - Abstract
This article begins with the testis and a legendary figure, Sir Astley Cooper, who wrote an early text on the organ. The early 20th century saw the first major development, the description of the seminoma by the French investigator Maurice Chevassu, but the pace of knowledge did not accelerate until after World War II with a major article from the Armed Forces Institute of Pathology (AFIP) by Nathan B. Friedman and Robert A. Moore, soon followed by the first series testis fascicle by Frank J. Dixon and Moore. Other noteworthy contributions were made by two masters of gonadal pathology, Gunnar Teilum and Robert E. Scully. In the 1970s, Niels E. Skakkebaek played a seminal role in elaborating in-situ neoplasia of the testis. The school of British testicular tumour authored, in the mid-1970s, under the editorship of Roger C. B. Pugh, one of the best texts on testicular pathology. Advances in more recent years have been largely spearheaded by Thomas M. Ulbright of the Indiana University School of Medicine. Observations on the prostate gland date back to Andreas Vesalius and William Cheselden, the latter appearing to have introduced the word for the gland. Note is made of contributions on the anatomy and histology of the gland by Oswald Lowsley, L. M. Franks, and John McNeal. Diagnosing carcinoma of the prostate was brought into the modern age in a landmark 1953 article by Robert S. Totten et al. In the 1960s, Donald F. Gleason introduced a grading system that is now in use worldwide. The topic of premalignant lesions has been well established only for approximately three decades, based initially on the work of Dr McNeal and David G. Bostwick. One of the first to write a book on the bladder was the remarkable British surgeon-pathologist Sir Henry Thompson. Workers at the AFIP, including Colonel James E. Ash and Fatallah K. Mostofi, wrote many outstanding articles on bladder pathology. The roles of other institutions, such as Johns Hopkins University, the Mayo Clinic, and St Peter's Hospital Institute of Urology, London, and those who worked there are noted. Knowledge of the pathology of the urachus dates largely back to the remarkable book on the topic in 1916 by the Hopkins investigator Thomas S. Cullen. Information on renal tumours dates largely to the work of Paul Grawitz, but awareness of the many variants of renal cell carcinoma in general was slow to evolve, and has only accelerated in recent years. The AFIP group of Dr Mostofi, ably assisted by Colonel Charles J. Davis and Isabell A. Sesterhenn, has contributed to knowledge of renal neoplasia with articles of note on oncocytoma, metanephric adenoma, and medullary carcinoma. In the mid-1980s, the German workers Wolfgang Thoenes and Stephan Störkel recognised the distinctive tumour known as chromophobe renal cell carcinoma. Work on renal tumours in the young owes much to J. Bruce Beckwith. The observational talents of numerous investigators have, in just over a century, advanced our knowledge of diseases of the urinary tract and testis remarkably.
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- 2018
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30. World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading in fine-needle aspiration biopsies of renal masses
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Carmen M. Perrino, Harvey M. Cramer, Muhammad T. Idrees, Shaoxiong Chen, and Howard H. Wu
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Pathology ,medicine.medical_specialty ,Histology ,Urology ,Concordance ,Biopsy, Fine-Needle ,030232 urology & nephrology ,Renal neoplasia ,World Health Organization ,World health ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Biopsy ,medicine ,Humans ,Grading (education) ,Societies, Medical ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Kidney Neoplasms ,Fine-needle aspiration ,Cytopathology ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Neoplasm Grading ,business - Abstract
Background Utilization of fine-needle aspiration (FNA) biopsy for the evaluation of renal masses has been increasing at our institution. At times diagnostic material on direct smears is superior to that in the cell block/core biopsy, therefore assigning an accurate nuclear grade in the cytopathology report would provide useful prognostic information. Methods Search of the pathology database identified renal FNAs performed during an 11-year period (2006-2017). Corresponding core biopsies and resections were identified. Cases with a diagnosis of primary renal neoplasia on FNA, core biopsy, and/or resection were included. Two pathologists reviewed all cases and assigned a World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grade to each FNA, core biopsy, and resection case. Results A total of 162 kidney FNAs were identified. Primary renal neoplasia was diagnosed in 137 cases on core biopsy/resection. Among diagnostic FNAs of clear cell RCC and papillary RCC with core biopsy/resection specimens for re-review (n = 52), reviewers assigned a concordant WHO/ISUP grade to 83% (43/52) of cases. Among 9 cases with discrepant scores, all had a discrepancy of 1 grade and were undergraded on FNA. Using a two tier grading system (low vs. high grade), reviewers assigned a concordant grade to 88% (46/52) of cases. Among 6 cases with discrepant scores, all were classified as low grade (WHO/ISUP grade 2) on FNA versus high grade (WHO/ISUP grade 3) on resection. Conclusion The WHO/ISUP grade assigned on FNA shows good concordance with subsequent resection/core specimens (83%), with all discrepant cases being undergraded by one grade.
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- 2018
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31. Primary leiomyosarcoma of kidney with metastasis to contralateral kidney. Case report
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Elena Enselmini Garcia Pedro, Jaime Aron García Espinoza, and Sergio Vasquez Ciriaco
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Leiomyosarcoma ,medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,Case Report ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,medicine ,metastasis ,renal leiomyosarcoma ,Kidney ,business.industry ,Incidence (epidemiology) ,renal neoplasia ,General Medicine ,medicine.disease ,Nephrectomy ,body regions ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Contralateral kidney ,Primary Leiomyosarcoma ,Renal Leiomyosarcoma ,tomographic findings ,Radiology ,business ,radical nephrectomy - Abstract
Introduction Renal leiomyosarcoma is a rare entity in the world and its understanding is based on reports and various cases; however, the prognosis is bleak for its malignant potential and an average survival of 18 months. Clinical case A 54-year-old woman with a clinical picture of 6 months of pain in the right flank and a tomographic image of a bilateral renal lesion underwent right radical nephrectomy and left conservative surgery. The definitive histopathological study reported right primary renal leiomyosarcoma with left metastasis. Conclusion Renal leiomyosarcoma is an entity of low incidence and high mortality; however, our case represents the minority of patients with contralateral kidney metastasis reported in the literature.
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- 2018
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32. Emerging entities of renal cell neoplasia
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Delahunt, Brett, Eble, John N., Egevad, Lars, Yaxley, John, Thunders, Michelle, and Samaratunga, Hemamali
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- 2019
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33. Association of Advanced Chronic Progressive Nephropathy (CPN) with Renal Tubule Tumors and Precursor Hyperplasia in Control F344 Rats from Two-Year Carcinogenicity Studies.
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Hard, Gordon C., Betz, Laura J., and Seely, John Curtis
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- *
CARCINOGENICITY , *LOGISTIC regression analysis , *KIDNEY tumors , *ANALYSIS of variance , *MULTIVARIATE analysis ,HYPERPLASIA treatment - Abstract
From the archives of the National Toxicology Program, National Institutes of Health, kidney sections from twenty-four carcinogenicity studies (representing twenty-three chemicals) in male and female F344 rats were histopathologically re-evaluated to grade the severity of chronic progressive nephropathy (CPN) on an expanded scale of 0–8, and to record the presence of renal tubule tumors (RTT) and their precursor, atypical tubule hyperplasia (ATH). The data were statistically analyzed using SAS software for logistic regression analysis. This histopathological survey of 2,436 F344 rats showed clear evidence of a qualitative and statistically significant association between advanced stages of CPN severity and the development of low-grade RTT and ATH. Advanced CPN severity therefore represents a risk factor for the development of RTT and appears to be an underlying basis for spontaneous occurrence of RTT in the F344 rat. The difference in incidence and severity of CPN between the sexes also explains the 9:1 male-to-female sex difference in the spontaneous occurrence of ATH and RTT observed here. The regulatory significance of this finding is that chemicals exacerbating CPN as their only renal effect are likely to show a numerical increase in RTT with dose, which does not represent a direct tumorigenic effect of the chemical. [ABSTRACT FROM PUBLISHER]
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- 2012
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34. Nephroblastoma in a Koi (Cyprinus carpio).
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Stegeman, Nadia, Heatley, J. Jill, Rodrigues, Aline, and Pool, Roy
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NEPHROBLASTOMA ,KOI ,CACHEXIA ,BODY cavities ,KIDNEY tumors ,VETERINARY autopsy ,CARP ,DISEASES - Abstract
Abstract: A cachexic 2-year-old koi (Cyprinus carpio) presented with progressive distension of the coelom (1-month period) and anorexia of 2 days'' duration. The fish had been maintaining a normal swimming position, although it was often observed low in the water column. Water quality was within normal limits. A skin scrape, fin clip, and gill clip were unremarkable. The respiration rate (opercular movement) was elevated at 100 breaths per minute. Blood chemistry values demonstrated a hypoalbuminemia (1.3 g/dL), elevated uric acid (1.3 mg/dL), elevated creatine kinase (>14,000 U/L), and hyperkalemia (3.9 mmol/L). Ultrasound revealed a fluid-filled coelom and a soft tissue mass containing large vessels filling most of the coelomic cavity. Fine-needle aspirates of the mass were nondiagnostic, though a poorly exfoliating mesenchymal tumor was suspected. The mass was surgically excised. Pathological examination of the mass revealed it to be a poorly demarcated and unencapsulated neoplasm forming 3 histological patterns in which a spindle cell stromal component predominated over an intermediate-sized blastema and much smaller tubular patterns. These features were most consistent with a nephroblastoma. The koi survived 5 days postoperatively but remained low in the water column and was found dead on day 6. A full necropsy of this patient was not performed. [Copyright &y& Elsevier]
- Published
- 2010
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35. Sequencing of the Von Hippel-Lindau Gene in Canine Renal Carcinoma.
- Author
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Pressler, B. M., Williams, L. E., Ramos-Vara, J. A., and Anderson, K. I.
- Subjects
- *
GENES , *RENAL cell carcinoma , *DOG diseases , *CANCER genes , *MOLECULAR biology , *ONCOLOGY - Abstract
Background: Similarities in human and canine renal cell carcinoma (RCC) epidemiology and biologic behavior suggest that molecular mechanisms of tumorigenesis may be similar in both species. Approximately 75% of RCC in people are of the clear cell subtype, up to 85% of which are associated with mutation of the von Hippel-Lindau ( VHL) gene. The canine VHL coding deoxyribonucleic acid (DNA) shares 90% identity with the human VHL gene. Objective: To determine whether or not RCC in dogs are associated with VHL mutations, and if so determine the prevalence, type, and location of these mutations. Animals: Thirteen dogs with RCC, 2 dogs with primary renal sarcomas, and 10 dogs without neoplastic kidney disease. Methods: DNA was extracted from paraffin-embedded RCC tissue; DNA extracts from paraffin-embedded and snap-frozen nonneoplastic canine kidneys and canine whole blood were used as negative controls. Polymerase chain reaction and sequencing of the 3 VHL exons was performed, and results compared with the accessioned canine sequence. Results: All VHL exons were amplified from 9 of 13 canine RCC samples, both renal sarcomas, 8 of 10 nonneoplastic kidney samples, and canine whole blood; only exon 2 could be amplified from 2 RCC samples. Mutations were not identified in any exons. A maximal prevalence of 33.6% for VHL mutations in canine RCC was determined. Conclusion and Clinical Importance: Although similarities between canine and human RCC merit further investigation of the dog as a model for some subtypes of renal tumors, the lower prevalence of VHL mutations suggests that oncogenesis in these 2 species differs. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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36. Leiomioma renal gigante benigno en una paciente inmunocompetente.
- Author
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Campuzano, Eduardo Fernández, Bribiesca, María Elena Hernández, Schjetnan, María Gómez-Palacio, Morgenstern, Rubén Drijanski, Longoria, Rafael Padilla, and Cortés, José Luis Criales
- Subjects
- *
SMOOTH muscle tumors , *MUSCLE tumors , *DISEASES in women , *ABDOMINAL pain , *MEDICAL care , *MEDICAL research - Abstract
Leiomyoma is a smooth muscle tumor with very few cases reported on the kidney. The present is a case of a giant renal leiomyoma in a 39-year-old female patient who came for evaluation of abdominal pain and who was managed by radical nephrectomy. [ABSTRACT FROM AUTHOR]
- Published
- 2008
37. New and Emerging Subtypes of Renal Cell Carcinoma
- Author
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Jae Y. Ro and Priya Rao
- Subjects
Tubulocystic renal cell carcinoma ,Kidney ,Pathology ,medicine.medical_specialty ,business.industry ,Thyroid-like follicular renal cell carcinoma ,Cell ,Renal neoplasia ,urologic and male genital diseases ,medicine.disease ,Mucinous tubular and spindle cell carcinoma ,Leiomyomatosis ,medicine.anatomical_structure ,Renal cell carcinoma ,medicine ,business ,health care economics and organizations - Abstract
Besides well-established entities of kidney tumors, there are new and emerging subtypes of renal cell carcinomas. The 2013 International Society of Urological Pathology (ISUP) Vancouver classification of adult renal neoplasia identified a category of new and emerging (or provisional new entities) entities. In this chapter, we discuss these entities except for “succinate dehydrogenase-deficient renal cell carcinoma and hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinoma,” which will be discussed in the chapter “Hereditary Syndromes-Associated Kidney Tumors.”
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- 2019
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38. Correction to: Novel, emerging and provisional renal entities: the Genitourinary Pathology Society (GUPS) update on renal neoplasia
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Sara E. Wobker, Jennifer B. Gordetsky, Virginie Verkarre, Michelle S. Hirsch, Christopher G. Przybycin, Maria S. Tretiakova, Ondrej Hes, Victor E. Reuter, Priya Rao, José I. López, Steven C. Smith, Sounak Gupta, Anthony J. Gill, Adebowale J. Adeniran, Cristina Magi-Galluzzi, Jonathan I. Epstein, Pedram Argani, Kiril Trpkov, Jesse K. McKenney, Lawrence D. True, George J. Netto, Mahul B. Amin, Ming Zhou, Reza Alaghehbandan, Liang Cheng, Santosh Menon, Eva Comperat, Isabela Werneck da Cunha, Rajal B. Shah, Fiona Maclean, Fumiyoshi Kojima, Ying-Bei Chen, Huiying He, Rola Saleeb, Satish K. Tickoo, Abbas Agaimy, John C. Cheville, Payal Kapur, Qiu Rao, Rohit Mehra, Peter A. Humphrey, and Sean R. Williamson
- Subjects
Pathology ,medicine.medical_specialty ,Genitourinary system ,business.industry ,MEDLINE ,medicine ,Renal neoplasia ,business ,Pathology and Forensic Medicine - Published
- 2021
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39. Pitfalls in the management of infantile renal neoplasia
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Abdulla S. Al Helal, Nishith K. Jetley, and Mufareh H. Al-Mazkary
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cystic nephroma ,030232 urology & nephrology ,Renal neoplasia ,cystic nephroma, infancy, liability, pyelonephritis, renal mass, Wilms tumor, xanthogranulomatous ,Wilms' tumor ,medicine.disease ,Early infancy ,Nephrectomy ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Renal mass ,medicine ,Surgery ,business - Abstract
This article addresses questions posed by a renal mass in early infancy. Are changes required in the standard approach to a renal mass in this age group? Are diagnostic possibilities transformed enough to warrant a change of approach in a setting like this? What are the ‘benign’ lesions that require consideration? What is the physician’s liability in performing a nephrectomy in a patient with a problem like this? A review of the literature suggests that the vast majority of renal space occupying lesions in children of this age are still Wilms’ tumor. Unless diagnostic refinements reach a higher level, the present protocols should be persisted with. Keywords : cystic nephroma, infancy, liability, pyelonephritis, renal mass, Wilms tumor, xanthogranulomatous
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- 2017
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40. Proliferation kinetics of streptozotocin-induced renal tumours in mice.
- Author
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Delahunt, B., Cartwright, P., Thornton, A., Dady, P., Cartwright, P R, and Dady, P J
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ADENOMA ,ANIMAL experimentation ,CANCER ,CARCINOGENS ,CELL division ,COMPARATIVE studies ,KIDNEY tumors ,RESEARCH methodology ,MEDICAL cooperation ,MICE ,RESEARCH ,SILVER staining (Microscopy) ,EVALUATION research - Abstract
Renal tumours were induced in female mice 132 days after intravenous administration of streptozotocin. The tumours exhibited papillary and/or solid architecture with papillary tumours showing no histological evidence of malignancy. Malignant behaviour, manifest as infiltration of adjacent renal tissue and lymphatic infiltration, was noted for tumours with solid architecture. Intermediate architectural forms exhibiting dual papillary and solid architecture were identified. Proliferation kinetics were evaluated by enumeration of silver-staining nucleolar organizer regions and proliferating cell nuclear antigen expression. The results showed a stepwise progress in cell proliferation between histologically normal renal tubule epithelium [untreated animals, mean AgNOR score (MAS) 2.32, mean PCNA index (MPI) 0.53%; treated animals, MAS, 2.44; MPI 0.99%], dysplastic tubule epithelium (MAS, 4.15; MPI 1.65%), papillary tumours (MAS, 5.90; MPI 3.89%) and solid tumours (MAS, 6.94; MPI, 6.80%). Solid tumours as a group were significantly larger than papillary tumours and were associated with a significantly longer mean post-injection survival interval. The findings suggest that at least some solid tumours evolve from tumours exhibiting papillary architecture. [ABSTRACT FROM AUTHOR]
- Published
- 1995
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41. Two cases of a renal epithelial tumour resembling immature nephron.
- Author
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Nagashima, Yoji, Arai, Nobutaka, Tanaka, Yukichi, Yoshida, Sachiko, Sumino, Kaoru, Ohaki, Yoshiharu, Matsushita, Kazuhiko, Morita, Takashi, and Misugi, Kazuaki
- Abstract
Two cases of renal epithelial tumours are reported in females aged 46 and 66 years respectively. In spite of the large size of the tumours, neither invasive growth nor metastasis was observed. Histologically, the tumours were composed of immature epithelial cells forming tubules with abortive glomeruloid structures. Electron microscopy of tumour cells revealed poorly developed polarity and intracytoplasmic organelles. They showed similar immunohistochemical reactions to those of developing nephrons, particularly to those of the S-shaped body. The nuclear DNA content of the tumour cells was almost euploid. We conclude that the lesions were epithelial tumours of the kidney histologically mimicking developing renal parenchyma. [ABSTRACT FROM AUTHOR]
- Published
- 1991
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42. Educational Case: Wilms Tumor
- Author
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Alison R. Huppmann
- Subjects
kidney ,Kidney ,Pathology ,medicine.medical_specialty ,business.industry ,organ system pathology ,education ,renal neoplasia ,Renal neoplasia ,Wilms tumor ,Wilms' tumor ,Educational Case ,syndrome ,medicine.disease ,humanities ,Pathology and Forensic Medicine ,pediatric ,medicine.anatomical_structure ,pathology competencies ,medicine ,lcsh:Pathology ,business ,lcsh:RB1-214 - Abstract
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040 .
- Published
- 2018
43. Diffuse Strong BCOR Immunoreactivity Is a Sensitive and Specific Marker for Clear Cell Sarcoma of the Kidney (CCSK) in Pediatric Renal Neoplasia
- Author
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Miguel Reyes-Múgica, Pedram Argani, Sara Szabo, Cristina R. Antonescu, Bruce R. Pawel, and Charles F. Timmons
- Subjects
0301 basic medicine ,Male ,Clear-cell sarcoma of the kidney ,Pathology ,medicine.medical_specialty ,Adolescent ,Renal neoplasia ,Article ,Pathology and Forensic Medicine ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Predictive Value of Tests ,Proto-Oncogene Proteins ,Biomarkers, Tumor ,Medicine ,Humans ,Extramural ,business.industry ,medicine.disease ,Immunohistochemistry ,Kidney Neoplasms ,Repressor Proteins ,030104 developmental biology ,030220 oncology & carcinogenesis ,Predictive value of tests ,Surgery ,Sarcoma ,Sarcoma, Clear Cell ,Anatomy ,business - Published
- 2018
44. Adult Renal Cell Carcinoma
- Author
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Paola Dal Cin, Michelle S. Hirsch, and Sabina Signoretti
- Subjects
medicine.medical_specialty ,business.industry ,Renal neoplasia ,Chromophobe cell ,urologic and male genital diseases ,Bioinformatics ,medicine.disease ,female genital diseases and pregnancy complications ,World health ,Pathology and Forensic Medicine ,Surgical pathology ,Mucinous tubular and spindle cell carcinoma ,Renal cell carcinoma ,Molecular genetics ,medicine ,Surgery ,business ,Clear cell - Abstract
According to the current World Health Organization (WHO), renal cell carcinomas (RCCs) that primarily affect adults are classified into 8 major subtypes. Additional emerging entities in renal neoplasia have also been recently recognized and these are discussed in further detail by Mehra et al (Emerging Entities in Renal Neoplasia, Surgical Pathology Clinics, 2015, Volume 8, Issue 4). In most cases, the diagnosis of a RCC subtype can be based on morphologic criteria, but in some circumstances the use of ancillary studies can aid in the diagnosis. This review discusses the morphologic, genetic, and molecular findings in RCCs previously recognized by the WHO, and provides clues to distinction from each other and some of the newer subtypes of RCC. As prognosis and therapeutic options vary for the different subtypes of RCC, accurate pathologic distinction is critical for patient care.
- Published
- 2015
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45. The International Society of Urological Pathology/Vancouver Classification of Renal Neoplasia: New entities of adult renal cell carcinoma
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Chin-Chen Pan
- Subjects
renal cell carcinoma ,Pathology ,medicine.medical_specialty ,Vancouver classification ,business.industry ,Urology ,Renal neoplasia ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,medicine.disease ,International Society of Urological Pathology Classification ,Renal cell carcinoma ,medicine ,business - Published
- 2015
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46. International Society of Urological Pathology Grading and Other Prognostic Factors for Renal Neoplasia
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Rodolfo Montironi, Brett Delahunt, John R. Srigley, and Lars Egevad
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,health care facilities, manpower, and services ,Urology ,education ,Consensus conference ,Renal neoplasia ,Malignancy ,medicine.disease ,medicine ,business ,Grading (tumors) ,health care economics and organizations - Abstract
The International Society of Urological Pathology convened an international consensus conference in 2012 to review aspects relating to the prognostic assessment, classification, and diagnosis of adult renal malignancy. The detailed recommendations of the conference are reported.
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- 2014
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47. The ISUP system of staging, grading and classification of renal cell neoplasia
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B. Delahunt, Troy Gianduzzo, and Hemamali Samaratunga
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medicine.medical_specialty ,Staging ,Renal neoplasia ,MEDLINE ,Review Article ,lcsh:RC870-923 ,lcsh:RC254-282 ,World health ,Renal cell carcinoma ,medicine ,International Society of Urological Pathology, ISUP ,Grading (education) ,Gynecology ,business.industry ,General surgery ,Consensus conference ,Kidney cancer ,Classification ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Grading ,Who classification ,business - Abstract
There have been significant changes in the staging, classification and grading of renal cell neoplasia in recent times. Major changes have occurred in our understanding of extra-renal extension by renal cell cancer and how gross specimens must be handled to optimally display extra-renal spread. Since the 1981 World Health Organization (WHO) classification of renal tumors, in which only a handful of different entities were reported, many new morphological types have been described in the literature, resulting in 50 different entities reported in the 2004 WHO classification. Since 2004, further new entities have been recognized and reported necessitating an update of the renal tumor classification. There have also been numerous grading systems for renal cell carcinoma with Fuhrman grading, the most widely used system. In recent times, the prognostic value and the applicability of the Fuhrman grading system in practice has been shown to be, at best, suboptimal. To address these issues and to recommend reporting guidelines, the International Society of Urological pathology (ISUP) undertook a review of adult renal neoplasia through an international consensus conference in Vancouver in 2012. The conduct of the conference was based upon evidence from the literature and the current practice amongst recognized experts in the field. Working groups selected to deal with key topics evaluated current data and identified points of controversy. A pre-meeting survey of the ISUP membership was followed by the consensus conference at which a formal ballot was taken on each key issue. A 65% majority vote was taken as consensus. This review summarizes the outcome and recommendations of this conference with regards to staging, classification and grading of renal cell neoplasia.
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- 2014
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- View/download PDF
48. International Society of Urological Pathology (ISUP) Consensus Conference on Renal Neoplasia
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Lars Egevad, Brett Delahunt, Rodolfo Montironi, and John R. Srigley
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Pathology ,medicine.medical_specialty ,business.industry ,Consensus Development Conferences as Topic ,MEDLINE ,Consensus conference ,Renal neoplasia ,Kidney Neoplasms ,Pathology and Forensic Medicine ,medicine ,Humans ,Surgery ,Anatomy ,business ,Societies, Medical - Published
- 2013
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49. Renal cell carcinoma with peritoneal carcinomatosis in a mare
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Leonardo Pereira Mesquita, Flademir Wouters, Angélica Terezinha Barth Wouters, Francisco Duque de Mesquita Neto, and Mary Suzan Varaschin
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kidney ,tumor ,Pathology ,medicine.medical_specialty ,040301 veterinary sciences ,rim ,Metastasis ,lcsh:Agriculture ,0403 veterinary science ,03 medical and health sciences ,Peritoneal cavity ,0302 clinical medicine ,Renal cell carcinoma ,medicine ,Retroperitoneal space ,Hemoperitoneum ,lcsh:Agriculture (General) ,patologia ,equine ,Kidney ,General Veterinary ,medicine.diagnostic_test ,business.industry ,lcsh:S ,renal neoplasia ,04 agricultural and veterinary sciences ,Rectal examination ,medicine.disease ,neoplasia renal ,lcsh:S1-972 ,Peritoneal carcinomatosis ,medicine.anatomical_structure ,equinos ,030220 oncology & carcinogenesis ,pathology ,Animal Science and Zoology ,medicine.symptom ,business ,Agronomy and Crop Science - Abstract
Renal cell carcinoma, especially with extensive involvement of peritoneal cavity, is rarely described in horses. This study described a case of renal cell carcinoma in an 8-year-old mare, which presented with an enlargement in the left flank, decreased appetite and straining to defecate. Clinically, a tumor in the left retroperitoneal space was detected by rectal examination and ultrasonography. The animal died after one month of clinical evolution. At necropsy, the left kidney was completely effaced by a 50cm in diameter, irregular, round, lobulated cystic mass with necro-hemorrhagic areas. Within the peritoneal cavity, there was severe hemoperitoneum and numerous sessile and pedunculated masses ranging from 2.0 to 15.0cm diameter that were attached to the visceral and parietal peritoneum. Histologically, the primary neoplasia and its metastasis were composed by a proliferation of epithelial cells, which were arranged in a tubulopapillary pattern. Diagnosis of renal cell carcinoma with peritoneal carcinomatosis and hemoperitoneum was based on macroscopic aspects, and mainly on the histological features. RESUMO: Carcinomas renais, principalmente aqueles com extenso envolvimento da cavidade peritoneal são raramente descritos na espécie equina. Este trabalho tem por objetivo descrever um carcinoma renal com carcinomatose peritoneal em um equino, fêmea, de oito anos de idade, que apresentava aumento de volume no flanco esquerdo, hiporexia e dificuldade para defecar. Clinicamente, um tumor localizado no espaço retroperitoneal esquerdo foi detectado por meio de palpação retal e exame ultrassonográfico. Após um mês de evolução clínica, o animal veio a óbito. Macroscopicamente, o rim esquerdo estava completamente obliterado por uma massa de 50,0cm de diâmetro, irregular, lobulada e com áreas císticas e necro-hemorrágicas. Na cavidade peritoneal, havia hemoperitônio acentuado e inúmeras massas sésseis e pedunculadas, de 2,0 a 15,0cm de diâmetro, estavam aderidas às porções parietal e visceral do peritônio. Histologicamente, a neoplasia primária e suas metástases eram constituídas principalmente pela proliferação de células epiteliais, as quais formavam estruturas túbulo-papilares. O diagnóstico de carcinoma renal com carcinomatose peritoneal, associado a hemoperitônio foi baseado nos achados macroscópicos e, principalmente, histológicos da neoplasia.
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- 2017
- Full Text
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50. The Tumor Entity Denominated 'clear cell-papillary renal cell carcinoma' According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome
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Alessandro D'Amuri, Camillo Porta, Roberto Sabbatini, Giampaolo Tortora, Cinzia Ortega, Ondrej Hes, Annalisa Guida, Luca Cima, Andrea Ardizzoni, Michal Michal, Alberto Lapini, Michelangelo Fiorentino, Francesca Giunchi, Francesco Massari, Francesca Sanguedolce, Chiara Ciccarese, Roberto Iacovelli, Matteo Brunelli, Anna Caliò, Guido Martignoni, Massari, Francesco, Ciccarese, Chiara, Hes, Ondrej, Michal, Michal, Caliò, Anna, Fiorentino, Michelangelo, Giunchi, Francesca, D’Amuri, Alessandro, Sanguedolce, Francesca, Sabbatini, Roberto, Guida, Annalisa, Ardizzoni, Andrea, Porta, Camillo, Iacovelli, Roberto, Tortora, Giampaolo, Cima, Luca, Ortega, Cinzia, Lapini, Alberto, Martignoni, Guido, and Brunelli, Matteo
- Subjects
0301 basic medicine ,Adenoma ,Cancer Research ,Pathology ,medicine.medical_specialty ,Renal adenoma ,Renal neoplasia ,Renal cell adenoma ,urologic and male genital diseases ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Carcinoma, Renal Cell ,Neoplasm Staging ,Benign ,Clear cell papillary RCC ,Renal adenomatoid tumour (RAT) ,WHO 2016 classification of renal neoplasia ,business.industry ,General Medicine ,Clear cell papillary renal cell carcinoma ,medicine.disease ,Carcinoma, Papillary ,Kidney Neoplasms ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Neoplasm staging ,business ,Clear cell - Abstract
The new WHO 2016 classification of renal neoplasia encounters the new entity called âclear cell papillary renal cell carcinomaâ (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histotype and it actually ranges from 2 to 9% in different routinely available cohort of renal carcinomas. Of important note, ccpRCC does not show any recurrences or metastases or lymph-node invasion and the outcome is always good. We reviewed twenty-four publications with available follow-up for patients (no. 362) affected by clear cell papillary RCCs/renal adenomatoid tumours and notably ccpRCC harbors an indolent clinical behavior after a mean of 38 months (3,5 years) of follow-up. This paper reviews the histological, molecular and clinical features characterizing ccpRCC, with the goal of focusing the knowledge of the benign fashion of this new tumour entity, supporting the idea of a new renal cell adenoma recruited morphologically from ex conventional clear cell RCC tumours.
- Published
- 2016
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