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1. Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiation

Author

Jonchère, Vincent, Montémont, Hugo, Le Scanf, Enora, Siret, Aurélie, Letourneur, Quentin, Tubacher, Emmanuel, Battail, Christophe, Fall, Assane, Labreche, Karim, Renault, Victor, Ratovomanana, Toky, Buhard, Olivier, Jolly, Ariane, Le Rouzic, Philippe, Feys, Cody, Despras, Emmanuelle, Zouali, Habib, Nicolle, Rémy, Cervera, Pascale, Svrcek, Magali, Bourgoin, Pierre, Blanché, Hélène, Boland, Anne, Lefèvre, Jérémie, Parc, Yann, Touat, Mehdi, Bielle, Franck, Arzur, Danielle, Cueff, Gwennina, Le Jossic-Corcos, Catherine, Quéré, Gaël, Dujardin, Gwendal, Blondel, Marc, Le Maréchal, Cédric, Cohen, Romain, André, Thierry, Coulet, Florence, de la Grange, Pierre, de Reyniès, Aurélien, Fléjou, Jean-François, Renaud, Florence, Alentorn, Agusti, Corcos, Laurent, Deleuze, Jean-François, Collura, Ada, and Duval, Alex

Published
2024
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2. Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre study

Author

Bournet, Barbara, Canivet, Cindy, Buscail, Louis, Carrère, Nicolas, Muscari, Fabrice, Suc, Bertrand, Guimbaud, Rosine, Couteau, Corinne, Deslandres, Marion, Rivera, Pascale, Alouany, Emily, Fares, Nadim, Barange, Karl, Selves, Janick, Gomez-Brouchet, Anne, Culetto, Adrian, Le Cosquer, Guillaume, Jaffrelot, Marion, Napoléon, Bertrand, Pujol, Bertrand, Fumex, Fabien, Desrame, Jérôme, Lefort, Christine, Lepilliez, Vincent, Gincul, Rodica, Artru, Pascal, Clavel, Léa, Lemaistre, Anne-Isabelle, Palazzo, Laurent, Cros, Jérôme, Tubiana, Sarah, Flori, Nicolas, Senesse, Pierre, Colombo, Pierre-Emmanuel, Samalin-Scalzi, Emmanuelle, Portales, Fabienne, Gourgou, Sophie, Roca, Lise, Ga, Claire Honfo, Plassot, Carinne, Ychou, Marc, Guibert, Pierre, De La Fouchardière, Christelle, Sarabi, Mathieu, Peyrat, Patrice, Tabone-Eglinger, Séverine, Renard, Caroline, Piessen, Guillaume, Truant, Stéphanie, Saudemont, Alain, Millet, Guillaume, Renaud, Florence, Leteurtre, Emmanuelle, Gelé, Patrick, Assenat, Eric, Fabre, Jean-Michel, Souche, François-Régis, Dupuy, Marie, Gorce-Dupuy, Anne-Marie, Ramos, Jeanne, Seitz, Jean-François, Hardwigsen, Jean, Norguet-Monnereau, Emmanuelle, Grandval, Philippe, Duluc, Muriel, Figarella-Branger, Dominique, Vendrely, Véronique, Subtil, Clément, Terrebonne, Eric, Blanc, Jean-Frédéric, Merlio, Jean-Philippe, Farges-Bancel, Dominique, Gornet, Jean-Marc, Geromin, Daniela, Vanbiervliet, Geoffroy, Frin, Anne-Claire, Ouvrier, Delphine, Saint-Paul, Marie-Christine, Berthélémy, Philippe, Fouad, Chelbabi, Garcia, Stéphane, Lesavre, Nathalie, Gasmi, Mohamed, Barthet, Marc, Cottet, Vanessa, Delpierre, Cyrille, Nicolle, Rémy, Ayadi, Mira, Pignolet, Camille, Torrisani, Jérôme, Dusetti, Nelson, and Cordelier, Pierre

Published
2024
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3. Comparison of the Wechsler Preschool and Primary Scale of Intelligence--Third Edition and the Leiter-R Intellectual Assessments for Clinic-Referred Children

Author

Renaud, Florence, Béliveau, Marie-Julie, Akzam-Ouellette, Marc-Antoine, Jauvin, Karine, and Labelle, Fannie

Abstract

A review of clinical records was conducted for children with developmental, emotional, and behavioral difficulties who were assessed with both the Wechsler preschool and primary scale of intelligence-third edition (WPPSI-III[superscript CDN]; Wechsler, 2004) and the Leiter international performance scale--revised (Leiter-R; Roid & Miller, 1997) within the same psychological evaluation. Forty children, ages 3-7, were included in this study. Pearson correlations showed that the IQ scores of the two instruments are strongly related (r > 0.70; p < 0.001). However, paired t-tests showed that overall Leiter-R scores (M = 99.03) were significantly higher than WPPSI-III[superscript CDN] scores (PIQ; M = 82.28, FSIQ; M = 75.24) (p < 0.001). The discrepancies between the instrument's scores were clinically important as the use of only one of the two instruments could result in misclassification of child intellectual ability. These results should prompt professionals working with this clinical population to be cautious when using results from a single instrument in a child's intellectual evaluation.

Published
2022
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8. Student’s self-reported experience of soundscape: The link between noise, psychological and physical well-being

Author

Renaud, Florence, Verduyckt, Ingrid, Chang, Tiffany, Lacerda, Adriana, Borges, Cecilia, Bockstael, Annelies, Bouserhal, Rachel E., Renaud, Florence, Verduyckt, Ingrid, Chang, Tiffany, Lacerda, Adriana, Borges, Cecilia, Bockstael, Annelies, and Bouserhal, Rachel E.

Abstract

Extensive research has shown that noise has detrimental effects on learning in classrooms, yet schools remain noisy environments. In addition, little is known about the students’ insight into their subjective reaction to noise. Students’ awareness of noise, as well as their perception of its effects on their affective and bodily states, remain unanswered. In the current study, the self-reported experience of noise and reaction towards noise, which was collected by way of a questionnaire, was assessed for 408 students in primary and secondary schools in Québec. Results suggest that about half of the students experience affective and bodily reactions to noise, and students who report having a negative affective reaction to noise are also more prone to report feeling this noise in their bodies. The results of this study offer a comprehensive picture of the students’ subjective (affective and bodily) state in relation to noise in schools.

Published
2024

9. Management of Pathogenic CDH1 Variant Carriers Within the FREGAT Network: A Multicentric Retrospective Study

Author

Bres, Capucine, Voron, Thibault, Benhaim, Leonor, Bergeat, Damien, Parc, Yann, Karoui, Mehdi, Genser, Laurent, Pe[Combining Acute Accent]re[Combining Acute Accent], Guillaume, Demma, Jonathan A., Bacoeur-Ouzillou, Ophe[Combining Acute Accent]lie, Lebreton, Gil, Thereaux, Jeremie, Gronnier, Caroline, Dartigues, Peggy, Svrcek, Magali, Bouzille[Combining Acute Accent], Guillaume, Bardier, Armelle, Brunac, Anne C., Roche, Brigitte, Darcha, Claude, Bazille, Celine, Doucet, Laurent, Belleannee, Genevieve, Lejeune, Sophie, Buisine, Marie P., Renaud, Florence, Nuytens, Frederiek, Benusiglio, Patrick R., Veziant, Julie, Eveno, Clarisse, and Piessen, Guillaume

Published
2022
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11. Association Between Microscopic Lesions at Ileal Resection Margin and Recurrence After Surgery in Patients With Crohn’s Disease

Author

Cattan, Pierre, Chirica, Mircea, Munoz-Bongrand, Nicolas, Corte, Hélène, Beaupel, Nathan, Catry, Jonathan, Gornet, Jean-Marc, Baudry, Clotilde, Lourenco, Nelson, Maillet, Mariane, Tran-Minh, My-Linh, Chardiny, Victor, Grand, Céline, Gergaud, Brice, Bonnet, Joelle, Chedouba, Leila, Nisard, Andrée, Beaugerie, Laurent, Sokol, Harry, Bourrier, Anne, Nion-Larmurier, Isabelle, Kirchgesner, Julien, Quevrain, Elodie, Brot, Loic, Chafai, Najim, Lefevre, Jeremie H., Tiret, Emmanuel, Svrcek, Magali, Guedj, Nathalie, Panis, Yves, Magiorri, Leon, Ferron, Marianne, Bouhnik, Yoram, Corcos, Olivier, Stefanescu, Carmen, Marteau, Philippe, Dray, Xavier, Chaput, Ulrika, Kaci, Rachid, Dubois, Anne, Bommelaer, Gilles, Goutte, Marion, Barnich, Nicolas, Coban, Dilek, Godfraind, Catherine, Zakeyh, Juliette Joubert, Desreumaux, Pierre, Nachury, Maria, Sommeville, Coralie, Renaud, Florence, Dupas, Jean-Louis, Loreau, Julien, Brazier, Franck, Chatelain, Denis, Attencourt, Christophe, Sabbagh, Charles, Leconte, Martine, Boschetti, Gilles, Flourié, Bernard, François, Yves, Cotte, Eddy, Charlois, Anne-Laure, Falgon, Peggy, Hadjisavvas, Helena, Moussata, Driffa, Chauvenet, Marion, Boyer, Sarah, Traverse-Glehen, Alexandra, Hebuterne, Xavier, Filippi, Jérome, Hofmann, Paul, Rahili, Amine, Patouraux, Stéphanie, Jouven, Xavier, Hammoudi, Nassim, Cazals-Hatem, Dominique, Auzolle, Claire, Gardair, Charlotte, Ngollo, Marjolaine, Bottois, Hugo, Nancey, Stéphane, Pariente, Benjamin, Buisson, Anthony, Treton, Xavier, Fumery, Mathurin, Bezault, Madeleine, Seksik, Philippe, Le Bourhis, Lionel, Flejou, Jean-François, and Allez, Matthieu

Published
2020
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19. Salvage Surgery for Esophageal Cancer: How to Improve Outcomes?

Author

Cohen, Charlotte, Tessier, Williams, Gronnier, Caroline, Renaud, Florence, Pasquer, Arnaud, Théreaux, Jérémie, Gagnière, Johan, Meunier, Bernard, Collet, Denis, Piessen, Guillaume, Mariette, Christophe, and FREGAT (French Eso-Gastric Tumors working group) – FRENCH (Fédération de Recherche en Chirurgie) – AFC (Association Française de Chirurgie)

Published
2018
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25. Comparing MS imaging of lipids by WALDI and MALDI: two technologies for evaluating a common ground truth in MS imaging.

Author

Ledoux, Léa, Zirem, Yanis, Renaud, Florence, Duponchel, Ludovic, Salzet, Michel, Ogrinc, Nina, and Fournier, Isabelle

Subjects
PEARSON correlation (Statistics), IONS spectra, RADIANT intensity, ANIONS, TISSUE analysis
Abstract

In this study, we conducted a direct comparison of water-assisted laser desorption ionization (WALDI) and matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging, with MALDI serving as the benchmark for label-free molecular tissue analysis in biomedical research. Specifically, we investigated the lipidomic profiles of several biological samples and calculated the similarity of detected peaks and Pearson's correlation of spectral profile intensities between the two techniques. We show that, overall, MALDI MS and WALDI MS present very close lipidomic analyses and that the highest similarity is obtained for the norharmane MALDI matrix. Indeed, for norharmane in negative ion mode, the lipidomic spectra revealed 100% similarity of detected peaks and over 0.90 intensity correlation between both technologies for five samples. The MALDI-MSI positive ion lipid spectra displayed more than 83% similarity of detected peaks compared to those of WALDI-MSI. However, we observed a lower percentage (77%) of detected peaks when comparing WALDI-MSI with MALDI-MSI due to the rich WALDI-MSI lipid spectra. Despite this difference, the global lipidomic spectra showed high consistency between the two technologies, indicating that they are governed by similar processes. Thanks to this similarity, we can increase datasets by including data from both modalities to either co-train classification models or obtain cross-interrogation. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Discrepancy Between Clinical and Pathologic Nodal Status of Esophageal Cancer and Impact on Prognosis and Therapeutic Strategy

Author

Markar, Sheraz R., Gronnier, Caroline, Pasquer, Arnaud, Duhamel, Alain, Behal, Hélène, Théreaux, Jérémie, Gagnière, Johan, Lebreton, Gil, Brigand, Cécile, Renaud, Florence, Piessen, Guillaume, Meunier, Bernard, Collet, Denis, Mariette, Christophe, Luc, Guillaume, Cabau, Magalie, Jougon, Jacques, Badic, Bogdan, Lozach, Patrick, Nakadi, Issam El, Cappeliez, Serge, Lebreton, Gil, Lubrano, Jean, Alves, Arnaud, Flamein, Renaud, Pezet, Denis, Pipitone, Federica, Iuga, Bogdan Stan, Contival, Nicolas, Pappalardo, Eric, Mantziari, Styliani, Demartines, Nicolas, Hec, Flora, Vanderbeken, Marguerite, Degisors, Sébastien, Marin, Hélène, Fredon, Fabien, Gainant, Alain, Mathonnet, Muriel, Bigourdan, Jean-Marc, Mezoughi, Salim, Mabrut, Jean-Yves, Ducerf, Christian, Baraket, Oussama, Poncet, Gilles, Vaudoyer, Delphine, Enfer, Peggy Jourdan, Villeneuve, Laurent, Glehen, Olivier, Coste, Thibault, Fabre, Jean Michel, Marchal, Frédéric, Frisoni, Romain, Ayav, Ahmet, Brunaud, Laurent, Bresler, Laurent, Cohen, Charlotte, Aze, Olivier, Venissac, Nicolas, Pop, Daniel, Mouroux, Jérôme, Donici, Ion, Prudhomme, Michel, Felli, Emanuele, Lisunfui, Stéphanie, Seman, Marie, Petit, Gaelle Godiris, Karoui, Mehdi, Tresallet, Christophe, Ménégaux, Fabrice, Malgras, Brice, Lantuas, Denis, Pautrat, Karine, Pocard, Marc, and on Behalf of the FREGAT Working Group—FRENCH—AFC

Published
2017
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28. Associations between the severity of medical and surgical complications and perception of surgeon empathy in esophageal and gastric cancer patients

Author

Gehenne, Lucie, Lelorain, Sophie, Eveno, Clarisse, Piessen, Guillaume, Mariette, Christophe, Glehen, Olivier, d'Journo, Xavier, Mathonnet, Muriel, Regenet, Nicolas, Meunier, Bernard, Baudry, Anne-Sophie, Christophe, Véronique, Adenis, Antoine, Aparicio, Thomas, Assenat, Eric, Barret, Maximilien, Benhaim, Leonor, Benoit, Céline, Bergeat, Damien, Boige, Valérie, Borie, Fréderic, Bouche, Olivier, Bourriez, Damien, Brichon, Pierre-Yves, Brigand, Cécile, Carrere, Nicolas, Cattan, Pierre, Christou, Niki, Coffin, Benoit, Cohen, Romain, Collet, Denis, Conroy, Thierry, Dahan, Laetitia, Deguelte, Sophie, Di Fiore, Fréderic, Dousset, Bertrand, Drouillard, Antoine, Dumont, Frédéric, Elhajbi, Farid, Fabre, Jean Michel, Fabre, Joseph, Gagniere, Johan, Galais, Marie Pierre, Germain, Adeline, Geyl, Sophie, Goere, Diane, Gornet, Jean Marc, Granger, Victoire, Gronnier, Caroline, Guimbaud, Rosine, Hautefeuille, Vincent, Helyon, Morgane, Jougon, Jacques, Lebreton, Gilles, Lefevre, Jérémie, Lepage, Côme, Lievre, Astrid, Marchal, Frédéric, Mathieu, Pierre, Mathysiak, Tamara, Michot, Nicolas, Moszkowicz, David, Moussata, Driffa, Msika, Simon, Neuzillet, Cindy, Ouaissi, Medhi, Paquette, Brice, Paye, François, Penna, Christophe, Père, Guillaume, Perrier, Marine, Peschaud, Frédérique, Pezet, Denis, Phoutthsang, Valérie, Pocard, Marc, Rat, Paul, Regimbeau, Jean Marc, Renaud, Florence, Sabate, Jean-Marc, Souche, Régis, Terrebonne, Eric, Tessier, Williams, Thomas, Pascal Alexandre, Turpin, Anthony, Vaudoyer, Delphine, Vienot, Angélique, Voron, Thibault, You, Benoit, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Centre hospitalier [Valenciennes, Nord], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Esophageal Neoplasms, media_common.quotation_subject, education, [SDV.CAN]Life Sciences [q-bio]/Cancer, Empathy, MESH: Perception, Odds, Postoperative complications, MESH: Surgeons, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Perception, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Major complication, Retrospective Studies, Cancer, media_common, Multinomial logistic regression, Surgeons, Physician-Patient Relations, MESH: Humans, business.industry, Nursing research, MESH: Retrospective Studies, Cognition, MESH: Stomach Neoplasms, medicine.disease, Patient-physician communication, MESH: Empathy, Oncology, 030220 oncology & carcinogenesis, MESH: Esophageal Neoplasms, MESH: Physician-Patient Relations, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Objective: To assess the impact of global physician empathy and its three subdimensions (establishing rapport, emotional and cognitive processes) on the severity of postoperative complications in a sample of cancer patients.Methods: We retrospectively analyzed data on 256 patients with esogastric cancer from the French national FREGAT database. Empathy and its subdimensions were assessed using the patient-reported CARE scale and the severity of medical and surgical complications was reported with the Clavien-Dindo classification system. The usual covariates were included in multinomial logistic regression analyses.Results: Physician empathy predicted the odds of reporting major complications. When patients perceived high empathy, they were less likely to report major complications compared to no complications (OR = .95, 95% CI = [.91-.99], p = .029). Among the three dimensions, only "establishing rapport" (OR = .84, 95% CI = [.73-.98], p = .019) and the "emotional process" (OR = .85, 95% CI = [.74-.98], p = .022) predicted major complications.Conclusions: Physician empathy is essential before surgery. Further research is needed to understand the mechanisms associating empathy with health outcomes in cancer. Physicians should be trained to establish good rapport with patients, especially in the preoperative period.

Published
2021

31. NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia

Author

Coutelier, Marie, Jacoupy, Maxime, Janer, Alexandre, Renaud, Florence, Auger, Nicolas, Saripella, Ganapathi-Varma, Ancien, François, Pucci, Fabrizio, Rooman, Marianne, Gilis, Dimitri, Larivière, Roxanne, Sgarioto, Nicolas, Valter, Rémi, Guillot-Noel, Léna, Le Ber, Isabelle, Sayah, Sabrina, Charles, Perrine, Nümann, Astrid, Pauly, Martje G, Helmchen, Christoph, Deininger, Natalie, Haack, Tobias, Brais, Bernard, Brice, Alexis, Trégouët, David-Alexandre, El Hachimi, Khalid, Shoubridge, Eric, Durr, Alexandra, Stevanin, Giovanni, Coutelier, Marie, Jacoupy, Maxime, Janer, Alexandre, Renaud, Florence, Auger, Nicolas, Saripella, Ganapathi-Varma, Ancien, François, Pucci, Fabrizio, Rooman, Marianne, Gilis, Dimitri, Larivière, Roxanne, Sgarioto, Nicolas, Valter, Rémi, Guillot-Noel, Léna, Le Ber, Isabelle, Sayah, Sabrina, Charles, Perrine, Nümann, Astrid, Pauly, Martje G, Helmchen, Christoph, Deininger, Natalie, Haack, Tobias, Brais, Bernard, Brice, Alexis, Trégouët, David-Alexandre, El Hachimi, Khalid, Shoubridge, Eric, Durr, Alexandra, and Stevanin, Giovanni

Abstract

With more than forty causative genes identified so far, autosomal dominant cerebellar ataxias exhibit a remarkable genetic heterogeneity. Yet, half the patients are lacking a molecular diagnosis. In a large family with nine sampled affected members, we performed exome sequencing combined with whole-genome linkage analysis. We identified a missense variant in NPTX1, NM_002522.3: c.1165G>A: p.G389R, segregating with the phenotype. Further investigations with whole exome sequencing and an amplicon-based panel identified four additional unrelated families segregating the same variant, for whom a common founder effect could be excluded. A second missense variant, NM_002522.3: c.980A>G: p.E327G, was identified in a fifth familial case. The NPTX1-associated phenotype consists of a late-onset, slowly progressive, cerebellar ataxia, with downbeat nystagmus, cognitive impairment reminiscent of cerebellar cognitive affective syndrome, myoclonic tremor and mild cerebellar vermian atrophy on brain imaging. NPTX1 encodes the neuronal pentraxin 1, a secreted protein with various cellular and synaptic functions. Both variants affect conserved amino-acid residues and are extremely rare or absent from public databases. In COS7 cells, overexpression of both neuronal pentraxin 1 variants altered endoplasmic reticulum morphology and induced ATF6-mediated endoplasmic reticulum stress, associated with cytotoxicity. In addition, the p. E327G variant abolished neuronal pentraxin 1 secretion, as well as its capacity to form a high molecular weight complex with the wild-type protein. Co-immunoprecipitation experiments coupled with mass spectrometry analysis demonstrated abnormal interactions of this variant with the cytoskeleton. In agreement with these observations, in silico modelling of the neuronal pentraxin 1 complex evidenced a destabilizing effect for the p. E327G substitution, located at the interface between monomers. On the contrary, the p. G389 residue, located at th, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

34. Prediction of Response to Immune Checkpoint Blockade in Patients with Metastatic Colorectal Cancer with Microsatellite Instability

Author

Duval, Alex, primary, Ratovomanana, Toky, additional, Nicolle, Remy, additional, Cohen, Romain, additional, Diehl, Aurélien, additional, Siret, Aurélie, additional, Letourneur, Quentin, additional, Buhard, Olivier, additional, Perrier, Alexandre, additional, Guillerm, Erell, additional, Coulet, Florence, additional, Colle, Raphaël, additional, Collura, Ada, additional, Despras, Emmanuelle, additional, Rouzic, Philippe Le, additional, Renaud, Florence, additional, Alentorn, Agusti, additional, Touat, Mehdi, additional, Ayadi, Mira, additional, Bourgoin, Pierre, additional, Prunier, Celine, additional, Jonchère, Vincent, additional, Bennouna, Jaafar, additional, de Reynies, Aurélien, additional, Fléjou, Jean-François, additional, Svrcek, Magali, additional, and André, Thierry, additional

Published
2022
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37. Performance of Next-Generation Sequencing for the Detection of Microsatellite Instability in Colorectal Cancer With Deficient DNA Mismatch Repair

Author

Ratovomanana, Toky, primary, Cohen, Romain, additional, Svrcek, Magali, additional, Renaud, Florence, additional, Cervera, Pascale, additional, Siret, Aurélie, additional, Letourneur, Quentin, additional, Buhard, Olivier, additional, Bourgoin, Pierre, additional, Guillerm, Erell, additional, Dorard, Coralie, additional, Nicolle, Remy, additional, Ayadi, Mira, additional, Touat, Mehdi, additional, Bielle, Franck, additional, Sanson, Marc, additional, Le Rouzic, Philippe, additional, Buisine, Marie-Pierre, additional, Piessen, Guillaume, additional, Collura, Ada, additional, Fléjou, Jean-François, additional, de Reyniès, Aurélien, additional, Coulet, Florence, additional, Ghiringhelli, François, additional, André, Thierry, additional, Jonchère, Vincent, additional, and Duval, Alex, additional

Published
2021
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39. CARMN‐NOTCH2fusion transcript drives highNOTCH2expression in glomus tumors of the upper digestive tract

Author

Girard, Nicolas, primary, Marin, Cristi, additional, Hélias‐Rodzewicz, Zofia, additional, Villa, Chiara, additional, Julié, Catherine, additional, Lajarte‐Thirouard, Anne‐Sophie, additional, Beauce, Simon Martin, additional, Lagorce‐Pages, Christine, additional, Renaud, Florence, additional, Cazals‐Hatem, Dominique, additional, Guedj, Nathalie, additional, Cros, Jérome, additional, Raffin‐Sanson, Marie‐Laure, additional, Selves, Janick, additional, Terris, Benoit, additional, Fléjou, Jean‐François, additional, Garchon, Henri‐Jean, additional, Coindre, Jean‐Michel, additional, and Emile, Jean‐François, additional

Published
2021
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43. Incidence of Venous Thromboembolism in Patients With Newly Diagnosed Pancreatic Cancer and Factors Associated With Outcomes

Author

Frere, Corinne, primary, Bournet, Barbara, additional, Gourgou, Sophie, additional, Fraisse, Julien, additional, Canivet, Cindy, additional, Connors, Jean M., additional, Buscail, Louis, additional, Farge, Dominique, additional, Carrère, Nicolas, additional, Muscari, Fabrice, additional, Suc, Bertrand, additional, Guimbaud, Rosine, additional, Couteau, Corinne, additional, Deslandres, Marion, additional, Rivera, Pascale, additional, Laurenty, Anne-Pascale, additional, Fares, Nadim, additional, Barange, Karl, additional, Selves, Janick, additional, Gomez-Brouchet, Anne, additional, Napoléon, Bertrand, additional, Pujol, Bertrand, additional, Fumex, Fabien, additional, Desrame, Jérôme, additional, Lefort, Christine, additional, Lepilliez, Vincent, additional, Gincul, Rodica, additional, Artru, Pascal, additional, Clavel, Léa, additional, Lemaistre, Anne-Isabelle, additional, Palazzo, Laurent, additional, Cros, Jérôme, additional, Tubiana, Sarah, additional, Flori, Nicolas, additional, Senesse, Pierre, additional, Colombo, Pierre-Emmanuel, additional, Samail-Scalzi, Emmanuelle, additional, Portales, Fabienne, additional, Ga, Claire Honfo, additional, Plassot, Carine, additional, Bibeau, Frédéric, additional, Ychou, Marc, additional, Guibert, Pierre, additional, Fouchardière, Christelle de la, additional, Sarabi, Matthieu, additional, Peyrat, Patrice, additional, Tabone-Eglinger, Séverine, additional, Renard, Caroline, additional, Piessen, Guillaume, additional, Truant, Stéphanie, additional, Saudemont, Alain, additional, Millet, Guillaume, additional, Renaud, Florence, additional, Leteurtre, Emmanuelle, additional, Gele, Patrick, additional, Assenat, Eric, additional, Fabre, Jean-Michel, additional, Souche, François-Régis, additional, Dupuy, Marie, additional, Gorce-Dupuy, Anne-Marie, additional, Ramos, Jeanne, additional, Seitz, Jean-François, additional, Hardwigsen, Jean, additional, Norguet-Monnereau, Emmanuelle, additional, Grandval, Philippe, additional, Duluc, Muriel, additional, Figarella-Branger, Dominique, additional, Vendrely, Véronique, additional, Subtil, Clément, additional, Terrebonne, Eric, additional, Blanc, Jean-Frédéric, additional, Buscail, Etienne, additional, Merlio, Jean-Philippe, additional, Gornet, Jean-Marc, additional, Geromin, Daniela, additional, Vanbiervliet, Geoffroy, additional, Frin, Anne-Claire, additional, Ouvrier, Delphine, additional, Saint-Paul, Marie-Christine, additional, Berthelémy, Philippe, additional, Fouad, Chelbabi, additional, Garcia, Stéphane, additional, Lesavre, Nathalie, additional, Gasmi, Mohamed, additional, Barthet, Marc, additional, Cottet, Vanessa, additional, and Delpierre, Cyrille, additional

Published
2020
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44. The amount of signet ring cells is significantly associated with tumour stage and survival in gastric poorly cohesive tumours

Author

Bencivenga, Maria, primary, Treppiedi, Elio, additional, Dal Cero, Mariagiulia, additional, Torroni, Lorena, additional, Verlato, Giuseppe, additional, Iglesias, Mar, additional, Renaud, Florence, additional, Tomezzoli, Anna, additional, Castelli, Claudia, additional, Piessen, Guillaume, additional, Pera, Manuel, additional, and Manzoni, Giovanni, additional

Published
2020
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45. Association Between Microscopic Lesions at Ileal Resection Margin and Recurrence After Surgery in Patients With Crohn’s Disease

Author

Hammoudi, Nassim, primary, Cazals-Hatem, Dominique, additional, Auzolle, Claire, additional, Gardair, Charlotte, additional, Ngollo, Marjolaine, additional, Bottois, Hugo, additional, Nancey, Stéphane, additional, Pariente, Benjamin, additional, Buisson, Anthony, additional, Treton, Xavier, additional, Fumery, Mathurin, additional, Bezault, Madeleine, additional, Seksik, Philippe, additional, Le Bourhis, Lionel, additional, Flejou, Jean-François, additional, Allez, Matthieu, additional, Cattan, Pierre, additional, Chirica, Mircea, additional, Munoz-Bongrand, Nicolas, additional, Corte, Hélène, additional, Beaupel, Nathan, additional, Catry, Jonathan, additional, Gornet, Jean-Marc, additional, Baudry, Clotilde, additional, Lourenco, Nelson, additional, Maillet, Mariane, additional, Tran-Minh, My-Linh, additional, Chardiny, Victor, additional, Grand, Céline, additional, Gergaud, Brice, additional, Bonnet, Joelle, additional, Chedouba, Leila, additional, Nisard, Andrée, additional, Beaugerie, Laurent, additional, Sokol, Harry, additional, Bourrier, Anne, additional, Nion-Larmurier, Isabelle, additional, Kirchgesner, Julien, additional, Quevrain, Elodie, additional, Brot, Loic, additional, Chafai, Najim, additional, Lefevre, Jeremie H., additional, Tiret, Emmanuel, additional, Svrcek, Magali, additional, Guedj, Nathalie, additional, Panis, Yves, additional, Magiorri, Leon, additional, Ferron, Marianne, additional, Bouhnik, Yoram, additional, Corcos, Olivier, additional, Stefanescu, Carmen, additional, Marteau, Philippe, additional, Dray, Xavier, additional, Chaput, Ulrika, additional, Kaci, Rachid, additional, Dubois, Anne, additional, Bommelaer, Gilles, additional, Goutte, Marion, additional, Barnich, Nicolas, additional, Coban, Dilek, additional, Godfraind, Catherine, additional, Zakeyh, Juliette Joubert, additional, Desreumaux, Pierre, additional, Nachury, Maria, additional, Sommeville, Coralie, additional, Renaud, Florence, additional, Dupas, Jean-Louis, additional, Loreau, Julien, additional, Brazier, Franck, additional, Chatelain, Denis, additional, Attencourt, Christophe, additional, Sabbagh, Charles, additional, Leconte, Martine, additional, Boschetti, Gilles, additional, Flourié, Bernard, additional, François, Yves, additional, Cotte, Eddy, additional, Charlois, Anne-Laure, additional, Falgon, Peggy, additional, Hadjisavvas, Helena, additional, Moussata, Driffa, additional, Chauvenet, Marion, additional, Boyer, Sarah, additional, Traverse-Glehen, Alexandra, additional, Hebuterne, Xavier, additional, Filippi, Jérome, additional, Hofmann, Paul, additional, Rahili, Amine, additional, Patouraux, Stéphanie, additional, and Jouven, Xavier, additional

Published
2020
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46. A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms.

Author

Hadj Bachir, Elsa, Poiraud, Charles, Paget, Sonia, Stoup, Nicolas, El Moghrabi, Soumaya, Duchêne, Belinda, Jouy, Nathalie, Bongiovanni, Antonino, Tardivel, Meryem, Weiswald, Louis‐Bastien, Vandepeutte, Marie, Beugniez, César, Escande, Fabienne, Leteurtre, Emmanuelle, Poulain, Laurent, Lagadec, Chann, Pigny, Pascal, Jonckheere, Nicolas, Renaud, Florence, and Truant, Stephanie

Subjects
CANCER chemotherapy, DRUG resistance in cancer cells, PROGNOSIS, DRUG resistance, DRUG therapy, ANTIMETABOLITES
Abstract

Background Information: Although improvements have been made in the management of pancreatic adenocarcinoma (PDAC) during the past 20 years, the prognosis of this deadly disease remains poor with an overall 5‐year survival under 10%. Treatment with FOLFIRINOX, a combined regimen of 5‐fluorouracil, irinotecan (SN‐38) and oxaliplatin, is nonetheless associated with an excellent initial tumour response and its use has allowed numerous patients to go through surgery while their tumour was initially considered unresectable. These discrepancies between initial tumour response and very low long‐term survival are the consequences of rapidly acquired chemoresistance and represent a major therapeutic frontier. To our knowledge, a model of resistance to the combined three drugs has never been described due to the difficulty of modelling the FOLFIRINOX protocol both in vitro and in vivo. Patient‐derived tumour organoids (PDO) are the missing link that has long been lacking in the wide range of epithelial cancer models between 2D adherent cultures and in vivo xenografts. In this work we sought to set up a model of PDO with resistance to FOLFIRINOX regimen that we could compare to the paired naive PDO. Results: We first extrapolated physiological concentrations of the three drugs using previous pharmacodynamics studies and bi‐compartmental elimination models of oxaliplatin and SN‐38. We then treated PaTa‐1818x naive PDAC organoids with six cycles of 72 h‐FOLFIRINOX treatment followed by 96 h interruption. Thereafter, we systematically compared treated organoids to PaTa‐1818x naive organoids in terms of growth, proliferation, viability and expression of genes involved in cancer stemness and aggressiveness. Conclusions: We reproductively obtained resistant organoids FoxR that significantly showed less sensitivity to FOLFORINOX treatment than the PaTa‐1818x naive organoids from which they were derived. Our resistant model is representative of the sequential steps of chemoresistance observed in patients in terms of growth arrest (proliferation blockade), residual disease (cell quiescence/dormancy) and relapse. Significance: To our knowledge, this is the first genuine in vitro model of resistance to the three drugs in combined therapy. This new PDO model will be a great asset for the discovery of acquired chemoresistance mechanisms, knowledge that is mandatory before offering new therapeutic strategies for pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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47. CARMN‐NOTCH2 fusion transcript drives high NOTCH2 expression in glomus tumors of the upper digestive tract.

Author

Girard, Nicolas, Marin, Cristi, Hélias‐Rodzewicz, Zofia, Villa, Chiara, Julié, Catherine, de Lajarte‐Thirouard, Anne‐Sophie, de Beauce, Simon Martin, Lagorce‐Pages, Christine, Renaud, Florence, Cazals‐Hatem, Dominique, Guedj, Nathalie, Cros, Jérome, Raffin‐Sanson, Marie‐Laure, Selves, Janick, Terris, Benoit, Fléjou, Jean‐François, Garchon, Henri‐Jean, Coindre, Jean‐Michel, and Emile, Jean‐François

Published
2021
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48. Limited Resection Versus Pancreaticoduodenectomy for Duodenal Gastrointestinal Stromal Tumors? Enucleation Interferes in the Debate: A European Multicenter Retrospective Cohort Study.

Author

Dubois, Clément, Nuytens, Frederiek, Behal, Hélène, Gronnier, Caroline, Manceau, Gilles, Warlaumont, Maxime, Duhamel, Alain, Denost, Quentin, Honoré, Charles, Facy, Olivier, Tuech, Jean-Jacques, Tiberio, Guido, Brigand, Cécile, Bail, Jean-Pierre, Salame, Ephrem, Meunier, Bernard, Lefevre, Jérémie H., Mathonnet, Muriel, Idrissi, Mohamed Sbai, and Renaud, Florence

Abstract

Background: The optimal surgical procedure for duodenal gastrointestinal stromal tumors (D-GISTs) remains poorly defined. Pancreaticoduodenectomy (PD) allows for a wide resection but is associated with a high morbidity rate. Objectives: The aim of this study was to compare the short- and long-term outcomes of PD versus limited resection (LR) for D-GISTs and to evaluate the role of tumor enucleation (EN). Methods: In this retrospective European multicenter cohort study, 100 patients who underwent resection for D-GIST between 2001 and 2013 were compared between PD (n = 19) and LR (n = 81). LR included segmental duodenectomy (n = 47), wedge resection (n = 21), or EN (n = 13). The primary objective was to evaluate disease-free survival (DFS) between the groups, while the secondary objectives were to analyze the overall morbidity and mortality, radicality of resection, and 5-year overall survival (OS) and recurrence rates between groups. Furthermore, the short- and long-term outcomes of EN were evaluated. Results: Baseline characteristics were comparable between the PD and LR groups, except for a more frequent D2 tumor location in the PD group (68.3% vs. 29.6%; p = 0.016). Postoperative morbidity was higher after PD (68.4% vs. 23.5%; p < 0.001). OS (p = 0.70) and DFS (p = 0.64) were comparable after adjustment for D2 location and adjuvant therapy rate. EN was performed more in American Society of Anesthesiologists (ASA) stage III/IV patients with tumors < 5 cm and was associated with a 5-year OS rate of 84.6%, without any disease recurrences. Conclusions: For D-GISTs, LR should be the procedure of choice due to lower morbidity and similar oncological outcomes compared with PD. In selected patients, EN appears to be associated with equivalent short- and long-term outcomes. Based on these results, a surgical treatment algorithm is proposed. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Tubular aggregate myopathy and Stormorken syndrome: Mutation spectrum and genotype/phenotype correlation

Author

Morin, Gilles, primary, Biancalana, Valérie, additional, Echaniz‐Laguna, Andoni, additional, Noury, Jean‐Baptiste, additional, Lornage, Xavière, additional, Moggio, Maurizio, additional, Ripolone, Michela, additional, Violano, Raffaella, additional, Marcorelles, Pascale, additional, Maréchal, Denis, additional, Renaud, Florence, additional, Maurage, Claude‐Alain, additional, Tard, Céline, additional, Cuisset, Jean‐Marie, additional, Laporte, Jocelyn, additional, and Böhm, Johann, additional

Published
2019
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