415 results on '"Respiratory symptom"'
Search Results
2. The impact of tangeretin combined with whey protein on exercise-induced bronchoconstriction in professional athletes: a placebo-controlled trial
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Zhi Cao, Can Zhao, Shiwei Mo, Bing-Hong Gao, and Meng Liu
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Tangeretin ,exercise-induced bronchoconstriction ,airway inflammation ,lung function ,respiratory symptom ,VO2max ,Nutrition. Foods and food supply ,TX341-641 ,Sports medicine ,RC1200-1245 - Abstract
Background Exercise-induced bronchoconstriction (EIB) is highly prevalent in athletes. The objective of this study was to assess the therapeutic efficacy of daily tangeretin combined with whey protein supplementation over a period of 4 weeks in professional athletes with EIB.Methods Using a placebo-controlled, double-blind, paired, randomized trial design, a cohort of 30 professional athletes with EIB, consisting of 14 females and 16 males, was divided into two groups: the tangeretin combined with whey protein intervention group (TIG), and the placebo control group (PCG). Both the TIG and PCG underwent exercise challenge tests (ECT) and VO2max tests before (ECT1, V1) and after (ECT2, V2) the intervention. Blood (eosinophils, neutrophils, and basophils) and serum (interleukin-5, IL-5; interleukin-8, IL-8; Clara cell secretory protein-16, CC16; immunoglobulin E, IgE) levels were measured early in the morning of ECT1 and ECT2, respectively. Lung function was assessed immediately before and post-ECT immediately.Results Tangeretin combined with whey protein use for 4 weeks attenuated the decrease in forced expiratory volume in 1 s (FEV1) post trials (∆FEV1(ECT1-ECT2): mean (SD) TIG −7.51(6.9)% vs. PCG −2.33(11.49)%, p = 0.013). Tangeretin also substantially attenuated IL-5 concentration (∆IL-5(T1-T5): Tangeretin −19.4% vs Placebo + 8.37%, p = 0.022); IL-8 concentration (∆IL-8(T1-T5): Tangeretin −17.28% vs Placebo + 6.1%, p = 0.012); CC16 concentration (∆CC16(T1-T5): Tangeretin −11.77% vs Placebo + 24.19%); and IgE concentration in the serum (∆IgE(T1-T5): Tangeretin −24.1% vs Placebo −3.9%), and significantly decreased neutrophil count (∆N(T1-T5): Tangeretin −11.34% vs Placebo + 0.3%) and eosinophil count in blood (∆N(T1-T5): Tangeretin −38.5% vs Placebo + 4.35%). Compared with V1, VO2max (p = 0.042) and TLim (p = 0.05) of V2 were significantly increased in the TIG, and there was no significant change in the PCG. Meanwhile, six athletes in the TIG and 0 athletes in the PCG became EIB-negative at ECT2; the overall negative conversion rate of EIB was 40.00% in TCG. Additionally, the number of cough symptoms decreased from 9 to 3 and dyspnea from 4 to 2 in the TIG.Conclusion After high-intensity exercise, athletes with EIB achieved significant improvements in lung function and blood inflammatory factors by combining tangeretin and whey protein supplementation. EIB athletes also showed longer exercise endurance and VO2max at 4 weeks after TI. In addition, some patient symptoms disappeared after combination supplementation. The effect of this treatment on professional athletes with EIB was beneficial.
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- 2024
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3. Sex-specific characteristics for the coexistence of asthma and COPD in the Canadian population: a cross-sectional analysis of CLSA data.
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Veerasingam, Edwina, Gao, Zhiwei, Beach, Jeremy, and Senthilselvan, Ambikaipakan
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CANADIANS , *CHRONIC obstructive pulmonary disease , *CROSS-sectional method , *ASTHMA , *RESPIRATORY obstructions , *WHEEZE , *OSTEOPOROSIS - Abstract
Objective: The coexistence of asthma and COPD (asthma + COPD) is a condition found among patients who present with clinical features of both asthma and COPD. Epidemiological evidence points to an increasingly disproportionate burden of asthma + COPD and COPD in females. The objective of this cross-sectional study is to identify female and male-specific epidemiological and clinical characteristics associated with asthma + COPD. Methods: Baseline data from the comprehensive cohort of Canadian Longitudinal Study on Aging (CLSA) were used in this cross-sectional study which included 30,097 subjects between the ages of 45- and 85-years Participants were categorized into four mutually exclusive groups: asthma + COPD, COPD-only, asthma-only and neither asthma nor COPD. Results: The prevalence was significantly greater in females than males for asthma + COPD (2.71% vs. 1.41%; p < 0.001), COPD-only (3.22% vs. 2.87%; p < 0.001) and asthma-only (13.31% vs. 10.11%; p < 0.001). The association between smoking and asthma + COPD was modified by age in females. Osteoporosis and underactive thyroid disease were significantly more prevalent in females than in males in asthma + COPD, COPD-only and asthma-only groups. In asthma + COPD group, a greater proportion of respiratory symptoms associated with asthma was observed in females whereas a greater proportion of respiratory symptoms associated with COPD was observed in males. Severity of airway obstruction determined by spirometry measurements was greater in males than females. Conclusions: In the Canadian adult population, several epidemiological and clinical characteristics in asthma + COPD varied between females and males. The findings in this study will help healthcare professional in the recognition and management of coexisting asthma and COPD in females and males. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Grill workers and air pollution health effects from charcoal combustion in Vientiane capital
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Vanphanom Sychareun, Viengnakhone Vongxay, Kongmany Chaleunvong, Souksamone Thongmixay, Bounmany Soulideth, Diane Archer, Connie O’Neill, and Jo Durham
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Grill worker ,Air pollution ,Charcoal ,Particulate matter (PM) ,Respiratory symptom ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Introduction: Grilled street foods are popular in urban communities in Lao People's Democratic Republic (Lao PDR). Charcoal is the main fuel used for, posing a risk of elevated exposure to toxic pollutants. This study explored levels of cooking-related pollutants from grilled food business and workers’ health effects. Materials and methods: A quantitative approach using multiple techniques was conducted during March and April 2022 in Vientiane Capital, Lao PDR. Methods included pollutant emission estimation from charcoal-combusting grill shops/street-carts and Particulate Matter (PM2.5) measurement, and examined the exposure and health effects among grill workers. Multiple sampling techniques were applied to identify study samples. Respiratory symptoms were the health effect of interest among grill workers. Results: Estimated emission of pollutants was over 75 tons/year from grill shops. Average PM2.5 level was 84.8 μg/m3 (21.6 - 254.8 μg/m3); which is above standard limits. A very high level of PM2.5 was found in grill markets. Most grill workers were female, worked 6-7 days/week, at least 8 h/day. Factors contributing to the presence of respiratory symptoms among grill workers were female gender, low income, indoor grilling, more years of grill-work, experience of intense smoke-cough, self-reliance on health and cigarette smoking. Conclusion: Grilling contributes to ambient air pollution, posing potential adverse environmental and public health impacts. Grill workers are likely to be exposed to high levels of all forms of air pollutants from street food grilling. Effective strategies are required to better protect grill workers from the effect of exposure to these harmful toxins and minimize the negative impacts on their health.
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- 2023
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5. Grill workers and air pollution health effects from charcoal combustion in Vientiane capital.
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Sychareun, Vanphanom, Vongxay, Viengnakhone, Chaleunvong, Kongmany, Thongmixay, Souksamone, Soulideth, Bounmany, Archer, Diane, O'Neill, Connie, and Durham, Jo
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AIR pollution ,INDUSTRIAL hygiene ,CHARCOAL ,COMBUSTION ,PARTICULATE matter - Published
- 2023
6. The Relationship Between Potential Occupational Sensitizing Exposures and Asthma: An Overview of Systematic Reviews.
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Dalbøge, Annett, Kolstad, Henrik Albert, Ulrik, Charlotte Suppli, Sherson, David Lee, Meyer, Harald William, Ebbehøj, Niels, Sigsgaard, Torben, Zock, Jan-Paul, Baur, Xaver, and Schlünssen, Vivi
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ONLINE information services , *MEDICAL databases , *LABORATORY animals , *ASTHMA , *MEDICAL information storage & retrieval systems , *DUST , *SYSTEMATIC reviews , *HOUSE dust mites , *OCCUPATIONAL exposure , *RESEARCH funding , *MEDLINE , *INFORMATION storage & retrieval systems , *ASPERGILLUS - Abstract
Objectives The aim was to identify, appraise, and synthesize the scientific evidence of the relationship between potential occupational sensitizing exposures and the development of asthma based on systematic reviews. Methods The study was conducted as an overview of systematic reviews. A systematic literature search was conducted for systematic reviews published up to 9 February 2020. Eligibility study criteria included persons in or above the working age, potential occupational sensitizing exposures, and outcomes defined as asthma. Potential occupational sensitizing exposures were divided into 23 main groups comprising both subgroups and specific exposures. Two reviewers independently selected studies, extracted study data, assessed study quality, and evaluated confidence in study results and level of evidence of the relationship between potential occupational sensitizing exposures and asthma. Results Twenty-seven systematic reviews were included covering 1242 studies and 486 potential occupational sensitizing exposures. Overall confidence in study results was rated high in three systematic reviews, moderate in seven reviews, and low in 17 reviews. Strong evidence for the main group of wood dusts and moderate evidence for main groups of mites and fish was found. For subgroups/specific exposures, strong evidence was found for toluene diisocyanates, Aspergillus, Cladosporium , Penicillium, and work tasks involving exposure to laboratory animals, whereas moderate evidence was found for 52 subgroups/specific exposures. Conclusions This overview identified hundreds of potential occupational sensitizing exposures suspected to cause asthma and evaluated the level of evidence for each exposure. Strong evidence was found for wood dust in general and for toluene diisocyanates, Aspergillus, Cladosporium , Penicillium, and work tasks involving exposure to laboratory animals. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Development and Validation of a Respiratory-Responsive Vocal Biomarker–Based Tool for Generalizable Detection of Respiratory Impairment: Independent Case-Control Studies in Multiple Respiratory Conditions Including Asthma, Chronic Obstructive...
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Kaur, Savneet, Larsen, Erik, Harper, James, Purandare, Bharat, Uluer, Ahmet, Hasdianda, Mohammad Adrian, Umale, Nikita Arun, Killeen, James, Castillo, Edward, and Jariwala, Sunit
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CHRONIC obstructive pulmonary disease ,INTERSTITIAL lung diseases ,COVID-19 ,RESPIRATORY diseases ,ASYMPTOMATIC patients - Abstract
Background: Vocal biomarker–based machine learning approaches have shown promising results in the detection of various health conditions, including respiratory diseases, such as asthma. Objective: This study aimed to determine whether a respiratory-responsive vocal biomarker (RRVB) model platform initially trained on an asthma and healthy volunteer (HV) data set can differentiate patients with active COVID-19 infection from asymptomatic HVs by assessing its sensitivity, specificity, and odds ratio (OR). Methods: A logistic regression model using a weighted sum of voice acoustic features was previously trained and validated on a data set of approximately 1700 patients with a confirmed asthma diagnosis and a similar number of healthy controls. The same model has shown generalizability to patients with chronic obstructive pulmonary disease, interstitial lung disease, and cough. In this study, 497 participants (female: n=268, 53.9%; <65 years old: n=467, 94%; Marathi speakers: n=253, 50.9%; English speakers: n=223, 44.9%; Spanish speakers: n=25, 5%) were enrolled across 4 clinical sites in the United States and India and provided voice samples and symptom reports on their personal smartphones. The participants included patients who are symptomatic COVID-19 positive and negative as well as asymptomatic HVs. The RRVB model performance was assessed by comparing it with the clinical diagnosis of COVID-19 confirmed by reverse transcriptase–polymerase chain reaction. Results: The ability of the RRVB model to differentiate patients with respiratory conditions from healthy controls was previously demonstrated on validation data in asthma, chronic obstructive pulmonary disease, interstitial lung disease, and cough, with ORs of 4.3, 9.1, 3.1, and 3.9, respectively. The same RRVB model in this study in COVID-19 performed with a sensitivity of 73.2%, specificity of 62.9%, and OR of 4.64 (P <.001). Patients who experienced respiratory symptoms were detected more frequently than those who did not experience respiratory symptoms and completely asymptomatic patients (sensitivity: 78.4% vs 67.4% vs 68%, respectively). Conclusions: The RRVB model has shown good generalizability across respiratory conditions, geographies, and languages. Results using data set of patients with COVID-19 demonstrate its meaningful potential to serve as a prescreening tool for identifying individuals at risk for COVID-19 infection in combination with temperature and symptom reports. Although not a COVID-19 test, these results suggest that the RRVB model can encourage targeted testing. Moreover, the generalizability of this model for detecting respiratory symptoms across different linguistic and geographic contexts suggests a potential path for the development and validation of voice-based tools for broader disease surveillance and monitoring applications in the future. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Prevalence of Respiratory Symptoms and Risk Factors Among Street Sweepers in Gondar City Northwest, Ethiopia, 2021: A Cross-Sectional Study.
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Worede, Eshetu Abera, Brhan Alemaw, Helen, Feleke, Hailemariam, and Engdaw, Garedew Tadege
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Background: Street sweepers are exposed to a variety of risk factors such as dust, bioaerosols, and volatile organic matter, which are responsible for the development of various respiratory symptoms and lung function impairments. However, there is a limited data on the prevalence of respiratory symptoms and associated factors among street sweepers in Ethiopia, especially in the study area. Objective: This study aimed to assess the prevalence of respiratory symptoms and associated factors among street sweepers in Gondar town, northwest Ethiopia, in 2021. Methods: Using simple random sampling technique, a total of 391 workers were selected between August 10 and September 15, 2021. The data was entered and analyzed using the Epi Info Version 7 and Statistical Package for Social Science (SPSS) 22 software, respectively. Descriptive statistics, bivariable, and multivariable logistic regression model were used. P ⩽.05 and adjusted odds ratios (AOR) with 95% confidence interval (CI) were used to declare the statistical significance. Result: A total of 391 respondents, with a response rate of 99.2% participated. The prevalence of respiratory symptoms among street sweepers was 35.3% (95% CI: 30.2, 40.5). History of respiratory illness (AOR = 7.75, (95% CI: 3.45, 17.45), washing personal protective equipments (PPE) after use (AOR = 4.77; 95% CI: 2.02, 11.28), previous work in cement (AOR = 3.10, 95% CI: 1.32, 7.34), and flour factories (AOR = 2.13, 95% CI: 2.02, 4.43), and alcohol drinking (AOR = 3.77, 95% CI: 1.94, 7.29) were associated with respiratory symptom among street sweepers. Conclusion: The overall prevalence of respiratory symptoms among street sweepers was 35.3%. Previous respiratory illness, washing personal protective equipment after use, previous work in a cement and flour factory, and drinking alcohol were independently associated with respiratory symptoms. To reduce the respiratory symptoms among street sweeper, it is advisable implementing safe work practice measures and behavioral changes among workers. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Effects of occupational exposures on respiratory health in steel factory workers
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Sajjad Mozaffari, Behzad Heibati, Maritta S. Jaakkola, Taina K. Lajunen, Safa Kalteh, Hadi Alimoradi, Mahsa Nazari, Ali Karimi, and Jouni J. K. Jaakkola
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air quality ,pulmonary function (PF) ,respiratory symptom ,steel industry ,epidemiological ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe steel factory work environment contains various chemical exposures that can affect indoor air quality and have impact on respiratory health of the workers.AimsThe objective of this study was to assess potential effects of occupational exposures in steel factory workers in Iran on the respiratory symptoms, occurrence and the lung function levels.MethodThis was a cross-sectional study of 133 men working in a steel factory forming the exposed group and 133 male office workers forming the reference group from a steel company in Iran. The participants filled in a questionnaire and underwent spirometry. Work history was used both as dichotomous (exposed/reference) and a quantitative measure of exposure, the latter measured as duration of exposure in the specified work (in years) for the exposed group and zero for the reference group.ResultsMultiple linear regression and Poisson regression were used to adjust for confounding. In Poisson regression analyses, an increased prevalence ratio (PR) of all respiratory symptoms was observed in the exposed group. Lung function parameters were significantly reduced in the exposed group (p < 0.001). There was a dose–response relation between duration of occupational exposures and reduction in the predicted value of FEV1/FVC level (0.177, 95% CI −0.198 to −0.156) in all models.ConclusionThe results of these analyses showed that occupational exposures in steel factory work increase the prevalence of respiratory symptoms and reduce lung function. Safety training and workplace conditions were found to need improvement. In addition, use of proper personal protective equipment is recommended.
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- 2023
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10. Therapeutic Management of COVID-19 in a Pediatric Patient with Neurodegenerative CLN2 Disease and ICV—Enzyme Replacement Therapy: A Case Report.
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Schwering, Christoph, Apostolidou, Sofia, Deindl, Philipp, Christner, Martin, Knobloch, Johannes K.-M., Herrmann, Jochen, Kobbe, Robin, Schulz, Angela, Singer, Dominique, and Ebenebe, Chinedu Ulrich
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COVID-19 , *ENZYME replacement therapy , *CHILD patients , *CORONAVIRUS diseases , *NEURODEGENERATION - Abstract
The 12 years old male patient presented here suffers from neuronal ceroid lipofuscinoses 2 (CLN2) (MIM# 204500) and receives intracerebroventricular enzyme replacement therapy (ICV-ERT) every 14 days. After the emergence of the coronavirus disease 2019 (COVID-19) pandemic, routine care of children and adolescents with rare chronic diseases has become challenging. Although, in general, children do not develop severe COVID-19, when severe acute respiratory syndrome coronavirus 2 infection was detected by polymerase chain reaction-screening examination in our CLN2 patient before hospital admission for ICV-ERT, he was regarded to be at risk. Upon diagnosis, the patient developed respiratory deterioration symptoms and was admitted to our pediatric intensive care unit to receive oxygen, remdesivir, and steroids. As far as we know, this is the first CLN2 patient receiving intraventricular enzyme therapy with COVID-19 who required intensive care treatment and specific therapy. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
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Citarella, B, Kartsonaki, C, Ibanez-Prada, E, Goncalves, B, Baruch, J, Escher, M, Pritchard, M, Wei, J, Philippy, F, Dagens, A, Hall, M, Lee, J, Kutsogiannis, D, Wils, E, Fernandes, M, Tirupakuzhi Vijayaraghavan, B, Panda, P, Martin-Loeches, I, Ohshimo, S, Fatoni, A, Horby, P, Dunning, J, Rello, J, Merson, L, Rojek, A, Vaillant, M, Olliaro, P, Reyes, L, Moharam, S, Abdalasalam, S, Abdalhadi, A, Abdalla, N, Abdalla, W, Abdalrheem, A, Abdalsalam, A, Abdeewi, S, Abdelgaum, E, Abdelhalim, M, Abdelkabir, M, Abdelrahman, I, Abdukahil, S, Abdulbaqi, L, Abdulhamid, S, Abdulhamid, W, Abdulkadir, N, Abdulwahed, E, Abdunabi, R, Abe, R, Abel, L, Abodina, A, Abrous, A, Absil, L, Jabal, K, Salah, N, Abusalama, A, Abuzaid, T, Acharya, S, Acker, A, Adam, E, Adem, S, Ademnou, M, Adewhajah, F, Adriao, D, Afum-Adjei Awuah, A, Agbogbatey, M, Al Ageel, S, Ahmed, A, Ahmed, M, Ahmed, S, Alaraji, Z, Elhefnawy Enan, A, Ahmed Khalil, R, Ahmed Mohamed Abdelaziz, A, Ainscough, K, Airlangga, E, Aisa, T, Aisha, A, Aisha, B, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Akwani, C, Al Qasim, E, Alajeeli, A, Alali, A, Alalqam, R, Alameen, A, Al-Aquily, M, Albakry, K, Albatni, S, Alberti, A, Aldabbourosama, O, Al-dabbous, T, Aldhalia, A, Aldoukali, A, Alegesan, S, Alessi, M, Alex, B, Alexandre, K, Al-Fares, A, Alflite, A, Alfoudri, H, Alhadad, Q, Alhaddad, H, Mohamed Abdalla Alhasan, M, Alhouri, A, Alhouri, H, Ali, A, Ali, I, TagElser Mohammed Ali, M, Abbas, S, Abdelghafar, Y, Sheikh, N, Alidjnou, K, Aljadi, M, Aljamal, S, Alkahlout, M, Alkaseek, A, Alkhafajee, Q, Allavena, C, Allou, N, Almasri, L, Almjersah, A, Alqandouz, R, Alrfaea, W, Alrifaee, M, Alsaadi, R, Al-Saba'a, Y, Alshareea, E, Alshenawy, E, Altaf, A, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amer, A, Amira, N, Adusei, A, Amuasi, J, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ankrah, S, Ansart, S, Anthonidass, S, Antonelli, M, Antunes de Brito, C, Apriyana, A, Arabi, Y, Aragao, I, Arancibia, F, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Aryal, D, Asensio, A, Ashley, E, Ashraf, M, Ben Ashur, A, Asiedu-Bekoe, F, Asif, N, Asim, M, Assi, G, Assie, J, Asyraf, A, Atangana, F, Atia, A, Atif, M, Abdelrhman Abdallahrs, A, Atique, A, Atlowly, M, Attanyake, A, Auchabie, J, Aumaitre, H, Auvet, A, Ali Mohammed, A, Axelsen, E, Ayad, A, Hassan Helmi, A, Azemar, L, Azizeldin, M, Azoulay, C, Babatunde, H, Bach, B, Bachelet, D, Badr, C, Baevre-Jensen, R, Baig, N, Baillie, J, Baird, J, Bak, E, Bakakos, A, Bakar, N, Bakeer, H, Bakri, A, Bal, A, Balakrishnan, M, Bandoh, I, Bani-Sadr, F, Barbalho, R, Barbosa, N, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Bartoli, M, Basmaci, R, Basri, M, Batool, A, Battaglini, D, Bauer, J, Bautista Rincon, D, Dow, D, Beane, A, Bedossa, A, Bee, K, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beltrao, B, Beluze, M, Benech, N, Benjiman, L, Bennett, S, Bento, L, Berdal, J, Berdeweel, L, Bergeaud, D, Bergin, H, Bertoli, G, Bertolino, L, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianchi, I, Bianco, C, Bichoka, S, Bidin, F, Humaid, F, Bin Kamarudin, M, Binnawara, M, Bisoffi, Z, Biston, P, Bitker, L, Bittaye, M, Bitton, J, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Boccia, F, Bodenes, L, Bogaert, D, Boivin, A, Bolanga, A, Bolanos, I, Bolze, P, Bompart, F, Bonifasius, A, Bonney, J, Borges, D, Borie, R, Bosse, H, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Bountthasavong, L, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Boyer-Besseyre, M, Boylan, M, Bozza, F, Braconnier, A, Braga, C, Brandenburger, T, Monteiro, F, Brazzi, L, Breen, D, Breen, P, Brewster, D, Brickell, K, Broadley, T, Brotherton, H, Browne, A, Brozzi, N, Brunvoll, S, Brusse-Keizer, M, Bryda, P, Buchtele, N, Bugaeva, P, Buisson, M, Buonsenso, D, Burhan, E, Buri, D, Burrell, A, Bustos, I, Butnaru, D, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Garces, R, Calligy, K, Calvache, J, Camoes, J, Campana, V, Campbell, P, Campisi, J, Canepa, C, Cantero, M, Caoili, J, Caraux-Paz, P, Carcel, S, Cardoso, F, Cardoso, N, Cardoso, S, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M, Carrier, F, Carroll, I, Carson, G, Casanova, M, Cascao, M, Casey, S, Casimiro, J, Cassandra, B, Castaneda, S, Castanheira, N, Castor-Alexandre, G, Castro, I, Catarino, A, Catherine, F, Cattaneo, P, Cavalin, R, Cavalli, G, Cavayas, A, Ceccato, A, Ceesay, M, Cerkovnik, S, Cervantes-Gonzalez, M, Cevik, M, Chair, A, Chakveatze, C, Chan, A, Chand, M, Chapplain, J, Charpentier, C, Chas, J, Chaudry, M, Chavez Iniguez, J, Chen, A, Chen, Y, Chenard, L, Cheng, M, Cheret, A, Chiarabini, T, Chica, J, Chidambaram, S, Tho, L, Chirouze, C, Chiumello, D, Cho, S, Cholley, B, Chommanam, D, Chopin, M, Chow, Y, Chow, T, Christy, N, Chua, H, Chua, J, Cidade, J, Cisneros Herreros, J, Ciullo, A, Clarke, J, Claure-Del Granado, R, Clohisey, S, Codan, C, Cody, C, Coles, J, Coles, M, Colin, G, Collins, M, Combs, P, Connolly, J, Connor, M, Conrad, A, Conway, E, Cooke, G, Cordel, H, Corley, A, Cornelis, S, Cornet, A, Corpuz, A, Cortegiani, A, Corvaisier, G, Couffignal, C, Couffin-Cadiergues, S, Courtois, R, Cousse, S, Cowan, J, Cregan, R, Crowl, G, Crump, J, Cruz, C, Csete, M, Cullen, A, Cummings, M, Curley, G, Curlier, E, Curran, C, Custodio, P, da Silva Filipe, A, Da Silveira, C, Dabaliz, A, Dahl, J, Dahly, D, D'Alessandro, U, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Daly, S, Damas, J, Dame, J, Damien, C, Daneman, N, Dantas, J, D'Aragon, F, de Loughry, G, de Mendoza, D, De Montmollin, E, Franca, R, Isabel de Pinho Oliveira, A, De Rosa, R, De Rose, C, de Silva, T, de Vries, P, Deacon, J, Dean, D, Debard, A, Debenedictis, B, Debray, M, Decastro, N, Dechert, W, Decours, R, Defous, E, Delacroix, I, Delamou, A, Delaveuve, E, Delavigne, K, Delfos, N, Deligiannis, I, Dell'Amore, A, Delmas, C, Delobel, P, Delsing, C, Demonchy, E, Denis, E, Deplanque, D, Depuydt, P, Descamps, D, Desvallees, M, Dewayanti, S, Dhangar, P, Diallo, A, Diallo, S, Diamantis, S, Dias, A, Da Silva, F, Diaz, R, Diaz, J, Diaz, P, Dibba, B, Didier, K, Diehl, J, Dieperink, W, Dimet, J, Dinot, V, Diop, F, Diouf, A, Dishon, Y, Djadda, C, Djossou, F, Docherty, A, Doherty, H, Dondorp, A, Donnelly, C, Donohue, Y, Donohue, S, Doran, P, Dorival, C, D'Ortenzio, E, Doshi, Y, Douangdala, P, Douglas, J, Douma, R, Dournon, N, Downey, J, Downing, M, Drake, T, Driscoll, A, Duah, I, Fonseca, C, Dubee, V, Dubos, F, Dubot-Peres, A, Ducancelle, A, Duculan, T, Dudman, S, Duggal, A, Dunand, P, Duplaix, M, Durante-Mangoni, E, Durham, L, Dussol, B, Duthoit, J, Duval, X, Dyrhol-Riise, A, Ean, S, Ebo, A, Echeverria-Villalobos, M, Edelstein, M, Egan, S, Eggesbo, L, Ehzaz, K, Eira, C, El Sanharawi, M, El Sayed, M, Elabid, M, Elagili, M, Elapavaluru, S, Elbahnasawy, M, Elboshra, S, Elharrar, B, Ellerbroek, J, Ellingjord-Dale, M, 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J., Cortegiani A., Corvaisier G., Couffignal C., Couffin-Cadiergues S., Courtois R., Cousse S., Cowan J., Cregan R., Crowl G., Crump J., Cruz C., Csete M., Cullen A., Cummings M., Curley G., Curlier E., Curran C., Custodio P., da Silva Filipe A., Da Silveira C., Dabaliz A. -A., Dahl J. A., Dahly D., D'Alessandro U., Daley P., Dalloul Z., Dalton H., Dalton J., Daly S., Damas J., Dame J., Damien C., Daneman N., Dantas J., D'Aragon F., de Loughry G., de Mendoza D., De Montmollin E., Franca R. F. D. O., Isabel de Pinho Oliveira A., De Rosa R., De Rose C., de Silva T., de Vries P., Deacon J., Dean D., Debard A., DeBenedictis B., Debray M. -P., DeCastro N., Dechert W., Decours R., Defous E., Delacroix I., Delamou A., Delaveuve E., Delavigne K., Delfos N. M., Deligiannis I., Dell'Amore A., Delmas C., Delobel P., Delsing C., Demonchy E., Denis E., Deplanque D., Depuydt P., Descamps D., Desvallees M., Dewayanti S., Dhangar P., Diallo A., Diallo S. T., Diamantis S., Dias A., Da Silva F. D., Diaz R., Diaz J. J., Diaz P., Dibba B. K., Didier K., Diehl J. -L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Djadda C., Djossou F., Docherty A. B., Doherty H., Dondorp A. M., Donnelly C. A., Donohue Y., Donohue S., Doran P., Dorival C., D'Ortenzio E., Doshi Y., Douangdala P., Douglas J. J., Douma R., Dournon N., Downey J., Downing M., Drake T., Driscoll A., Duah I. K., Fonseca C. D., Dubee V., Dubos F., Dubot-Peres A., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Duplaix M., Durante-Mangoni E., Durham L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A. M., Ean S. C., Ebo A., Echeverria-Villalobos M., Edelstein M., Egan S., Eggesbo L. M., Ehzaz K., Eira C., El Sanharawi M., El Sayed M., Elabid M., Elagili M. B., Elapavaluru S., Elbahnasawy M., Elboshra S., Elharrar B., Ellerbroek J., Ellingjord-Dale M., ELMagrahi H., Elmubark M. M., Elotmani L., Eloundou L., Eloy P., Elshaikhy B., Elshazly T., Elsokni W., Eltayeb A. A., Elyazar I., Emad Z. K., Embarek H., Enderle I., Endo T., Eneli G., Eng C. C., Engelmann I., Enouf V., Epaulard O., Esaadi H., Esperatti M., Esperou H., Santo C. E., Esposito-Farese M., Essaka R., Essuman L., Estevao J., Etienne M., Everding A. G., Evers M., Fabre I., Fabre M., Fadera I., Abdalla Fadlalla A. O., Faheem A., Fahy A., Fairfield C. J., Fakar Z., Fareed K., Faria P., Farooq A., Fateena H., Fathi M., Fatima S., Faure K., Favory R., Fayed M., Feely N., Fernandes J., Fernandes S., Ferrand F. -X., Devouge E. F., Ferrao J., Ferraz M., Ferreira B., Ferreira I., Ferreira S., Ferriere N., Ficko C., Figueiredo-Mello C., Finlayson W., Flament T., Fletcher T., Florence A. -M., Florio L. L., Flynn B., Flynn D., Foley J., Fomin V., Fonseca T., Fontela P., Forrest K., Forsyth S., Foster D., Foti G., Fotso B., Fourn E., Fowler R. A., Fraher M., Franch-Llasat D., Fraser C., Fraser J. F., Freire M. V., Ribeiro A. F., French C., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Argin G., Gaborieau V., Gaci R., Gagliardi M., Gagnard J. -C., Gagneux-Brunon A., Gai A., Gaiao S., Skeie L. G., Galal Mohamed Ramadan A. M., Gallagher P., Gamble C., Gani Y., Garan A., Garcia R., Garcia-Diaz J., Garcia-Gallo E., Garimella N., Garot D., Garrait V., Gauli B., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Morlaes L. G., Germano N., Ghemmeid M., Ghisulal P. K., Ghosn J., Giani M., Gigante T., Gilroy E., Giordano G., Girvan M., Gissot V., Giwangkancana G., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J. -C., Goh J. Y., Golacs B., Golob J., Gomez K., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E. W., Granier P., Grasselli G., Grazioli L., Green C. A., Greene C., Greenhalf W., Greffe S., Grieco D. L., Griffee M., Griffiths F., Grigoras I., Groenendijk A., Grovogui F. M., Gruner H., Gu Y., Guedj J., Guego M., Guerguerian A. -M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., Guimaraes de Castro M., Guimard T., Haalboom M., Haber D., Hachemi A., Haddud A., Hadri N., Hafez W., Haidri F. R., Rida Hajij F. M., Hakak S., Hall A., Halpin S., Hamdan S., Hamdi A., Hameed J., Hamer A., Hamers R. L., Hamidfar R., Hammarstrom B., Hammond N., Hammond T., Han L. Y., Hanan M., Haniffa R., Hao K. W., Hardwick H., Harrison E. M., Harrison J., Ekow Harrison S. B., Hartman A., Hasan S., Nabil Hasan M. A., Hasan M. S., Hashmi J., Hashmi M., Hassan A., Hassanin E., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Helmi A., Hendry R., Hennessy M., Henriquez-Trujillo A. R., Hentzien M., Hernandez D., Hershey A., Hesstvedt L., Hidayah A., Higgins E., Higgins R., Hinton S., Hiraiwa H., Hirkani H., Hitoto H., Ho A., Ho Y. B., Hoctin A., Hoffmann I., Hoh W. H., Hoiting O., Holt R., Holter J. C., Horcajada J. P., Houas I., Houderi M., Hough C. L., Houltham S., Ming-Yang Hsu J., Hulot J. -S., Hurd A., Hussain I., Hussein A. M., Hussein M., Ibrahim F., Ibran B., Ijaz S., Ikram M. A., Illana C. C., Imbert P., Ansari M. I., Sikander R. I., Inacio H., Dominguez C. I., Ing Y. S., Ippolito M., Irawany V., Isgett S., Isidoro T., Ismail N., Isnard M., Istre M. S., Itai J., Ivulich D., Jaafar D., Jaafoura S., Jaber H., Jabot J., Jackson C., Jagne A., Jaureguiberry S., Jaworsky D., Jego F., Jelani A. M., Jenum S., Jimbo-Sotomayor R., Joe O. Y., Jorge Garcia R. N., Jorgensen S. B., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., Jung A., Jung H., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kalleberg K. T., Kalomoiri S., Ayadi Kamaluddin M. A., Kamano A. S., Che Kamaruddin Z. A., Kamarudin N., Kamineni K., Kandamby D. H., Kang K. Y., Kanwal D., Kanyawati D., Karghul M., Karpayah P., Karsies T., Kasugai D., Katz K., Kay C., Kayyali L., Keating S., Kedia P., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennon K., Keomany S., Kernan M., Kerroumi Y., Keshav S., Khail S., Khaled S., Khalid I., Khalil A., Khan I., Khan Q. A., Khanal S., Khatak A., Kherajani K., Kho M. E., Khoo D., Khoo R., Khoo S., Khoso M. N., Khuwaja A., Kiat K. H., Kida Y., Kiiza P., Granerud B. K., Kildal A. B., Kim J. B., Kimmoun A., Kindgen-Milles D., Kitamura N., Kjetland Kjetland E. F., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Forson P. K., Kodippily C., Vasconcelos M. K., Koirala S., Komatsu M., Abebrese F. K., Korten V., Kouba S., Kourouma M. L., Kourouma K., Kpangon A., Krawczyk K., Kredan A., Krishnan V., Krishnan S., Kruglova O., Krund A., Kuan P. X., Kumar A., Kumar D., Kumar G., Kumar M., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Bedu-Addo A. K., Kwedi S., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lafhej N., Lagrange M., Laine F., Lairez O., Lakhey S., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Lath S., Latif N., Latifeh Y., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Leal E., Santos M. L., Lee B. H., Lee H. G., Lee S. H., Lee T. C., Lee Y. L., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lehiste M. -H., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H. S., Lennon J., Leon R., Leone M., Lepik T., Lepiller Q., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Letizia A., Letrou S., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Bassi G. L., Liang J., Liaquat A., Liegeon G., Lim K. C., Lim W. S., Lima C., Lina B., Lina L., Lind A., Lingad M. K., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Lee Low L., Lowik M., Loy J. S., Lucet J. C., Luna C. M., Lungu O., Lunn M., Luong L., Luque N., Luton D., Maasikas O., Machado M., Machado S., Macheda G., Magzoub M., Mahieu R., Mahy S., Maia A. R., Maier L. S., Ascofare O. M., Maillet M., Maitre T., Majeed N. A., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Maraczi V., Sant'Ana Malaque C. M., Marino F., Markowicz S., Marques A., Marquis C., Marsh L., Marsh B., Marshal M., Marshall J., Martelli C. T., Martin D. -A., Martin E., Martin-Blondel G., Martinelli A., Martinez F. E., Martinot M., Martin-Quiros A., Martins A., Martins J., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Mason S., Masood S., Masoud F., Massoma M., Masumbe P., Mat Nor M. B., Matan M., Fernandes H. M., Mathew M., Mathew C., Mattei M., Maulin L., May J., Maynar J., Mayxay M., Mazzoni T., Sweeney L. M., McArthur C., McCann N., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEvoy N., McGeer A., McLean K. A., McNally P., McNicholas B., Meaney E., Mear-Passard C., Mechlin M., Medombou N., Mehkri O., Mele F., Melo L., Memon K. A., Mendes J. J., Menkiti O., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Meta R., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Abdullah D. M., Miller J., Miranda-Maldonado H., Misnan N. A., Eliza Mohamed N. N., Mohamed N., Mohamed T. J., Ads A. M., Mohamed Elsayed Abdelhalim A. R., Mohammed L., Mohammed Mostafa S. F., Abdelrahman Mohammedahmed M. O., Mohammedelhassan O. A., Moin A., Mokhtar W., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Morgom M., Moro L., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mualla S. H., Muftah M., Mufti A. K., Muh N. Y., Muhaisen M., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Ali S. M., Munir N., Munshi L., Murphy A., Murray P., Murris M., Murthy S., Musaab H., Mustafa A., Mustafa M., Mustafa D., Muvindi H., Myrodia D. M., Mohd-Hanafiah F. N., Nadjm B., Nagpal D., Nagrebetsky A., Nagybanyai-Nagy B., Boudoin H. N., Narasimhan M., Narayanan N., Nasa P., Khan R. N., Nasrallah A., Nassif Metri A. G., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N., Nelder M., Nelwan E., Neto R., Neumann E., Ng W. Y., Ng P. Y., Nghi A., Nguyen D., Choileain O. N., Leathlobhair N. N., Niba N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Izzati Norharizam N. F., North A., Notari A., Noursadeghi M., Nowinski A., Nseir S., Numfor L., Nurnaningsih N., Nusantara D. U., Nyamankolly E., Nygaard A. B., Brien F. O., Callaghan A. O., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ofori-Boadu L., Ogston T., Ogura T., Oh T. -H., O'Halloran S., O'Hearn K., Ohene S. -A., Oliveira J., Oliveira L., Olliaro P. L., Rageh Elnaggar C. O., Mohammed Omer A. A., Ondobo P., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Ortoleva J., Elsayed Soliman M. O., Osatnik J., O'Shea L., O'Sullivan M., Othman E., Othman S. Z., Ouamara N., Ouissa R., Owusu M., Owusu-Asare A. A., Oziol E., Pagadoy M., Pages J., Palacios A., Palmarini M., Panarello G., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Pasquier J., Pastene B., Patauner F., Patel D., Pathmanathan M. D., Patrao L., Patricio P., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peake S. L., Peariasamy K., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrovic M., Petrov-Sanchez V., Pettersen F. O., Peytavin G., Philips R. O., Phonemixay O., Phoutthavong S., Piagnerelli M., Picard W., Picone O., de Piero M., Piersma D., Pimentel C., Pinto R., Pires C., Piroth L., Pitaloka A., Piubelli C., Pius R., Piva S., Plantier L., Png H. S., Poissy J., Pokeerbux R., Poli S., Pollakis G., Ponscarme D., Porto D. B., Post A. -M., Postma D. F., Povoa P., Povoas D., Powis J., Prapa S., Praphasiri V., Preau S., Prebensen C., Preiser J. -C., Prinssen A., Dilanthi Priyadarshani G. D., Proenca L., Pudota S., Semedi B. P., Pulicken M., Puplampu P., Purcell G., Quesada L., Quinones-Cardona V., Quist-Paulsen E., Quraishi M., Qutishat F., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragab A., Rahardjani M., Ullah A. R., Haji Ab Rahman A. K., Rahman R. A., Rainieri F., Rajahram G. S., Ramachandran P., Ramakrishnan N., Ramalho J., Ramli A. A., Rammaert B., Ramos G. V., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehman A., Rehman Khalid M. O., Reikvam D. H., Reis R., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Ribeiro M. I., Ricchiuto A., Richardson D., Richier L., Atikah Ahmad Ridzuan S. N., Rios A. L., Rishu A., Rispal P., Risso K., Rivera Nunez M. A., Robba C., Roberto A., Roberts S., Roberts C., Robertson D. L., Robineau O., Roca A., Roche-Campo F., Rodari P., Rodeia S., Roessler B., Roger C., Roger P. -M., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol P., Roy C., Roze B., Rusmawatiningtyas D., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadaf S., Sadat M., Sahraei V., Said A., Saidani N., Sakiyalak P., Sako F. B., Salah M., Salah Eldin Mohamed Abbas A. A., Salahuddin N., Salazar L., Saleem J., Alyasiri M. S., Abu Salem T. A., Sales G., Gandonniere C. S., Salvator H., Samardali D., Samardali S., Shaaban Aly Orabi Y. S., Sanchez E., Sanchez O., Sanchez de Oliveira K., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. S., Sarmiento I. C. E., Sarton B., Satya A., Satyapriya S., Satyawati R., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schnur J., Schroll S., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvanayagam J., Selvarajoo M., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Shadowitz E., Shahidan S. A., Shahla H., Shalabi L., Shames H., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Mohan Shetty D. R., Shetty R., Shiekh M., Shime N., Shimizu K., Shrapnel S., Shrestha S. K., Shrestha P. S., Shum H. P., Mohammed N. S., Siang N. Y., Siaw-Frimpong M., Sibiude J., Sibounheuang B., Siddig N., Siddiqui A., Siddiqui M. A., Sigfrid L., Sillah F., Sillaots P., Silva C., Silva M. J., Silva R., Lim Heng B. S., Sin W. C., Sinatti D., Singh M., Singh P., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Snacken M., So D., Soh T. V., Solberg L. B., Solomon J., Solomon T., Somers E., Sommet A., Song M. J., Song R., Song T., Chia J. S., Soraas A., Sotto A., Soum E., Sousa A. C., Sousa M., Uva M. S., Souza-Dantas V., Sow M. S., Sperry A., Spinuzza E., Ruwan Sri Darshana B. P. S., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Strong G., Stuart A., Stuart D., Su R., Subekti D., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Suwarti A., Svistunov A., Syahrin S., Sylverken A., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talla C., Talsma J., Tamisier R., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Taqdees H., Taqi A., Tardivon C., Kamal Mostafa Y. T., Tarhabat A., Tattevin P., Taufik M. A., Tawfik H., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Mohd Thabit A. A., Thakur A., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson N., Thompson S., Thomson E. C., Thomson D., Thorpe M., Thurai S. R. T., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Yang Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torre M., Torres A., Torres M., Santos-Olmo R. M. T., Torres-Zevallos H., Tounkara A., Towers M., Traore F. A., Trapani T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turgeon A. F., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. I., Udy A., Ullrich R., Uribe A., Usman A., Usuf E., Uyeki T. M., Vajdovics C., Valentini P., Val-Flores L., Van de Velde S., van den Berge M., van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varrone M., Vasudayan S. R., Vauchy C., Vecham P. K., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Vijayan D., Villar J., Villeneuve P. -M., Villoldo A., Vishwanathan G., Visseaux B., Visser H., Vitiello C., Vongsouvath M., Vonkeman H., Vuotto F., Wahab S. A., Wahab N. H., Wahid N. A., Wainstein M., Walsh L., Shukeri W. F. W. M., Wang C. -H., Webb S., Weil K., Wen T. P., Wesam H., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams P. J., Williams V., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Wright N., Xian L. S., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Hing N. Y. L., Mahmoud Abdelaal A. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yiaye T., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zabert G. E., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.
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- 2024
12. Is there still a social gradient in respiratory symptoms? A population-based nordic EpiLung-study
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Andersén, Heidi, Bhatta, Laxmi, Bashir, Muwada, Nwaru, Bright, Langhammer, Arnulf, Krokstad, Steinar, Piirilä, Päivi, Hisinger-Mölkänen, Hanna, Backman, Helena, Kankaanranta, Hannu, Hedman, Linnea, Andersén, Heidi, Bhatta, Laxmi, Bashir, Muwada, Nwaru, Bright, Langhammer, Arnulf, Krokstad, Steinar, Piirilä, Päivi, Hisinger-Mölkänen, Hanna, Backman, Helena, Kankaanranta, Hannu, and Hedman, Linnea
- Abstract
Background: Respiratory symptoms are a common public health issue that can partly be attributed to preventable risk factors, such as tobacco smoking and occupational exposure, which are more common in individuals with lower socioeconomic status. Objective: Our aim was to evaluate the social gradient in respiratory symptoms in Nordic countries. Methods: This study included participants aged 30–65 years from five cross-sectional population-based questionnaire surveys in 2016 in Finland and Sweden (N = 25,423) and in 2017–2019 in Norway (N = 27,107). Occupational skill levels 1 and 2 (occupations requiring compulsory education) were combined and compared to skill levels 3 and 4 (occupations requiring upper secondary and tertiary education). Meta-analysis was conducted to obtain pooled age- and sex adjusted odds ratios (aORs) of associations between occupational skill and the respiratory symptoms including recurrent wheeze, dyspnoea, and productive cough. Results: In the meta-analysis, recurrent wheeze, dyspnoea, and productive cough showed a social gradient. The participants with occupational skill 1 and 2 had higher risk for recurrent wheeze (aOR 1.78, 95% CI 1.34–2.22) and dyspnoea (aOR 1.59, 95% CI 1.29–1.90) compared to occupational skill 3 and 4 in Sweden and Finland. Similarly increased risk was observed for combined assessment of dyspnoea and wheeze (aOR 1.05, 95% CI 1.03–1.07) in Norway. In a meta-analysis including all three countries, the aOR for productive cough was 1.31 95% CI 1.07–1.56. Conclusions: Occupations with lower, compared to higher, skill levels were associated with an increased risk of recurrent wheeze, dyspnoea, and productive cough.
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- 2024
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13. Gastroesophageal reflux and snoring are related to asthma and respiratory symptoms : Results from a Nordic longitudinal population survey.
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Mir Fakhraei, Rima, Lindberg, Eva, Benediktsdóttir, Bryndís, Svanes, Cecilie, Johannessen, Ane, Holm, Mathias, Modig, Lars, Franklin, Karl A, Malinovschi, Andrei, Gislason, Thorarinn, Jögi, Rain, Cramer, Christine, Janson, Christer, Emilsson, Össur Ingi, Mir Fakhraei, Rima, Lindberg, Eva, Benediktsdóttir, Bryndís, Svanes, Cecilie, Johannessen, Ane, Holm, Mathias, Modig, Lars, Franklin, Karl A, Malinovschi, Andrei, Gislason, Thorarinn, Jögi, Rain, Cramer, Christine, Janson, Christer, and Emilsson, Össur Ingi
- Abstract
AIM: To study if individuals with nocturnal gastroesophageal reflux (nGER) and habitual snoring are more likely to develop asthma and respiratory symptoms (i.e. wheeze, cough, chest tightness, breathlessness) than those without these conditions, and if these associations are additive. METHODS: We used data from the population-based prospective questionnaire study Respiratory Health in Northern Europe (RHINE) (11,024 participants), with data from 1999 and 2011. Participants with heartburn or belching after going to bed, at least 1 night/week, were considered to have nGER. Participants reporting loud snoring at least 3 nights/week were considered to have habitual snoring. Participants were grouped into four groups by their nGER and snoring status: "never"; "former"; "incident"; "persistent". Incident respiratory symptoms were analyzed among participants without respective symptom at baseline. RESULTS: Snoring and nGER were independently associated with incident asthma and respiratory symptoms. The risk of incident wheeze was increased in subjects with incident or persistent snoring (adjusted odds ratio (95 % CI): 1.44 (1.21-1.72)), nGER (2.18 (1.60-2.98)) and in those with both snoring and nGER (2.59 (1.83-3.65)). The risk of developing asthma was increased in subjects with incident or persistent snoring (1.44 (1.15-1.82)), nGER (1.99 (1.35-2.93)) and in those with both snoring and nGER (1.72 (1.06-2.77)). No significant interaction was found between snoring and nGER. A similar pattern was found for the incidence of all other respiratory symptoms studied, with the highest risk among those with both incident or persistent nGER and snoring. CONCLUSION: The risk of developing asthma and respiratory symptoms is increased among subjects with nGER and habitual snoring. These associations are independent of each other and confounding factors. Snoring and nGER together are additive on respiratory symptoms.
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- 2024
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14. Respiratory health effects of the fiberglass-reinforced plastic lamination process in the yacht-building industry
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Chi-Hsien Chen, Perng-Jy Tsai, Ya-Fen Wang, Chih-Hong Pan, Po-Chen Hung, Jiune-Jye Ho, Diahn-Warng Perng, Benoit Nemery, and Yue Leon Guo
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respiratory health ,respiratory health effect ,fiberglass ,fiberglass-reinforced plastic lamination ,lamination ,yacht ,yacht-building industry ,laminator ,laminating process ,induced sputum ,lung function ,health effect ,respiratory symptom ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVES: Fiberglass-reinforced plastics (FRP) manufacturing has been related to cases of severe airway obstruction and elevated risk of respiratory mortality. But the specific job content risk is not clear. This study evaluated the respiratory health effects of the FRP lamination process. METHODS: A questionnaire was used to evaluate respiratory symptoms of workers in two yacht-building plants. Pre-shift (07:30–08:30 hours) and post-shift (17:00–18:00 hours) lung function was measured, while post-shift induced sputum was collected on the first day of the week. The participants were grouped into FRP laminators and non-laminators. Linear and logistic regression was used to investigate the effects of the lamination process on lung function. RESULTS: Laminators had a higher prevalence of chronic cough, lower pre-shift forced expiratory volume in first second (FEV1) and FEV1/force vital capacity (FVC) (-3.3% and -1.5%), lower post-shift FVC and FEV1 (-3.6% and -4.9%), and larger post-shift reduction of FVC (-2.1%) compared to non-laminators. The laminators also had higher risk of early obstructive and overall (obstructive plus restrictive) lung function impairment, and post-shift reduction of FVC >10% [odds ratio (OR) 5.98, 4.98, and 3.87, respectively). They also had higher percentages of neutrophils and lymphocytes in the induced sputum. CONCLUSION: Laminators should undergo regular check-ups of respiratory symptoms and lung function. Further toxicologic studies are warranted to identify the specific causal agent in the FRP lamination process.
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- 2021
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15. Indoor Air Quality and Respiratory Health Implication Among Malay Preschool Children in Puchong and Hulu Langat Selangor, Malaysia.
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Onwusereaka, Cynthia Oluchi, Jalaludin, Juliana, and Hisamuddin, Nur Hazirah
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- *
PRESCHOOL children , *INDOOR air quality , *AIR pollutants , *PULMONARY function tests , *MALAYS (Asian people) - Abstract
Introduction: Indoor air pollutant has caused a greater impact on the health of occupants' especially preschool age who are still growing. Objective: To determine the association between indoor air pollutants (Particulate Matter (PM2.5, PM10), Volatile Organic Compounds (VOCs), mould) and respiratory implications among preschool children in Selangor. Methods: A cross-sectional comparative study was conducted on 270 preschool children in Puchong (study area) and Hulu Langat (comparative area). Respiratory symptoms were assessed using a questionnaire adapted from the American Thoracic Society (ATS). DustTrak Aerosol monitor was used to assess PM2.5 and PM10; PbbRAE for measuring VOCs; Q-Trak Monitor for temperature and relative humidity; VelociCalc for air velocity; Pbi DuoSAS Super 360 for mould; Chestgraph HI-101 spirometer for lung function test (Forced Expiratory Volume in 1 second/ Forced Vital Capacity (FEV1/FVC%) and FEV1%. Results: Indoor PM2.5, PM10 and mould in the study area was significantly higher (p=0.001). There was a significant difference in FEV1/FVC%, and FEV1% predicted in the study and comparative group (p<0.05). There was a significant association between PM2.5 and PM10 with cough (p<0.005). Indoor PM10 and VOCs were significantly associated with FVC% (p<0.05). VOCs was significantly associated with FEV1% (p<0.001). Logistics regression analysis showed that the risk of FEV1% abnormality increased significantly with increase in PM10 (OR=2.1, 95% CI=2.509-8.221), VOCs (OR=5.3, 95% CI=1.912-14.835) and RH (OR=14.3, 95% CI= 1.451-14.306). Conclusion: High exposure to indoor air pollutants increases respiratory symptoms and reduce lung function among children. The moisture-damaged building materials need to be replaced to avoid mould growth. [ABSTRACT FROM AUTHOR]
- Published
- 2022
16. Health Risks Associated with Adopting New-Generation Disposable Products Among Young Adults Who Use E-Cigarettes.
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Ran S, Yang JJ, Piper ME, Lin HC, and Buu A
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- Humans, Male, Young Adult, Female, Adolescent, Adult, United States, Universities, Vaping adverse effects, Surveys and Questionnaires, Electronic Nicotine Delivery Systems
- Abstract
New-generation disposable e-cigarettes have become increasingly popular among young adults in the USA since the FDA's partial flavor ban. This study aims to examine longitudinal changes in health risks among young adults who adopted these novel products, as well as the health effects of device types beyond the effects of other important e-cigarette characteristics. This study recruited e-cigarette users via voluntary response sampling from three college campuses in the USA to respond to four-wave online surveys conducted in four consecutive semesters. Among the participants who adopted disposables during the study, their health risks (dependence symptoms, respiratory symptoms, combustible tobacco use) and e-cigarette consumption characteristics (use frequency, nicotine concentration and flavors) before and after the adoption were compared using paired-sample t- or McNemar's tests. Generalized linear mixed models with a random intercept were conducted on data from the entire sample to investigate the effects of device type (tank, cartridge/pod, disposable) on health risks, controlling for other e-cigarette consumption characteristics. The study sample of 650 e-cigarette users were, on average, 20 years old, with 49% being male, 70% being White, and 13% being Hispanic. Adopting disposables may increase secondary dependence motives (t = 2.42, p < 0.05) and the use of higher levels of nicotine concentration (t = 2.09, p < 0.05) and sweet flavors (x
2 = 22.53, p < 0.05) but decrease the number of times of vaping per day (t = -2.18, p < 0.05) and the use of menthol flavors (x2 = 4.57, p < 0.05). Tank use is associated with a higher level of primary dependence motives (b = 0.1998, p < 0.05) and a greater odds of using combustible tobacco (b = 0.4772, p < 0.05). Although disposable use is not associated with the likelihood of using combustible tobacco, it is associated with higher levels of both primary (b = 0.2158, p < 0.05) and secondary (b = 0.2533, p < 0.05) dependence motives. It is not the device type, but rather the frequency of vaping, that affects respiratory symptoms (b = 0.0602, p < 0.05). The findings indicate that when young adults switch to disposables, their e-cigarette dependence and use of sweet-flavored e-liquids increase. Even after controlling for use frequency, nicotine concentration and flavors, using disposables is related to not only instrumental motives that are influenced by psychological and environmental contexts but also heavy, automatic use that can operate without environmental cues. Given the health risks associated with disposable e-cigarettes, more comprehensive tobacco product regulations that consider the impact of device types may be needed.- Published
- 2024
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17. Granulomatous pneumonia in a cow infected with Toxoplasma gondii.
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Inoue, Ken, Takashima, Yasuhiro, Hirano, Shinji, and Kimura, Kumiko
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- *
TOXOPLASMA gondii , *COWS , *BEEF cattle , *NUCLEOTIDE sequencing , *PNEUMONIA , *LUNG infections - Abstract
We report a confirmed case of Toxoplasma gondii infection in the lungs of a cow exhibiting respiratory symptoms. At slaughter, white nodules were discovered in lung tissue, accompanied by enlarged hilar lymph nodes. Histological examination revealed the disappearance of alveolar structures in nodular areas, replaced by granulomas containing inflammatory cells. Immunohistochemical staining with anti- T. gondii antibody and nucleotide sequencing of 18S rDNA confirmed T. gondii infection. However, the link between T. gondii and observed symptoms remains unclear. Various factors, including host genetics, underlying diseases, infection route, and exposure level, may contribute to these uncommon symptoms. Although T. gondii infections in cattle are traditionally considered asymptomatic, our study suggests the possible existence of clinical symptoms associated with Toxoplasma infection. Beef cattle are generally not assumed to be a relevant source of human T. gondii infection; however, sporadic transmission by infected edible beef to humans cannot be completely excluded and deserves further studies. [Display omitted] • T. gondii infection in the lungs of a cow exhibiting respiratory symptoms. • Histopathological and molecular biological methods confirmed T. gondii infection. • This case suggests the existence of clinical symptoms associated with Toxoplasma. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Respiratory Symptoms in Post-infancy Children. A Dutch Pediatric Cohort Study
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Esther de Vries and Roeland W. N. M. van Hout
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child ,respiratory symptom ,season ,age ,cohort ,general population ,Pediatrics ,RJ1-570 - Abstract
Aim: To study the pattern of respiratory symptoms in children in the general population.Method: We followed a cohort of children for up to 2 years through parents completing weekly online questionnaires in the Child-Is-Ill study (“Kind-en-Ziekmeting” in Dutch); the study was running 2012–2015. Inclusion criteria were “an ordinary child” (according to the parents) and
- Published
- 2020
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19. Prevalence and Factors Associated with Respiratory Symptoms Among Bahir Dar Textile Industry Workers, Amhara Region, Ethiopia.
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Kifle, Manay, Gebremariam, Brhane, Alemu, Kasahun, and Woldeyohannes, Solomon Meseret
- Abstract
Introduction: The expansions of labor-intensive investments in a developing countries, especially in textile production create a dusty work environment for workers, and those workers are from the low socio-economic group and need special safety concern. Objective: This study was aimed at assessing the prevalence of respiratory symptoms and associated factors among textile factories workers in Bahir Dar, Amhara region, Ethiopia, 2015. Methods: Institutional based cross-sectional study design was employed among randomly selected 384 textile workers using pre-tested interviewer-administered questionnaire. We stratified workers by their working section in the textile industries. Then the proportional numbers of workers were selected from each working section of the factory by using a random number generator. The identification number of workers from each factory was used for selection. The data were checked, coded, and entered to Epi-info Version 7 and exported to the Statistical Package for Social Science Version 20 for further analysis. Both bivariate and multivariate logistic regressions were used to identify associated factors. Variables having a P ⩽.2 were fitted to multivariate logistic regression so as to assess the presence and strength of association with the respiratory symptom. Variables having a P <.05 were considered as significant. Results: Three hundred eighty-three (99.74%) of the study participants responded completely filling the questionnaire. In this study, the prevalence of cough, phlegm, bronchitis, chronic bronchitis, and chest pain among the respondents were 31 (8.1%), 45 (11.7%), 26 (6.8%), 2 (0.5%), and 21 (5.5%), respectively. Generally, 141 (36.81%) of the respondents have either of the above respiratory symptoms in the textile industry. Working in the spinning section (AOR = 3.26, 95% CI: 1.80, 5.89), being in the grade 11 and 12 level and below (AOR = 2.36, 95% CI: 1.50, 3.70) and personal protective equipment (PPE) utilization (AOR = 4.88 95% CI: 1.54-15.45) were significantly associated with respiratory symptoms in the multivariate analysis. Conclusion: The prevalence of respiratory symptoms in Bahir Dar Textile workers was relatively high. Working department, educational status, and PPE use were variables significantly associated with respiratory symptoms in this study. Experience sharing across departments, employing educated workers and provision of personal protective equipment are important tasks to be followed to reduce respiratory symptoms in the industry. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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20. Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease
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Hamakawa, Yoko and Hamakawa, Yoko
- Published
- 2023
21. Effects of occupational exposures on respiratory health in steel factory workers
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Mozaffari, S. (Sajjad), Heibati, B. (Behzad), Jaakkola, M. S. (Maritta S.), Lajunen, T. K. (Taina K.), Kalteh, S. (Safa), Alimoradi, H. (Hadi), Nazari, M. (Mahsa), Karimi, A. (Ali), Jaakkola, J. J. (Jouni J. K.), Mozaffari, S. (Sajjad), Heibati, B. (Behzad), Jaakkola, M. S. (Maritta S.), Lajunen, T. K. (Taina K.), Kalteh, S. (Safa), Alimoradi, H. (Hadi), Nazari, M. (Mahsa), Karimi, A. (Ali), and Jaakkola, J. J. (Jouni J. K.)
- Abstract
Background: The steel factory work environment contains various chemical exposures that can affect indoor air quality and have impact on respiratory health of the workers. Aims: The objective of this study was to assess potential effects of occupational exposures in steel factory workers in Iran on the respiratory symptoms, occurrence and the lung function levels. Method: This was a cross-sectional study of 133 men working in a steel factory forming the exposed group and 133 male office workers forming the reference group from a steel company in Iran. The participants filled in a questionnaire and underwent spirometry. Work history was used both as dichotomous (exposed/reference) and a quantitative measure of exposure, the latter measured as duration of exposure in the specified work (in years) for the exposed group and zero for the reference group. Results: Multiple linear regression and Poisson regression were used to adjust for confounding. In Poisson regression analyses, an increased prevalence ratio (PR) of all respiratory symptoms was observed in the exposed group. Lung function parameters were significantly reduced in the exposed group (p < 0.001). There was a dose–response relation between duration of occupational exposures and reduction in the predicted value of FEV1/FVC level (0.177, 95% CI −0.198 to −0.156) in all models. Conclusion: The results of these analyses showed that occupational exposures in steel factory work increase the prevalence of respiratory symptoms and reduce lung function. Safety training and workplace conditions were found to need improvement. In addition, use of proper personal protective equipment is recommended.
- Published
- 2023
22. The Relationship Between Potential Occupational Sensitizing Exposures and Asthma:An Overview of Systematic Reviews
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Dalbøge, Annett, Albert Kolstad, Henrik, Ulrik, Charlotte Suppli, Sherson, David Lee, Meyer, Harald William, Ebbehøj, Niels, Sigsgaard, Torben, Zock, Jan Paul, Baur, Xaver, Schlünssen, Vivi, Dalbøge, Annett, Albert Kolstad, Henrik, Ulrik, Charlotte Suppli, Sherson, David Lee, Meyer, Harald William, Ebbehøj, Niels, Sigsgaard, Torben, Zock, Jan Paul, Baur, Xaver, and Schlünssen, Vivi
- Abstract
Objectives: The aim was to identify, appraise, and synthesize the scientific evidence of the relationship between potential occupational sensitizing exposures and the development of asthma based on systematic reviews. Methods: The study was conducted as an overview of systematic reviews. A systematic literature search was conducted for systematic reviews published up to 9 February 2020. Eligibility study criteria included persons in or above the working age, potential occupational sensitizing exposures, and outcomes defined as asthma. Potential occupational sensitizing exposures were divided into 23 main groups comprising both subgroups and specific exposures. Two reviewers independently selected studies, extracted study data, assessed study quality, and evaluated confidence in study results and level of evidence of the relationship between potential occupational sensitizing exposures and asthma. Results: Twenty-seven systematic reviews were included covering 1242 studies and 486 potential occupational sensitizing exposures. Overall confidence in study results was rated high in three systematic reviews, moderate in seven reviews, and low in 17 reviews. Strong evidence for the main group of wood dusts and moderate evidence for main groups of mites and fish was found. For subgroups/specific exposures, strong evidence was found for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals, whereas moderate evidence was found for 52 subgroups/specific exposures. Conclusions: This overview identified hundreds of potential occupational sensitizing exposures suspected to cause asthma and evaluated the level of evidence for each exposure. Strong evidence was found for wood dust in general and for toluene diisocyanates, Aspergillus, Cladosporium, Penicillium, and work tasks involving exposure to laboratory animals.
- Published
- 2023
23. COVID-19: A New Virus as a Potential Rapidly Spreading in the Worldwide
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Fariba Rezaeetalab, Mahnaz Mozdourian, Mahnaz Amini, Zahra Javidarabshahi, and Farzaneh Akbari
- Subjects
covid-19 ,mortality ,respiratory symptom ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Covid-19 is a novel virus with high affinity to spread in the community. In December 2019, it was first identified in Wuhan, China. The symptoms are non-specific, so fever, cough, dyspnea, are prominent features. Respiratory failure and mortality have also been reported. The most common lung CT scan findings are bilateral ground glass opacities.
- Published
- 2020
- Full Text
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24. Is there still a social gradient in respiratory symptoms? A population-based Nordic EpiLung-study.
- Author
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Andersén H, Bhatta L, Bashir M, Nwaru B, Langhammer A, Krokstad S, Piirilä P, Hisinger-Mölkänen H, Backman H, Kankaanranta H, and Hedman L
- Subjects
- Humans, Cross-Sectional Studies, Norway epidemiology, Social Class, Cough epidemiology, Cough etiology, Dyspnea, Respiratory Sounds etiology
- Abstract
Background: Respiratory symptoms are a common public health issue that can partly be attributed to preventable risk factors, such as tobacco smoking and occupational exposure, which are more common in individuals with lower socioeconomic status., Objective: Our aim was to evaluate the social gradient in respiratory symptoms in Nordic countries., Methods: This study included participants aged 30-65 years from five cross-sectional population-based questionnaire surveys in 2016 in Finland and Sweden (N = 25,423) and in 2017-2019 in Norway (N = 27,107). Occupational skill levels 1 and 2 (occupations requiring compulsory education) were combined and compared to skill levels 3 and 4 (occupations requiring upper secondary and tertiary education). Meta-analysis was conducted to obtain pooled age- and sex adjusted odds ratios (aORs) of associations between occupational skill and the respiratory symptoms including recurrent wheeze, dyspnoea, and productive cough., Results: In the meta-analysis, recurrent wheeze, dyspnoea, and productive cough showed a social gradient. The participants with occupational skill 1 and 2 had higher risk for recurrent wheeze (aOR 1.78, 95% CI 1.34-2.22) and dyspnoea (aOR 1.59, 95% CI 1.29-1.90) compared to occupational skill 3 and 4 in Sweden and Finland. Similarly increased risk was observed for combined assessment of dyspnoea and wheeze (aOR 1.05, 95% CI 1.03-1.07) in Norway. In a meta-analysis including all three countries, the aOR for productive cough was 1.31 95% CI 1.07-1.56., Conclusions: Occupations with lower, compared to higher, skill levels were associated with an increased risk of recurrent wheeze, dyspnoea, and productive cough., Competing Interests: Declaration of competing interest AL reports that the HUNT Lung Study in HUNT 2 and 3 was partly funded by non-demanding funds from AstraZeneca. AL has received fee from AstraZeneca, Boehringer-Ingelheim, GSK, and Diagnostica for lectures and participation in advisory boards. HB reports personal fees from Astra Zeneca, personal fees from Boehringer Ingelheim and personal fees from GlaxoSmithKline, outside the submitted work. HHM was previously an employer of Orion Pharma but does not have any conflict of interests related to this epidemiological study. HK reports personal fees from Astra Zeneca, personal fees from Orion Pharma, personal fees from Mundipharma, personal fees from Boehringer Ingelheim, personal fees from Chiesi Pharma AB, personal fees from GlaxoSmithKline, personal fees from MSD, personal fees from Novartis, personal fees from Sanofi Genzyme, outside the submitted work. Other authors have no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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25. Characteristics of asthma and COPD overlap syndrome (ACOS) in the Canadian population.
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Senthilselvan, Ambikaipakan and Beach, Jeremy
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OBSTRUCTIVE lung diseases , *ASTHMA , *RESPIRATORY diseases , *DYSPNEA - Abstract
Objective: Asthma is a chronic disease affecting both children and adults, whereas chronic obstructive pulmonary disease (COPD) is a respiratory disease most commonly related to smoking and is usually seen in adults. When the airway disease shares features of both asthma and COPD, the phenotype is referred to as asthma and COPD overlap syndrome (ACOS). The objective of this cross-sectional study is to characterize ACOS in the Canadian population. Methods: Data from the first three cycles of the Canadian Health Measures Survey (CHMS) were used in this study. The study included 9059 subjects aged 30 years and above. The CHMS included a detailed interviewer-administered questionnaire and spirometry measurements. Based on the self-report, subjects were categorized into control, ACOS, COPD only and asthma only groups. Results: The prevalence of ACOS, COPD and asthma groups was 1.59%, 2.21% and 6.65%, respectively. The proportion of females was significantly greater than males in the ACOS group. The proportion of wheeze was highest in the ACOS group (64.93%) whereas the prevalence of shortness of breath was the highest in the COPD group (46.25%). Heart disease, cancer, arthritis and liver disease were more prevalent in the ACOS group than in COPD, asthma and control groups. Severity of airway obstruction was the highest in the ACOS group and was followed by COPD, asthma and control groups, respectively. Conclusions: Characteristics of ACOS in the Canadian population were similar to those observed in the developed countries and longitudinal studies are required to determine the incidence and risk factors of ACOS. [ABSTRACT FROM AUTHOR]
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- 2019
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26. Association of site of treatment with clinical outcomes following intravenous antimicrobial treatment of a pulmonary exacerbation
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M. Skalland, Christopher H. Goss, Patrick A. Flume, Natalie E. West, Umer Khan, Sonya L. Heltshe, Donald R. VanDevanter, and Don B. Sanders
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Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Randomization ,Cystic Fibrosis ,business.industry ,Antimicrobial ,medicine.disease ,Cystic fibrosis ,Article ,Anti-Bacterial Agents ,Clinical trial ,Respiratory symptom ,Anti-Infective Agents ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Propensity score matching ,Humans ,Medicine ,Administration, Intravenous ,business ,Lung ,Lung function ,Pulmonary exacerbation - Abstract
BACKGROUND: In the STOP2 (Standardized Treatment of Pulmonary Exacerbations-2) study, intravenous (IV) antimicrobial treatment duration for adults with cystic fibrosis (CF) experiencing pulmonary exacerbations (PEx) was determined based on initial treatment response. The impact of home vs hospital care remains an important clinical question in CF. Our hypothesis was that STOP2 participants treated at home would have less improvement in lung function compared to those treated in the hospital. METHODS: Treating clinicians determined PEx treatment location, which was a stratification factor for STOP2 randomization. Lung function, weight, and symptom recovery were evaluated by treatment location. Propensity scores and inverse probability treatment weighting were used to test for differences in clinical response by treatment location. RESULTS: In all, 33% of STOP2 participants received IV antimicrobials in the hospital only, 46% both in the hospital and at home, and 21% at home only. Mean (95% CI) ppFEV(1) improvement was significantly (p
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- 2022
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27. Discussion
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Zahnd, Alexander and Zahnd, Alexander
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- 2013
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28. Application of Operations Research to Funding Decisions for Treatments with Rare Disease
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Coyle, Doug, Bell, Chaim M., Clarke, Joe T. R., Evans, Gerald, Gadhok, Anita, Martin, Janet, Sabharwal, Mona, Winquist, Eric, and Zaric, Gregory S., editor
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- 2013
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29. Case 55
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Joarder, Rita, Crundwell, Neil, Joarder, Rita, and Crundwell, Neil
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- 2012
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30. Effect of onion ( Allium cepa L.) peel extract on natural killer cell and cytokines in a randomized, double-blind, placebo-controlled trial.
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Cho H, Kim S, Lee SH, and Park Y
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Background/objectives: Onion, particularly onion peel, is a quercetin-rich food with, anti-inflammatory and immunomodulatory effects. However, the effect of onion peel extract (OPE) in humans is unclear. Thus, the present study aimed to investigate whether OPE improves natural killer (NK) cell activity and cytokine concentration in a randomized double-blind placebo-controlled trial., Subjects/methods: Eighty participants aged 19-64 yrs old with a white blood cell count of 4,000-10,000 cells/µL, symptoms of upper respiratory infection at least once within the previous 12 mon, and perceived stress scale (PSS) over 14 were included. Participants were randomly assigned to take either 1,000 mg/day OPE or a placebo for 8 weeks., Results: Compliance were 87.4 ± 8.6% and 86.9 ± 79.0% in OPE and placebo groups. Compared to the placebo, OPE supplementation improved "Hoarseness" ( P = 0.038) of the Wisconsin Upper Respiratory Symptom Survey (WURSS)-21 symptom, and stress scores ( P = 0.001; 0.021) of PSS. Supplementation of OPE had no significant effect on NK cell activity and concentrations of cytokines such as interleukin (IL)-2, IL-6, IL-12, IL-1β, interferon-γ, and tumor necrosis factor-α. At baseline, the WURSS-21 symptom and PSS score ( P = 0.024; 0.026) were higher in the OPE group than the placebo group. Among participants with higher than median WURSS-21 symptom score, OPE supplementation increased NK cell activity ( P = 0.038). Supplementation of OPE had no significant effects on safety measurements and adverse events., Conclusions: The present study suggested that OPE supplementation improves NK cell activity in participants with moderate upper respiratory symptoms without any significant adverse effects., Trial Registration: ClinicalTrials.gov Identifier: NCT05666752., Competing Interests: Conflict of Interest: The authors declare no potential conflicts of interests., (©2024 The Korean Nutrition Society and the Korean Society of Community Nutrition.)
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- 2024
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31. Gastroesophageal reflux and snoring are related to asthma and respiratory symptoms: Results from a Nordic longitudinal population survey.
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Mir Fakhraei R, Lindberg E, Benediktsdóttir B, Svanes C, Johannessen A, Holm M, Modig L, Franklin KA, Malinovschi A, Gislason T, Jõgi R, Cramer C, Janson C, and Emilsson ÖI
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- Humans, Snoring complications, Snoring epidemiology, Prospective Studies, Surveys and Questionnaires, Respiratory Sounds etiology, Risk Factors, Gastroesophageal Reflux complications, Gastroesophageal Reflux epidemiology, Gastroesophageal Reflux diagnosis, Asthma complications, Asthma epidemiology, Asthma diagnosis
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Aim: To study if individuals with nocturnal gastroesophageal reflux (nGER) and habitual snoring are more likely to develop asthma and respiratory symptoms (i.e. wheeze, cough, chest tightness, breathlessness) than those without these conditions, and if these associations are additive., Methods: We used data from the population-based prospective questionnaire study Respiratory Health in Northern Europe (RHINE) (11,024 participants), with data from 1999 and 2011. Participants with heartburn or belching after going to bed, at least 1 night/week, were considered to have nGER. Participants reporting loud snoring at least 3 nights/week were considered to have habitual snoring. Participants were grouped into four groups by their nGER and snoring status: "never"; "former"; "incident"; "persistent". Incident respiratory symptoms were analyzed among participants without respective symptom at baseline., Results: Snoring and nGER were independently associated with incident asthma and respiratory symptoms. The risk of incident wheeze was increased in subjects with incident or persistent snoring (adjusted odds ratio (95 % CI): 1.44 (1.21-1.72)), nGER (2.18 (1.60-2.98)) and in those with both snoring and nGER (2.59 (1.83-3.65)). The risk of developing asthma was increased in subjects with incident or persistent snoring (1.44 (1.15-1.82)), nGER (1.99 (1.35-2.93)) and in those with both snoring and nGER (1.72 (1.06-2.77)). No significant interaction was found between snoring and nGER. A similar pattern was found for the incidence of all other respiratory symptoms studied, with the highest risk among those with both incident or persistent nGER and snoring., Conclusion: The risk of developing asthma and respiratory symptoms is increased among subjects with nGER and habitual snoring. These associations are independent of each other and confounding factors. Snoring and nGER together are additive on respiratory symptoms., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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32. Respiratory Symptoms Occurring 4 Months After Allogeneic Hematopoietic Stem Cell Transplantation
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Bergeron, Anne, Feuillet, Séverine, Meignin, Véronique, Ribaud, Patricia, Tazi, Abdellatif, and Azoulay, Elie, editor
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- 2011
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33. Respiratory Symptoms from Fragrances and the Link with Dermatitis
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Elberling, Jesper, Johansen, Jeanne Duus, editor, Frosch, Peter J., editor, and Lepoittevin, Jean-Pierre, editor
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- 2011
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34. Persistent Positive Real-Time Reverse Transcription Polymerase Chain Reaction (RT-PCR) Results in Recovered COVID-19 Hospital Patients: Implications for Interpretation.
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Hur J, Kim DM, Park D, and Chang MC
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Background Real-time reverse transcription polymerase chain reaction (RT-PCR) test results often remain positive in patients with COVID-19, even after their symptoms have improved. We compared the characteristics of patients with persistently positive RT-PCR test results despite improved COVID-19 symptoms to those whose RT-PCR test results turned negative following symptom improvement. Materials and methods A total of 143 adult patients with COVID-19 who were hospitalized at a tertiary university hospital were enrolled. Demographic, clinical, treatment, and epidemiological data were extracted from their electronic medical records. These data were compared between patients with persistently positive RT-PCR test results and those with negative RT-PCR test results after symptom improvement. Results The prevalence of cough and respiratory symptoms was less in COVID-19 patients with persistently positive RT-PCR test results after symptom improvement than in other patients with COVID-19 (p<0.05). Conclusion Persistently positive patients had a lower prevalence of cough than those who became negative. None of the other examined co-variates (hypertension, chronic kidney disease, chronic lung disease, dyslipidemia, etc.) was associated with the persistent positivity., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Hur et al.)
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- 2023
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35. The Relationship Between Potential Occupational Sensitizing Exposures and Asthma: An Overview of Systematic Reviews
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lung disease ,respiratory symptom ,work ,Allergen ,allergy - Published
- 2022
36. Respiratory Health and Cross-Shift Changes of Foundry Workers in Iran.
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Saraei, Mayam, Masoudi, Habibbolah, Aminian, Omid, and Izadi, Nazanin
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THRESHOLD limit values (Industrial toxicology) , *HEALTH promotion , *BODY mass index , *RESPIRATORY organs , *CAST-iron - Abstract
Background: Respirable dust exposure is associated with increased respiratory impairment. As there are various airborne contaminants in the foundry industry, our aim was to thoroughly examine the acute effects of ambient respiratory dust on the respiratory system. Materials and Methods: A cross-shift study was conducted in a cast iron foundry in Iran. A total of 200 participants, including 110 workers from production department and 90 office workers were enrolled in this study. Workers were evaluated with regard to respiratory symptoms using the American Thoracic Society (ATS) questionnaire and examination of their lung function by spirometry. Results: The mean exposure of all studied substances was higher than occupational exposure limits. The most common respiratory symptom in exposed workers was cough (24.5%). A statistically significant post shift reduction in FEV1 and FEF25-75 was seen in exposed group. After adjusting for age, working history, smoking and Body Mass Index (BMI), there was a significant decrease based on exposure in FEV1 and FVC. Conclusion: Dust exposure was a significant predictor of lung function. Implementing the health promotion program, periodic medical surveillance and efficient use of respiratory protection equipment could help to protect foundry workers from respiratory impairment. [ABSTRACT FROM AUTHOR]
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- 2018
37. Sources of household air pollution: The association with lung function and respiratory symptoms in middle-aged adult.
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Devien, Laurent, Giovannelli, Jonathan, Cuny, Damien, Matran, Régis, Amouyel, Philippe, Hulo, Sébastien, Edmé, Jean Louis, and Dauchet, Luc
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- *
AIR pollution , *HEALTH , *LUNG physiology , *RESPIRATORY diseases , *HEALTH of middle-aged persons , *SPIROMETRY , *ENVIRONMENTAL health - Abstract
Introduction The objective of the present study was to investigate the relationship between sources of household air pollution, respiratory symptoms and lung function. Methods 3039 adults aged from 40 to 65 participated in the 2011–2013 ELISABET cross-sectional survey in northern France. Lung function was measured using spirometry. During a structured interview, respiratory symptoms, household fuels, exposure to moulds, and use of ventilation were recorded on a questionnaire. Results The self-reported presence of mould in at least two rooms (not including the bathroom and the kitchen) was associated with a 2.5% lower predicted forced expiratory volume in 1 s (95% confidence interval, −4.7 to −0.29; p-trend <0.05) and a higher risk of wheezing (p-trend < 0.001). Visible condensation was associated with wheezing (p < .05) and chronic cough (p < .05). There were no significant associations with the type of household fuel or inadequate ventilation/aeration. Similar results were found when the analyses were restricted to participants without known respiratory disease. Conclusion Our results suggest that the presence of mould (known to be associated with more severe asthma symptoms) could also have an impact on respiratory symptoms and lung function in the general population and in populations without known respiratory disease. [ABSTRACT FROM AUTHOR]
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- 2018
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38. Possible Impacts of Nanoparticles on Children of Thai Construction Industry
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Musikaphan, W., Kitisriworaphan, T., Bittnar, Zdeněk, editor, Bartos, Peter J. M., editor, Němeček, Jiří, editor, Šmilauer, Vít, editor, and Zeman, Jan, editor
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- 2009
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39. Hospital-acquired influenza in the United States, FluSurv-NET, 2011–2012 through 2018–2019
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Sue Kim, Tali Azenkot, William Schaffner, Chelsea McMullen, Arthur Reingold, Melissa McMahon, Alissa O’Halloran, Laurie M Billing, Ann Thomas, Shikha Garg, Patricia Ryan, Nisha B Alden, Carrie Reed, H. Keipp Talbot, James I. Meek, Nancy M. Bennett, Nancy L Spina, Evan J. Anderson, Andrea George, and Charisse N Cummings
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Adult ,Microbiology (medical) ,medicine.medical_specialty ,Epidemiology ,Influenza vaccine ,medicine.medical_treatment ,Population ,Internal medicine ,Influenza, Human ,medicine ,Humans ,Infection control ,Positive test ,Child ,education ,Aged ,Mechanical ventilation ,education.field_of_study ,business.industry ,Vaccination ,Hospitals ,United States ,Hospitalization ,Respiratory symptom ,Cross-Sectional Studies ,Infectious Diseases ,Influenza Vaccines ,Seasons ,business ,Onset date - Abstract
Objective:To estimate population-based rates and to describe clinical characteristics of hospital-acquired (HA) influenza.Design:Cross-sectional study.Setting:US Influenza Hospitalization Surveillance Network (FluSurv-NET) during 2011–2012 through 2018–2019 seasons.Methods:Patients were identified through provider-initiated or facility-based testing. HA influenza was defined as a positive influenza test date and respiratory symptom onset >3 days after admission. Patients with positive test date >3 days after admission but missing respiratory symptom onset date were classified as possible HA influenza.Results:Among 94,158 influenza-associated hospitalizations, 353 (0.4%) had HA influenza. The overall adjusted rate of HA influenza was 0.4 per 100,000 persons. Among HA influenza cases, 50.7% were 65 years of age or older, and 52.0% of children and 95.7% of adults had underlying conditions; 44.9% overall had received influenza vaccine prior to hospitalization. Overall, 34.5% of HA cases received ICU care during hospitalization, 19.8% required mechanical ventilation, and 6.7% died. After including possible HA cases, prevalence among all influenza-associated hospitalizations increased to 1.3% and the adjusted rate increased to 1.5 per 100,000 persons.Conclusions:Over 8 seasons, rates of HA influenza were low but were likely underestimated because testing was not systematic. A high proportion of patients with HA influenza were unvaccinated and had severe outcomes. Annual influenza vaccination and implementation of robust hospital infection control measures may help to prevent HA influenza and its impacts on patient outcomes and the healthcare system.
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- 2021
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40. Respiratory Symptoms Are Associated With Frailty in Older Adults With Normal Spirometry, Independent of Smoking, in the Canadian Longitudinal Study of Aging
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Caitlyn Bourque, Robert E. Dales, Jinhui Ma, Lauren Griffith, Oxana Mian, MyLinh Duong, and Chris P. Verschoor
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Pulmonary and Respiratory Medicine ,Spirometry ,Aging ,Canada ,Longitudinal study ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,FEV1/FVC ratio ,Interquartile range ,Forced Expiratory Volume ,Internal medicine ,Humans ,Medicine ,Longitudinal Studies ,Respiratory system ,Lung ,Original Research ,Aged ,Aged, 80 and over ,Normal spirometry ,Frailty ,medicine.diagnostic_test ,business.industry ,Smoking ,General Medicine ,Middle Aged ,Respiratory symptom ,Cross-Sectional Studies ,medicine.anatomical_structure ,business - Abstract
BACKGROUND: Recent studies have demonstrated that even in the absence of lung impairment as determined by spirometry, smoking and respiratory symptoms are associated with poor overall health and well-being. However, this relationship is not well defined; and it remains unclear the degree to which symptoms are related to poor health, independent of smoking. This is of particular importance to older adults, as they are more likely to exhibit respiratory symptoms and are, therefore, at risk of not receiving appropriate treatment if they have never smoked and have normal spirometry. METHODS: We performed a cross-sectional analysis of data from the Canadian Longitudinal Study on Aging to delineate the associations of respiratory symptoms and smoking on the health of participants age 45–86 who exhibited normal spirometry. Participant health was estimated using a frailty index, a multidimensional measure of vulnerability to adverse outcomes that has been validated in numerous health settings. RESULTS: Of the 21,293 participants included in our analysis, 87% exhibited a normal FEV1, FVC, and FEV1/FVC; of those, 45% reported at least one respiratory symptom, and 50% were former or current smokers. Both respiratory symptoms and smoking were independently associated with frailty (median interquartile range [IQR] = 0.11 [0.07–0.15]), the most substantial associations observed for those having at least one respiratory symptom (adjusted β 0.023, 95% CI 0.022–0.025) and current smokers with > 10 pack-year exposure (adjusted β 0.014, 95% CI [0.010–0.019). Not only was the association between symptoms and frailty evident in never smokers, a significant proportion of the total effect of smoking on frailty was observed to be mediated by symptoms. CONCLUSIONS: Our data show that respiratory symptoms, regardless of smoking history, were a significant correlate of frailty in older adults with normal spirometry. Hence, they should not be simply regarded as a benign by-product of aging.
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- 2021
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41. Postdischarge Recovery after Acute Pediatric Lung Disease Can Be Quantified with Digital Biomarkers
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Adam F. Cohen, Gertjan J. Driessen, Matthijs D. Kruizinga, Frederik E. Stuurman, Ahnjili Zhuparris, Marianne Nuijsink, Allison Moll, Dimitrios Ziagkos, RS: GROW - R4 - Reproductive and Perinatal Medicine, and Kindergeneeskunde
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Pulmonary and Respiratory Medicine ,PNEUMONIA ,medicine.medical_specialty ,Linear mixed model ,PRESCHOOL-CHILDREN ,Wearable ,QUESTIONNAIRE ,Aftercare ,At-home recovery ,Pediatrics ,THERAPY ,VALIDATION ,Interquartile range ,Internal medicine ,Heart rate ,medicine ,Hospital discharge ,Humans ,Child ,Asthma ,Respiratory Sounds ,Acute lung disease ,Wheezing ,business.industry ,medicine.disease ,Patient Discharge ,Clinical trial ,Pneumonia ,Respiratory symptom ,Lung disease ,Basic Science Investigations ,Child, Preschool ,Acute Disease ,business ,Biomarkers - Abstract
Background: Pediatric patients admitted for acute lung disease are treated and monitored in the hospital, after which full recovery is achieved at home. Many studies report in-hospital recovery, but little is known regarding the time to full recovery after hospital discharge. Technological innovations have led to increased interest in home-monitoring and digital biomarkers. The aim of this study was to describe at-home recovery of 3 common pediatric respiratory diseases using a questionnaire and wearable device. Methods: In this study, patients admitted due to pneumonia (n = 30), preschool wheezing (n = 30), and asthma exacerbation (AE; n = 11) were included. Patients were monitored with a smartwatch and a questionnaire during admission, with a 14-day recovery period and a 10-day “healthy” period. Median compliance was calculated, and a mixed-effects model was fitted for physical activity and heart rate (HR) to describe the recovery period, and the physical activity recovery trajectory was correlated to respiratory symptom scores. Results: Median compliance was 47% (interquartile range [IQR] 33–81%) during the entire study period, 68% (IQR 54–91%) during the recovery period, and 28% (IQR 0–74%) during the healthy period. Patients with pneumonia reached normal physical activity 12 days postdischarge, while subjects with wheezing and AE reached this level after 5 and 6 days, respectively. Estimated mean physical activity was closely correlated with the estimated mean symptom score. HR measured by the smartwatch showed a similar recovery trajectory for subjects with wheezing and asthma, but not for subjects with pneumonia. Conclusions: The digital biomarkers, physical activity, and HR obtained via smartwatch show promise for quantifying postdischarge recovery in a noninvasive manner, which can be useful in pediatric clinical trials and clinical care.
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- 2021
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42. Gastroesophageal Reflux Disease, Cough, and Asthma
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Shah, Niral, Mintz, Matthew L., Skolnik, Neil S., editor, and Mintz, Matthew L., editor
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- 2006
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43. Obesity
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Chatterjee, Rebecca, Mintz, Matthew L., Skolnik, Neil S., editor, and Mintz, Matthew L., editor
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- 2006
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44. Respiratory Symptoms in Atopic Eczema — Focus on Asthma and Early Treatment
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Haahtela, T., Ring, Johannes, editor, Przybilla, Bernhard, editor, and Ruzicka, Thomas, editor
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- 2006
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45. Use of a new ALS specific respiratory questionnaire: the ARES score
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Edward J. Kasarskis, Terry Heiman-Patterson, Asha George, Daohai Yu, Carlayne E. Jackson, and Michael Sherman
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medicine.medical_specialty ,Scale (ratio) ,business.industry ,Amyotrophic Lateral Sclerosis ,Vital Capacity ,medicine.disease ,humanities ,respiratory tract diseases ,Respiratory symptom ,Neurology ,Spirometry ,Surveys and Questionnaires ,Breathing ,Physical therapy ,medicine ,Humans ,Neurology (clinical) ,Respiratory system ,Amyotrophic lateral sclerosis ,business - Abstract
Objective: To develop an ALS respiratory symptom scale (ARES) and evaluate how ARES compares to Medical Research Council Modified Dyspnea Scale (MRC), Borg dyspnea scale, and respiratory subscores ...
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- 2021
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46. The Gastroesophageal Reflux in Patients with Respiratory Symptoms
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Ottolenghi, Alberto, Camoglio, Francesco S., Valletta, Enrico, Pasquini, Anna, Giacomello, Luca, Esposito, Ciro, editor, Montupet, Philippe, editor, and Rothenberg, Steven, editor
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- 2004
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47. Increased Chromosomal Damage among Children in Proximity to an Industrial Zone
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Sopian, Nor Ashikin, Jalaludin, Juliana, Mayusi, Tengku Zatil Aleyya Tengku, and Latif, Mohd Talib
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- 2020
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48. Heterogeneity of post-COVID impairment: interim analysis of a prospective study from Czechia
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Vladimir Koblizek, Michal Svoboda, Michal Homolac, Miroslav Fajfr, Martin Hyrsl, Mikuláš Skála, Eva Kocova, Viktor Chrobok, Stanislav Plíšek, Radek Sleha, Petr Prášil, Pavel Bostik, and Michal Kopecky
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Computer tomography ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Symptom ,Short Report ,Infectious and parasitic diseases ,RC109-216 ,Biology ,03 medical and health sciences ,Post-Acute COVID-19 Syndrome ,0302 clinical medicine ,Virology ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Respiratory system ,Prospective cohort study ,Lung ,Lung function ,Czech Republic ,SARS-CoV-2 ,COVID-19 ,Interim analysis ,Hospitalization ,Respiratory symptom ,Infectious Diseases ,030228 respiratory system ,Post-COVID ,6-min Walk Test - Abstract
We stratified post-COVID patients into four newly established clinical groups based on the presence or absence of at least one subjective respiratory symptom and at least one objective sign of pulmonary involvement. Nearly half of outpatients and one third of hospitalized post-COVID patients had objective signs of pulmonary involvement without accompanying subjective respiratory symptoms three months after diagnosis.
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- 2021
49. Dust exposure and lung function of workers in the brick and clay pottery factories in the Northeast of Thailand.
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Laohasiriwong, Wongsa, Srathonghon, Wannanapa, Phajan, Teerasak, Assana, Supat, and Intamat, Somsak
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- *
PHYSIOLOGICAL effects of dust , *PULMONARY function tests , *POTTERY industry , *BRICK industry , *PARTICULATE matter , *DYSPNEA , *SPIROMETRY , *PUBLIC health - Abstract
This study aimed to determine the particulate matter concentrations (PM10) in workplace air and personal dust, and their effects on the respiratory health of exposed workers. The lung function of 449 exposed workers was examined. The concentration of PM10 in workplace air and personal dust exposure was measured. Spirometry was used to evaluate the lung function capacity included forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory volume ratio (FEV%) and peak expiratory flow rate (PEF). The forced expiratory flow at 25% to 75% of the FVC (FEF 25-75%) was determined. The PM10 concentration in workplace air (6 study sites) and personal dust (4 study sites) exceeded the standard (REL) of 0.12 mg/m3. The results of this study showed a decrease in the mean values and percent predicted value of FVC, FEV1, FEV1%, PEF and FEF 25-75%. The lung capacity of participants revealed that 24.50%, 4.45% and 7.13% had mildly, moderately restrictive and small airway disease. The respiratory symptoms were dyspnoea (22.49%), wheezing (10.69%), chest pain (10.69%) and chronic cough (2.90%). Factors influencing lung capacity included mask usage (Adj.OR: 0.44 CI: 0.25-0.79 p-value: 0.006) and chest pain (Adj.OR: 2.68 CI: 1.14-6.30 p-value: 0.024). [ABSTRACT FROM PUBLISHER]
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- 2017
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50. Effects of exposure to flour dust on respiratory symptoms and pulmonary function of mill workers
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Hamdy A. Mohammadien, Mona T. Hussein, and Raafat T. El-Sokkary
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Flour mill workers ,Flour dust ,Respiratory symptom ,Pulmonary function test ,Diseases of the respiratory system ,RC705-779 - Abstract
Objective: To assess the effect of exposure to flour dust on respiratory symptoms and lung function of flour mill workers and to estimate the additive effect of smoking on pulmonary function. Patients and methods: This study was carried out at flour mills in Sohag Governorate. Two hundred male workers with current exposure to flour dust and two hundred non-exposed male as a control group were interviewed and self designed study questionnaire was administered to them and the parameters of their pulmonary function were measured. Results: Respiratory symptoms such as cough, expectoration, wheezing, and shortness of breath, were significantly (p
- Published
- 2013
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