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17 results on '"Rethineswaran, Vinoth Kumar"'

2. Author Correction: Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Author

Park, Ji Hye, Kim, Hyeok, Moon, Hyung Ryong, Park, Bong-Woo, Park, Jae-Hyun, Sim, Woo-Sup, Kim, Jin-Ju, Lim, Hye Ji, Kim, Yeon-Ju, Ji, Seung Taek, Jang, Woong Bi, Rethineswaran, Vinoth Kumar, Van, Le Thi Hong, Giang, Ly Thanh Truong, Yun, Jisoo, Ha, Jong Seong, Ban, Kiwon, Chung, Hae Young, Baek, Sang Hong, Park, Hun-Jun, and Kwon, Sang-Mo

Published
2022
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3. Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Author

Park, Ji Hye, Kim, Hyeok, Moon, Hyung Ryong, Park, Bong-Woo, Park, Jae-Hyun, Sim, Woo-Sup, Kim, Jin-Ju, Lim, Hye Ji, Kim, Yeon-Ju, Ji, Seung Taek, Jang, Woong Bi, Rethineswaran, Vinoth Kumar, Van, Le Thi Hong, Giang, Ly Thanh Truong, Yun, Jisoo, Ha, Jong Seong, Ban, Kiwon, Chung, Hae Young, Baek, Sang Hong, Park, Hun-Jun, and Kwon, Sang-Mo

Published
2021
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5. StemRegenin-1 Attenuates Endothelial Progenitor Cell Senescence by Regulating the AhR Pathway-Mediated CYP1A1 and ROS Generation

Author

Lim, Hye Ji, primary, Jang, Woong Bi, additional, Rethineswaran, Vinoth Kumar, additional, Choi, Jaewoo, additional, Lee, Eun Ji, additional, Park, Sangmi, additional, Jeong, Yeoreum, additional, Ha, Jong Seong, additional, Yun, Jisoo, additional, Choi, Young Jin, additional, Hong, Young Joon, additional, and Kwon, Sang-Mo, additional

Published
2023
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8. Engineered M13 Peptide Carrier Promotes Angiogenic Potential of Patient-Derived Human Cardiac Progenitor Cells and In VivoEngraftment

Author

Jang, Woong Bi, Ji, Seung Taek, Park, Ji Hye, Kim, Yeon-Ju, Kang, Songhwa, Kim, Da Yeon, Lee, Na-Kyung, Kim, Jin Su, Lim, Hye Ji, Choi, Jaewoo, Le, Thi Hong Van, Ly, Thanh Truong Giang, Rethineswaran, Vinoth Kumar, Kim, Dong Hwan, Ha, Jong Seong, Yun, Jisoo, Baek, Sang Hong, and Kwon, Sang-Mo

Abstract

Background:: Despite promising advances in stem cell-based therapy, the treatment of ischemic cardiovascular diseases remains a big challenge due to both the insufficient in vivoviability of transplanted cells and poor angiogenic potential of stem cells. The goal of this study was to develop therapeutic human cardiac progenitor cells (hCPCs) for ischemic cardiovascular diseases with a novel M13 peptide carrier. Method:: In this study, an engineered M13 peptide carrier was successfully generated using a QuikChange Kit. The cellular function of M13 peptide carrier-treated hCPCs was assessed using a tube formation assay and scratch wound healing assay. The in vivoengraftment and cell survival bioactivities of transplanted cells were demonstrated by immunohistochemistry after hCPC transplantation into a myocardial infarction animal model. Results:: The engineered M13RGD+SDKPpeptide carrier, which expressed RGD peptide on PIII site and SDKP peptide on PVIII site, did not affect morphologic change and proliferation ability in hCPCs. In contrast, hCPCs treated with M13RGD+SDKPshowed enhanced angiogenic capacity, including tube formation and migration capacity. Moreover, transplanted hCPCs with M13RGD+SDKPwere engrafted into the ischemic region and promoted in vivocell survival. Conclusion:: Our present data provides a promising protocol for CPC-based cell therapy via short-term cell priming of hCPCs with engineered M13RGD+SDKPbefore cell transplantation for treatment of cardiovascular disease.

Published
2024
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9. Correction: Rethineswaran et al. CHIR99021 Augmented the Function of Late Endothelial Progenitor Cells by Preventing Replicative Senescence. Int. J. Mol. Sci. 2021, 22, 4796

Author

Rethineswaran, Vinoth Kumar, primary, Kim, Da Yeon, additional, Kim, Yeon-Ju, additional, Jang, WoongBi, additional, Ji, Seung Taek, additional, Van, Le Thi Hong, additional, Giang, Ly Thanh Truong, additional, Ha, Jong Seong, additional, Yun, Jisoo, additional, Jung, Jinsup, additional, and Kwon, Sang-Mo, additional

Published
2022
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11. Inhibitory Effect of Etravirine, a Non-Nucleoside Reverse Transcriptase Inhibitor, via Anterior Gradient Protein 2 Homolog Degradation against Ovarian Cancer Metastasis

Author

Ly, Thanh Truong Giang, primary, Yun, Jisoo, additional, Ha, Jong-Seong, additional, Kim, Yeon-Ju, additional, Jang, Woong-Bi, additional, Van Le, Thi Hong, additional, Rethineswaran, Vinoth Kumar, additional, Choi, Jaewoo, additional, Kim, Jae-Ho, additional, Min, Sang-Hyun, additional, Lee, Dong-Hyung, additional, Yang, Ju-Seok, additional, Chung, Joo-Seop, additional, and Kwon, Sang-Mo, additional

Published
2022
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12. Dronedarone hydrochloride enhances the bioactivity of endothelial progenitor cells via regulation of the AKT signaling pathway

Author

Zhang, Jian, primary, Le, Thi Hong Van, additional, Rethineswaran, Vinoth Kumar, additional, Kim, Yeon-Ju, additional, Jang, Woong Bi, additional, Ji, Seung Taek, additional, Ly, Thanh Truong Giang, additional, Ha, Jong Seong, additional, Yun, Jisoo, additional, Cheong, Jae Hun, additional, Jung, Jinsup, additional, and Kwon, Sang-Mo, additional

Published
2021
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15. Dronedarone hydrochloride enhances the bioactivity of endothelial progenitor cells via regulation of the AKT signaling pathway.

Author

Jian Zhang, Thi Hong Van Le, Rethineswaran, Vinoth Kumar, Yeon-Ju Kim, Woong Bi Jang, Seung Taek Ji, Thanh Truong Giang Ly, Jong Seong Ha, Jisoo Yun, Jae Hun Cheong, Jinsup Jung, and Sang-Mo Kwon

Subjects
PROGENITOR cells, CELLULAR control mechanisms, STEM cell treatment, ENDOTHELIAL cells, TREATMENT effectiveness
Abstract

Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Enzyme-Aided Extraction of Fucoidan by AMG Augments the Functionality of EPCs through Regulation of the AKT/Rheb Signaling Pathway

Author

Rethineswaran, Vinoth Kumar, primary, Kim, Yeon-Ju, additional, Jang, Woong Bi, additional, Ji, Seung Taek, additional, Kang, Songhwa, additional, Kim, Da Yeon, additional, Park, Ji Hye, additional, Van, Le Thi Hong, additional, Giang, Ly Thanh Truong, additional, Ha, Jong Seong, additional, Yun, Jisoo, additional, Lee, Dong Hyung, additional, Yu, Sun-Nyoung, additional, Park, Sul-Gi, additional, Ahn, Soon-Cheol, additional, and Kwon, Sang-Mo, additional

Published
2019
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17. The Roots of Atractylodes macrocephala Koidzumi Enhanced Glucose and Lipid Metabolism in C2C12 Myotubes via Mitochondrial Regulation

Author

Rethineswaran Vinoth Kumar, Tae Woo Oh, Yong-Ki Park, Hyo Won Jung, Seok Yong Kang, and Mi Young Song

Subjects
medicine.medical_specialty, Article Subject, biology, Glucose uptake, AMPK, Lipid metabolism, lcsh:Other systems of medicine, TFAM, medicine.disease, lcsh:RZ201-999, Endocrinology, Insulin resistance, Complementary and alternative medicine, Internal medicine, Sirtuin, biology.protein, medicine, Carnitine, Protein kinase A, Research Article, medicine.drug
Abstract

The root ofAtractylodes macrocephalaKoidzumi (Atractylodis Rhizoma Alba, ARA) is a Traditional Korean Medicine and has been commonly used for weight control. Mitochondrial dysfunction appears to be a key contributor to insulin resistance, and therefore mitochondrial targeting drugs represent an important potential strategy for the treatment of insulin resistance and obesity. In this study, the authors investigated the regulatory effects of ARA on mitochondrial function with respect to the stimulation of glucose and lipid metabolism in C2C12 myotubes. After differentiating C2C12 myotubes, cells were treated with or without different concentrations (0.2, 0.5, and 1.0 mg/mL) of ARA extract. ARA extract significantly increased the expression of peroxisome proliferator-activated receptor coactivator 1 alpha (PGC1α) and the downregulations of its targets, nuclear respiratory factor-1 (NRF-1), transcription factor A (TFAM), and total ATP content in C2C12 myotubes. ARA extract also increased the expressions of PGC1αactivator and of the metabolic sensors, AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase and sirtuin (SIRT) 1. Furthermore, it significantly increased glucose uptake by enhancing glucose consumption and subsequently decreased FFA contents and increased carnitine palmitoyltransferase (CPT) 1b expression. Our study indicates that ARA has a potential for stimulating mitochondrial function and energy metabolism in muscle.

Published
2015

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